ライフサイエンスコーパス: irreversibly

1 fate of the pore, which may reseal or dilate irreversibly.

2 atly perturb the formation of amyloid fibres irreversibly.

3 al, to be visualized immediately and ablated irreversibly.

4 osed repeatedly before dilating or resealing irreversibly.

5 nd consumes neither the walker nor the track irreversibly.

6 an indeed bind to MntC reversibly as well as irreversibly.

7 and converts to the cyclic zwitterionic form irreversibly.

8 atural environment could damage an ecosystem irreversibly.

9 ous alterations, including epigenetic drift, irreversibly accumulate in a stepwise, ratchet-like mann

10 organisms results in homologous chromosomes irreversibly accumulating mutations and thus evolving in

11 icities of yeast and human proteasomes using irreversibly acting alpha',beta'epoxyketone (ep) inhibit

12 tact tumor epithelial cells (TEC) can become irreversibly activated as cancer-associated-fibroblasts

13 G-protein-coupled receptors (GPCRs) that are irreversibly activated by proteolytic cleavage of the N

14 uld serve as a "plate-adherent" substrate to irreversibly adhere the capture antigen/antibody of inte

15 and determine whether the cell reversibly or irreversibly adhered to the surface.

16 of actuation pulses of about 4 V, otherwise irreversibly adsorbed analytes are stripped off, which e

17 cid sites have a high tendency to convert to irreversibly adsorbed carbonaceous deposits and are resp

18 eter thicknesses that were relatively rigid, irreversibly adsorbed, and collapsed upon air drying, as

19 , hence they are usually thought of as being irreversibly adsorbed.

20 muscle homeostatic conditions, and that this irreversibly affects their intrinsic regenerative and se

21 for young girls reaching puberty, because it irreversibly affects their physical and cognitive develo

22 ncy steadily diminished until rhythm stopped irreversibly after 85+/-20 (mean +/- SEM) cellular ablat

23 These drugs irreversibly alkylate parasite DNA, blocking their abili

24 The state of a given scratchpad can be irreversibly altered by CRISPR/Cas9-based targeted mutag

25 modifies beta2M286C side-chain sulfhydryls, irreversibly altering GABA-induced currents.

26 c film on a triolein/water interface and was irreversibly anchored to the lipid surface, which is con

27 eals how only orbiting mode cells can attach irreversibly and form microcolonies.

28 olecular hydrogen in a helium carrier gas by irreversibly and quantitatively scavenging all reactive

29 Replication forks can stall irreversibly, and if two converging forks stall with no

30 ein which can be converted from green to red irreversibly, and thus allows spatiotemporal labeling of

31 spheric oxygen may have varied before rising irreversibly approximately 2.4 billion years ago, during

32 Centrosome loss irreversibly arrested normal cells in a senescence-like

33 Sod2 loss induced cellular senescence, which irreversibly arrested proliferation in a fraction of ker

34 Cellular senescence is a state of irreversibly arrested proliferation, often induced by ge

35 y cilia formation and cellular senescence by irreversibly arresting cell growth.

36 Cellular senescence irreversibly arrests proliferation in response to potent

37 production of female offspring, leaving them irreversibly asexual, further linking host and symbiont.

38 We hypothesized Wolbachia strains infecting irreversibly asexual, resistant to horizontal transfer T

39 ing of up to approximately eight loosely but irreversibly assembled monomeric subunits.

40 required by Pseudomonas fluorescens Pf0-1 to irreversibly attach to a surface and form a biofilm.

