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1 protein function and is normally mediated by isoprenylation.
2  may be related to its inhibition of protein isoprenylation.
3 erentiation/function via inhibition of Rap1A isoprenylation.
4 to circumvent statin resistance by targeting isoprenylation.
5 isoprenoid diphosphate pool used for protein isoprenylation.
6 lgeranyl-pyrophosphate to circumvent loss of isoprenylation.
7 ansduction pathways, are the key targets for isoprenylation.
8  an interaction that is dependent on protein isoprenylation.
9 , two lipid phosphate phosphohydrolases, and isoprenylation.
10  GGPP, independent of restoration of protein isoprenylation.
11 s of diabetic nephropathy, by preventing Rho isoprenylation.
12  inhibit cardiac hypertrophy by blocking Rho isoprenylation.
13        (ii) This increase was independent of isoprenylation.
14 iosynthesis of isoprenoid lipids and protein isoprenylation.
15 9a to furnish identical products of carbonyl isoprenylation 1c-3c.
16 ucts of carbonyl crotylation 1b-6b, carbonyl isoprenylation 1c-6c, and carbonyl reverse 2-methyl pren
17 ue to a lovastatin-induced blockade in their isoprenylation, affects lens cell structure and prolifer
18 s) undergo post-translational modifications (isoprenylation and carboxyl methylation) in pancreatic b
19                                        After isoprenylation and endoproteolytic processing, the Ras p
20  results expand on the complexity of protein isoprenylation and highlight the impact of post-isopreny
21 metal (gm/gm) mice, which show deficient Rab isoprenylation and macrothrombocytopenia with few granul
22  calmodulin and recoverin, posttranslational isoprenylation and palmitoylation, autophosphorylation,
23            The ability of statins to prevent isoprenylation and perhaps inhibit of Rho restores/prote
24 malian cells substantially decreases protein isoprenylation and results in defects in cell growth and
25 otein expression and signaling by inhibiting isoprenylation and subsequent membrane targeting.
26  Rab18 guanosine triphosphatase activity and isoprenylation are required for stellate cell LD loss an
27 ilonRI-induced mast cell function and reveal isoprenylation as a new means of targeting allergic dise
28 anylgeraniol is independent of acute protein isoprenylation as judged in experiments employing cell-p
29 cts are related to statin blockade of GTPase isoprenylation, as has been shown in older literature, a
30 show that statins selectively inhibit GTPase isoprenylation at clinically relevant doses, leading to
31 dergo posttranslational modifications (e.g., isoprenylation) at their C-terminal cysteine residues.
32 xy-3-methylglutaryl-Coenzyme A reductase and isoprenylation attenuated, whereas exogenously provided
33 soprenoid diphosphate substrates for protein isoprenylation, but the mechanism, efficiency, and biolo
34 otif to two random peptides results in their isoprenylation by PagF, demonstrating utility as a gener
35           We show that inhibition of protein isoprenylation by statins causes the accumulation of APP
36                        Prevention of protein isoprenylation by the GGpp transferase inhibitor (GGTI-2
37 lational CAAX-processing events that include isoprenylation, C-terminal proteolytic cleavage, and car
38  CaaX motif undergo three processing events: isoprenylation, C-terminal proteolytic cleavage, and car
39     Members of this family contain consensus isoprenylation (CaaX) sites, which we demonstrate are ef
40                                         Rac1 isoprenylation contributes to membrane avidity but is no
41 as PDE6delta was unable to associate with an isoprenylation-deficient mutant IP (IPSSLC).
42 erfere with PKCdelta autophosphorylation was isoprenylation-dependent as determined using the farnesy
43 PKCdelta at the cellular membrane through an isoprenylation-dependent mechanism to negatively regulat
44 is is provided by both de novo synthesis and isoprenylation-dependent mechanisms.
45 nstrate that selective inhibition of protein isoprenylation does not mimic lovastatin's ability to in
46 posttranslational modifications that include isoprenylation, endoproteolytic release of the C-termina
47               Using genetic depletion of the isoprenylation enzymes farnesyltransferase and geranylge
48 normal phenotypes revert to normal when post-isoprenylation events are genetically interrupted.
49 prenylation and highlight the impact of post-isoprenylation events in regulating the function of Ydj1
50 esterol reduction but by suppressing protein isoprenylation events that use cholesterol pathway inter
51 latable CaaX motif that is resistant to post-isoprenylation events.
52 tent of the two proteins that do not require isoprenylation for membrane association&sbd;PDGF-recepto
53                            The importance of isoprenylation for targeting of Ras proteins to the plas
54 , Chp depends on palmitoylation, rather than isoprenylation, for membrane association and function.
55 ional modifications, autophosphorylation and isoprenylation, found in the native bovine RK.
56 A reductase in these cells decreases protein isoprenylation from endogenously synthesized isoprenoids
57           Consistent with N-BP inhibition of isoprenylation, geranylgeraniol or farnesol prevented ac
58                    Atorvastatin reduced Rheb isoprenylation, GTP loading, and membrane localization.
59 phate (GGPP), an isoprenoid used for protein isoprenylation in animal cells, and is a branch point en
60 -positive bacteria and emphasize the role of isoprenylation in bacterial signal transduction.
