ライフサイエンスコーパス: junctional

1 Actomyosin tension triggers ZO-1 junctional accumulation by driving retrograde actomyosin

2 letion of the 4.1R(+17b) forms both decrease junctional actin and attenuate the recruitment of spectr

3 lial tissues and localizes to the apical and junctional actin cortex in intestinal and kidney epithel

4 on assembly, but rather is needed for proper junctional actin regulation during elongation.

5 of branched morphologies relies strongly on junctional activity, enabling temporary aggregations of

6 ext, the developmental increase of isotropic junctional actomyosin reduces the rate of neighbor excha

7 ing generation of local force dipoles in the junctional actomyosin.

8 bination of gene segments with non-templated junctional additions (on B cells) is unknown-although it

9 trocyte TJs of claudin 1 (CLDN1), CLDN4, and junctional adhesion molecule A (JAM-A) subunits is induc

10 t in intestinal epithelial barrier function, junctional adhesion molecule A knockout mice, F11r(-/-)

11 JAM-A (junctional adhesion molecule A) is a transmembrane compo

12 le fragment of its cellular receptor, feline junctional adhesion molecule A.

13 Junctional adhesion molecule C (JAM-C) is an immunoglobu

14 the main proteins associated with it such as junctional adhesion molecule-1 and vascular endothelial

15 protein sigma1 engages glycan receptors and junctional adhesion molecule-A (JAM-A) and is thought to

16 Junctional adhesion molecule-A (JAM-A), an epithelial ti

17 ction, sigma1 engages sialylated glycans and junctional adhesion molecule-A (JAM-A), triggering uptak

18 g integrin alpha3beta1, VE-cadherin, ICAM-2, junctional adhesion molecule-B (JAM-B), laminin, and cel

19 map the intracellular trafficking routes of junctional adhesion molecule-C (JAM-C).

20 Initial investigations into TJ proteins and junctional adhesion molecules (JAM) in cancer suggested

21 JAM2 encodes for the junctional-adhesion-molecule-2, a key tight-junction pro

22 e of cardiac function via activation of post-junctional adrenergic receptors.

23 ved in forming an R-loop includes four terms-junctional and base-pairing energies and energies associ

24 he first clinical trials of gene therapy for junctional and dystrophic epidermolysis bullosa.

25 unctional disassembly are periodic pulses of junctional and medial myosin II that result in progressi

26 These observations argue that the balance of junctional and nuclear beta-catenin activity has a profo

27 rrhages from the maternal vasculature in the junctional and/or labyrinthine zones in E12.5 placentas.

28 r fluids of patients affected by dystrophic, junctional, and simplex EB.

29 e that SGEF plays a key role in coordinating junctional assembly and actomyosin contractility by brin

30 transcriptional activity and induces a tight junctional barrier at the Glia Limitans.

31 ry neuroepithelium, especially at the apical junctional belt of the sustentacular cells.

32 n coordinating the generation of ipsilateral junctional belts whilst simultaneously releasing contral

33 he immunoglobulin heavy chain that, owing to junctional biases during V(D)J recombination, appear muc

34 n assembly, and loss of Rap1B led to loss of junctional border organization.

35 ists of scaffold proteins that interact with junctional cadherins, polarity proteins and the cytoskel

36 ave suggested novel signaling roles for "non-junctional" cadherins (NJCads); however, the function of

37 RQOL) domains in patients with esophageal or junctional cancer who received neoadjuvant chemoradiothe

38 ecognized molecular mechanism for inhibiting junctional CDC-42 to control actin organization and AJ p

39 The post-junctional cell(s) mediating tonic inhibition have not b

40 We investigated the post-junctional cells mediating tonic inhibition in the proxi

41 exin (Cx) protein forms hemichannels and gap junctional channels, which play diverse and profound rol

42 n located GPa at sarcoplasmic reticulum (SR) junctional cisternae, and apo-GP at Z disk.

43 atter was restricted by accessibility of non-junctional claudin molecules such as claudin-4 at apical

44 icromolar [Ca(2+) ]i , in the submembrane or junctional cleft space, is not required to maximize [Ca(

45 metallopeptidase domain 10 (ADAM10) promotes junctional clustering of ADAM10 and alpha-toxin-mediated

46 junctional rest tensions, which may explain junctional collapse during convergence and extension in

47 etaV was invariably detected near the apical junctional complex and above the cuticular plate, a dens

48 onferring mechanosensitivity upstream of the junctional complex and integrins.

