ライフサイエンスコーパス: key step

1 ar resorcinarene capsule as catalyst for the key step.

2 an underutilized Ichikawa rearrangement as a key step.

3 nucleophilic addition to the amide bond as a key step.

4 rmylcoumarin and tetrahydroisoquinoline as a key step.

5 ng Pd(0)-catalyzed C(sp(3))-H arylation as a key step.

6 urity using Sharpless dihydroxylation as the key step.

7 alyzed cyclization of aryl alkynoates as the key step.

8 hieved a microwave glycosylation method as a key step.

9 four-component Ugi reaction (Ugi-4CR) as the key step.

10 stereoselective 1,3-dipolar cycloaddition as key steps.

11 obsen's hydrolytic kinetic resolution as the key steps.

12 on of the subsequent 1,2-aryldiamines as the key steps.

13 Sonogashira coupling and Boland reduction as key steps.

14 nation of tetrabromonorbornane (-)-5a as the key steps.

15 (I)-catalyzed cyclocarbonylation reaction as key steps.

16 nt metathesis and ring-closing metathesis as key steps.

17 The synthetic procedure involved two key steps: (1) the reaction of vinyl magnesium bromide w

18 azasordarin analogs was synthesized using as key steps a Diels-Alder reaction to generate a highly su

19 The synthesis features the following three key steps: (a) a regioselective Pictet-Spengler reaction

20 dissect the regulatory forces underpinning a key step along the developmental decision-making cascade

21 rviews were conducted in round 1 to identify key steps and tasks, which were rated as mandatory, opti

22 olving hydroamination or C-H activation as a key step are largely excluded.

23 Its key steps are a purpurogallin-type (5 + 2)-cycloaddition

24 in children with newly diagnosed T1DM, three key steps are necessary: the generation of a predictive

25 Iodine triacetate is employed in a key step as a highly selective and efficient iodinating

26 lent when formamides are used to trigger the key step, bearing either an electron-rich aryl or a pyrr

27 s suggest a radical chain mechanism with the key step being a homolytic aromatic substitution of the

28 The key step comprises the aldol addition of 3,3-disubstitut

29 The key step consists of the one-pot Diels-Alder trapping of

30 rface reveals that the cyclization step is a key step controlling the selectivity of the process.

31 ia [Co(III)-O(2)(*)](-) is identified as the key step determining the selectivity of water oxidation.

32 A key step during HCMV reactivation in latently infected H

33 he tetrapod limb, and their positioning is a key step during limb development.

34 that the formation of the SNARE complex is a key step during membrane fusion.

35 Crushing is a key step during olive oil extraction.

36 he assumption that oxidative addition is the key step during the cross-coupling reaction of aryl hali

37 A key step during the metastatic journey of the cancer cel

38 nscription factor 15 (KLF15), which regulate key steps during embryo implantation, cooperate to stimu

39 d molecular dynamics simulations, we resolve key steps during PLY pore formation.

40 ccessfully prepared using this protocol as a key step, emphasizing its potential utility in medicinal

41 cular focus on egress from infected cells, a key step for balancing survival, multiplication, and spr

42 -O bonds without breaking C-C/C-H bonds is a key step for catalytic conversion of renewable biomass t

43 ts the dynamics of the competing species-the key step for completing the required eco-evolutionary fe

44 metabolites in monolignol biosynthesis is a key step for controlling lignin content, structure, and

45 .1/Kir5.1 induced by high sodium intake is a key step for downregulation of NCC.

46 natural functional monomer(s) represents the key step for efficient imprinting of biomolecules.