41 asma membrane with a polybasic domain and an irreversibly attached lipid instead of palmitate rendere

42 re terbium-labeled fluorescent reporters are irreversibly attached to receptors by metabolic glycan e

43 Second, GUVs shrink irreversibly because the membrane/glass adhesion creatin

44 um-mediated structural plasticity, switching irreversibly between an amorphous aggregate state and th

45 ostics, or therapeutics that selectively and irreversibly bind a target protein in vitro or in living

46 cking oligonucleotides to preferentially and irreversibly bind DNA probes that are mechanically strai

47 In principle, fragments that can irreversibly bind their target can overcome the low affi

48 een shown to disable ibrutinib's capacity to irreversibly bind this primary target, the detailed mech

49 port the development of small molecules that irreversibly bind to a common oncogenic mutant, K-Ras(G1

50 the use of a set of research tools that can irreversibly bind to and affect the function of recombin

51 ive inhibitors of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of this

52 applications as activity-based probes and as irreversibly binding drugs.

53 robe to a warhead capable of selectively and irreversibly binding to the free active form of KDM1A.

54 roxysuccinimidyl (NHS) ester of oleate (SSO) irreversibly binds CD36 and has been widely used to inhi

55 is based on a phosphoramidate scaffold that irreversibly binds to PSMA.

56 lamp experiments, phosphine-stabilized AuNPs irreversibly blocked hERG channels, whereas thiol-stabil

57 rine-containing photoaffinity probe (RX-055) irreversibly blocked membrane transport of both endocann

58 d gastrosophageal reflux disease and acts by irreversibly blocking ATP4A, a P-type H+/K+ ATPase in ga

59 n of lysosomes, and it induces apoptosis and irreversibly blocks proliferation of human lung cancer H

60 esign of more potent compounds, one of which irreversibly blocks ribosomal elongation, preserves poly

61 clickable" benzamide probe was designed that irreversibly bound a single 50 kDa cellular protein, ide

62 The composition of the irreversibly bound lignin component differed markedly be

63 ghest sorption capacity (289.7 mg g(-1)) and irreversibly bound NH(3)(g) (81%) but similar sorption a

64 at suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin remain

65 that DNAN biotransformation products can be irreversibly bound to humin in soils as a remediation st

66 ally trapped by colloidal particles that are irreversibly bound to the oil-water interface.

67 rticle, they are predicted to be essentially irreversibly bound to the viral DNA.

68 In the above examples the dye is reduced irreversibly, but when the photocatalyst in an ink is us

69 le to cause swimming worms to stick together irreversibly by their tails, leading to the rapid format

70 P-Xyl from UDP-glucuronic acid (UDP-GlcA) is irreversibly catalyzed by UDP-glucuronic acid decarboxyl

71 Because proteases irreversibly cleave peptide bonds of protein substrates,

72 We show that this engineered chimeric toxin irreversibly cleaves and inactivates intracellular RAS a

73 When a toluene droplet irreversibly collides with an ultramicroelectrode biased

74 Nonetheless, progenitor cells can irreversibly commit to an erythroid fate well before EPO

75 n and how human embryonic stem cells (hESCs) irreversibly commit to differentiation is a fundamental

76 ising degradation because substrates must be irreversibly committed to degradation before Rpn11 acts.

77 pombe exit the mitotic cell cycle and become irreversibly committed to the completion of meiosis prog

78 It has been hypothesized that, before irreversibly committing, ESCs pass through at least one

79 Gboxin rapidly and irreversibly compromises oxygen consumption in glioblast

80 llowed by pericyte death in rigor, which may irreversibly constrict capillaries and damage the blood-

81 to stimuli and developing probes that do not irreversibly consume H2S.

82 iation capacity steadily decreases, Li(+) is irreversibly consumed at a steady rate, and pronounced S

83 ion and contraction; the rate of Li(+) being irreversibly consumed declines, and the Si SEI thickness

84 Choline can be irreversibly converted to betaine, a major source of met

85 a result, the nanoparticles are rapidly and irreversibly converted to macroscopic aggregates.

