ライフサイエンスコーパス: isoleucine

1 tein triacylglycerol (1)H NMR resonances and isoleucine.

2 ne resolution of isomers such as leucine and isoleucine.

3 ous iron (Fe) or the amino acids leucine and isoleucine.

4 of Lys to the total amount of Met, Thr, and isoleucine.

5 e base-binding pocket, with bulky leucine or isoleucine.

6 h an increase of jasmonic acid and jasmonoyl-isoleucine.

7 of one of these lysine residues, Lys-313, to isoleucine.

8 , propionate, glucose, tyrosine, proline and isoleucine.

9 cluding lipoproteins, glucose, creatine, and isoleucine.

10 l function is to aminoacylate tRNA(Ile) with isoleucine.

11 ed in intersubunit clashes among the mutated isoleucines.

12 1.44 (95% CI 1.26-1.65, p = 9.5 x 10-8) for isoleucine, 1.85 (95% CI 1.41-2.42, p = 7.3 x 10-6) for

13 P of pandemic A/BM/1/1918 (H1N1), comprising isoleucine-100, proline-283, and tyrosine-313, that is e

14 Compared with the control, isoleucine-10g reduced the blood glucose AUC and peak bl

15 Isoleucine-10g, but not isoleucine-5g, slowed gastric em

16 mics analyses showed higher levels of JA, JA-isoleucine, 12-oxo-phytodienoic acid, and arabidopsides

17 Furthermore, we identified isoleucine-182 in transmembrane domain 3 of zDHHC3 as a

18 mutation of alanine 145, histidine 180, and isoleucine 191 on 14-3-3sigma isoform promotes GluN2C bi

19 val for IFG based on a fully adjusted model: isoleucine 2.29 (1.31-4.01), leucine 1.80 (1.10-2.96), v

20 f novel conjugates of THC with alanine (2a), isoleucine (2b), proline (2c), valine (2d), phenylalanin

21 d (amino acid=L-valine (1), L-leucine (2), L-isoleucine (3), L-tryptophan (4), L-phenylalanine (5), L

22 A mutation of isoleucine 335 to valine (I355V) in hSLC2A9 can reduce f

23 he phosphatidylserine head group passes near isoleucine-364 (I364) and that I364 is critical to the r

24 human URAT1 serine-35, phenylalanine-365 and isoleucine-481 are necessary and sufficient to provide u

25 ltaF508) and a silent codon change (SCC) for isoleucine-507 (I507-ATC-->ATT).

26 +2 sequon position with PglB is modulated by isoleucine 572.

27 blood glucose (P < 0.01), whereas effects of isoleucine-5g were NS.

28 Isoleucine-10g, but not isoleucine-5g, slowed gastric emptying (P < 0.05), but g

29 We found that PA residue isoleucine 656 plays a critical role in PA binding to TE

30 lanine+tyrosine (32.6%), leucine (45.7%) and isoleucine (68%) are found less in haustorium.

31 The best peptide (IC50 =89 nm) replaces isoleucine 689 with an S-gamma-methyl stapled amino acid

32 adiolabeled antagonist ((125)I-sarcosine(1), isoleucine(8) Ang II) in brain homogenates and tissue se

33 Mutation of this isoleucine abrogated VP2 incorporation into virus-like p

34 ens triggers higher jasmonic acid, jasmonoyl-isoleucine accumulation, and jasmonic acid-dependent gen

35 differ; leucine stimulated insulin, whereas isoleucine acted insulin independently.

36 with glycoprotein acetyls, LDL-diameter and isoleucine - all reported biomarkers of CAD-risk, inflam

37 tes with amino acids glutamine, tyrosine and isoleucine, along with serum cholesterol measures and at

38 rminal epitope of neuropeptide glutamic acid-isoleucine/alpha-melanocyte-stimulating hormone (NEI/alp

39 Isoleucine, alpha1-acid glycoprotein, and glucose were l

40 s, involving hydrophobic contacts between an isoleucine and a conserved threonine in the selectivity

41 mine; binds through a 2-fork plug made of an isoleucine and a tyrosine residue at +3 and +8 positions

42 lucose, amino acids like histidine, leucine, isoleucine and alanine, and also 2,3-butanediol, methano

43 of GNAT toxins beyond the earlier described isoleucine and formyl methionine tRNAs, and suggest that

