ライフサイエンスコーパス: ketogenic diet

1 esponds to dietary manipulation such as the 'ketogenic diet'.

2 onent of the medium-chain triglyceride (MCT) ketogenic diet.

3 tely reversed in GF mice by consumption of a ketogenic diet.

4 after C75 injection in rats maintained on a ketogenic diet.

5 nd glycolysis), valproic acid (VPA), and the ketogenic diet.

6 cover possible therapeutic mechanisms of the ketogenic diet.

7 est in alternative therapies, especially the ketogenic diet.

8 with standard diet (P < 0.001), but not with ketogenic diet.

9 exogenous ketone ester supplementation or a ketogenic diet.

10 g translatable approaches such as fasting or ketogenic diet.

11 e reduction and may be a sounder option than ketogenic diet.

12 icarboxylic acid cycle and glutamate under a ketogenic diet.

13 irs ketogenesis in response to fasting and a ketogenic diet.

14 ity and attenuated seizures in animals fed a ketogenic diet.

15 rmacologic inhibition of PI3K and SGLT2 or a ketogenic diet.

16 ney phenotype in cystinotic animals fed with ketogenic diet.

17 mechanism for the antiseizure action of the ketogenic diet.

18 mice consuming a high-fat, low-carbohydrate ketogenic diet.

19 ic action of a high fat and low carbohydrate ketogenic diet.

20 sant effect of the medium chain triglyceride ketogenic diet.

21 en fasted or fed a high-fat low-carbohydrate ketogenic diet.

22 nt antitumor mechanisms were launched by the ketogenic diet.

23 PHOS deficiency can be bypassed by feeding a ketogenic diet.

24 -intensity exercise, or the low-carbohydrate ketogenic diet.

25 to respond appropriately to consumption of a ketogenic diet.

26 to be exacerbated by fasting and high-fat or ketogenic diets.

27 LUT1-DS) who objected to or did not tolerate ketogenic diets.

28 olic and physiologic alterations provoked by ketogenic diets.

29 were 3-5 times those reported with high-fat ketogenic diets.

30 as the modified Atkins diet) other than the ketogenic diet, (2) the relatively frequent occurrence (

31 CS diagnosis rates for 72-h ketogenic diet, 24-h ketogenic diet and 18-h fasting pre

32 Myocardial suppression rates for 72-h ketogenic diet, 24-h ketogenic diet and 18-h fasting pre

33 et, glucose predominates throughout but in a ketogenic diet, 3-hydroxybutyrate contributes most stron

34 The ketogenic diet, a high-fat, low-carbohydrate regimen, is

35 nged deprivation of food or consumption of a ketogenic diet activates the IRE1alpha-XBP1 pathway in m

36 s, specifically Vegan, Typical American, and Ketogenic diets, all very common in the US context.

37 The ketogenic diet also may facilitate mechanisms by which t

38 d mortality, whereas carbohydrate-restricted ketogenic diets ameliorate T2D and suppress breast cance

39 Optimized cyclic ketogenic diet and 1,3-butanediol supplementation regime

40 iagnosis rates for 72-h ketogenic diet, 24-h ketogenic diet and 18-h fasting preparations are as foll

41 pression rates for 72-h ketogenic diet, 24-h ketogenic diet and 18-h fasting preparations are as foll

42 ldren were available for analysis: 54 on the ketogenic diet and 49 controls.

43 78 infants were assigned to a ketogenic diet and 58 to antiseizure medication, of whom

44 73 children were assigned to the ketogenic diet and 72 children to the control group.

45 ystem during protein absorption, following a ketogenic diet and an increased intake of antioxidants,

46 ch for a 4-wk period-an LC (4% carbohydrate) ketogenic diet and an MC (35% carbohydrate) diet-randomi

47 al decreases in total microbial loads on the ketogenic diet and enable us to determine the differenti

48 Dietary therapies, including the ketogenic diet and its variations, have been available f

49 lating FGF21 in response to starvation and a ketogenic diet and that FGF21 is required for behavioral

50 he epigenome gives us an appreciation of the ketogenic diet and the potential for bioenergetic therap

51 expression were observed in mice that ate a ketogenic diet and when fasting, which suggests that FGF

52 As both ketogenic diets and intermittent fasting increase circul

53 gamma coactivator-1alpha pathway activation, ketogenic diets and other new strategies is required.

