ライフサイエンスコーパス: isoquinoline

1 ine formation and reduction of the resulting isoquinoline.

2 ed a pentacene viz., 9H-indolo-pyrrolo[2,1-a]isoquinoline.

3 ing from the readily available 2,5-dimethoxy isoquinoline.

4 ecting group for the formation of N-PAHs via isoquinoline.

5 ermediates to transform them ultimately into isoquinoline.

6 solution-phase Pomeranz-Fritsch synthesis of isoquinoline.

7 -substituted derivatives of 1H-pyrrolo[3,2-c]isoquinoline.

8 s including indole, thiophene, pyridine, and isoquinoline.

9 aroyl-substituted imidazo-/benzimidazo-fused isoquinolines.

10 tandem synthesis of indolo and pyrrolo[2,1-a]isoquinolines.

11 nd ultimately to imidazo[4,5-c]pyridines and isoquinolines.

12 enation pathway to large-scale production of isoquinolines.

13 C4-quaternary centers from the corresponding isoquinolines.

14 incorporate a trifluoroethanol unit onto the isoquinolines.

15 ides has been developed for the synthesis of isoquinolines.

16 rylated functionalized dihydroquinolines and isoquinolines.

17 rrolo[3,2-c][1,2,4]triazolo[5,1-a] or [3,4-a]isoquinolines.

18 ble three component reactions among pyridine/isoquinoline 1/2, aryl diazoesters 3, and acrylic ester/

19 hyl-2, 1-ethanediyl)]-bis(5-nitro-1H-benz[de]isoquinoline-1,3(2H)-dione] dimethanesulfonate) is a nov

20 ent is introduced at the C-6 position of the isoquinoline-1,3(2H,4H)-dione core.

21 The series of 4-(phenylaminomethylene)isoquinoline-1,3(2H,4H)-dione derivatives reported here

22 the headpiece of the 4-(phenylaminomethylene)isoquinoline-1,3(2H,4H)-dione, a basic amine substituent

23 ethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3- diones with substituents at the 4, 8,

24 The series of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-dione and 4-[(pyridylmethyl)ami

25 )-dione and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-dione derivatives reported here

26 We report herein the discovery of isoquinoline-1,3-dione as a viable chemotype for selecti

27 ent is introduced at the C-6 position of the isoquinoline-1,3-dione core.

28 It is also shown that 2-hydroxy-4H-isoquinoline-1,3-dione--an inhibitor of ribonucleases th

29 w 2-[2'-(dimethylamino)ethyl]-3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at the 6- and

30 The copper isoquinoline-1-carboxylate salt was precipitated from th

31 Glycosyl isoquinoline-1-carboxylate was developed as a novel benc

32 C-phenyl ring, respectively, transform into isoquinoline-1-thiones and quinolin-4-ones under thermal

33 lly favorable mechanism for the formation of isoquinoline-1-thiones proceeds through a [1,5]-hydride

34 ,2,3,5,6alpha,10beta-hexahydropyrrol o[2,1-a]isoquinoline ((11)C-McN 5652) was the first PET radiotra

35 thesis of diversely substituted indolo[2,1-a]isoquinolines 11a-r, pyrrolo[2,1-a]isoquinolines 12a-d,

36 dro-6-[4-(methylthio)phenyl]pyrrolo-[2,1-a]- isoquinoline ([11C]McN 5652) is the first PET radioligan

37 olo[2,1-a]isoquinolines 11a-r, pyrrolo[2,1-a]isoquinolines 12a-d, and indolo-, pyrrolo[2,1-f][1,6]nap

38 d by benzo[a]quinolizine 8 and pyrrolo[2,1-a]isoquinoline 13, with an interest in stereochemistry and

39 lo[1,2-a]pyridines 7a-k and imidazolo[2, 1-a]isoquinolines 13a,b in good yields.

