ライフサイエンスコーパス: irritability

1 st step in the processes of 'sentience' and 'irritability'.

2 ued all study drugs due to an adverse event (irritability).

3 es were associated with decreasing levels of irritability.

4 ver, tachycardia, poor perfusion, and severe irritability.

5 and libido, and with anorexia, fatigue, and irritability.

6 ying the sensitisation of C-fibres in airway irritability.

7 disordered breathing and reduces ventricular irritability.

8 tems related to anger, worry, dysphoria, and irritability.

9 ious mood symptoms, ie, sadness, crying, and irritability.

10 stories of impulsive aggressive behavior and irritability.

11 y index were used as dimensional measures of irritability.

12 ts include depressive symptoms, anxiety, and irritability.

13 frustration) blocks predicted child-reported irritability.

14 as conducted to identify networks predicting irritability.

15 ression models to estimate associations with irritability.

16 s same network was associated with increased irritability.

17 s was more pronounced in young children with irritability.

18 regulation may in part underlie symptoms of irritability.

19 schizophrenia risk score with psychosis and irritability.

20 pattern associated with abnormal electrical irritability; 13 patients had abnormal nerve conduction

21 nt) with depression (20%), apathy (15%), and irritability (15%) being most common.

22 .001), anxiety (3.00; 2.01-4.48; P < .001), irritability 2.99; 2.11-4.22; P < .001), and depression

23 crocephaly (41%), nausea and vomiting (30%), irritability (24%), and lethargy (21%) for children aged

24 performed in 45 patients with mTBI (38 with irritability, 32 with depression, and 18 with anxiety).

25 (48%), fatigue (46%), drowsiness (39%), and irritability (37%); most scores indicated high distress.

26 ), disinhibition (16% versus 2%, P = 0.009), irritability (48% versus 9%, P = 0.0001), sleep changes

27 Fever (92%), irritability (84%), and clinical signs of seizures (51%)

28 stic specificity in the neural correlates of irritability, a symptom of both DMDD and bipolar disorde

29 ates consistently captured shared aspects of irritability, ADHD, and anxiety, while the third was spe

30 sed on early (baseline-to-week-2) changes in irritability after controlling for early changes in over

31 th enhancing dopamine signaling (increase of irritability, aggression, etc.), is the main cause of Ca

32 onal manifestations often including anxiety, irritability/aggression and altered sensory processing.

33 Depression, irritability/aggression and OCBs are prevalent in all st

34 Obsessive/compulsive behaviours and irritability/aggression were inversely correlated with t

35 five neuropsychiatric features: depression, irritability/aggression, obsessive/compulsive behaviours

36 ng post-traumatic stress symptoms (PTSS) are irritability, aggressive behavior, distressing memories

37 severe dysphoria, behavioural disinhibition, irritability/agitation, reduced empathy/sympathy, repeti

38 Autistic type problems and irritability also appear to show developmental variation

39 Youths with irritability also show maladaptive orienting to, interpr

40 vioral and psychophysiological correlates of irritability among children with severe mood dysregulati

41 Age moderated the association between irritability and activation in some frontal and posterio

42 ed in a sustained reduction in scores on the Irritability and Aggression subscales of the Overt Aggre

43 Given that psychiatric changes, including irritability and aggression, are common findings in HD p

44 dications are indicated for the treatment of irritability and agitation symptoms in children with aut

45 important findings if the pathophysiology of irritability and anxiety are studied in isolation.

46 Specifically, irritability and anxiety jointly influenced left amygdal

47 The child's irritability and anxiety were rated by both parent and c

48 s analyses, the shared and unique effects of irritability and anxiety were tested on amygdala functio

49 2 major dimensions of child psychopathology, irritability and anxiety, on neural responses to facial

50 n of other forms of negative affect, such as irritability and anxiety.

51 They are frequently used to treat irritability and associated behaviors including aggressi

52 The authors highlight irritability and callous behavior as two core exemplars

53 amine how the relation is affected by infant irritability and caregiving practices.

