ライフサイエンスコーパス: kb

1 THLs were encapsulated with a 8.0 kb plasmid DNA encoding the 3.9 kb human NPC1 open readi

2 ne including regulatory elements within 40.1 kb of DNA 5' and 25 kb of DNA 3' to the gene was used to

3 pair (kb; 95% CI, -66.7 to -7.4 kb) and 57.1 kb (95% CI, -118.1 to 3.9 kb), respectively.

4 me rearrangements at a resolution of about 1 kb.

5 ange reads (>=1 kb) and long-range reads (>1 kb)".

6 re further split into short-range reads (>=1 kb) and long-range reads (>1 kb)".

7 , rs1933683 (OR = 1.34; P = 3.1 x 10-9) is 1 kb downstream of BARX1 at 9q22.32, an essential gene for

8 tes, Pol II decelerates from >2 kb/min to <1 kb/min, which correlates with Spt5 dephosphorylation. Po

9 e-wide analysis of the highest resolution (1 kb) Hi-C data available to date (~48 h with 32 GB peak m

10 stranded DNA (dsDNA) homology donors with ~1 kb homology arms.

11 lotting showed that transcription of 2.4/2.1-kb mRNA coding envelope proteins containing large hepati

12 ome of other eukaryotes) and thousands of ~1-kb minicircles.

13 generate knock-in models containing up to 1-kb inserts when single-stranded DNA (ssDNA) repair templ

14 ing mutation is CFTR c.3718-2477C>T (3849+10 kb C>T), which creates a new 5' splice site, resulting i

15 inguish CN changes with a resolution of <=10 kb.

16 n and hydroxymethylation in regions up to 10 kb from nanogram-level input.

17 t, we identify a single enhancer variant ~10 kb upstream of Lifr associated with chromatin accessibil

18 candidate genes were identified within a 10-kb distance of the most significant SNP.

19 Using available Hi-C data at a 10-kb resolution, we have identified 15,000 reproducible co

20 ng and validated by transformation of a c.10-kb genomic sequence including WTK2 into susceptible comm

21 rategy, grouping six to eight SNPs within 10-kb windows with an average of 0.6 cM (627 kb) between fo

22 nscription unit, but rarely more than 50-100 kb of flanking DNA, even when multiple neighboring genes

23 n band phenotype to WntA and identify a ~100 kb region controlling this variation.

24 Numerous foreign tracts (totaling almost 100 kb, ~ 14% of the mtDNA), including 12 intact genes, were

25 d N50 values and 6.5x coverage in reads >100 kb using three flow cells per sample.

26 ions, partitioned by length (<100 kb or >100 kb) and other characteristics, and 2) individual rare ex

27 and facilitates the expression of long (>100 kb) genes, many of which are important for neuronal func

28 nd duplications, partitioned by length (<100 kb or >100 kb) and other characteristics, and 2) individ

29 nd-generation sequencer to generate over 100 kb of long-range sequencing information with as little a

30 adjacent regions (EARs) spanning roughly 100 kb near all telomeres that escape DSB down-regulation.

31 also found 2,332 variations larger than 100 kb.

32 s of genes for which the presence within 100 kb of an SV breakpoint associates with altered expressio

33 movement genes, 148 of which were within 100 kb of high-confidence BMAL1 binding sites.

34 large (Neb: 22 kb), and very large (Ttn: 106 kb) transcripts in cardiac muscle, and fast and slow ske

35 th <=30 x depth and N50 subread length of 11 kb are highly fragmented, with even low-copy genic regio

36 epressed CXCR7 by binding to an enhancer 110 kb downstream of the gene and expression was restored up

37 re related to the Fabaceae (a total of ~ 110 kb, 15.4%), some of which were shared with L. mirabile.

38 Here, we show that a 114 kb introgressed region containing Hnrnph1 and Rufy1 was

39 riptome analysis of striatal tissue from 114 kb congenics vs Hnrnph1 mutants identified a nearly perf

40 esponding decrease in hnRNP H protein in 114 kb congenic mice.

41 plasmids pCJDM202 (119 kb) and pCJDM67L (116 kb) from C. jejuni strains WP2-202 and OD2-67, respectiv

42 In this study, megaplasmids pCJDM202 (119 kb) and pCJDM67L (116 kb) from C. jejuni strains WP2-202

43 that include an intact CRISPR array and a 12 kb inverted duplication.

