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1  defects of cells lacking the divergent Ulp2 isopeptidase.
2 tin binding subunit, and dUCH37, a ubiquitin isopeptidase.
3  peptides except for one were cleaved by the isopeptidase.
4  is serving as a recognition element for the isopeptidase.
5 mer of benenodin-1 is cleaved by its cognate isopeptidase.
6  identified it as an allele of the ULP2 SUMO isopeptidase.
7 bal), an inhibitor of many ubiquitin-protein isopeptidases.
8 y rivaling the efficiency of the most active isopeptidases.
9  and cleaved by enzymes called lasso peptide isopeptidases.
10  determined at the level of deconjugation by isopeptidases.
11 /RanBP2 that preferentially protects it from isopeptidases.
12 disassembled slowly by proteasome-associated isopeptidases.
13 sopeptide-containing reagents for validating isopeptidase activities and quantifying substrate specif
14  have both deubiquitinating and deISGylating isopeptidase activities in addition to proteolytic activ
15 All three enzymes were found to display good isopeptidase activities, with Km values of 10(-4) to 10(
16 olog, has SUMO C-terminal hydrolase and SUMO isopeptidase activities.
17 ere detected; notably, in addition to UCH-D, isopeptidase activity [ubiquitin-(epsilonN)-lysine cleav
18                               We demonstrate isopeptidase activity against K48-linked tetraubiquitin
19                        In vivo, SENP5 showed isopeptidase activity against SUMO-2 and SUMO-3 conjugat
20 terochromatin protein 1 alpha (HP1alpha) and isopeptidase activity against SUMO-modified HP1alpha.
21 ere then assayed for inhibition of ubiquitin isopeptidase activity and antineoplastic effects.
22       The punaglandins were shown to inhibit isopeptidase activity and exhibit antiproliferative effe
23 ctive DUBs for threonine esterase and lysine isopeptidase activity and find that most DUBs demonstrat
24 been proposed to provide the active site for isopeptidase activity associated with the Rpn11/POH1 sub
25                Transgenic inhibition of CSN5 isopeptidase activity blocks breast cancer progression e
26 e other SENP family members, SENP7S has SUMO isopeptidase activity but unlike full-length SENP7L, SEN
27 proNEDD8 precursor to its mature form and an isopeptidase activity deconjugating NEDD8 from substrate
28 y the enzymes, indicating that expression of isopeptidase activity did not require unusual protein co
29                 These results highlight CSN5 isopeptidase activity in breast cancer progression, sugg
30  the use of gamma-glutamyltranspeptidase and isopeptidase activity in leech saliva, we could show tha
31  that Uch37 is responsible for the ubiquitin isopeptidase activity in the PA700 (19S) proteasome regu
32       Furthermore, SENP5 showed more limited isopeptidase activity in vitro.
33                      Here, we show that CSN5 isopeptidase activity is essential for breast epithelial
34 ssembly of the full COP9 signalosome and the isopeptidase activity of CSN5, which potentiates the tra
35 e discovered that they inhibit the ubiquitin isopeptidase activity of the proteasome pathway.
36 as shown to preferentially inhibit ubiquitin isopeptidase activity of the proteasome pathway.
37 emoval of polyubiquitin moieties through the isopeptidase activity of the subunit Rpn11.
38  physically binds SUMO and displays in vitro isopeptidase activity on poly-SUMO chains.
39 etween FAT10 and OTUB1 not only enhanced its isopeptidase activity toward Lys-48-linked ubiquitin moi
40 and USP36 the first human DUBs with specific isopeptidase activity toward three distinct modifiers.
41 y regulates IFN signaling independent of its isopeptidase activity towards ISG15.
42 ) and removing conjugated SUMO from targets (isopeptidase activity).
43          Whereas CSN-dependent CSN5 displays isopeptidase activity, it is intrinsically inactive in o
44 nsaturated ketone, was a potent inhibitor of isopeptidase activity, whereas PGA(1) and PGA(2) with si
45 n5 subunit was found to underlie CSN's Nedd8 isopeptidase activity.