49 s by maintaining the integrity of the apical junctional complex and its associated actin regulatory p

50 f transporters and specialized intercellular junctional complex components.

51 revealed that Notch signaling induces apical junctional complex genes that regulate cell adhesion and

52 fficking, which were present near the apical junctional complex in the hair cells of mammalian ancest

53 thelial flow mechanotransduction through the junctional complex is mediated by a specific pool of VE-

54 CLAMP bound to actin and apical junctional complex proteins but not microtubules in IECs

55 ing mislocalization of mutant huntingtin and junctional complex proteins, defects in neuroprogenitor

56 The epithelial junctional complex, composed of tight junctions, adheren

57 58 is essential for flow sensing through the junctional complex.

58 and the subsequent damage of the epithelial junctional complex.

59 formation revealed that disruption of apical junctional complexes (AJCs) was responsible for PH in Ne

60 independently of the establishment of apical junctional complexes and identify Rgma-induced Neo1 prot

61 geometric graph, with nodes corresponding to junctional complexes and with edges corresponding to spe

62 er scaffolds regulating assembly of distinct junctional complexes at different times and places.

63 tabilization of SDs and their replacement by junctional complexes between abnormally broadened foot p

64 Junctional complexes between endothelial cells form a dy

65 -1 and stabilin-1 and was facilitated by the junctional complexes between HSECs.

66 ocalization of Par3, a regulator of cellular junctional complexes defining mammary epithelial polarit

67 ght be related to the emergence of different junctional complexes during metazoan evolution.

68 vary glands due to disruptions of epithelial junctional complexes, likely secondary to elevated activ

69 secreted bacterial protease disrupts apical-junctional complexes, paving the way for H. pylori to ac

70 role for this pathway in establishing apical junctional complexes.

71 lipid bilayer by ankyrin and by actin-based junctional complexes.

72 independently of the establishment of apical junctional complexes.SIGNIFICANCE STATEMENT The neural t

73 luding cell differentiation, the presence of junctional complexes/desmosomes and microvilli, and the

74 epithelium, by altering expression of tight junctional components and dynamic loosening of cellular

75 (gCa(V)) using verapamil or by reducing gap junctional conductance (Gj) using carbenoxolone or by ba

76 ated that such asymmetry strongly depends on junctional conductance and can lead to the unidirectiona

77 model can account for dynamic modulation of junctional conductance during the spread of electrical s

78 odel allowed us to replicate the kinetics of junctional conductance under different levels of intrace

79 was measured while simultaneously monitoring junctional conductance via dual whole-cell/perforated pa

80 tion potentials, can induce a rapid decay of junctional conductance, thus demonstrating spiking activ

81 interdependency of sodium, calcium, and gap junctional conductances to safeguard cardiac conduction.

82 greater CE cell loss, including loss of ZO-1 junctional contacts and corneal edema, in female than ma

83 signalling and the organization of adherens junctional contacts.

84 ate that capillary-enwrapping projections of junctional, contractile pericytes within a postarteriole

85 of fusiform and posterior temporo-occipital junctional cortices.

86 We here show that Cx43 mediates gap-junctional coupling between collectively invading breast

87 sts by approximately 20 mV and increased gap junctional coupling between myofibroblasts and cardiomyo

88 a factor of 4 by physiological levels of gap junctional coupling between sister MCs at the same glome

89 m gap junction plaques and produce levels of junctional coupling similar to those for wild-type Cx32.

90 tentials and cardiomyocyte-cardiomyocyte gap junctional coupling, TGF-beta1 depolarized cardiomyocyte

91 if they do, produce little or no detectable junctional coupling.

92 We found that Canoe helps cells maintain junctional-cytoskeletal linkage when challenged by the j

93 Multiple proteins play roles in junctional-cytoskeletal linkage, but the mechanisms by w

94 ion of 4.1R(+17b) forms does not disrupt the junctional cytoskeleton and AJs during the steady-state

95 e of calcium signaling rescues the cell-cell junctional defects.

96 A major driver of apical constriction and junctional disassembly are periodic pulses of junctional

97 ter embryos to assess apical domain loss and junctional disassembly.