40 (methylenedioxy)-5,11-dioxo-11H-indeno[1,2-c]isoquinoline (13c) and 5,6-dihydro-6-(4-hydroxybut-1-yl)

41 irect synthesis of bisindolo-, pyrrolo[2,1-a]isoquinolines 15a-g, a regioisomer of the bisindolo[1,2-

42 m pyrolysis (FVP) of 1-(5-(13)C-5-tetrazolyl)isoquinoline 18 generates 1-((13)C-diazomethyl)isoquinol

43 oxy-2,3,4,6,7,11b-hex ahydro-1H-pyrido[2,1-a]isoquinoline ((18)F-AV-266), and (2S,3R,11bR)-9-(3-fluor

44 oquinoline 18 generates 1-((13)C-diazomethyl)isoquinoline 19 and 1-isoquinolyl-((13)C-carbene) 22, wh

45 9-methylenedioxy-5,11-dioxo-11H-indeno[1,2-c]isoquinoline (19a), did not unwind DNA and did not affec

46 cyclic 1,2,3,5,10,10a-hexahydroimidazo[1,5-b]isoquinolines 1a-c and 2,3,10,10a-tetrahydroimidazo[1,5-

47 Quinoline (1) and isoquinoline (2), upon activation by strong acids, lead

48 ly to a novel tricyclic 1,10a-dihydroimidazo-isoquinoline-2,5,10-trione scaffold, a structure that ha

49 the complex of hCA II with 4-(3,4-dihydro-1H-isoquinoline-2-carbonyl)benzenesulfonamide (3) (PDB code

50 usefulness of the 3-phenyl-4-(phenylselanyl)isoquinoline-2-oxide was demonstrated in the annulation

51 synthesis of 3-organyl-4-(organylchalcogenyl)isoquinoline-2-oxides via electrophilic cyclization betw

52 total of 21 3-organyl-4-(organylchalcogenyl)isoquinoline-2-oxides were selectively obtained in yield

53 les (5, 7, 10, 13), 5,6-dihydroindolo[2, 1-a]isoquinolines (20, 21), and 6,7-dihydro-5H-benzo[c]azepi

54 (methylenedioxy)-5,11-dioxo-11H-indeno[1,2-c]isoquinoline (21) and cis-6-allyl-5,6,12,13-tetrahydro-2

55 The 10-methoxy-5,6-dihydroindolo[2, 1-a]isoquinolines (21a-c) had higher binding affinities than

56 (methylenedioxy)-5,11-dioxo-11H-indeno[1,2-c]isoquinoline (22), both of which displayed submicromolar

57 yl)-5,6-dihydro-5, 11-dioxo-11H-indeno[1,2-c]isoquinoline (26) and 6-ethyl-2, 3-dimethoxy-8,9-(methyl

58 FVP of 3-(5-tetrazolyl)isoquinoline 28 similarly generates 3-diazomethylisoquin

59 d compounds 25 and 26, the 5,6-dihydrobenz[f]isoquinoline 28, and the benzofuro[3,2-c]pyridine 30.

60 simple straightforward syntheses of triazolo isoquinolines (3) and isochromenes (7) from 2-alkynylben

61 -(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide).

62 -methyl-N-(1-methylpropyl)-1-(2-chlorophenyl)isoquinoline-3-carboxamide)] or DPA-714 in excess.

63 methyl-N-(1-methylpropyl)-1-(2-chlorophenyl)-isoquinoline-3-carboxamide].

64 henyl)methyl-1,2,3,4,4a,5,6,7,8,8a-decahydro isoquinoline-3-carboxylic acid), which antagonizes kaina

65 Ketone-containing isoquinolines 36 and 49-51 have also been prepared by th

66 iated by (Ph(3)P)(2)NiCl(2)/Zn, afforded bis-isoquinolines 4.

67 droxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de] isoquinoline (4, dinapsoline).