44 in a final map-based cloning interval of 12 kb.

45 tSCAN-SMS) to target elements within the ~12-kb cis-region (cis-REs; CREs) of the Oct4 gene locus, as

46 Within this 12-kb interval, the only likely candidate for Rf4 was GRMZM

47 n, long-read sequencing, we identified a 120 kb insertion in the wingless allele.

48 flanked by inverted repeats (IRs) up to 134 kb long.

49 ion, estimated by a median bin length of 146 kb and 11 genes per bin.

50 percholesterolemia deletion ( LDLR delta >15 kb deletion) on CAD risk in one of these cohorts and use

51 sk similar to carriers of the LDLR delta >15 kb mutation, consistent with previous estimates.

52 ,907 assembled viral contigs (>5 kb, mean 15 kb), 97% were found in each sample (by >98% ID metagenom

53 e from 5 to 60 fold, and for recovery of ~15 kb-long sequences with no sequencing artifacts introduce

54 populations, we narrowed down Pl(17) to a 15-kb region flanked by SNP markers C4_5711524 and SPB0001.

55 cal mapping (OM) of long DNA fragments (>150 kb) with next-generation sequencing (NGS) to resolve fCN

56 Cs) and facilitates translocation of an ~150-kb dsDNA genome, followed by acquisition of a pleomorphi

57 /slie) mice, which contain a spontaneous 150-kb deletion in the Ddr2 locus to produce an effective nu

58 The NAHR site was localized to a 160-kb paralog shared between the LCR22A and -D in seven 22q

59 low dependence on linear distance, up to 170 kb.

60 The large size of the ASFV genome (~180 kb) has historically hindered efforts to rapidly obtain

61 ating that this re-targeting, occurring ~182 kb from the gene promoter, is enough to restore the func

62 gene deletions ranged in size from 21 to 183 kb and collectively accounted for 23.4% of its genome.

63 DSBs and the repeats is increased to the 1-2 kb range, while BIR-mediated RMD (BIR/RMD) can act over

64 d to achieve the targeted insertion of a 5.2 kb carotenoid biosynthesis cassette at two genomic safe

65 omoeologs genomic copies ranged from 5.3-6.2 kb with the 7A copy being the largest due to novel inser

66 The most distal 2 kb region in the majority of human subtelomeres contains

67 scripts use poly(A) sites within the first 2 kb of the downstream transcription units.

68 ical mapping, one can identify large SVs (>2 kb) across the genome in one experiment.

69 ntagonistic dynamics over long distances (>2 kb) through transcription-induced DNA supercoiling.

70 of poly(A) sites, Pol II decelerates from >2 kb/min to <1 kb/min, which correlates with Spt5 dephosph

71 Backtracking is most frequent within 2 kb of start sites, consistent with slow elongation early

72 es that conversion of 5mCG to 5hmCG within 2 kb of the transcription start site associates with disti

73 hia coli comprise only short (on average 1.2-kb) Okazaki fragments.

74 Hepatitis E virus (HEV) is a 7.2-kb positive-sense, single-stranded RNA virus containing

75 t to create contact domains, we inserted a 2-kb DNA sequence underlying a tissue-invariant domain bou

76 n rate increases from ~3-5 kb/h up to ~10-20 kb/h in an Rqh1-dependent manner, while Exo1 becomes dis

77 by the capture of long DNA fragments (15-20 kb) by magnetic beads, after enzymatic extension of olig

78 entified a candidate causal variant as a ~20 kb tandem duplication within LYST, spanning exons 30 thr

79 stream elements, such as putative -7 and -20 kb enhancers, were HIF-independent events.

80 applied for the study of mid-range (e.g., 20 kb-2 Mb for human genome) intra-chromosomal contacts; ho

81 Notably, long genes with > 20 kb in length were much more prevalent in the magnoliid g

82 vered unexpectedly high rates of large (> 20 kb) excisions and inversions, while also revealing a sur

83 aled three MafK binding regions (-25 kb, -20 kb, and IRF8 6th intron) within the IRF8 locus.