54 symptoms, including depressed mood, anxiety, irritability and craving in dependent subjects may contr

55 Dimensions of irritability and defiant behavior, though correlated wit

56 ) was significantly higher than that between irritability and delinquency (r(A)=0.57, 95% CI=0.45-0.6

57 ) was significantly higher than that between irritability and delinquency (r(A)=0.57, 95% CI=0.45-0.6

58 ic analyses, the genetic correlation between irritability and depression (r(A)=0.70, 95% CI=0.59-0.82

59 ic analyses, the genetic correlation between irritability and depression (r(A)=0.70, 95% CI=0.59-0.82

60 unted for by the genetic association between irritability and depression at wave 2.

61 the hypothesis that the association between irritability and depression is accounted for by genetic

62 y exacerbate, or even cause symptoms such as irritability and depression that are common in early sta

63 al effects underlie the relationship between irritability and depression.

64 nd bipolar disorder showed similar levels of irritability and did not differ from each other or from

65 uana relapse and reversed withdrawal-related irritability and disruptions in sleep and food intake (p

66 Irritability and fear/anxiety may be additional clinical

67 tween the two components of oppositionality (irritability and headstrong/hurtful behaviors) and depre

68 roversy exists regarding whether nonepisodic irritability and hyperarousal (severe mood dysregulation

69 severe mood dysregulation (i.e., nonepisodic irritability and hyperarousal without episodes of euphor

70 e narrower phenotypes the symptoms of severe irritability and hyperarousal.

71 (PTE) affected speech processing, levels of irritability and hypertonicity, attention levels, abilit

72 cept for a significantly greater decrease in irritability and improvement in motor inhibition in sham

73 the genetic and environmental influences on irritability and its overlap with depression.

74 side effects experienced by women using HC (irritability and lability) are not captured by a screeni

75 In PMDD, irritability and mood swings are tied more closely to pr

76 thic electromyogram with abnormal electrical irritability and muscle biopsy findings of myofibrillar

77 RI) paradigm to examine associations between irritability and neural activation and tested the modera

78 Irritability and psychoticlike symptoms at entry were si

79 t of children exhibiting chronic nonepisodic irritability and severe temper outbursts.

80 In conclusion, irritability and SI were consistently linked in adults w

81 bacute encephalopathy with motor regression, irritability and stupor or coma resulting in major handi

82 aluated the longitudinal association between irritability and suicidal ideation (SI) in adults with m

83 Associations between irritability and suicidality and the impact of cultural

84 that is, those who have severe, nonepisodic irritability and the hyperarousal symptoms characteristi

85 py was significantly predictive of change in irritability and verbal and direct assault.

86 s known about genetic influences on juvenile irritability and whether such influences are development

87 Irritability and/or anxiety influenced amygdala connecti

88 .95), owing to the elimination of the items "irritability" and "agitation."

89 motionality (increased stress reactivity and irritability) and addictive behaviors.

90 equate growth, reduced reporting of colic or irritability, and a lower frequency of antibiotic use.

91 We obtained ratings of anxiety, irritability, and ADHD, and 10 minutes of resting-state

92 CWS includes symptoms such as agitation, irritability, and aggression, and typically peaks after

93 Impaired cognition, irritability, and agitation are also common.

94 We included factors of mixed/mania, irritability, and anxiety/depression (29 months post MRI

95 anifests with pediatric symptoms of anxiety, irritability, and attention-deficit/hyperactivity disord

96 s diverse symptoms like physical aggression, irritability, and delinquency.

97 ron therapy include myalgias, fever, nausea, irritability, and depression.

98 1 or more elevated subscales (inflexibility, irritability, and difficulty with routines) at 6 months.

99 rted high levels of household strain, social irritability, and financial strain as well as limitation

100 Mood symptoms--anxiety, irritability, and mood lability--had the lowest coeffici

101 Three mood symptoms--anxiety, irritability, and mood lability--were the most stable sy

102 , respectively, including fatigue, insomnia, irritability, and rash/pruritus.