47 S)-4-cyano-1-aminoindane then represents the key step for introducing the chirality and the desired a

48 Cell polarization is a key step for leukocytes adhesion and transmigration duri

49 The isomerization reaction is the key step for obtaining the ketones in their enantioenric

50 n easy scaling up of the process: the first, key step for practical application of nanosized rare-ear

51 llowing events in cervical auscultation is a key step for swallowing analysis to be clinically effect

52 ion/aryl migration of azido complexes as the key step for the in situ generation of carbodiimidium io

53 tion proceeding via the endo-fashion was the key step for the transition-metal-free and mild cross-de

54 s of membrane protein function and represent key steps for advancing structure-guided inhibitor desig

55 l of interface ligand barriers is one of the key steps for efficient carrier transportation in optoel

56 The two key steps for optimization were (i) a core morph guided

57 Here, we reveal key steps for the pro-motion of this reaction by water w

58 However, the key step governing its activation remains elusive.

59 olar-crossover cascade entails the following key steps: (i) beta C-H iodination via 1,5-hydrogen atom

60 or pathways A1, A2, B1, and B2, comprise two key steps: (i) the formation of ethyl hydroperoxide (EHP

61 of a Lewis acidic borane with an alkyne is a key step in a diverse range of main group transformation

62 A key step in achieving this goal is the separation of lon

63 ts that may mislead downstream analyses is a key step in analyzing single-cell RNA-sequencing (scRNA-

64 Body-axis elongation constitutes a key step in animal development, laying out the final for

65 mbrane source for LC3 lipidation, which is a key step in autophagosome biogenesis.

66 A key step in bacteriochlorophyll biosynthesis is the redu

67 A key step in bacteriochlorophyll biosynthesis is the redu

68 erase gene negatively impacts sporulation, a key step in C. difficile disease transmission, and these

69 ision of a cell into two daughter cells-is a key step in cell growth and proliferation.

70 orage form, cholesteryl esters, regulating a key step in cellular cholesterol homeostasis.

71 , the present study establishes that another key step in central metabolism is poisoned by molecular

72 d fractured by those same forces, which is a key step in centrosome disassembly.

73 rsion of squalene to 2,3(S)-oxidosqualene, a key step in cholesterol biosynthesis.

74 smic translocation of core clock proteins, a key step in circadian timekeeping, is not fully understo

75 loci for chromatin accessibility (caQTLs)-a key step in cis-regulation-in 1000 individuals from 10 d

76 A key step in crosslink repair is monoubiquitination of th

77 ccupancy of transcription factors (TFs) is a key step in deciphering developmental transcriptional pr

78 mRNA translation is a key step in decoding genetic information.

79 iption factor (TF) (its 'target genes') is a key step in developing a comprehensive understanding of

80 A key step in developing genetic regulatory network analog

81 A key step in domestication of the grapevine was the trans

82 A key step in drug combination analysis is the selection o

83 Molecular recognition of carbohydrates is a key step in essential biological processes.

84 Alternative splicing is a key step in eukaryotic gene expression that allows for t

85 non-coding variants on candidate genes is a key step in evaluating their clinical significance.

86 A key step in expanding our biochemical vocabulary is to r

87 oselective methylation step is shown to be a key step in formation of the ortho-hydroquinone.

88 scriptional regulation of RNA stability is a key step in gene expression control.

89 Gene is a key step in genome annotation.

90 late cells (HSCs) in response to injury is a key step in hepatic fibrosis, and is characterized by tr

91 n that pulls HIV into the nucleus explains a key step in HIV infection.

92 RAD51AP1 is critical for D-loop formation, a key step in homologous recombination.

93 ion of patients at risk for readmission is a key step in improving disease management and patient out

94 Integrating objects with their context is a key step in interpreting complex visual scenes.

95 fter ligand perception is considered to be a key step in KAR/KL signaling.

96 HSC activation is a key step in liver fibrogenesis and has a crucial role in

97 mputational prediction of gene function is a key step in making full use of newly sequenced genomes.

98 rong sp(3) C-H bonds at mild conditions is a key step in many biological and synthetic transformation

99 cleolytic resection of DSB-adjacent DNA is a key step in meiotic DSB repair, but this process has rem

100 ion is industrially important as well as the key step in methanol steam reforming on gold catalysts.

