ライフサイエンスコーパス: irritation

1 ia and frequency but no vaginal discharge or irritation).

2 ent discontinued NOV03 because of an AE (eye irritation).

3 A105 and placebo groups (2 cases each of eye irritation).

4 ly more pronounced (P < 0.0001) 5 days after irritation.

5 confirmed the absence of local erythema and irritation.

6 y during saline distension but not during AA irritation.

7 e exposure to metal ions that can cause skin irritation.

8 ificant leakage into the circulation or skin irritation.

9 stress, inflammation, and symptoms of ocular irritation.

10 particularly headaches, dizziness, and skin irritation.

11 ons and varied depending on the mode of skin irritation.

12 ere shoulder pain secondary to diaphragmatic irritation.

13 me (FES) presents nonspecific ocular surface irritation.

14 um and were subjected to repeated mechanical irritation.

15 approximately 100-fold without inducing skin irritation.

16 ight represent a local reaction to trauma or irritation.

17 with minimal associated discomfort and skin irritation.

18 it can be associated with significant ocular irritation.

19 otein expression after generalised meningeal irritation.

20 ility, pharmacological activity, and gastric irritation.

21 was induced in cortical arterioles by laser irritation.

22 ient increase in skin SNA due to local nasal irritation.

23 ctants producing different degrees of ocular irritation.

24 tants that caused different levels of ocular irritation.

25 entual repair processes after accidental eye irritation.

26 alues, and there was no coughing or tracheal irritation.

27 a Lawsone-containing cream ameliorates skin irritation.

28 in association with inflammation and chronic irritation.

29 nt growth of granulation tissue secondary to irritation.

30 offered potential for long-term use without irritation.

31 vely with chronic endothelial cell trauma or irritation.

32 innervating the airways and perceived airway irritation.

33 omarkers to distinguish contact allergy from irritation.

34 often" or "constant" symptoms of dryness and irritation.

35 ues and potential for reduced ocular surface irritation.

36 G(TM) to attenuate and/or prevent esophageal irritation.

37 may be useful to counteract HQ-induced skin irritation.

38 sights into the mechanism of HQ-induced skin irritation.

39 and signs and/or symptoms of ocular surface irritation.

40 d number of children who had sunburn or skin irritation.

41 the placebo group), mouth edema, and throat irritation.

42 ility during urinary bladder inflammation or irritation.

43 onditions of urinary bladder inflammation or irritation.

44 ecreted by slugs indicating moderate mucosal irritation.

45 sue layers of the skin without inducing skin irritation.

46 effects such as contact dermatitis and skin irritation.

47 ient required enucleation for chronic ocular irritation.

48 ly from the netarsudil arm because of ocular irritation.

49 nt arm withdrew because of drug-related skin irritation.

50 se events in the azithromycin group were eye irritation (1.9%), conjunctival hyperemia (1.1%), and wo

51 ndard dose vs high dose: urinary obstruction/irritation (23.3 [13.7] vs 24.6 [14.0]; P = .36), urinar

52 slight increase in minor self-reported skin irritation (231 [4%] of 5429 in intervention group vs 79

53 No serious AEs were reported, and eye irritation (3.7 %; n = 7/191) was the most common treatm

54 molol patients reported ocular pain/stinging/irritation (4.4% vs 4.6%) and pruritus (2.5% vs 1.5%).

55 Pain/irritation (42%), palpable mass (27%), and fever (12%) w

56 on, 20.8 to 22.8 for urinary obstruction and irritation, 9.7 to 10.5 for urinary incontinence, and 5.

57 subjective symptoms of throat tickle and/or irritation (92.1%), cough (78.5%), shortness of breath (

58 ver, HQ treatment can evoke substantial skin irritation, a side effect that remains poorly understood

59 in has suffered from problems such as tissue irritation, abscesses, discomfort, and inconvenience.

60 nsations and pain associated with mechanical irritation accompanying many ocular surface disorders.

