ライフサイエンスコーパス: itching

1 nd induced pathophysiological responses (ie, itching).

2 1, with higher scores indicating more severe itching).

3 s leading to plasma extravasation, pain, and itching.

4 hypersensitivity, tooth pain, swelling, and itching.

5 n blood pressure of > or =20% or intolerable itching.

6 condition characterized by inflammation and itching.

7 rses suggested Na(V)1.8 to sustain prolonged itching.

8 anti-inflammatory actions that also reduces itching.

9 associated with the unpleasant sensation of itching.

10 ous T cell lymphoma (CTCL) experience severe itching.

11 telet aggregation, blood clotting, pain, and itching.

12 An alternative scoring is based on itching.

13 were dryness, redness, burning sensation and itching.

14 ress has been made to uncover the mystery of itching.

15 sease characterized by recurrent episodes of itching.

16 herpesvirus infections is peripheral pain or itching.

17 symptoms: rhinorrhoea, blockage, sneezing or itching.

18 at is characterized by recurrent episodes of itching.

19 xis with implications for treatment of wound itching.

20 provide new insight into mechanisms of skin itching.

21 nt sensations, as has been shown for pain or itching.

22 motor skills, 48.7 vs 53.0 [P = .002]; pain/itching, 15.8 vs 33.5 [P < .001]; and worry/concern, 31.

23 The most common adverse events were itching (211 patients in the imiquimod group vs 129 in t

24 vs. 5.9%), fatigue (4.1% vs. 5.9%), and skin itching (3.6% vs. 3.2%).

25 Rash (84 reports), itching (46 reports), and vomiting (30 reports) were the

26 ms: 11.9%-20.9%), headache (4.7%-14.3%), and itching (5.8%-13.1%), which were predominantly mild and

27 14), facial dysmorphism (13/14), intractable itching (9/14), and elevated bile acids (5/6).

28 IgE production, but may also be relevant to itching after tick bites which can last for weeks.

29 Symptoms range from burning pain to itching, also carrying substantial psychological morbidi

30 nflammatory skin condition marked by intense itching and a weakened skin barrier.

31 ients valued treatments capable of relieving itching and burning skin and preferred to apply topical

32 ting skin condition characterized by intense itching and chronic inflammation.

33 also showed statistically significantly less itching and conjunctival redness at 31 and 29 of 33 othe

34 minant disorder associated with chronic skin itching and deposition of epidermal keratin filament-ass

35 asis (VVC) is a common cause of vulvovaginal itching and discharge.

36 ary outcomes included additional measures of itching and disease severity.

37 egg yolk, resulting in a cough, hoarseness, itching and hypotension.

38 aracterized by generalized redness, scaling, itching and increased numbers of circulating atypical T

39 Our results indicate that TLR7 mediates itching and is a potential therapeutic target for anti-i

40 Manifestations range from itching and minor pain to neurological symptoms, cardiac

41 nd elevated IgM levels, which correlate with itching and pathology.

42 observed, except pain at the injection site, itching and redness.

43 reased quality-of-life impairment, including itching and sexual dysfunction.

44 I inflammatory response, thereby alleviating itching and skin lesions in AD.

45 anogenital area, where it causes intractable itching and soreness.

46 itis, are clinically characterized by severe itching and type 2 immunity-associated hypersensitivity

47 All children presented with perianal itching and visible passage of worms (100%).

48 gastrointestinal symptoms), and reduction in itching and whealing after standardized skin provocation

49 Itching and/or burning skin occurred in a sizable percen

50 sis, refractory symptoms (eg, muscle cramps, itching), and malfunction of dialysis access can interfe

51 adherence of the eyelids on waking, lack of itching, and absence of a history of conjunctivitis are

52 Dry skin, fatigue, itching, and bone/joint pain each were reported by > or

53 ns with groin venous access, lower extremity itching, and deep venous thrombosis.