98 After junctional disruption with the FBA, dilatation was simil

99 oblastic morphology, increased intercellular junctional distance, and induced paracellular permeabili

100 ments of Vgamma9 and Vdelta2 chains with low junctional diversity and usage of non-TRDJ1 gene segment

101 cytoskeletal network may contribute to cell junctional dynamics.

102 he fixed point, giving rise to quasiperiodic junctional dynamics.

103 Finally, loss of Ck1alpha also blocked junctional E-cadherin reduction around the wound.

104 ansduced by the Src tyrosine kinase to alter junctional E-cadherin trafficking.

105 nderlying molecular abnormality: EB simplex, junctional EB, dystrophic EB and Kindler EB.

106 nds, particularly dominant in dystrophic and junctional EB.

107 her endothelial cells or pericytes increases junctional endothelial permeability in lung and brain se

108 ently, diseases with epidermal loss, such as junctional epidermolysis bullosa (EB).

109 eshift variants causing AI in the absence of junctional epidermolysis bullosa, and highlights the sha

110 f-function variants in LAMB3 cause recessive junctional epidermolysis bullosa, characterized by life-

111 have demonstrated the similarity between the junctional epithelium (JE) and the hyperplasic epitheliu

112 Oral gingival tissue, especially the junctional epithelium (JE), is constantly exposed to sub

113 , a modified barrier has evolved, called the junctional epithelium (JE).

114 e expression of the junction proteins at the junctional epithelium and increased the alveolar bone lo

115 EP favors inflammatory cell infiltration and junctional epithelium, cementum with alveolar bone crest

116 Histology, ISH, and IHC revealed disrupted junctional epithelium, connective tissue destruction, ba

117 port that SCCs are present in mouse gingival junctional epithelium, where they express several Tas2rs

118 Junctional epitope antibodies, like VHH6, not only offer

119 Here we introduce VHH6, a junctional epitope antibody capable of specifically reco

120 ical techniques have been used to prove the "junctional epitope" nature of VHH6, a camelid single dom

121 e faster than the slow atrioventricular (AV) junctional escape rhythm observed in control CAVB animal

122 n/p120-catenin interaction and, in turn, the junctional expression of E-cadherin.

123 broad cohort of epithelial genes, including junctional factor dlg-1 Accumulation of DLG-1 protein is

124 ) and promoted the formation of postsynaptic junctional folds (P < 0.001), in particular in fast-twit

125 Larger junctional force magnitudes are associated with faster c

126 vidual cells and interactions with cell-cell junctional forces during collective cell migration.

127 Further, cell-cell junctional forces exhibit distinct spatial patterns duri

128 rdial atrial chamber volume generates higher junctional forces within endocardial cells.

129 ty and contractility and multicellular-level junctional forces.

130 se of the additional regulation of cell-cell junctional forces.

131 c wounds, and we show that patients with the junctional form of EB have significantly more cells infi

132 nd also reduce E-cadherin during the initial junctional formation of the AJ reassembly process.

133 leukocytes preferentially extravasate across junctional gaps in the endothelial monolayer (paracellul

134 e and macromolecular flux and assessed tight junctional gene expression and protein localization both

135 s, upregulating Wnt-related signaling and EC junctional gene expression, respectively, and downregula

136 meshworks, which control the apical area and junctional geometry of these cells during lens developme

137 If the formation and/or junctional incorporation of ZO-1 clusters is impaired, t

138 ears to be the dominant kinase essential for junctional integrity and contractile tension at epitheli

139 LPA disrupts junctional integrity and epithelial cohesion in vitro ho

140 ROCK inhibition rescued cytoskeletal or junctional integrity changes induced by inactivation of

141 ctionally, CdGAP-Ajuba interaction maintains junctional integrity in homeostasis and diseases: (i) ga

142 ponses to laminar shear stress and regulates junctional integrity through modulation of calcium signa

143 We further showed that retention of adherens junctional integrity was caused by the up-regulation of

144 ewed toward loss of differentiation, reduced junctional integrity, and impaired innate defense.

145 ess, and is necessary for the maintenance of junctional integrity, cell elongation, and suppression o

146 Its impact on junctional integrity, however, remains obscure.

147 itor specific to Cx43, we show that Cx43-gap junctional intercellular communication (GJIC) influences

148 Gap junctional intercellular communication (GJIC) is widely

149 pression of networks for tight junction, gap junctional intercellular communication, and transmembran

150 dock between adjacent cells to allow for gap junctional intercellular communication.