54 Despite some benefit from ketogenic diets and vagal nerve stimulation, there has b

55 of GLUT1 deficiency has important treatment (ketogenic diet) and genetic counseling implications.

56 terventions such as caloric restriction, the ketogenic diet, and a high-fat diet systemically alter a

57 tabolic factors such as caloric restriction, ketogenic diet, and hyperglycemia influence the inflamma

58 study reveals that different formulations of ketogenic diets, and dietary fiber content in particular

59 tors, denosumab discontinuation, SARS-CoV-2, ketogenic diets, and extreme exercise, but these account

60 sacrifice, kidneys of knockout mice fed with ketogenic diet appeared macroscopically similar to those

61 In addition, the ketogenic diet appears to favor the synthesis of glutami

62 Ketogenic diets are also now being increasingly studied

63 Over 70% of obese humans have NAFLD and ketogenic diets are common weight loss strategies.

64 These properties of ketogenic diets are recapitulated by the ketone body bet

65 ite, a response that seems to be absent when ketogenic diets are used.

66 Ketogenic diets are very efficient to control epilepsy a

67 Ketogenic diets are very low carbohydrate, high fat, mod

68 usions, general anesthesia, hypothermia, and ketogenic diet as treatment for uncontrolled status epil

69 aimed to establish the efficacy of a classic ketogenic diet at reducing seizure frequency compared wi

70 In vivo, BHB or a ketogenic diet attenuates caspase-1 activation and IL-1b

71 A commonly used rodent ketogenic diet (Bio-Serv F3666) that is very high in fat

72 , not only as the mechanism of action of the ketogenic diet, but also as a potential target of future

73 me modulates the anti-seizure effects of the ketogenic diet, but how specific dietary formulations di

74 Ketogenic diet can change the metabolism in the body and

75 activation of RIPK1 or metabolic rescue with ketogenic diet can prevent postnatal lethality and BBB d

76 how the well-recognized clinical effects of ketogenic diets can alter human behavior via the same ce

77 Ketogenic diets can improve seizures in children older t

78 dy produced during fasting or adherence to a ketogenic diet, can inhibit the NLRP3 inflammasome and r

79 ose and -insulin conditions, associated with ketogenic diets, can reduce the activity of the mechanis

80 profiling demonstrates that maintenance on a ketogenic diet causes a 25% reduction of myocardial (13)

81 ulation of most microbial pathways following ketogenic diet compared with baseline and vegan diet.

82 under standard diet, overnight fasting, and ketogenic diet conditions.

83 A ketogenic diet consisting of a high ratio of fat to carb

84 hepatocytes following exercise, fasting, or ketogenic diet consumption.

85 A ketogenic diet could be a treatment option in infants wh

86 e, we have explored whether treatment with a ketogenic diet could lead to a similar rescue through in

87 fied into 6 overarching thematic groups: (1) ketogenic diets, diabetes, supplements, and statins; (2)

88 Ketogenic diet, diazepam, valproate, potassium bromide a

89 In this phase 4 trial, a ketogenic diet did not differ in efficacy and tolerabili

90 Children were randomly assigned to receive a ketogenic diet, either immediately or after a 3-month de

91 Notably, although a high-fat ketogenic diet elevates ISC function and post-injury reg

92 ermia, magnesium, pyridoxine, immunotherapy, ketogenic diet, emergency neurosurgery, electroconvulsiv

93 Through these mechanisms, AMPK agonists or ketogenic diets enhance the efficacy of anti-CTLA-4 immu

94 he mechanisms through which low carbohydrate ketogenic diets exert their ameliorative effects still r

95 chthonous animal models of CRC and find that ketogenic diets exhibit a strong tumour-inhibitory effec

96 Weaning mice to a ketogenic diet extends viability to 8.5 wk.

97 ncentrations are higher within the hearts of ketogenic diet-fed mice challenged with ketones compared

98 mpared with chow-fed C57BL/6 mice, fasted or ketogenic diet-fed mice displayed increased hepatic TG c

99 dies required for survival during fasting or ketogenic diet feeding.

