ライフサイエンスコーパス: killing

1 ingococcal resistance to complement-mediated killing.

2 trafficking to the tumor and mediating cell killing.

3 al essential steps in PGRP-induced bacterial killing.

4 tially explaining one mechanism of bacterial killing.

5 resistance to neutrophil-mediated bacterial killing.

6 migration toward tumor cells, and tumor cell killing.

7 ed SMAP component that contributed to target killing.

8 rtially restored cell couple maintenance and killing.

9 cells and macrophages, to induce tumor cell killing.

10 pharmacokinetics and radiation-induced cell killing.

11 sistance of reservoir-harboring cells to CTL killing.

12 slink tumor and T-cells to induce tumor cell killing.

13 le production and shielding from nonspecific killing.

14 ation-induced bacterial permeabilization and killing.

15 pd1 is required for resistance to neutrophil killing.

16 tic granule contents during NK cell-mediated killing.

17 ession in primary T cells, led to tumor cell killing.

18 nce, and tissue penetration to maximize cell killing.

19 iting HER2 overexpression for improved tumor killing.

20 the meningococcal surface and meningococcal killing.

21 apacity but not the specificity of cytotoxic killing.

22 sostaphin degradation and host cell-mediated killing.

23 r survival and protection against neutrophil killing.

24 istinct role in amebic trogocytosis and cell killing.

25 ased TIL locomotion, and impaired tumor cell killing.

26 anisms to escape opsonization and complement killing.

27 ogocytosis and phagocytosis, as well as cell killing.

28 n the mucosal barrier and invasive bacterial killing.

29 ance NK cell activation and NK cell-mediated killing.

30 CytoD was able to abrogate C. albicans killing.

31 produced a ferumoxytol-dose dependent tumor killing.

32 bilities of proliferation and tumor-specific killing.

33 ntibodies to PD-1 or PD-L1, to enhance tumor killing.

34 bled higher tissue penetration and more cell killing.

35 facilitate spirochete evasion of complement killing.

36 WT but not REG3gamma-deficient IEC bacterial killing.

37 cytotoxicity has not been linked to parasite killing.

38 flammatory cytokines, leading to target cell killing.

39 ersistent natural killer (NK) cell cytolytic killing.

40 oduction and high resistance to PGRP-induced killing.

41 re also observed for different cytokines and killing.

42 serve as reagents for bacterial imaging and killing.

43 processes such as bacterial phagocytosis and killing.

44 vectors encoding CAR that direct tumor cell killing.

45 utrophil NADPH oxidase activity and conidial killing.

46 f newborn cells to mediate Ab-dependent cell killing.

47 gen species for proopiomelanocortin neuronal killing.

48 cells (CARB19) that are resistant to CART19 killing.

49 ntrol of tumor progression, but limited cell killing.

50 variants to antibody-dependent bactericidal killing.

51 ng feature of CD4+ T cells that survived CTL killing.

52 evastating impact on human health worldwide, killing ~1.5 million individuals annually.

53 together increased the likelihood of wolves killing a bull instead of a cow.

54 ynergized with BCL-2 and MCL-1 inhibitors in killing ABC DLBCL cells.

55 ctivation reduces neutrophil chemotactic and killing abilities in vitro.

56 ecific pathways and mechanisms in macrophage killing ability, explored how pathogens subvert these re

57 e could be resulted from the direct bacteria-killing activities of PG-1, and the immunomodulatory eff

58 the CapsidCas13a(s) exhibit strong bacterial killing activities upon recognizing target genes regardl

59 ove those considered adequate for redirected killing activity against Env-expressing target cells but

60 uplexes and R loops and showed a potent cell killing activity associated with the formation of micron

61 The infectivity (cell-killing activity by infecting cells) of rNDV is unaltere

62 Here we show that the cell killing activity of PAF26 is dependent on extracellular

63 The tumor cell-selective killing activity of the adenovirus type 2 early region 4

64 This confers constitutive, RIPK3 independent killing activity to MLKL.

65 (+) T cell responses with S protein-specific killing activity were detected.

66 lls to acquire a broad-spectrum, innate-like killing activity.

