ライフサイエンスコーパス: keratitis

1 itis, postoperative aspergillosis and fungal keratitis.

2 been considered as an idiopathic autoimmune keratitis.

3 eristic skin lesions, hearing deficiency and keratitis.

4 rticosteroids and oral acyclovir for stromal keratitis.

5 developing world for treatment of bacterial keratitis.

6 diseases, such as blinding herpetic stromal keratitis.

7 l microscopy performed at the acute stage of keratitis.

8 oriconazole on clinical outcomes in Fusarium keratitis.

9 oplasty (PPK) for herpes simplex virus (HSV) keratitis.

10 detachment, stromal necrosis, and infectious keratitis.

11 laments and acanthamoeba cysts in infectious keratitis.

12 tis, corneal neovascularization, and stromal keratitis.

13 ologist from patients suspected of microbial keratitis.

14 nderwent diagnostic testing for Acanthamoeba keratitis.

15 rpes simplex virus keratitis or Acanthamoeba keratitis.

16 he development of HSV-1-induced neurotrophic keratitis.

17 were key predisposing factors for microbial keratitis.

18 euritis is first described in M. haemophilum keratitis.

19 ections model and in vivo model of bacterial keratitis.

20 n early development of severe herpes stromal keratitis.

21 different from that of herpes simplex virus keratitis.

22 ngals in the treatment of filamentous fungal keratitis.

23 for novel therapeutics against P aeruginosa keratitis.

24 expenditure for the management of infectious keratitis.

25 contact lens use are associated with MDR-PA keratitis.

26 contact lens use were associated with MDR-PA keratitis.

27 lymicrobial keratitis and 60 cases of fungal keratitis.

28 intervention for the treatment of microbial keratitis.

29 y elevated in neutrophils from patients with keratitis.

30 icans infection in an animal model of fungal keratitis.

31 to treat, with a poorer outcome than fungal keratitis.

32 can be targeted for preventing P. aeruginosa keratitis.

33 adosporium keratitis, a rare cause of fungal keratitis.

34 s compared with drug-sensitive P. aeruginosa keratitis.

35 ical moxifloxacin hydrochloride in bacterial keratitis.

36 vitro and in a model of Aspergillus-induced keratitis.

37 ication to aid in the diagnosis of microbial keratitis.

38 SMG and other FARs for antibiotic-resistant keratitis.

39 l management of M. haemophilum scleritis and keratitis.

40 Only 1 case presented with scleritis with keratitis.

41 ening the duration of herpes simplex stromal keratitis.

42 s with moderate-to-severe filamentous fungal keratitis.

43 obial pathogens with relevance to infectious keratitis.

44 ccurred within ocular glands following HSV-1 keratitis.

45 udomonas aeruginosa, subsequent to microbial keratitis.

46 methicillin-resistant Staphylococcus aureus keratitis.

47 the vast majority of patients with Moraxella keratitis.

48 ceptible to infection secondary to microbial keratitis.

49 apeutic approach for the treatment of fungal keratitis.

50 cleritis (1.8%), and 3 cases of interstitial keratitis (0.9%).

51 vitreous amyloid (26/26, 100%), neurotrophic keratitis (2/26, 8%), glaucoma (5/26, 19%), and tortuous

52 in young people; and sequellae of infectious keratitis (20%).

53 Of the 70 study subjects with fungal keratitis, 25 of 69 (36%) remained culture positive at d

54 (9 eyes), corneal melt (5 eyes), infectious keratitis (3 eyes), endophthalmitis (3 eyes), GDD erosio

55 : 1.58%), 7 (5.79%) for suspected infectious keratitis, 3 (2.48%) for corneal melting, and 1 (0.83%)

56 hirty-nine culture-proven cases of Moraxella keratitis (39 eyes) diagnosed and treated between Januar

57 iral medications for presumed herpes simplex keratitis; 4 patients underwent diagnostic testing for A

58 llow-up for uveitis were elevated IOP (75%), keratitis (59%), dry eyes (34%), posterior synechiae (34

59 ngal agents, we were faced with Cladosporium keratitis, a rare cause of fungal keratitis.