68 oped for the synthesis of hexahydro-1H-spiro[isoquinoline-4,4'-pyran] derivatives through the condens

69 For example, the isoquinoline 49D1E2 has NFkappaB agonism with pIC50 of 8

70 ey intermediates in the synthesis are benz[g]isoquinoline-5,10-diones which are substituted at positi

71 l)thieno[2',3':5,6]pyrido[3,4-g]thieno[3,2-c]isoquinoline-5,11(4H, 10H)-dione) (PNTPD); poly(5-(4,10-

72 thieno[2',3':5',6']pyrido[3,4-g]thieno[3,2-c]isoquinoline-5,11(4H,10H)-dione and fluorenedicyclopenta

73 d 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36) (3) is among the fe

74 fore, NBS furnished direct conversion to the isoquinoline-5,8-dione; alternatively, N-haloimides of c

75 lyzed synthesis of oxazine/benzoxazine-fused isoquinolines 5a-q and naphthyridines 6a-v by the reacti

76 3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propyla mino}-propane bis(trifluoroaceta

77 9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinoline-7-one), both of which bind in the ATP-bindi

78 (23) and 8-hydroxy-1,2,3,4-tetrahydrobenz[h]isoquinoline (9)].

79 ion products, especially beta-carbolines and isoquinolines, act as neurotoxins that induce PD or enha

80 genative coupling of 5-benzoyl-pyrrolo[2,1-a]isoquinoline afforded 8H-indeno-pyrrolo[2,1-a]isoquinoli

81 Berberine, an isoquinoline alkaloid derived from a plant used traditio

82 Berberine (BBR) is an isoquinoline alkaloid from plants known to improve cardi

83 ans excrete a small but steady amount of the isoquinoline alkaloid morphine in their urine.

84 Berberine is an isoquinoline alkaloid used for its pharmacological funct

85 Emetine, a natural isoquinoline alkaloid with broad pharmacological potenti

86 As proof of concept, a fluorinated isoquinoline alkaloid, (18) F-aspergillitine is prepared

87 lecule pharmaceutical, a naturally occurring isoquinoline alkaloid, and endogenous compounds includin

88 berine (BER), a clinically important natural isoquinoline alkaloid, has gained increasing attention d

89 Berberine, an isoquinoline alkaloid, is a traditional oriental medicin

90 There is no doubt that a simple isoquinoline alkaloid, tetrahydropapaveroline (THP), is

91 hrome P450 genes (CYP28) from two species of isoquinoline alkaloid-resistant Drosophila and the cosmo

92 Hence, only that portion of the isoquinoline alkaloids excreted in urine unmetabolized c

93 The isoquinoline alkaloids isolated from the genus Corydalis

94 mizing oxidative rearrangements of prominent isoquinoline alkaloids Noscapine and Hydrastine.

95 ipecac alkaloids, a series of monoterpenoid-isoquinoline alkaloids such as emetine and cephaeline, w

96 he asymmetric synthesis of chiral nonracemic isoquinoline alkaloids, a family of natural products sho

97 Ethers undergo oxidant-free coupling with isoquinolines, alkenes, alkynes, pyrazoles, and purines

98 aromatic substitution reactions to make the isoquinoline allows direct access to analogues possessin

99 Here we report the discovery of several isoquinoline analogues, exemplified by 1 and 2, which bi

100 sentatives of 7H-imidazo[2,1-a]pyrrolo[3,2-c]isoquinoline and 1H-imidazo[2,1-a]pyrrolo[3,4-c]isoquino

101 Chiral acid chlorides were reacted with isoquinoline and 6,7-dimethoxy-3,4-dihydroisoquinoline t

102 A series of pyrrolo[2,1- a]isoquinoline and coumarin-fused pentacyclic derivatives

103 A Pomeranz-Fritsch synthesis of isoquinoline and Friedlander and Combes syntheses of sub

104 hod affords unprecedented fluorinated benz[f]isoquinoline and octahydroisoquinoline products in high

105 Multisubstituted isoquinoline and pyridine N-oxides have been prepared by

106 found to be optimum for activity in both the isoquinoline and quinazoline series.

