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1 r diseases and Beclin1 (BECN1) is one of its key regulators.
2 ations, assess network topology and identify key regulators.
3 os (ATOH1, ATOH7, ATOH8, NEUROD1) emerged as key regulators, acting upstream of core components of th
6 een proposed to explain interactions between key regulators and transduction of germinant and cogermi
7 cell compartments with downregulation of Th2 key regulators and upregulation of Treg transcription fa
9 tory modules at each time point, to identify key regulators driving changes of the cellular state, an
11 Here, we identified the TF C/EBPbeta as a key regulator for DC maturation and immunogenic function
12 In mice genetically deficient in gastrin, a key regulator for gastric acid production, or pharmacolo
13 the cyclin-dependent phosphatase CDC25A is a key regulator for NIP30 phosphorylation and modulation o
14 ein and is down-regulated in PD brains, as a key regulator functionally connected to known PD risk ge
15 ese findings strongly implicate TSPAN-7 as a key regulator in determining the set-point of glucose-st
17 findings uncover a novel role for Vgl1 as a key regulator in heterochromatin-mediated gene silencing
18 ably by decreasing the expression of PAX6, a key regulator in the development of human neuroectoderm.
19 ong noncoding RNAs (lncRNAs) have emerged as key regulators in a variety of cellular processes that i
24 ding proteins like human antigen R (HuR) are key regulators in post-transcriptional control of gene e
35 gether, our data demonstrate that SRSF3 is a key regulator of AS in GBM and that understanding mechan
38 sophila screen, we identified ref(2)P/p62, a key regulator of autophagy, as a potent suppressor of ne
39 artite motif protein 23 (TRIM23), which is a key regulator of autophagy-mediated antiviral defense me
41 Together, these results establish BMP5 as a key regulator of basal prostate stem cell homeostasis an
42 es OX-A and OX-B, is firmly established as a key regulator of behavioral arousal, sleep, and wakefuln
43 response to glucose, a beta-cell mitogen and key regulator of beta-cell mass in response to increased
46 els of parathyroid hormone (PTH), which is a key regulator of bone metabolism but also of HSC activit
47 that this amygdalo-parabrachial pathway is a key regulator of both chronic and acute pain, and a nove
48 ver, serotonin (5-HT) has been shown to be a key regulator of both facial-emotion processing and brai
49 , but the DSB-responsive kinase ATM proved a key regulator of both initiation and extension of resect
50 s calcium-dependent protein kinase CPK3 is a key regulator of both pattern-triggered immunity and eff
51 that the dynamics of presented antigen is a key regulator of both the size and specificity of the ad
52 dulin-dependent phosphatase calcineurin is a key regulator of cardiac myocyte hypertrophy in disease.
57 ogene PTPN11 and is a ubiquitously expressed key regulator of cell signaling, acting on a number of c
58 endent protein kinase kinase-2 (CaMKK2) is a key regulator of cellular and whole-body energy metaboli
62 ify how the Na(+)/H(+)-exchanger 1 (NHE1), a key regulator of cellular pH homeostasis, is regulated b
66 en ARC3 and PARALOG OF ARC6 (PARC6), another key regulator of chloroplast division, suggesting a role
69 r GDE3 in gliogenesis and identify GDE3 as a key regulator of CNTF-dependent regulation of OPC prolif
70 dy demonstrates interaction variability as a key regulator of community dynamics, providing insights
72 smic linker-associated protein 2 (CLASP2), a key regulator of cortical capture and stabilization of M
73 Overall, our work demonstrates Nrp2 to be a key regulator of corticostriatal development, maintenanc
74 that the CRC-associated lncRNA PVT1-214 is a key regulator of CRC development and progression; patien
75 od, although NTA has gained recognition as a key regulator of crucial processes such as protein turno
77 ether, these results suggest that Tiam1 is a key regulator of DG granule cell stabilization and funct
78 ed for these domains in the paralog USP11, a key regulator of DNA double-strand break repair by homol
