ライフサイエンスコーパス: isoprenoid

1 groups of photosynthesis-related plastidial isoprenoids.

2 file of sterols, ubiquinones, and plastidial isoprenoids.

3 ion and the biosynthesis of thermoprotective isoprenoids.

4 an efficient strategy for the production of isoprenoids.

5 ts and produces a large variety of essential isoprenoids.

6 mmon precursors for the synthesis of plastid isoprenoids.

7 tides functionalized with benzophenone-based isoprenoids.

8 tanes+alkylcyclohexanes > cyclic and acyclic isoprenoids.

9 ADP), the precursors for isoprene and higher isoprenoids.

10 ox amino acid sequence with various modified isoprenoids.

11 n the synthesis of cholesterol and nonsterol isoprenoids.

12 idopsis thaliana mainly accumulating primary isoprenoids.

13 y limited pool of substrates based on linear isoprenoids.

14 or biosynthesis of cholesterol and nonsterol isoprenoids.

15 produces cholesterol and essential nonsterol isoprenoids.

16 hophylls, beta-carotene, and stored volatile isoprenoids.

17 anobacteria for photosynthetic production of isoprenoids.

18 pathway that produces cholesterol and other isoprenoids.

19 is interrupted by a highly charged region at isoprenoids 4-7.

20 lts show that statin lowering of prenylation isoprenoids activates caspase-1/IL-1beta inflammasome re

21 an alternative synthetic pathway termed the isoprenoid alcohol (IPA) pathway that centers around the

22 gies underlying efforts to reconstruct plant isoprenoid, alkaloid, phenylpropanoid, and polyketide bi

23 ibe the development and application of a new isoprenoid analogue containing a diazirine moiety that w

24 n living cells enabled by the development of isoprenoid analogues YnF and YnGG in combination with qu

25 lete CsTPS gene models, and tandem arrays of isoprenoid and cannabinoid biosynthetic genes.

26 k expression patterns of nine genes from the isoprenoid and carotenoid biosynthetic pathways were mon

27 mgcs1, which encodes an enzyme necessary for isoprenoid and cholesterol synthesis, causes oligodendro

28 three auxin catabolites, and cytokinins (26 isoprenoid and four aromatic) in response to these compo

29 ome of approximately 30 PG core proteins and isoprenoid and neutral lipids.

30 unction and reveal important clues about how isoprenoid and sterol metabolism is integrated within pl

31 hese BChls were esterified with a variety of isoprenoid and straight-chain alkyl alcohols as in FAPs.

32 ified, including the cytosolic and plastidic isoprenoid and the phenylpropanoid pathways.

33 d interactions with two proteins involved in isoprenoid and thiamine biosynthesis, 1-hydroxy-2-methyl

34 phosphate (MEcPP), a precursor of plastidial isoprenoids and a stress-specific retrograde signaling m

35 Isoprenoids and prenylated proteins have been implicated

36 rescue experiments, we provide evidence that isoprenoids and protein prenylation, but not cholesterol

37 hase (hFPPS) is the gate-keeper of mammalian isoprenoids and the key target of bisphosphonate drugs.

38 it may also play a role in the catabolism of isoprenoids and the mevalonate shunt.

39 ts on bioactive compound content (phenolics, isoprenoids), antioxidant capacity, in vitro biological

40 Isoprenoids are a class of natural products with more th

41 Isoprenoids are an essential and diverse class of molecu

42 All isoprenoids are constructed from two precursors, isopent

43 Isoprenoids are diverse compounds that have their biosyn

44 Isoprenoids are diverse natural compounds, which have va

45 te immunity within the endometrium, and that isoprenoids are regulatory molecules in this process, kn

46 Isoprenoids are synthesised via sequential condensation

47 d (MVA) pathway from which sterols and other isoprenoids are synthesized.