86 clic hemiaminal cross-links (7-10) that were irreversibly converted under conditions of reductive ami

87 a-semialdehyde dehydrogenase (GSALDH), which irreversibly converts glutamate gamma-semialdehyde (GSAL

88 tate oxidase (LOX) and catalase (CAT), which irreversibly converts lactate and oxygen to pyruvate and

89 infection, the virus usually wins the race, irreversibly crippling the immune system before an effec

90 yme essential for inhibiting fibrinolysis by irreversibly crosslinking fibrin and antifibrinolytic pr

91 Since incomplete remyelination will irreversibly damage axonal connections, treatments effec

92 strate that pollen proteases selectively and irreversibly damage integrity and anchorage of columnar

93 uring enzymatic catalysis, could rapidly and irreversibly damage polypeptides were protective mechani

94 Formaldehyde is one such compound that can irreversibly damage proteins and DNA through alkylation

95 Distinguishing between irreversibly damaged and surviving tissue could have con

96 the cognitive ability of offspring might be irreversibly damaged as a result of their mother's mild

97 Pancreatic beta-cells become irreversibly damaged by long-term exposure to excessive

98 It has been proposed that when HCs are irreversibly damaged by noise or ototoxic drugs, surroun

99 SirT3 acts to sort moderately stressed from irreversibly damaged organelles.

100 proposed threshold of 1400 ms, the volume of irreversibly damaged tissue was in good agreement with t

101 reduce dinitrogen (N2) to ammonia (NH3), is irreversibly damaged upon exposure to molecular oxygen (

102 is and causes degenerative muscle disease by irreversibly dampening satellite cell (SC) self-renewal

103 o-11,12-didehydrodibenzo[a,e][8]annulene and irreversibly deactivate the diamagnetic molybdenum metal

104 unmet medical needs for life threatening or irreversibly debilitating conditions.

105 r Unmet Medical Need for Life Threatening or Irreversibly Debilitating Diseases or Conditions documen

106 nt condensin from misfolding the RDN into an irreversibly decondensed state.

107 Here we establish a platform for irreversibly decorating VLPs simply by mixing with prote

108 d in various physiological processes, can be irreversibly degraded by the membrane-bound S1P lyase (S

109 and, it is found that overstressed LEDs show irreversibly degraded device performance, possibly becau

110 Sphingosine-1-phosphate (S1P) lyase (SPL) irreversibly degrades the bioactive sphingolipid S1P and

111 In contrast, surface water of gammaS-G18V irreversibly dehydrates with moderate concentration incr

112 ived enzyme, without its prosegment (PS), is irreversibly denatured and folds to a thermodynamically

113 of NAPRT amplification and be completely and irreversibly dependent on NAPRT for survival.

114 als whose properties change continuously and irreversibly depending on the experienced time-temperatu

115 back in the CCR5-bound conformation and may irreversibly destabilize gp41 to initiate fusion.

116 n, degradation of host tissue, and bone that irreversibly destroys the supporting apparatus of teeth.

117 the identity of differentiated cells is not irreversibly determined but can be changed back to a plu

118 Exhaustion was not irreversibly determined by initial activation, but was m

119 icating that the autopod positional value is irreversibly determined.

120 post-mitotic cells are generally considered irreversibly developmentally locked, i.e. incapable of b

121 s, including those able to terminally (i.e., irreversibly) differentiate in form and function.

122 d through a transient ('kiss and run') or an irreversibly dilating pore (full fusion).

123 and alkyne substituents, these radicals can irreversibly dimerize, exist as monomers in solution but

124 Protein kinase C (PKC) activation irreversibly diminished Ih and HCN1 surface expression,

125 tems might suffer sharp population drops and irreversibly disintegrate into a system collapse, via a

126 ry cytokines associated with HIV-1 infection irreversibly disrupt ILCs.

127 d of chromatin-remodeling agents and without irreversibly disrupting the host nucleosome.

128 Gestational exposure to SS irreversibly disrupts lung development leading to a BPD-

129 x straightening is reversible, but phosphate irreversibly dissociates from the postpower stroke state

130 d values and the fraction of DNA duplex that irreversibly dissociates in the gas phase.