80 TATEMENT The dopamine transporter (DAT) is a key regulator of dopamine neurotransmission and a target
85 AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism that phosphorylates a
87 -inducible deletion of ER chaperone Grp78, a key regulator of ER homeostasis, in alveolar type II (AT
89 r data reveal the p38 MAPK-MK2-TTP axis as a key regulator of expression of ARE-bearing mRNAs that pr
93 apsella rubella controls the activity of the key regulator of fruit development, INDEHISCENT (CrIND i
96 ion initiation factor 4E (EIF-4E) protein, a key regulator of gene translation and protein function,
99 ulate glucose consumption and that CDK7 is a key regulator of glucose consumption in cells with an ac
100 response element binding protein (ChREBP), a key regulator of glycolysis and de novo lipogenesis, is
101 within the GI tract, positioning GM-CSF as a key regulator of GVHD in the colon and a potential thera
105 f S1P formation in the nucleus by SphK2 is a key regulator of HIF functions, we found using a preclin
107 n, we studied the effects of HA content as a key regulator of human astrocyte (HAf) reactivity using
110 riguingly, we furthermore identified NRF2 as key regulator of immune-modulating genes, linking oxidat
111 ription factor (TF) Bhlhe40 is emerging as a key regulator of immunity during infection, autoimmunity
112 ctor kappa B (NF-kappaB) signaling system, a key regulator of immunologic processes, also affects a p
114 lasmic reticulum aminopeptidase 1 (ERAP1), a key regulator of innate and adaptive antitumor immune re
116 senger complex (CPC) localizes to and is the key regulator of inner centromere organization and funct
118 re, we show that the expression of talin1, a key regulator of integrins and cell adhesions, negativel
120 mponent of the innate immune response, are a key regulator of intestinal microenvironment homeostasis
122 e that the mechanism of action of TMPRSS6, a key regulator of iron homeostasis, may differ from early
124 n convertase subtilisin/kexin 9 (PCSK9) is a key regulator of lipid metabolism by degrading liver LDL
125 We then apply EIG to identify A1CF as a key regulator of liver-specific alternative splicing, su
126 onvertase subtilisin/kexin type 9 (PCSK9), a key regulator of low-density lipoprotein metabolism, is
127 These data suggest that peptide YY is a key regulator of macronutrient absorption in the small i
129 ollectively, our work identifies MCM8IP as a key regulator of MCM8-9-dependent DNA synthesis during D
130 They include the entire Nodal pathway, a key regulator of mesoderm development and left-right axi
134 protein-C (cMyBP-C) has been recognized as a key regulator of myocardial contractility, little is kno
135 after genetic knock-down of RIPK3, a second key regulator of necroptosis, and the downstream effecto
136 hat proximity to microtubule tracks may be a key regulator of neurofilament transport in axons, which
137 n molecule remodeling; (2) neuroligin-3 is a key regulator of neuroligin cleavage events; and (3) the
138 tide exchange factor (RhoGEF) TRIO acts as a key regulator of neuronal migration, axonal outgrowth, a
139 idase-deficient mice, we show that TSPO is a key regulator of NOX1-dependent neurotoxic ROS productio
140 emains unclear whether altered metabolism, a key regulator of NSPC activity, disrupts human neurogene
143 role of the action potential amplitude as a key regulator of pancreatic islet hormone secretion.
144 dulin-dependent phosphatase calcineurin is a key regulator of pathological cardiac hypertrophy whose
145 er, our findings reveal that KDM5B acts as a key regulator of PI3K/AKT signaling; they also support t
146 se subtilisin-like/kexin type 9 (PCSK9) is a key regulator of plasma LDL-cholesterol (LDL-C) and a cl
147 m through ectopic production of WRINKLED1, a key regulator of plastid fatty acid biosynthesis, and a
151 how that the strength of PI3K signaling is a key regulator of pregerminal center B cell self-toleranc
155 Our findings reveal a role of Zn(2+) as a key regulator of protein quality control at the ER-Golgi
156 n of proteins with the lipid palmitate, is a key regulator of protein targeting and trafficking.
