ライフサイエンスコーパス: keyhole-limpet hemocyanin

1 n with a thymus-dependent Ag, phosphocholine-keyhole limpet hemocyanin.

2 single ascending dose groups challenged with keyhole limpet hemocyanin.

3 following immunization of male SJL mice with keyhole limpet hemocyanin.

4 eptides was increased by conjugating them to keyhole limpet hemocyanin.

5 uptake using FITC-labeled tetanus, OVA, and keyhole limpet hemocyanin.

6 tion, including host-restricted responses to keyhole limpet hemocyanin.

7 cell response against 2,4,6 trinitro-phenyl-keyhole limpet hemocyanin.

8 an isotype-matched control Ig, conjugated to keyhole limpet hemocyanin.

9 otetraose, or to oligosaccharides present on keyhole limpet hemocyanin.

10 njugate of sLe(a) with the benchmark carrier keyhole limpet hemocyanin.

11 monas exotoxin A, as well as to the model Ag keyhole limpet hemocyanin.

12 zation with the T cell-dependent (TD) Ag DNP-keyhole limpet hemocyanin.

13 ice were similar after immunization with DNP-keyhole limpet hemocyanin.

14 coll and to the T cell-dependent antigen TNP-keyhole limpet hemocyanin.

15 accharides were coupled with carrier protein keyhole limpet hemocyanin.

16 s immunized with UO(2)(2+)-DCP conjugated to keyhole limpet hemocyanin.

17 ing of lymphoma immunoglobulin conjugated to keyhole limpet hemocyanin.

18 n a mammalian cell and chemically coupled to keyhole limpet hemocyanin.

19 Cys-27-NH2 as a hapten, conjugated to BSA or keyhole limpet hemocyanin.

20 that had been immunized with trinitrophenyl-keyhole limpet hemocyanin.

21 bits (27- to 81-fold) after conjugation with keyhole limpet hemocyanin.

22 Inhibition of anti-keyhole limpet hemocyanin Ab response was dose-dependent

23 immunized with nitrophenol hapten-conjugated keyhole limpet hemocyanin adsorbed to Imject aluminum hy

24 on of humoral immunity to model Ags (OVA and keyhole limpet hemocyanin), affecting all major T-depend

25 rvivors mounted a substantial Ab response to keyhole limpet hemocyanin after completion of anti-CD40L

26 Moreover, mDCs(ICOS) pulsed with the keyhole limpet hemocyanin Ag during the maturation phase

27 es to alloantigen and secondary responses to keyhole limpet hemocyanin Ag.

28 strong suppression of IgE in response to DNP-keyhole limpet hemocyanin/alum and Nippostrongylus brasi

29 ar versus vaccination with GM2 conjugated to keyhole limpet hemocyanin and administered with QS-21 (G

30 latimarginata hemocyanin in comparison with keyhole limpet hemocyanin and C. concholepas hemocyanin,

31 G antibody responses against protein antigen keyhole limpet hemocyanin and carbohydrate antigen sTn,

32 CD4+ T cell sensitization to keyhole limpet hemocyanin and CD8+ T cell sensitization

33 gainst 3-hydroxykynurenine (3OHKYN)-modified keyhole limpet hemocyanin and characterized it using 3OH

34 he immune responses to two soluble proteins, keyhole limpet hemocyanin and chicken egg albumin.

35 ne consisting of tumor Ig protein coupled to keyhole limpet hemocyanin and emulsified in an immunolog

36 Th2 immune deviation induced with keyhole limpet hemocyanin and IFA did not affect corneal

37 ations with cytokine-matured DCs loaded with keyhole limpet hemocyanin and MHC-I alone or MHC-I/II-re

38 ation to two different immunogenic carriers, keyhole limpet hemocyanin and N-alpha-palmitoyl-S-[2,3-b

39 sed humoral responses to the T-dependent Ags keyhole limpet hemocyanin and OVA, as well as reduced Ag

40 so inhibits production of antibodies against keyhole limpet hemocyanin and Pneumovax in mice, indicat

41 In response to trinitrophenol (TNP)-keyhole limpet hemocyanin and tetanus/diphtheria vaccine

42 impet hemocyanin or trinitrophenylated (TNP) keyhole limpet hemocyanin and the type 2 T-independent A

43 ne, or from the hybridoma, was conjugated to keyhole limpet hemocyanin and used to immunize Balb/c mi

44 domain of VlsE was conjugated to the carrier keyhole limpet hemocyanin and used to immunize mice.

