ライフサイエンスコーパス: isograft

1 recipients (allografts) or the same strain (isografts).

2 enal subcapsular transplantation of an islet isograft.

3 10 (50%) of 20 PRKO mice without a pituitary isograft.

4 polymorphonuclear leukocyte influx into the isograft.

5 otec on the individual tissues of a rat limb isograft.

6 n in allografts and no signs of rejection in isografts.

7 y use human tumor xenografts or murine tumor isografts.

8 were significantly decreased in transplanted isografts.

9 ng growth factor-beta in these cold-ischemic isografts.

10 re tested for their ability to reject second isografts.

11 ifferences between control and cold ischemic isografts.

12 M-1 and cytokines comparable to that seen in isografts.

13 own in both transfected COS7 cells and heart isografts.

14 infiltration was greater in allografts than isografts.

15 Group 4 rats (n=3) received isografts.

16 cies; (4) DMBA alone; and (5) DMBA+pituitary isografts.

17 n in isografts, but IL-4 was detected in 3/5 isografts.

18 mpared with acutely rejecting allografts and isografts.

19 t bm12 allografts appeared no different than isografts.

20 titate the intensity of antibody staining in isografts.

21 ee in the immediately adjacent myocardium in isografts.

22 ion after 18-h culture than cells from liver isografts.

23 challenge, allografts, or without challenge, isografts.

24 l as in intimal thickness when compared with isografts.

25 EIIIB+ FN ratios remain relatively low in isografts.

26 nhance nerve regeneration in the same way as isografts.

27 irway lumen, changes not seen in heterotopic isografts.

28 ected into the rNG and the resident cells of isografts.

29 nation therapy was comparable to that of the isografts.

30 DBA/2 kidneys or B6.Foxp3(DTR) recipients of isografts.

31 the HSP response in treated versus untreated isografts.

32 in the cellular infiltrates around the islet isografts.

33 e majority of the few remaining monocytes in isografts.

34 sively in allografts but only transiently in isografts.

35 ative pathway of complement, in IRI to heart isografts.

36 Bcl-2 protein limits I/R injury in rat lung isografts.

37 y expressed in allografts when compared with isografts.

38 were examined in small-bowel allografts and isografts.

39 d and interleukin-6 (IL-6)-treated steatotic isografts.

40 response between the parental tumor and its isografts.

41 shown to influence primary function of islet isografts.

42 ynthase (iNOS) protein in allografts but not isografts.

43 thelial cells, and only IP-10 was induced by isografting.

44 eNG, rNG, and normal isografts (15 mm long) were implanted in the peroneal ne

45 4 with a ninefold increase as compared with isografts (24.0+/-3.7% vs. 2.7+/-0.5; P<0.05).

46 ontinuous hormone stimulation with pituitary isografts; (3) multiple pregnancies; (4) DMBA alone; and

47 antly higher hydroxyproline content than the isografts (33.21 +/- 1.89 versus 22.36 +/- 2.33 mug/mL).

48 ercentage of luminal occlusion compared with isografts (47% compared with 1.2%).

49 8+/-0.46 ml/min/kg) compared to nonrejecting isografts (7.98+/-1.62 ml/min/kg; P<0.01), but significa

50 c cells in DBA/2-->DBA/2 heterotopic cardiac isografts, acutely rejecting DBA/2-->C57BL/6 cardiac all

51 e intense nonimmune inflammation produced in isografts after donor BD may represent the initial stage

52 of 566+/-19, 76+/-22, and 504+/-105 mmHg for isograft, allograft, and aminoguanidine-treated allograf

53 Compared with airway isografts, allografts exhibited a significant increase i

54 ed native kidney; and Gp 4, those bearing an isograft and a sham-clipped native kidney.

55 terally nephrectomized LEW recipients as the isograft and allograft control, respectively.

56 Isograft and allograft controls received no treatment.

57 ted in normal eyes, remained unchanged among isograft and allograft groups.

