1 ies of PTEN, enabling structure-function and
kinetic analyses.
2 on opposite O(6)-methylG, using steady-state
kinetic analyses.
3 ncentrations was performed using two related
kinetic analyses.
4 ating were estimated by using single channel
kinetic analyses.
5 nteractions by equilibrium binding and rapid
kinetic analyses.
6 A, IsdB, IsdC, and IsdE by spectroscopic and
kinetic analyses.
7 NA ligase IV/XRCC4 via quantitative in vitro
kinetic analyses.
8 his specific reactivity by thermodynamic and
kinetic analyses.
9 can be interpreted using conventional enzyme
kinetic analyses.
10 dritic block, which significantly simplifies
kinetic analyses.
11 been paralleled by the development of modern
kinetic analyses.
12 in vitro digestion, equilibrium dialysis and
kinetic analyses.
13 l structures and performing pre-steady-state
kinetic analyses.
14 ese single-component precatalysts, including
kinetic analyses, (
12)C/(13)C isotope effect measurement
15 Detailed
kinetic analyses across different time scales, that is,
16 Computationally guided mutagenesis and
kinetic analyses allowed the identification of the enzym
17 Landscape and
kinetics analyses also indicate that the parallel beta-s
18 Using
kinetic analyses and a reconstituted in vitro transcript
19 Steady-state
kinetic analyses and binding assays were consistent with
20 Kinetic analyses and comparison with the bacterial SRP f
21 Using enzyme
kinetic analyses and computer simulations, we dissected
22 Kinetic analyses and fluorescent probe binding studies s
23 Here we show by
kinetic analyses and inductively coupled plasma emission
24 ransiently transfected HEK293 cells and used
kinetic analyses and modeling to describe the full range
25 ed GluN1/GluN2A single-channel currents with
kinetic analyses and modeling to probe these class-speci
26 Kinetic analyses and molecular modeling showed that the
27 ing from these computations were verified by
kinetic analyses and mutational studies.
28 Detailed
kinetic analyses and parameter estimation for a five-sta
29 Kinetic analyses and pH dependence studies of the wild t
30 e steps by steady-state and pre-steady-state
kinetic analyses and simulations.
31 ep mechanism was elucidated through detailed
kinetic analyses and suggests an enzyme isomerization mo
32 of these mutants were evaluated using enzyme
kinetic analyses and then assayed in three cancer cell l
33 Mutagenesis, single-channel
kinetic analyses and thermodynamic mutant cycle analyses
34 Using steady-state
kinetics analyses and molecular docking, we not only con
35 spectroscopy, electrochemistry, stopped-flow
kinetic analyses,
and EPR measurements were supported by
36 expressed proteins, in vitro transcription,
kinetic analyses,
and in vivo cell viability assays, we
37 combination of mutational, crosslinking, and
kinetic analyses,
and long-timescale molecular dynamics
38 Site-directed mutagenesis,
kinetic analyses,
and peptide inhibition assays have fur
39 Both thermodynamic and
kinetic analyses are possible.
40 Our results from mutagenesis and enzyme
kinetics analyses argue that a general base mechanism is
41 Steady state
kinetic analyses as a function of biotin, ATP, or a mini
42 inferred from multiple pieces of data using
kinetic analyses based on appropriate mathematical model
43 For
kinetic analyses,
blood activity was measured in 18 samp
44 o be obvious from the initial structural and
kinetic analyses but become less clear on deeper investi
45 Kinetic analyses by (1)H NMR spectroscopy showed less th
46 Kinetic analyses combined with microscale thermophoresis
47 Here, we present thorough
kinetic analyses combined with structural characterizati
48 Mutagenesis and
kinetic analyses confirm that the H-loop is particularly
49 nce ZPI forms a stable complex with FXa, and
kinetic analyses confirmed that PZ acted catalytically t
50 Kinetic analyses confirmed this hypothesis through an un
51 Here, we use
kinetic analyses coupled with IR spectroscopy to study h
52 Our detailed
kinetic analyses demonstrate a robust capacity for Cys-S
53 These detailed equilibrium and
kinetic analyses demonstrate that E295 is not irreplacea
54 phase, at the expense of mitotic cells, and
kinetic analyses demonstrate that Id2a is required for S
55 Steady-state
kinetic analyses demonstrate that one of these fragments
56 Kinetic analyses demonstrate that rephosphorylation of S
57 Our
kinetic analyses demonstrated that BCP can utilize a var
58 Detailed
kinetic analyses demonstrated that the in vitro phosphor
59 ty chromatography and intrinsic fluorescence
kinetic analyses demonstrated that the reduced heparin a
60 This, together with pre-steady state
kinetic analyses,
electron paramagnetic resonance spectr
61 The spectroscopic and
kinetic analyses enable a mechanism to be proposed for b
62 Using
kinetic analyses,
fluorescence binding, X-ray crystallog
63 Kinetic analyses following inhibition of TORC2, supporte
64 Steady-state
kinetic analyses for nucleotide incorporation by yeast p
65 Kinetic analyses for PglB revealed clear K(M)-only modul
66 A active site, which based on structural and
kinetic analyses has been tailored to bind the small, fo
67 Thermodynamic and
kinetic analyses have been applied to discover condition
68 Kinetic analyses have provided Arrhenius parameters, oxi
69 s has yet to be determined as structural and
kinetic analyses have provided contradictory results.
