ライフサイエンスコーパス: key

1 ple in-depth structural analyses to identify key ACE2 amino acid positions including 30, 83, 90, 322,

2 We discover three causal SNPs of EPAS1, the key adaptive gene for Tibetans.

3 of social-network plasticity and feedback as key adaptive mechanisms for refining individual and coll

4 This review highlights key advances in scalable biocatalytic C-H oxyfunctionali

5 We highlight key advantages and limitations of the tool and compare i

6 ncapsulation approach, could therefore offer key advantages for clinical translation.

7 ch branches in the tree are likely to harbor key affinity-increasing mutations?

8 ere mapped from phosphoproteomics data among key and emerging GPVI effectors (ie, FcRgamma, Syk, PLCg

9 Class A serine beta-lactamases (SBLs) are key antibiotic resistance determinants in Gram-negative

10 of simulation for drug discovery, we review key applications of advanced methods for sampling comple

11 lend film in organic solar cells (OSCs) is a key approach to improve device efficiencies.

12 nucleotide-based drug platforms, focusing on key approaches - including chemical modification, biocon

13 Key architectures obtained through NCA ROP or in combina

14 is" and flavin-mediated taxis, and highlight key areas in need of further investigation.

15 Here, I provide my perspective on four key areas that need further research to inform curative

16 erular filtration rate (GFR) assessment is a key aspect in the evaluation of living kidney donor cand

17 Pattern formation is a key aspect of development.

18 relationships is poor, despite this being a key aspect of the nursing role and a major contributor t

19 findings can help investigators to focus on key aspects most in need of attention when reporting PRO

20 This study describes key aspects of the interaction between primary human neu

21 To better target these viruses, we examined key aspects of the viral life cycle in three-dimensional

22 g factors in cerebrospinal fluid (CSF) and a key barrier between blood and brain.

23 griculture and Food (TEEBAgriFood) to assess key benefits and costs on the production side of genetic

24 Its key benefits are that extraction of mycotoxins can be ca

25 the importance of mitonuclear coevolution in key biological processes such as speciation and mitochon

26 ss as histologically observed, and modulated key bone remodeling and inflammatory mediators in rats w

27 via small adjustments of neural circuitry in key brain areas.

28 Halopyridines are key building blocks for synthesizing pharmaceuticals, ag

29 The differential effects of YAP and TAZ on key cellular processes were also associated with differe

30 The key challenge in generating antibody-based inhibitors is

31 Here, we define ten key challenges facing cancer immunotherapy, which range

32 Strategies are presented that address key challenges for the preparation of coordination cages

33 A key characteristic of 2 and 3 is that they possess a LUM

34 um regulators indicated ERF-1 as a potential key checkpoint of cambial activities, explaining how cam

35 Lissencephaly-1 (Lis1) is a key cofactor for dynein-mediated intracellular transport

36 opium chelate-conjugated probe, which is the key component in sensing the hydrophobic regions exposed

37 acoronaviruses in lineages A and C, and be a key component in the evolution of SARS-CoV-2 with this s

38 factors for the induction of interferons, a key component in vertebrate innate immunity.

39 Background Hyperemia is a key component of acute myocarditis (AM).

40 Handwashing is a key component of guidance to reduce transmission of the

41 ram evaluation and outcome measurement are a key component of implementation.

42 In summary, mtACP, as a key component of mitochondrial fatty acid biosynthesis,

43 ports current recommendations that VMMC is a key component of programs to reduce HIV incidence.

44 s a robust downregulation of neuroligin-2, a key component of the inhibitory synapse, in the NAc that

45 IFN-beta is a key component of the innate immune response to viral inf

46 e-associated membrane protein 4 (VAMP4) as a key component of the machinery that maintains these Ca(2

47 naling is also a target for decanoic acid, a key component of the medium-chain triglyceride (MCT) ket

48 or pharmacological inhibition of IFN-beta, a key component of type I IFN mechanisms to address its ro

49 or environmental aspects and have emerged as key components in determining cancer cell metabolism.