58 Isograft and further allograft recipients were killed, a

59 controls--F-344 rats received an F-344 renal isograft and low-dose CsA; (3) experimental group--F-344

60 Isografts and 42.9% of allografts achieved normal clinic

61 Isografts and allografts (Fisher 344 rats-->LEW) from 45

62 , transient MIP-2 and MCP-1/JE production in isografts and allografts correlated with neutrophil and

63 ent, early MIP-2, and MCP-1/JE production in isografts and allografts correlated with neutrophil and

64 Vascular lesions of aortic isografts and allografts were evaluated quantitatively w

65 g-term effects of this risk factor on kidney isografts and allografts were examined with a rat model.

66 erence in HSP levels in cyclosporine-treated isografts and allografts.

67 anism of early PMN infiltration into cardiac isografts and allografts.

68 subcutaneous implantation of murine tracheal isografts and allografts.

69 as expressed at equivalent levels in C57BL/6 isografts and bm1 and bm12 allografts.

70 ina, muscle, kidney, and uvea) compared with isografts and controls.

71 ombined immunodeficient disease (SCID) islet isografts and delayed the rejection of allogeneic C57BL/

72 ED1+ cells were rare in isografts and did not stain for HO.

73 urvival following IRI in both Lewis-to-Lewis isografts and Fischer-to-Lewis allografts.

74 hanges were markedly less pronounced in Gp 3 isografts and minimal in the kidneys of the normotensive

75 Lewis isografts and normal Fischer-344 kidneys served as contr

76 2 and g = 1.94 (for Fe-S cluster protein) in isografts and normal hearts.

77 or functions of leukocytes in allografts and isografts and provide a foundation for testing their fun

78 into FN increases by day 1 in allografts and isografts and remains high until allografts are rejected

79 Lewis renal isografts and uninephrectomized rats that did not underg

80 .05 pmol L-citrulline.mg protein-1.min-1 for isografts) and was significantly reduced with dexamethas

81 ary blood flow ratio, the weight gain of the isograft, and the scores for histological categories of

82 issue from tolerant, acutely rejecting (AR), isografted, and naive animals using nonisotopic in situ

83 an Th2 cytokines in allografts compared with isografts, and both Th1 and Th2 cytokine gene expression

84 and 9 (45%) of 20 PRKO mice with a pituitary isograft; and (b) 10 (50%) of 20 WT mice and 10 (50%) of

85 14), cyclosporine-treated (10 mg/kg SQ/day) isografted animals (n = 12), and cyclosporine-treated al

86 raft and a sham-clipped native kidney; Gp 3, isografted animals with a clipped native kidney; and Gp

87 no histologic evidence of acute rejection in isografted animals.

88 entum of Lewis (allografts) or Brown Norway (isografts) animals.

89 ed tracheas obliterated completely, although isografts appeared patent with normal respiratory epithe

90 an additional group of mice receiving renal isografts as controls.

91 een in untreated allografts as compared with isografts as determined by PhosphorImage analysis.

92 control specimens and syngeneic transplants (isografts) as control specimens for the alloimmune respo

93 CS-1+ FNs increase in allografts and isografts at 3 hours after transplantation but are parti

94 ificantly greater than that of the untreated isografts at all time points.

95 in C57BL/6 allogeneic skin grafts and BALB/c isografts at day 2 posttransplant.

96 or each) in the allografts compared with the isografts at Weeks 2 through 6.

97 had received allografts; three had received isografts) at 7 T.

98 Isografts (BALB/c into BALB/c) and allografts (BALB/c in

99 Isografts (BALB/c into BALB/c) and allografts (BALB/c in

100 ly twofold longer survival in an orthotopic, isograft breast cancer mouse model.

