ライフサイエンスコーパス: isotopomer

1 sotopomer that shifts to 580.2794 in the 18O-isotopomer.

2 es C, indicating no isomerization to another isotopomer.

3 , which shifts to 672 cm(-1) in the Mn-(18)O isotopomer.

4 as determined for the Tc((16)O)(3)((17)O)(-) isotopomer.

5 is-3-3,4-d(2)) in 64% yield as the exclusive isotopomer.

6 of amino acids containing a pure (13)CHD(2) isotopomer.

7 topomer, and a zero-(2)H-exchanged/two-(13)C isotopomer.

8 ative amount of labelling in a predetermined isotopomer.

9 bly selective, affording only the axial-d(1) isotopomers.

10 ere obtained from the results with the three isotopomers.

11 lcohol and its benzylic mono- and dideuterio isotopomers.

12 n is that between the d3-methyl enantiomeric isotopomers.

13 aterial and to determine abundances of these isotopomers.

14 e (5'S)-[5'-(2)H(1)]- and (5'R)-[5'-(2)H(1)]-isotopomers.

15 ponding spectra of the mu-O(2)(13)C(13)CO(2) isotopomers.

16 ulations of (13)CHD(2) and (13)CH(2)D methyl isotopomers.

17 to the distinct spectroscopic signatures of isotopomers.

18 tivity of enzymes for the heavier or lighter isotopomers.

19 the position specific labeling of subsets of isotopomers.

20 arrageenan gels and the prochiral and chiral isotopomers.

21 tains experimental MS/MS data on hundreds of isotopomers.

22 l peak magnitudes of the deuterium-exchanged isotopomers.

23 g mixtures of iCB[6] and its (13)C=O labeled isotopomer (13)C(12)-iCB[6].

24 , (190)Os, and (188)Os) and three unique 13C isotopomers (13C in ethylene, axial, and equatorial posi

25 The isotopomers [15N3]-2'-deoxycytidine and (methyl-d3,ring-

26 red rotational constants for the main osmium isotopomer ((192)Os) are A = 929.3256(6), B = 755.1707(3

27 (both isotopomers, ca. 100%) and C12 (minor isotopomer, 30-35%), that is, an approximately 2:1 mixtu

28 owed observation of transitions for the four isotopomers (63)Cu(12)C(14)N, (65)Cu(12)C(14)N, (63)Cu(1

29 entadiyne (6a), along with both monodeuterio isotopomers 6b and 6c, has been synthesized via a route

30 , an A + 2 peak is comprised of (among other isotopomers) a two-(2)H-exchanged/zero-(13)C isotopomer,

31 isotopomers) a two-(2)H-exchanged/zero-(13)C isotopomer, a one-(2)H-exchanged/one-(13)C isotopomer, a

32 lent agreement between measured and expected isotopomer abundances for the different NMR experiments,

33 asuring protein kinetics by quantifying mass isotopomer abundances of mid-sized peptides from protein

34 pectrometric methods to those extracts, mass isotopomer abundances of seven major organic acids were

35 sotope ratios (i.e., less dependence of mass isotopomer abundances on the amount of material injected

36 Mass isotopomer abundances were determined by electrospray io

37 a labeling data set consisting of 155 (13)C isotopomer abundances.

38 ine residues with specific (13)CHD(2) methyl isotopomers against a deuterated background.

39 The data suggest that combining (13)C isotopomer analyses and dynamic hyperpolarized (13)C spe

40 troscopy of tissue extracts and steady-state isotopomer analyses.

41 using a combination of metabolomics and mass isotopomer analyses.

42 with 13C-labeled substrates using 13C/1H-NMR isotopomer analysis after 30 minutes of low-flow ischemi

43 Both isotopomer analysis and activity assays suggest that cit

44 es of the 3 pathways were identified by mass isotopomer analysis and metabolomics.