50 Together, our findings define key components in HBV cccDNA formation.

51 To explore the molecular characteristics and key components of the aortic microenvironment, where the

52 rved a reduction in a subset of 8, including key components of the nuclear pore complex scaffold and

53 Key components of the photosynthesis gene regulatory net

54 Surface defects have been a key constraint for perovskite photovoltaics.

55 role of neuroimmune cross-talk surfaced as a key contributor to cancer progression.

56 nd Cl(-) ions, demonstrate the importance of key coordinating residues for transporter activity, and

57 The key correlates of this contraction are large body mass,

58 unction assessed at Y30 after adjustment for key covariates.

59 Identify key demographic factors and modes of follow-up in surgic

60 ning associations with immune parameters and key demographics.

61 tion of beta-cell L-type Ca(V) channels is a key determinant of beta-cell glucose-stimulated Ca(2+) e

62 lum Ca(2+) ATPase (SERCA) pump is one of the key determinants of the phenotypes seen in various muscl

63 epth through stoichiometric reactions of the key diazatitanacyclohexadiene intermediate, which can be

64 Key differences from applications in crystallography are

65 Current models only partially recapitulate key disease features, and pathophysiology is poorly unde

66 iated with venom production and to highlight key distinctions of venom gland cellular and physiologic

67 ial cell wall biosynthesis by disassembly of key divisome proteins, the cornerstone to bacterial cell

68 Key drivers of hyperinflammation induced by fungal cell

69 F-kappaB family of transcription factors are key drivers of inflammation that activate sets of genes

70 es, food security, and maternal nutrition as key drivers of stunting decline.

71 f image interpretation, quality assurance is key during image acquisition.

72 enascin-C (TNC) was identified as one of the key ECM markers in the lung epithelial-mesenchymal inter

73 Autonomous switches are key elements for improving the harvested energy per mech

74 with the broader natural sciences, but leave key elements of cognition and behaviour unexplained.

75 sistent secondary prevention can prove to be key elements to improving post-discharge morbidity and m

76 ant alterations in gene expression levels of key enzymatic regulators of biochemical reactions linked

77 Human tyrosinase (hsTYR) is the key enzyme ensuring the conversion of l-tyrosine to dopa

78 ice deficient for ELOVL2 (Elovl2(-/-) ), the key enzyme in DHA synthesis.

79 AN AMINOTRANSFERASE OF ARABIDOPSIS (TAA1), a key enzyme in the auxin biosynthesis pathway in Arabidop

80 areas, especially in the Miocene that was a key epoch shaping the worldwide distribution.

81 Tear film stability is the key event in ocular surface diseases.

82 ar, oxidative stress sensing appears to be a key factor involved.

83 Reduced food availability is the key factor limiting urban offspring growth and survival,

84 n spontaneous neurotransmitter release are a key factor to account for disease heterogeneity.

85 We postulate that a key factor underlying adaptation is the self-generated a

86 a particular chromatin architecture, is the key factor.

87 ation and secondary structure appeared to be key factors affecting both cheese microstructure and pro

88 ctivator 1alpha], PPARalpha, and catalase as key factors in antioxidant response, as well as the expr

89 This review introduces the key factors in enterohepatic recycling, especially the m

90 Key factors that gauge this compactness are the presence

91 are similar in most respects but differ in a key feature.

92 ection algorithm is effective in recognizing key features and control false discoveries for class-imb

93 Four key features of DVME that allow for the rapid collection

94 show that our assembly model reproduces many key features of ecological systems, such as the role of

95 We tested for three key features of HPA aging identified in many human studi

96 above a critical supersaturation reproduced key features of the experiments.

97 dy provides critical insight into drivers of key flowering phenophases and confirms that Hopkins' Bio

98 duced downregulation of GRK2 in the liver is key for allowing complete glucagon-mediated responses an

99 his differential vulnerability may provide a key for developing new treatments for PD.

100 onably large training datasets that hold the key for label-free single-cell analysis and, consequentl

101 ial organization of this species provide the key for such a solution.

102 , the supralaryngeal articulators, which are key for the production of speech sounds in humans.