101 ssion was negligible in nonrejecting cardiac isografts but was significantly enhanced in rejecting al

102 ansplant, chemokine mRNA levels decreased in isografts but were maintained at high levels in the allo

103 No IL-10 was seen in isografts, but IL-4 was detected in 3/5 isografts.

104 bitor, prevents primary nonfunction of islet isografts by reducing inflammatory reactions at the graf

105 onged cold ischemia can initiate mild GAD in isografts by transiently enhancing antigen non-specific

106 , and epithelial cell replacement in denuded isografts can significantly reduce the fibrotic progress

107 y of murine heterotopic vascularized cardiac isografts caused a small, albeit significant, increase i

108 Relative to control isografts, cold ischemia induced transiently enhanced en

109 response to xenografts is sufficient to kill isografts complicates issues of immunoprotection, sugges

110 In contrast, isografts continued to beat beyond 90 days.

111 The isograft control was performed from LBN-F1 into LBN-F1.

112 (standard uptake value allograft, 2.8+/-0.3; isograft control, 1.7+/-0.2; P<0.05).

113 e untreated allograft in comparison with the isograft control, of which 77 genes were categorized as

114 All isograft controls (Lewis to Lewis, n=6) survived unevent

115 As references, we used 55-day isograft controls (n=5) and native hearts (n=6).

116 ls demonstrated severe parenchymal fibrosis; isograft controls and intrathymic (IT) animals failed to

117 e in allograft controls and were absent from isograft controls and IT allografts as determined by rev

118 sed to approximately 50% of that observed in isograft controls by POD4.

119 grafts with chronic vasculopathy compared to isograft controls on day 28 (P = 0.01).

120 Isograft controls survived indefinitely.

121 Isograft controls survived indefinitely; in allografts w

122 In allograft recipients and isograft controls, NF-kappaB was assayed by electrophore

123 10 days of low-dose cyclosporine (CsA); (2) isograft controls--F-344 rats received an F-344 renal is

124 nor hearts into C57BL/6 recipients served as isograft controls.

125 and 28 (4.8% vs 0.9%; P = 0.006) compared to isograft controls.

126 ays) but falls to normal levels in tolerated isografts (day 6).

127 Isografts demonstrated normal histology with minimal HO-

128 fter receiving a kidney allograft but not an isograft, despite the avoidance of antibiotics and immun

129 LEW and DA recipients of liver isografts developed no toxicity and survived indefinitel

130 Isografts did not display the late pattern of sustained

131 Rejecting allografts and isografts did not express intragraft IL-10.

132 Donor hearts and isografts did not express myocardial VSM alpha-actin, in

133 (1) Cardiac isografts display no detectable TUNEL+ cells.

134 6 pretreatment of steatotic Zucker rat liver isografts dramatically reduces mortality and liver injur

135 Isografts, eNG, and rNG all had similar patterns of pero

136 Treatment of islet isografts ex vivo with ad5-CMV-beta-galactosidase result

137 exhibited decreased ADC values (P <.01) and isografts exhibited similar ADC values compared with nat

138 nd active TGF-beta, whereas accepted cardiac isografts express only tPA, but not uPA or activated TGF

139 The isografts expressed more epidermal growth factor than al

140 Isograft expression of RANTES and IP-10 was undetectable

141 expressed at equivalent levels in allo- and isografts for 2-4 days posttransplant and then returned

142 METHODS AND We transplanted isografts from B6 mice and allografts from Balb/c mice h

143 r, and molecular changes occurring in kidney isografts from BD donors are compared with those from no

144 At 5 days, the isografts from BD donors were highly infiltrated by host

145 Changes in isografts from brain-dead donors were less marked and de

146 Arterial isografts from donor WT mice that had been anastamosed t

147 Groups included both allografts and isografts from normotensive brain dead donors and anesth

148 Histological examination of islet isografts from these rats showed complete destruction of

149 Bone marrow (BM) isografts from WKY to WKY or Lewis to Lewis did not affe

150 CCL2 inversely correlated (P < 0.0001) with isograft function.

151 Isografts generally showed no arterial changes.

152 Isograft glomerular filtration rate (GFR) was measured a

153 ses of 55% and 97% above the activity in the isografted group in hepatic uptake of annexin V on days

154 ation was detected between the xenograft and isograft groups.

155 e found that most normal tissues and cardiac isografts had minimal expression of PD-1, PD-L1, or PD-L

156 All isografts had normal function.

157 Mouse heterotopic isograft heart transplants were performed in C57BL/6 mic

158 f vimentin preimmunization on allogeneic and isografted hearts in a murine transplant model.