151 +) store into the peripheral subsarcolemmnal junctional (j-SR) and the much more abundant central non

152 However, junctional laser ablation unexpectedly showed that junct

153 not components of the Wash complex, reduces junctional levels of the core proteins Flamingo and Stra

154 Therefore, we hypothesize that junctional linearity is a better and more predictive rea

155 Compounds that increased junctional "linearity" (i.e., stability) counteracted th

156 hat basal EphrinB2/EphB4 signalling controls junctional localisation of the tight junction protein CL

157 Intriguingly, Stepping stone's junctional localization also seems partly dependent on S

158 is mapped surface was required for Steppke's junctional localization and tissue regulation.

159 re protein Frizzled, we show that its stable junctional localization is promoted by the core proteins

160 g 4.1R(+17b) forms in depleted cells rescues junctional localization of actin, spectrin, and E-cadher

161 While junctional localization of DAPLE is necessary for this f

162 one was necessary and largely sufficient for junctional localization.

163 in TTX-insoluble fractions, consistent with junctional localization.

164 that leads to defective Tie2 clustering and junctional localization.

165 during vascular morphogenesis by fine-tuning junctional mechanocoupling between endothelial cells.

166 monstrate that Merlin is a component of cell junctional mechanosensing complexes and defines a specif

167 Junctophilin-2 (JPH2) is a part of the junctional membrane complex that facilitates calcium-han

168 RATIONALE: Junctional membrane complexes (JMCs) in myocytes are cri

169 e regulation of Crumbs by Neuralized lowered junctional myosin and led to imprecision in the integrat

170 mplex levels also results in accumulation of junctional myosin.

171 At homotypic contacts, junctional N-cadherin bonds downregulate Myosin-II contr

172 j-SR) and the much more abundant central non-junctional (nj-SR) SR.

173 tions and the subsequent mode of diapedesis, junctional or nonjunctional, can be context dependent an

174 in loading order, resulting in many possible junctional outcomes from one DSB.

175 tions of these models revealed that this gap junctional/paracrine mechanism accounts for up to 23% of

176 ecessary for trans-endocytosis, and adhesive junctional PCP complexes appear to be destined for degra

177 be of high medical relevance because loss of junctional Pg is a hallmark of arrhythmogenic cardiomyop

178 intestinal epithelium brush border membrane, junctional polarity, and maturation.

179 The tight junctional pore-forming protein claudin-2 (CLDN-2) media

180 but the resting rate of miniature excitatory junctional potentials (mEJPs) is significantly lower in

181 tude of both evoked and miniature excitatory junctional potentials.

182 Our four-way junctional pre-catalytic structure differs significantly

183 Mg(2+) ions relative to a reported three-way junctional pre-catalytic structure of the twister-sister

184 s both structural changes in the actin-bound junctional protein complex and physical forces spanning

185 The contribution of the gap junctional protein connexin 36 (Cx36) to the regulation

186 Expression of the redox-sensitive gap junctional protein Cx43 (Connexin 43) was reduced in the

187 rrier (IEB) function with loss of desmosomal junctional protein desmoglein 2 (DSG2) is a hallmark in

188 circuit, by increasing targeting of the gap junctional protein innexin shaking-B to gap junctions (G

189 Deltalens), show that loss of this cell-cell junctional protein leads to lens degeneration, necrosis

190 Similarly, anti-inflammatory agents, junctional protein regulators, analgesics, secretagogues

191 -cadherin, a major endothelial cell-specific junctional protein that controls vascular integrity.

192 s suggest that striatin is a novel cell-cell junctional protein that functions to maintain correct ce

193 express high levels of Claudin-5 (CLDN5), a junctional protein that stabilizes ECs, and are importan

194 into the post-translational modifications of junctional proteins and signaling pathways regulating pl

195 yers with similar levels and distribution of junctional proteins and transendothelial electrical resi

196 ) and neuropilin (NRP)-1 and 2, but not with junctional proteins associated with the transmigration o

197 duced "zipper-like" contiguous expression of junctional proteins at sinusoidal endothelial cell-cell

198 The CTE-associated loss of the cell junctional proteins EpCAM and claudin 7 was also prevent

199 Junctional proteins Neph1 and ZO-1 and their interaction

200 Although transcripts of junctional proteins such as connexin43, ZO-1, occludin,

201 ilamentous actin network, and recruitment of junctional proteins that likely form autotypic junctions

202 a/Delta) mice have increased TEWL, disrupted junctional proteins, and increased susceptibility to dev

203 ithelial cells by lowering the expression of junctional proteins, such as zonula occludens-1, occludi

204 However, for many junctional proteins, the mechanisms of junctional remode

205 iated redistribution of the major epithelial junctional proteins.

