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1 comes chaotic following transition to a full keyhole.
2 with low enough power to avoid generating a keyhole.
3 minant mechanism controlling flow behind the keyhole.
5 Using synchrotron X-ray imaging we reveal keyhole and bubble behaviour, quantifying their formatio
6 liminating the balling and sparring effects, keyhole and cavity formation by attaining effective melt
8 y across several parameter sets by analysing keyhole and plume morphologies, and identify a previousl
9 Keyhole number, to predict aspect ratio of a keyhole and the morphological transition from stable at
10 amics with high-energy x-rays shows that (i) keyholes are present across the range of power and scann
11 ., lack of fusions, gas-entrapped pores, and keyholes, are quantified by nine parameters including ma
12 ll-defined threshold from conduction mode to keyhole based on laser power density; and (iii) the tran
14 p the rear-wall; and (iii) immediately after keyhole collapse, bubbles undergo rapid growth due to pr
16 to the rapid formation then collapse of deep keyhole depressions in the surface which traps inert shi
17 enomenon of vapor depressions (also known as keyholes) during laser melting of metals as practiced in
18 7 x 2.5-mm spatial resolution, 4 seconds per keyhole dynamic frame) was obtained over 90 seconds befo
20 keyhole porosity formation mechanisms, e.g., keyhole fluctuation, collapse and bubble growth and shri
21 wer-velocity conditions, causing fast radial keyhole fluctuations (2.5-10 kHz); (ii) transition regim
22 eams significantly reduce the propensity for keyhole formation across a broad scan parameter space.
24 curs when an unstable vapor depression zone (keyhole) forms because of excess laser energy input.
26 nsistently emphasised structures such as the keyhole in Fissurella volcano and the ridge tips in Lott
27 ver, excessive recoil pressure can produce a keyhole inside the melt pool, which is associated with g
28 g a transverse magnetic field suppresses the keyhole instability by driving a secondary thermoelectri
32 ctylus punctatus), trematode parasites for a keyhole limpet (Fissurella latimarginata), and pinnother
33 Here, the unmineralized teeth of the giant keyhole limpet (Megathura crenulata) are shown to attain
34 for 19 species of the genus Haliotis plus a keyhole limpet and a more distantly related gastropod, t
35 xed with 150 mug GM-CSF) or control (100 mug keyhole limpet haemocyanin) via monthly intradermal inje
38 then conjugated to immunocyanin monomers of keyhole limpet hemocyanin (IC(KLH)) to create the MCV IC
41 8) - when conjugated to the carrier protein, keyhole limpet hemocyanin (KLH) - to be capable of induc
42 B7RP-1-Fc stimulated the production of anti-keyhole limpet hemocyanin (KLH) Ab, increasing anti-KLH
43 ) followed by five subcutaneous boosts of Id/keyhole limpet hemocyanin (KLH) administered with adjuva
44 unoglobulin (Ig) idiotype (Id) conjugated to keyhole limpet hemocyanin (KLH) and administered with gr
45 This GM2 derivative was covalently linked to keyhole limpet hemocyanin (KLH) and monophosphoryl lipid
46 The DCs were pulsed with 2 foreign proteins, keyhole limpet hemocyanin (KLH) and tetanus toxoid (TT),
47 e to immunization with two conjugates, Tn(c)-keyhole limpet hemocyanin (KLH) and Tn(c)-palmitic acid
48 al, anti-idiotypic mAb MK2-23, conjugated to keyhole limpet hemocyanin (KLH) as a carrier and given w
49 ell as influenza matrix peptide (Flu-MP) and keyhole limpet hemocyanin (KLH) as control antigens.