60 Acanthamoeba keratitis, a rare eye disease primarily affecting contac

61 oil amoebae Acanthamoeba causes Acanthamoeba keratitis, a severe sight-threatening infection of the e

62 n to corneal resistance.IMPORTANCE Microbial keratitis accounts for up to 700,000 clinical visits ann

63 rvival, and determining factors of microbial keratitis after penetrating keratoplasty (PK).

64 rds of all patients diagnosed with microbial keratitis after penetrating keratoplasty at the National

65 Infectious keratitis after penetrating keratoplasty leads to a high

66 Amoebic keratitis (AK) is a potentially blinding infection, the

67 Acanthamoeba keratitis (AK) is a very painful and vision-impairing in

68 diagnostic criteria to diagnose Acanthamoeba keratitis (AK) using polymerase chain reaction (PCR) as

69 the sight threatening infection Acanthamoeba keratitis (AK).

70 d by the investigator to be vaccine related (keratitis; amnesia).

71 ate to placebo in the treatment of bacterial keratitis among 500 patients with culture-positive ulcer

72 included 21 patients with filamentous fungal keratitis and 24 patients with bacterial keratitis (as c

73 Fifty study participants with prior fungal keratitis and 50 with prior bacterial keratitis were enr

74 re 34 eyes of 34 patients with polymicrobial keratitis and 60 cases of fungal keratitis.

75 steurella multocida include: endophtalmitis, keratitis and corneal ulcers, Parinaud's oculoglandular

76 of infection, including necrotizing stromal keratitis and herpes simplex encephalitis.

77 rophils was examined in patients with fungal keratitis and in uninfected individuals in southern Indi

78 present in 2 patients mimicking interstitial keratitis and limbal stem cell deficiency.

79 as an adjunctive therapy to treat microbial keratitis and other mucosal infections.

80 ghts the need for nationwide study on fungal keratitis and precise identification of the causative fu

81 dy was to determine the prevalence of fungal keratitis and spectrum of fungi implicated in causing th

82 Patients with non-Nocardia keratitis and those having no topical antibiotic use bef

83 filamentous fungi in patients with microbial keratitis and to evaluate the effect of observer's imagi

84 plasma IL-17 and IL-23 between patients with keratitis and uninfected individuals; however, combined

85 from randomization to resolution of stromal keratitis and uveitis was significantly shorter in the s

86 ye Hospital, Pondicherry, India, with fungal keratitis and visual acuity worse than 20/70 received to

87 tics remain the best treatment for bacterial keratitis, and a recent review found all commonly prescr

88 perforates) model of Pseudomonas aeruginosa keratitis, and also significantly downregulates HMGB1 ex

89 lative rates of RD or RD surgery, infectious keratitis, and CME were 1.0%, 0.8%, and 4.1%, respective

90 ficantly different from herpes simplex virus keratitis, and further studies using this model should g

91 istory of prior ocular surgery or infectious keratitis, and unreliable corneal tomography.

92 uce the morbidity associated with infectious keratitis are likely to be multidimensional, with adjuva

93 gal keratitis and 24 patients with bacterial keratitis (as controls).

94 inguish between bacterial, fungal, and viral keratitis, as the treatments are quite different.

95 are frequently associated with Acanthamoeba keratitis, as well as in Acanthamoeba coinfections.

96 kic bullous keratopathy (North America), and keratitis (Asia).

97 from 267 patients presenting with microbial keratitis at a referral cornea clinic in South India.

98 for cases of severe, progressive infectious keratitis before performing a therapeutic keratoplasty.

99 herpes simplex keratitis, then Acanthamoeba keratitis before referral.

100 Bacterial keratitis (BK) is an ocular disorder associated with poo

101 or a few weeks delayed resolution of stromal keratitis but had no detrimental effect as assessed by v

102 currence of any type of herpes simplex virus keratitis by approximately half.

103 promotes better resolution of P. aeruginosa keratitis by decreasing levels of proinflammatory mediat

104 All cultured infectious keratitis cases from July 1, 2008, through December 31,

105 fungi are commonly recovered from microbial keratitis cases with a disproportionally high incidence.

106 Twenty-three episodes of MDR-PA keratitis (cases) and 67 episodes of drug-sensitive P. a

107 We report an aggressive fungal keratitis caused by a putatively novel species of Lophot

108 , IL-6 and IL-8 cytokines were quantified in keratitis caused by Gram-negative bacteria.