159 ll adhesion molecule-1 compared to normal or isografted hearts.

160 rafted (immunologically mismatched) and five isografted (immunologically matched) recipient rats on d

161 ET-1 levels increase after isograft implantation, and ET-1 plays a key role in CNI-

162 Utilizing small intestine isografts implanted into the subcutaneous tissue of adul

163 xenografts and allografts in comparison with isografts in diffusion chambers with 0.4-microm pore mem

164 rence of diabetes in renal subcapsular islet isografts in DR-BB (RT1uu) rats with established autoimm

165 , and the latter were indistinguishable from isografts in either WT or SCID recipients, indicating a

166 revented the recurrence of diabetes in islet isografts in rats with established autoimmune diabetes.

167 f in situ administration of this agent on FP isografts in rats.

168 for preservation-reperfusion injury of lung isografts in the rat.

169 factors was locally administered to eight FP isografts in the thigh muscle of diabetic rats.

170 Immunofluorescent staining of islet isografts infected with ad5-CMV-beta-galactosidase revea

171 Mononuclear cells recirculated to native and isografted intestine and recirculation was inhibited by

172 Isografted intestine developed normally; it was not expo

173 The kidneys were then isografted into genetically identical Lewis rats and GFR

174 When a vein fragment from TIE2-LacZ was isografted into the carotid artery of wild-type mice, th

175 e of vein segments donated by wild-type mice isografted into TIE2-LacZ mice at 1 week and reached con

176 ing heparan sulfate phenotype in control and isografted kidneys toward a FGF2-binding phenotype in al

177 There were 4 experimental groups: untreated isografted (LEW to LEW) animals (n = 14), untreated allo

178 at I-FABP was not detectable in the serum of isografted Lewis rats, but could be measured in the peri

179 idney to a Lewis rat; n = 17) and in control isografts (Lewis kidney to a Lewis rat; n = 17).

180 was performed in histocompatibility matched (isografts: Lewis --> Lewis) and mismatched (allografts:

181 Isografts maintained good oxygenation and perfusion thro

182 Kidney isografts (male Lewis rats [LEW]-->LEW) were transplante

183 In the absence of a pituitary isograft, mammary tumors developed in 4 (20%) of 20 WT m

184 ignificant vascular changes were observed in isografts (mean medial areas of 3.3 +/- 0.3x0(5) microm2

185 -dimethylbenz(a)anthracene (DMBA), pituitary-isografted mice, there was a marked reduction in mammary

186 bition of TLR2 promotes graft function in an isograft model of renal transplantation.

187 An isograft model was used to demonstrate that retrieval an

188 lung preservation and transplantation in an isograft model, and that inhibiting complement activatio

189 nfirming local complement activation in this isograft model.

190 mus (Tac) and sirolimus (Sir) in a rat renal isograft model.

191 ects of Ad-HO-1 gene transfer in a rat renal isograft model.

192 tumour progression in multiple subcutaneous isograft models and an autochthonous transgenic model of

193 Here, we established an arterial isograft mouse model in wild-type and endothelial RIPK1

194 an resting membrane potential of control and isograft muscle cells was -69 +/- 0.9 mV with a slow-wav

195 survival times of tobacco-treated animals), isografts (n=3), both donor and recipient rats exposed t

196 0 mg/kg per day by oral gavage, n = 10), and isograft negative control (Lewis-to-Lewis, n = 5).

197 DBA/2-->DBA/2 cardiac isografts never displayed TVS in this time period, but d

198 The isograft not only developed into a morphologically norma

199 Controls included allografts and isografts not treated with CsA.

200 In aortic isografts of apolipoprotein E-knockout mice treated with

201 Isografts of either PDK1- or PKCalpha-expressing cells b

202 In contrast, vascular changes in isografts of hypertensive hosts were restricted to media

203 rats were given an eNG on the right, and an isograft on the left.

204 ted signal in rejected allografts but not in isografts or MPO-deficient allograft recipients.

205 ry cytokine genes was not observed in either isografts or native heart.

