ライフサイエンスコーパス: isogenic

1 xpression profiles of a previously generated isogenic 22Rv1 prostate cancer model of radioresistance

2 ic combinations shows similar affinities for isogenic alleles at 22 degrees C, but very poor interact

3 h we find can be targeted therapeutically in isogenic and primary DIPG cell lines with H3.3K27M mutat

4 otypically stable, are innately immortal and isogenic, and can be derived in an array of differentiat

5 enotypic plasticity, it is often essentially isogenic, and it has well-documented molecular and cellu

6 ound that individuals within strains are not isogenic, and there are differences in the levels of gen

7 in vitro and in vivo, within both engineered isogenic astrocytes and primary patient-derived model sy

8 , PMN recruitment to wounds infected with an isogenic AT-deficient S. aureus strain was unimpeded, ex

9 moter affect lifespan when expressed in a co-isogenic background.

10 roresistance, in which seemingly susceptible isogenic bacterial populations contain resistant sub-pop

11 eciation of gene expression heterogeneity in isogenic bacterial populations, affordable and scalable

12 We performed isogenic bone marrow transplantation of inducible sphing

13 gene 1 ( BRCA1)-deficient cells compared to isogenic BRCA1-proficient cells.

14 ace proteins is dramatically remodeled in an isogenic breast epithelial cell line stably expressing a

15 enerated a gradient in tension over multiple isogenic budding yeast cell lines by genetically alterin

16 nts (epiHybrids), which we derived from near-isogenic but epigenetically divergent parents.

17 in MA high/low drinking mice, as well as in isogenic C57BL/6J mice that varied in their MA preferenc

18 uently infected with cag (+) H. pylori or an isogenic cagE (-) mutant (nonfunctional T4SS).

19 tivity of TFs associated to mutant PIK3CA in isogenic cancer cell line models.

20 sis-defective and -resistant cancer cells or isogenic cancer cells, via calcium mobilization through

21 ype, we compared the protein profiles of two isogenic canine OS cell lines, POS (low metastatic) and

22 served significantly reduced survival of the isogenic carrier mutant compared to that of the parental

23 Elimination of pilus production in the isogenic carrier mutant decreased its ability to coloniz

24 Elimination of pilus in the isogenic carrier mutant increased the level of survival

25 ivity against colon cancer cell lines and an isogenic cell line pair reporting on the status of APC-d

26 ure for oncogenic KRAS derived from a murine isogenic cell line with a coexpression network derived b

27 ly no methods for the discrimination between isogenic cell lines (cell lines of the same genetic orig

28 Using isogenic cell lines and patient-derived samples, we show

29 V5-FOXL2(WT)- and V5-FOXL2(C134W)-inducible isogenic cell lines and performed chromatin immunoprecip

30 We used isogenic cell lines and primary patient materials to dis

31 Using isogenic cell lines and xenografts, the authors show tha

32 Using isogenic cell lines producing high and low levels of NSD

33 Here, we employ a set of isogenic cell lines that express different Akt isoforms,

34 r survival of more than 300 kinase-deficient isogenic cell lines to a diverse panel of DNA-damaging a

35 backgrounds, we screened two pairs of BRCA2 isogenic cell lines with DNA-repair-focused small hairpi

36 Isogenic cell lines with endogenous alpha1 and inducible

37 ring of the identity of cell lines including isogenic cell lines.

38 utations using stably transfected, inducible isogenic cell lines.

39 .76-0.99) when using chromogenic staining in isogenic cell lines.

40 in vivo studies of differentially methylated isogenic cell lines.

41 oratory routine and 2) the authentication of isogenic cell lines.

42 CR) genotyping technology to create scarless isogenic cell models of cancer variants in 1 month.

43 In this study we have created isogenic cell panels (MDA-MB-231 and MCF-7) expressing f

44 igm of adaptive resistance development in an isogenic cell population.

45 How phenotypically distinct states in isogenic cell populations appear and stably co-exist rem

46 s bind only to the latter, we tested whether isogenic cell populations respond in a non-uniform manne

47 An isogenic cell system indicated that E6 largely accounts

48 significant phenotypic differentiation among isogenic cells frequently occurs, with the resulting het

49 Isogenic cells have different lengths of the early inter

50 We applied the method for obtaining isogenic cells homozygous for variant B cystatin C, a re

51 synthase genes, suggesting that some of the isogenic cells in a population might produce autoinducer

52 The authors demonstrate that the majority of isogenic cells in bacterial populations survive lethal a

53 tion of the expression level of a gene among isogenic cells in the same environment, and has two sour

54 ysico-chemical principles that determine how isogenic cells spontaneously self-organize into structur

55 We used CRISPR/Cas9-genome editing to create isogenic cellular models.

56 by the resident inhibited colonization by an isogenic challenger.