44 oc-protected alpha-amino diazoketones from L-isoleucine and L-threonine and to the preparation of a d

45 physical activity is associated lower serum isoleucine and leucine in peripubertal girls, independen

46 In addition, isoleucine and leucine levels increased significantly (

47 parts higher fidelity, but replacements with isoleucine and leucine resulted in lower-fidelity phenot

48 hesis of branched-chain amino acids (valine, isoleucine and leucine) were also absent, but genes for

49 esulted in the accumulation of jasmonic acid-isoleucine and loss of dormancy in seeds of stressed pla

50 length, glycoprotein acetyls, tyrosine, and isoleucine and lower levels of high-density lipoprotein

51 c acid, alanine, threonine and low levels of isoleucine and methionine.

52 te is produced, conjugated to the amino acid isoleucine and perceived by a co-receptor complex compos

53 that mimics the plant hormone jasmonic acid isoleucine and promotes opening of stomata for bacterial

54 ric acid, 4-hydroxyproline, glycine, leucine+isoleucine and putrescine proved to be useful for differ

55 VimA mediated coenzyme A (CoA) transfer to isoleucine and reduced branched-chain amino acid metabol

56 We found that isoleucine and S-adenosylmethionine bind to the ACT doma

57 roduction of jasmonic, (+)-7-iso-jasmonoyl-L-isoleucine and salicylic acid in certain parts of the ho

58 the WPH components tested, the amino acid L-isoleucine and the peptide L-leucyl-L-isoleucine showed

59 he branched chain amino acids (BCAs) leucine/isoleucine and their deaminated metabolites, and lowered

60 Lactobacilli produced leucine, isoleucine and valine as branched chain amino acids when

61 that were proline, hydroxyproline, leucine, isoleucine and valine on the negative side of PC1 and po

62 Branched-chain amino acids (BCAAs; leucine, isoleucine and valine) are elevated in the blood of obes

63 Branched chain amino acids (leucine, isoleucine and valine) were also present in substantial

64 d degradation (named for leucine, valine and isoleucine) and seed development was limited to leucine

65 l-leucine but also includes l-methionine, l-isoleucine, and l-valine.

66 id biosynthetic machinery utilizing glucose, isoleucine, and serine.

67 ed to the identification of N-malonyl-D-allo-isoleucine, and the discovery of a novel amino acid race

68 Proline, L-arginine, L-histidine, L-isoleucine, and tryptophan were accumulated in the leave

69 metacluster formation of serine, asparagine, isoleucine, and tryptophan.

70 branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are elevated in maple syrup urine

71 s of the branched-chain amino acids leucine, isoleucine, and valine in this acute study.

72 Only alanine, glutamate, isoleucine, and valine, but not leucine, were increased

73 hain amino acids (BCAAs), including leucine, isoleucine, and valine, has shown potential benefits for

74 supports queries where isobaric leucine and isoleucine are treated equivalent, and an option for sea

75 ly amino acids including methionine, lysine, isoleucine, arginine, and aromatics, tend to promote str

76 Infrequent residues (e.g. isoleucine, arginine, cysteine, proline, aspartate, and

77 ched-chain amino acids (valine, leucine, and isoleucine), aromatic amino acids (tryptophan and phenyl

78 nthesis of JA and the bioactive conjugate JA-isoleucine, as well as activation of the JA signaling pa

79 Five of these AAs (tyrosine, alanine, isoleucine, aspartate, and glutamate) were also found to

80 ting solely of leucines, except for a single isoleucine at a particular position, transformed cells.

81 R can result from substitution of valine for isoleucine at codon 122 of the transthyretin (TTR) gene

82 cture-based mechanism for mismatching of the isoleucine at position 181 and the increased vaccine eff

83 by serine at position 281 and methionine by isoleucine at position 309.

84 ly) or non-functional (AVI: alanine, valine, isoleucine at positions 49, 262, and 296, respectively)

85 lting in an amino acid change from valine to isoleucine at residue 19 of Nsp1beta diminished its abil

86 /H(+) antiporter, even though it contains an isoleucine at the Glu(in) position that was previously t

87 interesting deviation is the decoding of the isoleucine AUA codon as methionine by the one mitochondr

88 Consequently, deletion of ilvA causes isoleucine auxotrophy.

89 : 9.1% +/- 11%; low-BCAA: 12.0% +/- 13%), or isoleucine (BCAA: 2.5% +/- 11%; low-BCAA: 7.3% +/- 11%).