103 n HIV-1-specific immune response seems to be key for the spontaneous functional cure.

104 construct is polyhedric, comprising several key forms: grandiose versus vulnerable, agentic versus c

105 essential for degradative autophagy, have a key function in maintaining immune quiescence of tissue-

106 d ATAD3C, the protein product of which lacks key functional residues.

107 on G protein-coupled receptors (aGPCRs) have key functions in diverse biological processes including

108 ation tolerance, implying that CsrA controls key functions involved in the transmission of A. baumann

109 ai transmission and exciton migration; these key fundamental pai functions are unique to sp(2) carbon

110 Promotion of C-C bonds is one of the key fundamental questions in the field of CO(2) electror

111 ally, TALP-3 and ANKR-26 form a complex with key gating component DYF-19, the homolog of FBF1.

112 quence detection were performed, focusing on key genes associated with PR (mgrB, crrAB, phoPQ, and pm

113 (trh), ventral veinless (vvl), and cut (ct), key genes involved in tracheal development, this study p

114 ed decrease in the expression of many of the key genes required for intracellular accommodation of ar

115 Identifying the functional variants and key genes within these association regions remains a maj

116 profound implications for the study of this key GTPase in cancer, particularly because a large numbe

117 g prolific innate killers, NK cells are also key helper cells in antiviral defense, influencing adapt

118 ssor of variegation 3-9 homolog 2 (SUV39H2), key histone-modifying enzymes involved in promoting redu

119 The precuneus (PreC; Brodmann area 7), a key hub within the default mode network (DMN) displays a

120 Three key hypotheses have been used to explain these macroecol

121 The key ideas of our method are the formation of compressed

122 Antibodies are key immune effectors that confer protection against path

123 These results highlight key immunological leukocyte subsets as well as associate

124 izing the role of temporal code in conveying key information about changes in nociceptive output in p

125 study suggests that dysfunctional pDCs are a key initial mechanism associated with poor HIV control.

126 Recent key innovations in flexible electrochemical bioelectroni

127 CAL1 binds CENP-A/H4 and CENP-C, we provide key insights into the minimalistic principles underlying

128 This finding provides key insights into the thermodynamic mechanism for the nu

129 ion networks within the heart, we identified key intercellular trophic relationships and shifts in ce

130 how that individual heterogeneity provides a key intermediary mechanism with broad consequences for s

131 his favors the protonation of *CO to *CHO, a key intermediate for methane generation, compared to the

132 Our synthesis uses key intermediates in the prebiotic synthesis of the cano

133 The key intermediates of this reaction are the corresponding

134 Key intermediates were isolated and comprehensively char

135 was characterized by formation of just a few key intermolecular contacts and was otherwise highly str

136 -Burman clades, and support the existence of key internal relationships.

137 adenoma (DRA) protein, encoded by SLC26A3, a key intestinal chloride anion exchanger, has recently be

138 Dragonflies are sentinel species that are key invertebrate predators in both aquatic (as larvae) a

139 In this Perspective we present key islet miRNA families involved in T2D pathogenesis in

140 sistance can act as an agent of selection on key life-history strategies and promote the evolution of

141 Variation of key ligand residues within the short sequence was undert

142 Key limitations include focusing just on the sickest sub

143 Key limitations include the descriptive nature of the an

144 at DNA methylation turnover might facilitate key lineage decisions.

145 Our findings define AP-1 as the key link between T cell activation and chromatin remodel

146 a metabolic shift from glucose to lipid is a key mechanism in neurodegeneration.

147 antibodies have been proposed as a potential key mechanism of protection against many viral pathogens

148 equent onset of fibril sliding is one of the key mechanisms leading to fracture.