103 ulsive disorder, tics, anxiety, mood swings, irritability, and restricted eating is described in chil

104 reativity, connectedness, energy, happiness, irritability, and wellness on dose days compared with no

105 sion, anger-hostility, dissociation, "limbic irritability," and drug use.

106 ies as well as moderately strong links among irritability (anger), concentration deficits, and sleep

107 -sectional investigations and indicates that irritability/anger during MDEs is a highly prevalent cli

108 Overt irritability/anger was present in 292 of 536 participant

109 e without current comorbid overtly expressed irritability/anger.

110 ion, included reductions in the frequency of irritability, anxiety, and delusions; among patients who

111 ower total withdrawal symptom score and less irritability, anxiety, craving, and restlessness than pl

112 routines (aOR, 1.70; 95% CI, 1.10-2.65) and irritability (aOR, 1.70; 95% CI, 1.03-2.82).

113 routines (aOR, 1.64; 95% CI, 1.05-2.57), and irritability (aOR, 1.86; 95% CI, 1.13-3.08) than childre

114 vey items related to anger, self-confidence, irritability, appetite, and interest in leisure activiti

115 Genetic effects on irritability are developmentally dynamic from middle chi

116 fever, upper respiratory tract symptoms, and irritability are less useful.

117 lementary conceptualizations of pathological irritability are proposed: 1) aberrant emotional and beh

118 Youth irritability as reported by parents is a specific predic

119 odel analyses were used to assess changes in irritability (as measured with the five-item irritabilit

120 ficantly in post hoc analysis of anxiety and irritability, as well as GI health, after 8 weeks of tre

121 and parent-reported affect dysregulation and irritability at 11 months.

122 Irritability at follow-up was assessed using the Affecti

123 sectional and longitudinal associations with irritability at follow-up were evaluated using generaliz

124 thinning within nine networks was related to irritability at follow-up.

125 l models, the phenotypic association between irritability at wave 2 and depression at wave 3 was acco

126 y cerebellar and cerebral atrophy, seizures, irritability, ataxia, and extreme spasticity.

127 ted with irritability, with higher levels of irritability being associated with thinner cortex.

128 ncy (beta -0.032, OR 1.10 [1.02-1.20]), more irritability (beta 0.032, OR 1.07 [1.01-1.14]), and more

129 Irritability (beta = 0.12, P = .03) and fear and/or anxi

130 y decreased locomotor activity and increased irritability but had no effect on sexual behavior, partn

131 eneity correlates with increased ventricular irritability by programmed electrical stimulation.

132 tate cancer is followed by bowel and bladder irritability, by increasingly severe sexual dysfunction

133 cally and pathophysiologically distinct, yet irritability can be a clinical feature of both illnesses

134 ation had a slower progression in chorea and irritability compared with those not taking such medicat

135 Behavioral measures included locomotion, irritability, copulation, partner preference, and aggres

136 Following frustration, levels of irritability correlated with activity in neural systems

137 Irritability correlated with amygdala activity across al

138 scent Development reported on the children's irritability, defined using a previously identified scal

139 01), including effects on withdrawal-related irritability, depression, and cannabis cravings.

140 sorder characterized by personality changes, irritability, depression, seizures, memory loss and some

141 ncluded dissociation and symptoms of "limbic irritability," depression, anxiety, and anger-hostility.

142 Youth irritability did not predict bipolar disorder or axis II

143 mine whether the neural mechanisms mediating irritability differ between bipolar disorder and DMDD, u

144 ild Behavior Checklist: physical aggression, irritability, disobedient behavior, and delinquent behav

145 sample of 195 youths with varying levels of irritability (disruptive mood dysregulation disorder, N=

146 ut the trial between irritability (five-item irritability domain of Concise Associated Symptom Tracki

147 irritability (as measured with the five-item irritability domain of the Concise Associated Symptom Tr

148 5% CI, 0.96-1.25] points; P = .02) and Anger/Irritability DRSP subscale score (1.22 [95% CI, 1.05-1.4

149 tivation analyses revealed associations with irritability during attention orienting following frustr

150 In contrast, in youth with low irritability, elevated Deltat(0) was associated with str

151 prodromal symptoms (e.g. sleep disturbance, irritability etc.).