45 (13)C-Isotopomer analysis and tandem mass spectrometry measure

46 A parallel ex vivo (13)C NMR isotopomer analysis following steady-state infusion of [

47 of the combination of metabolomics and mass isotopomer analysis for pathway discovery.

48 Mass spectrometric (MS) isotopomer analysis has become a standard tool for inves

49 sitive mass spectrometry techniques for mass isotopomer analysis has extended the reach of metabolic

50 QCLAS enables high-precision N(2)O isotopomer analysis in real time.

51 used to convert relative rates derived from isotopomer analysis into quantitative fluxes.

52 This mass isotopomer analysis is referred to as time and relative

53 Mass isotopomer analysis of C(4) and C(5) ketone bodies and o

54 A 13C isotopomer analysis of glutamate isolated from these cel

55 enome annotation and the transcript profile, isotopomer analysis of key metabolites clarifies ambigui

56 ucted a study coupling metabolomics and mass isotopomer analysis of liver gluconeogenesis and citric

57 Isotopomer analysis of liver glutamate confirmed that an

58 A steady-state (13)C-NMR isotopomer analysis of tissue extracts confirmed that fl

59 the use of J-resolved HSQC (J-HSQC) for 13C isotopomer analysis of tissue samples.

60 erpolarized (13)C NMR spectroscopy and (13)C isotopomer analysis provides quantitative insights into

61 bolites were then extracted and subjected to isotopomer analysis to determine relative rates of pathw

62 To examine this question, we applied 13C-isotopomer analysis to quantify flux through three anapl

63 ere, we combined (13)C hyperpolarization and isotopomer analysis to quantify multiple fates of pyruva

64 of 13C NMR spectroscopy makes application of isotopomer analysis to small tissue samples (mouse tissu

65 Here we used stable isotope labeling and isotopomer analysis to trace sterol flux through the two

66 Using mass isotopomer analysis we determined the enrichments of ace

67 ability, and accuracy of this method for the isotopomer analysis were validated.

68 inated from deacetylated APAP), through mass isotopomer analysis, accurate mass measurement, tandem m

69 of genetically modified animal models, mass isotopomer analysis, and metabolomics provides a powerfu

70 strate that FT-ICR MS is a powerful tool for isotopomer analysis, overcoming the problems with both G

71 Using (13)C isotopomer analysis, we show that BDQ-treated Mtb redire

72 od of numerical bias estimation regarding MS isotopomer analysis.

73 using a combination of metabolomics and mass isotopomer analysis.

74 Measuring the kinetics of lactate isotopomer and HDO production by (1)H and (2)H MR respec

75 MR method to measure the kinetics of lactate isotopomer and HDO production using a deuterated tracer.

76 1)H and (13)C relaxation rates of (13)CHD(2) isotopomers and (2)H (D) relaxation rates of (13)CH(2)D

77 eport separation of isotopic ions, including isotopomers and isobars, using ion mobility spectrometry

78 leucine and glucose for both highly enriched isotopomers and labeled isotopomers present in low abund

79 The isotopomers and their 50:50 mixtures formed helical dime

80 e isotopes but is blind to isotopic isomers (isotopomers) and, except at very high resolution, specie

81 C isotopomer, a one-(2)H-exchanged/one-(13)C isotopomer, and a zero-(2)H-exchanged/two-(13)C isotopom

82 verse datasets including genomic, proteomic, isotopomer, and DNA sequence variation are becoming avai

83 to detect 5-methyl-2'-deoxycytidine and its isotopomer, and ions of m/z 112 and 115 were used to det

84 Model reactions gave (16)O and (18)O isotopomers, and base-promoted hydrolysis of an O(2),2'-

85 uterated media, invariably all possible (2)H isotopomers are obtained.

86 g cytidylyl-(3',5')-cytidine phosphoramidite isotopomers as the common synthetic intermediates, with

87 rate) was measured competitively for various isotopomers at 103 degrees C.

88 C labeling of proteinogenic amino acids, and isotopomer balancing all indicated a large increase in t

89 paration is difficult and a major hurdle for isotopomer-based flux analysis of mixed cultures.

