ライフサイエンスコーパス: kindling

1 f temporal-lobe epilepsy (a process known as kindling).

2 r hippocampus on 2 consecutive days (partial kindling).

3 18 adults >1 year of age at the beginning of kindling.

4 ng" effect rather than increase the speed of kindling.

5 otivational consequences of amygdala and VTA kindling.

6 tory changes reported to follow ischemia and kindling.

7 ronal responses were also observed after AGS kindling.

8 ay contribute to the development of amygdala kindling.

9 hanced seizure susceptibility to hippocampus kindling.

10 the initial and also more advanced stages of kindling.

11 s of the CA1 region of the hippocampus after kindling.

12 mA), acute pentylenetetrazol (PTZ), and PTZ-kindling.

13 duration of seizures in a rat model of rapid kindling.

14 rther exacerbated by pentylenetetrazol (PTZ) kindling.

15 shakes during both amygdala and hippocampal kindling.

16 in mediating the emergence of PTC during AGS kindling.

17 rs to be largely resilient to the effects of kindling.

18 ) or TRH-NPs for 7 days before initiation of kindling.

19 ed by maximal dentate activation (MDA) acute kindling.

20 jected into the hippocampus of rats prior to kindling.

21 tween 3 and 4 months old at the beginning of kindling.

22 1 to 2 seizures appeared following amygdala kindling.

23 s of astrogliosis, were present after 4 d of kindling.

24 o the SNr bilaterally 1 s after cessation of kindling.

25 ses to acoustic stimuli before and after AGS kindling.

26 ffect generalized clonus before or after AGS kindling.

27 onses to acoustic stimuli occurred after AGS kindling.

28 nus, which changed to burst firing after AGS kindling.

29 unkindled GEPR-3s, which is increased by AGS kindling.

30 forelimb (F and F) clonus, not seen prior to kindling.

31 ring generalized clonus before and after AGS kindling.

32 campus and temporal cortex in mice after PTZ kindling, a chronic model of rodent epilepsy.

33 receptors contributes to the development of kindling, a form of activity-dependent behavioral plasti

34 Hippocampal kindling, a model of mesial temporal lobe epilepsy, is d

35 Kindling, a model of temporal lobe epilepsy, induces a n

36 res (AGS), but following repetitive AGS (AGS kindling), an additional behavior, facial and forelimb (

37 that 2DG potently reduces the progression of kindling and blocks seizure-induced increases in the exp

38 s in perforant path (but not olfactory bulb) kindling and caused a twofold slowing in progression of

39 neuronal network for AGS as a result of AGS kindling and demonstrate a previously unknown involvemen

40 iseizure effect, impaired the progression of kindling and development of mossy fiber sprouting during

41 d enduring changes in transcription, such as kindling and environmental enrichment, in which CBP loss

42 r pathway that influences the progression of kindling and mossy fiber sprouting and suggest that NMDA

43 tested on both the development of amygdaloid kindling and on fully developed stage 5 amygdala kindled

44 term memory deficits associated with earlier kindling and prevented seizure-induced increases in Alzh

45 Here, we implemented the flurothyl kindling and retest paradigm in AS model mice to assess

46 ged increase of seizure susceptibility after kindling, and diminished sociability.

47 In particular, limbic kindling appears to enhance dendritic inhibition, indica

48 Using amygdala kindling as an indicator of sensitization development, w

49 contrast, animals receiving saline prior to kindling as well as phenobarbital-treated non-kindled an

50 obe epilepsy, lamotrigine-resistant amygdala kindling, as well as seizures induced by pilocarpine or

51 ollimated X-ray beam (18 MV) either prior to kindling, at kindling stage 3, or at kindling stage 5, b

52 g to epilepsy was examined using hippocampal kindling; autismlike behavior was studied using the soci

53 ds obtained once at the beginning and end of kindling, but only when compared to sham control values

54 nificantly increased by irradiation prior to kindling, but was unaffected by irradiation at kindling

55 These data suggest that perforant path kindling causes a persistent increase in hyperexcitabili

56 of forebrain neurocircuitry associated with kindling contributes to psychiatric disturbances involvi

57 ala-kindled seizure development and the post-kindling course in 58 cats (29 males and 29 females), in

58 recurrent evoked seizures early in the post-kindling course.

