ライフサイエンスコーパス: isoform

1 ChIP2 and another beta-subunit, DPP6-L (long isoform).

2 ing because of its similarity to the cardiac isoform.

3 emichannel contains the same or different Cx isoform.

4 k1/PEPCK-C) and mitochondrial (Pck2/PEPCK-M) isoform.

5 is, indicating Pck2 is the predominant PEPCK isoform.

6 he selectivity to monitor a single enzyme or isoform.

7 y depended on ZRANB2, SYF2 and the ECT2-Ex5+ isoform.

8 ssion of the DNA methyltransferase 1 (DNMT1) isoform.

9 sms of regulation or signaling of the longer isoform.

10 uced indicating that CTRL is a low-abundance isoform.

11 licing choice, with few cells producing both isoforms.

12 the cytosolic MPST1 and mitochondrial MPST2 isoforms.

13 ch of the variation between human transcript isoforms.

14 yzed for the presence of different molecular isoforms.

15 abundance of productive versus unproductive isoforms.

16 ciferase reporters using mouse and human FXR isoforms.

17 chiometries, even when only combining two Cx isoforms.

18 gh sequence homology across the class I PI3K isoforms.

19 ggesting differential roles for both calpain isoforms.

20 ts for functionally interrogating individual isoforms.

21 upregulating shortened TDP43 (sTDP43) splice isoforms.

22 xpressed stochastically, but rather as major isoforms.

23 riminate between structurally related enzyme isoforms.

24 ontaining 1,564 TF genes and 1,732 TF splice isoforms.

25 plishing the prediction of GO annotations of isoforms.

26 Asic1a and Asic2b were the dominant splice isoforms.

27 rophic growth based on different nitrogenase isoforms.

28 , shape and electrostatic parameters between isoforms.

29 that discriminate between the 11 human HDAC isoforms.

30 oncert with adenosine deaminase-like protein isoform 1 (ADAL1) to prevent incorporation of N6-methyl-

31 A novel partial agonist of the EPAC isoform 1 (EPAC1), I942, was recently discovered, but it

32 When treating CDKL5-mutant neurons, isoform 1 expression led to an increased density of syna

33 w that loss of the prolyl hydroxylase domain isoform 1 oxygen sensor in mice (PHD1(KO)) reduces muscl

34 Cdkl5 knockout male mice treated with isoform 1 via intrajugular injection at age 28-30 days e

35 JNK2, but not JNK1 (c-Jun N-terminal kinase isoform 1), increased SERCA2 uptake and consequently ele

36 Pyruvate kinase muscle isoform 2 (PKM2) is a key glycolytic enzyme and transcri

37 increased density of synaptic puncta, while isoform 2 ameliorated the calcium signalling defect comp

38 Human isoform 2 GFAT (hGFAT2) has been implicated in diabetes

39 hese activities also occurred with a CYP24A1 isoform 2 lacking the catalytic cysteine (Cys-462), sugg

40 in myocytes and HEK-RyR2 (ryanodine receptor isoform 2-expressing human embryonic kidney 293 cells) c

41 C cells revealed an increase in p120-catenin isoform 3A; similarly, depletion of APC altered the p120

42 growth factor beta (TGF-beta), NADPH oxidase isoform 4 (Nox4), caspase-3 and Bax.

43 Cleaved CDCP1 isoform (70 kDa) was expressed to a varying degree in al

44 Accurate estimation of transcript isoform abundance is critical for downstream transcripto

45 ants highlight the importance of the KS-WNK1 isoform abundance on potassium homeostasis.

46 gene expression and adaptive changes in Rca isoform abundance.

47 These truncated isoforms accumulated in the cytoplasm and formed insolub

48 cripts, we provide support for 23,865 splice isoforms across 14,611 genes, without the need for compu

49 NA-binding protein LIN-28 coordinates LIN-29 isoform activity, in part by regulating both hbl-1 and l

50 AKT has three isoforms, AKT1/AKT2/AKT3, with brain cell type-specific

51 ents HGP, knockdown of either TET3 or the P2 isoform alone in the liver improves glucose homeostasis

52 tion is whether the myosin heavy chain (MHC) isoforms alone account for these distinct physiological

53 Depletion of neither Rab6A or Rab6A' isoforms alone had any effect on anterograde transport t

54 and its catalytic alpha subunit exists in 2 isoforms: AMPKalpha1 and AMPKalpha2.

55 We present FLAIR (Full-Length Alternative Isoform analysis of RNA), a computational workflow to id

56 al splicing event analysis, and differential isoform analysis.