101 of inorganic divalent mercury (Hg(II)) is a key step in microbial formation of neurotoxic methylmerc

102 ectures of functional organic molecules is a key step in nature for converting sunlight into a useful

103 terminal nitride from coordinated ammonia, a key step in NH3 oxidation.

104 l halides has been extensively proposed as a key step in Ni-catalyzed cross-coupling reactions to gen

105 their cognate ligands or receptors and is a key step in niche or host colonization and pathogenicity

106 During influenza virus infection, a key step in PANoptosis and PANoptosome assembly is the f

107 Lignin removal is a key step in paper production and biomass conversion to b

108 cells induces ciliary translocation of Smo-a key step in pathway activation-in the absence of Hh.

109 Light harvesting is a key step in photosynthesis but creation of synthetic lig

110 ements interacting at promoter regions, is a key step in plant responses to environmental cues.

111 linical-grade peptides on demand, which is a key step in reaching the full potential of personalized

112 e propose that prophase cohesin removal is a key step in reprogramming gene expression as cells trans

113 rotein-coding mRNAs (RP-mRNAs) constitutes a key step in ribosome biogenesis, but the mechanisms that

114 or Golgi-to-plasma membrane trafficking is a key step in secretion.

115 Library preparation is a key step in sequencing.

116 sm that controls myoblast differentiation, a key step in skeletal muscle formation.

117 Our result offer insight into a key step in substrate ubiquitination by a member of the

118 PSases catalyze the key step in the biosynthesis of indole and benzylisoquin

119 Through this effort, we have elucidated a key step in the biosynthesis of the paraherquamides and

120 ivatives and N-alpha-trimethylhistidine as a key step in the biosynthesis of thiohistidines.

121 y electrocyclization process elucidating the key step in the catalytic process.

122 of new genomes with nucleotide precision, a key step in the convergent synthesis of genomes from div

123 ion in renewable fuel cell development and a key step in the development of aerobic oxidation reactio

124 of a protein's conformational stability is a key step in the development of biotherapeutics, where pr

125 with greater specificity against hRRM1 is a key step in the development of more effective treatments

126 ductive cleavage of aryl ether linkages is a key step in the disassembly of lignin to its monolignol

127 A key step in the Ebola virus (EBOV) replication cycle inv

128 Pseudogenization of PfEBA165 may represent a key step in the emergence and evolution of P. falciparum

129 A key step in the establishment of infection is the integr

130 show that a human-like transverse arch was a key step in the evolution of human bipedalism that preda

131 the multicellular body plan and constitute a key step in the evolution of morphological complexity.

132 Our results provide insights into a key step in the FA pathway and help define the multiface

133 The key step in the first-generation approach involves the c

134 growth in petioles, this study identifies a key step in the gene regulatory network controlling leaf

135 and phytoplankton in the surface ocean is a key step in the global carbon cycle, with almost half of

136 ion of the mitochondrial outer membrane is a key step in the intrinsic apoptosis pathway, triggered b

137 The results presented here uncover a key step in the molecular mechanism of SCN resistance, a

138 se activity, encoded by the gene DODA, was a key step in the origin of betalain biosynthesis in Caryo

139 urotoxicity has been generally accepted as a key step in the pathogenesis of Parkinson's disease (PD)

140 Support is included for the key step in the process, reduction of U(VI) to U(V) .

141 A key step in the production of infectious virions is the

142 The key step in the reaction mechanism is a 1,3-chlorine shi

143 trol at the level of translation, which is a key step in the regulation of gene expression, as eviden

144 Translation initiation is a key step in the regulation of gene expression.

145 y of a closed protein shell (or capsid) is a key step in the replication of viruses and in the produc