206 eas no staining was detectable in WKY to WKY isografts or native lungs.

207 /c, H-2L(d+)) were transplanted into BALB/c (isografts), or single class I MHC-mismatched (L(d)-defic

208 d severe acute rejection, but not in normal, isograft, or allograft lungs before histological changes

209 erved in FK506-treated allograft recipients, isografts, or native intestine of allograft recipients.

210 s 3.2 +/- 0.5 versus 1.1 +/- 0.4 in diabetic isografts (P < 0.03) and zero TxCAD in nondiabetic allog

211 tor (A2AR) in WT allografts compared with WT isografts (p = 0.032), additional experiments were perfo

212 3 +/- 2% luminal occlusion vs. 17 +/- 1% for isografts, P < 0.05) with sites of obstructive lesion fo

213 levels (67 +/- 5 versus 18 +/- 2 microM for isografts; P < 0.001) that were significantly reduced by

214 In this study, we isografted PanO2 pancreatic carcinoma cells into mice in

215 PMN infiltration into isografts peaked at 9 to 12 hours post-transplant and qu

216 C3-/- kidney isografts placed in wild-type C3+/+ mice were protected

217 2 resulted in reduced PIP and increased lung isograft pulmonary vein PaO(2) compared with AdvNull or

218 Twenty-one allograft (PVG.1U-->PVG.R8) and 9 isograft (PVG.R8-->PVG.R8) transplantations were perform

219 al were superior to irradiated allograft and isograft rates of survival (P < 0.001).

220 Nonirradiated allograft and isograft rates of survival were superior to irradiated a

221 Isograft rats (n=5) and control allograft rats (n=4) rec

222 Early survival and renal dysfunction of isografted rats correlated with the interval of donor ca

223 ere associated with sutures in allograft and isograft recipients and within conjunctivae, either scat

224 immune rats were transferred to WKY rat lung isograft recipients followed by assessments of lung path

225 significantly higher than the BP of control isograft recipients.

226 more severe in bm1 and F1 allografts than in isografts recovered from B6 recipients, but bm12 allogra

227 ssion of these genes in nonrejecting cardiac isografts, rejecting cardiac allografts, and cardiac all

228 Isografts remained functional for >100 days, whereas all

229 ant models using wild-type animals, tracheal isografts remained open without rejection, whereas allog

230 Islet isografts removed from the rats showed low levels of ins

231 Isografts resisted LCMV-induced rejection, and the inter

232 Isograft retransplantation resulted in a similar inciden

233 Miller staining of the isografts revealed disruption of the basement membrane a

234 In a guinea pig-to-guinea pig (n=6) isograft series, biopsy controls for preservation/ischem

235 anted into C57BL/6 (B6, H-2b) recipients; B6 isografts served as controls.

236 Untreated Lewis to Lewis isografts served as histological controls.

237 In contrast, day-90 cardiac isografts showed little to no TVS development.

238 ACI isografts showed no evidence of CGVD (n=6) at day 90.

239 In isografts, stable luminescence intensity signals occurre

240 ibit alveologenesis in response to pituitary isograft stimulation; thus, DMBA-initiated mammary tumor

241 In addition, 90% of the rats receiving liver isografts stored in UW solution supplemented with PSGL-1

242 jection were absent in long-term transfected isografts, suggesting that long-term expression of activ

243 determine the effect of selectin blockade on isograft survival in a syngeneic rat orthotopic liver tr

244 ocumented by a significant increase in liver isograft survival.

245 Isografts survived >30 days regardless of OVA(323-339) a

246 Ifnb-/- mice with intracerebral isografts survived poorly.

247 0(-6)) were 2- to 10-fold higher compared to isografts throughout the time-course of graft injury.

248 ograft animals when compared with normal and isograft tissues.

249 nimals when compared with that in normal and isograft tissues.

250 ued by allowing embryonic Fiaf-/- intestinal isografts to develop in Fiaf+/+ recipients.

251 at transgene expression persisted in cardiac isografts transfected with an adenovirus encoding beta-g

252 After isograft transplantation, weight bearing began by day 17

253 ctional in vivo cross talk in the setting of isograft transplantation.