152 Because youths with irritability exhibit exaggerated responses to frustratin

153 ported depression severity predicted greater irritability factor score.

154 n and hyperactivity-impulsivity, whereas the irritability factor shared genetic influences uniquely w

155 severe epilepsy including infantile spasms, irritability, failure to thrive, and stereotypic hand mo

156 ent association throughout the trial between irritability (five-item irritability domain of Concise A

157 = 9) presented in early infancy with severe irritability, followed by dystonia and stagnation of dev

158 growth restriction, infantile hypotonia, and irritability, followed by failure to thrive and short st

159 d environment was not a primary influence on irritability for males or females.

160 Irritability has been proposed to underlie the developme

161 question of whether social communication and irritability have the same meaning at different ages.

162 xiety (hazard ratio=1.87, 95% CI=1.28-2.73), irritability (hazard ratio=1.84, 95% CI=1.31-2.58), and

163 ated to visual hallucinatory experiences and irritability, implying that these experiences become mor

164 Parents and physicians reported less irritability, improved alertness, or both in seven patie

165 If abused, such steroids can cause irritability, impulsive aggression, and signs of major d

166 with behavioural disorders characterized by irritability, impulsiveness, bizarre alterations in dres

167 vity during frustrative nonreward to predict irritability in a transdiagnostic sample.

168 baseline emotional and behavioral disorders, irritability in adolescence predicted major depressive d

169 Parent-reported irritability in adolescence was used to predict self-rep

170 Cross-sectionally, irritability in adolescence was widely associated with o

171 the potential usefulness of NAC for treating irritability in children with autistic disorder.

172 inhibition may contribute to impulsivity and irritability in children with bipolar disorder.

173 The role of irritability in developmental psychiatry, and in the pat

174 les, with new genetic risk factors affecting irritability in early and late adolescence for males.

175 ttle is known about the relationship between irritability in early life and its outcomes in mid-adult

176 Irritability in pediatric samples is associated with hig

177 These findings support careful assessment of irritability in suicide risk assessment.

178 to evaluate different approaches to treating irritability in the two disorders.

179 ia was associated with significantly greater irritability in univariate regression models (for more t

180 community samples indicate that nonepisodic irritability in youths is common and is associated with

181 dysfunction to improve treatment for severe irritability in youths.

182 associated with higher levels of depression, irritability, inattention, and hyperactivity.

183 e hypothesis that there are several forms of irritability, including a "neurodevelopmental/ADHD-like"

184 As males age, genetic influences on irritability increase while nonshared environmental infl

185 ionally associated with depressive symptoms, irritability, increased right cerebellum exterior volume

186 a particular profile of poorer cognition and irritability independent of ADHD.

187 eficiency have included depression, anxiety, irritability, insomnia, weakness, diminished libido, imp

188 Childhood irritability is a common, impairing problem with changin

189 Researchers disagree as to whether irritability is a diagnostic indicator for pediatric man

190 Irritability is a widely occurring DSM-IV symptom in you

191 Although irritability is among the most common reasons that child

192 Irritability is an important dimension of psychopatholog

193 Results indicate that while irritability is an important feature of severe mood dysr

194 Irritability is an important symptom domain of major dep

195 As irritability is associated with reactive aggression, the

196 This report evaluated whether irritability is associated with SI at the same visit (i.

197 Collectively, these findings suggest that irritability is associated with widespread reductions in

198 Irritability is common in children and adolescents and i

199 his study examines the extent to which youth irritability is related to adult psychiatric outcomes by

200 ratio=0.40), anxiety (odds ratio=0.43), and irritability/lability (odds ratio=0.38).

201 he Aberrant Behavior Checklist subscales for irritability, lethargy/social withdrawal, and hyperactiv

202 itioned to produce migraine symptoms such as irritability, loss of appetite, fatigue, depression, or

203 rvasive antisocial character traits, such as irritability, manipulativeness, and lack of remorse.