61 oplankton cell count was associated with eye irritation [adjusted odds ratio (OR) = 1.30; 95% confide

62 Its pathogenesis involves chronic epithelial irritation, although the factors involved in the inflamm

63 Both chromic gut irritation and 10gf compression produced ipsilateral inc

64 losporine triggered mild to moderate corneal irritation and a temporary elevation in tearing.

65 ificant postoperative pain due to mechanical irritation and associated inflammation.

66 velop corneal opacity and eye lesions due to irritation and constant scratching.

67 cal insertion, which often results in tissue irritation and damage.

68 with dry eye or reported significant ocular irritation and dryness were analyzed.

69 this autocoid may play a part in the airway irritation and dyspneic sensation associated with airway

70 y play a part in the manifestation of airway irritation and excessive cough under those pathophysiolo

71 de effects of ATRA treatment, including skin irritation and hair loss.

72 the parent compounds, yet free of tail vein irritation and histamine induced toxicity in vivo.

73 come several of the adverse effects, such as irritation and hyper- or hypo-pigmentation.

74 he skin with strong adhesives that can cause irritation and iatrogenic injuries during removal.

75 irming the presence of haptic-induced ocular irritation and in assisting the management of these pati

76 f distinct phenotypes, potentially linked to irritation and infections for the transient phenotypes a

77 ncers arise from sites of infection, chronic irritation and inflammation.

78 Aspirin products are known to cause irritation and injury to the gastric mucosa.

79 Eight of the 10 volunteers had tracheal irritation and intermittent coughing following exposure.

80 correlated with ocular surface staining and irritation and inversely correlated with TBUT.

81 uirement for multiple dosing per day, ocular irritation and limited options for drugs with different

82 ubcutaneous drug administration system (site irritation and local infection).

83 Both chemical irritation and mechanical compression affect radicular p

84 cient programmable devices with minimal skin irritation and no skin barrier disruption would open an

85 inary incontinence was observed, but urinary irritation and obstruction improved, particularly in pat

86 onal outcomes (urinary incontinence, urinary irritation and obstruction, bowel, sexual, and vitality

87 h more rapid TBUT and blink rate and greater irritation and ocular surface dye staining with 1 or bot

88 Tear EGF and the severity of irritation and ocular surface signs were correlated.

89 The most frequent AEs were throat irritation and oral pruritus.

90 ntion of dosage forms, and the potential for irritation and other adverse reactions.

91 rrhoidal symptoms (rectal bleeding, perianal irritation and prolapse), the best option for treatment

92 fferent ways, ranging from respiratory tract irritation and pulmonary edema in severe cases to constr

93 position with ocular protection but reported irritation and redness in their right eyes after the ope

94 ug dosage such as avoiding gastro-intestinal irritation and slowing veterinary antibiotic resistance.

95 i1(-/-) mice were small in size, with eyelid irritation and sporadic hair loss resembling the cyclica

96 e weekly was associated with minimal bladder irritation and tolerable myelosuppression.

97 ial barrier function is the cause for ocular irritation and visual morbidity in dry eye disease.

98 fect on itch, potentially because of counter-irritation and/or distraction.

99 elia served by the trigeminal nerve produces irritation and/or pain by activating neuronal nicotinic

100 gh, throat irritation, and instillation site irritation) and were reported by fewer patients in the v

101 ned for vasovagal reactions, nerve injuries (irritations), and arterial puncture.

102 copal reactions, antecubital nerve injuries (irritations), and arterial punctures, and the medical ou

103 re fiber, (2) evidence of prolonged chemical irritation, and (3) hyper-fibrillosis about the suture w

104 for urinary incontinence, 5 to 7 for urinary irritation, and 4 to 6 for bowel and hormone function.

105 ar more susceptible to signs of ocular pain, irritation, and anxiety in response to aqueous tear defi

106 isocyanates induce lacrimation, pain, airway irritation, and edema.

107 tudies highlight concerns over oral dryness, irritation, and gingival diseases.

108 ere mild, nonocular (sneezing, cough, throat irritation, and instillation site irritation) and were r

109 ontain excipients that cause local toxicity, irritation, and leakage.