206 levels of plasma membrane-associated lateral junctional proteins.

207 barrier-associated transcription factors and junctional proteins.

208 KO mice revealed a reduced expression of BBB junctional proteins.

209 al permeability and the expression levels of junctional proteins.

210 ed altered subcellular distribution of tight junctional proteins.

211 s is induced by bridging plasma membranes by junctional proteins.

212 R treatment induced disorganization of tight junctional proteins.

213 as TCF/LEF1 and ZIC3 TFs, transporters, and junctional proteins.

214 F-actin-binding activity and organization of junctional-proximal actin in vivo.

215 Using a cutoff 5% allele fraction for junctional reads, 7 different rearrangements were presen

216 Loss of Sidekick causes defects in cell and junctional rearrangements in actively remodeling epithel

217 ap-foam cells exhibit similar size-dependent junctional rearrangements.

218 downstream targets for miR-34 identified the junctional receptor CNTNAP4/Neurexin-IV (Nrx-IV) and the

219 nsion on the E-cadherin complex promoted the junctional recruitment of the protein LGN, a core compon

220 coil domain was necessary and sufficient for junctional recruitment.

221 90)BCR-ABL peptides derived from the BCR-ABL junctional region and alternative splicing, and of adopt

222 ently, App also recruits Dachs to the apical junctional region through protein-protein association, t

223 ification and recruiting Dachs to the apical junctional region, thereby promoting tissue growth.

224 n of the atypical myosin Dachs at the apical junctional region, which in turn promotes growth by inhi

225 rected bnAbs, sequence differences in CDR H3 junctional regions during VDJ recombination can alter re

226 levels, vasopermeability, and alteration in junctional-related proteins were observed in the retinas

227 " phenotype by enhancing phosphorylation and junctional release of beta-catenin to promote Wnt signal

228 Pg-mutant S665A abrogated both cAMP-mediated junctional remodeling and increase of cohesion.

229 Reintroduction of Pyd-P leads to junctional remodeling and their progressive normalizatio

230 a conserved role for Tjp1a/ZO-1 in promoting junctional remodeling in podocytes.

231 -cytoskeletal linkage when challenged by the junctional remodeling inherent in mitosis, cell intercal

232 In infarcted hearts, adverse gap-junctional remodeling occurs in the border zone, where c

233 ases, E-cadherin endocytosis, and epithelial junctional remodeling, as bona fide IRF6 partner protein

234 ications of the endothelial cytoskeleton and junctional remodeling.

235 e found that it was directly correlated with junctional remodeling.

236 rafficking and degradation are necessary for junctional remodelling during cell migration and angioge

237 many junctional proteins, the mechanisms of junctional remodelling have yet to be determined.

238 ing of the mechanisms underlying subcellular junctional reorganization during wound healing, inflamma

239 toskeleton interface plays a crucial role in junctional reorganization.

240 cEC transmembrane current densities and gap junctional resistances can affect K(+)-mediated NVC and

241 ability is affected by cell arrangements and junctional rest tensions, which may explain junctional c

242 ions involved in the spatial localization of junctional RhoA signaling.

243 ed actomyosin cytoskeleton, forms the apical junctional ring (AJR), which must maintain its continuit

244 ples were used to evaluate the hepatobiliary junctional role of the invasive form of DR.

245 pport that invasive DR plays a hepatobiliary junctional role to maintain structural continuity betwee

246 3) reverted ultrastructural abnormalities of junctional sarcoplasmic reticulum and transverse tubules

247 increase of dyads (triads that have lost one junctional sarcoplasmic reticulum element); both results

248 spryn, minispryn and RyR2 co-localise at the junctional sarcoplasmic reticulum of isolated cardiomyoc

249 close association between T-tubules and the junctional sarcoplasmic reticulum to ensure efficient CI

250 KCNQ1 mainly resides in the jSR (junctional sarcoplasmic reticulum), whereas KCNE1 reside

251 in-proximal proteins were components of cell junctional signaling complexes, suggesting that addition

252 gh direct neuro-cardiac coupling at specific junctional sites (neuro-cardiac junctions).