131 ed with indocyanine green, which rapidly and irreversibly dissociates to fluoresce in the acidic extr

132 Moreover, a significant proportion of the irreversibly downregulated genes featured upstream bindi

133 n be specifically targeted by antibodies and irreversibly downregulated in circulating platelets in v

134 In contrast, KAR activity was irreversibly downregulated in response to induction of l

135 se studies demonstrate that Hsp90 inhibition irreversibly downregulates cell surface expression of cr

136 , while the equilibria can be reversibly and irreversibly driven toward the MOLP products by addition

137 ind that circulating ILCs are lost early and irreversibly during HIV infection.

138 ith Tat protein for 10 to 30 min suffices to irreversibly engage the activation of the TLR4 pathway,

139 which persisted after pathogen clearance and irreversibly escalated in severity with repeated infecti

140 C pecan shell biochars occurred rapidly and irreversibly even at neutral pH where retention was less

141 enitors undergo a series of divisions before irreversibly exiting the cell cycle and differentiating

142 ctly activating tbx16, which in turn acts to irreversibly flip a bistable switch, leading to maintena

143 termediates rapidly react with free DOPAL to irreversibly form dicatechol pyrrole adducts.

144 is observed (by stopped-flow) to rapidly and irreversibly form in this reaction (k1(-10 degrees C) =

145 cterial biofilms, the amyloid protein curli, irreversibly formed fibers with bacterial DNA during bio

146 tions reveal that the defective RBCs respond irreversibly, i.e., they lose their ability to recover t

147 On top of these films, neutravidin was irreversibly immobilized by complexing the biotin moieti

148 dentified at which SFR2 was induced prior to irreversibly impacting plant growth, suggesting that SFR

149 MRI and ion leakage revealed that cold irreversibly impairs ripening-associated membrane liquef

150 sexually dimorphic expression of CYP2C11 is irreversibly imprinted shortly after birth by a hormone

151 r biological building blocks efficiently and irreversibly in diverse architectures.

152 ological activity and was formed rapidly and irreversibly in response to increases in auxin levels.

153 bilized from IOCS, which bound both bacteria irreversibly in the absence of NOM.

154 Variant LR accumulates irreversibly in the nucleus, preventing RGS14 binding to

155 tastability built into virus the envelope to irreversibly inactivate HIV-1 and provide a conceptual p

156 xceeding 10 mJ/cm(2), which is sufficient to irreversibly inactivate most common pathogens in water w

157 on sequence of the Cas12a-bound guide RNA to irreversibly inactivate the Cas12a complex.

158 nizable group with a pK(a) of 7.0 and can be irreversibly inactivated through covalent modification b

159 -hydrogenase isoforms, HydA1 and HydA2, both irreversibly inactivated upon a few seconds exposure to

160 ll-free extracts, (iii) both activities were irreversibly inactivated upon exposure to O2, and (iv) b

161 ts phosphate backbone led to a molecule that irreversibly inactivates DNA polymerase beta in solution

162 We found that TmtA irreversibly inactivates ETP by S-alkylation and that th

163 hrombin (AT) is an anticoagulant serpin that irreversibly inactivates the clotting proteinases factor

164 Interestingly, the irreversibly inactive variant of the StI mutant StI W111

165 SOICR, whereas high levels of RyR2 oxidation irreversibly increase the threshold for SOICR leading to

166 ozymes are also increased in immune cells in irreversibly inflamed human dental pulp, and extracts of

167 synthesized and screened for the ability to irreversibly inhibit DNA polymerase beta.

168 Among them, compound RBM10-8 can irreversibly inhibit human sphingosine-1-phosphate lyase

169 s of nuclear export (SINEs) bind to CRM-1 to irreversibly inhibit its ability to export proteins; we

170 cription and provides a rational approach to irreversibly inhibit other kinases in vivo.