110 demonstrate a general increase in IC, pain, irritation, and light sensitivity are associated with in

111 ed adverse events were oral pruritus, throat irritation, and nasopharyngitis.

112 PAP and MADs included oral or nasal dryness, irritation, and pain, among others.

113 all emotions), and for expressions of anger, irritation, and relief (across all presentation blocks).

114 r eyebrow, eyelash, nail appearance, and eye irritation, and Scalp Hair Assessment PRO).

115 ty, the presence or absence of pain and skin irritation, and the changes in alignment observed over t

116 quality of life due to bleeding, pain, anal irritation, and tissue prolapse.

117 Photocopying was related to nasal irritation, and video display terminal work to eye sympt

118 f dye labeled PGN exhibited Fos-IR after LUT irritation; and a larger percentage (36%) exhibited Fos-

119 The corneal irritation appeared to drive an adaptive process organiz

120 hat differences in surfactant-induced ocular irritation are directly related to area and depth of acu

121 ors involved in the potential development of irritation are: inherent irritation potential of the age

122 which elicits the same restricted pharyngeal irritation as oleocanthal, also specifically excites rod

123 trusive, uncomfortable, and often cause skin irritations as they require a metal electrode affixed to

124 t (reporting daily glasses adherence without irritation) as judged by the patient, parent, or guardia

125 The slug mucosal irritation assay revealed that a low level of mucus was

126 aning conditions, potentially leading to the irritation associated with chlorinated bleach.

127 greater urinary incontinence and/or urinary irritation associated with these treatments compared wit

128 esigned device, standardized mechanical skin irritation at a force of 5 N was applied to the planta p

129 time point, investigators noted no signs of irritation at the application site in 885 patients who w

130 with mild adverse experiences, most commonly irritation at the injection site.

131 ent and included: cough, throat pain, throat irritation; at the highest dose with the formulation con

132 Anal irritation attributable to NOX66 occurred in 38%.

133 ceived either mechanical or chemical colonic irritation between postnatal days 8 and 21 and were test

134 Analogously, following acute colonic irritation, bladder contraction frequency increased 66%,

135 y group reported having long-lasting urinary irritation, bowel and sexual symptoms, and transient pro

136 Longitudinal sexual, incontinence, urinary irritation, bowel, and hormonal/vitality HRQOL were meas

137 e of the neurons recorded in rats with colon irritation, but had no effect on those in control rats.

138 mportant protective response to upper airway irritation, but the central mechanisms responsible for e

139 were removed and gingival mucosa scored for irritation by a previously described method.

140 thway raised the possibility that esophageal irritation by N-BPs is mechanism-based.

141 we report that action potentials or chemical irritation can elicit transient rises in [Ca2+]i (Ca2+ t

142 itation, in sharp contrast to the overt skin irritation caused by intradermal injections.

143 The corneal irritation caused by reduced blink amplitude generated a

144 ne treatment was associated with significant irritation, causing its discontinuation in one third of

145 We have previously shown that colon irritation (CI) in neonates results in chronic visceral

146 gen group reported extreme symptoms of nasal irritation compared with seven (6%) in the room air grou

147 ollow different patterns after chemical root irritation, compression, and a combined insult.

148 All symptoms (nose, eyes, and throat irritations; cough; bronchitis; cold; wheezing; asthma a

149 There was no tracheal irritation, coughing, or changes in spirometric measures

150 Ls were also examined for cytotoxicity, skin irritation, delivery of antibiotics through the skin, an

151 ent intermittent instillation site symptoms (irritation, discomfort) primarily on the initial lifiteg

152 n vitro studies of biocompatibility, mucosal irritation, disease, and other basic oral biology phenom

153 Following acute bladder irritation, dramatic increases in abdominal wall EMG act

154 Furthermore, ocular surface irritation during scrubbing was more common with TTO sha

155 Subjects reported significantly less eye irritation during the low-humidity exposure after using

156 can be modeled in rats by transient gastric irritation during the neonatal period, a time of known n

157 Dorzolamide did not reduce irritation elicited by pentanoic acid.

158 as safe for long-term use, and did not cause irritation even at high concentrations.