67 are necessary for the import of PyoG and its killing activity.

68 Killing adult mosquitoes also reduces mosquito populatio

69 n vector control, it is widely accepted that killing adult mosquitoes would sharply reduce the propor

70 as no better than IVM alone for sterilizing, killing adult worms, or achieving sustained MF clearance

71 amma production, degranulation, and specific killing against NK-resistant lymphoma lines and primary

72 atholyte was collected and used ex situ as a killing agent for the inactivation of a pathogenic speci

73 utonomous release of the chemoattractant and killing agents result in long-range chemotactic attracti

74 s combination strategies that promote fungal killing and also provide effective immunomodulation.

75 ed in 88hIgG1, recapitulated the direct cell killing and avidity of 88mIgG3.

76 during T-starvation, while both the dramatic killing and chromosomal DNA loss in the ECA-deficient th

77 IgG1 mAb confers proinflammatory direct cell killing and enhanced avidity, an approach that could be

78 of cell competition could induce cancer cell killing and form the basis for novel anticancer therapie

79 CD2 signaling as key for mediating cytotoxic killing and granule polarization in freshly isolated CD8

80 d killing, and formate enhanced PGRP-induced killing and H(2)O(2) production in an FDH-dependent mann

81 er monocyte recruitment, increased bacterial killing and improved healing upon a secondary infection.

82 Finally, in vitro BMM killing and in vivo L. monocytogenes infection experimen

83 ine IgG3 residues underlying the direct cell killing and increased avidity via a series of constant r

84 CF macrophages exhibit reduced bacterial killing and increased inflammatory signaling.

85 ion in tissues, resulting in high tumor cell killing and low toxicity to surrounding tissues.

86 ctions since both direct microbial pathogens killing and matrix stabilization can occur simultaneousl

87 and had increased sensitivity to complement killing and phagocytosis by alveolar macrophages.

88 ith FcgammaR, maintains the opsonophagocytic killing and protective attributes of the antibody.

89 er growth that is based on both direct tumor killing and the triggering of protective immunity.

90 on and achieved both efficient in vitro cell killing and tumor regression in Mcl-1 dependent cancer m

91 Ham (mHam) assay (complement-dependent cell killing) and cell-surface deposition of C5b-9 to test th

92 ate responses including phagocytosis, fungal killing, and antigen presentation which can also shape t

93 n and the highest resistance to PGRP-induced killing, and formate enhanced PGRP-induced killing and H

94 ules involved in T cell-mediated target cell-killing, and monomeric teal fluorescent protein from the

95 mount robust T cell responses, enhance tumor killing, and provide clinical benefit.

96 mechanisms of anti-proliferation and/or cell-killing are consistent with the published mechanisms for

97 formation correlated with competency in prey killing, as well as with the phylogeny of A. oligospora

98 fic ex vivo restimulation assays and in vivo killing assays demonstrated that CD8(+) T cells produce

99 We then repeated Candida killing assays with thrombin-stimulated or unstimulated

100 cytokine secretion assays and imaging-based killing assays.

101 composition would increase peptide mediated killing at a distal site.

102 te concentration of 2 mug/mL is required for killing bacteria with colistin minimum inhibitory concen

103 honey appearing to be the most bactericidal, killing bacterial concentrations as high as 8 x 10(7) CF

104 nsulinemic hyperglycemia, highly selectively killing beta-cells by receptor-targeted photodynamic the

105 sting CR3-dependent differences in bacterial killing between sexes.

106 elk abundance, increased the odds of wolves killing bulls relative to cows.

107 re required for amebic trogocytosis and cell killing but not phagocytosis.

108 actose) resisted direct complement-dependent killing but was killed approximately 70% by 2C7-Ximab-E4

109 sure enhances resistance to human neutrophil killing, but this increase in pathogenicity was not due

110 The results provide an insight into assisted killing by an exogenous alkene with dark toxicity effect

111 al antiserum modestly increased phagocytosis/killing by an oxidative burst of murine neutrophils in v

112 ocuses on three different mechanisms of cell killing by checkpoint kinase I inhibitors (CHK1i).

