ライフサイエンスコーパス: keratopathy

1 logy in a case of Hurler syndrome-associated keratopathy.

2 lp to elucidate the pathogenesis of aniridic keratopathy.

3 d to understand the pathogenesis of diabetic keratopathy.

4 lar adhesion molecules is altered in bullous keratopathy.

5 dominant features of contemporaneous bullous keratopathy.

6 romising potential therapeutics for diabetic keratopathy.

7 may be a potential therapeutic for diabetic keratopathy.

8 care unit are at increased risk of exposure keratopathy.

9 so assessed within a rabbit model of bullous keratopathy.

10 nduced lipidosis and development of a vortex keratopathy.

11 gnificant role in the progression of bullous keratopathy.

12 eutic potential in the treatment of diabetic keratopathy.

13 DSAEK procedure due to pseudophakic bullous keratopathy.

14 ief to patients who develop it after bullous keratopathy.

15 tional complications, including neurotrophic keratopathy.

16 vestigated as a treatment option in diabetic keratopathy.

17 es as a unilateral subepithelial crystalline keratopathy.

18 othelial cell loss, and pseudophakic bullous keratopathy.

19 rney of pediatric patients with neurotrophic keratopathy.

20 Three children had neurotrophic keratopathy.

21 posing factors for an infectious crystalline keratopathy.

22 peripheral sensory neuropathy, and keratitis/keratopathy.

23 zation (CCUR) in diabetic rats with diabetic keratopathy.

24 duction of corneal and conjunctival punctate keratopathy.

25 itial misdiagnosis of infectious crystalline keratopathy.

26 apeutic option for the treatment of diabetic keratopathy.

27 red for decreased vision related to advanced keratopathy.

28 f corneal damage as assessed by the grade of keratopathy.

29 wing to nocturnal lagophthalmos and exposure keratopathy.

30 ease, exposure keratopathy, and neurotrophic keratopathy.

31 vision in eyes with SJS-induced lid-related keratopathy.

32 t survival in eyes with pseudophakic bullous keratopathy.

33 or Fuchs' dystrophy and pseudophakic bullous keratopathy.

34 ry corneal edema due to pseudophakic bullous keratopathy.

35 f corneal sensation, leading to neurotrophic keratopathy.

36 ongest in patients with pseudophakic bullous keratopathy.

37 chs endothelial dystrophy and 5 with bullous keratopathy.

38 ital thermal injuries and resultant exposure keratopathy.

39 ndothelial dystrophy or pseudophakic bullous keratopathy.

40 t of post-PRK dry eye and other neurotrophic keratopathies.

41 eal graft failure (2), phthisis (1) and band keratopathy (1).

42 endothelial dystrophy (260 eyes) or bullous keratopathy (15 eyes).

43 ases were performed for pseudophakic bullous keratopathy (2 cases, 1 in each cohort), and the remaini

44 MEK included 7 cases of pseudophakic bullous keratopathy, 2 cases of failed DMEK, and 1 case of faile

45 grade 3-4) were blurred vision (41% and 6%), keratopathy (29% and 9%), and nausea (29% and 0%).

46 neal dystrophy (32.5%), pseudophakic bullous keratopathy (35%), previous failed graft (27.5%), and ot

47 l outcomes of 23 DMEK procedures for bullous keratopathy (52%), failed previous transplant (39%), or

48 ition, which may lead to aniridia-associated keratopathy (AAK) and corneal blindness.

49 tween wild-type (WT) and aniridia-associated keratopathy (AAK) hiPSCs.

50 Keratopathy affected 65% of eyes and one-third underwent

51 Sixteen patients demonstrated dendritiform keratopathy after exposure to the preservative polyquate

52 Three patients developed severe toxic keratopathy after orofacial surgery on the left side wit

53 a surgery (aHR 1.86, 95% CI 1.10-3.14), band keratopathy (aHR 2.23, 95% CI 1.47-3.37), posterior syne

54 surgery (aHR, 11.9; 95% CI, 5.30-26.8), band keratopathy (aHR, 5.12; 95% CI, 2.34-11.2), and hypotony

55 eal densitometry in patients with amiodarone keratopathy (AK).

56 operative ocular complications included band keratopathy and a lack of methotrexate or adalimumab use

57 receptor alpha (PPARalpha) against diabetic keratopathy and corneal neuropathy.

58 and/or tear film may contribute to diabetic keratopathy and delayed epithelial wound healing in diab

59 by tear lipocalin from corneas with bullous keratopathy and dry eye.

60 One patient showed mild keratopathy and elevation of intraocular pressure with t

61 Crystalline keratopathy and Fanconi syndrome were present in 22% and

62 on eight cases each of pseudophakic bullous keratopathy and healthy corneas.