51 ts immunogenicity, we bound thiolated MEP to keyhole limpet hemocyanin (KLH) by using succinimidyl-4-
52 hat antibodies generated to the glycoprotein keyhole limpet hemocyanin (KLH) can cross-link with reac
53 ssful conjugation of the glycopeptide to the keyhole limpet hemocyanin (KLH) carrier protein complete
54 nthesis and conjugated to maleimide-modified keyhole limpet hemocyanin (KLH) carrier protein through
55 constant regions plus GM-CSF, or linkage to keyhole limpet hemocyanin (KLH) carrier protein were inc
57 soluble Delta71-82 alphaS, human betaS, and keyhole limpet hemocyanin (KLH) control proteins induced
59 mor cell lysates and the immunogenic protein keyhole limpet hemocyanin (KLH) for 24 h and then combin
60 d, chemically synthesized, and conjugated to keyhole limpet hemocyanin (KLH) for examining its immuno
61 e C6 position (6OXY(Gly)(4)OH) conjugated to keyhole limpet hemocyanin (KLH) has shown early proof-of
63 n with 2,4,6-trinitrophenol (TNP)-conjugated keyhole limpet hemocyanin (KLH) in a specific pathogen-f
64 immunization with the cocaine immunogen GNC-keyhole limpet hemocyanin (KLH) in preventing cocaine se
65 ulsed with influenza matrix peptide (MP) and keyhole limpet hemocyanin (KLH) in two healthy subjects.
67 econd-generation cocaine immunoconjugate GND-keyhole limpet hemocyanin (KLH) or with the anti-cocaine
68 (MyVax), comprising Id chemically coupled to keyhole limpet hemocyanin (KLH) plus granulocyte macroph
69 rotein conjugated to the immunogenic protein keyhole limpet hemocyanin (KLH) protects mice from tumor
70 on of the PI3P hapten to maleimide-activated keyhole limpet hemocyanin (KLH) provided a PI3P immunoge
71 igenic challenge of the transgenic mice with keyhole limpet hemocyanin (KLH) resulted in a decrease i
72 in animal models of inflammation including a keyhole limpet hemocyanin (KLH) study and a collagen-ind
73 re, the compounds demonstrated efficacy in a Keyhole Limpet Hemocyanin (KLH) study in rats, where the
74 was further conjugated to ovalbumin (OVA) or keyhole limpet hemocyanin (KLH) to enhance immunogenicit
76 d to the immunogenic foreign carrier protein keyhole limpet hemocyanin (KLH) using glutaraldehyde has
77 efficacy by adding antimyeloma idiotype (Id)-keyhole limpet hemocyanin (KLH) vaccine to vaccine-speci
79 o the peptides and to peptides conjugated to keyhole limpet hemocyanin (KLH) were characterized by th
80 different linker methods, to protein carrier keyhole limpet hemocyanin (KLH) were studied in mice.
81 d with peptide mimetics of GXM conjugated to keyhole limpet hemocyanin (KLH) with glutaraldehyde deve
84 u-His-Gly) is conjugated to ovalbumin (OVA), keyhole limpet hemocyanin (KLH), and a bis-maleimide; KL
86 ponse against an exogenous, nonself antigen, keyhole limpet hemocyanin (KLH), by releasing IL-4 in th
87 er the addition of a foreign helper protein, keyhole limpet hemocyanin (KLH), can augment the efficac
88 were gavaged with a single dose of 20 mg of keyhole limpet hemocyanin (KLH), followed by s.c. immuni
89 he globo H antigen conjugated to the protein keyhole limpet hemocyanin (KLH), has been in clinical ev
90 followed 4-6 weeks later by DCs pulsed with keyhole limpet hemocyanin (KLH), HLA-A*0201-positive res
91 in the primary response to PC conjugated to keyhole limpet hemocyanin (KLH), T15 Id(+) Abs constitut
92 nti-idiotypic mAb immunization protocol (mAb-keyhole limpet hemocyanin (KLH)-Calmette-Guerin bacillus
94 c mice were cocultured with HDK-1 T cells (a keyhole limpet hemocyanin (KLH)-specific CD4+ Th1 clone)
95 MoPn), a nonprotective clone (N-MoPn), and a keyhole limpet hemocyanin (KLH)-specific cell line (KLH-
102 ed with recombinant HPV16/18 E7 antigens and keyhole limpet hemocyanin (KLH; an immunological tracer
103 ith 4-hydroxy-3-nitrophenyl(5) conjugated to keyhole limpet hemocyanin (NP(5)- KLH) or infected with