113 agy control cancer-cell-intrinsic evasion of killing by CTLs and we highlight the importance of these

114 te to phenotypes associated with escape from killing by CTLs.

115 tibility class I (MHC-I) expression to evade killing by cytotoxic T lymphocytes (CTLs).

116 equent PD-L1 upregulation protects them from killing by cytotoxic T lymphocytes, yet dampens the anti

117 ht to enhance the potency and specificity of killing by driving lytic granule fusion at the synapse a

118 oncentration of CD11b blocking Ab, S. aureus killing by female BMN was greatly reduced compared with

119 ulation plays a critical role in target cell killing by freshly isolated human CD8(+) T cells, which

120 ich were found to be important for resisting killing by H(2)O(2) Finally, DeltamumR exhibited reduced

121 cterial burdens and more efficient bacterial killing by Ly6B.2(+) myeloid cells and macrophages compa

122 CD11b reduced both ROS levels and S. aureus killing by murine BMN from both sexes.

123 ion rather than on enhanced opsonophagocytic killing by neutrophils or protection against toxin-media

124 e the ability of S. aureus biofilms to evade killing by neutrophils.

125 T6SS), and prevents T6SS-dependent bacterial killing by P. aeruginosa.

126 not cytotoxic) dramatically increased their killing by proteasome inhibitors and inhibitors of ubiqu

127 Resistance to killing by serum enhances the capacity of Klebsiella pne

128 esponsible for preventing activation of, and killing by, serum complement could inform new approaches

129 elk population increased the odds of wolves killing calves relative to cows, whereas low SWE and poo

130 ngineered NK cells exhibit the capability of killing cancer cells more effectively.

131 uces PDE3A-SLFN12 complex formation, thereby killing cancer cells with high levels of PDE3A and SLFN1

132 ated, activated, and exhausted, with reduced killing capacity in vitro than blood CD8 T cells, potent

133 red migration in recipients, and deficits in killing capacity in vivo.

134 ficantly less in vitro degranulation and CD4 killing capacity than blood CD8 T cells.

135 nd CXCL12 and activation of their tumor cell killing capacity through IFNgamma and IL4, which led to

136 as9-based antimicrobials that lack bacterial killing capacity when the target genes are located on a

137 roliferation, cytokine production, and tumor killing capacity.

138 escent cytotoxic granules but wild-type-like killing capacity.

139 ast, no intereference was seen in tumor cell killing, caspase activation, or mitochondrial membrane d

140 polymerase 1 (PARPi) are highly effective in killing cells deficient in homologous recombination (HR)

141 with AMP was efficacious but showed delayed killing compared with 10 mg/kg.

142 DT2) by CDT2 knockdown can be more potent in killing cSCC cells than targeting CRLs or CRL4s in gener

143 resonance spectroscopy as well as bacterial killing curves against Pseudomonas aeruginosa were utili

144 Killing depends on T cell recognition of antigens presen

145 ATCC 43816 and RH201207 were able to resist killing despite being associated with substantial levels

146 -borne diseases through preventing bites and killing disease vectors.

147 Parasitological profiles, including rate of killing, docking, and molecular dynamics studies, sugges

148 stored chemical energy may enhance the cell-killing effect and boost the therapeutic effect.

149 Relative to BPS alone, an enhanced cell-killing effect is seen under hypoxic conditions both in

150 Mechanistically, the cell killing effects of PP were a result of inhibition of lip

151 wed that the catholyte possesses a long-term killing efficacy and continued to inhibit pathogen growt

152 sensitizers is an effective way to boost the killing efficacy of radiotherapy while drastically limit

153 s, and active GrB influenced its target cell-killing efficiency.

154 ne, and co-occurs with infection by the male-killing endosymbiont Spiroplasma.

155 pose that SMAPs are autonomous extracellular killing entities that deliver cytotoxic cargo targeted b

156 t the identified antibodies have utility for killing epithelial cell adhesion molecule-positive cells

157 sue rejection through individual target cell-killing events in vivo.

158 human CD8+ T cells reduced direct tumor cell killing ex vivo.