90 beta = -6.0, 95% CI [-9.5; -2.4], p = 0.001; isoleucine: beta = -5.2, 95% CI [-8.6; -1.8], p = 0.003;

91 a decrease in herbivory-induced jasmonoyl-l-isoleucine biosynthesis and expression of JA responsive

92 GA and MYC2 binding motifs, MYC2, and the JA-isoleucine biosynthesis enzymes DDE2/AOS and JAR1 are fu

93 he threonine dehydratase IlvA is part of the isoleucine biosynthesis pathway in the Gram-positive mod

94 e deaminases, we generated a strain in which isoleucine biosynthesis was interrupted at the level of

95 wth and specifically inhibits coenzyme A and isoleucine biosynthesis.

96 d competitively inhibits a key enzyme in the isoleucine biosynthetic pathway.

97 oteins consisting exclusively of leucine and isoleucine (called LIL traptamers) that specifically act

98 from a precursor metabolite generated in the isoleucine catabolic pathway.

99 moiety is derived from an intermediate of l-isoleucine catabolism.

100 An (l)-(+)-isoleucine chiral bisoxazoline ligand and the presence o

101 Translation of the isoleucine codon AUA in most prokaryotes requires a modi

102 epend on signaling via (1) the jasmonic acid-isoleucine conjugate (JA-Ile) and (2) other octadecanoid

103 production of the stress hormones jasmonate-isoleucine conjugate and abscisic acid, which represents

104 in GA3 or the functional analog of jasmonoyl-isoleucine, coronatine.

105 ransition pore (mPTP) opener, and N-methyl-4-isoleucine cyclosporine (NIM811), an mPTP inhibitor, wer

106 Asc-1 antiporter activity is enhanced by D-isoleucine (D-Ile), which releases D-serine and glycine

107 WPH components: (a) control; (b) WPH; (c) L-isoleucine; (d) L-leucine; (e) L-leucine plus L-isoleuci

108 ormal vs primary HGSOC; valine, leucine, and isoleucine degradation and endocytosis in primary vs rec

109 uterated apart from (1)H/(13)C NMR probes at isoleucine delta1 methyl groups, which facilitated (1)H/

110 36-bp operator fragments are consistent with isoleucine-dependent binding of two CodY dimers per dupl

111 Isoleucine deprivation results in GCN2-mediated phosphor

112 xo-phytodienoic acid, jasmonic acid, and its isoleucine derivative increased in roots upon osmotic an

113 Isoleucine did not affect energy intake.

114 soleucyl-L-leucine dipeptide; (g) L-leucyl-L-isoleucine dipeptide.

115 tory MREI (methionine-arginine-glutamic acid-isoleucine) domain, highly expressed in the central nerv

116 emoglobin; however the parasite must acquire isoleucine exogenously, because this amino acid is not p

117 leucine; (d) L-leucine; (e) L-leucine plus L-isoleucine; (f) L-isoleucyl-L-leucine dipeptide; (g) L-l

118 s) that incorporate the beta-keto acid and l-isoleucine, followed by Dieckmann condensation, to form

119 ino acids (BCAAs, i.e., valine, leucine, and isoleucine) function as nitrogen donors to generate macr

120 ggest that apoCaM interacts with a conserved isoleucine-glutamine (IQ) motif in the C terminus of the

121 interacts with calmodulin via its N-terminal isoleucine-glutamine (IQ) motif.

122 h recent implication of short glycine-serine-isoleucine (GSI) containing motifs.

123 tion of the isomeric amino acids leucine and isoleucine had markedly different effects on ethanol sen

124 ive gene expression by the bioactive form JA-isoleucine have been well-studied, knowledge on JA metab

125 rce of tryptophan, phenylalanine + tyrosine, isoleucine, histidine, but limiting for lysine, leucine,

126 cid substitutions at D1416 in the IHD motif (isoleucine-histidine-aspartic acid) in the NBARC domain

127 te these proteins containing leucine (L) and isoleucine (I) as LIL proteins.