104 e response to 4-hydroxy-3-nitrophenyl acetyl-keyhole limpet hemocyanin (NP-KLH) and NP-OVA develops w
105 hydroxy-3-nitrophenyl acetyl (NP)-conjugated keyhole limpet hemocyanin (NP-KLH) or ovalbumin(323-337)
108 ubjected to disease-inducing (TNP-conjugated keyhole limpet hemocyanin [TNP-KLH]) and disease-inhibit
110 immunized with nitrophenol hapten-conjugated keyhole limpet hemocyanin adsorbed to Imject aluminum hy
111 rvivors mounted a substantial Ab response to keyhole limpet hemocyanin after completion of anti-CD40L
114 ar versus vaccination with GM2 conjugated to keyhole limpet hemocyanin and administered with QS-21 (G
115 latimarginata hemocyanin in comparison with keyhole limpet hemocyanin and C. concholepas hemocyanin,
116 G antibody responses against protein antigen keyhole limpet hemocyanin and carbohydrate antigen sTn,
118 gainst 3-hydroxykynurenine (3OHKYN)-modified keyhole limpet hemocyanin and characterized it using 3OH
120 ne consisting of tumor Ig protein coupled to keyhole limpet hemocyanin and emulsified in an immunolog
122 ations with cytokine-matured DCs loaded with keyhole limpet hemocyanin and MHC-I alone or MHC-I/II-re
123 ation to two different immunogenic carriers, keyhole limpet hemocyanin and N-alpha-palmitoyl-S-[2,3-b
124 sed humoral responses to the T-dependent Ags keyhole limpet hemocyanin and OVA, as well as reduced Ag
125 so inhibits production of antibodies against keyhole limpet hemocyanin and Pneumovax in mice, indicat
127 impet hemocyanin or trinitrophenylated (TNP) keyhole limpet hemocyanin and the type 2 T-independent A
128 ne, or from the hybridoma, was conjugated to keyhole limpet hemocyanin and used to immunize Balb/c mi
129 domain of VlsE was conjugated to the carrier keyhole limpet hemocyanin and used to immunize mice.
130 sorbent assay and immunoblots using anti-AGE-keyhole limpet hemocyanin antibody, aminoguanidine inhib
131 al responses of L-selectin-deficient mice to keyhole limpet hemocyanin are indistinguishable from wil
132 Abs were induced after immunization with PC-keyhole limpet hemocyanin but at significantly lower lev
133 8+ alloreactive CTL, and development of anti-keyhole limpet hemocyanin CD4+ T cells, rejection of all
134 cious vaccine, MH6, was then contrasted with keyhole limpet hemocyanin conjugate vaccine in a subsequ
138 nd immunogenicity of three synthetic globo H-keyhole limpet hemocyanin conjugates plus the immunologi
140 LS (SagA) propeptide [SLS(10-30)] coupled to keyhole limpet hemocyanin evoked antibodies in rabbits t
141 ation of naive mice with 3H1 conjugated with keyhole limpet hemocyanin Freund's adjuvant induced humo
143 ng 2,4,6-trinitrophenyl hapten conjugated to keyhole limpet hemocyanin immunization and nephritis ind
144 2,4,6-Trinitrophenyl hapten conjugated to keyhole limpet hemocyanin immunization resulted in highe
145 40L mRNA, antigen-specific IgG1 responses to keyhole limpet hemocyanin immunization, regulated CD4(+)
147 Ficoll and in 4-hydroxy-3-nitrophenyl acetyl-keyhole limpet hemocyanin immunized animals; recall resp
148 timulate a T helper 2 response (ovalbumin or keyhole limpet hemocyanin in alum) and is only seen with
150 , 1,000-, or 100,000-mug doses of intranasal keyhole limpet hemocyanin in conjunction with adjuvant i
153 concurrent with a secondary Th2 response to keyhole limpet hemocyanin or A. fumagatus extract, or by
154 nd that loading immature DCs with the neoAgs keyhole limpet hemocyanin or human immunodeficiency viru
155 concurrent, secondary Th2 lung responses to keyhole limpet hemocyanin or primary responses to Nippos
156 -dependent (TD) Ags fluorescein-labeled (FL) keyhole limpet hemocyanin or trinitrophenylated (TNP) ke
157 lls from normal and B cell-deficient mice to keyhole limpet hemocyanin over 6 mo and observed diminis