57 thophysiological relevance of the LAPTM4B-24 isoform and identify it as a dynamically regulated effec

58 investigated PDE4A, PDE4B, PDE4C, and PDE4D isoforms and found evidence associating them with severa

59 fferentially expressed DNA methyltransferase isoforms and had increased levels of IL-6 signaling inte

60 rnative splicing, producing multiple protein isoforms and mis-splicing has been implicated in disease

61 system for characterizing alternative myosin isoforms and modeling muscle diseases, but high-resoluti

62 translational modifications of the two PA2G4 isoforms and relate these to the functional cellular rol

63 approach to compare different peroxiredoxin isoforms and to identify mutations and small molecules a

64 s of which are made of three-repeat (3R) tau isoforms) and from Alzheimer's disease and chronic traum

65 s (antisense transcripts, alternative splice isoforms, and regulatory intergenic transcripts).

66 er mammals uncovered that long and short RPT isoforms are conserved among members of this phylogeneti

67 Here we report that multiple MYO7A isoforms are expressed in the mouse cochlea.

68 ncephalopathy (CTE) (in which both 3R and 4R isoforms are found in the filaments)(16).

69 bottleneck is that functional annotations of isoforms are generally unavailable and functional genomi

70 Our results also suggest that different isoforms are likely to be responsible for some of the va

71 ction and consequently their distinct 3' UTR isoforms are more likely to have functional consequences

72 in-2 and arrestin-3 and found that these two isoforms are regulated differently.

73 oforms, it is unclear how the C-terminal p63 isoforms are regulated.

74 ional knockout mice in which brain AMPKalpha isoforms are selectively suppressed (AMPKalpha1/alpha2 c

75 Taken together, Rsc1/2 isoforms are specialized through composition and interac

76 combinant fibrils assembled from all six Tau isoforms as well as Sarkosyl-resistant Tau aggregates ex

77 eq), a method to demarcate the boundaries of isoforms based on short-read sequencing, with higher eff

78 at, within a duplicated preprotein pair, the isoform bearing the leucoplast motif usually has greater

79 ellular backgrounds used, recruitment showed isoform bias toward arrestin 3 versus arrestin 2.

80 The globular domains of all three H1 isoforms bound to the nucleosome dyad.

81 y coincided with activation of the calpain-2 isoform but not with calpain-1, suggesting differential

82 temperature optimum of the most abundant Rca isoform by 5 degrees C in vitro, while maintaining the e

83 The relationships between MHC isoforms, calpain systems and meat quality characteristi

84 monstrate that isomeric carbohydrates of any isoforms can be distinguished and quantified using solel

85 hts how diverse roles of alternative protein isoforms can contribute to unique aspects of brain devel

86 significant up-regulation of oncogenic CD44 isoforms (CD44v) and increased CRC cell growth that was

87 ch encourages the development of methods for isoform-centered functional analysis.

88 We find that different models of isoform choice meaningfully change our simulation result

89 Therefore, we examined single Akt isoform, conditional brain-specific Akt1, and double Akt

90 pecific depletion approach showed that BMP2K isoforms constitute a BMP2K-L/S regulatory system that c

91 Multiple UNC-89 isoforms contain two protein kinase domains.

92 tive disorders, it is not clear which SynGAP isoforms contribute to disease.

93 results indicate that various CaMKK and AMPK isoforms contribute to infection in unique ways.

94 y, SGD has incorporated published transcript isoform data in our instance of JBrowse, a genome visual

95 were hormone dependent in addition to being isoform dependent.

96 n contrast, ApoE in solution demonstrated an isoform-dependent inhibition of hemolysis and complement

97 espiratory protein that exists as one of two isoforms depending on oxygen levels.

98 s coding for transcription factors increases isoform detection by an order of magnitude when compared

99 The protein expression of HLA isoforms did not significantly differ between breast can

100 The two isoforms differ substantially in their expression profil

101 Correspondingly, the two isoforms differentially affected lineage decision toward

102 tive probes with a focus on the relevance of isoform differentiation, design strategies to achieve se

103 y half the normal levels of the giant UNC-89 isoforms, dis-organization of pharyngeal muscle, small b

104 In vivo oncogenic Ras exists in isoform-distinct nanoclusters.

105 en together, our study reveals an unexpected isoform diversity of MYO7A expression in the cochlea and

106 improving our understanding of gene content, isoform diversity, and repeat organization.

