ライフサイエンスコーパス: irritants

1 ncluding mechanical stimulation and chemical irritants.

2 iggers such as allergens, microorganisms and irritants.

3 and the presence of inhalable pollutants and irritants.

4 tinel for structurally diverse electrophilic irritants.

5 f environmental exposures like allergens and irritants.

6 ough and a heightened sensitivity to inhaled irritants.

7 ether with neurons to identify itch-inducing irritants.

8 airway defense against inhaled pathogens and irritants.

9 of different weak sensitizers / addition of irritants.

10 econd study focused on EHR use and daily EHR irritants.

11 to a plethora of pathogens and environmental irritants.

12 eference contact allergens and nonallergenic irritants.

13 in increased penetrability to allergens and irritants.

14 xposure to allergens, pathogens, or chemical irritants.

15 rs chronically exposed to moderate levels of irritants.

16 after chronic exposure to moderate levels of irritants.

17 ons or exposure to allergic and non-allergic irritants.

18 hagous fluids, environmental xenobiotics and irritants.

19 ent of TRPA1, a key sensor for environmental irritants.

20 matory responses to cutaneous and peritoneal irritants.

21 y airway exposures to allergens and chemical irritants.

22 ell as environmental and endogenous chemical irritants.

23 pungent natural compounds and environmental irritants.

24 y for behavioral responses to these chemical irritants.

25 nd mediates behavioral responses to chemical irritants.

26 pungent natural compounds, and environmental irritants.

27 ion of nociceptors by endogenous and natural irritants.

28 mach less susceptible to damage from luminal irritants.

29 lvents, welding fumes, and other respiratory irritants.

30 hich respond to numerous odorants as well as irritants.

31 tinocytes treated with certain allergens and irritants.

32 es to protect the host against pathogens and irritants.

33 oxyethylene) ammonium chloride (ITDOP); mild irritants: 5% 3-decyloxypropyl-bis(polyoxyethylene) amin

34 Test materials included slight irritants: 5% sodium lauryl sulfate (SLS), polyoxyethyle

35 o enhance permeability and susceptibility to irritants; accordingly, increased attention should be gi

36 rritation response in mice elicited by smoke irritants (acrolein, acetic acid, and cyclohexanone).

37 Sensitizers and irritants activate IRE-1 and PERK in murine and human ke

38 ral, bacterial, and nonmicrobial (toxins and irritants) agents, resulting in production of many diffe

39 s sneezing responses to a multitude of nasal irritants, allergens, and viruses.

40 rosols with increasing doses of the chemical irritants allyl isothiocyanate (AITC; also known as must

41 nded chemical data set, comprising five skin irritants and 11 contact allergens.

42 s can affect airway inflammatory response to irritants and allergens, but the importance of stress in

43 r challenges, including allergens, exercise, irritants and aspirin.

44 uction machinery through which environmental irritants and endogenous proalgesic agents depolarize no

45 ormal breathing by a myriad of environmental irritants and infectious insults.

46 cautions should be taken against respiratory irritants and molds and to prevent children from becomin

47 one of the primary sensors of environmental irritants and noxious substances.

48 acts as a sensory receptor for environmental irritants and oxidants.

49 echanism that aids in the removal of harmful irritants and parasites(1).

50 tion following long-term exposure to harmful irritants and pollutants, particularly in the airways.

51 el is the molecular target for environmental irritants and pungent chemicals, such as cinnamaldehyde

52 is the first body surface to contact inhaled irritants and report danger.

53 catnip and nepetalactone as insect-selective irritants and suggest that, despite TRPA1's broad conser

54 hat they can be activated by various inhaled irritants and/or cold air.

55 condary ozonides (SOZ), which are known skin irritants, and a modest change in particle size.

56 rs in the newborn's intestine, pathogens and irritants, and allergens in food.

57 t recognize pathogens, chemical and physical irritants, and damaged cells subsequently initiating a w

58 associated molecular patterns, environmental irritants, and endogenous stimuli released from dying ce

59 host from toxins, xenobiotics, environmental irritants, and helminthic parasites, and (3) IgE-stimula

60 er that allows the penetration of allergens, irritants, and microbes into a cutaneous milieu that fac

61 on, and extrinsic stimuli such as allergens, irritants, and microbes.