57 Here, generating tetraploid isogenic clones in colorectal cancer and in non-transfor

58 NAs isolated from intracellular DSM20231 and isogenic clpC mutant cells identified alterations in tra

59 An isogenic codY-null mutant of SM101 showed decreased leve

60 /eod1-2 mutants were already larger than the isogenic Col-0 wild type, but this phenotype was trigger

61 r, we used precise gene targeting to produce isogenic colon cancer cell lines with a knockout/rescue

62 ches with hiPSC-based models permits precise isogenic comparisons of human neurons and glia.

63 based genome engineering facilitates precise isogenic comparisons of variants across genetic backgrou

64 her generated a lon-1 deletion mutant and an isogenic complemented strain.

65 establishing OFCD study models by generating isogenic control BCOR-WT iPSCs versus BCOR-mut iPSCs.

66 9+/-29 ms; n=10) compared with the patient's isogenic control hiPSC-CMs (434+/-30 ms; n=8; P<0.05).

67 ficantly longer (622+/-11 ms; n=92) than the isogenic control hiPSC-CMs (453+/-5 ms; n=62; P<0.0001).

68 CACNA1C-p.R518C hiPSC-CMs when compared with isogenic control hiPSC-CMs.

69 ived RAF1(S257L/+) and CRISPR-Cas9-generated isogenic control inducible pluripotent stem cell (iPSC)-

70 is activated in mutant iPSC-CMs compared to isogenic control iPSC-CMs.

71 r cefotaxime was 3-fold higher than for near-isogenic control isolates, consistent with a first step

72 r cefotaxime was 3-fold higher than for near-isogenic control isolates, consistent with a first-step

73 romium (Cr) and nickel (Ni) exposure than an isogenic control line.

74 different methods have been used to generate isogenic control lines using clustered regularly intersp

75 Using patient-specific hiPSC-CM mutant and isogenic control lines, we demonstrate that the CACNA1C-

76 press a long-acting analogue of GLP-1 or the isogenic control microbe which solely harbored the pNZ44

77 ic p.Gly23Val-MRAS variant in patient cells (isogenic control) and to introduce the pathogenic varian

78 on and characterization of patient-specific, isogenic control, and disease modeled induced pluripoten

79 -specific efflux pump (TetA) compared to the isogenic control.

80 erentially expressed genes compared with its isogenic control.

81 n neuritic length and complexity relative to isogenic controls as well as contorted axons with Tau-po

82 milial AD mutations vs. their wild-type (WT) isogenic controls in order to characterize the aberrant

83 or the SNCA-A53T mutation contrasted against isogenic controls, we evaluated the consequences of alph

84 By comparing patient-derived MNs and their isogenic controls, we show that ALS-causing mutations in

85 ipotent stem cell (iPSC)-derived neurons and isogenic controls, we show that the FTD-causing V337M ta

86 M model combined with CRISPR/Cas9-engineered isogenic controls, we uncovered that TnT-R173W destabili

87 e dysfunction in HCM iPSC-CMs as compared to isogenic controls.

88 h optical mapping and compared them to their isogenic controls.

89 ger neurons compared with those derived from isogenic controls.

90 ase in arrhythmic calcium traces compared to isogenic controls.

91 reased insoluble alpha-synuclein relative to isogenic controls.

92 Importantly, isogenic conversion of APOE4 to APOE3 attenuates the APO

93 The isogenic correction of the C9orf72 HRE restored normal g

94 Here we use primary H3K27M tumor lines and isogenic CRISPR-edited controls to assess H3K27M effects

95 on, we profile microglia differentiated from isogenic, CRISPR-modified TREM2-knockout induced pluripo

96 erived optic vesicles (OVs) when compared to isogenic cultures of hiPSC-derived forebrain neurosphere

97 tion generates a mosaic of methylomes within isogenic cultures, which we formalize as 'intercellular

98 Low-cost scalability of isogenic, custom-length cssDNA is demonstrated for a seq

99 We produced isogenic deletion mutants for every S. epidermidis psm l

100 ep neural layers of the ischemic retina than isogenic diabetic vascular progenitors (DVP).