59 Olfactory bulb kindling developed similarly in wild-type, GluK1, and Gl

60 havioral and electrophysiological indices of kindling development and kindling-induced sprouting of h

61 at CLON and IDA can have opposing effects on kindling development in kittens and is the first report

62 f distinct neurotrophin receptors throughout kindling development in the rat via chronic intracerebro

63 epilepsy, but whether neurotrophins regulate kindling development is as yet unclear.

64 The rate of kindling development was significantly attenuated in -/-

65 l activity-determined functional plasticity (kindling development) as well as a structural plasticity

66 t BHK cells failed to display any effects on kindling development, while recipients of BHK-AK2 cells

67 tence of seizure expression at 4 weeks after kindling development.

68 icles containing TRH (TRH-NPs) could inhibit kindling development.

69 g focal irradiation at various points during kindling development.

70 n sleep than waking at both sites; (2) after kindling, each cat showed cyclic patterns, as follows: (

71 promoted epileptiform discharge in vitro and kindling epileptogenesis in vivo with partial gamma-amin

72 inate receptors in provoking seizures and in kindling epileptogenesis.

73 re focus (amygdala) significantly suppressed kindling expression when assessed by the number of stimu

74 re was performed 24 h later without DBS, the kindling failed to elicit any seizure signs in 6 of thes

75 imals receiving phenobarbital prior to daily kindling failed to recover within 2 months of testing.

76 tion pathways of GFP homologues, such as the kindling fluorescent protein and the Kaede protein, whic

77 timate kappa(2) values for the TagRFP-linker-kindling fluorescent protein tetrameric complex required

78 we determined the crystal structure of the "kindling fluorescent protein" asFP595-A143G (KFP) in the

79 otein, red fluorescent protein (TagRFP), and kindling fluorescent protein, and the S1,min --> S0 emis

80 the animals before or during the 5-week post-kindling follow-up during which seizures were evoked onc

81 However, it is not clear that kindling has a human correlate, so models in which an in

82 The pathway that mediates AGS kindling has been shown to involve the amygdala, which i

83 Taken together, our results demonstrate that kindling has subfield-selective effects on the different

84 led seizures were achieved by daily amygdala kindling, high frequency stimulation was delivered to th

85 These results are consistent with the kindling hypothesis but suggest a threshold at which the

86 Its requirement for epileptogenesis in kindling implicates TrkB and downstream signaling pathwa

87 ptor body (trkB-Fc) inhibited development of kindling in comparison with that seen with saline or hum

88 n AGS neuronal networks before and after AGS kindling in GEPR-3s.

89 antly to the emergence of PTC induced by AGS kindling in GEPR-9s, which is supported by recent prelim

90 rved in the MGB neuronal responses after AGS kindling in GEPR-9s.

91 f can produce limbic seizures which resemble kindling in some aspects.

92 d seizures before and 1-month after amygdala kindling in young cats (<1 year old; n=8; six female and

93 repetition of audiogenic seizure (AGS) ('AGS kindling') in the severe substrain of genetically epilep

94 Repeated, periodic induction of AGS (AGS kindling) in GEPR-9s increases seizure duration and indu

95 e report that repeatedly eliciting seizures (kindling) in the amygdala caused a long-term increase in

96 n of such processes, as well as blinking and kindling, in fluorescent proteins.

97 nstrated that the initial seizures evoked by kindling increase paired-pulse inhibition at 15-25 msec

98 After AGS kindling, increased neuronal firing occurred, and respon

99 tPA) was tested for its effects on the rapid kindling induced by a series of afterdischarges (ADs) tr

100 Partial amygdala kindling induced c-fos messenger RNA (mRNA) expression,

101 In contrast, partial hippocampus kindling induced c-fos mRNA in the hippocampus only.

102 AGS kindling induced significant increases in acoustic respo

103 Kindling induced widespread increases in non-AD-generati

104 The impairment of kindling-induced axonal sprouting in the null mutants co

105 We examined AGS kindling-induced changes in vlPAG extracellular action p

106 itical role of PRh in generation of this AGS kindling-induced convulsive behavior.