107 iversity, namely, differential expression of isoforms due to alternative splicing, while the second m

108 n cancer suggests dynamic regulation of this isoform during cancer progression and metastasis.

109 anslationally repressed and derepressed mRNA isoforms during neocortical neurogenesis whose orthologs

110 strating seroconversion against different L1 isoforms during the natural course of papillomavirus inf

111 to define complete portfolios of full-length isoforms encoded by individual genes.

112 BC, however the precise functions of the ERK isoforms (ERK1 and ERK2) in cancer progression have not

113 3q26) results in overexpression of the MECOM isoform EVI1 and monoallelic expression of GATA2 from th

114 Here, we demonstrate that SynGAP isoforms exhibit unique spatiotemporal expression patter

115 is the primary voltage-gated sodium channel isoform expressed in mature axon initial segments and no

116 ationships driving selectivity for the Hsp90 isoforms expressed by Cryptococcus neoformans and Candid

117 ion of the CTD of SREBP2, one of three SREBP isoforms expressed in mammals.

118 In this study, ALDH isoform expression diversity was revealed in CICs with d

119 ariance score (AVS), a measure of tumor ALDH isoform expression diversity, compared to HPV-/p53HRmut

120 We demonstrate that unique isoform expression patterns are generated by the activit

121 predictive value of HLA-G and HLA-F protein isoform expression patterns in patients with breast canc

122 specialization is a consequence of distinct isoform expression patterns, not protein sequence, and w

123 Differential tau isoforms, expression levels, promoters, and disruption o

124 gest that Dnmt3b3 and perhaps similar Dnmt3b isoforms facilitate de novo DNA methylation during embry

125 Although the shorter isoform (FFA4-S) has been studied more extensively, very

126 Our results demonstrate that all Tau isoform fibrils exhibit paired-helical-filament-like str

127 onsistently produces either one or the other isoform for a particular splicing choice, with few cells

128 lex despite p110delta being the primary PI3K isoform found within monocytes.

129 ethod to detect the expression levels of APA isoforms from 3'-end RNA-Seq data by exploiting both pai

130 opment and stress response, how specific DGK isoforms function in development and phospholipid metabo

131 Whereas the autocatalytic activation of isoform gamma (AtLEGgamma) is controlled by the latency-

132 Humans express two types of GA isoforms: GLS and GLS2.

133 ng proportions of the slowly aggregating tau isoform gradually lowers the concentration of the isofor

134 3 are typically attributed to one of its two isoforms, GSK3beta, simply because of its prevalent expr

135 ammatory diseases and overexpression of a C4 isoform has recently been linked to schizophrenia, a C4

136 tioxidant (enzymes, including heme oxygenase isoforms [HO-1, HO-2]) markers.

137 by exploiting both paired-end reads for gene isoform identification and quantification.

138 tutions unique to the indirect flight muscle isoform (IFI) suggest that differences in the identity o

139 Human carbonic anhydrase (CA; EC 4.2.1.1) isoforms II and VII are implicated in neuronal excitatio

140 hat brain-specific suppression of AMPKalpha2 isoform impairs cognition and hippocampal LTP by PERK-me

141 most active and selective inhibitors against isoforms implicated in glaucoma were assessed in a rabbi

142 conclude, as Pck2/PEPCK-M is the predominant isoform in C2C12 cells, we postulate that 3-MPA promoted

143 by expressing the dominant-negative ETS1 p27 isoform in cord blood hematopoietic progenitor cells, we

144 role for an aberrantly expressed RBFOX2(40) isoform in DM1 cardiac pathogenesis.

145 Knockdown of the dominant ALDH isoform in high AVS HNSCC depleted the CIC pool in vitro

146 and underline the critical role of the FHF2A isoform in regulating Na(v) channel function.

147 mice, confirming a novel role of PLD2 as the isoform in RvD5-mediated resolution processes.

148 XO70A2 (At5g52340) is the main exocyst EXO70 isoform in the male gametophyte, governing the conventio

149 at considers how combinatorial expression of isoforms in a particular cell type, tissue or organism c

150 over a pathogenic role for alternative TDP43 isoforms in ALS, and implicate sTDP43 as a key contribut

151 r details of the functions of specific talin isoforms in cell adhesion.

152 E3 ubiquitin ligase with three known protein isoforms in humans.

153 Our data support roles for heme oxygenase isoforms in modulating recovery from synaptic injury in

154 We determined genome-wide binding of FXR isoforms in mouse liver organoids that express individua

155 es showed complete loss of large supervillin isoforms in muscle fibres by western blot and immunohist

156 ontrol, implying distinct functions of these isoforms in neurons.