54 Injection site pain, itching, and erythema (mostly mild) were the only solici

55 by elevated serum bile acid concentrations, itching, and fat malabsorption.

56 couver Scar Scale (VSS), asked to rate their itching, and genotyped for 8 MC1R SNPs.

57 d skin resulting in scarring due to constant itching, and hyperplasia of lymphoid cells, haematopoiet

58 use, key VKC symptoms (photophobia, tearing, itching, and mucous discharge), and quality of life (QoL

59 reatment on symptoms, functioning, emotions, itching, and pain.

60 o 5-point scores for severity of congestion, itching, and rhinorrhea), A(min) (in square centimeters)

61 onsisting of blocked nose, runny nose, nasal itching, and sneezing was used to evaluate symptoms.

62 placebo, the mean score for vaginal pH, VAS itching, and total Nugent score was significantly decrea

63 emotional behavior, family functioning, pain/itching, appearance, satisfaction with care, and worry/c

64 eir worst symptoms were, 15 (88%) identified itching as the worst or 1 of the worst symptoms.

65 01), and the occurrence of perianal rash and itching as well as the use of protective pads decreased

66 eficits were accompanied by greatly enhanced itching, as suggested by (1) sensitization of both hista

67 C-day 8, were reported by subjects of ocular itching at 3, 5, and 7 minutes post CAC and investigator

68 pain, tenderness, and (much less frequently) itching at the injection site.

69 The most common adverse event was mild itching at the tick attachment site.

70 ced pain behavior was increased, whereas the itching behavior was unchanged in CCI models compared wi

71 tudies have described nocturnal increases in itching behavior, suggesting a role for the circadian rh

72 dose was 0.5%, with transient oropharyngeal itching being the most common, and there were no dosing

73 on, early satiety, inactivity, night sweats, itching, bone pain, abdominal discomfort, weight loss, a

74 neous nerves and an accompanying increase in itching, both of which were abolished in the absence of

75 d with intense acute flares of inflammation, itching, burning pain, vasodilatation, and redness of th

76 incidence of local side effects (redness and itching) but a similar incidence of systemic side effect

77 D) is predominantly characterized by intense itching, but concomitant skin pain is experienced by mor

78 women with BV significantly relieved vaginal itching by decreasing vaginal pH and Nugent scores and i

79 However, chronic persistent itching can be devastating.

80 PZ-235 significantly reduced itching caused by wasp venom peptide degranulation of ma

81 s) by enhancing "green vegetable" notes and "itching" character and the "burning" effects linked to h

82 understanding the pathophysiology of chronic itching conditions, will hopefully contribute to the dev

83 ad evidence of probable neuropathic pain and itching defined as distal thermal sensory loss (confirme

84 ically used for chronic hepatic diseases and itching dermatitis, modulates the pathological processes

85 Cutaneous neurofibromas (cNFs) can cause itching, disfigurement, pain, and emotional difficulties

86 ense photophobia, redness, watering eyes and itching due to an inflammatory-allergic reaction of the

87 For example, our results suggest that itching during inflammatory skin diseases such as atopic

88 Thus, cDC2s promote itching during skin would healing via a TGF-beta-IL-31 a

89 receptor, and Janus kinase) or specifically itching (eg, NK1R inhibitors) are also being studied.

90 Itching engages specific brain regions that are implicat

91 often experience flare-ups characterized by itching erythema, edema, and often vesicles occurring wi

92 requently considered but may cause localized itching (especially in the genital area) and generalized

93 luded rhinorrhoea, forehead/facial sweating, itching eye, eyelid oedema, sense of aural fullness and

94 nth history of epigastric pain and jaundice, itching, flushing, cough and wheezing.