159 nd we have prepared a conjugate vaccine (GD2-keyhole limpet hemocyanin plus immunological adjuvant QS
160 ed from the original tumor, including (1) Id-keyhole limpet hemocyanin protein, (2) Id single-chain v
161 g rabbits with an F(2)Pab peptide coupled to keyhole limpet hemocyanin recognized a p53(1-39) peptide
162 Furthermore, CLEC12A-mediated delivery of keyhole limpet hemocyanin resulted in enhanced prolifera
163 ccinated with peptide 184- 198 conjugated to keyhole limpet hemocyanin showed significant pulmonary e
166 munogenicity of coupling the glycopeptide to keyhole limpet hemocyanin was examined; although both Ig
167 specific Abs following immunization with DNP-keyhole limpet hemocyanin was significantly decreased fo
168 of FDC networks, the primary Ab response to keyhole limpet hemocyanin was unaltered over a 20-day pe
169 responses to 2,4,6-trinitrophenyl-conjugated keyhole limpet hemocyanin were measured by ELISA, and pr
170 roduction of high-affinity antibodies to TNP-keyhole limpet hemocyanin were severely impaired, even a
171 ing 3 mg/kg iscalimab, antibody responses to keyhole limpet hemocyanin were transiently suppressed.
172 hesion to CR3 counterligands (fibrinogen and keyhole limpet hemocyanin) by 50%, but did not affect ad
173 (bacteriophage phiX 174 and nuclear protein-keyhole limpet hemocyanin) characterized by a reduction
175 on of humoral immunity to model Ags (OVA and keyhole limpet hemocyanin), affecting all major T-depend
176 ella latimarginata, and Megathura crenulata (keyhole limpet hemocyanin), on cultures of peritoneal ma
178 ed pulp by day 3 after immunization with Ars-keyhole limpet hemocyanin, (KLH) and at day 6, large clu
179 ccharide has been synthesized, conjugated to keyhole limpet hemocyanin, and administered with the imm
180 immunized with caffeine covalently linked to keyhole limpet hemocyanin, and recombinant antibody tech
181 These peptides were synthesized, coupled to keyhole limpet hemocyanin, and used to produce rabbit an
182 o the model Ag 4-hydroxy-3-nitrophenylacetyl-keyhole limpet hemocyanin, but GrB-deficient mice produc
183 es isolated from plasma of mice immunized to keyhole limpet hemocyanin, but not from naive or OVA-imm
184 result, when immunized with nitrophenylated-keyhole limpet hemocyanin, Dbc1(-/-) mice produce signif
187 the Ab response to the T cell-dependent Ag, keyhole limpet hemocyanin, in the PDE7A(-/-) mice was fo
189 , IgM response to Pneumovax, IgG response to keyhole limpet hemocyanin, or cytokine response to LPS).
190 T-dependent Ag, phosphocholine conjugated to keyhole limpet hemocyanin, ppc1-5 NAA B cells mounted a
191 pulsing DCs with the foreign helper protein, keyhole limpet hemocyanin, prior to intratumoral deliver
192 Following vaccination with the TCR linked to keyhole limpet hemocyanin, specific anti-TCR humoral res
194 d primary response to the T-dependent Ag DNP-keyhole limpet hemocyanin, the Tg mice exhibited severel
195 mary allergic sensitization to a neoantigen, keyhole limpet hemocyanin, using a unique model of human
197 ing two recombinant filarial protein Ags and keyhole limpet hemocyanin, we sensitized T cells from un
198 decarboxylase (GAD), but not the control Ag keyhole limpet hemocyanin, were eliminated in NODJg mu(n
199 ystemically administered soluble protein Ag, keyhole limpet hemocyanin, were enhanced when mice were
200 man apoA-I, with or without conjugation with keyhole limpet hemocyanin, were fused with P3/NS1/1-Ag4-
201 of B7-H1Ig fusion protein, however, enhances keyhole limpet hemocyanin- specific T-cell proliferation
202 ient in Mac-1 were defective in adherence to keyhole limpet hemocyanin-coated glass, iC3b-mediated ph
203 7BL/6 mice were immunized with a cocktail of keyhole limpet hemocyanin-conjugated peptides correspond
205 nced proliferation and cytokine secretion by keyhole limpet hemocyanin-experienced CD4(+) T cells.