90 This study provides the foundation to extend isotopomer-based flux analysis to study metabolism of in

91 Isotopomer-based flux analysis typically relies on hydro

92 ild-type (WT) and PGC-1alpha(-/-) mice using isotopomer-based NMR with complementary gene expression

93 on accurate and precise measurements of mass isotopomers by gas chromatography/mass spectrometry.

94 frared absorption spectra of five deuterated isotopomers, C(6)D(5), p-C(6)H(4)D, p-C(6)HD(4), o-C(6)H

95 tions (patchoulol numbering system) C5 (both isotopomers, ca. 100%) and C12 (minor isotopomer, 30-35%

96 Besides, we show that (2)H-(13)C enantio-isotopomers can be distinguished using 2D NMR in chiral

97 While such isotopomers can be obtained in proteins overexpressed in

98 Furthermore, (14)N(2) and (15)N(2) isotopomers can be obtained, emphasizing a key trans-imi

99 s of [PO(3)](-)/or [H(2)PO(4)](-) ions, mass isotopomers can be quantified directly from the intensit

100 The MS/MS spectra of additional isotopomers can then be computationally generated and in

101 Given that isobaric isotopomers cannot be separated chromatographically or b

102 Spectra of [2-(13)C] and [3-(13)C] isotopomers contained signals arising from labeled carbo

103 ISA uses all mass isotopomers, correctly identified imposed gradients of p

104 zene, where H-/D-isotopic labelling finds no isotopomer cross-over and the non-reactivity of a nitren

105 Powerful modeling frameworks balancing 'isotopomers', 'cumomers', or 'elementary modeling units'

106 ay upon use of a perdeuteromethyl TMG(3)tren isotopomer, d(36)-1 (KIE = 24 at 25 degrees C).

107 evaluate the accuracy and precision of mass isotopomer data for each fragment.

108 umor metabolic fluxes from (13)C NMR kinetic isotopomer data has been developed and validated with pe

109 a novel LC-MS/MS workflow, acquisition, and isotopomer deconvolution method for MFA that takes advan

110 Previous experiments with GTP isotopomers demonstrated that the ribose C3' hydrogen at

111 In vivo metabolism of (13)C-labeled glucose isotopomers demonstrates that C-3-C-6 of glucose become

112 ll result in a combinatorial distribution of isotopomers depending on the enrichment and number of "l

113 Notably, such isotopomers differ slightly in mass as a result of the a

114 irst experimental observation of (14)N/(15)N isotopomers directly creating an asymmetric carbon.

115 mass isotopomer distribution analysis (MIDA) and isotopomer s

116 agreed closely with models obtained by mass isotopomer distribution analysis (MIDA) and were consist

117 The use of mass isotopomer distribution analysis (MIDA) to quantify plas

118 Mass isotopomer distribution analysis allows measurement of t

119 hesis rates compared to peptide centric mass isotopomer distribution analysis approaches when labelin

120 Mass isotopomer distribution analysis was used to measure the

121 nfusion of [1-(13)C] sodium acetate and mass isotopomer distribution analysis.

122 c tools were used to analyze changes in mass isotopomer distribution and changes in glucose and gluta

123 each metabolite pool by determining the mass isotopomer distribution for all labeled compounds.

124 ionization to rapidly measure the amino acid isotopomer distribution in a biomass hydrolysate of the

125 rate to an organism and then determining the isotopomer distribution in amino acids in proteins.

126 sotopoic enrichment due to their low natural isotopomer distribution in negative chemical ionization

127 es not affect E. coli growth kinetics or the isotopomer distribution in nine key metabolites.

128 n of (15)N amino acids results in a new mass isotopomer distribution in protein, which is approximate

129 ound by MS, for which high accuracy mass and isotopomer distribution measurements are critical.

130 he uptake of the acetate tracer and the mass isotopomer distribution of acetyl-CoA.