149 Our work uncovers SETD5 as a key mediator of acquired MEKi therapy resistance in PDAC

150 I interferon, are principally recognized as key mediators of antiviral immunity.

151 We identify key methodological shortcomings of current epidemiologic

152 A key missing aspect is that real single cell data usually

153 ance of the spatial and temporal location of key molecular events, which may guide the evaluation of

154 n D supplementation attenuated expression of key molecules involved in adipose tissue browning and am

155 that m6A functions to enhance translation of key morphogenetic regulators, while also destabilizing s

156 osa (control-NM), in order to identify which key mRNA and microRNAs are regulating this complex proce

157 were correlated with restored expression of key MSN and neural activity marker genes in the NAc.

158 ults suggest that SWIM analysis can identify key network modules related to complex diseases like COP

159 Here we find that a key neuromodulator, ACh, can alter the balance of excita

160 iptional program modulates the expression of key neuronal remodeling genes, including S100a10 (p11),

161 The wavefront dynamics of key nonlinear processes including Kerr self-focusing, io

162 that HTLV-1-infected T-cell clones carrying key oncogenic driver mutations can be detected in cases

163 Quantum walk is a key operation in quantum computing, simulation, communic

164 athogens avoid activating NOS2 by concealing key PAMPs from their cognate TLRs.

165 he gas-liquid mass transfer coefficient is a key parameter to the design and operation of biotricklin

166 al idea of this joint effort is to highlight key parameters and pitfalls that are often encountered i

167 tion with the Ensembl project, which forms a key part of our future strategy for dealing with the inc

168 Water and lipids are key participants in many biological processes, but there

169 vascular coupling have been proposed to be a key pathogenic factor in the onset and progression of Al

170 the molecular mechanisms of these 2 emerging key pathways driving the pathogenesis of AF.

171 ive anaerobe, Porphyromonas gingivalis, is a key periodontal pathogen, and several lines of evidence

172 Moreover, key physical properties of complex-oxide thin films, suc

173 ation functionalities, thereby expanding the key physicochemical properties that are relevant for app

174 binding protein 43 (TDP-43) has emerged as a key player in many neurodegenerative pathologies, includ

175 Tau tubulin kinase 2 (TTBK2) is a key player in the cilium assembly pathway, controlling t

176 f murine breast cancer cells to identify the key players establishing epithelial-mesenchymal cell pla

177 trol of the food carbonylome seems to be the key point to control HAA formation in foods.

178 Key points and practice-based recommendations for the di

179 be attributable to decreased visitation from key pollinator species, such as bumble bees, at warmer s

180 Further research on key populations and their roles in HIV implementation an

181 Here we provide evidence supporting the key predictions that prestige-biased social learning is

182 In Taiwan, DM, eye trauma, and dry eye were key predisposing factors for microbial keratitis.

183 e of versatile earth-abundant materials is a key prerequisite.

184 ons express LepR, some of which project to a key presympathetic hub, the rostral ventrolateral medull

185 We propose a set of five key principles relevant to the European Medicines Agency

186 sion, is associated with profound changes in key processes of intercellular communication, involving

187 in the induction of IkappaBzeta, which is a key proinflammatory transcription factor required for cy

188 Key proportions of patients with findings of pulmonary i

189 ) activities that activates transcription of key protooncogenes, including MYC We report that BRD4 ph

190 New key questions focused on the yield of alternative HBV sc

191 The key reaction is a palladium-catalysed polyenyne cycloiso

192 ng or altering best practices, and establish key recommendations for the conduct and analysis of clin

193 Therefore, TrkB signaling is a key regulator of a previously uncharacterized neuronal p

194 s calcium-dependent protein kinase CPK3 is a key regulator of both pattern-triggered immunity and eff

195 endent protein kinase kinase-2 (CaMKK2) is a key regulator of cellular and whole-body energy metaboli

196 Levels of glutathione, a key regulator of cellular redox status, are reduced in t

197 in arginine methyltransferase 1 (PRMT1) is a key regulator of hepatic immune responses.

198 liferator-activated receptor (PPAR) delta as key regulator of osteoblast metabolism.

199 PI3Kdelta is a key regulator of regulatory T (Treg) cell function.

200 and cytidine residues, are now recognized as key regulators of both cellular and viral mRNA function.