61                                  Analysis of isoprenylation in cultured human cells shows that AIPL1
62 er, despite numerous studies linking protein isoprenylation in plants to cell cycle control, meristem
63    This study demonstrates the importance of isoprenylation in the regulation of Ag presentation and
64                                 In contrast, isoprenylation inhibition had no effect on the distribut
65                                              Isoprenylation is followed by cleavage of the AAX amino
66 hese results provide the first evidence that isoprenylation is involved in determining levels of intr
67                                         RhoA isoprenylation is necessary for the RhoA-Trio interactio
68 localization and function are dependent upon isoprenylation, may play an important role in mediating
69         The small C-terminal domain bears an isoprenylation motif and is necessary for the interactio
70                  However, replacement of the isoprenylation motif with a bona fide transmembrane anch
71 Ggamma subunits, lacking a carboxyl-terminal isoprenylation motif, are found only in flowering plants
72 stern side of the molecule, three additional isoprenylations occur to form the western and southern r
73 ment of Ras is achieved through an invariant isoprenylation of a C-terminal Cys, supplemented by furt
74                 Moreover, S-carvone hindered isoprenylation of a prenylable GFP indicator protein exp
75 nt, doses statins preferentially inhibit the isoprenylation of a subset of GTPases.
76 emonstrate that inhibition of geranylgeranyl isoprenylation of CaaX proteins in the aqueous outflow p
77 ation requires an intact effector domain and isoprenylation of Cdc42 and Rac1.
78                                              Isoprenylation of gamma(2) and localization of beta(1)ga
79            However, in these p21 null cells, isoprenylation of key substrates of farnesyl transferase
80    Finally, to test the expectation that the isoprenylation of L would increase its hydrophobicity, w
81 actions through their ability to prevent the isoprenylation of members of the Rho family of small G-p
82 ir cholesterol lowering effects, can prevent isoprenylation of Rab-GTPase proteins, a protein family
83                                              Isoprenylation of Rac is also required for efficient int
84 e A (HMG-CoA) reductase and subsequently the isoprenylation of Rac1.
85 ed their intended targets, inhibition of the isoprenylation of Ras and RAP-1A are not sufficient to m
86 ects which may involve interference with the isoprenylation of Ras and Rho GTPases.
87 ion of p21, independent of the inhibition of isoprenylation of Ras or RAP-1.
88 -induced CyPA secretion likely via decreased isoprenylation of small GTPases.
89 altering the ability of FT-alpha to catalyze isoprenylation of targets such as G proteins, lamins, or
90 sequential post-translational modifications: isoprenylation of the cysteine residue, endoproteolysis
91 ergo three coordinated COOH-terminal events: isoprenylation of the cysteine, proteolytic removal of a
92                      Furthermore, C-terminal isoprenylation of the gamma subunit is necessary but not
93 anism by which this occurs is due to reduced isoprenylation of the Ggamma-subunit.
94 atins appear to be mediated by inhibition of isoprenylation of the small GTP-binding proteins such as
95 M cells, in part, by limiting geranylgeranyl isoprenylation of these G-proteins.
96        Although the effects of inhibition of isoprenylation on protein function have been examined, t
97 ulation may result from global inhibition of isoprenylation or depletion of key regulatory isoprenoid
98 ominant negative Rab3D mutants did not alter isoprenylation or membrane association of endogenous Rab
99 AML cells (AMLs) does not correlate with Ras isoprenylation or with activating Ras mutations.
100 he addition of specific intermediates in the isoprenylation pathway reversed this effect, whereas spe
101 ation is the only reversible reaction in the isoprenylation pathway, it could be a site of regulation
102                  In studies addressing which isoprenylation pathway--geranylgeranylation or farnesyla
103 uilding to identify the probable location of isoprenylation, PDE6gamma subunits, and catalytic sites.
104 nfirming that membrane localization, but not isoprenylation per se, is required for function.
105       This was consistent with a blockade in isoprenylation preventing normal association with membra
106                    However, the role of post-isoprenylation protein processing in ABA signal transduc
107 -carboxyl methyltransferase involved in post-isoprenylation protein processing.
108 l modifications, including carboxyl terminal isoprenylation, proteolysis, and methylation.
109                                        After isoprenylation, Ras and other CAAX proteins undergo endo
110 r cellular function as well as substrates in isoprenylation reactions.
111                 Statin inhibition of protein isoprenylation results in decreased Abeta secretion.
112 eldin A or mevastatin and when the conserved isoprenylation sequence (CTIL) at the carboxyl terminus
113 ucts to the plasma membrane via a C-terminal isoprenylation sequence induced PC12 cells to extend neu
114 se into host cells, inactivation of the Rac1 isoprenylation signal that is required for membrane loca
115 ese findings suggest that K-Ras is among the isoprenylation substrates critical for FcepsilonRI-induc
116 t cell function and that K-Ras is a critical isoprenylation target.
117 ds that are alternate substrates for protein isoprenylation that are not inhibitors of squalene synth
118                  In each case with identical isoprenylation, the beta(1)gamma(2) dimer displayed sign
119                                        After isoprenylation, the Ras proteins and other CAAX proteins
120 ma8 is identical with Tbeta1gamma1 in Tgamma isoprenylation, the spatial organization, and the mode o
121 ication by mGBP2 requires GTP hydrolysis and isoprenylation thus, enabling reversible oligomerization
122 ion of RhoA was accompanied by inhibition of isoprenylation via reductions in geranylgeranyl transfer
123                                              Isoprenylation was also demonstrated by (14)C incorporat
124                                           IP isoprenylation was critical for this interaction, as PDE
125 tory production of RK, but posttranslational isoprenylation was deficient.
126 been attributed to the inhibition of Ras/Rho isoprenylation, we have previously shown that statin tox
127 of statins are mediated by the inhibition of isoprenylation, which ensures proper membrane insertion

 
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