48 Isoprenoids are vital for all organisms, in which they m

49 ause euxinic biomarkers (maleimides and aryl isoprenoids) are present in very low abundance and pyrit

50 terol levels, particularly by the mevalonate-isoprenoid arm of the sterol pathway.

51 cerevisiae for industrial production of the isoprenoid artemisinic acid for use in antimalarial trea

52 ansferase fold with hydrophobic residues for isoprenoid binding and a second binding pocket suitable

53 cretion of intracellularly synthesized model isoprenoid biofuel compounds to the extracellular milieu

54 iting enzyme of the nonmevalonate pathway of isoprenoid biosynthesis (MEP pathway), is a clinically v

55 egulatory role in the mevalonate pathway for isoprenoid biosynthesis and is composed of an endoplasmi

56 of the methylerythritol phosphate pathway of isoprenoid biosynthesis are attractive anti-infective dr

57 roles in native metabolism, engineering for isoprenoid biosynthesis at high flux, titer, and yield r

58 al role that the mevalonate pathway plays in isoprenoid biosynthesis by these archaea.

59 gest a possible basis for the requirement of isoprenoid biosynthesis for the activity of plant miRNAs

60 and ORF4) exhibit significant identity with isoprenoid biosynthesis genes of Bacteria and Archaea.

61 Isoprenoid biosynthesis has thus far been dependent on p

62 Fe4S4] cluster-containing enzyme involved in isoprenoid biosynthesis in many bacteria as well as in m

63 ) pathway supplies precursors for plastidial isoprenoid biosynthesis including carotenoids, redox cof

64 -d-erythrithol-4-phosphate (MEP) pathway for isoprenoid biosynthesis offers interesting prospects for

65 phiphiles tested positive, and some targeted isoprenoid biosynthesis or affected lipid bilayer struct

66 final step of the methylerythritol phosphate isoprenoid biosynthesis pathway is catalysed by the iron

67 Inhibition of isoprenoid biosynthesis repressed P(n) at high temperatu

68 Furthermore, isoprenoid biosynthesis shows a characteristic species d

69 ctoisomerase), a key enzyme in nonmevalonate isoprenoid biosynthesis that is essential in Plasmodium

70 Isoprenoid biosynthesis through the methylerythritol pho

71 or the methylerythritol phosphate pathway of isoprenoid biosynthesis, and find evidence of sexual rep

72 hosphate (DXP), a branch point metabolite in isoprenoid biosynthesis, and is also used in the biosynt

73 ic fever disease characterized by a block in isoprenoid biosynthesis, are poorly understood.

74 methylerythritol phosphate (MEP) pathway of isoprenoid biosynthesis, including the clinically valida

75 on revealed an ancient dependency on plastid isoprenoid biosynthesis, predating the divergence of api

76 ae uses a chemically inefficient pathway for isoprenoid biosynthesis, resulting in yield and producti

77 nthesis, amino acid synthesis, flavonoid and isoprenoid biosynthesis, signaling and homeostasis, and

78 eparated pathways provide the precursors for isoprenoid biosynthesis.

79 A reductase (HMGR) activity, a key player in isoprenoid biosynthesis.

80 organelle involved in fatty acid, heme, and isoprenoid biosynthesis.

81 ting their role in developmentally regulated isoprenoid biosynthesis.

82 d synthesis, glutathione production/cycling, isoprenoids biosynthesis, and folate metabolism in respo

83 rrot taproot and is coexpressed with several isoprenoid biosynthetic genes.

84 recent years are the elucidation of a second isoprenoid biosynthetic pathway [the methylerythritol ph

85 Tanaka et al. show that reengineering of the isoprenoid biosynthetic pathway in E. coli (to bypass th

86 rnesyl pyrophosphate (FPP) production in the isoprenoid biosynthetic pathway in Escherichia coli.