128 group 1 dandelion PPOs possess a hydrophobic isoleucine (I) at position HB2+1, group 2 PPOs exhibit a

129 mV, respectively, by the size of a conserved isoleucine (I126) in the S1 segment, thus indicating the

130 emization of Asp, as well as racemization of isoleucine (Ile) and phenylalanine (Phe) after 100 s of

131 ate family of growth regulators includes the isoleucine (Ile) conjugate of jasmonic acid (JA-Ile) and

132 ne (Val) in their propensity to mistranslate isoleucine (Ile) in proteins.

133 n ALDH10s with low BADH activity, because an isoleucine (Ile) pushes the Trp against the Tyr.

134 e-chain dihedral angles of leucine (Leu) and isoleucine (Ile), and identify those conformations that

135 branched-chain amino acids (BCAAs) leucine, isoleucine (Ile), and valine (Val) in the mitochondria e

136 f isobaric residues (Xle): leucine (Leu) and isoleucine (Ile).

137 and brain scaffolding protein, KIBRA, has an isoleucine (Ile-81) rather than a second conserved trypt

138 re heavily influenced by Asp(399) and the di-isoleucines, Ile(402) and Ile(403).

139 Our data show that alteration of the isoleucine (Ile172) did not affect the basal ATPase acti

140 an in-frame deletion of a conserved Galpha11 isoleucine (Ile200del), and one of the nine unrelated pa

141 c route to provide a substantial fraction of isoleucine in a wild-type strain when propionate is avai

142 s revealed a possible role for valine and/or isoleucine in CI tolerance.

143 Wounded pho1 leaves hyperaccumulated JA/JA-isoleucine in comparison with the wild type.

144 directly controls biosynthesis of jasmonoyl-isoleucine in JA-mediated defense responses and interact

145 differentiation between isomeric leucine and isoleucine in peptide sequencing utilizes multistage ele

146 to contain 4 or 5 basic residues as well as isoleucine in the +2 position: (RRQKR downward arrowFI)

147 Lys), methionine (Met), threonine (Thr), and isoleucine involves monofunctional Asp kinases (AKs) and

148 Acyl chloride of N-phthaloyl-(S)-isoleucine is an efficient chiral auxiliary for the reso

149 ater spray-induced accumulation of JA and JA-isoleucine is directly controlled by MYC2/MYC3/MYC4 thro

150 Decreased isoleucine is of particular interest as a potential cont

151 We report that when isoleucine is withdrawn from the culture medium of intra

152 ive1 (COI1) that recognizes both jasmonoyl-l-isoleucine (JA-Ile) and the bacterial-produced phytotoxi

153 We found that the COR and jasmonate isoleucine (JA-Ile) co-receptor JAZ2 is constitutively e

154 Jasmonoyl-isoleucine (JA-Ile) has been identified as a specific li

155 Jasmonoyl-isoleucine (JA-Ile) is a phytohormone that orchestrates

156 rs tested while MJ and another JA agonist JA-isoleucine (JA-Ile) only affect some reporters.

157 The binding of jasmonoyl-L-isoleucine (JA-Ile) to the F-box of CORONATINE INSENSITI

158 The main hormonal signal, jasmonoyl-L-isoleucine (JA-Ile), has been found recently to undergo

159 e responses to the plant hormone jasmonoyl-L-isoleucine (JA-Ile).

160 ine, glycine, histidine, total homocysteine, isoleucine, kynurenine, leucine, lysine, methionine, met

161 reported to catalyze the hydroxylation of l-isoleucine, l-leucine, and l-alpha-amino-delta-carbamoyl

162 l-isoleucine, l-valine, l-aspartic and ubiquitin carboxyl-

163 Changes in beta-hydroxybutyrate, isoleucine, lactate, and pyridoxate were blunted in thos

164 (positive association), followed by leucine/isoleucine (Leu/Ile) (negative association).

165 thod, which is referred to as VILMHA (valine isoleucine leucine methyl hydrogen analysis), was tested

166 concentrations of phenylalanine, glutamine, isoleucine, leucine and glycerophosphocholine.

167 We found that isoleucine, leucine and tyrosine levels were significant

168 associated with a pair of large clusters of isoleucine, leucine and valine (ILV) side chains located

169 us aureus in response to the availability of isoleucine, leucine and valine (ILV), and GTP.