100 igh lipid utilization, including fasting and ketogenic diet feeding.

101 s induced by an overnight fast or short term ketogenic diet feeding.

102 However, we found that Pcx(L-/-) mice fed a ketogenic diet for 1 week became severely hypoglycemic,

103 esions in Eker rats (Tsc2+/-) subjected to a ketogenic diet for 4, 6 and 8 months.

104 by parents of some children treated with the ketogenic diet for epilepsy control, although this side

105 participants sequentially consumed vegan or ketogenic diets for 2 weeks ( NCT03878108 ).

106 The use of ketogenic diets for weight loss is not warranted.

107 s were replicated in Ctns(-/-) rats fed with ketogenic diet from 2 to 8 months of life.

108 When Ctns(-/-) mice were fed with ketogenic diet from 3 to 12 months of age, we observed s

109 the age of 3 years who were treated with the ketogenic diet from April 2004 to June 2014 were retrosp

110 also observed after mice were fed with this ketogenic diet from the age of 6 months to the age of 15

111 nd randomised group, was similar between the ketogenic diet group (5 [IQR 1-16]) and antiseizure medi

112 h groups (40 [51%] of 78 participants in the ketogenic diet group and 26 [45%] of 58 participants in

113 The ketogenic diet had no effect in these models.

114 Ketogenic diet had significant benefits for preventing k

115 A ketogenic diet has also been found to induce mitochondri

116 The ketogenic diet has been widely and successfully used to

117 creased availability of anticonvulsants, the ketogenic diet has re-emerged as a therapeutic option.

118 therapy for pediatric epilepsy known as the ketogenic diet has seen a revival in its clinical use du

119 treatments such as the high-fat, antiseizure ketogenic diet have become mainstream, and metabolic sub

120 n of the diet (the medium-chain triglyceride ketogenic diet), have been shown to directly inhibit AMP

121 High-fat, low-carbohydrate diets, known as ketogenic diets, have been used as a non-pharmacological

122 ion, pyridoxine, steroids and immunotherapy, ketogenic diet, hypothermia, emergency resective neurosu

123 f this study was to test the efficacy of the ketogenic diet in a randomised controlled trial.

124 Here, we report that a ketogenic diet in Kmt2d(+/betaGeo) mice modulates H3ac a

125 onsible for the antiepileptic effects of the ketogenic diet in mice.

126 f this includes the therapeutic benefit of a ketogenic diet in neurologic diseases, including epileps

127 ning could in part explain the effect of the ketogenic diet in reducing epileptic seizures.

128 es that several mechanisms may exist for the ketogenic diet, including disruption of glutamatergic sy

129 Ketogenic conditions-starvation or ketogenic diet-increase K8(+/+) HMGCS2, whereas this res

130 Strikingly, a ketogenic diet increased lysine acetylation in Cpt2M(-/-

131 OR inhibition, serum-starvation/fasting, and ketogenic diet, increased ASO-mediated target reduction

132 The ketogenic diet induced hepatic lipid oxidation and ketog

133 Here we focus on a novel hypothesis that a ketogenic diet-induced change in energy metabolism incre

134 Here, we report that ketogenic-diet-induced changes in energy status enhance

135 tion of a high fat, low carbohydrate (HF-LC) ketogenic diet induces hepatic fibroblast growth factor

136 may contribute to the beneficial effects of ketogenic diet intervention in aged mice and in human su

137 pecific diets (i.e., complex carbohydrate or ketogenic diet), iron supplementation, and albumin infus

138 The ketogenic diet is a high-fat, adequate protein, low carb

139 A ketogenic diet is a potential adjuvant cancer therapy th

140 The medium chain triglyceride ketogenic diet is an established treatment for drug-resi

141 ingly, the use of therapeutic hypothermia or ketogenic diet is described as a strategy for super-refr

142 A ketogenic diet is used as anti-seizure therapy i.a. in t

143 er 80 years ago with the introduction of the ketogenic diet, is required.