206 onor-specific Th2 cells, lymphoid cells from keyhole limpet hemocyanin-immune mice bearing healthy co
207 MR-1 in various preclinical models, such as keyhole limpet hemocyanin-induced Ab responses, alloanti
208 Guinea pigs immunized intranasally with a keyhole limpet hemocyanin-linked peptide, corresponding
209 VA-immunized mice, were able to suppress the keyhole limpet hemocyanin-specific delayed-type hypersen
210 f concanavalin A-stimulated spleen cells nor keyhole limpet hemocyanin-specific proliferation of sple
211 tion with LPS or upon 6-h coculture with the keyhole limpet hemocyanin-specific Th1 clone HDK-1 in th
212 3 to 24 h of incubation with HDK-1 T cells (keyhole limpet hemocyanin-specific TH1 clone) or with 5S
213 mice that were reconstituted with a clone of keyhole limpet hemocyanin-specific Th2 cells and trinitr
236 strong suppression of IgE in response to DNP-keyhole limpet hemocyanin/alum and Nippostrongylus brasi
237 er, pulsing MoDC with conjugates of primary (keyhole limpet hemocyanin; KLH) and recall (Bet v 1) Ags
238 nd linked GH to a carrier protein, including keyhole limpet hemocyanion, diphtheria toxoid cross-reac
239 ith the phase III clinical trial vaccine, GH-keyhole limpet hemocyanion/QS21, the GH-DT/C34 vaccine e
241 st as much as the more obvious outgroup, the keyhole limpet, an observation common to other DNA seque
243 Within the three cell type cluster complex, keyhole limpit hemocyanin or tetanus toxoid-reactive Th
247 y of the full-Fourier image, whereas the 50% keyhole method degraded the spatial resolution by a fact
248 usion zones, the direct visualization of the keyhole morphology and dynamics with high-energy x-rays
252 sics simulations, we discovered two types of keyhole oscillation in laser powder bed fusion of Ti-6Al
254 mong clamp proteins and exhibits a "key in a keyhole" pattern where a bulky aromatic residue from one
256 manufacturing (AM), process defects such as keyhole pores are difficult to anticipate, affecting the
257 he findings support the hypotheses that: (i) keyhole porosity can initiate not only in unstable, but
259 ped an approach for detecting the stochastic keyhole porosity generation events with submillisecond t
262 pattern was used to reduce the formation of keyhole porosity, which was caused by excessive vaporiza
265 only in unstable, but also in the transition keyhole regimes created by high laser power-velocity con
267 d an intermediate characteristic "triangular keyhole" shape in the 3D deformations of the hindgut.
268 Catheter placement via the supraorbital keyhole (SOK) for removing spontaneous intracerebral hem
270 re, we discover inherent correlation between keyhole stability and porosity formation in metal 3D pri
271 entify simple yet universal scaling laws for keyhole stability and porosity in metal 3D printing.
272 cervical hysterectomy involves laparoscopic (keyhole) surgery to remove the upper part of the uterus
273 aker technique had less recurrences than the keyhole technique (OR 2.3, 95% CI 1.2-4.6; P = 0.016).
274 iled gradient-recalled-echo imaging with the keyhole technique during the administration of 0.1 mmol/
276 t vital driving force for the pores near the keyhole tip to move away from the keyhole and become tra
278 terize the evolution of the melt pool shape, keyhole, vapor plume, and thermal evolution in Ti-6Al-4V
279 e flow vortex-induced protrusion on the rear keyhole wall is crucial in initiating keyhole instabilit
280 ith deep and narrow vapor depressions called keyholes, which occur under high-power, low-scan speed l
281 leoside is located in the narrow part of the keyhole, while the sugar occupies the wider opening.