146 A stereoselective Mukaiyama hydration is the key step in the subsequent elaboration of the cis-2,8-di

147 The key step in the synthesis of both bruceol and isobruceol

148 It was then successfully applied as the key step in the synthesis of the natural product lamella

149 to the corresponding S-aryl derivatives, the key step in the synthesis of thiophenols from the corres

150 The key step in these syntheses involve a Rh-catalyzed C-C/C

151 rent state of the art) and in CT (an unusual key step in this approach) has the potential to improve

152 A key step in this process is the in silico design of sing

153 One key step in this quality control is assessment of DNA da

154 The key step in this transformation involves in situ generat

155 Left ventricular (LV) dilatation is a key step in transition to heart failure (HF) in response

156 This is a key step in translational control and must be tightly re

157 A key step in translational initiation is the recruitment

158 Key steps in a computational study of protein function i

159 catalyzes the replication of DNA, one of the key steps in cell division.

160 h spin upon substrate addition is one of the key steps in cytochrome P450 catalysis.

161 tic events, providing detailed insights into key steps in early apoptosis.

162 to cause insulin resistance, dysfunction of key steps in hepatic lipid metabolism, atherosclerosis,

163 Key steps in model development and validation were frequ

164 in yeast facilitated the characterization of key steps in Muta1 transposition.

165 Here, we summarize the key steps in oral microbial colonization that should be

166 We summarize key steps in preclinical development and subsequent tran

167 ditis elegans as a model animal to elucidate key steps in RQ biosynthesis.

168 -pentacene interactions and, in turn, on the key steps in singlet fission (SF), that is, the (1)(S(1)

169 One of the key steps in the assay is converting unmethylated cytosi

170 These studies establish several key steps in the assembly of the thioheptose core during

171 tudies, there are gaps in the elucidation of key steps in the catalytic cycle of kinesin.

172 Transcription and pre-mRNA splicing are key steps in the control of gene expression and mutation

173 eta-carotene hydroxylase 2 (ZmBCH2) controls key steps in the conversion of beta-carotene to zeaxanth

174 physical methods enable the deconvolution of key steps in the Cyt1Aa bioactivation cascade.

175 The purposes of this statement are to review key steps in the development of a meta-analysis and to p

176 These changes may impact key steps in the development of the infant gut microbiom

177 that offers direct evidence for the initial key steps in the evolution of the cercopithecoid dentiti

178 Key steps in the functionalization of an unactivated are

179 to assess user comprehension of each of the key steps in the label.

180 The two key steps in the MARA algorithm are the separation of th

181 Key steps in the synthesis are a highly stereoselective

182 One of the key steps in the synthesis of chromane is metal-free gen

183 Key steps in the synthetic route include kinetic protona

184 Similar key steps in the transcription cycle can be targeted by

185 t acting antiviral agents (DAAs) that target key steps in the viral life cycle.

186 apsid formation and RNA replication, housing key steps in the virus life cycle that warrant further i

187 The key steps in this approach included esterification, Frie

188 The other key steps in this approach included Sonogashira coupling

189 Key steps in this modular six-step sequence include a DM

190 e compared to model-based approaches for two key steps in TRMN prediction, namely somatic variant cal

191 The key steps include a unique highly diastereoselective FeC

192 (IDTs) were successfully synthesized by two key steps, including polysubstituted olefin formation an

193 The key steps involve a highly stereoselective substrate-con

194 The key steps involve an efficient Paterno-Buchi [2 + 2] pho

195 Key steps involve the (i) Vollhardt cyclization of bis(p

196 The key step involved enzyme-catalyzed ester hydrolysis in g

197 The key step involved sequential Suzuki couplings of a nonsy

198 corroborate their structures and to explain key steps involved in the biogenetic mechanisms proposed

199 Key steps involved polyketide aromatization of a trans,

200 The key step involves a highly alpha(2,3)-stereoselective si

201 In both approaches, the key step is based on the cyclization of a (tris)lithio-t

202 The key step is the activation of a bicyclic iminoglycal car

203 A key step is the formation of the division boundary along

204 this is impossible if [Formula: see text] A key step is to distinguish when nodes can become aware o

205 clization of the corresponding triene 2 as a key step leading to a heptacyclic aromatic system.