46 reover, the centrosomes contain an ubiquitin isopeptidase activity.
47 hese peptides is dispensable with regards to isopeptidase activity.
48 ght-subunit protein complex containing Nedd8 isopeptidase activity.
49    Thus, SENP5 also possesses limited SUMO-1 isopeptidase activity.
50 ect of USP13 on Siah2 is not mediated by its isopeptidase activity: mutations in its ubiquitin-bindin
51 f small, ubiquitin-related modifier-specific isopeptidases (also known as sentrin-specific proteases,
52 racts with the endosome-associated ubiquitin isopeptidase AMSH, and the coexpression of AMSH or its C
53 how the opposing actions of a localized SUMO isopeptidase and a STUbL regulate rDNA silencing by cont
54     UBP43 belongs to the family of ubiquitin isopeptidases and specifically cleaves ISG15, a ubiquiti
55 e pharmacophore hypothesis, inhibit cellular isopeptidases, and cause cell death independently of p53
56 ns is challenging because of the activity of isopeptidases, and often only a small fraction of a targ
57                             We also use this isopeptidase as a tool to study evolutionary relationshi
58                   Furthermore, it identifies isopeptidases as novel targets for the development of an
59     We identified SMT4, which encodes a SUMO isopeptidase, as a high copy suppressor of both the temp
60                    The method simplifies the isopeptidase assay and facilitates high-throughput analy
61 cture-activity analysis of the lasso peptide isopeptidase AtxE2 from Asticcacaulis excentricus, we so
62 only the distal end of (poly)Ub chains, this isopeptidase can selectively rescue poorly ubiquitinated
63 conjugation is reversed by the deconjugating isopeptidase Cap3 (CBASS associated protein 3).
64 inhibitors, and that inhibitors of ubiquitin isopeptidases cause cell death in vitro independently of
65 ession of SENP2, but not other SUMO-specific isopeptidases, causes a defect in chromosome congression
66 interacting with the deubiquitylating BRCC36 isopeptidase complex (BRISC), although it is unclear whe
67 K63)-deubiquitinating enzyme complex, Brcc36 isopeptidase complex (BRISC), attenuates HSC expansion t
68 tivity was intrinsic to PA700 and the Brcc36 isopeptidase complex (BRISC), but that the CSN-associate
69 A1-RAP80 complex, and the cytoplasmic BRCC36 isopeptidase complex (BRISC).
70                     BRISC (Brcc36-containing isopeptidase complex) is a four-subunit deubiquitinating
71                              Potentially, an isopeptidase could influence degradation by 'editing' (p
72 8 and Ile44 in the distal-end Ub contact the isopeptidase directly.
73                                        PA700 isopeptidase disassembles Lys 48-linked polyubiquitin sp
74 and by a mutation in a proteasome-associated isopeptidase (doa4).
75 or Nup358/RanBP2 binding, or by manipulating isopeptidase expression levels, paralog-selective modifi
76 tivity, allowing it to be uncoupled from its isopeptidase function.
77                                          The isopeptidase gene can be used to facilitate genome minin
78  peptide biosynthetic enzymes, lasso peptide isopeptidase has broad substrate specificity.
79                                      2) SUMO isopeptidases have little substrate specificity.
80 ates; and (iv) distinct ubiquitin C-terminal isopeptidase/hydrolase activities, including potent ubiq
81        The specificity of the ubiquitin (Ub) isopeptidase in the PA700 regulatory complex of the bovi
82 ates, validating that USP18 is a major ISG15 isopeptidase in vivo.
83 ively little is known about the role of SUMO isopeptidases in genome maintenance and their role in co
84  that specificity determinants for the PA700 isopeptidase include Leu8, Ile44, and Lys48 on the dista
85 shown to exert its regulatory function in an isopeptidase-independent manner.