131 ngle highly expressed protein to analyze the isotopomer distribution of amino acids from one organism

132 beling measurements to quantify the complete isotopomer distribution of aspartate by least-squares re

133 thod for determining the complete positional isotopomer distribution of aspartate carbon atoms by gas

134 The mass isotopomer distribution of intermediates reveals the rev

135 or [5-(13)C]glutamine and analyzed the mass isotopomer distribution of key metabolites using models

136 lyl derivatization, and analysis of the mass isotopomer distribution of malonate.

137 ometry assays for the concentration and mass isotopomer distribution of malonyl-CoA in tissues.

138 The mass isotopomer distribution of malonyl-CoA was compared with

139 two companion articles, we compare the mass isotopomer distribution of metabolites of liver gluconeo

140 The isotopomer distribution of peptides after labeling can b

141 ometry assays for the concentration and mass isotopomer distribution of propionyl-CoA, methylmalonyl-

142 d EryI), a pathway fully consistent with the isotopomer distribution of the erythrose-4-phosphate-der

143 of key metabolites using models that fit the isotopomer distribution to fluxes.

144 The accurate determination of mass isotopomer distributions (MID) is of great significance

145 pe labeling experiments and analysis of mass isotopomer distributions (MID) of cellular metabolites i

146 based on the combinatorial analyses of mass isotopomer distributions (MIDs) of fatty acids and stero

147 scan types that maximizes the number of mass isotopomer distributions (MIDs) that can be acquired in

148 intracellular intermediate and cofactor mass isotopomer distributions (MIDs),1 it was found that a to

149 imulations, it was observed that carbon mass isotopomer distributions and measurement noise can be de

150 Metabolite profiles and their isotopomer distributions can be studied noninvasively in

151 cids but higher signal for nucleotides, mass isotopomer distributions from sorted cells were generall

152 without any fitting parameters, of the mass isotopomer distributions of fatty acids from cells grown

153 The mass isotopomer distributions of propionyl-CoA, methylmalonyl

154 o demonstrate this method, we determined the isotopomer distributions of samples of 13C-labeled leuci

155 At each step, the mass isotopomer distributions of the samples were analyzed by

156 ver, commonly used techniques to measure the isotopomer distributions require derivatization prior to

157 Mass isotopomer distributions were quantified precisely by LC

158 or inorganic phosphate and altered phosphate isotopomer distributions, consistent with increased phos

159 termined by least-squares regression of mass isotopomer distributions.

160 ctional lipogenesis calculated from the mass isotopomer distributions.

161 bined information is then utilized to derive isotopomer distributions.

162 cribed to differential H-bonding for the two isotopomers due to zero point energy differences.

163 equations that describe the dynamics of mass isotopomers during metabolic labeling with an atom-based

164 uncertainty estimation have progressed, mass isotopomer dynamics during label incorporation has only

165 ed an accurate GC/MS measurement for the low isotopomer enrichment assay of formic acid, acetic acid,

166 cidence measurements carried out on methanol isotopomers, ethylene glycol, and acetone.

167 2) shows rapid formation of all of the other isotopomers except 1.

168 stribution and available experimental (e.g., isotopomer) flux data.

169 imulated the expected abundance at each mass isotopomer for the GSNEM ion at various values for N, wa

170 of ATP hydrolyzed and the sum of new acetone isotopomers formed.

171 asured and allowed the identification of all isotopomers formed.

172 h precision for isotopologue and tandem mass isotopomer fractions representing >10% of total abundanc

173 e identification of isotopologues as well as isotopomers from biological samples and provides a platf

174 Spectroscopic data for triplet isotopomers H-C-C-C-H, H-(13)C-C-C-H, and H-C-(13)C-C-H

175 oron quadrupole coupling strengths for three isotopomers, H(6)C(4)(11)B(14)N, H(6)C(4)(10)B(14)N, and

176 thods; data for the deuterium and barium 137 isotopomers have been measured as well.