101 in Arabidopsis thaliana tetraploid lines and isogenic diploids, we show that transcriptome abundance

102 otent stem cell (hPSC) platform, in which 30 isogenic disease lines are pooled in a single dish and d

103 DLC1-positive cancer cell line but not in an isogenic DLC1-negative cell line.

104 colon cancer; the prodrug did not inhibit an isogenic DLD-1 tumor with wild-type BRCA2.

105 The derived isogenic dorsal cortical (higher expression of TBR1 and

106 atin interactions, we established stable and isogenic Drosophila epilines that carry alternative epia

107 Here we used a panel of 32 isogenic Drosophila simulans lines to test for genetic v

108 lonoids infected with EAEC, but not with its isogenic EAECpic mutant.

109 s above those observed during challenge with isogenic empty vector controls.

110 effects of mutant ER, we developed multiple isogenic ER-mutant cell lines for the most common LBD mu

111 are genome-wide methylation patterns between isogenic ESC and EGC lines to define epigenetic similari

112 ardiomyocytes, and compared with healthy and isogenic (established by CRISPR/Cas9-based mutation corr

113 n factors in developing mouse ES-DCs with an isogenic expression screen.

114 se FANCD2-dependent mechanisms, we generated isogenic FANCI-, FANCD2- and FANCI:FANCD2 double-null ce

115 ts in the linear sorting of a set of diverse isogenic female lines, unambiguously demonstrating the h

116 tomachs from mice infected with a mixture of isogenic, fluorescent H. pylori strains with unprecedent

117 t the transcriptome and proteome profiles of isogenic FMRP-deficient neurons demonstrate perturbation

118 immature spike tissues in three lines nearly isogenic for Q revealed over 3000 differentially express

119 ins, Diversity Outbred (DO) stock, and their isogenic founder strains.

120 Using isogenic GBM cell lines with endogenous EGFRvIII express

121 resenilin-1 or amyloid precursor protein vs. isogenic gene corrected controls.

122 We used an isogenic germline knock-in mouse model to study the effe

123 We developed isogenic GIST lines in which the parental forms were KIT

124 Here we report that ATRX loss in isogenic glioma model systems induces replication stress

125 nstructed and characterized a large panel of isogenic H. pylori strains that differ primarily in the

126 Using an isogenic HCT116 colon cancer model of oxaliplatin resist

127 Furthermore, an isogenic HDC-deficient L. reuteri mutant that was unable

128 Our experiments in isogenic HEK293 cells reveal that YAP can affect cell si

129 cosylation pathways to generate a library of isogenic HEK293 cells with combinatorially engineered gl

130 An isogenic hiPSC-CM gene-corrected control was created usi

131 Characterization of isogenic hiPSC-derived neurons using heterochromatin and

132 Humanized mice were infected with isogenic HIV molecular clones (HIV-WT, HIV-45G, and HIV-

133 However, studies using HK2 shRNA and isogenic HK1(+)HK2(-) and HK1(+)HK2(+) tumor cell pairs

134 since expression of lngA was up-regulated in isogenic hns and crp mutants.

135 dsRNA) bacteriophage phi6 (wild type and two isogenic host range mutants) on the novel host Pseudomon

136 region that was not polymorphic for the two isogenic host range mutants.

137 ed a low level of protection against ZIKV in isogenic human astrocytes.

138 rmed transcriptome and proteome profiling in isogenic human colon organoids.

139 ent that, we used genome editing to generate isogenic human embryonic stem cells (hESCs) harboring cl

140 Here we have used CRISPR/Cas9 to generate isogenic human embryonic stem cells (hESCs) that lack th

141 Here, we establish isogenic human ESC-derived microglia-like cell lines (hM

142 vance to both PROS and cancer, we engineered isogenic human induced pluripotent stem cells (iPSCs) wi

143 Here, we apply a genetic approach, using isogenic human induced pluripotent stem cells, to evalua

144 ants during cardiomyocyte differentiation of isogenic human induced pluripotent stem cells.

145 We used CRISPR-Cas9 to generate isogenic human leukemia cell lines of the most common TP

146 es and neuronal properties in the context of isogenic human neurons remains lacking.