63 t with silicone oil tamponade developed band keratopathy and phthisis bulbi.

64 cornea in a patient presenting with bullous keratopathy and stinging symptoms.

65 halmic socket syndrome, and one had exposure keratopathy and traumatic dilated pupil.

66 ment challenges and may lead to neurotrophic keratopathy and vision loss.

67 us hemorrhage, epiretinal membrane, and band keratopathy), and visual outcomes-were collected from pa

68 rneal findings, such as superficial punctate keratopathy, and abnormal results of dry eye tests, such

69 ective in symptomatic improvement of bullous keratopathy, and infectious keratitis but further studie

70 om human corneas with chronic edema, bullous keratopathy, and keratoconus and from normal corneas wer

71 tion, postherpetic keratitis scarring, lipid keratopathy, and limbal stem cell deficiency.

72 ferentiated ocular surface disease, exposure keratopathy, and neurotrophic keratopathy.

73 conjunctival hyperemia, superficial punctate keratopathy, and prominent anterior chamber inflammation

74 unctal plugs were more effective in limiting keratopathy, and their use, particularly of bandage cont

75 ma (AOR = 3.11, 95%CI:1.06,9.17) and striate keratopathy(AOR = 3.4, 95%CI: 1.11, 10.88).

76 ca, and South America), pseudophakic bullous keratopathy/aphakic bullous keratopathy (North America),

77 deficiency being the primary cause of APS-1 keratopathy are not applicable to our unusual case of th

78 surgery, and prior graft failure or bullous keratopathy as surgical indication.

79 t common indication for PTK is still bullous keratopathy, as PTK can be successfully used while waiti

80 corneal healing than vehicle in neurotrophic keratopathy associated with nonhealing corneal defects.

81 thelium differentially and may contribute to keratopathy associated with severe ocular allergy.

82 ndothelial dystrophy or pseudophakic bullous keratopathy at a single tertiary center.

83 surgical indication was pseudophakic bullous keratopathy at a single tertiary center.

84 ting VA, glaucoma diagnosis, and cataract or keratopathy at presentation.

85 h SJS who presented with chronic lid-related keratopathy between 1990 and 2015.

86 of all patients diagnosed with dendritiform keratopathy between 1999 and 2014 who had documented exp

87 Fuchs endothelial dystrophy (FED) or bullous keratopathy (BK) in Asian eyes.

88 hy (FECD) subgroup, and 27.4% of the bullous keratopathy (BK) subgroup did not show visual improvemen

89 l corneal dystrophy (FECD; 85.3%) or bullous keratopathy (BK; 10.5%).

90 l corneal dystrophy (FECD; n = 314), bullous keratopathy (BK; n = 31), and failed previous endothelia

91 l corneal dystrophy [FECD]: n = 111; bullous keratopathy [BK]: n = 24; and failed graft: n = 18).

92 In early-stage aniridic keratopathy, BSCVA and tear BUT were reduced relative to

93 vels of ephrin-A1 may contribute to diabetic keratopathies by persistently engaging EphA2 and prohibi

94 th application of simple protocols, exposure keratopathy can be prevented, thus improving patient car

95 Tube shunt surgery, hypotony, band keratopathy, cataract surgery, and anterior segment infl

96 hesis that epithelial alterations in bullous keratopathy compromise the surface of the cornea and its

97 rneal scarring, neurotrophic keratitis, band keratopathy, corneal melt, elevated intraocular pressure

98 age was not detected in pseudophakic bullous keratopathy corneas, whereas it colocalized with termina

99 Diabetic keratopathy decreases corneal sensation and tear secreti

100 a 69-year-old woman with an asymptomatic keratopathy detected during a cataract intervention.

101 cluded ocular hypertension (67.4% vs 66.7%), keratopathy due to silicone oil emulsification and migra

102 dothelial dystrophy and pseudophakic bullous keratopathy, EK achieved better average best-corrected a

103 cluded corneal melts resulting from exposure keratopathy, endophthalmitis, and infectious keratitis o

104 In our study of eyes with bullous keratopathy, endothelial keratoplasty under a previously

105 ace disease and failing to identify exposure keratopathy, especially as a consequence of nocturnal la

106 In contrast, none of the bullous keratopathy eyes showed any improvement throughout the f

107 ndothelial dystrophy or pseudophakic bullous keratopathy from January 2006 through December 2011.