107 Porphyrins with fused isoquinoline and quinoline units have been prepared by t

108 plex I inhibitors, including rotenone, MPP+, isoquinoline and tetrahydroisoquinoline, induce apoptosi

109 enantioselective synthesis of pyrrolo[2,1-a]isoquinolines and an attempted synthesis of the alkaloid

110 in targeting more embellished quinolines and isoquinolines and complex platforms embodying these moie

111 amino-functionalized benzo[4,5]imidazo[2,1-a]isoquinolines and isoquinolino[3,4-b]quinoxalines.

112 Monosubstituted isoquinolines and naphthyridines have been synthesized b

113 lenium-, and sulfur-containing disubstituted isoquinolines and naphthyridines, respectively.

114 Monosubstituted isoquinolines and pyridines have been prepared in good t

115 synthesis of 2'-substituted 2-aryl pyridines/isoquinolines and related heterobiaryls.

116 s provides a general approach to an array of isoquinolines and their corresponding N-oxides.

117 Various pyridine, quinoline, isoquinoline, and pyrimidine N-oxides were converted to

118 substituted pyridines, thiazoles, quinoline, isoquinolines, and pyrazine (1-9 and 28) has been studie

119 es, deazapurines, benzimidazole, quinolines, isoquinolines, and pyridines were efficiently deuterated

120 When exposed to UV light, the pyrrolo[2,1- a]isoquinoline- and coumarin-fused pentacycles B were foun

121 Various pyridine-, quinoline-, isoquinoline-, and pyrimidine-N-oxides were converted to

122 been developed from reactions of pyridine-, isoquinoline-, and quinoline ynones, via 5-exo-dig cycli

123 The indeno[1,2-c]isoquinolines are an important class of topoisomerase I

124 loped electron-deficient directing group and isoquinoline as a ligand.

125 h as quinoxalines, pyridines, quinoline, and isoquinoline as well as quinones.

126 rd hydroxymethylation of beta-carbolines and isoquinolines as effective directing groups has been dev

127 rolo[3,2-c][1,2,4]triazolo[5,1-a] and [3,4-a]isoquinolines, as well two more new heterocyclic systems

128 Pyridine, quinoline, isoquinoline, azaindole, and pyrimidine N-oxides were co

129 es an efficient access to 1,3-functionalized isoquinoline-based antitumor agent.

130 We previously reported an isoquinoline-based NRF2 activator, but this compound sho

131 Isoquinolines, benzoisoquinolines, thieno[3,2-c]pyridine

132 including the beta-carboline harmine and the isoquinoline berberine, that ameliorated certain aspects

133 ave investigated the gas-phase production of isoquinoline by performing collisional activation on ben

134 l substituents are better than alkyls at the isoquinoline C-1 position.

135 -chlorophenyl]-N-methyl-N-[1-methylpropyl]-3-isoquinoline carboxamide) ([(11)C](R)-PK11195).

136 -chlorophenyl]-N-methyl-N-[1-methylpropyl]-3-isoquinoline carboxamide)--a positron-emitting ligand th

137 -chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide).

138 2-chlorphenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline-carboxamide (PK11195) is a ligand specific

139 identified 1-(2-chlorophenylmethylpropyl)-3-isoquinoline-carboxamide (PK11195), a typical peripheral

140 c acid-6'-carboxylic acid, L = 4-picoline or isoquinoline) catalysts proceed through a single-site wa

141 A potent and highly selective isoquinoline CHK1 inhibitor (SAR-020106) was identified,

142 ction of the dearomatized, alkyl-substituted isoquinoline complexes is also reported.

143 gy provides a simple and convenient route to isoquinolines containing an aryl, alkyl, or vinylic grou

144 The 5-isoquinoline-containing compound 14a (hTRPV1 IC50 = 4 nM

145 developed in our laboratories to build a key isoquinoline-containing intermediate comprising the enti

146 oduction of substituents at the C1 carbon of isoquinoline core along with syntheses applying various

147 ing of the nitrogen-containing ring B of the isoquinoline core by the formation of bonds between C1-N

148 alyzed enolate arylation is used to form the isoquinoline core.