87 Enzymes of the isoprenoid biosynthetic pathway in halophilic archaea re

88 PP) in the primary building reactions in the isoprenoid biosynthetic pathway.

89 ic inhibitors of the plastidic and cytosolic isoprenoid biosynthetic pathways, we demonstrated that t

90 Two of the most important discoveries in isoprenoid biosynthetic studies in recent years are the

91 tify an essential function of the mevalonate-isoprenoid branch of sterol biosynthesis during infectio

92 cessary to furnish the universal five-carbon isoprenoid building block, isopentenyl diphosphate (IPP)

93 isoprenylation from endogenously synthesized isoprenoids but enhances the use of exogenous isoprenols

94 he balance between volatile and non-volatile isoprenoids, but the plastidic DMAPP:IPP ratio is genera

95 The chain lengths of isoprenoid carbon skeletons vary widely from neryl pyrop

96 plex I catalysis with ubiquinones of varying isoprenoid chain length, from 1 to 10 units.

97 yl chain occupying the cavity that binds the isoprenoid chain of the substrate.

98 mmodate almost all of its approximately 50-A isoprenoid chain.

99 Archaea use isoprenoid chains linked via ether bonds to sn-glycerol

100 tion that involves the addition of 20-carbon isoprenoid chains via the enzyme geranylgeranyl transfer

101 omics of macrophages with an improved alkyne-isoprenoid chemical reporter enables large-scale profili

102 These studies demonstrate the utility of isoprenoid chemical reporters for proteomic analysis of

103 -CO2 stresses emit large amounts of volatile isoprenoids compared with those in stress-free condition

104 The biosynthetic pathways to isoprenoid compounds involve transfer of the prenyl moie

105 as a platform for targeting a repertoire of isoprenoid compounds with application as high-value phar

106 Isoprenoids comprise a large class of chemicals of signi

107 Isoprenoids consist of a large class of compounds that a

108 Isoprenoids constitute one of the most diverse classes o

109 ylallyl pyrophosphate (DMAPP), with volatile isoprenoids containing fewer isopentenyl subunits.

110 An isoprenoid-containing chloroform extract of tomato fruit

111 arvae suggests flux control into C10 vs. C15 isoprenoids could be accomplished by these ions in vivo.

112 KAR(1) significantly enhanced total isoprenoid cytokinins under dark conditions in compariso

113 ocyanin, quercetin, kaempferol) and selected isoprenoid derivatives (chlorophyll, carotenoids) in the

114 Many isoprenoid derivatives are indispensable structural and

115 Plastid isoprenoid-derived carotenoids serve essential roles in

116 perception in modulating the accumulation of isoprenoid-derived compounds in tomato (Solanum lycopers

117 d fruit, specifically on the accumulation of isoprenoid-derived compounds.

118 showed decreased accumulation of plastidial isoprenoid-derived pigments, especially carotenoids, and

119 extract of tomato fruit and most individual isoprenoids did not induce electrophile-responsive eleme

120 s chemoprotective for the cell by regulating isoprenoid diphosphate concentrations so that they are m

121 can generate as much as 50% of the cellular isoprenoid diphosphate pool used for protein isoprenylat

122 lls can use exogenous isoprenols to generate isoprenoid diphosphate substrates for protein isoprenyla

123 nsferase discovered that modifies an acyclic isoprenoid diphosphate, geranyl diphosphate (GPP), to yi

124 isoprenols containing an aniline group into isoprenoid diphosphates and protein isoprenylcysteines b

125 trans-prenyl transferases that produce trans-isoprenoid diphosphates from C(5) precursors; the epsilo

126 cis-prenyl transferases that produce the cis-isoprenoid diphosphates involved in bacterial cell wall

127 ddition of the hydrocarbon moiety of allylic isoprenoid diphosphates to the carbon-carbon double bond

128 Small isoprenoid diphosphates, such as (E)-4-hydroxy-3-methyl-

129 sphate synthase (GGDPS), which generates the isoprenoid donor (GGPP), as anti-Rab agents.