45 ccharide has been synthesized, conjugated to keyhole limpet hemocyanin, and administered with the imm

46 immunized with caffeine covalently linked to keyhole limpet hemocyanin, and recombinant antibody tech

47 These peptides were synthesized, coupled to keyhole limpet hemocyanin, and used to produce rabbit an

48 sorbent assay and immunoblots using anti-AGE-keyhole limpet hemocyanin antibody, aminoguanidine inhib

49 al responses of L-selectin-deficient mice to keyhole limpet hemocyanin are indistinguishable from wil

50 Abs were induced after immunization with PC-keyhole limpet hemocyanin but at significantly lower lev

51 o the model Ag 4-hydroxy-3-nitrophenylacetyl-keyhole limpet hemocyanin, but GrB-deficient mice produc

52 es isolated from plasma of mice immunized to keyhole limpet hemocyanin, but not from naive or OVA-imm

53 hesion to CR3 counterligands (fibrinogen and keyhole limpet hemocyanin) by 50%, but did not affect ad

54 8+ alloreactive CTL, and development of anti-keyhole limpet hemocyanin CD4+ T cells, rejection of all

55 (bacteriophage phiX 174 and nuclear protein-keyhole limpet hemocyanin) characterized by a reduction

56 ient in Mac-1 were defective in adherence to keyhole limpet hemocyanin-coated glass, iC3b-mediated ph

57 cious vaccine, MH6, was then contrasted with keyhole limpet hemocyanin conjugate vaccine in a subsequ

58 to mice immunized with the native 38C13 IgM-keyhole limpet hemocyanin conjugate vaccine.

59 vaccines (MH2[R], MH6, and MH7) or a control keyhole limpet hemocyanin conjugate vaccine.

60 7BL/6 mice were immunized with a cocktail of keyhole limpet hemocyanin-conjugated peptides correspond

61 Mice vaccinated with the CD20 peptide keyhole limpet hemocyanin conjugates had a 25% decrease

62 nd immunogenicity of three synthetic globo H-keyhole limpet hemocyanin conjugates plus the immunologi

63 result, when immunized with nitrophenylated-keyhole limpet hemocyanin, Dbc1(-/-) mice produce signif

64 When immunized with trinitrophenyl-keyhole limpet hemocyanin, dbh-/- mice produced less Th1

65 Mice immunized with PA1 conjugated to keyhole limpet hemocyanin developed high anti-peptide (1

66 -dependent antigen, 2,4-dinitrophenyl hapten-keyhole limpet hemocyanin (DNP(23)-KLH).

67 sotypes distinct from those generated by the keyhole limpet hemocyanin-epitope conjugates.

68 LS (SagA) propeptide [SLS(10-30)] coupled to keyhole limpet hemocyanin evoked antibodies in rabbits t

69 nced proliferation and cytokine secretion by keyhole limpet hemocyanin-experienced CD4(+) T cells.

70 ation of naive mice with 3H1 conjugated with keyhole limpet hemocyanin Freund's adjuvant induced humo

71 Immunization with DNP-keyhole limpet hemocyanin, heat-killed Brucella abortus,

72 then conjugated to immunocyanin monomers of keyhole limpet hemocyanin (IC(KLH)) to create the MCV IC

73 h 8 injections using the standard therapy of keyhole limpet hemocyanin Id + GM-CSF.

74 ing of Id to the immunogenic carrier protein keyhole limpet hemocyanin (Id-KLH).

75 onor-specific Th2 cells, lymphoid cells from keyhole limpet hemocyanin-immune mice bearing healthy co

76 ng 2,4,6-trinitrophenyl hapten conjugated to keyhole limpet hemocyanin immunization and nephritis ind

77 2,4,6-Trinitrophenyl hapten conjugated to keyhole limpet hemocyanin immunization resulted in highe

78 40L mRNA, antigen-specific IgG1 responses to keyhole limpet hemocyanin immunization, regulated CD4(+)

79 ncreased numbers of Th1 cells in response to keyhole limpet hemocyanin immunization.