159 screen identified agents that enhanced cell killing following reduction of IL6 signaling.

160 8(+) T cell responses contribute to parasite killing following sporozoite immunization.

161 nificant temporal trends in rates of illegal killing for Southern, Central and Western Africa.

162 ts activation, recruitment, phagocytosis and killing functions of neutrophils, causing susceptibility

163 anism(s) driving this sex bias in neutrophil killing have not been reported.

164 dly around the globe, infecting millions and killing hundreds of thousands.

165 zes tumor cells to cytotoxic T cell-mediated killing, improving CAR T cell therapy.

166 such as mucociliary clearance and bacterial killing in CF airways.

167 sistance of the clade to complement-mediated killing in low levels of human complement likely present

168 nd PGE2 receptor blockade enhanced bacterial killing in Mphis.

169 Treatment with hIFNbeta promoted cell killing in neighboring, non-transduced cells, thus revea

170 This serum also induced bacterial killing in opsonophagocytosis assays, suggesting that HN

171 oduction and that defective L. monocytogenes killing in P2X5-deficient BMMs is substantially rescued

172 ycan-targeting mAb often induces direct cell killing in the absence of immune effector cells or compl

173 d and demonstrated potent and specific tumor killing in vitro and in vivo against both epithelioid an

174 roved ("i") chimeric mAb with enhanced tumor killing in vitro and in vivo.

175 ignificantly enhanced tumor cell binding and killing in vitro without harming healthy B cells.

176 es conferring sensitivity to T cell-mediated killing in vitro.

177 For effective lymphoma cell killing in vivo, we further functionalized CD22 ligand-m

178 ells play a key role in adaptive immunity by killing infected or cancerous cells.

179 reduce energy consumption while effectively killing insects.

180 Natural killer (NK) cell-mediated killing involves the membrane fusion of preformed lytic

181 This cancer cell killing is due to noncovalent association between Fc reg

182 Although poaching (illegal killing) is an important cause of death for large carniv

183 icantly improved peptide function and distal killing, it also reduced surfactant spreading.

184 in cells overlying the LRP or by physically killing LRP-overlying cells by ablation with optical twe

185 o 129hIgG1, converting it into a direct cell killing mAb with enhanced avidity and significant in viv

186 hypotheses have been proposed: liberalizing killing may decrease poaching incidence ('tolerance hunt

187 on with cell wall precursors is not the sole killing mechanism.

188 ibodies, the Th1-type cellular response, and killing mechanisms elicited by BPZE1 may hold prospects

189 everaging on several synergistic cancer cell killing mechanisms.

190 d pathways that enable cancer cells to evade killing mediated by cytotoxic T lymphocytes (CTLs), we p

191 y, and outperforms combination treatments in killing methicillin-resistant Staphylococcus aureus (MRS

192 Zika virus (ZIKV) causes microcephaly by killing neural precursor cells (NPCs) and other brain ce

193 either LCK to enhance the kinetics of tumor killing of 4-1BB CAR-T cells or SHP1 to tune down cytoki

194 c fibrosis neutrophils, wortmannin inhibited killing of a rough clinical isolate and not a smooth iso

195 e induction of optimal antifungal neutrophil killing of A. fumigatus spores.

196 ML blasts and enables T cell recognition and killing of AML.

197 roscovitine increases CF macrophage-mediated killing of antibiotic-resistant bacteria.

198 n initiating specific CD8(+) T-cell-mediated killing of antigen-loaded target cells in vivo.

199 TCR transfer to T cells of patients enabled killing of autologous and nonautologous melanoma.

200 to CD22 and selectins promote both targeted killing of B lymphoma cells and improved trafficking to

201 )-roscovitine and M3 significantly increased killing of B. cenocepacia and P. aeruginosa in CF MDMs i

202 (R)-roscovitine-mediated killing of B. cenocepacia was enhanced by combination wi

203 less efficient at inducing opsonophagocytic killing of bacteria by neutrophils in vitro, and were wo

204 odrugs we describe here synergize the direct killing of bacteria with a simultaneous rapid immune res

205 how these steps in turn influence host cell killing of bacteria.