130 -prenylating enzyme PagF, in complex with an isoprenoid donor analog and a panel of linear and macroc

131 The isoprenoid donor for protein geranylgeranylation reactio

132 the limits of the IUP for producing various isoprenoid downstream products.

133 , significantly correlated with constitutive isoprenoid emission rates across gradients of drought (r

134 of moderate abiotic stress levels, increased isoprenoid emission rates compete with photorespiration

135 carbon assimilation determines constitutive isoprenoid emission rates in plants and potentially even

136 mated energy pools and constitutive volatile isoprenoid emission rates in two species of eucalypts: E

137 Isoprenoid emission rates were insensitive to mild droug

138 TR-NAR ratio increased, driving constitutive isoprenoid emission until severe drought caused carbon l

139 ts of low-CO2, heat, and drought stresses on isoprenoid emission.

140 differential response of photosynthesis and isoprenoid emissions to progressing drought conditions.

141 determining in vivo carbon availability for isoprenoid emissions, directly shaping global biosphere-

142 erexpression led to only modest increases in isoprenoid end products and in the photosynthetic rate.

143 gulatory enzyme that controls the amounts of isoprenoid end products.

144 ol 4-phosphate pathway for the production of isoprenoids essential for photosynthesis and plant growt

145 hway, catalyzes the biosynthesis of the C-15 isoprenoid farnesyl pyrophosphate (FPP).

146 ar lipids connecting taurine via an amide to isoprenoid fatty acid conjugate of varying composition.

147 tested and was competitive with the highest isoprenoid fluxes reported.

148 l maximum approximately a month earlier than isoprenoid fluxes, which highlights the differential res

149 yses have revealed intricate interactions in isoprenoid formation in the plastid that can be extrapol

150 By inhibiting the mevalonate pathway and isoprenoid formation, statins account for the increase o

151 The more than 50,000 isoprenoids found in nature are all derived from the 5-c

152 at the MEP pathway, in addition to producing isoprenoids, functions as a stress sensor and a coordina

153 ow modulation of the concomitant activity of isoprenoid-generating pathways in plant cells; additiona

154 iated degradation augmented by the nonsterol isoprenoid geranylgeraniol through an unknown mechanism.

155 ein (VCP)/p97 and augmented by the nonsterol isoprenoid geranylgeraniol.

156 act cells, and is augmented by the nonsterol isoprenoid geranylgeraniol.

157 Supply of the isoprenoid geranylgeranyl pyrophosphate to oAbeta(42)-tr

158 In this process, an isoprenoid group is attached to a cysteine near the C te

159 through covalently linked fatty acids and/or isoprenoid groups play crucial roles in all forms of lif

160 Microbial production of isoprenoids has been considered as a promising approach

161 ects on atmospheric chemistry, whereas other isoprenoids have diverse roles ranging from various biol

162 Because many isoprenoids have important biological activities, the ne

163 presence of a di-unsaturated highly branched isoprenoid (HBI) lipid biomarker (diene II) in Southern

164 Isoprenoids (i.e., farnesyl or geranylgeranyl groups) ar

165 is saved carbon toward essential nonvolatile isoprenoids, i.e. beta-carotene and lutein, most probabl

166 Adding C(10) isoprenoids improves vesicle stability even further.

167 o specialized enzymes to efficiently produce isoprenoids in extremely acidic environments.

168 The low yield of isoprenoids in plants makes them difficult for cost-effe

169 isms mediated by essential and non-essential isoprenoids in response to soil water availability and s

170 low the biosynthesis of the large variety of isoprenoids including both primary and specialized metab

171 d are hard to quantify because the degree of isoprenoid inhibition by statins correlates to some exte

172 Heptaprenyl diphosphate (C35 -PP) is an isoprenoid intermediate in the synthesis of both menaqui

173 A new genetic screen has identified an isoprenoid intermediate that accumulates in stressed pla

174 ent of metabolic cross talk, the exchange of isoprenoid intermediates between compartmentalized pathw

175 ls; additionally, it suggests an exchange of isoprenoid intermediates between plastids and peroxisome

176 Because statins inhibit the production of isoprenoid intermediates in the cholesterol biosynthetic

177 ng HMGR, but possibly targets an MEP-derived isoprenoid involved in the early steps of the elicitatio

178 Biological production of isoprenoids is considered to be the most efficient way f

179 roduction, and chemical synthesis of complex isoprenoids is impractical.