70 ctures of AlfC, combined with mutational and
kinetic analyses,
hydrogen-deuterium exchange mass spect
71 directed mutagenesis, mass spectrometry, and
kinetic analyses identified S(230) in hBVR (225)RNRYLSF
72 The results of
kinetic analyses imply that the aptamers bind AlkB away
73 es covalent labeling, mass spectrometry, and
kinetic analyses in a straightforward workflow applicabl
74 This was also reflected by
kinetic analyses in perfused liver, which showed a decre
75 on, small angle x-ray scattering, and enzyme
kinetic analyses in solution that the active form of DAP
76 Kinetic analyses,
independent exchange and crossover exp
77 Kinetic analyses indicate 4-aminobenzoate and 4-hydroxyb
78 In-depth
kinetic analyses indicate a wide range of accessible mac
79 Our phenotypic, metabolomic, and
kinetic analyses indicate at least three modes of discri
80 Kinetic analyses indicate one open and two distinct clos
81 In addition,
kinetic analyses indicate that although both AtAtg4s hav
82 Computational and
kinetic analyses indicate that competing mechanisms invo
83 Transport assays and
kinetic analyses indicate that Git3 has the greater tran
84 Kinetic analyses indicate that manganese increases the r
85 Kinetic analyses indicate that PFAAs undergo (3 + 2) cyc
86 Steady state
kinetic analyses indicate that Poliota is 100 fold more
87 Presteady-state
kinetic analyses indicate that Q509L does not affect ini
88 Kinetic analyses indicate that the sigmoidal behavior of
89 Kinetic analyses indicate that two mutations, P551S and
90 Our disaggregation landscape and
kinetics analyses indicate that tetramers probably act a
91 The dissociation constants and
kinetic analyses indicated roles for the arginines in tr
92 Steady-state
kinetic analyses indicated that Poliota and Poltheta ins
93 Kinetic analyses indicated that the PCBP-5' cloverleaf R
94 In
kinetic analyses involving labeling of either newly synt
95 bstantiated by product distribution studies,
kinetic analyses,
LFERs, Rehm-Weller estimations of Delt
96 Results from
kinetic analyses,
microtubule (MT) binding competition a
97 Biodistribution and
kinetic analyses of (11)C-donepezil time-activity curves
98 Kinetic analyses of (124)I-2'-fluoro-2'-deoxy-1-beta-D-b
99 we performed comprehensive thermodynamic and
kinetic analyses of 15 different proteins from the thior
100 Here, crystallographic and
kinetic analyses of 2-nt gap-filling DNA synthesis revea
101 results were validated with Michalis-Menten
kinetic analyses of 21 oligopeptide aminomethyl-coumarin
102 Reported here are thermochemical and
kinetic analyses of a new pincer-ligated rhenium complex
103 Kinetic analyses of a series of alternate nucleotides we
104 Interestingly, construction and
kinetic analyses of a series of UGT74F1/F2 chimeras have
105 Kinetic analyses of aggregation data at multiple monomer
106 The work here describes the
kinetic analyses of aluminum replacement for boron in a
107 ed on the basis of the crystal structure and
kinetic analyses of amino acid replacement variants.