108 p 2 (n = 2), patients with progressive lipid keratopathy; group 3 (n = 4), post keratoplasty patients

109 Band keratopathy, >/= 3+ vitreous cells, exudative retinal de

110 Patients in group 2 with lipid keratopathy had 100% obliteration of vessels with stabil

111 graft (HR 2.07, 95% CI 1.84-2.32) or bullous keratopathy (HR 1.47, 95% CI 1.33-1.61) vs Fuchs dystrop

112 ith normal controls and pseudophakic bullous keratopathy (iatrogenic CE cell loss) specimens.

113 Neurotrophic keratopathy improved in 2 children without corneal neuro

114 demonstrated the coexistence of neurotropic keratopathy in LSCD.

115 dothelial dystrophy and pseudophakic bullous keratopathy in patients without other vision-limiting oc

116 thylamiodarone correlates with the extent of keratopathy in the anterior layer, whereas chronic chang

117 The grade of keratopathy in the ocular lubricant group increased sign

118 ery in the treatment of pseudophakic bullous keratopathy in the presence of sf-IOL and if-IOL can suc

119 the first report of pressure-induced stromal keratopathy in this context.

120 adverse events in the safety population were keratopathy (in 26 [27%] of 95 patients in the 2.5 mg/kg

121 fern-shaped branches, resembling crystalline keratopathy, in her left eye.

122 Pathogenesis of diabetic keratopathy involves multiple tissues and/or cell types

123 d with Fuchs' endothelial dystrophy, bullous keratopathy, iridocorneal endothelial syndrome or a fail

124 Paraproteinemic keratopathy is a rare disorder characterized by the bila

125 Hurler syndrome-associated keratopathy is an exceedingly rare corneal disorder that

126 In conclusion, keratopathy is an important complication of type 2 diabe

127 Early-stage aniridic keratopathy is characterized by the development of focal

128 early postoperative period when the risk of keratopathy is highest.

129 associated with nonocular surgery, but toxic keratopathy is rare.

130 The clinical presentation of exposure keratopathy is reviewed with tips for recognition for th

131 defects in this series included neurotrophic keratopathy, lattice and Avellino dystrophy, Stevens-Joh

132 Pseudophakic bullous keratopathy manifests an abnormal corneal ocular surface

133 ilateral axial proptosis, chemosis, exposure keratopathy, markedly distended eyelids and often, loss

134 Paraproteinemic keratopathy may present in its early stages as a unilate

135 n line, Acanthamoeba keratitis, mucus plaque keratopathy, medication-related keratopathy, or limbal s

136 elial corneal dystrophy (n = 28) and bullous keratopathy (n = 11).

137 Most common etiologies were neurotrophic keratopathy (n = 15), dysfunctional tear syndrome (n = 9

138 (n = 4), fungal keratitis (n = 2), exposure keratopathy (n = 2), failed graft (n = 1), peripheral ul

139 ft failure (n = 3), and pseudophakic bullous keratopathy (n = 2).

140 = 127; 90%) followed by pseudophakic bullous keratopathy (n = 4; 4%) and regrafts (n = 9; 6.4%).

141 chs endothelial dystrophy (n = 209), bullous keratopathy (n = 88), and previous graft failure (n = 39

142 tic globe rupture (six eyes, 27.3%), bullous keratopathy (nine eyes, 40.1%), failed previous graft (f

143 Neurotrophic keratopathy (NK) is a corneal degeneration associated wi

144 Neurotrophic keratopathy (NK) is a rare disease characterized by the

145 Neurotrophic keratopathy (NK) is a relatively uncommon, underdiagnose

146 pical insulin (TI) for treating neurotrophic keratopathy (NK) within one-month post-diabetic vitrecto

147 SS) aqueous tear deficiency, or neurotrophic keratopathy (NK), and 17 asymptomatic control subjects w

148 dophakic bullous keratopathy/aphakic bullous keratopathy (North America), and keratitis (Asia).

149 Exposure keratopathy occurred after severe periorbital thermal in

150 Diabetic keratopathy occurs in ~70% of all people with diabetes.

151 mucus plaque keratopathy, medication-related keratopathy, or limbal stem cell deficiency characterize

152 penetrating grafts for pseudophakic bullous keratopathy (P <0.001).

153 he differential diagnosis of any crystalline keratopathy, particularly when there are no predisposing

154 o had Fuchs dystrophy or pseudophakic bullus keratopathy (PBK) and underwent DSAEK or combined DSAEK

155 ndothelial dystrophy or pseudophakic bullous keratopathy (PBK) at a single institution.

156 FED and pseudophakic bullous keratopathy (PBK) corneal buttons were removed during tr

157 mal autopsy corneas and pseudophakic bullous keratopathy (PBK) corneas.

158 strophy and 9 eyes with pseudophakic bullous keratopathy (PBK) that underwent DSAEK, and 17 eyes with

159 for DMEK was pseudophakic or aphakic bullous keratopathy (PBK), followed by graft failure and Fuchs'

160 helial dystrophy (FED), pseudophakic bullous keratopathy (PBK), infection and other indications.