180 uctase ERAD such that synthesis of nonsterol isoprenoids is maintained in sterol-replete cells.

181 A wide diversity of isoprenoids is produced in different plant compartments.

182 citation energy, mediated by photoprotective isoprenoids, is an important defense mechanism against d

183 On the other hand, cholesterol, but not isoprenoids, is necessary both for axon ensheathment and

184 inable production of a commercially valuable isoprenoid, limonene.

185 membrane-spanning helices and processing an isoprenoid-linked carbohydrate donor substrate(3,4).

186 iB protein kinase-like family is involved in isoprenoid lipid biosynthesis and is implicated in human

187 ranslational modification whereby non-sterol isoprenoid lipid chains are added, thereby modifying the

188 oes not transport a glycosylated diphosphate isoprenoid lipid.

189 s (important for protein glycosylation), and isoprenoids (lipid moieties responsible for the membrane

190 relation of transgene expression levels with isoprenoid marker metabolites (gene-to-metabolite correl

191 We conclude that intraspecific variation in isoprenoid-mediated photoprotective mechanisms contribut

192 Elucidation of the isoprenoid metabolic pathways is indispensable for the r

193 overies suggest that unforeseen variation in isoprenoid metabolism may be widespread in nature.

194 aluation of the effect of S-carvone on plant isoprenoid metabolism.

195 the quantification of all the well known CK isoprenoid metabolites in four different transgenic Arab

196 and in cancer immunotherapy by responding to isoprenoid metabolites, such as (E)-4-hydroxy-3-methyl-b

197 for the biosynthesis of the more than 55,000 isoprenoid metabolites.

198 e additional pathways of purine, pyrimidine, isoprenoid, methionine, riboflavin, coenzyme A, and fola

199 ethering, tether length, and the presence of isoprenoid methyl groups on one or both lipid tails.

200 Untethered lipids with two isoprenoid methyl tails led to lower PH+/OH- values than

201 Treatment with the isoprenoid mevalonate pathway-intermediates, farnesyl di

202 linking it to nucleotide base and aliphatic isoprenoid modification.

203 Undecaprenol) LLOs, which are composed of an isoprenoid moiety and an oligosaccharide, linked by pyro

204 orientation, structure, and dynamics of the isoprenoid moiety and the oligosaccharide.

205 The isoprenoid moiety shows high flexibility inside the bila

206 Isoprenoid molecules are essential elements of plant met

207 dent alterations are observed in amino acid, isoprenoid, nucleic acid, and vitamin biosynthesis, sugg

208 mediated by DNA anchored by solanesol, a C45 isoprenoid of sufficient length to span the bilayer.

209 t metabolic flux into the synthesis of other isoprenoids of nutritional and industrial interest.

210 Providing geranylgeranyl isoprenoids or inhibiting caspase-1 prevented statin-ind

211 Plant sterols are synthesized via the isoprenoid pathway by cyclization of 2,3-oxidosqualene t

212 Unlike the ubiquitous isoprenoid pathway for the biosynthesis of respiratory q

213 In this study, we engineered a heterologous isoprenoid pathway in E. coli for the high-yield product

214 are specifically activated by phosphorylated isoprenoid pathway metabolites called "phosphoagonists."