144 Although caloric restriction (CR) and a ketogenic diet (KD) are often thought to limit tumour pr

145 on glucose has driven interest in using the ketogenic diet (KD) as a treatment for GBM.

146 A ketogenic diet (KD) can induce weight loss and improve g

147 The full anticonvulsant effect of the ketogenic diet (KD) can require weeks to develop in rats

148 ed clinical evidence to support the use of a ketogenic diet (KD) for cancer patients.

149 The high-fat ketogenic diet (KD) has become an increasingly popular d

150 A ketogenic diet (KD) has been reported to enhance respons

151 The ketogenic diet (KD) has emerged as a dietary regime that

152 Weight loss by ketogenic diet (KD) has gained popularity in management

153 The whole foods plant-based diet (WFPBD) and ketogenic diet (KD) have gained popularity in oncology,

154 virus infection, and whether a pro-longevity ketogenic diet (KD) impacts immune surveillance, we deve

155 Assess the tolerability of a ketogenic diet (KD) in patients with relapsing multiple

156 We asked whether a high-fat ketogenic diet (KD) increases UCP levels and activity in

157 The ketogenic diet (KD) is a high fat and low carbohydrate d

158 A ketogenic diet (KD) is a high-fat, low-carbohydrate diet

159 A ketogenic diet (KD) is a high-fat, low-carbohydrate meta

160 The ketogenic diet (KD) is a high-fat, low-carbohydrate, and

161 The ketogenic diet (KD) is a normocaloric diet composed of h

162 The ketogenic diet (KD) is an effective treatment option for

163 gated whether an isocaloric low-carbohydrate ketogenic diet (KD) is associated with changes in EE, re

164 The ketogenic diet (KD) is the standard of care to achieve m

165 severity and neurotoxicity in AUD and that a ketogenic diet (KD) may mitigate these effects.

166 An attenuating effect of the ketogenic diet (KD) on CRC cell growth has been previous

167 Previous studies have shown that animals fed ketogenic diet (KD) perform better in learning tasks tha

168 sarcoidosis, requiring preparation with the ketogenic diet (KD) to achieve myocardial glucose suppre

169 aOHB), the main ketone body (KB) produced in ketogenic diet (KD), is neuroprotective in aralar-knock-

170 s with AAAs received either a standard diet, ketogenic diet (KD), or exogenous KBs (EKB).

171 increases with fasting and consumption of a ketogenic diet (KD).

172 g or treatment with the high-fat antiseizure ketogenic diet (KD).

173 ydrate, 35% fat, 15% protein) and isocaloric ketogenic diets (KD; 5% carbohydrate, 80% fat, 15% prote

174 riched exclusively in saturated fatty acids (ketogenic diet; KD) confer a hyper-inflammatory response

175 Ketogenic diets (KDs) are popularly used to aid a myriad

176 Intermittent short-term fasting (ISTF) and ketogenic diets (KDs) exert overlapping but not identica

177 High-fat, low-carbohydrate ketogenic diets (KDs) have shown beneficial effects in m

178 Very low-carbohydrate, high-fat ketogenic diets (KDs) induce a pronounced shift in metab

179 Ketogenic diets (KDs)-very-low-carbohydrate and very-hig

180 Ketogenic diets (KGDs) have proven effective for disorde

181 Specifically, murine ketogenic diet lacks the complex spectrum of phytochemic

182 We examined the effect of a low carbohydrate ketogenic diet (LCKD) (80% kcal from fat, ketogenic rati

183 Second, common ketogenic diets lead to a therapeutically counterintuiti

184 Ketogenic diet may provide a partial therapeutic alterna

185 flammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition

186 Caloric restriction and ketogenic diets may modify the progression of neurologic

187 mary circulating ketone body produced by the ketogenic diet, may mediate its effects on seizures by b