80 Ficoll and in 4-hydroxy-3-nitrophenyl acetyl-keyhole limpet hemocyanin immunized animals; recall resp

81 timulate a T helper 2 response (ovalbumin or keyhole limpet hemocyanin in alum) and is only seen with

82 After immunization with OVA or keyhole limpet hemocyanin in CFA, NK cell-deficient (NK-

83 , 1,000-, or 100,000-mug doses of intranasal keyhole limpet hemocyanin in conjunction with adjuvant i

84 the Ab response to the T cell-dependent Ag, keyhole limpet hemocyanin, in the PDE7A(-/-) mice was fo

85 MR-1 in various preclinical models, such as keyhole limpet hemocyanin-induced Ab responses, alloanti

86 TCR Id protein conjugated to keyhole limpet hemocyanin (KLH) (TCR Id:KLH) and injecte

87 8) - when conjugated to the carrier protein, keyhole limpet hemocyanin (KLH) - to be capable of induc

88 B7RP-1-Fc stimulated the production of anti-keyhole limpet hemocyanin (KLH) Ab, increasing anti-KLH

89 ) followed by five subcutaneous boosts of Id/keyhole limpet hemocyanin (KLH) administered with adjuva

90 unoglobulin (Ig) idiotype (Id) conjugated to keyhole limpet hemocyanin (KLH) and administered with gr

91 This GM2 derivative was covalently linked to keyhole limpet hemocyanin (KLH) and monophosphoryl lipid

92 The DCs were pulsed with 2 foreign proteins, keyhole limpet hemocyanin (KLH) and tetanus toxoid (TT),

93 e to immunization with two conjugates, Tn(c)-keyhole limpet hemocyanin (KLH) and Tn(c)-palmitic acid

94 al, anti-idiotypic mAb MK2-23, conjugated to keyhole limpet hemocyanin (KLH) as a carrier and given w

95 ell as influenza matrix peptide (Flu-MP) and keyhole limpet hemocyanin (KLH) as control antigens.

96 Subjects were fed keyhole limpet hemocyanin (KLH) before subcutaneous immu

97 ts immunogenicity, we bound thiolated MEP to keyhole limpet hemocyanin (KLH) by using succinimidyl-4-

98 hat antibodies generated to the glycoprotein keyhole limpet hemocyanin (KLH) can cross-link with reac

99 ssful conjugation of the glycopeptide to the keyhole limpet hemocyanin (KLH) carrier protein complete

100 nthesis and conjugated to maleimide-modified keyhole limpet hemocyanin (KLH) carrier protein through

101 constant regions plus GM-CSF, or linkage to keyhole limpet hemocyanin (KLH) carrier protein were inc

102 To solve this problem, the keyhole limpet hemocyanin (KLH) conjugates of a series o

103 soluble Delta71-82 alphaS, human betaS, and keyhole limpet hemocyanin (KLH) control proteins induced

104 Volunteers were immunized with keyhole limpet hemocyanin (KLH) first orally and then pa

105 mor cell lysates and the immunogenic protein keyhole limpet hemocyanin (KLH) for 24 h and then combin

106 d, chemically synthesized, and conjugated to keyhole limpet hemocyanin (KLH) for examining its immuno

107 e C6 position (6OXY(Gly)(4)OH) conjugated to keyhole limpet hemocyanin (KLH) has shown early proof-of

108 ective antitumor immunity induced by s.c. Id-keyhole limpet hemocyanin (KLH) immunization.

109 n with 2,4,6-trinitrophenol (TNP)-conjugated keyhole limpet hemocyanin (KLH) in a specific pathogen-f

110 immunization with the cocaine immunogen GNC-keyhole limpet hemocyanin (KLH) in preventing cocaine se

111 ulsed with influenza matrix peptide (MP) and keyhole limpet hemocyanin (KLH) in two healthy subjects.

112 Mice immunized with the Ag keyhole limpet hemocyanin (KLH) mixed with HKL generated

113 econd-generation cocaine immunoconjugate GND-keyhole limpet hemocyanin (KLH) or with the anti-cocaine

114 (MyVax), comprising Id chemically coupled to keyhole limpet hemocyanin (KLH) plus granulocyte macroph

115 rotein conjugated to the immunogenic protein keyhole limpet hemocyanin (KLH) protects mice from tumor

116 on of the PI3P hapten to maleimide-activated keyhole limpet hemocyanin (KLH) provided a PI3P immunoge

117 igenic challenge of the transgenic mice with keyhole limpet hemocyanin (KLH) resulted in a decrease i

118 in animal models of inflammation including a keyhole limpet hemocyanin (KLH) study and a collagen-ind

119 re, the compounds demonstrated efficacy in a Keyhole Limpet Hemocyanin (KLH) study in rats, where the

120 was further conjugated to ovalbumin (OVA) or keyhole limpet hemocyanin (KLH) to enhance immunogenicit

121 was manufactured and covalently linked with keyhole limpet hemocyanin (KLH) to generate Id/KLH.