84 Most (60%) interactions occurred over <20 kb, where chromosome conformation capture-based methods

85 In budding yeast, transcription within 20 kb of telomeres is repressed, in part by the histone-mod

86 gions, as well as one novel genome with a 20-kb deletion, resulting in the loss of multiple lytic and

87 on as boundary elements at the edges of a 20-kb silent heterochromatic domain where nucleosomes are m

88 span a region of 200 kb, with conspicuous 20-kb stretches of highly conserved sequences among the fou

89 an act over a long distance (e.g., ~ 100-200 kb) when the DSB is close to one repeat.

90 including an association peak spanning a 200 kb region downstream from TGFB2.

91 .IMPORTANCE "Giant" phages with genomes >200 kb are being isolated in increasing numbers from a range

92 ined the burden of large and rare CNVs (>200 kb, <1% MAF) as well as known schizophrenia-associated C

93 nvestigated loop domains (median size of 200 kb) and nonloop domains (median size of 9 kb).

94 cutive palindromes that span a region of 200 kb, with conspicuous 20-kb stretches of highly conserved

95 resulted in targeted deletions of up to ~200 kb in length.

96 rongest correlations are observed within 200 kb of promoters.

97 on on chromosome 8 with an approximately 200-kb overlapping section.

98 y juxtaposes 3' IgHRR enhancers with the 200-kb upstream Smu to generate a CSR centre (CSRC).

99 depth and with N50 subread lengths of 11-21 kb.

100 We previously identified a 210 kb region on chromosome 11 (50.37-50.58 Mb, mm10) contai

101 Strain S22 harbors a 22 kb circular plasmid which encodes putative iron and hydr

102 produce medium (Nrap: 5 kb), large (Neb: 22 kb), and very large (Ttn: 106 kb) transcripts in cardiac

103 chlear aplasia, we identified homozygous 221-kb and 338-kb deletions in a noncoding region on chromos

104 f interlocked DNA molecules: a few dozen ~23-kb maxicircles (homologs of the mitochondrial genome of

105 e virus has a large genome, greater than 230 kb, and functional annotation of these genes is importan

106 cf1 binding sites in the Blimp1 gene at a 24-kb upstream and an intron-3 element.

107 tion of the intron-3 element, but not the 24-kb upstream element, compromised production of T(FH) cel

108 id infection of Salmonella phage SPN3US (240-kb genome) using third-generation mass spectrometry.

109 The 240-kb Salmonella phage SPN3US genome encodes 264 gene produ

110 a ~70-copy tau-transgene insertion in a 244 kb deletion in Fgf14, a ~7-copy tTA-transgene insertion

111 but at relatively low resolutions (e.g. 5-25 kb), which is substantially coarser than the resolution

112 ory elements within 40.1 kb of DNA 5' and 25 kb of DNA 3' to the gene was used to generate founder mi

113 sis revealed three MafK binding regions (-25 kb, -20 kb, and IRF8 6th intron) within the IRF8 locus.

114 nding sites that are often offset by 5 to 25 kb.

115 onary young (~530,000 years) cis-acting 2.25-kb LTR retrotransposon insertion reducing expression of

116 odules advance replication timing over a 250 kb region through the cooperation with one endogenous or

117 chemotype) are contained within large (>250 kb) retrotransposon-rich regions that are highly nonhomo

118 amelogenin X (Amelx-iCre) with a large (250-kb) bacterial artificial chromosome DNA vector.

119 gle-stranded, positive-sense RNA genome (~27 kb) and has a complex replication strategy that includes

120 A 103.3 kb deletion NC_006610.3CFA28:g.23380074_23483377del, con

121 that range from 4.6 kb (monopartite) to 5.3 kb (bipartite) in size.

122 Here, we find that large (>7.3 kb) DNA methylation nadirs (termed "grand canyons") can

123 nthetase (PerA), which is encoded by the 8.3 kb gene perA, though this has not been conclusively prov

124 The >3 kb ORF overlap on opposite strands, unprecedented among

125 f a small part of the BCO2 coding region (<3 kb) in S. discolor and S. vitellina, including an amino

126 iruses with a remarkably simple genome of ~3 kb, encoding only a highly conserved RNA-dependent RNA p

127 ified PGR-regulated genes bound PGR within 3 kb of the gene and PGR binding sites were highly enriche

128 proposed salmon flavivirus (SFV) has a 10.3-kb genome that encodes a rare dual open reading frame, a

129 s of serotype M28 GAS isolates harbor a 36.3-kb mobile genetic element of apparent group B Streptococ

130 In this study, we identified a polymorphic 3-kb region within LILRB1 intron 1 that is epigenetically

131 led protospacer insertion in a supercoiled 3-kb plasmid harboring a minimal CRISPR locus derived from

132 CRISPR-mediated deletion of the 3-kb region lowers LILRB1 expression in human NKL cells.

133 utionarily conserved sites located 94 and 30 kb from the mouse Lef1 promoter.