188 d be suppressed by a carbohydrate-restricted ketogenic diet, MEDICA treatment suppressed tumor growth

189 ll now turn to dietary therapies such as the ketogenic diet, medium-chain triglyceride diet, modified

190 The mechanisms underlying the ketogenic diet might also have roles in other disorders,

191 asting or by maintaining a low-carbohydrate (ketogenic) diet might reduce epileptic seizures and offe

192 rials comparing different dietary therapies (ketogenic diet, modified Atkins diet, and low glycemic i

193 o mediate the stimulatory effect of an HF-LC ketogenic diet on FGF21 expression.

194 chemically and histologically the effects of ketogenic diet on kidney disease of two animal models of

195 information is available on the effect of a ketogenic diet on plasma lipoproteins in children with d

196 Beneficial effects of ketogenic diet on tubular function were also observed af

197 trial, all of whom were randomly assigned a ketogenic diet: one child (who also had dystonic cerebra

198 without stratification, to either a classic ketogenic diet or a further antiseizure medication for 8

199 entified NLRP3 inflammasome blockade using a ketogenic diet or betaHB supplementation as a potential

200 ctive of whether ketosis was achieved with a ketogenic diet or exogenous ketone ester.

201 demonstrate that energy stress induced by a ketogenic diet or fasting can enhance checkpoint blockad

202 Young adult rats and mice were placed on the ketogenic diet or maintained on control diet.

203 eckpoint blockade and advocate for combining ketogenic diets or AMPK agonists with anti-CTLA4 immunot

204 liver AQP9 levels were observed in rats fed ketogenic diets or high-protein diets, but AQP9 levels w

205 These data suggest that ketogenic diets or other ketogenic treatments might be u

206 nic diet: OR, 8.6 [95% CI, 3.7-20.0]), while ketogenic diet (OR, 6.5 [95% CI, 2.3-18.0]) and modified

207 inuation rates were significantly higher for ketogenic diet (OR, 8.6 [95% CI, 1.8-40.6]) and modified

208 ed Atkins diet: OR, 11.3 [95% CI, 5.1-25.1]; ketogenic diet: OR, 8.6 [95% CI, 3.7-20.0]), while ketog

209 Replacing chow by ketogenic diet overrode the macroH2A1.1-dependent metabo

210 es of hepatic oxidative fluxes fueled by the ketogenic diet paralleled lower rates of de novo lipogen

211 and had not been treated previously with the ketogenic diet participated in a randomised controlled t

212 ch as starvation, diabetic ketoacidosis, and ketogenic diets, play a potentially important role in re

213 ere, we show that a carbohydrate-restricted (ketogenic) diet potentiates CI induced by intermittent h

214 The ketogenic diet produced good seizure control.

215 A high-fat ketogenic diet produced significant increases in the ath

216 ate diets offered balanced benefits, whereas ketogenic diets produced greater weight loss but greater

217 bgroup of the 371 patients accepted into the ketogenic diet program between 1994 and 2001.

218 Ketogenic diets promote nutritional ketosis and have sho

219 Prolonged feeding of a ketogenic diet promotes the growth of renal tumors by re

220 These results suggest that the ketogenic diet provides a promising therapeutic strategy

221 e short term, high-protein, low-carbohydrate ketogenic diets reduce hunger and lower food intake sign

222 These data suggest that a ketogenic diet-related bleeding tendency occurs in about

223 Anticonvulsant mechanisms of the ketogenic diet remain incompletely understood.

224 Traditional antiseizure medications and the ketogenic diet remain the main treatment options.

225 A low-carbohydrate ketogenic diet remains one of the most effective (but my

226 All three patients who tried the ketogenic diet responded well to this treatment, and fut

227 Growing evidence suggests that one of the ketogenic diet's main mechanisms of action is reducing i

228 is preclinical study, we demonstrated that a ketogenic diet significantly improves colitis in CGD mic