206 ium-dependent relaxation (EDR) is an initial key step leading to various vascular complications in pa

207 ladation of suitable Ugi-4CR substrates as a key step leads to the regio- and diastereoselective form

208 spite the high temperatures employed in this key step, no conformational scrambling was observed duri

209 A key step of an automated computational design algorithm

210 tal cells, in a tissue specific manner, as a key step of cancer progression and pre-metastatic niche

211 This method forms a key step of de novo characterization of nucleotide modif

212 (II)(Xant)Si(II)] ligand are involved in the key step of H2 cleavage and hydrogen transfer to the ole

213 Here, we provide first insight into the key step of MSP-mediated phosphotransfer in a eukaryotic

214 A key step of our concise route is a late-stage, highly di

215 ion by RNA polymerase I (Pol I) is the first key step of ribosome biogenesis.

216 However, the key step of the C-C bond formation needed for the genera

217 mine to the N-acetyl-lactosamine repeat as a key step of the chain elongation process.

218 Mechanistic interrogation of each key step of the methodology informs its practical applic

219 The key step of the proposed strategy is base-mediated cycli

220 The key step of the reaction sequence included a [3 + 2] cyc

221 because they enhance the understanding of a key step of the rotavirus replication cycle.

222 The key step of the synthetic sequence included cyclization

223 The key step of the synthetic sequence included deoxofluorin

224 The key step of this approach is an epimerization of C5 by a

225 terium labeling studies established that the key step of this cascade involves a novel base-mediated

226 )-dependent dehydrogenase (AHGD), which is a key step of this pathway.

227 ively inhibit hydrogen evolution reaction, a key step of water decomposition during the charging proc

228 scularized tumor models are created to mimic key steps of cancer dissemination (invasion, intravasati

229 Key steps of cardiac mechanochemistry, including the for

230 As, we identify numerous lncRNAs involved in key steps of cell division such as chromosome segregatio

231 ial intelligence (AI) can be used to reshape key steps of clinical trial design towards increasing tr

232 range of quality control metrics for several key steps of experimental protocols, with a flexible cho

233 In this work, the key steps of fullerene recognition and binding processes

234 tiva), and unravel their regulatory roles in key steps of reproductive development.

235 e targeting of distinct chromatin states and key steps of RNA Pol II-mediated transcription in cancer

236 Key steps of synthesis were (i) diastereoselective nucle

237 (Arabidopsis thaliana) mutants deficient in key steps of the PAO/phyllobilin pathway, we show an una

238 hanistic scenarios were investigated for the key steps of the reaction, which are the enolate transme

239 The key steps of the synthesis include a stereoselective vin

240 Key steps of the synthesis included the Negishi coupling

241 The key steps of the synthetic sequence (11 steps, 46% globa

242 The key steps of the transformation are the formation of nuc

243 dissect the molecular mechanisms underlying key steps of the VACV life cycle, such as binding, penet

244 , our discovery of an alloyed memristor is a key step paving the way beyond von Neumann computing.

245 and [2 + 2] photocycloaddition reactions as key steps, provides a general access to 4-alkyl lactones

246 Therefore, we reveal a key step regulating hypoxic angiogenesis and highlight t

247 remain a topic of intense research, however, key steps remain to be elucidated, especially those that

248 The key step represented a regioselective coupling of a dibr

249 U.1 and GATA2 in the fetal liver, impeding a key step required for commitment to erythroid maturation

250 ent of the silver borate intermediate is the key step responsible for the stereochemical outcome of t

251 data analysis, called GridTools, into which key steps such as background correction and inference of

252 to the normalization of FFPE RNA-seq data, a key step that adjusts for unwanted biological and techni

253 lopentanone to a cyclic hydroxamic acid as a key step that allows facile installation of the embedded

254 rboxyl-terminal multisite phosphorylation as key step that drives acute mu-opioid receptor desensitiz

255 h-throughput assay that is able to measure a key step that is essential for successful completion of

256 In this Inaugural Article, I trace some key steps that have enabled the development of mass spec

257 erotrimeric G proteins by RTKs and chart the key steps that mediate such activation.