201 Phosphoinositides (PI) are key regulators of cellular organization in eukaryotes an

202 Gap junctions and connexin hemichannels are key regulators of the biology of neural progenitors duri

203 YAP as a broad transcriptional repressor of key regulators of the cell cycle, in turn influencing co

204 n-neoplastic monocytic cells have emerged as key regulators of tumor maintenance and progression.

205 ations, assess network topology and identify key regulators.

206 trates with linear polyubiquitin chains is a key regulatory step in signal transduction that impacts

207 f even well-powered studies to resolve these key relationships.

208 Taken together, our findings reveal a key role and an epigenetic mechanism of action of NONO i

209 lies of enamel matrix proteins (EMPs) play a key role as the structural scaffolds for regulating mine

210 In combination, these findings establish a key role for microbiome-dependent circadian GLP-1 secret

211 se results suggest that gaze dynamics play a key role in action selection during challenging visuomot

212 Cytotoxic T cells play a key role in adaptive immunity by killing infected or can

213 of chromatin inside the cell nucleus plays a key role in gene regulation and genome replication, as w

214 r results indicate that the apicoplast has a key role in heme biology in T. gondii and is important f

215 ely transient neurons of the subplate play a key role in integrating spontaneous and sensory-driven a

216 cade of the innate immune system and plays a key role in microbial defense, inflammation, organ devel

217 ds like RNA and other polynucleotides play a key role in modulating protein phase separation.

218 gens need to be investigated, as they play a key role in synaptogenesis and corticogenesis during pre

219 oupled receptor (GPCR) kinases (GRKs) play a key role in terminating signals initiated by agonist-bou

220 repertoire of T-cell receptors (TCR) plays a key role in the adaptive immune response to infections.

221 The linker in a drug conjugate plays a key role in the circulation time of the conjugate and re

222 and in particular diet, are known to play a key role in the development of Coronary Heart Disease.

223 albumin-expressing (PV+) interneurons play a key role in the maturation and synchronization of cortic

224 erall, these data reveal that S100A6 plays a key role in the PPP5C-FKBP51 axis to inhibit I(SOC) and

225 ive complement system-the complosome-and its key role in the regulation of cell metabolic pathways th

226 such as the iron sulfide mackinawite, play a key role in the remediation of uranium from groundwater

227 Well-characterized antibody reagents play a key role in the reproducibility of research findings, an

228 emonstrate that exonuclease 1 (EXO1) plays a key role in the resolution of, and replication through,

229 tes in subglacial environments, which play a key role in trace elemental cycles, with potentially imp

230 The findings suggest a key role of cardiac Orai1 channels and the potential for

231 Our results showcase the key role of plant root traits, especially root diameter,

232 r behavior encoded in our record reveals the key role that polar ice volume plays in the predictabili

233 We hypothesized that IDO could play a key role to locally regulate cardiac homeostasis after M

234 SP) medium spiny neurons (MSNs) as playing a key role.

235 by the realization that this metabolite has key roles in cells beyond the muscle and brain.

236 Receptor-like protein kinases (RLKs) play key roles in regulating plant growth, development and st

237 We focus on four key rules of life and their interactions: the temperatur

238 into cyclic guanosine-3',5'-monophosphate, a key second messenger in cell signaling and tissue homeos

239 , 0.69 [95% CI, 0.59-0.80]; P=0.000001); the key secondary composite end point occurred in 16.6% vers

240 Here we report the key secondary efficacy endpoint of the proportion of par

241 Key secondary endpoints were overall survival, event-fre

242 bitual behavior, and our research provides a key set of results showing "when" it is important (i.e.,

243 urb the overall conformation of backbone and key side-chain residues.

244 ls that is poised to orchestrate assembly of key signaling components upon reception of an extracellu

245 enhancer of activated B cells (NF-kappaB) as key signaling pathways in NFKBIZ/IkappaBzeta regulation.

246 t women were clustered geographically and by key sociodemographic factors.

247 NK cells are likely key sources of IFN-gamma in this model.

248 e color change and shelter seeking, became a key species of interest [4, 8, 9].