206 ism of membrane-tension-induced (mechanical) killing of bacterial cells by non-translocating NPs.

207 ng a well-controlled platform for systematic killing of bacterial cells.

208 g minimal cell toxicity, displaying superior killing of bacterial reservoirs harboured within bladder

209 In contrast, killing of bronchial epithelial and renal cortical cells

210 on in IECs, and abrogated STING-mediated IEC killing of C. rodentium.

211 umor fibrosis, and unleashed T cell-mediated killing of cancer cells.

212 engineering enhances avidity and direct cell killing of cancer-targeting anti-glycan antibodies to cr

213 apsidCas13a(s), capable of sequence-specific killing of carbapenem-resistant Escherichia coli and met

214 moiety and axial ligands) contribute to the killing of cells and not just one dominant component.

215 NHE mediates killing of cells from multiple lineages and hosts, highl

216 ved D-lactate promotes Kupffer-cell-mediated killing of circulating pathogens.

217 imetics were highly synergistic in restoring killing of CLL cells.

218 nding resulted in an almost 10-fold superior killing of EGFR-overexpressing tumor cells compared with

219 phants comes from the Monitoring the Illegal Killing of Elephants (MIKE) program, which reports numbe

220 ng BTN3A1 therefore orchestrates cooperative killing of established tumors by alphabeta and gammadelt

221 ests have been happening for weeks since the killing of George Floyd in Minneapolis.

222 CD3+ T cells to GPRC5D+ MM cells and induces killing of GPRC5D+ cells.

223 es to delineate antibody-mediated uptake and killing of Gram-positive pathogens remain extremely limi

224 , this serum facilitated complement-mediated killing of H. pylori and E. cloacae, indicating its pote

225 ombinations of 3 mAbs mediated more than 30% killing of HIV-infected primary CD4+ T cells in the pres

226 AdRGD-PG-hIFNbeta vector provides extensive killing of human melanoma cells in vitro and a potent an

227 gger the clearance of viruses and subsequent killing of infected cells(1-4).

228 2 to 24 hours resulted in increased specific killing of infected cells, even with neutralization-resi

229 s, in deflecting antigen-specific CD8 T cell-killing of infected cells.

230 nd contribute to protecting the host through killing of infected, foreign, stressed or transformed ce

231 crophages (BMMs) exhibit defective cytosolic killing of L. monocytogenes We further showed that P2X5

232 binding mode; consequently, the direct cell killing of mouse IgG3 mAb is lost upon chimerization or

233 cubation of linezolid significantly improved killing of MRSA by dysfunctional neutrophils, which was

234 covitine's impact on macrophage function and killing of multi-drug resistant bacteria.

235 the intestinal epithelium and the effective killing of penetrant microorganisms, while suppressing t

236 ompared to wild-type cells, showed increased killing of phagocytosed E. coli and M. smegmatis Polypho

237 DNA cleavage in vitro impair P2 OLD-mediated killing of recBC-Escherichia coli hosts, indicating that

238 Increased phagocytosis promotes killing of S aureus and interleukin-8 release by neutrop

239 white blood cells showed defective in vitro killing of Staphylococcus aureus, consistent with a spec

240 tains epitopes that promote opsonophagocytic killing of streptococci.

241 pansion that causes, but also relies on, the killing of surrounding cells.

242 -subunit resulted in a significantly reduced killing of target cells and a >50% reduction in CG fusio

243 MART1 TCR-engineered T cells potentiated the killing of target cells.

244 ression of FHbp ID 896 resulted in augmented killing of the clade by LL-37.

245 ations achieved similar complement-dependent killing of three gonococcal mutants with glycan extensio

246 essing the ability to elicit T cell-mediated killing of tumor cells and prevent disease recurrence.