95 oms, such as stinging, burning, tearing, and itching, following cataract surgery should prompt consid

96 nalicular insert to provide relief of ocular itching for up to 4 weeks in subjects with allergic conj

97 uded additional VAS items (burning/stinging, itching, foreign body sensation, eye discomfort, photoph

98 re that was further reflected in more severe itching, frequent flares, and increased disease severity

99 pants were included in the study: 137 in the itching group (mean [SD] age, 62.7 [9.9] years; 74 [54%]

100 bjective adverse events (erythema, swelling, itching, headache, root hypersensitivity, or pain) were

101 The frequency of nighttime itching in 190 asthmatic inner-city children with AD, as

102 s into healthy skin was sufficient to induce itching in a manner dependent on IL-31 expression.

103 Frequency of itching in FTLD-SD and AD and neuroanatomic correlates.

104 Later, she felt itching in her mouth.

105 After that she felt discomfort and itching in her oral cavity.

106 Reproxalap was effective at reducing ocular itching in patients with allergic conjunctivitis.

107 ythematoedematovesicous lesions with intense itching in the acute phase.

108 ts in abnormal immune responses and constant itching in the skin.

109 Itching, induced by irritants or allergens that stimulat

110 n the weekly mean score on the 24-hour Worst Itching Intensity Numerical Rating Scale (WI-NRS; scores

111 elikefalin treatment (defined as >=30% Worst Itching Intensity Numerical Rating Scale score reduction

112 as assessed using the patient-reported Worst Itching Intensity Numerical Rating Scale.

113 Nighttime itching interfering with sleep, Rajka-Langeland, and Ecz

114 vaginal symptom in the month prior (dryness, itching, irritation, soreness, or dyspareunia) and clini

115 Itching is common in geriatric populations and is freque

116 tion of these individuals seek medical help; itching is the most consistent sign in allergic conjunct

117 Itching is the predominant symptom of skin disease but i

118 ents with bvFTD and itching vs bvFTD without itching, itching was associated with right-lateralized g

119 "catastrophizing cognitions" with respect to itching (Juckreiz-Kognitions-Fragebogen questionnaire),

120 signs can include intense vulvar and vaginal itching, low back pain, uterine cramps, fetal distress,

121 Asian race, absence of itching, lung disease, low serum albumin levels, low pla

122 However, a patient's lack of itching makes candidiasis less likely (range of LRs, 0.1

123 e relationship between neurodegeneration and itching may help in the management of itch in older indi

124 Ocular itching (n = 101; 83.5%) was the predominant symptom and

125 cough (n = 115, 16%), rash (n = 66, 9%), and itching (n = 37, 5%).

126 ing (n = 10; 23%), photophobia (n = 6; 14%), itching (n = 4; 9%), swelling (n = 2; 5%), and infection

127 ded cough (n=115, 16%), rash (n=66, 9%), and itching (n=37, 5%).

128 ermittent exposure to seasonal pollen causes itching, nasal congestion, and repeated sneezing, with p

129 ifitegrast-treated participants at day 42 in itching (nominal P = 0.0318), foreign body sensation (no

130 as promising drug targets for treating pain, itching, obesity, cancer, dry eye disease, and inflammat

131 0.3), and sneeze of -8.8 (SE, 1.5); group 2, itching of -0.6 (SE, 0.3), rhinorrhea of -0.8 (SE, 0.3),

132 cebo: group 1, congestion of -0.7 (SE, 0.3), itching of -1.0 (SE, 0.3), rhinorrhea of -1.3 (SE, 0.3),

133 symptoms of nasal congestion, sneezing, and itching of the eyes, nose, and throat.

134 hinorrhea, postnasal drainage, sneezing, and itching of the eyes, nose, and throat.

135 tive reactions ranging in severity from mild itching of the oral mucosa to bronchospasm.

136 mune and inflammatory disorders and constant itching of the skin.

137 Thus, itching of undetermined origin (IUO) may indicate the pr

138 From 795 records where itching or a related phrase was endorsed, 137 had IUO.

139 Such release may contribute to common itching or intensify the inflammatory response in vivo.

140 Positive criteria are based on itching or quoted according to a composite score.

141 tching networks, resulting in uncontrollable itching or skin picking.