170 s, amino acid scoring (FAO, 2013) indicated, isoleucine, leucine and valine as the limiting amino aci

171 sheep, including branched chain amino acids (isoleucine, leucine and valine) that have been identifie

172 clusters of branched aliphatic amino acids [isoleucine, leucine, and valine (ILV) clusters] were fou

173 e cluster of branched aliphatic side chains, isoleucine, leucine, and valine (ILV).

174 sma levels of the branched-chain amino acids isoleucine, leucine, and valine are associated with Alzh

175 BCAAs (i.e., isoleucine, leucine, and valine) and their downstream me

176 the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and valine) are strongly associated

177 re optimized for the resolution of the BCAAs isoleucine, leucine, and valine, as well as 13 other ami

178 etection (LOD) were 400, 200, and 100 nM for isoleucine, leucine, and valine, respectively.

179 tor specific for the hydrophobic amino acids isoleucine, leucine, and valine.

180 s(-1)) are observed in the methyl groups of isoleucine, leucine, and valine.

181 Arginine, lysine, isoleucine, leucine, methionine, phenylalanine, valine,

182 Prior classification of peaks as either from isoleucine, leucine, or valine reduces the search space

183 rum values for a-amino-butyric acid, valine, isoleucine, leucine, tyrosine, phenylalanine, ornithine

184 r impaired branched-chain amino acid (BCAAs; isoleucine, leucine, valine) metabolism in obesity, insu

185 higher levels of stress-related amino acids (isoleucine, leucine, valine, and proline), sugars, inter

186 henylalanine, tryptophan, tyrosine, alanine, isoleucine, leucine, valine, aspartate, and glutamate) w

187 The 5-amino acid (AA) signature, including isoleucine, leucine, valine, tyrosine, and phenylalanine

188 ation between baseline circulating levels of isoleucine, leucine, valine, tyrosine, and phenylalanine

189 ll-surface CXCR4 in neuroblastoma cells: the isoleucine-leucine motif at residues 328 and 329 and res

190 1 inhibitors and the mutation of the FXIII-A Isoleucine-Leucine-Aspartate-Threonine (ILDT) motif prev

191 ned by comparing the peak area of the valine/isoleucine/leucine methyl groups to an external, certifi

192 leotide polymorphisms (SNPs) associated with isoleucine levels and one SNP associated with both leuci

193 to 114.16 (92.89-143.52) microM (P = .004), isoleucine levels increased from 20.43 (10.92-27.41) mic

194 at a genetic predisposition to raised plasma isoleucine levels is positively associated with AD.

195 ally predicted one standard deviation higher isoleucine levels was 1.35 (95% CI, 1.08-1.69; p = 0.007

196 interaction site to amino acid 52 of VP1, an isoleucine located within a sequence motif IDPWI in the

197 The branched-chain amino acids leucine and isoleucine lower blood glucose after oral glucose ingest

198 biosynthesis of histidine, valine, leucine, isoleucine, lysine and proline pre-determines the relian

199 3 tail: the segment at residues 11-27 and an isoleucine-lysine nuclear localization signal (IK-NLS) m

200 The KLR models also indicate that isoleucine may act as a domain-capping residue.

201 The growth trends of tryptophan and isoleucine metaclusters, along with serine, asparagine,

202 n the RYGB surgery group, changes in leucine/isoleucine, methionine, phenylalanine, and glucagon-like

203 er transitions using 17 isotopically labeled isoleucine methyl groups and three tryptophan side chain

204 s independently from JA-isoleucine or any JA-isoleucine mimic.

205 ine kinase inhibitor-refractory threonine-to-isoleucine mutation at position 315 (T315I).

206 Gene sequencing revealed a phenylalanine-->isoleucine mutation in the 33rd position of exon 2 of TT

207 Moreover, introduction of isoleucine mutations in the C-terminal heptad repeat to

208 e bulkier phenylalanine (fingers domain) and isoleucine (N-terminal domain) could induce a tendency t

209 ophobic pocket in the apple 2 domain and the isoleucine occupies a flanking minor pocket.

210 tic side chains such as valine, leucine, and isoleucine of putative substrates.

211 est this assumption, we examined the role of isoleucine on DNA binding, bending and catalytic activit

212 e intragastric administration of leucine and isoleucine on the gastric emptying of, and blood glucose

213 in the roots that acts independently from JA-isoleucine or any JA-isoleucine mimic.