107 Kindling-induced granule cell axon sprouting as measured

108 intensities are unaffected by either NMDA or kindling-induced modulation of late paired-pulse depress

109 nd Narp-/- mice had increased sensitivity to kindling-induced seizures.

110 ological indices of kindling development and kindling-induced sprouting of hippocampal granule cell a

111 by enabling re-epithelialization while still kindling inflammation outside this niche until the barri

112 With the hope of kindling interest in this incredibly versatile range of

113 from tonic to burst firing suggest that AGS kindling involves increased cPRF excitability.

114 Kindling is a model of the neural plasticity that occurs

115 e structures from which to induce electrical kindling, is comprised of distinct nuclei that possess d

116 antagonist MK801 impedes the progression of kindling, it was of interest to determine whether MK801

117 ilarities to the viewing population, thereby kindling kin-motivated responses (for example, prosocial

118 icating and withdrawal episodes leading to a kindling-like increase in seizure susceptibility.

119 of the mechanism underlying the CIE induced kindling-like phenomenon observed in humans.

120 icating ethanol and withdrawal, leading to a kindling-like state of behavioral excitability.

121 BS, if well timed with the onset of amygdala kindling, may exert long lasting effects on the networks

122 troshock- and 6 Hz-induced seizures, corneal kindling, mesial temporal lobe epilepsy, lamotrigine-res

123 atment reduced seizure severity in the rapid-kindling model and reduced the number of spontaneous sei

124 In the kindling model in rats, BUM5 was more efficacious than b

125 isolated seizure, we implemented a modified kindling model in which we induced a seizure through amy

126 The exquisite sensitivity of agonists in the kindling model of epilepsy and the lack of evidence for

127 echanistic aspects of this phenomenon in the kindling model of epilepsy by applying focal irradiation

128 In this experiment, we used the electrical kindling model of epilepsy to determine whether seizures

129 on is increased after seizures evoked in the kindling model of epilepsy, but whether neurotrophins re

130 have been modelled in animals mostly by the kindling model of epilepsy, in which repetition of subco

131 locked the antiseizure activity of AP in the kindling model of epilepsy.

132 We show, in a kindling model of progressive focal epilepsy, that IEDs

133 Subsequently, we utilized the kindling model of temporal lobe epilepsy to determine if

134 Utilizing the rat kindling model of temporal lobe epilepsy, a single TRH m

135 ne (GBL) model of absence epilepsy, amygdala kindling model of temporal lobe epilepsy, and pilocarpin

136 In the kindling model of temporal lobe epilepsy, several physio

137 inhibitor 2-deoxy-D-glucose (2DG) in the rat kindling model of temporal lobe epilepsy.

138 Here, we developed an optogenetic kindling model through repeated stimulation of ventral h

139 e powerfully inhibits epileptogenesis in the kindling model.

140 d suppress secondary generalization in a rat kindling model.

141 ional BDNF(-/-) and TrkB(-/-) mice using the kindling model.

142 ogressive development of seizures in the rat kindling-model.

143 n suppressing seizure progression in the rat kindling-model.

144 Cgamma1 in hippocampi in the pilocarpine and kindling models in wild-type mice.

145 leptogenesis in the hippocampus and amygdala kindling models.

146 hic recordings before (n=2) and 1 month post-kindling (n=2); 5-min recording epochs were temporally a

147 We found: (1) before and after kindling, NE and 5-HT but not DA concentrations were sig

148 During kindling, neuronal synchrony increased along the lamella

149 nobarbital was coupled with daily electrical kindling of the amygdala beginning 48 h after a unilater

150 lutamate analogue, kainate, or by electrical kindling of the amygdala.

151 study examined the effects of perforant path kindling on 0-Mg(2+)-induced epileptiform bursting in th

152 s in the literature about chronic effects of kindling on monoamines and sleep-waking state patterns.

153 Here we examined the effect of kindling on stimulus-induced c-Jun N-terminal kinase (JN

154 determined the effect of repeated seizures (kindling) on 2-arachidonoylglycerol (2-AG) signaling on

155 it accelerated kindling rates and rapid post-kindling onset of multifocal spontaneous epilepsy with a

156 stribution of the mossy fibers after partial kindling or kainate-induced seizures.