142 gnificant difference in disability, fatigue, itching, or patient or clinician global disease severity

143 Itching, or pruritus, is defined as an unpleasant cutane

144 color, such as skin irritation, tenderness, itching, or skin becoming darker, may allow physicians t

145 ht breast associated with redness, pain, and itching over the past month (Fig 1).

146 ht breast associated with redness, pain, and itching over the past month.

147 dy outcomes: coping behavior with respect to itching (P < .001), quality of life assessed by using th

148 They included headache, swelling, itching, pain, and root hypersensitivity.

149 as preferred over placebo, for the relief of itching, pain, discomfort, edema, and redness in respons

150 owever, there was a dose-related increase in itching, pain, edema, and staining of the anogenital ski

151 atory vulvar skin disorder leading to severe itching, pain, scarring, and an increased risk of malign

152 ars produce significant morbidity, including itching, pain, stiffness, and contracture, but best mana

153 est attribution to CKD (fatigue, depression, itching, poor mobility, poor sleep, and dry mouth).

154 cratching deficits in response to all of the itching (pruritogenic) stimuli tested, irrespective of t

155 ype of ichthyosis, many patients suffer from itching, recurrent infections, sweating impairment (hypo

156 4.8% of doses, with transient oropharyngeal itching reported most commonly.

157 ory nerve substance P and, in turn, increase itching responses.

158 CNFs cause disfigurement, pain, burning, and itching, resulting in substantially reduced QOL in patie

159 mptoms of allergic rhinitis, including nasal itching, rhinorrhea, and sneezing, although most agents

160 ndpoint was area under the post-acute ocular itching score (range = 0-4) curve from 10 to 60 minutes

161 2 points improvement from their peak ocular itching score at baseline.

162 Vaginal pH, VAS itching score, total Nugent score, and vaginal health in

163 tatistically significantly lower mean ocular itching scores than placebo at all time points (P <.001)

164 er understand the relationships among sleep, itching, scratching, and chronic itch conditions and the

165 amygdala, contribute to dysregulation of the itching-scratching networks, resulting in uncontrollable

166 Contagious behaviors such as yawning and itching/scratching have mirror-like properties and clear

167 t common side effect was a mild tingling and itching sensation during stimulation (100%) and temporar

168 s of this class of neurons parallel the pure itching sensation this stimulus elicits in humans, and m

169 including poor concentration associated with itching, sleep deprivation, or adverse effects of medica

170 qualitative study suggests the importance of itching, sleep disturbance, and other symptoms and impac

171 n the tissues involved such symptoms include itching, sneezing, irritation, vasodilation, and reflex

172 s characterized by typical symptoms of nasal itching, sneezing, watery discharge and congestion.

173 ciated with (1) breast pain, (2) bother from itching, stinging/burning, swelling, or hurting of the t

174 changes (evolving) of size, shape, symptoms (itching, tenderness), surface (especially bleeding), and

175 gh sunburn can produce severe uncontrollable itching, the underlying mechanisms of UV irradiation-ind

176 ts on the overall DLQI (47% vs 14%; P<.001), Itching VAS (38% vs -0.2%; P<.001), and PSA frequency an

177 Among patients with bvFTD and itching vs bvFTD without itching, itching was associated

178 bvFTD and itching vs bvFTD without itching, itching was associated with right-lateralized gray matte

179 More frequent itching was found in FTLD-SD (95/248 patients [38%], of

180 Oropharyngeal itching was more commonly reported by peanut SLIT than p

181 Time to complete resolution of ocular itching was statistically faster for both reproxalap con

182 Perianal itching was the only side effect reported and was noted

183 The odds of itching were 2.4 (95% CI, 1.48-3.97) times higher for FT

184 Pain, swelling, erythema, and itching were the most commonly reported local symptoms a

185 vements in quality of life, symptom control (itching, wheals and flares, flushing, tachycardia, and h

186 qualitative details and accurately identify itching with undetermined origin (IUO).