171 nt evidence that aspirin's unique ability to irreversibly inhibit platelet cyclooxygenase-1 is a key

172 proach offers a novel catalytic mechanism to irreversibly inhibit protein function by targeting prote

173 ble through total synthesis and are found to irreversibly inhibit sodium ion conductance in recombina

174 g anticoagulant with active metabolites that irreversibly inhibit the platelet surface GPCR P2Y12 and

175 approach, we identified cyclic peptides that irreversibly inhibited a cysteine protease and a serine

176 of of the conjugation and new chemicals that irreversibly inhibited African malaria mosquito AChE wit

177 WIN 18,446 strongly and irreversibly inhibited ALDH1A2 in vitro.

178 experiments or, less likely, 2) thrombin is irreversibly inhibited at a faster-than-expected rate, p

179 nd inducible NOS but not endothelial NOS are irreversibly inhibited by H2S/NO at modest concentration

180 However, in serum, uPlm is irreversibly inhibited by its principal inhibitor alpha2

181 inesterases (AChEs) could be selectively and irreversibly inhibited by methanethiosulfonates presumab

182 The catalytic activity of BChE could be irreversibly inhibited by organophosphorus pesticides (O

183 In comparison, the insecticide paraoxon irreversibly inhibited mosquito and human AChEs with k(i

184 Brief gemcitabine incubation irreversibly inhibited ribonucleotide reductase, depleti

185 The aromatic aldehyde o-vanillin also irreversibly inhibited the deoxygenation-induced conduct

186 es between active, reversibly inhibited, and irreversibly inhibited thrombin.

187 the inhibitor, is dragged 75 A apart, and is irreversibly inhibited.

188 more, granule products directly degrade LLO, irreversibly inhibiting its activity.

189 , it was reported that estrone-3-O-sulfamate irreversibly inhibits a new potential hormone-dependent

190 However, ibrutinib also irreversibly inhibits alternative kinase targets, which

191 ine (K731) in a time-dependent reaction that irreversibly inhibits LOXL2 and converts the trihydrophe

192 It irreversibly inhibits nicotinic acetylcholine receptors

193 Prolonged NO exposure irreversibly inhibits respiration by covalent modificati

194 fied a compound that covalently binds to and irreversibly inhibits the activity of poly(ADP-ribose) p

195 erogeneous breast cancer cell population and irreversibly inhibits the formation of free-floating mam

196 small molecule, FiVe1, which selectively and irreversibly inhibits the growth of mesenchymally transf

197 ete the virulence factor syringolin A, which irreversibly inhibits the proteasome by a novel mechanis

198 tructure-guided development of XL177A, which irreversibly inhibits USP7 with sub-nM potency and selec

199 smatodendrosis, a morphological attribute of irreversibly injured astrocytes.

200 que to exclude patients with a large area of irreversibly injured brain tissue.

201 to establish whether imaging assessments of irreversibly injured ischaemic core and potentially salv

202 (CT) perfusion, can estimate the size of the irreversibly injured ischemic core and the volume of cri

203 rly as possible, thus limiting the extent of irreversibly injured myocardium.

204 dentin-pulp interface in direct contact with irreversibly injured pulp tissue.

205 patients with large baseline ischemic cores (irreversibly injured tissue).

206 Like all retroviruses, HIV-1 irreversibly inserts a viral DNA (vDNA) copy of its RNA

207 how that Ag16Al16Si24O8.16H2O (Ag-natrolite) irreversibly inserts xenon into its micropores at 1.7 GP

208 0 exhibit a 3D layered array that transforms irreversibly into columnar periodicities during heating

209 ounts of Co(Sal(tBu,tBu))Cl and organosilane irreversibly isomerize terminal alkenes by one position.

210 ular cells are fixed progenitors, cells were irreversibly labeled before ischemia reperfusion injury

211 I-edge x-ray absorption near-edge spectra of irreversibly laser excited Molybdenum using an average o

212 ch under reaction conditions leaves probably irreversibly, leading to faster decomposition and deacti

213 as if they were overdamped because energy is irreversibly leaked into diverging nonaffine fluctuation

214 acyl-Ser and LPETGG-isoacyl-Hse) that can be irreversibly ligated to N-terminal Gly-containing moieti

215 on nanotubes (SWNTs) passively transport and irreversibly localize within the lipid envelope of extra

216 How much free energy is irreversibly lost during a thermodynamic process?

217 When hair cells are irreversibly lost from the mammalian cochlea, supporting

218 from apoptosis upon p14(ARF) induction, but irreversibly lost their ability to proliferate and initi

219 inue to allow the resource to be essentially irreversibly lost through dilution in surface waters.