214 accumulates a Val(*); mutation of Val172 to isoleucine or cysteine results in accumulation of an Ile

215 s (1.04 [1.00-1.08]), and no association for isoleucine or valine (0.99 [0.95-1.03] and 1.00 [0.96-1.

216 eveals DinB2-like polymerases, with leucine, isoleucine or valine steric gates, in many taxa of the p

217 t hemoglobin (Hb A) was replaced by leucine, isoleucine, or phenylalanine.

218 acid signature composed of arginine, leucine/isoleucine, phenylalanine, tyrosine, valine and proline

219 e sensor of Domain III allows binding of the isoleucine-phenylalanine-methionine (IFM) motif to the i

220 ences for some metabolites (valine, leucine, isoleucine, proline, and malic acid).

221 o recycling endosomes via a novel N-terminal isoleucine-proline (IP) motif.

222 a conserved four amino acid motif, (serine-X-isoleucine-proline) which exists within an intrinsically

223 niosomal and liposomal nanovesicles loading Isoleucine-Proline-Proline (IPP) as suitable ingredients

224 In healthy subjects, both leucine and isoleucine reduced blood glucose in response to a mixed-

225 The lipid-derived phytohormone jasmonoyl-isoleucine regulates plant immunity, growth and developm

226 nding PDZ domains is the accommodation of an isoleucine residue at the C-terminal position (P(0)), a

227 cificity of CnCda4 by converting an atypical isoleucine residue in a flexible loop region to the bulk

228 biophysical approaches, we have uncovered an isoleucine residue in the kinase domain of the Tec famil

229 impacts were specific to substitutions with isoleucine residues because functional modulation was pa

230 Conserved isoleucine residues in the center of the pore serve as t

231 that the first layer of the highly conserved isoleucine residues in the filter is primarily responsib

232 f helix-destabilizing, ss-branched valine or isoleucine residues within the TMD restores normal secre

233 To mimic interacting leucine and isoleucine residues, we have created new amino acids tha

234 formation with a hinge region around the two isoleucine residues.

235 lkyl aryl ether linkage between the dopa and isoleucine residues.

236 mediated by the GCI (glycine, cysteine, and isoleucine) residues (188-190) of RhoB.

237 The structure of CodY in complex with isoleucine revealed a reorganized GAF domain.

238 transcriptional co-repressor through leucine/isoleucine-rich motifs that are functionally independent

239 ne, alanine, valine, leucine, phenylalanine, isoleucine, serine, tryptophan, methionine, and cysteine

240 acid L-isoleucine and the peptide L-leucyl-L-isoleucine showed greater efficiency in translocating GL

241 length is governed by the conformation of an isoleucine side chain at the end of the tunnel.

242 We suggest that this isoleucine side chain in the Tec family kinases acts as

243 ergetic barrier to activation imposed by the isoleucine side chain.

244 tope labeling of the delta1 methyl groups of isoleucine side chains demonstrates that, in solution, N

245 g kinetic CPMG NMR spectroscopic data for 17 isoleucine side chains distributed over all parts of GCK

246 ay does not directly promote survival during isoleucine starvation.

247 (8a-8c) requires the involvement of an allo-isoleucine stereoisomer and suggests the intriguing poss

248 tely 4% of black Americans carry a valine-to-isoleucine substitution (V122I) in the transthyretin pro

249 the majority of U.S. subjects with valine-to-isoleucine substitution at position 122 (Val122Ile) (n =

250 is entirely dependent on a phenylalanine-to-isoleucine substitution at position 427 in the fusion su

251 beta receptor mutant containing a leucine-to-isoleucine substitution in its transmembrane domain, whi

252 e of the additional carbon introduced by the isoleucine substitution.

253 -chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energ

254 to glutamic acid (K to E), threonine 259 to isoleucine (T to I) and serine 262 to proline (S to P) t

255 oncurrent reduction of the BCAAs leucine and isoleucine, the AAAs tyrosine and phenylalanine, and 4 o

256 hen it is supplemented with 50 mug/ml l-allo-isoleucine, the starting unit for CMA production.