149 nes to a series of potent and CHK1-selective isoquinolines demonstrates how fragment-growing and scaf

150 aporphine cores through reactions between an isoquinoline derivative and silylaryl triflates promoted

151 To investigate the effectiveness of a novel isoquinoline derivative, EDL-155, in killing retinoblast

152 hat high quantum yields of the quinoline and isoquinoline derivatives are a result of the relative re

153 The photophysical properties of isoquinoline derivatives differ from those of quinolines

154 at room temperature gave 3-hydroxy-4-pyridyl-isoquinoline derivatives in good yields.

155 ization gave general access to pyrrolo[2,1-a]isoquinoline derivatives under very mild conditions.

156 sine receptors by a series of 3-(2-pyridinyl)isoquinoline derivatives was investigated by examining t

157 C(4) of the 2-azabuta-1,3-dienes, providing isoquinoline derivatives, can occur at elevated temperat

158 Several 3-(2-pyridinyl)isoquinoline derivatives, including VUF5455, VUF8502, VU

159 hlorides, including pyridine, quinoline, and isoquinoline derivatives.

160 tained for previously reported quinoline and isoquinoline derivatives.

161 ynes has been developed for the synthesis of isoquinoline derivatives.

162 trategy has been illustrated in synthesizing isoquinoline-derived natural products.

163 ual dual BDAC sequence leading to N-N-linked isoquinoline dimer.

164 nervous system regeneration to show that the isoquinoline drug praziquantel (PZQ) acts as a small mol

165 tic method to prepare partially hydrogenated isoquinolines efficiently from silver-mediated [3,3]-sig

166 tandem approach for annulated napthyridines/isoquinolines embedded with the phosphine oxide group un

167 a binding motif led to the identification of isoquinoline ethyl urea 13 as a promising starting point

168 2,2'-bipyridine-6,6'-dicarboxylate; isoq is isoquinoline) exists as the open-arm chelate, [Ru(II)(CO

169 When isoquinolines featuring a proton at the 4-position are u

170 (sp(2))-H functionalization of pyridines and isoquinolines for the synthesis of imidazo[1,2-a]pyridin

171 e triflate and a boronate ester, followed by isoquinoline formation and reduction of the resulting is

172 y (FBDD) effort in which we first identified isoquinoline fragments that disrupt TNFalpha ligand-rece

173 monium acetate, and a variety of substituted isoquinolines, furopyridines, and thienopyridines is pre

174 potency, they were ranked in the order of 5-isoquinoline > 8-quinoline = 8-quinazoline > 8-isoquinol

175 oquinoline > 8-quinoline = 8-quinazoline > 8-isoquinoline > or = cinnoline approximately phthalazine

176 ncluding N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H-89), adenosine 3'-5'cyclic monophosphoth

177 nhibitor N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H89) or the p38 mitogen-activated protein

178 nhibitor N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H89).

179 ocked by N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H89)] and extracellular signal-regulated k

180 N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H89; a protein kinase A inhibitor) stimula

181 method for the synthesis of tetrazolo[5,1-a]isoquinolines has been developed starting from alkenyl-1

182 lving trifluoroethanol radical reaction with isoquinolines has been proposed.

183 bility of this reaction for the synthesis of isoquinolines has been shown.