253 utions of ATP and its metabolites within the junctional space.

254 t CD39 and CD73 nucleotidase activity within junctional spaces can exploit their confinement and favo

255 od are the formation of compressed zones and junctional spaces-regions of the extracellular and bath

256 the TMD of JPH1 were able to localize at the junctional SR compartment of the triad.

257 and calsequestrin (CSQ) localization to the junctional SR, and increases endoplasmic reticulum (ER)

258 We discovered that, at the junctional SR, calsequestrin binds to the ER luminal dom

259 hly abundant Ca(2+) handling proteins at the junctional SR, provides new insights into the regulation

260 d at the perinuclear ER and the other at the junctional SR.

261 We also discover that junctional stability is affected by cell arrangements an

262 ) participate and the mechanisms involved in junctional stability or remodeling remain unclear.

263 h Steppke at junctions, and was required for junctional Steppke localization and proper tissue stretc

264 n of mechanosensitive tension remodeling and junctional strain relaxation provides a robust mechanism

265 Second, there is a continuous relaxation of junctional strain that removes mechanical memory from th

266 Steppke coiled-coil domain is linkage to the junctional targeting region of Stepping stone.

267 ohesin Arf-GEF Steppke, which down-regulates junctional tension and facilitates tissue stretching.

268 ilize GTP-RhoA at the ZA, thereby sustaining junctional tension and inhibiting intraepithelial cell m

269 ributes effects of pEMT mainly to diminished junctional tension but attributes those of UJT mainly to

270 aling to drive the polarized organization of junctional tension necessary to build an in vivo epithel

271 Junctional tension of mesendoderm precursors in the epib

272 dherin localizes and tunes EGFR activity and junctional tension to inhibit premature TJ complex forma

273 viscoelastic Maxwell model, and we find that junctional tension, and to a lesser extent viscoelastic

274 verexpressed suggested that anillin promotes junctional tension.

275 ytes and the VECs can separately perturb the junctional tensions of VECs to result in the opening of

276 At steady-state, junctional transmission of lactate (a chemical base) fro

277 malemma), which can explain the advantage of junctional transmission over MCT in vivo.

278 itment of patients with lower oesophageal or junctional tumours planned for an oesophagogastric resec

279 to myofibroblasts during pharmacological gap junctional uncoupling.

280 drive VE-cadherin expression and stabilized junctional VE-cadherin complexes through associated phos

281 Non-junctional ZO-1 clusters form by phase separation, and d

282 in flow within the YSL, which transports non-junctional ZO-1 clusters toward the TJ.

283 Thus, phase separation and flow of non-junctional ZO-1 confer mechanosensitivity to TJs.

284 yde, significantly decreased TER and reduced junctional ZO-1 localization, while increasing FD4 perme

285 n that resides within a candidate niche, the junctional zone (JZ).

286 A 500-mum-wide junctional zone adjacent to the GA border was delineated

287 Increased HRF concentrations in the junctional zone and future macular atrophy may represent

288 differentiate and expressed markers of both junctional zone and labyrinth trophoblast subtypes in a

289 a-HPV field cancerization arises from the HF junctional zone and predispose to squamous cell carcinom

290 mortalised human sebocytes, GATA6 triggers a junctional zone and sebaceous differentiation program wh

291 of pilosebaceous cells expressing markers of junctional zone and upper isthmus follicular stem cells.

292 loss of trophoblast cell density within the junctional zone of the placenta that was not present in

293 muscle cells and reduced vessel areas at the junctional zone of the placenta.

294 ntal labyrinth (L) had a higher sO2 than the junctional zone plus decidua region (JZ+D) in C57Bl/6 mi

295 infected WIS rats had a higher proportion of junctional zone trophoblast cells positive for cytoplasm

296 to trophoblast giant cells (GCs) within the junctional zone, markedly reduced placental serotonin (5

297 oise, sharpness, and ability to evaluate the junctional zone, myometrium, and musculoskeletal structu

298 space, superotemporal to the fovea near the junctional zone, outside the area of GA.

299 either spongiotrophoblast or GCs within the junctional zone.

300 s essential for maintaining cells within the junctional zone.