215 Here, we present a synthetic isoprenoid pathway that aims to overcome these limitatio

216 x molecules requires substrate flux from the isoprenoid pathway, enzymes involved in late biosyntheti

217 at strontium-substituted BG up-regulated the isoprenoid pathway, suggesting an influence on both ster

218 nt 2-C-methyl-D-erythritol 4-phosphate (MEP) isoprenoid pathway, unexpectedly down-regulated the bios

219 (DXP), an intermediate in the nonmevalonate isoprenoid pathway.

220 that function in independent branches of the isoprenoid pathway.

221 DMADP as precursors for different downstream isoprenoid pathways.

222 to increase the supply of precursors for the isoprenoid pathways.

223 terpenes (Quercus ilex), or that do not emit isoprenoids (Paulownia imperialis).

224 geranyl reductase (GGDR) which restricts the isoprenoid precursor availability.

225 riptional control at each individual step of isoprenoid precursor biosynthesis.

226 (STS)-mediated cyclization of the linear C25 isoprenoid precursor geranylfarnesyl diphosphate (GFPP)

227 valonate pathway for the biosynthesis of the isoprenoid precursor isopentenyl pyrophosphate, 1-deoxy-

228 Synthesis of IPP, an isoprenoid precursor molecule that is a critical interme

229 g that frontalin is derived from a 20-carbon isoprenoid precursor rather than from the 10- or 15-carb

230 lciparum treated with RCB-185 was rescued by isoprenoid precursor supplementation, and treatment subs

231 Isoprenoid precursor synthesis is the only essential rol

232 cetyl coenzyme A (acetyl-CoA, the two-carbon isoprenoid precursor) with a reduced ATP requirement, re

233 and degradation of these molecules and their isoprenoid precursors have not been fully described.

234 ral mechanism to control the biosynthesis of isoprenoid precursors in different plant cell compartmen

235 operating in parallel in plants to generate isoprenoid precursors, has been studied extensively.

236 in the MEP pathway, producing the essential isoprenoid precursors, isopentenyl diphosphate and dimet

237 pathway for the synthesis of their essential isoprenoid precursors.

238 t-2-en-1-yl diphosphate (HMBPP) into the two isoprenoid precursors: isopentenyl diphosphate (IPP) and

239 Volatile isoprenoids produced by plants are emitted in vast quant

240 emical entity serving as both a precursor of isoprenoids produced by the plastidial methylerythritol

241 lline GPPMT, followed by dissociation of the isoprenoid product.

242 mining the specificity and the length of the isoprenoid product.

243 The nonmevalonate pathway is responsible for isoprenoid production in microbes, including H. pylori,

244 (HDR/IspH), the final step of the plastidic isoprenoid production pathway, is not fixed.

245 ity through the introduction of heterologous isoprenoid production pathways into engineered microorga

246 enetically distinct plants, correlating with isoprenoid production patterns.

247 he balance between volatile and non-volatile isoprenoid production remain unknown.

248 To enhance isoprenoid production, computational strain design was c

249 rify FREP by evolving increased tyrosine and isoprenoid production.

250 a show a remarkable metabolic plasticity for isoprenoid production.

251 the MEP pathway and into the major plastidic isoprenoid products in isoprene-emitting and transgenic

252 er IPA pathway for the conversion of IPAs to isoprenoid pyrophosphate intermediates that enabled the

253 dispensable, but statin-induced lowering of isoprenoids required for protein prenylation triggered N

254 In addition, isoprenoid secondary metabolites are highly valuable nat

255 In studying the effects of isoprenoid shortage on IL-1 beta generation, we identifi

256 ental conditions needs to be ascertained but isoprenoids should not be neglected when considering ras

257 ase reaction in the recently discovered "MTA-isoprenoid shunt" that generates 1-deoxy-d-xylulose 5-ph

258 as the substrate, which demonstrates that an isoprenoid side chain enhances enzymatic hydroxylation a

259 for the synthesis of ubiquitous GGPP-derived isoprenoid species.

260 nality assist product dissociation, and that isoprenoid stepping ensures short transit times.