204 The developmental context of irritability may be important in its conceptualization:

205 ts conceptualization: early-onset persistent irritability may be more neurodevelopmental/ADHD-like an

206 ype bipolar disorder, the pathophysiology of irritability may differ among the groups and is influenc

207 essed mothers with high anxious distress and irritability may require medications that reduce these s

208 For affective symptoms (anxiety, sadness, irritability, mood swings), there were significant main

209 neurodevelopmental/ADHD-like and later-onset irritability more depression/mood-like.

210 lessness, fatigue, difficulty concentrating, irritability, muscle tension, or sleep disturbances).

211 arly perimenopausal women had higher odds of irritability, nervousness, and frequent mood changes but

212 ALS is characterised by personality change, irritability, obsessions, poor insight, and pervasive de

213 vents (transiently increased perspiration or irritability) occurred in six (13%) patients.

214 th improvements in the choreic movements and irritability of HD but worsens cognition.

215 utward currents could also contribute to the irritability of the central nervous system typical of cl

216 maternal stroking was associated with higher irritability, only in the mismatched, low-high and high-

217 reased rates of behavior problems, including irritability, oppositional defiant behavior, conduct dis

218 Although symptoms of irritability or anger are not central to the diagnosis o

219 escence, unit experiences, health, injuries, irritability or anger, personality, emotional problems,

220 a extend prior work conducted in youths with irritability or anxiety alone and suggest that research

221 ining sleep, accompanied by symptoms such as irritability or fatigue during wakefulness.

222 ts, and more days in the preceding year with irritability or mood elevation.

223 ome characterized by episodic acute onset of irritability or neurological deficits between 2 months a

224 od regulation problems in the form of either irritability or short episodes of mania-like symptoms in

225 regulation problems, such as severe chronic irritability or short episodes of mania-like symptoms, a

226 esses may be effective for cases with severe irritability or short episodes of mania-like symptoms.

227 he evidence base for the treatment of either irritability or short-lived episodes of mania-like sympt

228 characteristic of asthma is increased airway irritability, or bronchial hyperresponsiveness (BHR) whi

229 was not associated with physical aggression, irritability, or disobedient behavior.

230 ania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is assoc

231 uch as mood stabilizers, which dampen limbic irritability, or selective serotonin reuptake inhibitors

232 T alone had no effect on locomotion, irritability, or sexual behavior but increased partner p

233 with a lower frequency of reported colic or irritability (P < 0.001) and a lower frequency of antibi

234 or nervousness (P<.02), depression (P<.03), irritability (P<.01), and the overall behavioral symptom

235 ion, depressed state, sleep disturbance, and irritability/paranoia.

236 itory hallucinations, visual hallucinations, irritability, personality change, and rapid eye movement

237 Greater baseline-to-week-2 reductions in irritability predicted lower levels of subsequent SI; es

238 Irritability, presumably secondary to pain or headache d

239 her PBA-HD scores on depression, apathy, and irritability (range, P = 0.01-0.005).

240 we examined how transdiagnostic symptoms of irritability relate to the development of structural bra

241 tional anisotropy were seen in patients with irritability relative to control subjects.

242 Aggression, anger, irritability, restlessness, and strange dreams increased

243 threat are central to the pathophysiology of irritability, revealing important translational opportun

244 Clinicians and researchers should assess irritability routinely, and specific assessment tools ar

245 (RR = 2.19), forgetfulness (RR = 2.56), and irritability (RR = 2.73).

246 in outcome measures were the DRF symptoms of irritability, sadness, and anxiety.

247 reduction in several core PMDD symptoms (ie, irritability, sadness, anxiety, food cravings, and bloat

248 ned as at least a 25 percent decrease in the Irritability score and a rating of much improved or very

249 resulted in a 56.9 percent reduction in the Irritability score, as compared with a 14.1 percent decr

250 y and maternal stroking in the prediction of irritability, seen only in girls.