147 ce indels in exon 3 of FMR1, we generated an isogenic human pluripotent stem cell model of FXS that s

148 Using isogenic human pluripotent stem cells as a model to inve

149 nistic role of SNCA in the nucleus utilizing isogenic human-induced pluripotent stem cells-derived ne

150 In vitro studies of patient-derived and isogenic human-pluripotent-stem-cell-derived cardio-myoc

151 into oxidized chromatin we have established 'isogenic' human diploid cells in which PARP1 and/or PARP

152 Using isogenic Huntington's disease human embryonic stem cells

153 his study supports the clinical relevance of isogenic in vitro models of radioresistance and clarifie

154 geneity) leads to phenotypic diversity among isogenic individual cells.

155 Many traits vary among isogenic individuals in homogeneous environments.

156 Using isogenic induced pluripotent stem cell (iPSC) lines carr

157 Cultures of isogenic induced pluripotent stem cell (iPSC) lines with

158 with MYBPC3 PTC mutations by utilizing human isogenic induced pluripotent stem cell-derived cardiomyo

159 enesis of SNCA in these cells, generating an isogenic iPSC line with normalized SNCA gene dosage.

160 "scarless" gene-editing methods, we created isogenic iPSC lines that differ only in the length of th

161 301L mutation and generated P301L:Deltap35KI isogenic iPSC lines using CRISPR/Cas9 genome editing.

162 Isogenic iPSC lines were generated from HCM patients har

163 but the protein levels were comparable among isogenic iPSC-CMs, suggesting that haploinsufficiency of

164 and weaker polygenic risk variants to ASD, 'isogenic' iPSC-derived neurons are critical.

165 We created cerebral organoids from the isogenic iPSCs and found that blockade of p25 generation

166 found that differentiated cells derived from isogenic iPSCs and nt-ESCs showed comparable lineage gen

167 Having used this pair of isogenic iPSCs to define this phenotype, these cells can

168 We utilised isogenic keratinocytes, microvascular endothelial cells,

169 editing technologies to generate a panel of isogenic knockin human iPSC lines carrying APP and/or PS

170 Using whole genome sequencing of an isogenic knockout cell line panel, we find a universal H

171 sembly mechanism of the TCR complex in human isogenic knockout cells.

172 An isogenic knockout mutant of the open reading frame NTHI1

173 Investigating single, double and triple isogenic knockout mutants of the PhiHKU.vir-encoded exot

174 Cured mice rejected the growth of isogenic KRAS(G12D) tumours, which suggests adaptive imm

175 ficantly improved nor worsened compared with isogenic L. monocytogenes-primed control mice.

176 By exploiting a near-isogenic line population derived from a cross between th

177 odifications were examined in a pair of near isogenic lines (NILs) (with and without Lr28 in the back

178 Near-isogenic lines (NILs) can be used to characterize, disse

179 We grew four near isogenic lines (NILs) for the Eps gene located in chromo

180 Here, we developed and used a pair of near-isogenic lines (NILs) to characterize DNA methylome land

181 We used genetic mapping and near isogenic lines (NILs) to identify, validate and fine-map

182 We created near isogenic lines and assayed the phenotype in multiple env

183 larvae and adults of Drosophila melanogaster isogenic lines derived from a natural population to extr

184 is gene introgressed in desi and kabuli near-isogenic lines enhances the seed weight, yield, producti

185 Using near-isogenic lines generated from the introgression of the C

186 es were also tested for virulence to 20 near-isogenic lines that differ for leaf rust resistance gene

187 s9) homology directed repair (HDR) to create isogenic lines that varied for the F187Y substitution.

188 nd apoptosis-and performed RNA sequencing on isogenic lines to identify differentially expressed gene

189 ungal leaf microbiomes of the resulting near-isogenic lines were compared with the microbiome of the

190 Using near-isogenic lines, and strains with CRISPR-Cas9 mediated de

191 KRAS G12V overexpression in an isogenic lung model reveals >50,600 DM CpGs compared to

192 We generated isogenic MCF10A cell lines with deletion mutations of ge

193 on in individual patients, we differentiated isogenic MDS induced pluripotent stem cells harboring up

194 ific organoids from hiPSCs incorporated with isogenic microglia-like cells in order to enhance immune

195 r approach will facilitate tissue atlases of isogenic model organisms or from multiple biopsies or lo

196 We generated tumor-derived isogenic models bearing this mutation and show that it l

197 rbation dataset on PI3K and MAPK pathways in isogenic models of a colon cancer cell line, it generate

198 Here, we have generated a stable and isogenic motor neuronal NSC34 cell model with inducible

199 ed to identify and characterize subgroups of isogenic mouse offspring exposed to identical MIA, which

200 s have been largely carried out using inbred isogenic mouse strains, in which there is no (or very li

201 ls as well as a complementary strategy using isogenic murine embryonic stem cells with monoallelic K7

202 th a wild-type B anthracis strain or with an isogenic mutant deficient for the protective antigen.