261 Isoprenoid-substituted bisphosphonates are known to serv

262 turally occurring, noncanonical C-methylated isoprenoid substrate, 2-methylgeranyl diphosphate, to fo

263 ting these strains for biosynthesis of other isoprenoids such as beta-farnesene (C15H24), a plant ses

264 hway that produces cholesterol and nonsterol isoprenoids such as GGpp.

265 Many important plant isoprenoids, such as chlorophylls, carotenoids, tocopher

266 nts a metabolic hub for the synthesis of key isoprenoids, such as chlorophylls, tocopherols, phylloqu

267 alyzes the synthesis of sterol and nonsterol isoprenoids, such as cholesterol and ubiquinone, as well

268 acids of the resin and no change in primary isoprenoids, such as sterols, chlorophylls, and caroteno

269 recessive mutations in a novel gene, called isoprenoid synthase domain containing (ISPD), are a rela

270 cessive mutations in the ISPD gene (encoding isoprenoid synthase domain containing).

271 plete polyprenyl transferase subgroup of the isoprenoid synthase superfamily computationally.

272 lyprenyl transferase (E-PTS) subgroup in the isoprenoid synthase superfamily, which provides substrat

273 yl-D-erythritol 4-phosphate (MEP) pathway of isoprenoid synthesis by end products dimethylallyl dipho

274 We used Escherichia coli isoprenoid synthesis H (Protein Data Bank code 3F7T) as

275 ally reduced by either partial inhibition of isoprenoid synthesis pathway by fosmidomycin-feeding or

276 n the methyl erythritol phosphate pathway of isoprenoid synthesis, is essential for Gram-negative bac

277 hylallyl diphosphate, the main precursors to isoprenoid synthesis, through sequential phosphorylation

278 C-methyl-d-erythritol 4-phosphate pathway of isoprenoid synthesis.

279 oreign prenyl pyrophosphate intermediates in isoprenoid synthesis.

280 eta-oxidation and the mevalonate pathway for isoprenoid synthesis.

281 as well as enzymes involved in flavonoid and isoprenoid synthesis.

282 the reductase ERAD pathway and regulation of isoprenoid synthesis.

283 Most groups of isoprenoids synthesized in plastids, and some produced e

284 iU(Pa) and UbiT(Pa) can bind UQ and that the isoprenoid tail of UQ is the structural determinant requ

285 structural differences in chromanol head and isoprenoid tail, polarity, concentration, oxidation time

286 +/OH- values than lipids with only one or no isoprenoid tails.

287 ted gene loci, including several involved in isoprenoid/terpenoid metabolism.

288 osphate (GGPP) is a key precursor of various isoprenoids that have diverse functions in plant metabol

289 IPA pathway provides an alternative route to isoprenoids that is more energy efficient than native pa

290 Carotenoids are isoprenoids that play essential roles in photosynthesis

291 Menaquinones (naphthoquinones, MK) are isoprenoids that play key roles in the respiratory elect

292 Bacteria, plants, and algae produce isoprenoids through the methylerythritol phosphate (MEP)

293 t-translational attachment of geranylgeranyl isoprenoids to Rab GTPases, the key organizers of intrac

294 ed and monounsaturated menaquinones with six isoprenoid units forming the alkyl chain may serve as ch

295 IDI) catalyze the interconversion of the two isoprenoid universal C5 units, isopentenyl diphosphate a

296 Mevalonate (MVA) metabolism provides the isoprenoids used in archaeal lipid biosynthesis.

297 a geranylgeranyl diphosphate (GGPP)-derived isoprenoid, which are generated by the tetrapyrrole and

298 ke myelin, is not known nor is clear whether isoprenoids, which also are products of the cholesterol

299 hly conserved and mediates the production of isoprenoids, which feed into biosynthetic pathways for s

300 diphosphate (2), the universal precursors of isoprenoids, while humans exclusively utilize the altern