220 romote regeneration of hard and soft tissues irreversibly lost to periodontitis in the Hanford miniat

221 e degenerated and light sensitivity has been irreversibly lost.

222 ible, proximity-dependent labeling system to irreversibly mark replication-dependent H3.1 and H3.2 hi

223 nnels bearing Cys at position 79 or 416 were irreversibly modified by thiol-reactive reagents in a st

224 recognition and binding, covalent inhibitors irreversibly modify a proximal nucleophilic residue on t

225 and drugs that produce biological effects by irreversibly modifying proteins.

226 -cell dependency on Kv1.3 or KCa3.1 might be irreversibly modulated by antigen exposure.

227 otent mechanism-based inhibitor and inhibits irreversibly MPO at nanomolar concentration.

228 nhibited stoichiometrically and functionally irreversibly, no strong inhibitors have been identified

229 , in European pear, the application of 1-MCP irreversibly obstructs the onset of system 2 ethylene pr

230 layer on the anode robs Li from the cathode irreversibly on an initial charge, further lowering the

231 ant mass yield in the gas phase and condense irreversibly onto aerosol surfaces to produce secondary

232 Aldehyde dehydrogenase enzymes irreversibly oxidize aldehydes generated from metabolism

233 rthermore, highly oxidative environments can irreversibly oxidize Cys-S-OH to Cys-S-sulfinic (Cys-SO(

234 -dimethyl-1-pyrroline-N-oxide, we found more irreversibly oxidized betaCys-93in HbS than in HbA.

235 Irreversibly oxidized GAPDH accumulated in stored erythr

236 Juglone is irreversibly oxidized in at least one electrode step and

237 vels, including the repair or degradation of irreversibly oxidized proteins (IOPs).

238 Removal of irreversibly oxidized, functionally compromised GAPDH id

239 le fluorescent protein tdEosFP, which can be irreversibly photoswitched from a green to red fluoresce

240 Yet, because neurons are irreversibly post-mitotic and not readily available from

241 length can lead to cellular senescence that irreversibly prevents cells from further cell division.

242 pled protease-activated receptor 1 (PAR1) is irreversibly proteolytically activated by thrombin.

243 ishingly small extent and the Rh-precatalyst irreversibly reacts with dissolved K2CO3 to form the act

244 ells in these two strains and found it to be irreversibly reduced in aging Ho_CS but sustained in non

245 ose a structural model for p.Q207D-c.a. that irreversibly relocates the GS domain into an activating

246 ochondrial activation with replication, HSCs irreversibly remodel the mitochondrial network and that

247 cellular matrix (ECM), are significantly and irreversibly remodeled by cellular traction forces, as w

248 extracellular matrix, are significantly and irreversibly remodelled by cellular traction forces and

249 ents demonstrate that training the electrode irreversibly reorders the surface.

250 shortly after birth ssTnI is completely and irreversibly replaced by the adult cardiac TnI (cTnI) is

251 to investigate whether these materials could irreversibly retain a model nanoparticle, ZnO, and if so

252 and U were reversibly sorbed, Se and Cr were irreversibly sequestered via reductive precipitation.

253 e an additional assumption that thrombin was irreversibly sequestered; we hypothesized that this coul

254 ed with a competing allene dimerization that irreversibly sequesters rhodium.

255 equired strongly electrophilic reagents that irreversibly sever bonds between native organic ligands

256 oligosaccharides can be used, with TSG-6, to irreversibly shuffle HCs from pathological, HMW HC-HA to

257 pressed in double-positive and CD4 cells but irreversibly silenced in CD8 cells.

258 tions between active, reversibly silent, and irreversibly silent states.