158 iption factors and NADPH oxidase 4 (Nox4), a key regulator of reactive oxygen species production.
161 y the gene Tubby-like protein-3 (Tulp3) as a key regulator of renal cystic disease from a forward gen
162 reveal LARP6-mediated mRNA localization as a key regulator of ribosome biogenesis during cell migrati
163 e, we identify that a CK2/HAUSP pathway is a key regulator of RUNX2 stability, as Casein kinase 2 (CK
164 ndings highlight the importance of tilt as a key regulator of size and morphology of membrane-bound o
165 xide synthase (nNOS) in skeletal muscle is a key regulator of skeletal muscle mass; however, it is un
168 omotes nuclear activation of sbp-1/ SREBP, a key regulator of sterol and fatty acid synthesis, to res
169 e for fungal pathogens, for which Hsp90 is a key regulator of stress tolerance, drug resistance, and
170 esults identify the miR-106b~25 cluster as a key regulator of stress-induced inflammation and depress
174 he Tc-foxQ2 forkhead transcription factor, a key regulator of the anterior gene regulatory network of
176 ether, our findings suggest that PABPN1 is a key regulator of the C-terminal p63 isoforms through APA
182 we examined the impact of IL-1 signaling, a key regulator of the IL-17 pathway, in different cell ty
185 ulator of interferon genes (STING) protein-a key regulator of the innate immune response to cytosolic
187 urotrophin receptor (CD271/NGFR/p75NTR) is a key regulator of the melanocytic cell lineage through it
188 rain-derived neurotrophic factor (BDNF) is a key regulator of the morphology and connectivity of cent
189 By using a knockout (KO) mouse for MKK3, a key regulator of the p38MAPK pathway, we showed that thi
192 Here we identify the Yap/Tead complex as a key regulator of the self-renewal gene network in organ
194 we show that the activin receptor ALK4 is a key regulator of the specification of somatostatin inter
199 bcellular localization of RP-mRNAs acts as a key regulator of their translation during cell migration
200 ated homeobox transcription factor DWT1 is a key regulator of this important agronomic trait, disrupt
205 ssenger RNA-decapping enzyme 1A (DCP1A) as a key regulator of Tsix, a noncoding RNA implicated in all
206 (a disintegrin and metalloprotease 17) is a key regulator of tumor necrosis factor alpha (TNFalpha),
209 ry, our findings identify platelet GPVI as a key regulator of vascular integrity specifically in grow
210 e human papillomavirus (HPV) E2 protein is a key regulator of viral transcription and replication.
212 of cisplatin requires activation of Sarm1, a key regulator of Wallerian degeneration, as mice lacking
213 the past decade has identified satellites as key regulators of a wide range of cellular and organisma
214 Circular RNAs (circRNAs) have emerged as key regulators of a wide variety of biological processes
215 RING fingers (RBR)-type RSL1/RFA family, are key regulators of ABA receptor stability in root and lea
216 j16 identifies Kir5.1-containing channels as key regulators of acute and chronic pH homeostasis.
218 and cytidine residues, are now recognized as key regulators of both cellular and viral mRNA function.
220 eart remain unclear, B cells are emerging as key regulators of cardiovascular adaptation to injury.