203 An isogenic mutant deficient in hcp is not able to grow wit

204 consumption specific to RTT patient-derived isogenic mutant NPCs was observed, though the pattern of

205 Thus, isogenic mutant stains of S. aureus with varying degree

206 ingipain activity is higher in 33277, and an isogenic mutant strain deficient for the gingipains exhi

207 encoding 5 transporters confirmed that each isogenic mutant strain was significantly (P < 0.05) impa

208 Targeted gene deletion confirmed that isogenic mutant strains DeltaspyAD and Deltaisp2 are sig

209 e trait loci analysis, machine learning, and isogenic mutant strains identified and confirmed a one-n

210 Here, isogenic mutant strains lacking EmaA structures, but sti

211 Isogenic mutant strains of S. aureus with varying degree

212 ficile strains but not with a TcdA(-)TcdB(-) isogenic mutant.

213 Using isogenic mutants and recombinant expression of Lha, we d

214 However, the two isogenic mutants had dramatically restricted neighborhoo

215 We found that isogenic mutants lacking SPN, SLO, and both toxins are e

216 Using isogenic mutants of C. difficile strain NAPI/BI/027 defi

217 A screen of isogenic mutants revealed that the highly surface-expres

218 on studies of L. monocytogenes wild type and isogenic mutants together with biochemical studies with

219 ve strain 7.13, as well as various bacterial isogenic mutants were employed.

220 nd different S. pyogenes serotypes and their isogenic mutants, reveals how changing microenvironments

221 pathway to internalization was confirmed by isogenic mutants.

222 lope perturbations that were reversed in the isogenic mutation-corrected cells.

223 ated in two sets of independently engineered isogenic N40D iNs.

224 ere we examined the trophoblast potential of isogenic naive and primed hPSCs.

225 e sublancin produced at high levels by their isogenic neighbors.

226 plication of CRISPR technologies to engineer isogenic neural cells to study the impact of common vari

227 sing a murine model of periodontitis and two isogenic non-capsulated mutants of P. gingivalis, this s

228 ith the encapsulated W50 wild-type strain or isogenic non-encapsulated DeltaPG0116-PG0120 (GPA) and D

229 N2-fixing symbionts progressively outcompete isogenic non-fixers within root nodules, where N2-fixati

230 e we demonstrate, with the use of motile and isogenic nonmotile deletion mutants of two independent s

231 ough primary DIPG tumor characterization and isogenic oncohistone expression, we show that the same H

232 From 95 isogenic P. aeruginosa mutant, an hmgA mutant generated

233 Isogenic P1 deletion mutants were used to reconstitute t

234 An isogenic pair of cell lines are transduced with a lentiv

235 e-wide loss-of-function genetic screen in an isogenic pair of human colorectal cancer cell lines harb

236 ofile double-strand break repair pathways in isogenic paired cell lines, we demonstrate that the HPV1

237 Isogenic pairs of cell lines, which differ by a single g

238 Here, we present an approach to create isogenic pairs of cells that avoids single cell cloning,

239 By using an isogenic panel of cell lines derived from MDA-MB-231 bre

240 We compared across an isogenic panel of human breast cancer cells derived from

241 and a lower bacillithiol redox ratio vs. the isogenic parent, indicating a higher level of oxidative

242 of COMT was found in dopaminergic neurons of isogenic PARK2 induced pluripotent stem cell lines that

243 olonic epithelium by Wild-type EAEC than its isogenic Pic mutant.

244 that was absent from organoids injected with isogenic pks-mutant bacteria.

245 Using an isogenic pluripotent stem cell model derived from patien

246 nhances noise in mRNA distribution across an isogenic population of cells.

247 d phenotypic variability within an otherwise isogenic population of cells.

248 This allows an isogenic population to break the trade-off between repro

249 pation of cytomorphological states within an isogenic population.

250 ant phenotype by individual cells even in an isogenic population.