259 trates, which in turn remodel the matrix and irreversibly simplify the alveoli.

260 Our research suggested that Hg was irreversibly sorbed via complexation with phenolic hydro

261 ps, are also found to block channel function irreversibly; such compounds have potential as reagents

262 omain-containing transcriptional regulators, irreversibly suppressed development of type-1 diabetes i

263 l, in which tumor cells undergoing EMT would irreversibly switch their fluorescent marker from RFP(+)

264 that these inert precursors specifically and irreversibly tag any HaloTag-fused protein of interest (

265 onal transgenic mice, in which podocytes are irreversibly tagged upon tamoxifen treatment (NPHS2.iCre

266 hibitors are disclosed that additionally and irreversibly target a cysteine (Cys269) found in the enz

267 Ryanodine (Ryd) irreversibly targets ryanodine receptors (RyRs), a famil

268 echanism of action; that is, how these drugs irreversibly terminate the 'individuality' of bacterial

269 nditions of high local concentration through irreversibly tethering the two G domains together at the

270 ed drug discovery approach is reported which irreversibly tethers drug-like fragments to catalytic cy

271 position showed that the process takes place irreversibly through a polar transition state (rho = -0.

272 ivation wavelength, the oxazine ring cleaves irreversibly to bring the adjacent BODIPY fragment in co

273 compounds and a taxane that otherwise bound irreversibly to dialysis membranes and which exhibited d

274 protein when newly synthesized, which shifts irreversibly to red fluorescence when oxidized.

275 omprising four species, that bacteria adhere irreversibly to surfaces through multiple, reversibly-bi

276 Te phase becomes metastable, and can convert irreversibly to the bulk rock salt phase as the temperat

277 n of first covalent ligands designed to bind irreversibly to the CB1R allosteric site.

278 alidation of BQCA analogues designed to bind irreversibly to the M1 mAChR.

279 inactive version of the Csy4 nuclease binds irreversibly to transcripts engineered with a 16-nt hair

280 64)Cu-L19K-FDNB), which binds covalently and irreversibly to vascular endothelial growth factor (VEGF

281 g detergents, a step that can lead, possibly irreversibly, to protein denaturation.

282 al calculations suggest that 1T phase can be irreversibly transformed into a more active 1T' phase as

283 In addition, the less stable Au38T can be irreversibly transformed to the more stable Au38Q at 50

284 at uncontrolled PI3K activity within oocytes irreversibly transforms granulosa cells (GC), causing GC

285 th high concentrations of plasma capture and irreversibly trap abundant proteins.

286 During the elution step, irreversibly trapped proteins remain captured while low

287 it proved to be a reactive Michael acceptor, irreversibly trapping thiol nucleophiles, which prevente

288 s 1 can react with N2 reversibly and with CO irreversibly under photochemical conditions.

289 infrared fluorescent membrane probe that can irreversibly undergo such a switch.

290 metry analysis revealed that polymorph alpha irreversibly undergoes endothermic transition to polymor

291 ect and acidification, pH 6.4, activated TRP irreversibly, unlike the endogenous activator.

292 Interestingly, genes irreversibly upregulated by suppression of AREG overlapp

293 Photoconvertible FPs, which can be activated irreversibly via a photo-induced chemical reaction that

294 includes ions, to show that fluid can react irreversibly with eclogite at 900 degrees C and 5.0 GPa,

295 enabling the design of analogues that react irreversibly with model thiols, as well as the model pro

296 Two of them inhibit human CYP51 functionally irreversibly with their potency approaching the potencie

297 aseous H(2)O(2) levels decreased rapidly and irreversibly, with removal rate constants (k(H(2)O(2)))

298 suggests that HIV influences immune function irreversibly, with several pathways that are persistentl

299 s a medium-sized ring that forms rapidly and irreversibly without any catalyst at low muM concentrati

300 glet oxygen via a pi2 + pi4 cycloaddition to irreversibly yield a highly fluorescent endoperoxide.