86                         It is theorized that isopeptidase inhibition and general cytotoxicity of pros
87 nes structurally related to the nonselective isopeptidase inhibitor G5 were synthesized and tested fo
88                 However, G5, a non-selective isopeptidase inhibitor, triggers a distinct necrotic pat
89 ression vector after which ubiquitin-protein isopeptidase inhibitor, Ubal, and expression vector were
90 nfers activity among this class of ubiquitin isopeptidases inhibitors, and that inhibitors of ubiquit
91                                Lasso peptide isopeptidase is an enzyme that specifically hydrolyzes t
92 his latter possibility we find that the WSS1 isopeptidase is required for suppression by ulp2Delta.
93  identity and 54.8% amino acid identity to n Isopeptidase (ISOT-1).
94 nthreaded astexin-2, demonstrating that this isopeptidase must recognize a knotted structure in order
95 a high copy suppressor selection with a SUMO isopeptidase mutant, and tandem mass spectrometry to def
96 d electrophilic beta-carbons, do not inhibit isopeptidases or cause significant cell death.
97                   Generic inhibition of SUMO isopeptidases or depletion of the SUMO isopeptidase SENP
98 ubiquitin recycling by proteasome-associated isopeptidases, our results indicate that ubiquitin is re
99                         We propose that JAMM isopeptidases play important roles in a variety of physi
100 Ub aldehyde (Ubal), a synthetic inhibitor of isopeptidases (proteases that hydrolyze the bond between
101 .4 A resolution structure of a lasso peptide isopeptidase revealing a topologically novel didomain ar
102 and also occurs if Ub aldehyde occupies this isopeptidase's active site.
103 es, it can be disassembled to Ub monomers by isopeptidase(s) in a red blood cell extract.
104 lpha-subunit proteolysis by inhibition of an isopeptidase(s) that deubiquitinates, or "edits," Ub-3H-
105 by the 26S proteasome; and disassembly by Ub isopeptidase(s) to regenerate the protein substrate.
106          High Ubal concentrations inhibit an isopeptidase(s) which normally disassembles "unanchored"
107                                SUMO-specific isopeptidase SENP-1 further enhances the synergy between
108 ng GluR6 SUMOylation using the SUMO-specific isopeptidase SENP-1 prevents kainate-evoked endocytosis
109 d, mutating these lysines or adding the SUMO isopeptidase SENP1 dramatically increased both native an
110  SUMO isopeptidases or depletion of the SUMO isopeptidase SENP1 enhances sumoylation of Ran in semi-p
111 l ubiquitin-related modifier (SUMO)-specific isopeptidases SENP1 and SENP2 are targeted to kinetochor
112 y regulate SAC proteostasis through the SUMO-isopeptidases SENP1 and SENP2 at NPCs.
113  in excised PM patches are activated by SUMO isopeptidase (SENP1) and resilenced by SUMO1.
114 ligases (UBA2 and Ubc9) or the sumo specific isopeptidases (SenP1-3).
115 g of ALT multitelomeres through facilitating isopeptidase SENP6-mediated SUMO deconjugation at telome
116 ysiologically significant constraint on SUMO isopeptidase specificity.
117 at is sufficient to impose on CSN5 an active isopeptidase state.
118                                              Isopeptidase T (IPaseT) can hydrolyze isopeptide bonds o
119 abbit reticulocyte deubiquitinating enzymes: isopeptidase T (IPaseT), a member of the gene family of
120                   Unlike the BUZ domain from isopeptidase T (isoT) that contains a single zinc finger
121 ubstrate preferences of two DUBs, UCH-L3 and isopeptidase T (IsoT), were profiled using a positional
122  subunit of G proteins (GNB3), and ubiquitin isopeptidase T (ISOT), with known functions, and two new
123 n (ZnF UBP) from the deubiquitinating enzyme isopeptidase T (IsoT, or USP5) alone and in complex with
124                                              Isopeptidase T (IsoT/USP5) is a deubiquitinating enzyme
125 s stable and tightly bound recombinant human Isopeptidase T (USP5), a deubiquitinating enzyme known t
126                        Ectopic expression of Isopeptidase T (USP5), which is known to degrade unancho
127 ion, e.g., the deubiquitinating enzymes USP5/isopeptidase T and USP7/HAUSP and the ubiquitin ligases
128                     Finally, Ubp14 and human isopeptidase T are shown to be functional homologs by co
129                       TTN6 is related to the isopeptidase T class of deubiquitinating enzymes that re
130 ic tri-Ub resists hydrolysis by the PA700 or isopeptidase T deubiquitinating enzymes, it can be disas
131                    We propose that Ubp14 and isopeptidase T facilitate proteolysis in vivo by prevent
132                                      A novel Isopeptidase T gene (ISOT-3) has been identified on huma
133 iculocyte lysate are specific substrates for isopeptidase T in lysates.