62 of the circadian clock, escape responses to irritants, and multi-parameter day-night locomotor behav

63 PCR analyses of multiple chemical allergens, irritants, and non-sensitizers have identified 10 genes

64 entions to reduce exposures to allergens and irritants, and research on the underlying mechanisms tha

65 unters with allergens, pathogens, wounds and irritants, and to react more quickly to the next experie

66 multiple symptomatic high-level exposures to irritants; and (iii) possible IIA, that is asthma occurr

67 Receptors for trigeminal irritants are generally assumed to be located exclusivel

68 ctivated by noxious heat, acid, and alkaloid irritants as well as several endogenous ligands and is s

69 to a wide spectrum of noxious electrophilic irritants, as well as cold, heat, and mechanosensation.

70 ons to aeroallergens, contact allergens, and irritants at days 2, 3, and 4.

71 side' world from potentially harmful toxins, irritants, bacteria and other pathogens that also exist

72 gions in the mouth are uniquely sensitive to irritants because they can penetrate through the tissue

73 s sensory detection of pathogens, toxins and irritants; breakdown of the epithelial barrier is associ

74 ubstances, toxins, venoms, and environmental irritants but that also trigger exuberant allergic react

75 diverse array of environmental and microbial irritants by forming the barrier of epithelial cells int

76 Detection of such irritants by the trigeminal nerve evokes protective refl

77 Airway irritants cause a variety of lung pathologies.

78 rs after treatment, mild and moderate ocular irritants caused a significant increase in corneal thick

79 he epithelium, whereas the mild and moderate irritants caused complete epithelial cell loss with incr

80 On day 1, mild, moderate, and severe irritants caused complete loss of epithelium and disappe

81 nflammation via hapten-specific T cells) and irritants (chemicals that are toxic to epidermal cells).

82 tinocytes treated with certain allergens and irritants, compared with untreated keratinocytes.

83 and bulb may provide an avenue whereby nasal irritants could affect processing of coincident olfactor

84 nasal epithelium, requiring that trigeminal irritants diffuse through the junctional barrier at the

85 s are activated by noxious stimuli including irritants (e.g. TRPV1 agonist capsaicin) and inflammator

86 ave been identified, including environmental irritants (e.g., acrolein) and ingredients of pungent na

87 (e.g., allyl isothiocyanate), environmental irritants (e.g., acrolein), and endogenous ligands (4-hy

88 nerve endings can detect certain lipophilic irritants (e.g., mints, ammonia), the epithelium also ho

89 g shakes for removal of water and mechanical irritants from back hairy skin.

90 n excitatory ion channel targeted by pungent irritants from mustard and garlic.

91 imilarly evokes a scratch response to remove irritants from the skin.

92 , called wet dog shakes, to remove water and irritants from their back hairy skin.

93 s, microbial products and sterile endogenous irritants governs whether the outcome will be with suppr

94 Several irritants have been documented in cases of PCOM, and a h

95 Plant-derived irritants have predominated in this regard, but animal v

96 s environmental agents (such as microbes and irritants) have been implicated in CRS.

97 oreign organisms, damaged cells and physical irritants; however, inappropriately triggered or sustain

98 o screen the existence of gingivitis and its irritants, i.e., dental calculus and soft deposits, from

99 vironmental and occupational sensitizers and irritants in its pathogenesis and the interaction with b

100 Here, we studied reflex responses to irritants in normotensive Wistar-Kyoto (WKY) rats and sp

101 exposed to a range of physical and chemical irritants in the environment that are known to trigger a

102 eurons and are activated by several chemical irritants in vitro.

103 igeminally mediated reflex reactions to some irritants including acyl-homoserine lactone bacterial qu

104 rrier to allergens as well as other external irritants including infectious agents, and atmospheric p

105 Environmental air irritants including nanosized carbon black (nCB) can dri

106 where it acts as a sensor for environmental irritants, including acrolein, and some pungent plant in

107 well as for detecting electrophilic sensory irritants, including allyl isothiocyanate.