177 is- and trans-ethylene-d2 generates 1-hexene isotopomers having terminal CDH groups, with an isotope

178 ture of Iodoacetyl Tandem Mass Tag (iodoTMT) isotopomers (i.e., each having the same exact mass, but

179 e method accurately and precisely determined isotopomer identity and abundance in the labeled materia

180 ction of the pentose cycle on the M2 glucose isotopomer in the liver.

181 Measurement of the distribution of isotopomers in a labeled compound or mixture of labeled

182 ed and (13)C=(18)O-Leu/(15)N-Gly bis-labeled isotopomers in CDCl(3).

183 users to combine MS/MS spectra from various isotopomers in different ratios to obtain a theoretical

184 mulation of the steady state distribution of isotopomers in intermediates of the glycolysis/OPPP netw

185 provides a new means of quantifying glucose isotopomers in metabolic studies.

186 The distribution of sterol isotopomers in plasma mirrored that of liver.

187 Enrichments of M(+1) and M(+2) mass isotopomers in the CK-peptide were measurable but low (c

188 me as the integrated intensity of all of the isotopomers in the isotope distribution.

189 atorial analysis of the distribution of mass isotopomers in triacylglyceride glycerol.

190 This approach enables rapid generation of isotopomers in which carbon and hydrogen can be replaced

191 etection of (2)H-(13)C isotopomeric isomers (isotopomers) in natural abundance (1.7 x 10(-4)%) both i

192 Increased T(1) of (2)H-lactate isotopomers indicates inversion/saturation recovery meth

193 via indirect detection of 13C providing that isotopomer information can be preserved.

194 tabolite coverage, while also providing rich isotopomer information for a significant number of key m

195 biotechnological samples, while tandem mass isotopomer information is also accessible for a large nu

196 HOD in the jet reveal the formation of only isotopomers involving deuterium in the secondary hydroge

197 ng that the molecular orientation of glycine isotopomers is the same.

198 In addition, the distribution of mass isotopomers is used to study the biosynthesis of diacylg

199 D exchange using D2, and that five different isotopomers/isotopologues of the sigma-alkane complex re

200 IV)(CH(3))(2)D (1-d(1)()) with its scrambled isotopomer, kappa(3)-Tp(Me)2Pt(IV)(CH(3))(CH(2)D)H (1-d(

201 Methyldiazene (HN=N-CH3) isotopomers labeled with 15N at the terminal or internal

202 Further, the isotopomer labeling patterns of amino acids derived from

203 A novel MS/MS-based analysis strategy using isotopomer labels, referred to as "tandem mass tags" (TM

204 of maps to be automatically translated into isotopomer mass-balance equations.

205 fluxes that are typically computed from mass isotopomer measurements is increased.

206 Approximately 1,400 independent mass isotopomer measurements obtained from analysis of 37 met

207 methodology for flux determination from mass isotopomer measurements of biomass hydrolysates, while t

208 The two-isotopomer method did not identify gradients of precurso

209 the samples were analyzed by ISA and the two-isotopomer method to determine whether each method could

210 , did not agree with a simpler algebraic two-isotopomer method.

211 sulin secretion, we have adapted 13C NMR and isotopomer methods to measure influx of metabolic fuels

212 r-specific peak broadening due to unresolved isotopomer mixtures.

213 Isotopomer network compartmental analysis (INCA) is the

214 d myc(-/-) and myc(+/+) fibroblasts by (13)C isotopomer NMR analysis.

215 Here, we show that a positional isotopomer NMR tracer analysis (PINTA) method can be use

216 l oxidation in humans, we applied positional isotopomer NMR tracer analysis (PINTA) to assess rates o

217 eir regulators in humans by using positional isotopomer NMR tracer analysis.