184 o, C6-CD(3)O substitution pattern of the P2* isoquinoline heterocycle of 21 was essential to securing

185 In addition, isoquinoline heterocycles have been prepared in excellen

186 A regioselective synthesis of furanone-fused isoquinoline heterocycles is developed in a single step

187 quinoline and 1H-imidazo[2,1-a]pyrrolo[3,4-c]isoquinoline heterocyclic skeletons, which were further

188 ctive synthesis of the hexahydroimidazo[1,5b]isoquinoline (HHII) scaffold as a surrogate for the ster

189 -activity relationship exploration around an isoquinoline hit, followed by an exploration of tolerate

190 imethoxy-8,9-methylenedioxy-11H-indeno[1,2-c]isoquinoline hydrochloride (14) is a strong topoisomeras

191 9-methylenedioxy-5,11-dioxo-11H-indeno[1,2-c]isoquinoline hydrochloride (19a), which proved to be a v

192 roxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline hydrochloride 6 and the resolution of its e

193 dimethoxy-(m ethylenedioxy)-11H-indeno[1,2-c]isoquinoline hydrochloride), the cytotoxicity of bisinde

194 to variously 5-substituted 3H-pyrrolo[2,3-c]isoquinolines in excellent yields.

195 trahydroisoquinolines into the corresponding isoquinolines in just three simple steps (yield 71.7% in

196 efficient route to substituted pyrrolo[1,2-b]isoquinolines in moderate to good yields (up to 94%, 22

197 or the assembly of imidazo/benzimidazo[2,1-a]isoquinolines in moderate to good yields.

198 al-free strategy for the synthesis of 3-keto-isoquinolines in one pot has been developed from the eas

199 particular, prenol lipids, isoflavonoids and isoquinolines in superfoods, when compared with non-supe

200 s transformation to furnish a variety 3-keto-isoquinolines in very good yields.

201 rolo[3,4-c][1,2,4]triazolo[5,1-a] and [3,4-a]isoquinolines, in good yields without triazole ring clea

202 fluorenones and fluorenones containing fused isoquinoline, indole, pyrrole, thiophene, benzothiophene

203 We have tested whether these isoquinolines inhibit P2X receptor function in human emb

204 gression of a potent and selective series of isoquinoline inhibitors of IkappaB kinase-beta (IKK-beta

205 itivity to the rat P2X7R; this suggests that isoquinolines interact with residues in the amino-termin

206 isomeric pyrrolo[3,2-c][1,2,4]triazolo[3,4-a]isoquinolines involves, besides the triazole ring openin

207 e a novel "one-pot" process to assemble aryl(isoquinoline)iodonium salts in 40-94 % yields from mesoi

208 Isoquinolines (IQs) and their derivatives are present in

209 nantioselective synthesis of an indoline and isoquinolines is also demonstrated.

210 leophiles to N-acyl activated quinolines and isoquinolines is described.

211 sisted one-pot reaction for the synthesis of isoquinolines is developed.

212 -2,3,3a,4,5,6,9b-hexahydro-1H-pyrrolo-[3,2h]-isoquinoline) is a conformationally restricted analog of

213 and L = pyridine (py), trimethylamine (tma), isoquinoline (isoq), 4-dimethylaminopyridine (dmap), and

214 effect was inhibited by oxidized ATP and the isoquinoline KN-62, two known P2X7 receptor antagonists.

215 m, cyclization of each olefin afforded fused isoquinoline lactams as single diastereomers epimeric at

216 -TsOH, cyclization occurred to produce fused isoquinoline lactams by a mechanism that involves an ini

217 The unique impact of the isoquinoline ligand underscores the importance of subtle

218 nd involving the ring nitrogen-2 atom of the isoquinoline must be preserved, but that the ring can fl

219 Atropisomeric biaryl pyridine and isoquinoline N-oxides were synthesized enantioselectivel

220 The total synthesis of the isoquinoline natural product decumbenine B has been acco

221 s the key step in a concise synthesis of the isoquinoline natural product illudinine.

222 ontacts between the extended enolate and the isoquinoline of the catalyst.

223 nzyl group on compounds containing either an isoquinoline or indazole heterocyclic core.

224 onverted into aminoallenylidene isochromans, isoquinolines, or tetrahydronaphtalenes with silver(I) s

225 however, a new, readily available bidentate isoquinoline-oxazoline ligand furnishes excellent ee's a

226 ed to get access to novel spiropyrrolo[1,2-a]isoquinoline-oxindole skeletons by a one-pot three-compo

227 tion of monohydroxymethylated beta-carboline/isoquinoline products exclusively.