157 iological importance of the more abundant CA isoforms in photosynthesis, through their effects on CO(

158 state transitions and the more diverse LHCII isoforms in the alga.

159 For the principal isoforms in the brain, CaMKII-alpha, with a ~30 residue

160 show the upregulation of two main human tau isoforms in the enteric nervous system (ENS) in CD but n

161 ed human carbonic anhydrase (hCA) IX and XII isoforms in the nanomolar range, while no affinity was e

162 rsus tumor-suppressive functions of two BRD4 isoforms in the regulation of gene expression and breast

163 individual kinetic steps of human myosin-1C isoforms in their productive interaction with nucleotide

164 To determine the roles of Akt isoforms in this model we crossed Akt1(-/-), Akt2(-/-),

165 xploits the antagonism between beta-arrestin isoforms; in low ligand conditions, PX favored beta-arre

166 with translated ORFs on multiple transcript isoforms, including targets of RNA surveillance mechanis

167 he N terminus of SIRT6 but absent from other isoforms, induced a conformational change that resulted

168 revious studies have suggested that the AKT2 isoform is critical for insulin-regulated glucose metabo

169 a negative regulatory function for this PLD isoform is proposed.

170 Pharmacological control of myosin isoforms is a promising approach to address metastatic d

171 The aspect of multiple protein isoforms is also considered in the selection tree, an as

172 MicroRNA isoforms (isomiRs) are distinct variations of miRNA sequ

173 xpression from unannotated loci and microRNA isoforms (isomiRs).

174 o differentially regulate the N-terminal p63 isoforms, it is unclear how the C-terminal p63 isoforms

175 es with maternal second trimester tocopherol isoform levels.

176 The LIM kinase isoforms LIMK1 and LIMK2 (LIMK1/2) play important roles

177 key residue difference between these myosin isoforms, located in the communication center of the fun

178 The full-length isoform, MR1A, can activate MAIT cells, while the functi

179 tivate MAIT cells, while the function of the isoforms, MR1B and MR1C, are incompletely understood.

180 observed that LPS potently stimulated GFAT2 isoform mRNA and protein expression.

181 The voltage-gated sodium channel isoform Na(V)1.7 is highly expressed in dorsal root gang

182 d selectivity over off-target sodium channel isoforms, Na(V)1.1-1.6 and Na(V)1.8.

183 Gene annotations, different transcript isoforms, nucleotide sequences and protein information,

184 (+) interneurons: Cox6a2, which codes for an isoform of a cytochrome c oxidase subunit.

185 riboswitch that selectively binds the trans isoform of a stiff-stilbene (amino-tSS)-a rapidly and re

186 vel, transcriptionally independent truncated isoform of ACE2, which we designate as deltaACE2 (dACE2)

187 Experiments have indicated that the beta isoform of CaMKII controls the bidirectional inversion o

188 tagmin (E-Syt) family, E-Syt1, and the short isoform of E-Syt2 (E-Syt2S), contribute to activation of

189 Mechanistically, E-Syt2S, the predominant isoform of E-Syt2 in T cells, recruited STIM1 to the jun

190 s variants in the N-terminal domain of the A isoform of FHF2 (FHF2A).

191 sistance by activating expression of the p41 isoform of invariant chain CD74, which inhibits viral en

192 of the eight mutations present in the 'Dd2' isoform of PfCRT (PfCRTDd2) enables the protein to trans

193 also report, in this study, that PKCbeta, an isoform of PKC, is required for both Src and Pyk2 activa

194 We previously documented that the Ca(V)3.3 isoform of T-type calcium channels (T-channels) is inhib

195 The immunoproteasome (iCP) is an isoform of the 20S proteasome that is expressed when cel

196 An unexplained paradox is how the beta isoform of the calcineurin catalytic A-subunit (CaNAbeta

197 isk gene CACNA1C, which encodes the Ca(v)1.2 isoform of the L-type calcium channel, have been implica

198 The large isoform of the transmembrane protein angiomotin (AMOT130

199 s rescued by the expression of the cytosolic isoform of yeast CAE, even though it was not imported in

200 ws a differential expression pattern for two isoforms of 36 and 33 kDa.

201 Many genes encoding isoforms of AGPase, soluble starch synthase, and other s

202 a mouse model with primate-lineage-specific isoforms of C4, human C4A and/or C4B.

203 thermore, we observed several phosphorylated isoforms of CHT7 under these conditions.