161 helial dystrophy (FED), pseudophakic bullous keratopathy (PBK), or keratoconus who had undergone a pe

162 For optical grafts, pseudophakic bullous keratopathy, postinfectious corneal scarring and thinnin

163 Paraproteinemic keratopathy (PPK) is a rare ocular manifestation of mono

164 nt, using bandage contact lenses for bullous keratopathy, presented with redness, mild pain and a sti

165 cemet membrane disorder), but not in bullous keratopathy (primarily an endothelial depletion).

166 ongest in patients with pseudophakic bullous keratopathy (r = -0.62 [P = .01]).

167 n of the corneal surface in aniridia-related keratopathy relates to both a deficiency within the limb

168 ed to advancing age and caused a progressive keratopathy, resulting in a dense vascularized corneal p

169 ed by 88 (21%) and mild superficial punctate keratopathy seen in 7 (1.7%).

170 In that respect, we can suggest that keratopathy should be evaluated more cautiously in diabe

171 uperficial cell layers were lower in bullous keratopathy specimens (1.6 vs. 2.0; P < 0.0001) than in

172 ent in sections was increased in the bullous keratopathy specimens compared with controls (0.36 vs. 0

173 ith antibodies to MUC16 was lower in bullous keratopathy specimens than in controls (0.5 vs. 1.2; P <

174 mer test I, presence of superficial punctate keratopathy (SPK), LG volume, and molecular analysis of

175 coexisting potential causes for dendritiform keratopathy, such as prior herpes simplex keratitis, var

176 from the literature regarding central toxic keratopathy syndrome (CTK).

177 ith ocular signs including high myopia, band keratopathy, t, nystagmus, retina, and optic nerve atrop

178 ning polyquaternium-1 may cause dendritiform keratopathy that may be confused with infections of the

179 e typical clinical appearance of crystalline keratopathy, the atypical evolution and test results led

180 In eyes with pseudophakic bullous keratopathy, the EndoGlide group had a superior graft su

181 antiseptic solutions may cause severe toxic keratopathy; this possibility should be considered in or

182 tients, including keratic precipitates, band keratopathy, trace to 2+ anterior chamber cells, cystoid

183 dothelial dystrophy and pseudophakic bullous keratopathy undergoing DSAEK surgery were included and r

184 ed in a pre-clinical rabbit model of bullous keratopathy using a tissue-engineered endothelial kerato

185 ated with them, such as pseudophakic bullous keratopathy, uveitis-glaucoma-hyphema syndrome, and chro

186 Neurotrophic keratopathy was associated most commonly with herpetic k

187 EK failure in pseudophakic bullous keratopathy was associated with center experience of few

188 duction of layers expressing MUC1 in bullous keratopathy was not statistically significant.

189 hthalmic examination, significant healing of keratopathy was noted in the lens group (p = 0.02 and 0.

190 Persistent keratopathy was observed in 3 eyes (4.5%).

191 for Fuchs' dystrophy or pseudophakic bullous keratopathy was poorer than survival of penetrating graf

192 To understand the cause of diabetic keratopathy, we investigated innervation and its correla

193 Keratopathies were the most common type of complication

194 Potential predictors of keratopathy were also explored.

195 Cataract, glaucoma, and keratopathy were associated with worse VA and are import

196 ng features in mucopolysaccharidosis-related keratopathy were concordant with histology.

197 ndothelial dystrophy or pseudophakic bullous keratopathy were randomized to DMEK or UT-DSAEK 1 to 2 d

198 ing glaucoma, pseudoexfoliation, and striate keratopathy were significantly associated with poor visu

199 ocular surface protection, or resolution of keratopathy) were achieved in all but 2 of these subject

200 complications (posterior synechiae and band keratopathy) were more common in the younger group (p =

201 present an atypical case of paraproteinemic keratopathy which lead to an initial misdiagnosis of inf

202 study included 23 patients with neurotrophic keratopathy who underwent indirect corneal neurotization

203 ndothelial dystrophy or pseudophakic bullous keratopathy who were considered good candidates for DMEK

204 ndothelial dystrophy or pseudophakic bullous keratopathy who were good candidates for DMEK or ultrath

205 ngle, together with pressure-induced stromal keratopathy with a fluid interface between the corneal s

206 ndothelial dystrophy or pseudophakic bullous keratopathy with or without cataract.

207 nd Afghanistan and were treated for exposure keratopathy with the BOSP, a Food and Drug Administratio

208 in the lubrication group developed exposure keratopathy, with a summary odds ratio of 0.208 (95% con