109 single transient episode of HSV-1 epithelial keratitis causes long-term changes in the corneal microe

110 healing problems (sterile infiltrate, herpes keratitis, central haze, and stromal scar).

111 1 (HSV-1) is a leading cause of neurotrophic keratitis characterized by decreased corneal sensation b

112 L) in patients with quiescent herpes simplex keratitis compared with control patients without ocular

113 Outcomes are worse in MDR-PA keratitis compared with drug-sensitive P. aeruginosa ker

114 Symptoms of fungal keratitis consist of blurred vision, redness, tearing, p

115 67 episodes of drug-sensitive P. aeruginosa keratitis (controls) were identified.

116 ases of infectious keratitis, non-infectious keratitis, corneal dystrophy or degeneration, and cornea

117 hthalmia or anophthalmia, retinal dysplasia, keratitis, corneal neovascularization, cataracts, and ca

118 in the murine model of herpes simplex virus keratitis, corneal pathology and lymphangiogenesis are a

119 serious recurrent disease, including stromal keratitis, corneal scarring, blindness, and encephalitis

120 d the causes were refractive errors (47.1%), keratitis/corneal opacity (16%), amblyopia (14.3%), ocul

121 th a previous episode of fungal or bacterial keratitis, correctable bilateral visual impairment was c

122 hthalmitis, choroidal hemorrhage, infectious keratitis, cystoid macular edema [CME], retinal detachme

123 Fungal keratitis developed in 4 cases (5.6%), and all patients

124 y-two culture-proven (52 eyes) cases of MRSA keratitis diagnosed and treated at the University of Pit

125 therapy for recalcitrant deep stromal fungal keratitis did not improve outcomes.

126 Viral keratitis differs from bacterial and fungal cases in tha

127 -2002, the leading risk factor for microbial keratitis during 2008-2012 was contact lens use, and the

128 Episodes of drug-sensitive P. aeruginosa keratitis during the same period were taken as controls.

129 des in 52 eyes of culture-positive microbial keratitis during the study period.

130 Both transmission and disease, such as keratitis, encephalitis, and neurodegeneration, have bee

131 s, the linear form of Thygeson's superficial keratitis, epithelial regeneration line, Acanthamoeba ke

132 M. haemophilum can cause scleritis and keratitis, even in immunocompenent host.

133 nts with bacterial, fungal, viral, or immune keratitis featuring negative Acanthamoeba PCR results (c

134 In previous studies of fungal keratitis (FK) from temperate countries, yeasts were the

135 but few studies have analysed this in fungal keratitis (FK).

136 ts experience a single episode of epithelial keratitis followed by re-establishment of a clear cornea

137 tive culture result reduced the incidence of keratitis from 15.8% in untreated cases to 1.9% in treat

138 rease in the rate of orthokeratology-related keratitis from 9.9% to 19.1% (P = .011).

139 Ninety episodes of P. aeruginosa keratitis from a tertiary care eye institution from 2007

140 f the risk of potentially blinding microbial keratitis from contact lens wear.

141 Although there are several reports on fungal keratitis from developing and developed countries, funga

142 Out of 153 cases of microbial keratitis, fungi were recovered from 69 patients giving

143 e polymicrobial group compared to the fungal keratitis group (39.3% vs 73.7%, P = .0045).

144 equently seen in the Acanthamoeba and fungal keratitis group (8/16) and they were often yellowish wit

145 of 152 individuals whose fungal or bacterial keratitis had been diagnosed 4 years prior and had been

146 , combining medical subject headings (MESH) "Keratitis, Herpetic/" AND "Acyclovir/" limiting by the k

147 lude the blindness-inducing herpetic stromal keratitis, highly debilitating and lethal herpes simplex

148 s to protect against HSK.IMPORTANCE Herpetic keratitis (HK) is the leading cause of blindness by an i

149 or to idoxuridine (IDU) in treating herpetic keratitis (HK) presenting as dendritic and geographic ul

150 infected corneas in a murine model of fungal keratitis; however, the ability to inhibit hyphal growth

151 th a unilateral and relapsing herpes simplex keratitis (HSK group) that was quiescent during evaluati

152 Ocular herpes simplex keratitis (HSK) is a consequence of viral reactivations

153 Herpes stromal keratitis (HSK) is a corneal chronic inflammatory condit

154 Herpes simplex keratitis (HSK), caused by herpes simplex virus type 1 (

155 inflammatory condition called herpes stromal keratitis (HSK), which involves the loss of corneal sens

156 tructive inflammatory disease herpes stromal keratitis (HSK).

