ライフサイエンスコーパス: isopropylidene

1 Synthesis of Fmoc-3,4;5,6-di-O-isopropylidene-1-amino-1-deoxy-D-glucitol-gamma-glutamat

2 For poly(7-isopropylidene-2,3-dicarbomenthoxynorbornadiene) the str

3 report here the polymerization of several 7-isopropylidene-2,3-disubstituted norbornadienes, 7-oxa-2

4 trated by the synthesis of a series of 5,6-O-isopropylidene-2-allyl-3-keto-l-galactono-gamma-lactone

5 hodology for the syntheses of D- and l-4,5-O-isopropylidene-2-cyclopentenone (9 and 22), versatile in

6 The utility of D- and l-4,5-O-isopropylidene-2-cyclopentenone is demonstrated by their

7 ocyclopenta[1,3]dioxol-4-one ((4R, 5R)-4,5-O-isopropylidene-2-cyclopentenone) (8), which was achieved

8 ommon bicyclic intermediate (5R,8R,9R)-8,9-O-isopropylidene-2-keto-1,7-dioxaspiro[4.4]nonane (10) tha

9 pyrophosphate (13, 3%) and P1,P2-bis(2',3'-O-isopropylidene-3-(carbamoylphenyl)-5'-ribosyl)py rophosp

10 l-3-keto-l-galactono-gamma-lactone and 5,6-O-isopropylidene-3-allyl-2-keto-l-galactono-gamma-lactone

11 Treatment of a 1,2-O-isopropylidene-3-ketopentofuranose derivative (obtained

12 Treatment of 2',3'-O-isopropylidene-4',5'-unsaturated compounds derived from

13 f the aryl phosphoramidate prodrugs of 2,3-O-isopropylidene-4-erythrono hydroxamate by synthesizing a

14 2,3-O-Isopropylidene-4-erythrono hydroxamate is a potent inhib

15 Wittig olefination of 2',3'-O-isopropylidene-5'-deoxy-5'-uridylaldehyde using this yli

16 lacement of the 5'-mesyl function of 2',3'-O-isopropylidene-5'-O-mesyltiazofurin (24) with the difluo

17 Removal of the isopropylidene acetal and subsequent acetylation gave th

18 diols bearing a 1,2-diol moiety masked as an isopropylidene acetal group and long alkyl chains compri

19 er group in the presence of benzyl ether and isopropylidene acetal protection have also been reported

20 clic dimethyl ether backbone in lieu of the (isopropylidene) acetal moiety characteristic for traditi

21 ith benzylidene acetals on one periphery and isopropylidene acetals on the other had an association c

22 port methods for quantitation of hexose di-O-isopropylidene acetate (IPAc) or pentafluorobenzoyl (PFB

23 n 10 steps from commercially available 2',3'-isopropylidene adenosine.

24 pyridyldimethylglyoximatocobalt-1,2:5,6-di-O-isopropylidene- alpha-D-glucofuranose 4 for the 4:5 epim

25 were synthesized stereoselectively from di-O-isopropylidene-alpha-D-apiose.

26 -di-Boc-hydroxylamine reacts with methyl 1,3-isopropylidene-alpha-d-fructofuranose under Mitsunobu co

27 ochiral selection of 4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-D-pentofuranose (diastereomeric exc

28 logenation of 3-O-benzoyl-5,6-dideoxy-1, 2-O-isopropylidene-alpha-D-ribo-hex-5-enofuranose gave 6-hal

29 ed by Moffatt oxidation of 3-O-benzoyl-1,2-O-isopropylidene-alpha-D-ribo-hexofuranose (2c) with the d

30 5-O-acyl-4-C-acyloxymethyl-3-O-benzyl-1,2-O-isopropylidene-alpha-D-ribofuranose has been achieved in

31 ctions in 3-O-benzyl-4-C-hydroxymethyl-1,2-O-isopropylidene-alpha-d-ribofuranose has been achieved.

32 5-O-Benzyl-1, 2-O-isopropylidene-alpha-D-ribofuranose was prepared by an i

33 i-O-benzyl-3-O-alpha-D-glucopyranosyl-1, 2-O-isopropylidene-alpha-D-ribofuranose.