122 d to the immunogenic foreign carrier protein keyhole limpet hemocyanin (KLH) using glutaraldehyde has

123 efficacy by adding antimyeloma idiotype (Id)-keyhole limpet hemocyanin (KLH) vaccine to vaccine-speci

124 Keyhole limpet hemocyanin (KLH) was beneficial in earlie

125 o the peptides and to peptides conjugated to keyhole limpet hemocyanin (KLH) were characterized by th

126 different linker methods, to protein carrier keyhole limpet hemocyanin (KLH) were studied in mice.

127 d with peptide mimetics of GXM conjugated to keyhole limpet hemocyanin (KLH) with glutaraldehyde deve

128 T-independent (TNP-LPS) or T-dependent (TNP-keyhole limpet hemocyanin (KLH)) Ag.

129 Following challenge with TNP-keyhole limpet hemocyanin (KLH), Ab production in these

130 u-His-Gly) is conjugated to ovalbumin (OVA), keyhole limpet hemocyanin (KLH), and a bis-maleimide; KL

131 Rats were immunized with keyhole limpet hemocyanin (KLH), and blood samples were

132 ponse against an exogenous, nonself antigen, keyhole limpet hemocyanin (KLH), by releasing IL-4 in th

133 er the addition of a foreign helper protein, keyhole limpet hemocyanin (KLH), can augment the efficac

134 were gavaged with a single dose of 20 mg of keyhole limpet hemocyanin (KLH), followed by s.c. immuni

135 he globo H antigen conjugated to the protein keyhole limpet hemocyanin (KLH), has been in clinical ev

136 followed 4-6 weeks later by DCs pulsed with keyhole limpet hemocyanin (KLH), HLA-A*0201-positive res

137 in the primary response to PC conjugated to keyhole limpet hemocyanin (KLH), T15 Id(+) Abs constitut

138 nti-idiotypic mAb immunization protocol (mAb-keyhole limpet hemocyanin (KLH)-Calmette-Guerin bacillus

139 However, keyhole limpet hemocyanin (KLH)-priming of IFN-gko mice

140 c mice were cocultured with HDK-1 T cells (a keyhole limpet hemocyanin (KLH)-specific CD4+ Th1 clone)

141 MoPn), a nonprotective clone (N-MoPn), and a keyhole limpet hemocyanin (KLH)-specific cell line (KLH-

142 ere immunized with ovalbumin peptide or with keyhole limpet hemocyanin (KLH).

143 usly with ovalbumin and a secondary antigen, keyhole limpet hemocyanin (KLH).

144 rotein conjugate, 2,4,6-trinitrophenyl (TNP)-keyhole limpet hemocyanin (KLH).

145 in mice 24 to 48 h before immunization with keyhole limpet hemocyanin (KLH).

146 c IgY production following immunization with keyhole limpet hemocyanin (KLH).

147 b, 2C10, or vehicle before immunization with keyhole limpet hemocyanin (KLH).

148 ed with recombinant HPV16/18 E7 antigens and keyhole limpet hemocyanin (KLH; an immunological tracer

149 ed pulp by day 3 after immunization with Ars-keyhole limpet hemocyanin, (KLH) and at day 6, large clu

150 er, pulsing MoDC with conjugates of primary (keyhole limpet hemocyanin; KLH) and recall (Bet v 1) Ags

151 Guinea pigs immunized intranasally with a keyhole limpet hemocyanin-linked peptide, corresponding

152 Efficacy experiments in a keyhole limpet hemocyanin model in rats demonstrated tha

153 Antibodies were raised by using keyhole limpet hemocyanin modified in vitro by 4-hydroxy

154 Imaging of DNA, keyhole limpet hemocyanin, mouse monoclonal IgG, and glu

155 ith 4-hydroxy-3-nitrophenyl(5) conjugated to keyhole limpet hemocyanin (NP(5)- KLH) or infected with

156 e response to 4-hydroxy-3-nitrophenyl acetyl-keyhole limpet hemocyanin (NP-KLH) and NP-OVA develops w

157 hydroxy-3-nitrophenyl acetyl (NP)-conjugated keyhole limpet hemocyanin (NP-KLH) or ovalbumin(323-337)

158 ella latimarginata, and Megathura crenulata (keyhole limpet hemocyanin), on cultures of peritoneal ma

159 concurrent with a secondary Th2 response to keyhole limpet hemocyanin or A. fumagatus extract, or by

160 nd that loading immature DCs with the neoAgs keyhole limpet hemocyanin or human immunodeficiency viru

161 concurrent, secondary Th2 lung responses to keyhole limpet hemocyanin or primary responses to Nippos

162 -dependent (TD) Ags fluorescein-labeled (FL) keyhole limpet hemocyanin or trinitrophenylated (TNP) ke

163 , IgM response to Pneumovax, IgG response to keyhole limpet hemocyanin, or cytokine response to LPS).