134 Resolution was measured as ~30 kb, close to single-gene.

135 ted at two chromosomal sites separated by 30 kb, these two modules come into close physical proximity

136 Studying the DNA sequence of the distal 30 kb of the majority of murine q-arm subtelomeres indicate

137 ration with one endogenous origin located 30 kb away.

138 isition of a single DNA segment less than 30 kb long.

139 accumulation of Ser5P in the first 20 to 30 kb coincided with reductions in histone H2B ubiquitylati

140 oximal regions and within the first 20 to 30 kb of gene bodies, respectively.

141 nd shed light on how the virus packs its ~30-kb-long single-segmented RNA in the ~80-nm-diameter lume

142 The small ~30-kb ssRNA genome of coronaviruses makes them adept at cro

143 In Primula, the S locus is a roughly 300-kb hemizygous region containing five predicted genes.

144 obarcoding of more than 8 million 20- to 300-kb genomic DNA fragments.

145 ion instead requires the Batf3-dependent +32-kb Irf8 enhancer.

146 sia, we identified homozygous 221-kb and 338-kb deletions in a noncoding region on chromosome 8 with

147 he two QTL detected on Omy1 to 96 kb and 347 kb respectively, with the second QTL explaining up to 14

148 lier that these CREs, located at -44 and -35 kb upstream of the promoter, have strong cell-type-selec

149 and refine its location that extends over 35 kb and includes the first intron, the first two exons an

150 substantial recruitment of RNAPII to the -35 kb element and identify CEBPbeta as a key activator of a

151 Pl(19) was delimited to a 35-kb region and was approximately 1 Mb away from Pl(17), f

152 e linkage disequilibrium (LD) block in a 350 kb interval harboring CRKL.

153 eleted region started from approximately 350 kb downstream of GDF6, which codes for growth and differ

154 erage length of a gene transcript to be 3.37 kb, we estimated that 29 613 lines are required to achie

155 nstruction of plasmids up to 16 genes and 38 kb with high efficiency (> 80%).

156 decreased expression of SMARCA2, located 388 kb away.

157 , we show that targeted integration of a 3.4 kb AT-DRS derived from the human CFS FRA16C into a chrom

158 >1300 X chromosomes integrated with the 3.4 kb AT-DRS revealed recurrent gaps and breaks at the inte

159 dly higher inverted repeat (IR) size of 37.4 kb, suggesting large-scale inversion of 13.8 kb within t

160 est positive-sense RNA genomes of 2.2 to 4.4 kb with a single open reading frame (ORF) encoding an RN

161 .1 kilo-base pair (kb; 95% CI, -66.7 to -7.4 kb) and 57.1 kb (95% CI, -118.1 to 3.9 kb), respectively

162 able of moving along DNA for distances of >4 kb at a rate of ~200 bp per second at room temperature.

163 increases beta-catenin occupancy at a site 4 kb upstream to Lef1.

164 The -4 kb upstream site falls in a segmental duplication of a n

165 of HNF4alpha, which is known to enhance 2.4-kb mRNA transcription, was regulated by Rab5B.

166 maintains the obligate chiasma despite a 5.4-kb deletion in MSH5B rendering it nonfunctional, which o

167 ntly by various functional annotations and 4-kb sliding windows.

168 dence reporter system under the control of 4-kb promoter of human Klotho in stable HEK293 cells and i

169 (a human lymphoblastoid cell line), (ii) 40-kb resolution whole-genome Hi-C data from IMR90 (human l

170 loped, which can move DNA fragments up to 40-kb directly and integrate a 73.7-kb BGC to the genome of

171 e in natural populations, (2) at the 200-400 kb scale, recombination rate appears to vary largely gen

172 rate and structural variation at the 200-400 kb scale.