258 In this historical overview, I highlight key steps that the research into selective autophagy has

259 alculates transcripts per million (TPM) is a key step to compare multiple samples from different expe

260 the distinctive social effects of MDMA is a key step to developing the drug for psychiatric disorder

261 ically-active defects in semiconductors is a key step to harnessing the potential of solid-state qubi

262 easurable fluctuations, our method enables a key step to improve co-design of experiments and quantit

263 tween substrate binding and protonation is a key step to initiate transport.

264 subsequent coordination event, which was the key step to the successful multicomponent self-assembly.

265 ference of fitness landscapes of tumors is a key step to understanding evolutionary mechanisms drivin

266 chanisms of axis formation in amphioxus is a key step to understanding the evolution of chordate body

267 e a simple five-step protocol that addresses key steps to be taken and pitfalls to be avoided for the

268 promoting or inhibiting animal behaviors are key steps to understand how neural circuits control beha

269 a high coverage of antibodies on AuNPs is a key-step to build up a sensitive biosensor, but an ideal

270 ce to pathogens is achievable, and will be a key step toward increasing crop production in a sustaina

271 n these semiconductors not only represents a key step toward modern TMD-based spintronics, but also e

272 ate high-throughput proteomic analysis are a key step toward moving proteome investigations into clin

273 any EHR machine-learning platform, provide a key step toward precision medicine.

274 This preclinical study constitutes a key step toward preventing further global dissemination

275 This is a key step toward quantifying specific reactivities of sin

276 his position statement is that it provides a key step toward raising awareness of the importance of e

277 ms of transcriptional regulatory dynamics, a key step toward reaching a predictive understanding of d

278 Despite being a key step toward the evolution of complex organisms, the

279 tocompatibility complex class I (MHC I) is a key step toward the identification of relevant antigens

280 ion with different Pt sizes and represents a key step toward the rational design of new heterogeneous

281 A key step toward this goal is determining whether intrasp

282 le solar cells under intense conditions is a key step towards a reliable perovskite photovoltaic tech

283 Our open-source labels signify a key step towards a unified mouse brain atlas.

284 (hkl) single-crystal electrode surfaces is a key step towards addressing catalyst poisoning mechanism

285 iation has on a molecule's interactions is a key step towards connecting mechanistic characterization

286 g scheme for these molecules and represent a key step towards high-precision studies in these systems

287 that maintaining structural stability is the key step towards high-voltage operation of layered-catho

288 ificial atoms into phase-stable PICs marks a key step towards multiplexed quantum repeaters(7,8) and

289 Phosphorylation of PsK domain of MLKL is a key step towards oligomerization of 4HB domain that caus

290 ed tool to accurately determine prognosis, a key step towards personalized treatment for cancer patie

291 Establishing such a framework is a key step towards quantifying normative and pathological

292 The result demonstrates a key step towards the readout of many spin qubits in para

293 Here, we demonstrate a key step towards this vision, and generate entanglement

294 nsducer inside the living cochlea, providing key steps towards developing intracochlear acoustic sens

295 The key step was a palladium-catalyzed oxidative annulation

296 The key step was an addition of difluorocarbene (:CF(2)) to

297 The key step was an intramolecular [2 + 2]-photocyclization.

298 To better understand this key step, we performed a survey of the interactions betw

299 Key steps were a palladium-catalyzed C(sp3)X-C(sp3)ZnX N

300 dation and a double C(sp(3))-H activation as key steps, with the latter allowing the efficient simult