204 lucocorticoid-inducible kinase, and specific isoforms of DAF-16/FOXO transcription factor to regulate

205 cribe the crystal structures of two distinct isoforms of ligand-free human karyopherin RanBP5 and inv

206 esculenta) identified and characterized five isoforms of Manihot esculenta ADP-glucose pyrophosphoryl

207 Furthermore, we describe two isoforms of NOC in the mouse liver.

208 Two isoforms of SCAR/WAVE, WAVE1 and WAVE2, reside at the le

209 Filaments made up of different isoforms of tau protein are associated with a variety of

210 kroach allergen Cr-PI/Per a 3 in ACR and two isoforms of the allergen Api m 1 (phospholipase A2: PLA2

211 such factors, we used AAV vectors to express isoforms of the antiinflammatory cytokine transforming g

212 , we show that dynamic interplay between two isoforms of the Prickle protein determines right- or lef

213 cytokinin-induced protein synthesis requires isoforms of the ribosomal protein L4 encoded by the cyto

214 potent selective oral inhibitor of all three isoforms of the serine/threonine kinase AKT.

215 y differentiates the functions of respective isoforms of these two genes.

216 Two different isoforms of this protein, N-acetyltransferase 1 (NAT1) a

217 mixtures, often detecting several transcript isoforms of unknown functions for one gene.

218 CEBPB-liver-enriched activator protein (LAP) isoform overexpression suppresses MYO18B transcription b

219 erent genes, with an average of 5.22 protein isoforms per gene.

220 nuclear relocalization of pyruvate kinase M2 isoform (PKM2), a key regulator of the Warburg effect.

221 us work suggests that protein kinase C (PKC) isoforms play a role in cardiac fibrosis and remodeling,

222 tion of APC altered the p120-catenin protein isoform profile.

223 Simplex mRNA Sequencing (RNA-Seq) based isoform quantification approaches are facing the challen

224 y did not consider the impact of dropouts or isoform quantification errors, potentially confounding t

225 which we explicitly account for dropouts and isoform quantification errors.

226 d small GTPase, consists of 2 equally common isoforms, Rab6A and Rab6A', that differ in 3 amino acids

227 To assess the importance of the PGR isoform ratio in the maintenance of the reproductive tra

228 ells correlated with a decrease of the 36/33 isoform ratio.

229 VN to IO synapses contain fast synaptotagmin isoforms, release neurotransmitter synchronously, and ar

230 ucose metabolism, while the role of the AKT1 isoform remains less clear.

231 rm, the biological role of the intracellular isoforms remains largely unclear.

232 ning 197 bp DNA and three different human H1 isoforms, respectively.

233 encing (VIGS) to show that MeAPL3 is the key isoform responsible for starch and dry matter accumulati

234 cytosolic sulfotransferase 1A3 (SULT1A3)-the isoform responsible for sulfonating ~80% of the serotoni

235 ucidate the likely metabolic pathway and CYP isoforms responsible for DHD1 and DHD3 production and ch

236 ns that cause frameshifts in muscle-specific isoforms result in congenital multi-minicore myopathy.

237 ds that modulate the skeletal muscle channel isoform (RyR1) interaction with calmodulin and FK506 bin

238 e present study examined whether a novel PKC isoform(s) is involved in activating TRPC1-based SOCs in

239 isingly, global deletion of either, or both, isoform(s) was without significant effect on either the

240 HDAC (Vorinostat), class-selective (VPA) and isoform-selective (CAY10398, Romidepsin, PCI34051) HDAC

241 in human PH and the therapeutic potential of isoform-selective enzyme modulation are lacking.

242 Isoform-selective HDAC inhibition is a viable approach t

243 In the design of high-affinity and enzyme isoform-selective inhibitors, we applied an approach of

244 pecific small interfering RNA knockdowns and isoform-selective PI3K inhibitors identified PI3K-delta

245 ew highlights key examples of small-molecule isoform-selective probes with a focus on the relevance o

246 potent PI3Kgamma inhibitors that attain high isoform selectivity through the divergent projection of

247 ses both challenges for targeted full-length isoform sequencing applications using collections of clo

248 rther investigated the effects of brain- and isoform-specific AMPKalpha repression on AD pathophysiol

249 Isoform-specific differences include 18-fold changes in

250 of CME; however, detailed studies regarding isoform-specific early regulatory functions of the dynam

251 (AMPKalpha1/alpha2 cKO), and determined the isoform-specific effects in mice of either sex on cognit

252 sed of three unique homologous proteins with isoform-specific effects, but isoform-specific in vivo d

253 pluripotent stem cells (hiPSCs), indicating isoform-specific function.