173 icity in Amaranthus palmeri: a massive, ~400-kb extrachromosomal circular DNA (eccDNA) that harbors t

174 Instead, a +41-kb Irf8 enhancer, previously thought to be active only i

175 t site of the transcription factor Irf8 (+41-kb Irf8 enhancer), but its maturation instead requires t

176 Thus, cryptic activation of the +41-kb Irf8 enhancer in dendritic cell progenitors is respon

177 udy of 45 common human inversions of 0.1-415 kb.

178 We achieved roughly 63x coverage, 42-kb read N50 values and 6.5x coverage in reads >100 kb us

179 es of two closely related megaplasmids (>420 kb) carrying large arrays of antibiotic resistance genes

180 Reporters driven by MYC ESEs 525 kb and 428 kb upstream of MYC (525ESE and 428ESE) had very high act

181 n (PCPA) and loss of expression of long (>45 kb) genes, a substantial proportion of which participate

182 the second enhancer in a chain, 96 kb vs. 45 kb, respectively.

183 We identified a deletion of a 45-kb genomic region in the most recent First Pandemic stra

184 We biolistically transformed linear 48-kb phage lambda and two different circular plasmids into

185 of chromosomal DNA ranging from 181 bp to 49 kb.

186 hree putative FOXF1 binding sites in the 1.5 kb ATX promoter which demonstrated transcriptional repre

187 reading frame, under the influence of a 1.5 kb platelet derived growth factor B (PDGFB) promoter.

188 Bio Sequel reads, with a mean length of 11.5 kb, helped to resolve repetitive elements and generate s

189 At 15.5 kb in size and with only 19 genes, they are among the mo

190 n of a nearly identical intronic region +2.5 kb downstream of the TSS, and this duplication occurred

191 ariants is a rare, previously unreported 2.5 kb exonic deletion in COL4A3.

192 ells, the resection rate increases from ~3-5 kb/h up to ~10-20 kb/h in an Rqh1-dependent manner, whil

193 d that MRLR achieved a median resolution 4.5 kb.

194 mal infection process are located within a 5 kb region directly upstream of the NIN start codon in Me

195 We have identified an enhancer ~5 kb upstream of the IFNK gene driving its expression in k

196 We describe 2 large (>5 kb) recombination events, one of which arose in its curr

197 Of 19,907 assembled viral contigs (>5 kb, mean 15 kb), 97% were found in each sample (by >98%

198 We identified 46 127 viral populations (>=5 kb), which augments the known viruses from ETSP by 10-fo

199 tructural genes that produce medium (Nrap: 5 kb), large (Neb: 22 kb), and very large (Ttn: 106 kb) tr

200 eQTL density in the +/-5 kb adjacent region of a given SNP was also positively as

201 Upon injection, donor DNA (1 to 5 kb) is released from the plasmid by Cas9.

202 SP3-FL-UnaG) with a genetically modified 1.5-kb segment 7 dsRNA encoding full-length nonstructural pr

203 We discovered a 2.5-kb deletion (del2.5) overlapping the 3' untranslated reg

204 EED, SUZ12, AEBP2 and RBBP4), bound to a 2.5-kb DNA with an apparent dissociation constant ($K_{\rm{D

205 attB-containing donor plasmids or linear 2.5-kb PCR fragments.

206 l eight centromeres in M. sympodialis as 3-5-kb long kinetochore-bound regions that span an AT-rich c

207 obustly silence transcription, whereas a 5.5-kb Xist transgene robustly silenced transcription and re

208 e FitHiC2 protocol to three use cases: (i) 5-kb resolution Hi-C data of chromosome 5 from GM12878 (a

209 astoma stem cells (GSCs) by generating sub-5-kb resolution 3D genome maps by in situ Hi-C.

210 Contact maps at sub-5-kb resolution allow identification of individual DNA loo

211 -inferred 3 D structures (at both 500 and 50 kb resolutions) using multiple criteria and compared the

212 her kinase, gamma-H2AX spreads as far as ~50 kb on both sides of the lesion within 1 h; but the kinet

213 ng noncoding RNA (lncRNA) Pvt1, expressed 50 kb downstream of Myc, which becomes induced by DNA damag

214 uclease activity of MRN, to single long (~50 kb) DNA molecules using nanofluidic channels and compare

215 with the cleavage sites that generate the 50 kb DNA fragments during the first stages of programmed c

216 esults in the formation of loops of up to 50 kb.