164 lls from normal and B cell-deficient mice to keyhole limpet hemocyanin over 6 mo and observed diminis

165 ed toward Th2 responses by immunization with keyhole limpet hemocyanin plus IFA.

166 nd we have prepared a conjugate vaccine (GD2-keyhole limpet hemocyanin plus immunological adjuvant QS

167 T-dependent Ag, phosphocholine conjugated to keyhole limpet hemocyanin, ppc1-5 NAA B cells mounted a

168 pulsing DCs with the foreign helper protein, keyhole limpet hemocyanin, prior to intratumoral deliver

169 ed from the original tumor, including (1) Id-keyhole limpet hemocyanin protein, (2) Id single-chain v

170 g rabbits with an F(2)Pab peptide coupled to keyhole limpet hemocyanin recognized a p53(1-39) peptide

171 Furthermore, CLEC12A-mediated delivery of keyhole limpet hemocyanin resulted in enhanced prolifera

172 ccinated with peptide 184- 198 conjugated to keyhole limpet hemocyanin showed significant pulmonary e

173 Ag (keyhole limpet hemocyanin)-specific Th1/Th2 responses of

174 Following vaccination with the TCR linked to keyhole limpet hemocyanin, specific anti-TCR humoral res

175 After immunization with trinitrophenyl-keyhole limpet hemocyanin, specific ASC could be isolate

176 of B7-H1Ig fusion protein, however, enhances keyhole limpet hemocyanin- specific T-cell proliferation

177 VA-immunized mice, were able to suppress the keyhole limpet hemocyanin-specific delayed-type hypersen

178 f concanavalin A-stimulated spleen cells nor keyhole limpet hemocyanin-specific proliferation of sple

179 tion with LPS or upon 6-h coculture with the keyhole limpet hemocyanin-specific Th1 clone HDK-1 in th

180 3 to 24 h of incubation with HDK-1 T cells (keyhole limpet hemocyanin-specific TH1 clone) or with 5S

181 mice that were reconstituted with a clone of keyhole limpet hemocyanin-specific Th2 cells and trinitr

182 The sera raised against keyhole limpet hemocyanin-SV1 hapten, showed binding val

183 d primary response to the T-dependent Ag DNP-keyhole limpet hemocyanin, the Tg mice exhibited severel

184 se in mice primed with 2,4, 6-trinitrophenyl-keyhole limpet hemocyanin (TNP-KLH).

185 ubjected to disease-inducing (TNP-conjugated keyhole limpet hemocyanin [TNP-KLH]) and disease-inhibit

186 Intratumoral VVHY, VVGMCSF, and keyhole limpet hemocyanin (to produce CD4 help) generate

187 mary allergic sensitization to a neoantigen, keyhole limpet hemocyanin, using a unique model of human

188 yl) form of ghrelin as compared with Ghr2 or keyhole limpet hemocyanin vaccinated controls.

189 y, delayed-type hypersensitivity response to keyhole limpet hemocyanin was diminished.

190 munogenicity of coupling the glycopeptide to keyhole limpet hemocyanin was examined; although both Ig

191 specific Abs following immunization with DNP-keyhole limpet hemocyanin was significantly decreased fo

192 of FDC networks, the primary Ab response to keyhole limpet hemocyanin was unaltered over a 20-day pe

193 ndent neoantigens, bacteriophage phiX174 and keyhole limpet hemocyanin, was also evaluated.

194 ing two recombinant filarial protein Ags and keyhole limpet hemocyanin, we sensitized T cells from un

195 responses to 2,4,6-trinitrophenyl-conjugated keyhole limpet hemocyanin were measured by ELISA, and pr

196 roduction of high-affinity antibodies to TNP-keyhole limpet hemocyanin were severely impaired, even a

197 ing 3 mg/kg iscalimab, antibody responses to keyhole limpet hemocyanin were transiently suppressed.

198 nd proliferative response to recall antigen (keyhole limpet hemocyanin) were normal.

199 decarboxylase (GAD), but not the control Ag keyhole limpet hemocyanin, were eliminated in NODJg mu(n

200 ystemically administered soluble protein Ag, keyhole limpet hemocyanin, were enhanced when mice were

201 man apoA-I, with or without conjugation with keyhole limpet hemocyanin, were fused with P3/NS1/1-Ag4-