249 with collection of quality data, identifying key stakeholders and bringing them on board to ensure th

250 awareness among critical care clinicians and key stakeholders, advocating for workplace changes to pr

251 rface reveals that the cyclization step is a key step controlling the selectivity of the process.

252 A key step during HCMV reactivation in latently infected H

253 ision of a cell into two daughter cells-is a key step in cell growth and proliferation.

254 , the present study establishes that another key step in central metabolism is poisoned by molecular

255 Molecular recognition of carbohydrates is a key step in essential biological processes.

256 fter ligand perception is considered to be a key step in KAR/KL signaling.

257 cleolytic resection of DSB-adjacent DNA is a key step in meiotic DSB repair, but this process has rem

258 Our result offer insight into a key step in substrate ubiquitination by a member of the

259 y of a closed protein shell (or capsid) is a key step in the replication of viruses and in the produc

260 It was then successfully applied as the key step in the synthesis of the natural product lamella

261 A key step of an automated computational design algorithm

262 ificial atoms into phase-stable PICs marks a key step towards multiplexed quantum repeaters(7,8) and

263 four-component Ugi reaction (Ugi-4CR) as the key step.

264 One of the key steps in the assay is converting unmethylated cytosi

265 lso found that BAIAP2L2 interacts with other key stereociliary proteins involved in normal hair bundl

266 The key strategy used for this novel synthesis is the facile

267 Exopolysaccharides are key structural components of this matrix and are require

268 erstanding of their function and elucidating key structural motifs that can be targeted for therapeut

269 whether heterogeneity in phosphorylation of key structural proteins alters tissue integrity and orga

270 y, encodes TTN (titin), a protein that plays key structural, developmental, and regulatory roles in s

271 s) have emerged as fascinating materials and key structures for electrocatalysis.

272 Here, we highlight key studies testing intrinsic and extrinsic hypotheses a

273 and somatic genomic alterations and are thus key targets for cancer chemoprevention.

274 ence lifetime imaging microscopy (FLIM) is a key technology that provides direct insight into cell me

275 To address how interactions between four key TFs contribute to cis-regulation in mouse ESCs, we a

276 A key therapeutic target in PD is alpha-synuclein (alphaS)

277 The effective reproduction number, Rt, is a key time-varying prognostic for the growth rate of any i

278 ctions, isolation of infected individuals is key to curtailing transmission.

279 argest anthropogenic CO(2) emissions and are key to effective emission reduction strategies.

280 uely amenable to ssNMR, thus appears to be a key to explaining other macroscopic properties, such as

281 es the use of resilience mechanisms that are key to mental health outcomes in the face of adversity.

282 fundamental understanding of film formation, key to optimizing these devices, is lacking.

283 graphene, mechanical exfoliation has been a key to provide high-quality two-dimensional materials, b

284 election of effective and safe dosage is the key to sparing local therapy.

285 The key to success was the use of weakly coordinating amide

286 odies of peptide-MHC-II interaction data are key to the solution of this problem, a solution that als

287 Key to the synthesis are stereocontrolled 1,4-semihydrog

288 The fossil record is key to this problem, as it provides data on repetitive t

289 ce that systemic uptake of food allergens is key to triggering anaphylaxis.

290 learning models and segregation database are key to unlocking the full potential of GB segregation as

291 notypic plasticity and genetic adaption, the keys to resistance.

292 kground resulted from OmpR repression of the key ToxR regulon virulence activator aphB, and ompR over

293 protein particle (TRAPP) complexes regulate key trafficking events and are required for autophagy.

294 ll identity through fine-tuned regulation of key transcription factors ensures beta-cell function.

295 A key unanswered question is whether infection with SARS-C

296 is Network (GTN) aims to conduct research on key unmet therapeutic and diagnostic needs in the field

297 The key UPR sensor IRE1alpha resides in the ER and deploys a

298 ide evidence that a signaling axis involving key UPS components contributes to oligodendrocyte develo

299 cities, this empirical study identifies the key urban form determinants of decadal-long fine particu

300 In this study, we found that another key virulence regulator, ToxR, was important for V. chol