228 I) intermediate, improving the yields of the isoquinoline products.

229 e, tetrahydroisoquinoline, 5,6-dihydrobenz[f]isoquinoline, pyrindine, and pyridine heterocycles have

230 boronate functionalized heterocycles such as isoquinoline, pyrrole, and indole.

231 uran, and norbornenes with a variety of aryl isoquinoline, quinazoline, and picoline derivatives take

232 Transition metal-free acylation of isoquinoline, quinoline, and quinoxaline derivatives has

233 successfully used for this reaction, such as isoquinolines, quinoline, phenanthridine, quinazoline, p

234 g between electron-deficient N-heterocycles (isoquinoline, quinolines, and quinoxalines) and methylbe

235 are novel but poorly characterized cytotoxic isoquinoline quinones and iminoquinones identified in ex

236 hy l-5,6,7,8-tetrahydro-[1,3]-di-oxolo[4,5-g]isoquinoline (Red-Br-nos), exerts a novel autophagic res

237 the C-3 and C-4 position for quinolines and isoquinolines respectively, providing access to substitu

238 isubstituted indenones and 1,3-disubstituted isoquinolines, respectively.

239 lacement of the nucleophilic co-catalyst for isoquinoline resulted in a divergent reaction pathway an

240 reparation of a wide range of (18) F-labeled isoquinolines resulting in up to 92 % radiochemical conv

241 e-activity relationship between the nitrated isoquinoline ring and a methylenedioxy-substituted inden

242 the protonated and unprotonated forms of the isoquinoline ring of papaverine were identified.

243 bromo, nitro, acetyl, and aminomethyl on the isoquinoline ring resulted in a significant loss of acti

244 ubsite of the inhibitor which identified the isoquinoline ring system as a key template for improving

245 in the 2H-bis([1,2,3]triazolo)[5,1-a:4',5'-c]isoquinoline ring system is elaborated using a simple sy

246 A methoxy moiety at the C6 position of this isoquinoline ring system proved to be optimal with respe

247 ses pointed to a proton at position-9 of the isoquinoline ring that can be modified without compromis

248 austive series was prepared using a nitrated isoquinoline ring that has been previously demonstrated

249 epared utilizing a 2,3-dimethoxy-substituted isoquinoline ring.

250 s significantly enhanced by nitration of the isoquinoline ring.

251 roup at C-3 and an aroyl group at C-4 of the isoquinoline ring.

252 rophobic contacts and the hydrogen bond with isoquinoline ring.

253 rs to be similar to coclaurine NMT, with the isoquinoline rings buried deepest in the binding pocket.

254 he benzyl ring is bound more deeply than the isoquinoline rings.

255 rwent oxidative coupling to form the desired isoquinoline salts and regenerate [Cp*MCl2]2.

256 Moreover, it was possible to synthesize the isoquinoline salts from readily available starting mater

257 Bi-, tri-, and tetracyclic isoquinoline salts were readily synthesized in excellent

258 1,2,3,4-tetrahydro-beta-carboline (THBC) and isoquinoline scaffolds found in many important pharmaceu

259 elevant heterocycles such as pyrimidines and isoquinolines showcases on a large set of derivatives, i

260 The 7-hydroxy group of the isoquinoline skeleton of the aglycon is methylated by Ip

261 g H89 (N-[2-(p-bromo-cinnamylamino)-ethyl]-5-isoquinoline-sulfon-amide 2HCl) and Ht31, disruptors of

262 d H89 (N-[2-(p-bromo-cinnamylamino)-ethyl]-5-isoquinoline-sulfon-amide 2HCl), as well as by the AKAP

263 A large family of isoquinoline sulfonamide compounds inhibits protein kina

264 n signals was inferred from experiments with isoquinoline sulfonamide protein kinase inhibitors.