157 n the development of severe herpetic stromal keratitis (HSK).

158 lesions in a disease called herpetic stromal keratitis (HSK).

159 eye disease in patients with herpes stromal keratitis (HSK).

160 Mutations of Cx26 associated with the keratitis ichthyosis deafness syndrome (N14K, A40V and A

161 Keratitis-ichthyosis-deafness (KID) syndrome is a severe

162 Keratitis-ichthyosis-deafness (KID) syndrome is an ectod

163 f suspected RM in the skin of a patient with keratitis-ichthyosis-deafness (KID) syndrome.

164 ess associated with skin disorders, like the Keratitis-Ichthyosis-Deafness syndrome (KID).

165 lesions can also appear in individuals with keratitis-ichthyosis-deafness syndrome and finding somat

166 ed regarding the risk of having a child with keratitis-ichthyosis-deafness syndrome.

167 own to cause the severe multisystem disorder keratitis-ichthyosis-deafness syndrome.

168 pical antibiotics for treatment of bacterial keratitis in areas of the world where use of effective t

169 The long-term outcomes with PPK for HSV keratitis in children provide improvement in BCVA when n

170 cause of sporadic encephalitis and blinding keratitis in developed countries.

171 m developing and developed countries, fungal keratitis in Ethiopia is poorly known.

172 ydroxamic acid (SAHA) on experimental fungal keratitis in mice.

173 SAHA was able to inhibit experimental fungal keratitis in mouse by suppressing TLR4 and inflammatory

174 auses an early development of herpes stromal keratitis in NK1R(-/-) mice.

175 tis is one of the major causes of infectious keratitis in tropical countries.

176 reducing the immune response associated with keratitis include topical corticosteroids.

177 Main clinical risk factor for keratitis included contact lens wear (79%).

178 l tissue model representing clinical amoebic keratitis infection.

179 e strains (12/15) were recovered from equine keratitis infections; however, strains of F. keratoplast

180 ily, causes herpes labialis (cold sores) and keratitis (inflammation of the cornea).

181 Infectious keratitis is a major global cause of visual impairment a

182 Amoebic keratitis is a potentially blinding eye infection caused

183 Vaccinia virus (VACV) keratitis is a serious complication following smallpox v

184 Acanthamoeba keratitis is a serious vision-threatening disease.

185 on of the nature of the pathogen that causes keratitis is achieved via microbial culture screening, w

186 Fungal keratitis is an important cause of corneal blindness all

187 The diagnosis of keratitis is based on visual exam, tissue cytology, and

188 Pseudomonas aeruginosa keratitis is characterized by severe corneal ulceration.

189 Fusarium keratitis is common and often results in poor outcomes.

190 eal diseases, but the pathogenesis of fungal keratitis is not fully understood and therefore the trea

191 nvolvement of ocular glands during microbial keratitis is not readily appreciated, and treatment opti

192 Fungal keratitis is one of the leading causes of blindness of i

193 Fungal keratitis is one of the major causes of infectious kerat

194 n the basis of these results, vaccinia virus keratitis is significantly different from herpes simplex

195 basis of our results, the pathology of VACV keratitis is significantly different from that of herpes

196 nas aeruginosa, a leading cause of bacterial keratitis, is facilitated by the bacterial Psl exopolysa

197 Deletion of prtS in clinical keratitis isolate K904 reduced, but did not eliminate, c

198 Ninety-nine percent of P aeruginosa keratitis isolates from SCUT produced Psl EPSs, and 100%

199 protease-positive strains was observed among keratitis isolates than among conjunctivitis isolates.

200 The ability of P aeruginosa keratitis isolates to form biofilms in vitro was correla

201 Antimicrobial resistance in the MDR-PA keratitis isolates was least for colistin and imipenem (

202 pecificity for diagnosing filamentous fungal keratitis, its sensitivity is moderate and highly depend

203 vomiting, peripheral sensory neuropathy, and keratitis/keratopathy.

204 ed mice prevented the development of stromal keratitis lesions more effectively than did control iTre

205 r HSV1 infection controlled herpetic stromal keratitis lesions.