217 enome at chromosome, three megabase, and 500 kb scales.

218 ducted a genome-wide analysis of large (>500 kb), rare (<1%) germline copy number variants (CNVs) in

219 hizophrenia, CNVs with large deletions >=500 kb, and total CNV burden.

220 f known genome-wide significant loci (+/-500 kb).

221 e also down-regulated, over a region of ~500 kb on chromosome 3p21.

222 g the 20 PDAC susceptibility regions (+/-500 kb) previously identified by GWAS, the genomic regions f

223 ion between PDAC and genomic regions (+/-500 kb) surrounding established common susceptibility varian

224 significant loci on genes located within 500 kb of each locus.

225 elements located within an approximately 500-kb region of the genome in humans and that its disruptio

226 , a ~7-copy tTA-transgene insertion in a 508 kb deletion that disrupts another five genes, in additio

227 Reporters driven by MYC ESEs 525 kb and 428 kb upstream of MYC (525ESE and 428ESE) had ve

228 lete), ranging from 159 kilobase (kb) to 527 kb in length, were found to encode the pmoC gene, an enz

229 candidate regions lead us to identify a 1.6 kb region that, when deleted, results in a near total di

230 Deletions in the 16.6 kb mitochondrial genome have been implicated in numerous

231 yet they package genomes that range from 4.6 kb (monopartite) to 5.3 kb (bipartite) in size.

232 ing data revealed an open chromatin region 6 kb downstream of the transcriptional start site of Cebpe

233 nscriptional units in a single vector (~10.6-kb synthetic operon).

234 archaeota Virus 1 (NAV1), consists of a 35.6-kb circular DNA genome coding for 52 proteins.

235 ntified binding of CEBPA and CEBPE to the +6-kb enhancer, which suggests their role in regulating the

236 cells expressing guide RNA targeting the +6-kb region.

237 n direct orientation (TDDOs) ranging from 60 kb to 1.44 Mb.

238 etrotransposons L1P1 and L1PA1 upstream (-60 kb) of OPRM1.

239 one of its common genetic etiologies, a 600 kb reciprocal deletion/duplication at 16p11.2.

240 rs.SIGNIFICANCE STATEMENT The recurrent ~600 kb deletion at 16p11.2 (BP4-BP5) is one of the most comm

241 The genomic sequence of CpMMS19 is 62 kb, consisting of 20 exons and 19 introns.

242 both populations delimited the gene to a 620 kb region where 19 genes were annotated.

243 10-kb windows with an average of 0.6 cM (627 kb) between focal points.

244 risk-altering haplotypes overlapping the 648 kb locus (three protective, and four risk (peak odds rat

245 TSPV1 packages an 18.65-kb linear double-stranded DNA (dsDNA) genome with 31 ope

246 We observe an average CNV burden of ~650 kb, identifying a total of 11,314 deletion, 5625 duplica

247 analysis identified a syntenic region of 660 kb in Ae. tauschii with 18 annotated genes and a synteni

248 nt junction fragment indicated that these 67 kb heterozygous duplications were likely mediated by non

249 DRAIC is a 1.7 kb spliced long noncoding RNA downregulated in castratio

250 D sequences (after size selection of 3.7-5.7 kb) which were screened against an NCBI 16S rRNA gene da

251 nded-circular DNA donor vector (lsscDNA, 6.7 kb) containing two loxP sites in cis and 900-700 bp 5'/3

252 ts up to 40-kb directly and integrate a 73.7-kb BGC to the genome of S. mutans UA159 via three rounds

253 Persistent accumulation of the oncogenic 7-kb long noncoding RNA MALAT1 is dependent on an unusuall

254 00 kilobases (kb), including a genome of 735 kb, which is-to our knowledge-the largest phage genome t

255 study 20 inversions ranging from 3.1 to 742 kb flanked by inverted repeats (IRs) up to 134 kb long.

256 Here, we show that TS is detected up to 75 kb downstream of a collapsed replication fork and can be

257 andidate enhancer variants located up to 750 kb from their target genes, VEGFC, FGD6, and KIF26B.