221 a(1D)-adrenergic receptors (alpha(1D)-ARs) - key regulators of cardiovascular and central nervous sys
222 an clock genes can control the expression of key regulators of cell cycle progression and therefore c
224 ed protein tyrosine phosphatases (RPTPs) are key regulators of cell-cell communication through the co
228 a(1D)-adrenergic receptors (alpha(1D)-ARs) - key regulators of central and autonomic nervous system f
230 thase (GLUL) and the gamma-glutamyl cycle as key regulators of CHD risk in diabetes, and the identifi
236 ) and its mammalian homolog Cdh1 function as key regulators of endoreplication entrance by activating
239 les in tumor growth and progression, however key regulators of gene expression in the TME of cutaneou
240 RBPs) and long non-coding RNAs (lncRNAs) are key regulators of gene expression, but their joint funct
241 oding RNAs (ncRNA) are emerging as versatile key regulators of gene information involved in multiple
242 gonadal histology and altered expression of key regulators of gonadal growth and steroidogenesis.
243 n signatures that are enriched in binding of key regulators of hematopoiesis and AML pathogenesis.
244 homeobox gene family, appeared as one of the key regulators of hematopoietic stem cell (HSC) self-ren
245 s providing ligands for nuclear receptors as key regulators of hepatic bile acid (BA)/lipid metabolis
246 t content and nutrient timing are considered key regulators of human health and a variety of diseases
249 e treatment of various diseases, as they are key regulators of inflammation as well as lipid and gluc
250 nscription factor E3 (TFE3), are emerging as key regulators of innate immunity and inflammation.
252 ters of millet SCR1, GNC, and AN3, which are key regulators of Kranz anatomy, chloroplast development
253 cells and markedly suppressed expression of key regulators of lineage commitment and neurogenesis (R
254 atidylinositol-transfer proteins (PITPs) are key regulators of lipid signaling in eukaryotic cells.
255 gical procedure further our understanding of key regulators of liver regeneration as well as patient
256 le that includes incomplete demethylation of key regulators of meiosis and transposable elements.
257 The results identify Cys201 and Cys208 as key regulators of MGL function and point to the BTZ scaf
258 alcium and reactive oxygen species, are also key regulators of mitochondrial cell death pathways.
259 isplays a reciprocal expression pattern with key regulators of neural crest delamination, Phf12 and S
261 ine action.SIGNIFICANCE STATEMENT NMDARs are key regulators of neurodevelopment and synaptic plastici
267 nc finger transcription factors, function as key regulators of several biological processes important
268 ein signaling (RGS) proteins have emerged as key regulators of signaling through G protein-coupled re
270 oblast growth factor homologous factors) are key regulators of sodium channel (Na(V)) inactivation.
271 to be present in gastruloids, and show that key regulators of somitogenesis are expressed similarly
272 e adult, modulate sleep homeostasis, and are key regulators of synaptic integrity in the RTN region,
274 Gap junctions and connexin hemichannels are key regulators of the biology of neural progenitors duri
276 YAP as a broad transcriptional repressor of key regulators of the cell cycle, in turn influencing co
279 tically, PKCzeta, ERK1/2, mTOR, and PP2A are key regulators of the Myc response in this setting.
280 es that PARP-mediated ADPRylation events are key regulators of the protein biosynthetic pathway, lead
281 Mechanistically, GATA6 directly activates key regulators of the SAN genetic program in conduction
283 racellular stimuli, have recently emerged as key regulators of the Warburg effect during tumorigenesi
285 n-neoplastic monocytic cells have emerged as key regulators of tumor maintenance and progression.
286 ignalling pathways have therefore emerged as key regulators of tumour growth and metastasis as well a
289 ted that CDCP1 promotes translocation of the key regulators of Wnt signaling, beta-catenin, and E-cad
291 Cohesin and CTCF (CCCTC-binding factor) are key regulators; perturbing the levels of either greatly
292 tion, and mitochondrial biogenesis and their key regulator Ppargc1a Overnutrition worsened excitotoxi
294 poxia-inducible factor alpha (HIFalpha) is a key regulator that adapts neural cells to physiological
297 spatiotemporal localization dynamics of the key regulators that master the two intertwined and trans
298 roRNAs (miRNAs) are noncoding and endogenous key regulators that play significant functions in regula
299 proposed working model, optineurin acts as a key regulator to link inhibition of KRAS signaling and c