159 elf CSII catheters fully resolves early skin irritations, extends the longevity of catheters and impr

160 o CRD in control rats and in rats with colon irritation following stimulation or inactivation of the

161 rrent low-grade intraocular inflammation and irritation for months after implantation of the Ophtec 3

162 There was no mucosal irritation from the empty cups.

163 epiphora and 10% required removal because of irritation from the plugs.

164 ain the test drug in situ without extraneous irritation from the retention device.

165 Before bladder irritation, graded CRDs to 40 cm H2O produced no notable

166 information on respiratory, dermal, and eye irritation health.

167 creases in sexual, incontinence, and urinary irritation HRQOL.

168 ery presented with blurred vision and ocular irritation in both eyes for years.

169 eases such as liver diseases and respiratory irritation in humans.

170 Colon irritation in neonates, but not in adults, results in ch

171 injury as a mechanistic correlate to ocular irritation in the development and validation of potentia

172 These studies demonstrate that gastric irritation in the neonatal period can result in chronic

173 It is important to note that most irritation in the oral cavity tends to reverse quickly w

174 pressing Fos immunoreactivity (IR) after LUT irritation in the rat.

175 causing ocular surface inflammation and eye irritation in typical patients suffering from tear dysfu

176 Mechanical skin irritation in vascularized composite allotransplantation

177 hloride which induces ocular and respiratory irritations in swimming pool workers.

178 sociated extrinsic factors (i.e., mechanical irritation) in the oral mucosa.

179 accination with BCG-MNA caused no overt skin irritation, in marked contrast to intradermal vaccinatio

180 unity without incurring any appreciable skin irritation, in sharp contrast to the overt skin irritati

181 0.5% acetic acid into the bladder to produce irritation increased bladder activity and anal sphincter

182 Mechanical irritation, inflammation and other extracellular influen

183 after neonatal perturbation or acute colonic irritation/inflammation, current models of postinflammat

184 Oral irritation is a commonly occurring phenomenon.

185 nimals (n = 14) developed signs of meningeal irritation leading to death 30 to 63 days postinjection

186 Irritation leading to oral mucosal alterations is a comm

187 P < 0.05), whereas patients with symptoms of irritation, light sensitivity, and pain revealed a speci

188 ever, current topical products induce severe irritation, light-sensitivity, burning, scaling, and inf

189 R, 0.3; 95% CI, 0.1-0.9), history of vaginal irritation (LR, 0.2; 95% CI, 0.1-0.9), and vaginal disch

190 nd spatial distribution suggests that tissue irritation-mediated epithelial to mesenchymal transition

191 Through suppression of respiratory irritation, menthol may facilitate smoke inhalation and

192 absorbed across the nasal mucosa without the irritation mentioned above.

193 l explants and in vivo in the rabbit vaginal irritation model.

194 s, or those not requiring intervention, were irritation (n = 312) and subconjunctival hemorrhage (n =

195 and n = 1), hiccups (n = 4 and n = 1), mouth irritation (n = 4 and n = 0), difficulty sleeping (n = 3

196 y after RP, while bowel problems and urinary irritation/obstruction rose after EBRT and BT.

197 ary incontinence, 0.0 (-0.1,0.2) for urinary irritation/obstruction, -0.3 (-0.7,0.1) for sexual sympt

198 sory pathways can be upregulated by chemical irritation of afferent receptors in the urinary tract an

199 E" (as the method become known, to the great irritation of journal copyeditors and nomenclature commi

200 athophysiology of migraine involves not only irritation of meningeal perivascular pain fibers but als

201 We investigated the hypothesis that afferent irritation of one pelvic organ may adversely influence a

202 Since mechanical irritation of pulpal nociceptors is critical for evoking

203 Chemical irritation of the bladder of the rat increased the frequ

204 activation of afferent nerves after chemical irritation of the bladder.