229 At 6 months, the high-fat ketogenic diet significantly increased the mean plasma l

230 Additional animals received the ketogenic diet (starting at 20 or 60 d old).

231 consideration of dietary choline content in ketogenic diet studies in rodents to limit hepatic mitoc

232 Analysing medium-chain fatty acids in future ketogenic diet studies will provide further insights int

233 In a murine ketogenic-diet study, we compare microbial loads in lume

234 The results from this trial of the ketogenic diet support its use in children with treatmen

235 as the perceived absolute requirement for a ketogenic diet, the assumed lack of structural brain def

236 termittent fasting, fasting-mimicking diets, ketogenic diets, time-restricted feeding, protein restri

237 R in mice suppressed the ability of an HF-LC ketogenic diet to induce hepatic FGF21 gene expression.

238 Depletion of glucose levels using a ketogenic diet to lower lactate production by glycolytic

239 mised cells points to the potential use of a ketogenic diet to treat patients with heteroplasmic mtDN

240 (24 h of fasting and a very low carbohydrate ketogenic diet) to demonstrate that heart muscle engages

241 However, the effectiveness of ketogenic diets toward alleviating NAFLD remains unclear

242 Behavioral assays indicate that ketogenic diet treatment leads to the prolonged rescue o

243 Ketogenic diet treatment of Shank3-deficient mice elevat

244 Ketogenic diet treatment significantly reduced tactile a

245 ave been shown in the rat hippocampus during ketogenic diet treatment.

246 Our findings reveal that on a ketogenic diet, treatment with eFT508 (also known as tom

247 y pharmacological stimulation of PDH or by a ketogenic diet, two treatments used for PDH deficiencies

248 Our data revealed that overall, a ketogenic diet was associated with a significant upregul

249 A 4:1 ketogenic diet was maintained for 15 mo, and whole-body

250 mpared to other treatment options, while the ketogenic diet was most effective in maintaining seizure

251 Only a decade ago the ketogenic diet was seen as a last resort; however, it ha

252 bohydrates are restricted in patients on the ketogenic diet, we evaluated the effects of limiting car

253 g opinions about the anticancer actions of a ketogenic diet, we have shown that this anti-seizure the

254 iciency on the pleiotropic effects of rodent ketogenic diets, we studied four custom diets that diffe

255 e first year of life, while clobazam and the ketogenic diet were effective in long-term seizure manag

256 er barbiturates, vagus nerve stimulator, and ketogenic diet were not associated with outcome.

257 In 2009, two controlled trials of the ketogenic diet were published, as well as an Internation

258 and adults with G1D who were not receiving a ketogenic diet were selected on a first-come, first-enro

259 iabetes or T2DM followed the well-formulated ketogenic diet (WFKD) and the Mediterranean-plus diet (M

260 endurance sports and as medical treatment in ketogenic diets where these diets regulate energy metabo

261 eek-old) Shank3-deficient mice with a 4-week ketogenic diet, which can act as an endogenous inhibitor

262 eek-old) Shank3-deficient mice with a 4-week ketogenic diet, which can act as an endogenous inhibitor

263 duals with epilepsy benefit from consuming a ketogenic diet, which is similar to the more commonly kn

264 at liver were dramatically up-regulated by a ketogenic diet, which lowered HNE basal level.

265 tant adjunct to pharmacologic therapy is the ketogenic diet, which often improves seizure control, ev

266 (n = 94); 18h-fasting (n = 44); 72-h daytime ketogenic diet with 3-day overnight fasting (n = 98).

267 e report (k=0.88) Conclusion: A 72-h daytime ketogenic diet with 3-day overnight fasting, achieved su

268 ts were applied from 03/2014 to 12/2019.24-h ketogenic diet with overnight fasting (n = 94); 18h-fast

269 superior myocardial suppression versus 24-h ketogenic diet with overnight fasting and 18h-fasting us

270 I3K inhibitors is dramatically enhanced by a ketogenic diet, with a proposed mechanism involving diet

271 compared with littermate control mice fed a ketogenic diet, yet it did not improve cardiac hypertrop