247 The killing of tumor cells by CD8(+) T cells is suppressed b

248 ly improved NK cell-mediated, EGFR-dependent killing of tumor cells compared with the NK cell engager

249 also mediate antitumour responses by direct killing of tumour cells and by participating in cellular

250 ease 2019 (COVID-19) pandemic and the police killings of George Floyd, Breonna Taylor, and multiple o

251 In this regard, potencies (EC(50) killing) of the best immunoligands were substantially im

252 ured surfaces and bacteria lead to bacterial killing or prevention of bacterial attachment and subseq

253 Tuberculosis remains a global health threat killing over 1 million people per year.

254 ldwide infecting nearly 6 million people and killing over 350,000.

255 t affects over 216 million people worldwide, killing over 445,000 patients annually.

256 uel continuity and prevent future fires from killing overstorey trees.

257 c effect in combination with gemcitabine for killing pancreatic cancer cells.

258 in different cells and may be ineffective in killing particular clones.

259 epithelia to produce antimicrobial peptides, killing pathogenic competitors, while S. epidermidis its

260 hazard and incidence during six liberalized killing periods, but that was outweighed by larger incre

261 Functional assays (killing, phagocytosis, transmigration, and respiratory b

262 centrioles did display substantially reduced killing potential, which was associated with defects in

263 upramolecular filament hydrogel, effectively killing primary GBM cells derived from patients.

264 with sensitivity across all species was the killing rate constant of the GUTS-RED-SD model (the redu

265 phate barriers achieved significantly higher killing rates than bednets alone.

266 Conversely linezolid impaired killing responses in healthy neutrophils.

267 cdysone receptor, to induce malaria parasite killing responses.

268 We also assembled the genome of the male-killing Spiroplasma, and find that it shows perfect gene

269 wo binding events and mediated protection by killing SPZ in the liver and by preventing their egress

270 akinra to whole blood reduced staphylococcal killing, supporting an IL-1beta functional significance

271 activity against various human cancer cells, killing SW48 colon cancer cells in particular with a sub

272 from these cells, making them susceptible to killing-termed kick and kill regimens-have been explored

273 re sensitive to hydrogen peroxide (H(2)O(2)) killing than wild-type A. baumannii However, mumR, which

274 pped tube across the bacterial cell surface, killing the bacterium.

275 a in macrophages and dendritic cells without killing the host cell.

276 small founding populations progress acutely, killing the host within days.

277 AB569 was also efficacious at killing the model organism Pseudomonas aeruginosa in bio

278 cellular Listeria monocytogenes (Lm) without killing the trophoblast.

279 can quickly lyse target cells in addition to killing them, the T6SS becomes a much more effective wea

280 an of the prey bacterium, which leads to its killing, thereby providing a growth advantage for P. aer

281 , and activation of natural killer (NK) cell killing through TNF-related apoptosis-inducing ligand (T

282 Rai, Virtuous Violence: Hurting and Killing to Create, Sustain, End, and Honor Social Relati

283 the way for the proinflammatory direct cell killing to promote antibody-dependent cellular cytotoxic

284 By killing trophozoite-infected erythrocytes, PfGARP could

285 tially more active in vitro than Nutlin-3 in killing tumor cells bearing wild-type p53, and effective

286 sensitivity of S. epidermidis to antibiotic killing under biofilm-forming conditions.

287 terferon gamma), proliferation, and specific killing upon CD19 target recognition.

288 Complement-dependent killing using the modified Ham test is blocked by either

289 rential degrees of drug effect on tumor cell killing versus inhibition of cell division, which may no

290 the innate immune system that are capable of killing virally infected and/or cancerous cells.

291 term impact of the catholyte on the pathogen killing was evaluated by plating Salmonella typhimurium

292 apparent defect in phagocytosis or bacterial killing was found.

293 However, cell killing was immediate upon re-polarization.

294 To investigate whether killing was mediated through surface components or relea

295 nse occurred in p53-defective cells and cell killing was not blocked by a pan-caspase inhibitor.

296 cell density, revealing more effective cell killing when more cancer cells are present.

297 ear to have a greater capacity for bacterial killing, which may contribute to control of bacteria in

298 fficient in enhancing PMN-mediated bacterial killing, while topical administration of such drug in a

299 n survey 1) or approving of disproportionate killing with conventional weapons (in survey 2).

300 organism containing numerous gamete (spore)-killing wtf drivers, offers a tractable system to test t