108 nd to contain significantly more respiratory irritants, including NO(x), CO, and CO(2), and a larger

109 ensor for structurally diverse electrophilic irritants, including small volatile environmental toxica

110 mediators and to a diverse array of volatile irritants, including those found in tear gas and garlic.

111 The activation of TRPA1 by luminal irritants is enhanced when the protective mucus layer is

112 Control of environmental allergens and irritants is essential.

113 injury, information on possible etiology of irritants is very important.

114 ature of bronchial asthma, and inhalation of irritants may facilitate development of nonallergic AHR.

115 These data suggest that allergens and irritants may, in part, break peripheral tolerance by th

116 , but not prevented, by elimination of local irritants, meticulous oral hygiene, and regular periodon

117 ave examined in vivo and in vitro effects of irritants, most focused on events developing hours to da

118 Do ancient microbial irritants offer early life protection against diabetes?

119 itial management includes avoiding causative irritants or allergens (e.g., by wearing impermeable glo

120 Itching, induced by irritants or allergens that stimulate pruriceptive neuro

121 s) may increase the risk of LRI by acting as irritants or through increasing susceptibility to infect

122 and clears the airways and lungs of inhaled irritants, particulates, pathogens, and accumulated secr

123 ionarily as an adaptive defense against skin irritants, pathogens, or parasites.

124 Inhalation of noxious irritants/pollutants activates airway nociceptive affere

125 eated skin contact with contact allergens or irritants, resulting in allergic contact dermatitis (ACD

126 endogenous danger signals and environmental irritants, resulting in the formation and activation of

127 On day 1, mild and moderate irritants showed increasing stromal cell death from 9.8+

128 ess C5aRs and that exposure to environmental irritants such as cigarette smoke modulates the expressi

129 Various irritants such as foods, chemicals, friction, thermal/me

130 Oxidative stresses from irritants such as hydrogen peroxide and ozone (O(3)) can

131 de range of allergens, infectious agents and irritants (such as pollutants) occurring indoors and out

132 s and responds to a wide variety of chemical irritants, such as acrolein in smoke or isothiocyanates

133 TRPA1 is also targeted by environmental irritants, such as acrolein, that account for toxic and

134 This contrasts with most other common oral irritants, such as cinnamaldehyde, capsaicin, and alcoho

135 rodentium but not to that caused by chemical irritants, such as dextran sodium sulfate.

136 Inhalation of irritants, such as toluene diisocyanate (TDI), stimulate

137 ildren are exposed to multiple environmental irritants, such as viruses and allergens, that are commo

138 emically disparate animal- and plant-derived irritants target the same key allosteric regulatory site

139 cle beginning on page 2574), have identified irritants that activate transient receptor potential cat

140 Aldehydes are known carcinogens and irritants that can negatively impact health.

141 In response to infections and irritants, the respiratory epithelium releases the alarm

142 With the slight ocular irritants there was little or no change in corneal thick

143 can be activated by exogenous electrophilic irritants through direct covalent modification, we reaso

144 ized epithelial chemosensors that respond to irritants through the canonical taste transduction casca

145 vivo CM revealed corneal injury with slight irritants to be restricted to the epithelium, whereas th

146 ted by reactive environmental and endogenous irritants to initiate pain perception, local inflammatio

147 Thus, in CF, the reduced ability of mucosal irritants to stimulate airway gland secretion via SubP m

148 Multiple inhaled irritants trigger the release of complement components,

149 , that is activated by a variety of reactive irritants via the covalent modification of cysteine resi

150 psies against four contact allergens and two irritants were analyzed via microarray.

151 hannels are activated by chemically reactive irritants, whereas snake and Drosophila TRPA1 orthologs

152 single or multiple high-level exposure(s) to irritants, whereas this relationship can only be inferre

153 n were induced by both contact allergens and irritants; whereas only contact allergens prompted stron