206 d a benefit for all corneal ulcers, Fusarium keratitis may benefit from the addition of oral voricona

207 al study, patients with suspected infectious keratitis meeting traditional criteria for diagnostic co

208 iewed all records of patients with microbial keratitis (MK) that were hospitalized in National Taiwan

209 s aureus carriage in patients with microbial keratitis (MK).

210 cessing (NLP) algorithm to extract microbial keratitis morphology measurements from the electronic he

211 , epithelial regeneration line, Acanthamoeba keratitis, mucus plaque keratopathy, medication-related

212 ewly occurred after DSAEK as a result of HSV keratitis (n = 2) or interface infection (n = 2).

213 CoNV was associated with previous microbial keratitis (n = 26), intrastromal corneal ring segments (

214 than once in the dose-escalation phase were keratitis (n=3) and fatigue (n=2).

215 s newly enrolled with diseases of infectious keratitis, non-infectious keratitis, corneal dystrophy o

216 he increased inflammation response in fungal keratitis not only in humans but also in experimental an

217 es with culture-positive deep stromal fungal keratitis not responding to appropriate medical therapy

218 MRSA causes fulminant keratitis often requiring surgical management with poor

219 Ocular bacterial keratitis, often associated with Pseudomonas aeruginosa

220 of miR-155 in Pseudomonas aeruginosa-induced keratitis, one of the most common sight-threatening ocul

221 rficial cornea, such as herpes simplex virus keratitis or Acanthamoeba keratitis.

222 keratopathy, endophthalmitis, and infectious keratitis or corneal ulceration.

223 tment alone in moderate to severe infectious keratitis over a 30-day period.

224 ell deficiency (LSCD) (P = .02), filamentary keratitis (P = .02), subconjunctival fibrosis (P = .02),

225 Four years after treatment for keratitis, participants' presenting vision in the better

226 ompared to patients with bacterial or fungal keratitis, patients with acanthamoeba keratitis were mor

227 Compared to patients with fungal keratitis, patients with polymicrobial keratitis were si

228 the study group was Acanthamoeba and fungal keratitis positive); 5 were positive for Acanthamoeba an

229 Observations: A woman with recurrent keratitis presented with a corneal ulcer, which was cult

230 ere recovered from 69 patients giving fungal keratitis prevalence of 45.1.

231 en reported in case of peripheral ulcerative keratitis (PUK).

232 rneal stroma, and the disease is primarily a keratitis rather than a keratoendotheliitis.

233 High prevalence of fungal keratitis recorded in the present study, highlights the

234 lbicans inoculation had markedly ameliorated keratitis, reduced fungal load, and decreased polymorpho

235 scleral inflammation subsided but later the keratitis relapsed, requiring corneal biopsy.

236 Fungal keratitis remains a challenge for ophthalmologists as th

237 entiated MDSCs in dampening herpetic stromal keratitis resulting from primary ocular HSV1 infection i

238 -associated neovascularization, postherpetic keratitis scarring, lipid keratopathy, and limbal stem c

239 epithelial keratitis without herpes stromal keratitis sequelae, possessed a significant leukocytic i

240 ruginosa inoculation significantly decreased keratitis severity, as evidenced by preserved epithelium

241 NTM keratitis should be considered in the differential diagn

242 EK for failed TPK conducted for Aspergillus keratitis showed better outcomes in terms of graft clari

243 or T cells can be effective to limit stromal keratitis (SK) lesion severity.

244 sult in a chronic immunoinflammatory stromal keratitis (SK) lesion that is a significant cause of hum

245 onas aeruginosa and Staphylococcus aureus in keratitis; Streptococcus viridians, Streptococcus pneumo

246 HD patients with diabetes, LSCD, filamentary keratitis, subconjunctival fibrosis, and a high NIH scor

247 ease of intraocular pressure (IOP), exposure keratitis, subconjunctival hemorrhage, a sore throat, an

248 on also had strong protection against fungal keratitis, suggesting a therapeutic window.