254 The composite hemiface isograft transplantations were performed in group 1.

255 s (blood glucose > 300 mg/dl) received 16 FP isografts transplanted intramuscularly.

256 Isograft transplants (Lewis to Lewis, +DM/+/-F) were con

257 Isograft transplants survived indefinitely.

258 ermore, growth of highly aggressive melanoma isograft tumors was suppressed by single agent treatment

259 ary gland grafts by inclusion of a pituitary isograft under the renal capsule as a source of prolacti

260 Mild GAD developed in isografts undergoing 4-hour cold ischemia.

261 and 50 days (group 3) and compared with F344 isografts undergoing retransplantation after 4 days (gro

262 opment of coronary lesions in retransplanted isografts underlines the participation of antigen-indepe

263 NA expression remains nearly constant in the isograft, unlike the normal intact small intestine.

264 Recipients underwent left nephrectomy and isografting using standard techniques.

265 ion by illuminating intraperitoneally placed isografts using a laparotomy.

266 XCL10 on the autoimmune destruction of islet isografts using RIP-LCMV mice expressing a lymphocytic c

267 gher protease activity in allografts than in isografts using tomographic fluorescence.

268 ed allograft serum nitrite/nitrate levels to isograft values.

269 severe atherosclerosis and vessel rupture in isografted vessels of apolipoprotein E-knockout mice occ

270 induces hepatoprotection of steatotic liver isografts via preventing sinusoidal endothelial cell nec

271 am operation was used as the control and the isograft was used as the benchmark procedure.

272 Expression of these genes in control isografts was at low levels, with the exception of JE, w

273 Class II expression in isografts was limited to epicardial macrophages.

274 Expression of IP-10 and Mig in isografts was low or undetectable.

275 immune destruction of CXCL10-deficient islet isografts was significantly reduced.

276 Using murine isografts, we attempted to prevent this islet graft dama

277 Small portions of the lung isograft were excised and stained with an antibody speci

278 By contrast, pituitary isografts were able to rescue the ductal elongation phen

279 Isografts were analyzed 48 hours after transplantation f

280 Lung isografts were analyzed using micro-positron emission to

281 inferior vena cava-to-carotid interposition isografts were completed using an anastomotic cuff techn

282 Rat trachea isografts were denuded of epithelium by protease digesti

283 Lung isografts were injured and platelets accumulated in the

284 Heterotopic brown Norway rat cardiac isografts were removed on postoperative day (POD) 3, 5,

285 Treated animals and isografts were sacrificed 120-130 days posttransplant fo

286 BALB/c allografts and C57BL/6 (B6) isografts were transplanted into B6 severe combined immu

287 Immunohistochemistry and murine intestinal isografts were used in which the small intestine from ne

288 sufficient to induce rejection pathology in isografts, whereas tolerance to col(V) suppresses allogr

289 necrapoptosis in steatotic Zucker rat liver isografts, which is prevented by in vitro IL-6 pretreatm

290 th WF cells, unlike lymphocytes from the LEW isografts, which produced Th1 cytokines when challenged

291 ograft without immunosuppression, n=7), III (isograft with immunosuppression, n=5), and IV (isograft

292 tion of the insulin-producing portion of the isograft with residual cells positive for glucagon.

293 Treatment of fetal pancreas (FP) isografts with insulin-like growth factor-I greatly impr

294 (4/9) allografts were indistinguishable from isografts with no evidence of rejection, and were consid

295 hormones, and virgin mice bearing pituitary isografts with persistently elevated hormones.

296 ografts showed inferior survival compared to isografts, with no difference in survival between the al

297 ograft with immunosuppression, n=5), and IV (isograft without immunosuppression, n=6) were included t

298 ntation after 4 days (group 4) and with F344 isografts without a second procedure (group 5).

299 37 +/- 9%, NS), whereas coronary arteries of isografts without a second transplant procedure (group 5

300 bronchiolar and perivascular inflammation in isograft (WKY) lungs and abrogated col(V)-induced oral t