218 A doublet peak pattern for the (16)O(18)O isotopomer of 2 in mixed-isotope Raman experiments stron

219 s monitored by the appearance of a plasma M1 isotopomer of glucose, which is produced by the action o

220 Using an isotopomer of tyrosine to evaluate artifactual productio

221 IE) for the interconversion of the two chair isotopomers of 1-trideutero-1,3,3-trimethylcyclohexane w

222 titative evaluation of 13C distribution into isotopomers of 13C-labeled aldoses and ketoses, and the

223 Trapable yields for three isotopomers of 2 range from 72% to 86%.

224 h the use of singly and doubly (13)C-labeled isotopomers of 2.

225 The microwave spectra of 10 isotopomers of 8 and 5 isotopomers of 9 were obtained us

226 crowave spectra of 10 isotopomers of 8 and 5 isotopomers of 9 were obtained using a pulsed nozzle Fou

227 atom fragmentations to fully resolve all 16 isotopomers of aspartate.

228 ly labeled with nondeuterated and deuterated isotopomers of CPM, respectively.

229 insic spectra and relative abundances of all isotopomers of ergosterol whose carbon atoms in the 5,7-

230 A series of 24 isotopologues and isotopomers of five organic compounds are separated, ide

231 articular, metabolic flux analysis uses mass isotopomers of metabolic products typically formed from

232 In order to elucidate positional isotopomers of nucleosides from RNA and DNA, we screened

233 technical limitations, we failed to separate isotopomers of phosphorylated sugars.

234 Our results establish that isotopomers of plant archives contain metabolic informat

235 laser spectra have been compiled for several isotopomers of small (dimer through hexamer) water clust

236 Rotational spectra of seven isotopomers of tetracarbonylethyleneosmium, Os(CO)4(eta2

237 R data are reported for the (15)N and (64)Ni isotopomers of the cofactor, both in the intact enzyme a

238 Several isotopomers of the complex were generated, and the IR sp

239 Isotopomers of the ribosomal P-site substrate, the trinu

240 developed protocol is suited to measure mass isotopomers of these alpha-keto acids in tracer studies

241 C]glucose to [(13)C]acetyl-CoA and M2 and M4 isotopomers of tricarboxylic acid (TCA) cycle intermedia

242 nitio procedure is demonstrated for the main isotopomers of water.

243 amolecular deuterium distribution (deuterium isotopomers) of photosynthetic C3 glucose contains a sig

244 H- and (13)C-substituted 2-deoxyribofuranose isotopomer on which to investigate this potential effect

245 ion of perhydrido and perdeutero cycloalkane isotopomers on the hexagonally close-packed Ru(001) and

246 ion framework for designing a set of protein isotopomers, or labeling schedules, to reduce the conges

247 the single carbon source, in order that the isotopomer pattern of all metabolites would mirror the l

248 calculated by combinatorial analysis of mass isotopomer patterns in peptides correlate very closely w

249 The isotopomer patterns of proteinogenic amino acids reveale

250 ass spectrometry (LC-MS/MS) analysis of mass isotopomer patterns to measure protein turnover.

251 matic errors unique for each individual mass isotopomer peak.

252 brated back to the imide A-py slowly, as the isotopomer (PNP)Sc(ND[DIPP])(eta(2)-NC(5)H(4)) (2-d(1))

253 both highly enriched isotopomers and labeled isotopomers present in low abundance against a natural i

254 , Rb(+), NH(4)(+)), and produced mixtures of isotopomers, ranging from singly exchanged H(1)D(5)- to

255 predicted, the less thermodynamically stable isotopomer rearranges at cryogenic temperatures in the d

256 revious HDX MS methods did not resolve these isotopomers, requiring a natural-abundance-only (before

257 ed to detect 2'-deoxycytidine and its stable isotopomer, respectively.

258 nt evidence from enzyme activity assays, the isotopomer results from both gas chromatography-mass spe

259 vatives, thus diminishing the possibility of isotopomer scrambling during GC analysis.