251 Isogenic populations of cells exhibit phenotypic variabi

252 n addition, a fraction of individuals within isogenic populations raised in controlled environments h

253 We show that within isogenic populations, all cells become naturally compete

254 r their antigenic variation in comparison to isogenic preselected populations.

255 G cell line to study ddC-induced toxicity in isogenic proliferating (undifferentiated) and nonprolife

256 e approach, we visualized DNA replication in isogenic PSCs generated by different reprogramming appro

257 We used isogenic radiation-resistant and -sensitive A549 human l

258 We generated isogenic RB1 mutant genotypes with CRISPR/Cas9 in a numb

259 Here, we employed RSA59 (an isogenic recombinant strain of MHV-A59)-induced experime

260 pool decoding, we created a large library of isogenic reporter clones and identified reporter integra

261 der Rett syndrome, with exosomes released by isogenic rescue control neural cultures.

262 solates with rocA polymorphisms (n = 48), an isogenic rocA deletion mutant strain, and five isogenic

263 ogenic rocA deletion mutant strain, and five isogenic rocA polymorphism mutant strains to perform gen

264 n silent subtelomeric chromatin in otherwise isogenic Saccharomyces cerevisiae.

265 ique, treatment induced mutations in sets of isogenic samples with very low false positive rates.

266 Using 30 isogenic samples, reliable cohorts of validated mutation

267 experimentally induced mutations in multiple isogenic samples.

268 PSC-derived central nervous system (CNS) and isogenic sensory neurons.

269 n, we used Zinc finger nucleases to generate isogenic SHANK3 knockout human embryonic stem (ES) cell

270 usly inoculated mice were challenged with an isogenic SpA-deficient S. aureus mutant, cells prolifera

271 visualize the clinical isolate PMSS1 and an isogenic straight-rod mutant (Deltacsd6) within thick lo

272 ype T. thermophilus outcompetes an otherwise isogenic strain lacking TtAgo.

273 ed a high fat/sugar water-induced animal (an isogenic strain of C57BL/6 J:129S1/SvImJ mice) model of

274 not with a polysaccharide A (PSA) deficient isogenic strain.

275 Previous data generated using non-isogenic strains and transfection models suggest that va

276 Infection studies with isogenic strains having defined toxin deletions have est

277 omatin organization and transcription, using isogenic strains lacking all combinations of these enzym

278 atory strains carrying pMB2 grew faster than isogenic strains lacking the plasmid in both rich and mi

279 uronal viral retrograde tract tracing, using isogenic strains of pseudorabies virus (PRV) with distin

280 comparison between CpMV1-free and -infected isogenic strains revealed no overt effects of the virus.

281 Fluorescent protein-based differentiation of isogenic strains revealed that priority of gut colonizat

282 We used isogenic strains to test the hypothesis that a single am

283 unctions-within the population of individual isogenic strains, along single misshaped cells, and even

284 inhibited by HGA secreted from neighboring, isogenic strains.

285 nd gene expression analysis between a nearly-isogenic Sw-7 line and its susceptible recurrent parent

286 Using a novel panel of isogenic SW48 cell lines endogenously expressing wild-ty

287 ining native or recombined symbionts against isogenic symbiont-free hosts showed that the fitness ben

288 Over the last ten years, isogenic tagging (IT) has revolutionised the study of ba

289 ion in RYR1 exon 36 (p.Gln1970fsX16) that is isogenic to that identified in one parent of a severely

290 nt B. anthracis Ames wild-type strain or the isogenic toxin-deficient mutants DeltaEF, DeltaLF, and D

291 was confirmed by competition experiments in isogenic TP53-WT and TP53-null (TP53(-/-)) cell lines.

292 0(4) colony-forming units of wild-type or an isogenic typhoid toxin deletion mutant (TN) of S. Typhi.

293 molecule screen based on competition between isogenic untransformed cells and BCR-Abl-transformed cel

294 y observed in culture, providing potentially isogenic virus-free lines enabling studies probing the b

295 Flour from near-isogenic wheat lines differing in PIN haplotype and lipa

296 nergetics and mitochondrial function between isogenic wild-type and mutant neural progenitor cell (NP

297 to most of the tested compounds than does an isogenic wild-type strain.

298 In our conditions, for isogenic wild-type worms, the health decline of the indi

299 Q1970fsX16+A4329D RYR1 mutations, which are isogenic with those identified in a severely affected ch

300 by studying the dynamics of the response of isogenic yeast populations to a shift in carbon source,