34 truct 4-[5-O-(tert-butyldimethylsilyl)-2,3-O-isopropylidene-alpha-d-ribofuranosy l]-6,7-dichloroquino

35 zed from commercially available 1,2:3,5-di-O-isopropylidene-alpha-D-threo-apiofuranose (7) by a very

36 was prepared by an improved route from 1,2-O-isopropylidene-alpha-D-xylofuranose and was coupled with

37 Therefore, the syntheses of poly(1,2-O-isopropylidene-alpha-d-xylofuranose monothiocarbonate)s

38 ening copolymerizations of 3,5-anhydro-1,2-O-isopropylidene-alpha-d-xylofuranose with carbonyl sulfid

39 a variety of protected glycals into 1,2-cis-isopropylidene-alpha-glycosides in good yield.

40 sion of glycals to the corresponding 1,2-cis-isopropylidene-alpha-glycosides.

41 f 2-trimethylsilyl thiazole to 5-deoxy-1,2-O-isopropylidene-alpha-L-erythro-pentofuran-3-ulose (2), w

42 n efficient route to methyl 3-O-benzyl-1,2-O-isopropylidene-alpha-l-idopyranosiduronate 6 from diacet

43 2,3-O-Carbonyl- and 2,3-O-isopropylidene-alpha-L-rhamnopyranosyl thioglycosides ar

44 (PCET) reactions and thermochemistry of 5,6-isopropylidene ascorbate (iAscH-) have been examined in

45 define the thermochemical landscape for 5,6-isopropylidene ascorbic acid and its derivatives in MeCN

46 onor 14 and 5-azido-3-O-benzyl-5-deoxy-1,2-O-isopropylidene-beta-d-fructopyranose (23) to form disacc

47 diate 18 which upon reaction with 3-(2',3'-O-isopropylidene-beta-D-ribofuranosyl)benzamide (19) gave,

48 Treatment of 3-(2,3-O-isopropylidene-beta-D-ribofuranosyl)benzamide (6) with P

49 matically monodeacetylated compound to 1,2-O-isopropylidene-C-4-spiro-oxetanoribofuranose.

50 Propylene and isopropylidene complexes (W(NAr)(ArNH(2))(OR(F9))(2)(pro

51 It is proposed that propylene and isopropylidene complexes interconvert through the format

52 atalyze the interconversion of propylene and isopropylidene complexes.

53 -deoxy-1-(4,5-d ichloro-2-nitrophenyl)-3,4-O-isopropylidene-d-allitol (8) as the major product.

54 5-dichloro-2-nitrophenyl)-1,2-dideo xy-3,4-O-isopropylidene-d-allo-1-enitol (5) as the basic skeleton

55 anhydro-6-O-(tert-butyldimethylsil yl)-3,4-O-isopropylidene-d-allose (11), which was subjected to the

56 The synthesis of d-noviose from 2,3-O-isopropylidene-d-erythronolactol is described.

57 ion of PhLi and lithiated dithianes to 2,3-O-isopropylidene-D-erythronolactone affords lactols, which

58 ergent approach from easily accessible 2,3-O-isopropylidene-d-erythrose (2b), and the combination of

59 anoside 8, which was prepared from the 2,3-O-isopropylidene-D-glyceraldehyde 1 in 13 steps.

60 ifluoropentan-2-ol 6 was prepared from 2,3-O-isopropylidene-d-glyceraldehyde 1, which was converted t

61 ate 4, which was readily prepared from 2,3-O-isopropylidene-D-glyceraldehyde in five steps.

62 yl nucleosides (1 and 2) starting from 2,3-O-isopropylidene-d-glyceraldehyde.

63 were synthesized starting with methyl 2,3-O-isopropylidene-d-glycerate (4) and D-ribo-phytosphingosi

64 Single carbon homologation of 1,2-O-isopropylidene-D-glycero-tetrafuranos-3-ulose (15) and o

65 and 32 which were prepared from 1,2:5,6-di-O-isopropylidene-D-mannitol and L-gulonic gamma-lactone, r

66 both been synthesized in 13 steps from di-O-isopropylidene-d-mannitol.

67 via an ester derived from (4R,5R)-(-)-2,3-O-isopropylidene-D-threitol at the 3-position, which was r

68 Selective trans-isopropylidene deprotection in coupled 13, then monobenz

69 se blocked as its 1"-beta- O-methyl-2",3"- O-isopropylidene derivative was evaluated.

70 al approach for the one-pot preparation of O-isopropylidene derivatives and also orthogonally protect

71 ucocorticoid agonists than the corresponding isopropylidene derivatives.