260 o those of the para-aminobenzoic acid (pABA) isotopomers; second, substituting an NH2 solid phase ext

261 of the 1((15)N) (50% Fe identical with(15)N) isotopomer shows a resonance at 1016 ppm (vs externally

262 By tracing this isotopomer signal in herbarium samples of natural C3 vas

263 N2O isotope and isotopomer signatures, as well as molecular genetic resu

264 + 2 profile example above, deconvolving the isotopomer species resulting from deuterium incorporatio

265 On the basis of batch experiments, an isotopomer-specific kinetic model, and density functiona

266 From these experimental MS/MS isotopomer spectra, precursor atoms can be mapped to fra

267 isotopomer distribution analysis (MIDA) and isotopomer spectral analysis (ISA) represent such method

268 imates of fractional synthesis calculated by isotopomer spectral analysis (ISA), a nonlinear regressi

269 l was decreased by progestins as measured by isotopomer spectral analysis, whereas newly synthesized

270 ts with D2 to afford [D1D](0), but not mixed isotopomers such as [H1D](0).

271 The synthesis and characterization of isotopomer tandem nucleic acid mass tag-peptide nucleic

272 over the range 10-45 degrees C for the three isotopomers Tc((16)O)(4)(-), Tc((16)O)(3)((18)O)(-), and

273 strong ion at an m/z of 576.2703 for the 16O-isotopomer that shifts to 580.2794 in the 18O-isotopomer

274 olyzed biomass and increases the coverage of isotopomers that can be quantified, making it a promisin

275 ntly consisting of highly and fully labelled isotopomers; the total plant material contained more tha

276 was made along with its doubly (15)N-labeled isotopomer to explore bonding interactions at each imida

277 o-2'-deoxyuridine 5'-diphosphate provides an isotopomer to perturb EPR spectra in a predictable manne

278 the R132H-isobolome by using targeted (13)C isotopomer tracer fate analysis to trace the metabolic f

279 No difference was detected in the isotopomer trends between beet sugar samples covering th

280 In examples shown here, isotopomer uncertainties were calculated with relative s

281 oisotopic mobilities being observed for some isotopomers (up to a ~0.04% difference in mobility).

282 and (2)H (D) relaxation rates of (13)CH(2)D isotopomers using a single sample.

283 port on separations of ion isotopologues and isotopomers using ultrahigh-resolution traveling wave-ba

284 ial to represent any and all combinations of isotopomer variations of that material and to determine

285 of the labeled siderophore, analysis of the isotopomers was conducted via one-dimensional (1)H and (

286 Differential production of lactate isotopomers was due to deuterium loss during glycolysis.

287 es were identified, and the isotope ratio of isotopomers was quantified.

288 e tracer, [1, 2-13C(2)]glucose (a M2 glucose isotopomer), was administered at 1mg/g body weight to 4-

289 , the calculated EIEs for the monodeuterated isotopomers were analyzed.

290 ESI-cleavable peptide TNT isotopomers were introduced into PNA oligonucleotide seq

291 s, monodeuterated 1,5-dimethylsemibullvalene isotopomers were prepared and investigated by IR spectro

292 Aqueous solutions of the three (13)C isotopomers were studied by (1)H and (13)C NMR spectrosc

293 These isotopomers were synthesized by coupling cytidylyl-(3',5

294 e with 93% (13)C isotopic purity, and 55% of isotopomers were uniformly labelled.

295 typically involve measurements on (13)CHD(2) isotopomers, where the (13)C relaxation mechanism is par

296 population of the desired (13)CHD(2) methyl isotopomer, which is ideal for (1)H and (13)C spin relax

297 ange of trans beta-carotene (tbeta-carotene) isotopomers with a peak enrichment at molecular mass plu

298 s are able to monitor O(2) and CO(2) and its isotopomers with excellent sensitivity and time resoluti

299 oacetyl derivatives of ethyl-esterified pABA isotopomers with heptafluorobutyl derivatives, which are

300 ow here that fragmentation of glutamate mass isotopomers yields additional mass spectral data that si