205 e spinal cord induced by acetic acid (0.25%) irritation of the bladder.

206 Robust chemical or mechanical irritation of the colon of neonatal rats leads to chroni

207 tudy were to determine whether mild chemical irritation of the colon of neonatal rats produced persis

208 spinal cord of rats subjected to mustard oil irritation of the colon.

209 s in colon sensitivity after inflammation or irritation of the distal colon.

210 taining, increased inflammation, symptomatic irritation of the eyelid and globes, as well as decrease

211 tagonists may prevent and alleviate chemical irritation of the eyes, skin, and airways and reduce the

212 Chemical irritation of the lower urinary tract (LUT) induces c-fo

213 visceral nociception, specifically, chemical irritation of the lower urinary tract.

214 y to a supralevator perianal abscess causing irritation of the sciatic nerve, which was diagnosed on

215 e sciatic nerve, secondary to compression or irritation of the sciatic nerve.

216 hese sensations is that itch is initiated by irritation of the skin, whereas pain can be elicited fro

217 Minor irritation of the upper eyelids was noted at the 1-hour

218 noted in previous experiments after chemical irritation of the urinary bladder and urethra which acti

219 bladder pathways following acute and chronic irritation of the urinary tract of the rat.

220 olds to CRD and the effects of acute colonic irritation on micturition parameters were assessed.

221 ologies encounter challenges associated with irritation or discomfort caused by unwanted objects in d

222 n food consumption, with no evidence of skin irritation or discomfort.

223 und closure experiments; no visible signs of irritation or inflammation were observed.

224 harge, dysuria, genital pruritus, or genital irritation or odor.

225 ogical evaluation showed no evidence of skin irritation or other adverse effects of the treatments.

226 totic mechanism without any significant skin irritation or systemic absorption of NAVI.

227 ficacy in treating cancerous lesions without irritation or systemic absorption.

228 ), rash (OR = 1.32; 95% CI: 1.05, 1.66), eye irritation (OR = 1.25; 95% CI: 0.97, 1.62), and earache

229 al cavities and being perceived as pungency, irritation, or heat.

230 children experienced vomiting, acute rectal irritation, paradoxical hyperactivity, or prolonged seda

231 creased transepidermal water loss and caused irritation, particularly in AD patients carrying FLG mut

232 Here, we show that this rare irritation pattern is a consequence of both the specific

233 gible effect on skin integrity, nominal skin irritation potential and cytotoxicity.

234 diagnostic agents, but the skin toxicity and irritation potential of QDs are unknown.

235 tial development of irritation are: inherent irritation potential of the agent, amount of exposure (c

236 nation of transient compression and chemical irritation produces sustained bilateral hypersensitivity

237 ivitis sicca, filamentary keratitis, corneal irritation, punctate epithelial keratitis, and epithelia

238 a and frequency without vaginal discharge or irritation) raise the probability of UTI to more than 90

239 tion, the effects of acetaminophen on airway irritation reflex responses to ETS were examined by plet

240 O, and IPOH would not give rise to acute eye irritation-related symptoms in office workers; similarly

241 e to marine phytoplankton and reports of eye irritation, respiratory illness, and rash.

242 ffects of menthol on the respiratory sensory irritation response in mice elicited by smoke irritants

243 Irritation response of CPEs, on the other hand, correlat

244 olated cigarettes, immediately abolished the irritation response to acrolein, an agonist of TRPA1, as

245 AP-5, inhibited the pressor, tachycardic and irritation responses elicited by intrathecal (-)-epibati

246 The potential to cause human skin irritation responses is part of the required information

247 ific to acrolein, as menthol also attenuated irritation responses to acetic acid, and cyclohexanone,

248 ne exhibited selectivity for the pressor and irritation responses.

249 in control rats, whereas, in rats with colon irritation, responses either decreased or increased; sec

250 rosis factor-alpha may result from the local irritation seen with both oxazolone and phorbol ester.

251 fatty texture, dairy mouthfeel, and tingling/irritation" sensations.