134     In the presence of 0.5 microM ubiquitin, isopeptidase T was inhibited by several of the dimer ana
135                 In the absence of ubiquitin, isopeptidase T was inhibited only by the dimer linked th
136                                              Isopeptidase T was shown to specifically disassemble two
137 ockdown of the deubiquitinating enzyme USP5 (isopeptidase T) results in an increase in the level and
138 e identified as Ubp14, the yeast ortholog of Isopeptidase T, and Ufd3, a member of the ubiquitin-fusi
139  binds to ubiquitin-conjugating enzyme-9 and isopeptidase T-3, enzymes involved in small ubiquitin-re
140  conjugates was similar to that observed for isopeptidase T.
141  in vitro, a specificity shared by mammalian isopeptidase T.
142                     The Ub-specific protease isopeptidase T/USP5 is shown to react with ISG15-VS.
143                        The ZnF UBP domain of isopeptidase-T showed no linkage specificity for poly-Ub
144 quitin-like proteins (Ubls) are regulated by isopeptidases termed deubiquitinases (DUBs) and Ubl prot
145 eas SENP2 and -5-7 have substantially higher isopeptidase than endopeptidase activities.
146 esults suggest that Wss1 is a SUMO-dependent isopeptidase that acts on sumoylated substrates as they
147                    Here we describe a bovine isopeptidase that is well suited to such an editing func
148 phogenesis 9 (COP9) signalosome 5 (CSN5), an isopeptidase that removes neural precursor cell-expresse
149  that this enzyme, AtxE2, is a lasso peptide isopeptidase that specifically hydrolyzes astexins-2 and
150 NAi analysis identified three NEDD8-specific isopeptidases that, when knocked down, suppress apoptosi
151                   Ubp43 is an ISG15-specific isopeptidase, the expression of which is activated by IF
152                                              Isopeptidases, the enzymes that reverse the actions of C
153                        Thus, protection from isopeptidases, through interactions with SUMO-binding pr
154 dopeptidase to process the pre-SUMO or as an isopeptidase to deconjugate SUMO from its substrate.
155 ouse model that is lacking an ISG15-specific isopeptidase to study the biological role of the protein
156 pposing activities of Rsp5 and the ubiquitin isopeptidase Ubp2, which are known to assemble and disas
157   However, mutants lacking the SUMO-specific isopeptidase Ulp2 accumulated high molecular weight SUMO
158                        Here we show the SUMO isopeptidase Ulp2 in Saccharomyces cerevisiae does not p
159 irement was observed for mutants of the SUMO isopeptidase Ulp2/Smt4.
160 ng actions of a STUbL (Slx5:Slx8) and a SUMO isopeptidase (Ulp2).
161    ISG15 modification is counteracted by the isopeptidase USP18, a major negative regulator of IFN si
162           The determinants recognized by the isopeptidase were probed by the use of mutant ubiquitins
163 ounteracted by de-ubiquitinating enzymes (or isopeptidases) which selectively remove the polyubiquiti
164                               Unp is a human isopeptidase with still poorly understood biological fun
165 -conjugating enzyme UBE2E3 and the ubiquitin isopeptidase Y (UBPY).
166 ucing adaptor molecule)) and UBPY (ubiquitin isopeptidase Y) have opposite effects on epidermal growt

 
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