257 changes in the metabolism of valine/leucine/isoleucine; the jejunum, skeletal muscle, and liver had

258 s supported the transformation of valine and isoleucine to isobutylamine and 2-methylbutylamine as re

259 mine to leucine substitution (Q4594L) and an isoleucine to methionine substitution (I4790M) in highly

260 The missense isoleucine to threonine substitution at position 73 (I73

261 ge-gated potassium channel Kv1.1 converts an isoleucine to valine codon for amino acid 400, speeding

262 with an amino acid change at residue 19 from isoleucine to valine induced KPNA1 degradation.

263 cing showed that noddy mutant mice harbor an isoleucine-to-asparagine (I108N) mutation in the EC1 rep

264 41 SOSIP (gp120-gp41 disulfide [SOS] with an isoleucine-to-proline mutation [IP] in gp41) alone, as w

265 that are stabilized by a disulfide bond, an isoleucine-to-proline substitution at residue 559 and a

266 TERF6 and an RNA sequence in the chloroplast isoleucine transfer RNA gene (trnI.2) located in the rRN

267 The hormone JA-isoleucine triggers the interaction of JAZ repressor pro

268 Deletion of a highly expressed isoleucine tRNA similarly altered these signaling pathwa

269 llowed by specific sequences of leucines and isoleucines, two hydrophobic amino acids that differ onl

270 Alanine, leucine, isoleucine, tyrosine, and glutamine predicted incident t

271 The serum levels of valine, leucine, isoleucine, tyrosine, and phenylalanine were measured in

272 ended pattern except for cystine/methionine, isoleucine, tyrosine/phenylalanine, lysine and threonine

273 oproteins, citrate, tyrosine, phenylalanine, isoleucine, valine and glucose were identified and consi

274 t levels of glucose at 120 min, and leucine, isoleucine, valine and proline at 90 and 120 min, wherea

275 through reduced branched-chain AAs (leucine, isoleucine, valine).

276 The branched chain amino acids leucine, isoleucine, valine, and alloisoleucine were significantl

277 atically replace 29 membrane-facing leucine, isoleucine, valine, and phenylalanine residues in the tr

278 glycine, histidine, phenylalanine, leucine, isoleucine, valine, and tyrosine) were assessed with the

279 5 essential amino acids 3 times/d (leucine, isoleucine, valine, lysine, and threonine) (HFrAA) or wi

280 strongly require supplementation of leucine, isoleucine, valine, methionine, and threonine and modest

281 The essential amino acids: tryptophan, isoleucine, valine, phenylalanine, leucine, threonine, l

282 accumulation of many amino acids, including isoleucine, valine, threonine, and 4-aminobutanoate, whi

283 of the neighboring LRRFIP2, and marked by an isoleucine-valine missense variant in MLH1.

284 mino acid moieties, such as methyl groups of isoleucines, valines, or leucines.

285 2) was imbued largely by a single leucine-to-isoleucine variation at position G.H5.23.

286 Galpha(13) is defined by a single leucine-to-isoleucine variation.

287 ith this, levels of wound-response jasmonoyl-isoleucine were enhanced in the mutant, as was defense a

288 required for the biosynthesis of leucine and isoleucine, were decreased in strains lacking BSH.

289 thetical isomer pairs, including leucine and isoleucine, whereas their stereoisomers (d- and l-forms)

290 DNA by as much as 150 degrees ; an invariant isoleucine, which has been seen structurally to intercal

291 In ATP8A2, the corresponding residue is an isoleucine, which recently was found mutated in patients

292 the domain-11 IGF2 binding site by replacing isoleucine with alanine in the CD loop (exon 34, I1565A)

293 or more conserved lysines or replacement of isoleucine with alanine or valine alters the ability of

294 hierarchical regression revealed decreasing isoleucine with ascent alongside increasing lactate and

295 cell lines, valine with high expression and isoleucine with low expression.

296 eucine and postmenopausal breast cancer, and isoleucine with pancreatic cancer.

297 domains, such as the widely used GCN4-based isoleucine zipper (IZ) and the T4 bacteriophage fibritin

298 l activation via a trimerized membrane-bound isoleucine zipper (TMZ) CD40L.

299 F TM domain revealed a heptad repeat leucine-isoleucine zipper motif (LIZ).

300 ng cancer cells as highly active recombinant isoleucine-zipper-tagged TRAIL (iz-TRAIL).