252 Irritation severity in the desiccating environment was a

253 ymptom in the month prior (dryness, itching, irritation, soreness, or dyspareunia) and clinical atrop

254 continuously, and rated ocular sensations of irritation, stinging, burning, pricking, and cooling usi

255 Cytotoxicity and ocular irritation study demonstrated the safety of TM-implant c

256 to conduct, in dogs, a 6-hour acute mucosal irritation study of a new bioerodible treatment.

257 eatment are primarily local (ocular redness, irritation); surgical treatment carries a small risk for

258 neal staining, conjunctival staining, and an irritation symptom questionnaire (Ocular Surface Disease

259 l and conjunctival staining, blink rate, and irritation symptoms before and after each low-humidity e

260 Dryness and irritation symptoms, as opposed to a clinical diagnosis,

261 Eye irritation symptoms, blink rate, tear meniscus dimension

262 in oxidation products, linked to respiratory irritation symptoms, formed from the reaction between oz

263 a may be involved in the pathogenesis of the irritation symptoms, recurrent epithelial erosions, vasc

264 Eye irritation symptoms, tear meniscus height, tear break-up

265 s with normal aqueous tear production and no irritation symptoms.

266 bartenders (77%) initially reported sensory irritation symptoms.

267 nts and adverse respiratory, dermal, and eye irritation symptoms.

268 rneal sensitivity is associated with greater irritation, tear instability, ocular surface disease, an

269 g to people with skin of color, such as skin irritation, tenderness, itching, or skin becoming darker

270 The skin irritation test, performed on an in vitro reconstructed

271 ed by guine pig maximization and rabbit skin irritation tests.

272 and validation of potential in vitro ocular irritation tests.

273 an entirely new in vitro alternative to skin irritation tests.

274 l abnormalities, there may be a continuum of irritation that can be termed "irritant contact stomatit

275 speculate that plasticity in rats with colon irritation that may underlie chronic pain is sustained b

276 duced visual acuity, photophobia, and ocular irritation, though these symptoms typically resolve foll

277 Symptoms range from occasional redness and irritation to corneal ulcer.

278 urs following de novo chemical or mechanical irritation to ear skin and in spontaneously arising skin

279 be unsightly, spontaneously bleed, and cause irritation to patients.

280 rats sensitized with neonatal painful colon irritation to reveal the contribution of the thalamus an

281 stem can be activated by lower urinary tract irritation to suppress visceral nociception through cent

282 ty and permeability test demonstrated slight irritation to the cornea that resolved within 10 min.

283 outcomes (pain, hemodynamics stability, skin irritation, trunk kinematics) and secondary outcomes (ce

284 al general anesthetics (GAs) produce pain or irritation upon administration, and this occurs predomin

285 peripheral sensory nerves to cause pain and irritation upon administration.

286 -sexual dysfunction, urinary obstruction and irritation, urinary incontinence, and bowel problems-eac

287 While causing little skin irritation, vaccination efficacy of BCG-MNAs was compara

288 ved such symptoms include itching, sneezing, irritation, vasodilation, and reflex secretions.

289 to produce slight, mild, moderate, or severe irritation was applied to the central cornea of one eye;

290 sponses elicited by cGAMP with no overt skin irritation was attributable to its stay in the skin, whi

291 Evidence of local irritation was found at some SC injection sites.

292 parable to a clinically useful one, no local irritation was found with SC administration in rats.

293 patients whose baseline urinary obstruction/irritation was poor, both average scale scores and most

294 Overall, throat or mouth irritation was reported more frequently in the e-cigaret

295 nd a focal inflammatory reaction (mechanical irritation) was generated in the right flank.

296 Itch, the irritation we feel and the relief that comes from scratc

297 indicating that phagocytosis and nonspecific irritation were not responsible.

298 of vaginal discharge and history of vaginal irritation, which significantly decreased the likelihood

299 ; acute worsening of urinary obstruction and irritation with external beam radiotherapy (11.7 [95% CI

300 very time in barrier function following skin irritation, with a concomitant increase in EDC gene expr