254 Consequently, the importance of isoform-specific functions of GSK3 in synaptic plasticit

255 proteins with isoform-specific effects, but isoform-specific in vivo data are limited in follicular

256 To this end, we have constructed isoform-specific inhibitors of the human cytosolic sulfo

257 the regulation of hiPSC transcription in an isoform-specific manner, providing the basis for further

258 NAbeta compartmentation in cells based on an isoform-specific mechanism for calcineurin protein-prote

259 tudy reveals S-palmitoylation as a potential isoform-specific mechanism to modulate Nav activity and

260 crodomains promotes oxidative stress and Nox isoform-specific redox signalling important in vascular

261 Isoform-specific small interfering RNA knockdowns and is

262 n in culture, simultaneous knockdown of both isoforms strongly reduced the invasive motility of conti

263 regulatory programs leading to p120-catenin isoform switching and associated changes in cell-cell ad

264 nalysis comprehensively characterized splice isoform switching during the transition between mesenchy

265 on cell-cell adhesion genes and p120-catenin isoform switching in SW480 colon cancer cells: fl-APC in

266 ther starch synthases, SS5 is a noncanonical isoform that lacks catalytic glycosyltransferase activit

267 entified ERICH3 mRNA transcripts and protein isoforms that are highly expressed in central nervous sy

268 e first exons which produce multiple protein isoforms that differ in their N-terminal sequence.

269 The IGF1/Igf1 gene encodes multiple protein isoforms that differ in tissue expression, potency, and

270 CV genes produce large numbers of transcript isoforms that vary in their start and termination sites.

271 well-characterized function of the secreted isoform, the biological role of the intracellular isofor

272 se are small molecules that target the HIF-2 isoform through binding the PAS-B domain of HIF-2alpha.

273 PN1 is a key regulator of the C-terminal p63 isoforms through APA in coding sequence and mRNA transla

274 predict the association between GO terms and isoforms, thus accomplishing the prediction of GO annota

275 of the mammalian topoisomerase II (topo II) isoforms, topo II alpha and topo IIbeta.

276 istinct structural features of the two PA2G4 isoforms translate into different functional outcomes.

277 the relative contribution of different PI3K isoforms under homeostatic and inflammatory conditions.

278 liver organoids that express individual FXR isoforms using chromatin immunoprecipitation, followed b

279 noids and HepG2 cells that expressed the FXR isoforms using chromatin immunoprecipitation, quantitati

280 FXR1 isoforms vary in the formation of RNA-dependent biomolec

281 sis regulator, especially the earliest-known isoform, VEGF-A(165a).

282 A particular VGLUT isoform, VGLUT3, exhibits an overlapping, but unique, di

283 Neither T-type VGCC isoform was required for ACh-induced inhibition of contr

284 selective inhibition of the MAO-A and MAO-B isoforms was confirmed ex vivo in mouse brain homogenate

285 ctivities of mitochondrial-type CK and CK-MM isoforms were also lower (P<0.02, all analyses).

286 Here, we found that all NHE isoforms were expressed in wild-type (WT) mouse cochlea.

287 More than 38 500 novel transcript isoforms were identified, including six categories of fu

288 gical and nanomechanical properties of these isoforms were studied using atomic force microscopy at h

289 shootin1b) and a short (SHTN1S or shootin1a) isoform, which both contain the described PRR and WH2 do

290 This results in a complex range of isoforms whose biological relevance largely remains to b

291 results in production of an alternative mRNA isoform with a truncated 3' untranslated region.

292 rm gradually lowers the concentration of the isoform with high aggregation propensity, reducing the r

293 Mesotrypsin is an unusual human trypsin isoform with inhibitor resistance and the ability to deg

294 We also found that three fru isoforms with different DNA binding domains show a divis

295 F binding and expression of Ca(V)2.2 channel isoforms with increased opioid sensitivity in mice.

296 n be tuned by varying the relative levels of isoforms with long and short linkers.

297 transcriptome complexity by generating mRNA isoforms with varying 3' UTR lengths.

298 by nonsense-mediated decay (NMD) of splicing isoforms, with autism phenotypes usually triggered by re

299 re proven to be active as inhibitors of PDE1 isoforms, with IC(50) values in the high nanomolar/low m

300 f particular cancer types and particular Ras isoforms within these datasets.