265 G (PKG) inhibitor N-[2-(methylamino)ethy]-5-isoquinoline-sulfonamide (H8) blocks NECA, hydroxylamine

266 fully blocked by N-[2-(methylamino)ethyl]-5'-isoquinoline-sulfonamide and 2-[1-(3-dimethylaminopropyl

267 Rhodobacter sphaeroides (10 microg/ml); the isoquinoline-sulfonamide H-8 (10 and 100 microM), which

268 n kinase, N-[2(p-bromocinnamylamino)ethyl]-5-isoquinoline-sulfonamide hydrochloride (H-89) and myrist

269 inase A inhibitor N-(2-(methylamino)ethyl)-5-isoquinoline-sulfonamide.

270 The ability of isoquinoline sulfonamides to potently inhibit human and

271 The PKC inhibitor 1-(5-isoquinoline sulfonyl)-2-methylpiperazine-HCl eliminated

272 ,5,12,12a alpha-octahydroquinolino-[2,3,3-g]-isoquinoline; TAN67) were coadministered in GH(3)MORDOR

273 A wide variety of substituted isoquinoline, tetrahydroisoquinoline, 5,6-dihydrobenz[f]

274 Within the 6,6-series, isoquinoline, tetralin, tetralone, and benzopyran nuclei

275 synthesis of new highly emissive tetracyclic isoquinolines that target specific organelles is describ

276 Among the syntheses of isoquinolines, the transition metal-free method describe

277 se complexes reacted with 2,2'-bipyridine or isoquinoline, they facilitated the alkyl migration of th

278 oxylate derivatives to give pyrano[2,3,4- ij]isoquinolines through a [4 + 2]-cycloaddition reaction.

279 The formation of a substituted isoquinoline using benzyl cyanide as the second nitrile

280 n of the trans diastereomers to indeno[1,2-c]isoquinolines using selenoxide elimination and Friedel-C

281 he trans products do not afford indeno[1,2-c]isoquinolines using this method.

282 complexes react with acylated quinolines and isoquinolines via 1,2-metalate rearrangement to give alk

283 A convenient method for preparing 3-aryl isoquinolines via a base-promoted tandem reaction is pre

284 eral applicability to diverse quinolines and isoquinolines via a tactic that utilizes the recursive a

285 h to regioselectively synthesize substituted isoquinolines via coupling with aryloxime esters.

286 luorescence quenching studies suggested that isoquinoline was responsible for the quenching of Ir-pho

287 A second small isoquinoline was subsequently shown to bind in a single

288 , a library of 19 selenium-decorated N-oxide isoquinolines was accessed in up to 96% yield with an ou

289 ighly functionalized 5,6-dihydroindolo[2,1-a]isoquinolines was developed via a pseudo four-component

290 Imidazo[1,2-a]pyrazine and imidazo[2,1-a]isoquinoline were also obtained in good yields under sim

291 lly, the synthesized 5,6-dihydroindolo[2,1-a]isoquinolines were examined for their photophysical prop

292 d pyridines and single isomer formation with isoquinolines were observed.

293 This powerful route to polysubstituted isoquinolines, which is not limited to electron rich moi

294 inopyridines, 2-aminopyrimidine, indole, and isoquinoline with moderate to excellent yields.

295 A convergent route to pyrrolo[1,2-b]isoquinolines with a quaternary center at C-10 has been

296 es a valuable new route to 3,4-disubstituted isoquinolines with aryl, allylic, benzylic, 1-alkynyl, a

297 yl amides, and thus obtain the corresponding isoquinolines with high enantiomeric ratios.

298 cts can be readily converted to indeno[1,2-c]isoquinolines with thionyl chloride, the trans products

299 zo[1,2-a]pyridines and 2-phenylimidazo[2,1-a]isoquinolines with vinyl azides under mild aerobic condi

300 -methyle nedioxy-5,11-dioxo-11H-indeno[1,2-c]isoquinoline) with both similarities and differences fro