157 tic risk exhibit an increase in the speed of kindling, or are they "prekindled"?

158 in (5-HT) before and during a 1-day amygdala kindling paradigm.

159 The alternating, post-kindling pattern suggested "rebound" effects which could

160 The kindling phenomenon is enhanced by the Ala143 --> Gly po

161 ble role of chromophore isomerization in the kindling phenomenon, we determined the crystal structure

162 factors for major depression impact on this "kindling" phenomenon?

163 sponse has been hypothesized to represent a 'kindling' phenomenon.

164 Furthermore, when the same amygdala kindling procedure was performed 24 h later without DBS,

165 These data indicate that specific kindling processes are initiated during the interval of

166 Our results indicate that kindling produces selective effects on the number and mo

167 ntial for theta oscillation negative peak as kindling progressed in the lamellar direction but not in

168 in a significant reduction in seizure ADD as kindling progressed, while the number of stimulations re

169 naptic activity, signaling that may modulate kindling progression and/or neuronal death.

170 The post-kindling progression can be stopped or minimized by susp

171 Repeated brief seizures evoked by kindling progressively increase seizure susceptibility a

172 urse of CBD administered immediately after a kindling protocol could halt the proepileptogenic plasti

173 ed the MMP2/9 inhibitor IPR-179 in the rapid-kindling rat model and in the intrahippocampal kainic ac

174 not efficacious in the basolateral amygdala kindling rat model of temporal lobe epilepsy, and it led

175 (2) CLON retarded and IDA accelerated kindling rate, defined as the number of afterdischarges

176 reased hippocampal excitability, accelerated kindling rate, prolonged increase of seizure susceptibil

177 scharge in the central amygdala and enhanced kindling rate.

178 he youngest animals also exhibit accelerated kindling rates and rapid post-kindling onset of multifoc

179 Post-kindling records in each cat were divided into two group

180 avioral seizure activity and compared to pre-kindling records.

181 Electrical kindling refers to the seizure-generating properties of

182 dic repetition of AGS in GEPR-9s induces AGS kindling resulting in expansion of the seizure network t

183 ntary synaptic currents (quantal size) after kindling results directly from a 75% increase in the num

184 The present study investigated whether AGS kindling results in changes in vlPAG neuronal firing by

185 zed clonus, but daily repetition of AGS (AGS kindling) results in an additional seizure behavior, fac

186 ndling, but was unaffected by irradiation at kindling stage 3, and significantly reduced by irradiati

187 ay beam (18 MV) either prior to kindling, at kindling stage 3, or at kindling stage 5, by exposure of

188 rior to kindling, at kindling stage 3, or at kindling stage 5, by exposure of the left amygdala to a

189 and significantly reduced by irradiation at kindling stage 5.

190 In the adult brain, repeated kindling stimulation of limbic pathways increases the NM

191 received daily treatments before receiving a kindling stimulus 3 h later.

192 Additionally, when seizures were induced by kindling, the number of stimulations required to evoke a

193 MDA channels correspond to those observed in kindling; the openings are considerably long, requiring

194 nes, SwLo rats had a lower final hippocampal kindling threshold and more wet dog shakes during both a

195 t undergoes a remarkable transition, termed "kindling", to a long-lived fluorescent state (lambda(em)

196 Kindling trials and afterdischarge (AD) were controlled

197 s appears to be independent of the number of kindling trials provided and cumulative AD.

198 Epileptogenesis assessed by development of kindling was inhibited in trkB(PLC/PLC) compared with co

199 The development of amygdaloid kindling was significantly retarded in 2R,4R-APDC (10 nm

200 eve full amygdala and hippocampal electrical kindling were similar in the two rat lines, SwLo rats ha

201 lation to induce status epilepticus (SE) and kindling-were used to induce seizures.

202 development of seizures in rats by amygdala kindling, which models temporal lobe epilepsy, allows th

203 familial Alzheimer's disease mouse model by kindling with the chemoconvulsant pentylenetetrazol and

204 diogenic seizures (AGS) leads to audiogenic 'kindling' with increased seizure duration and additional

205 present study asked whether partial amygdala kindling would affect the expression of conditioned fear