258 ogeny surviving >15 mg/kg CQ identifies a 76 kb region in chromosome 1 including pvcrt, an ortholog o

259 The causative mutation is a 78-kb tandem duplication of PLAU.

260 The knock-in efficiency for a 1.8 kb gene was contrasted when combining microinjection of

261 cy with relatively small DNA fragments (<1.8 kb).

262 io) RSII platform (80x, N50 read length 11.8 kb) and generated de novo genome assembly to the level o

263 kb, suggesting large-scale inversion of 13.8 kb within the expanded IR regions.

264 ant, a gene orthologous to MMS19 with a 36.8 kb deletion co-segregating with the diminutive mutant.

265 tion of rs139401390 located to a region 58.8 kb upstream of renalase (RNLS) with eGFR was detected in

266 -nucleotide polymorphism (SNP) rs56151658 (8 kb from the promoter of HLA-DQB1) was most significantly

267 single-stranded RNA with a genome of ~7 to 8 kb, and were designated as Ruddy turnstone astrovirus (R

268 n wheat (Triticum aestivum), as well as an 8-kb deletion in MSH4D in hexaploid wheat, predicted to cr

269 increased nascent leading-strand size to ~80 kb, while lagging-strand Okazaki fragments remained unaf

270 ed to reduce the P. aeruginosa genome by 837 kb (13.5%).

271 cent to the distal PR-binding site (PRBS) 87 kb upstream of the RANKL transcription start site.

272 d with a 8.0 kb plasmid DNA encoding the 3.9 kb human NPC1 open reading frame, under the influence of

273 -7.4 kb) and 57.1 kb (95% CI, -118.1 to 3.9 kb), respectively.

274 mechanism of direct association with AR 6.9 kb 3'UTR and transcript stabilisation.

275 cription factor binding sites separated by 9 kb.

276 All amplicons of >=9 kb were sequenced and analyzed through a bioinformatic p

277 xO1 binds to three distinct sites located ~9 kb upstream of the serpinb1 gene in primary mouse hepato

278 h large internal deletions were excluded (<9 kb).

279 00 kb) and nonloop domains (median size of 9 kb).

280 d using transgenic mice, we identified a 2.9-kb regulatory element at the Isl1 locus that was active

281 ariants (r(2) > .60) spanning as much as 900 kb.

282 oter than the second enhancer in a chain, 96 kb vs. 45 kb, respectively.

283 itions of the two QTL detected on Omy1 to 96 kb and 347 kb respectively, with the second QTL explaini

284 Ablation of the Smpd3 locus as part of a 980-kb deletion on chromosome 8 in the fro/fro mutant, gener

285 Nested 0.5- and 1.0-kilobase (kb) deletion fragments of the ITPR3 promoter were inhibi

286 18 are complete), ranging from 159 kilobase (kb) to 527 kb in length, were found to encode the pmoC g

287 sional (3D) genome structure at 20-kilobase (kb) resolution, achieved by applying our recently develo

288 inter-sister connections every ~35 kilobase (kb).

289 ar the breakpoints of large (>100 kilobases (kb)) inversions but not smaller events.

290 mes with lengths of more than 200 kilobases (kb), including a genome of 735 kb, which is-to our knowl

291 ven at genomic distances below 25 kilobases (kb) where both tend to be high.

292 ds with an average length of 13.5 kilobases (kb).

293 ever, the size of the genome (5.2 kilobases [kb]) surpasses the optimal packaging capacity of the vec

294 e crossover regions span tens to hundreds of kb, which is not sufficient resolution to accurately ide

295 th a decrease in aTL of 37.1 kilo-base pair (kb; 95% CI, -66.7 to -7.4 kb) and 57.1 kb (95% CI, -118.

296 0 (Mt4.0), 0.44 Tnt1 insertions occurred per kb, and 19 583 genes contained Tnt1 with an average of 3

297 er kb between Wm82 and Lee, and 4.7 snps per kb between these lines and G. soja.

298 7 single-nucleotide polymorphisms (snps) per kb between Wm82 and Lee, and 4.7 snps per kb between the

299 onservation (20 nucleotide substitutions per kb).

300 s chromatin contact maps at subkilobase (sub-kb) resolution with low background noise.