249 reatment broke down the biofilm and reversed keratitis, suggesting future therapeutic strategies for

250 Improvements in keratitis, symptoms, and QoL achieved after CsA CE treat

251 he efficacy of high-dose CsA CE in improving keratitis, symptoms, and QoL for those with severe VKC w

252 SV-1 infections may lead to herpetic stromal keratitis that may advance to corneal blindness.

253 findings for 9 patients with history of HSV keratitis that underwent PPK and were followed in a sing

254 es simplex keratitis, varicella-zoster viral keratitis, the linear form of Thygeson's superficial ker

255 e diagnosed sequentially with herpes simplex keratitis, then Acanthamoeba keratitis before referral.

256 eak of contact lens (CL)-associated Fusarium keratitis, there may have been a rise in CL-associated f

257 P13 activity may contribute to P. aeruginosa keratitis through basement membrane degradation, and its

258 that ocular glands are involved in microbial keratitis through their susceptibility to secondary infe

259 ing HMGB1 for the treatment of P. aeruginosa keratitis to avoid delivery and other issues associated

260 be useful in cases of fungal or acanthamoeba keratitis to determine the depth of infectious elements,

261 We randomized 172 individuals with bacterial keratitis to topical treatment with povidone-iodine or a

262 rganism in culture and culture-proven fungal keratitis treated with natamycin alone were retrieved fr

263 Patients with progressive infectious keratitis unresponsive to standard medical therapy under

264 rm keratopathy, such as prior herpes simplex keratitis, varicella-zoster viral keratitis, the linear

265 y were misdiagnosed as having herpes simplex keratitis versus 59 (41.8%) patients who did not require

266 g trend in NTM keratitis while Microsporidia keratitis was considered as an emerging ocular disease.

267 routes (1mg/ml and 200mg respectively), the keratitis was controlled.

268 The diagnosis of Mycobacterial keratitis was made.

269 While C. albicans keratitis was more severe in the corneas treated with Ch

270 The inhibitory effect of SAHA on mice fungal keratitis was revealed by GMS and H&E staining.

271 Fungal keratitis was significantly associated with farmers (P =

272 Fungal keratitis was statistically associated with trauma (P =

273 Keratitis was the primary indication in Asia (32.3%).

274 ouse model of herpes simplex virus 1 (HSV-1) keratitis, we found that infection of corneas resulted i

275 Patients presenting with stromal keratitis were additionally tested for Acanthamoeba irre

276 imens from the patients and mice with fungal keratitis were detected by immunohistochemistry.

277 Causative organisms of infectious keratitis were either bacterial or fungal.

278 fungal keratitis and 50 with prior bacterial keratitis were enrolled.

279 n=28), fungal (n=15), or Acanthamoeba (n=13) keratitis were included in the study.

280 fungal keratitis, patients with acanthamoeba keratitis were more likely to be younger and to have a l

281 patients with moderate to severe infectious keratitis were randomized to receive either standard tre

282 ungal keratitis, patients with polymicrobial keratitis were significantly older (50.03 +/- 9.81 years

283 Episodes of MDR-PA keratitis were taken as cases.

284 ecovered from patients with confirmed fungal keratitis were used in the experiments.

285 almology Department for clinically suspected keratitis, were cultured on non-nutrient agar examined b

286 ghly plastic and capable of inducing stromal keratitis when adoptively transferred into Rag1(-/-) mic

287 can be considered for treatment of bacterial keratitis when antibiotic treatment is not practical.

288 ns such as herpes and Pseudomonas aeruginosa keratitis where IL-17A exacerbates corneal pathology and

289 rious adverse events (pharyngeal abscess and keratitis), which were not considered drug related by th

290 We found a decreasing trend in NTM keratitis while Microsporidia keratitis was considered a

291 Identifying patients with infectious keratitis who are at risk of experiencing a poor outcome

292 patients with active herpes simplex stromal keratitis who had not received any corticosteroids for a

293 nty-three eyes of 73 patients with microbial keratitis who underwent ultrasound to evaluate for endop

294 dophthalmitis in our patients with microbial keratitis who underwent ultrasound was 20.5%.

295 Patients with microbial keratitis, who were older and pseudophakic, were prone t

296 Polymicrobial keratitis with fungus and bacteria was more common and m

297 One of them was immunocompetent host and had keratitis with radial keratoneuritis as a presenting sig

298 Consecutive cases of microbial keratitis with significant growth of more than 1 organis

299 S, which induces transient herpes epithelial keratitis without herpes stromal keratitis sequelae, pos

300 mfort to the blinding disease herpes stromal keratitis, yet most patients experience a single episode