72 In contrast, photolysis of the cyclic isopropylidene diazomalonate (3), which also has a Z,Z-c

73 The isopropylidene fragment is appended in the endgame.

74 -ring was derived from readily available (R)-isopropylidene glyceraldehyde through a route featuring

75 ith HCl in MeOH achieves deprotection of the isopropylidene group and the N-benzyl group and conversi

76 ilon-CL) chains; (4) hydrolysis of the 1,2-O-isopropylidene group at the sugar core without any subst

77 oselectivity resulting from hindrance by the isopropylidene group favored addition at the beta face.

78 The selective opening of the isopropylidene group of 2 led to compound 3.

79 the alcohol 2, selective deprotection of the isopropylidene group of 3, followed by thermal eliminati

80 addition at the beta face (anti to the 1,2-O-isopropylidene group on the alpha face).

81 one-pot, acid-catalyzed reaction removed the isopropylidene group, promoted spirocyclization, constru

82 plus the acid-catalyzed isomerization of an isopropylidene group, provided a suitable pseudosugar pr

83 ediates the one-step transformation of alpha-isopropylidene ketones into furan rings following a biom

84 Moffatt oxidation of 2',3'-O-isopropylidene-L-adenosine and treatment of the resultin

85 ding 3-O- and 2-O-allyl derivatives of 5,6-O-isopropylidene-l-ascorbic acid, respectively, followed b

86 ntermediate 8, which was prepared from 2,3-O-isopropylidene-l-glyceraldehyde 1 in 13 steps, was conde

87 ur target compounds, was prepared from 1,2-O-isopropylidene-L-glyceraldehyde via (R)-2-fluorobutenoli

88 hylsulfonyl-6-O-p-methoxybenzyl-1,2:4,5-di-O-isopropylidene-myo-inositol 11.

89 s of (+/-)-6-O-p-methoxy-benzyl-1,2:4,5-di-O-isopropylidene-myo-inositol allowed the preparation of 1

90 s, namely mono- and diesters of 1,2:5,6-di-O-isopropylidene-myo-inositol and 1,2:5,6-di-O-cyclohexyli

91 s of the resolved 3-O-allyl-6-O-benzyl-1,2-O-isopropylidene-myo-inositol in a convergent synthesis.

92 bserved for 3,6-di-O-triisopropylsilyl-1,2-O-isopropylidene-myo-inositol.

93 he 5R configured enantiomer of racemic 1,2-O-isopropylidene-myo-inositols possessing chemically and s

94 The reagent N-isopropylidene-N'-2-nitrobenzenesulfonyl hydrazine (IPNB

95 A bis-trifluoromethyl-7-isopropylidene norbornadiene was not polymerized stereor

96 r the opportunity to synthesize propylene or isopropylidene olefin metathesis-active complexes in the

97 lactones possessing either a 16alpha,17alpha-isopropylidene or -butylidene group are described.

98 The competing reactivity of isopropylidene oxindoles (electrophilicity vs nucleophil

99 enantioselective spirocyclization reactions, isopropylidene oxindoles are the least explored to date.

100 Herein, we present the first ever use of 3-isopropylidene oxindoles as electrophiles in vinylogous

101 highly efficient and practical route to 3,4-isopropylidene proline I, starting from (+)-3-carene, wa

102 from C5-C6 cleavage); (2) glucose 1,2,5,6-di-isopropylidene propionate (m/z 301, no cleavage of gluco

103 amine, and isocyanide components related to isopropylidene-protected d-fructose, l-sorbose, d-galact

104 The resulting head piece, an enantiopure isopropylidene-protected glyceryl glycidyl ether diaster

105 acid catalyzed anomeric reduction of a 1,2-O-isopropylidene-protected glycofuranoside, and a Baeyer-V

106 tization using cesium carbonate gave rise to isopropylidene-protected hexasubstituted resorcylates.

107 onor, which was followed by coupling with an isopropylidene-protected Kdo-fluoride donor to afford a

108 straightforward, as ester, silyl ether, and isopropylidene protection failed to afford desired C-lin

109 en-membered sugar chain substituted with two isopropylidene rings.

110 stereospecific esterification of 1,2- or 2,3-isopropylidene-sn-glycerols by selected fatty acids is u

111 A broad range of isopropylidene substrates are accommodated, including en

112 reagents or Ruppert's reagent (TMS-CF(3)) to isopropylidene tartaric dichloride, is reported.

113 -O-isopropylidene-tartrate, d-dimethyl-2,3-O-isopropylidene-tartrate, and meso-erythritol, respective

114 xides were synthesized from l-dimethyl-2,3-O-isopropylidene-tartrate, d-dimethyl-2,3-O-isopropylidene

115 The oligoenes contain an isopropylidene unit at each end.