251 lly in diabetic patients, such as confusion, irritability, seizure and can even be fatal in specific

252 elessness, anhedonia/lack of energy, anxiety/irritability, self-reproach, disturbed sleep, agitation/

253 A major issue is how irritability should be conceptualized.

254 al and genetic findings suggest that chronic irritability should be regarded as a mood problem that i

255 Irritability showed a significantly stronger phenotypic

256 f frustration, children with severe, chronic irritability showed abnormally reduced activation in reg

257 terised by feelings of threat, restlessness, irritability, sleep disturbance, and tension, and sympto

258 degrees F, pericardial friction rub, patient irritability, small pericardial +/- pleural effusion.

259 search is needed to relate these findings to irritability specifically, rather than to other clinical

260 Meanwhile, symptoms of irritability (strength, betweenness, or bridge centralit

261 ompared with 22% [SD=32]) and the DRSP anger/irritability subscale (47% [SD=21] compared with 23% [SD

262 resulted in significant improvements on ABC irritability subscale (F = 6.80; p < .001; d = .96).

263 ry outcomes: the Aberrant Behavior Checklist-Irritability subscale (range, 0-45) and the Home Situati

264 der (age 18-45 years; full scale IQ >70; ABC-Irritability subscale 13).

265 At week 24, the Aberrant Behavior Checklist-Irritability subscale declined 47.7% in parent training

266 imary outcome measures were the score on the Irritability subscale of the Aberrant Behavior Checklist

267 l measure (Aberrant Behavior Checklist [ABC] irritability subscale) and safety measures were performe

268 om clusters (depressive, physical, and anger/irritability symptoms).

269 Mood and behavioural symptoms, including irritability, tension, depressed mood, tearfulness, and

270 , the authors present a mechanistic model of irritability that integrates clinical and translational

271 ache, sleep disturbance, inability to relax, irritability) that does not resolve by resting or relaxi

272 administration sessions, and withdrawal-like irritability through the bottle brush test.

273 athology during their lifetime, varying from irritability to psychosis, but prevalences of particular

274 Irritability trajectory classes were estimated for 7,924

275 Five irritability trajectory classes were identified: low (81

276 tern of genetic and environmental effects on irritability using data from a prospective, four-wave lo

277 ith high levels of anxiety but low levels of irritability (Wald chi21 = 21.3; P < .001 for contrast).

278 uch thoughts on a subsequent survey, greater irritability was also associated with greater likelihood

279 Irritability was associated with differences in neural r

280 Higher irritability was associated with higher SI concurrently;

281 Greater irritability was associated with likelihood of thoughts

282 dication use, and total intracranial volume, irritability was associated with smaller volumes in prim

283 In linear regression models, irritability was greater among respondents who were fema

284 Irritability was measured by parent and child reports on

285 Specifically, higher irritability was more strongly related to increased acti

286 Irritability was positively associated with frontal-stri

287 In the CO-MED trial, irritability was significantly reduced (effect size=1.06

288 At 6 weeks old, irritability was the most common systemic solicited reac

289 premenstrual-related tiredness, sadness, and irritability were assessed twice over 6 years in 1,312 m

290 am, associations between neural activity and irritability were found more consistently in the DMDD gr

291 n, anger-hostility, dissociation and 'limbic irritability' were assessed by rating scales.

292 Early reductions in irritability, when combined with changes in depressive s

293 ociated with high levels of both anxiety and irritability, whereas increased connectivity was associa

294 Developmental trajectories of irritability (which may begin early in life) have been i

295 Irritability, which is strongly associated with impairme

296 The authors evaluated improvement in irritability with antidepressant treatment and its progn

297 , concurrently) and whether early changes in irritability with antidepressant treatment predict subse

298 Both link to discrete pathophysiology: irritability with disruptions in prefrontal regulation o

299 24 covariance networks were associated with irritability, with higher levels of irritability being a

300 othesized that during face emotion labeling, irritability would be associated with dysfunctional acti