108 Crystallographic and pre-steady state
kinetic analyses of antibody 34E4, which efficiently pro
109 Kinetic analyses of antiviral suppression of cell cultur
110 Kinetic analyses of Asn202 variants showed substantial d
111 Steady-state
kinetic analyses of Asn276Asp revealed slightly diminish
112 Kinetic analyses of Asn73 variants were consistent with
113 The model is examined via
kinetic analyses of Asp10, Thr16, His20, and Lys76 site-
114 igh resolution crystal structures and enzyme
kinetic analyses of Bacillus DNA polymerase I large frag
115 Kinetic analyses of changes in transcript levels upon co
116 Steady-state
kinetic analyses of CHO cytoplasmic tyrosyl-tRNA synthet
117 Steady-state and transient
kinetic analyses of class I CysRS and ValRS, and class I
118 Biochemical and
kinetic analyses of CPD mutants indicate that InsP6 bind
119 Here, we performed formal cellular
kinetic analyses of CTL019 in a larger cohort of 103 pat
120 End-point and rapid
kinetic analyses of dark-grown seedling growth revealed
121 Kinetic analyses of DNA binding and ATPase activities an
122 omoter mutants forming long-lived complexes,
kinetic analyses of duplex and bubble templates, dimethy
123 sults of tryptophan fluorescence binding and
kinetic analyses of DXP synthase and propose a new model
124 Here, using complementation and
kinetic analyses of enzymes recombinantly expressed in E
125 r inhibition by pregnanolone sulfate we used
kinetic analyses of equilibrium single-channel currents
126 Kinetic analyses of femtosecond transient absorption dat
127 Here, we performed single-molecule
kinetic analyses of fluorescently labeled AIP1 during th
128 Kinetic analyses of hypocotyl growth inhibition in respo
129 Kinetic analyses of kinase and pyrophosphatase parameter
130 Here, X-ray structures and
kinetic analyses of LIG1 complexes with undamaged and ox
131 Here, we present both crystallographic and
kinetic analyses of mutants designed to explore this iso
132 Kinetic analyses of mutants of Phe-259 or Thr-314 indica
133 Kinetic analyses of mutants with different amino acid su
134 ere, we performed steady-state and transient
kinetic analyses of myosins carrying one of seven missen
135 Kinetic analyses of nine additional insert mutants revea
136 Kinetic analyses of NMR spectroscopic data support a two
137 ed complex was suitable for pre-steady-state
kinetic analyses of polymerase activity.
138 Finally, we performed
kinetic analyses of progenitor activity after sublethal
139 Kinetic analyses of prothrombinase assembled with the mu
140 Steady-state
kinetic analyses of purified MERS-CoV and SARS-CoV PLpro
141 ing interface, together with native PAGE and
kinetic analyses of PZ binding to ZPI, that Tyr240 and A
142 Glycan microarray and
kinetic analyses of recombinant A(H7N9) HAs were perform
143 Our
kinetic analyses of reconstituted particles demonstrate
144 In contrast,
kinetic analyses of residues away from the RNA indicate
145 Kinetic analyses of SHV-1 and three SHV R244 (-S, -Q, an
146 Kinetic analyses of SHV-1, R244S, R244Q, R244L, and R244
147 Kinetic analyses of site-directed mutants prompted by th
148 oles were investigated for the first time by
kinetic analyses of site-specific replacement variants o
149 We performed detailed
kinetic analyses of specific steps in the hepatitis C vi
150 Using steady state and
kinetic analyses of tau polymerization at a variety of p
151 Kinetic analyses of the bending signal revealed an off r
152 The combination of structural and
kinetic analyses of the constructed mutants proved to be
153 solution NMR, isotopic labeling studies, and
kinetic analyses of the degenerate exchange of methane i
154 Kinetic analyses of the distribution of viral proteins i
155 Kinetic analyses of the measured time-activity curves yi
156 Detailed
kinetic analyses of the properties of selected inhibitor
157 Robust
kinetic analyses of the reaction mechanism are complicat
158 Steady-state
kinetic analyses of the selected AlsK and NanK variants
159 Kinetic analyses of the specificity of beta-PGM toward p
160 Transient
kinetic analyses of the variant-catalyzed reactions and
161 Kinetic analyses of the wild type and three variant Pta
162 established to perform detailed steady-state
kinetic analyses of these concurrent reactions.
163 Kinetic analyses of this comprehensive array of rHDL par
164 Kinetic analyses of vaginal infection with C. albicans i
165 In this paper, we report molecular
kinetic analyses of water spreading on hydrophobic surfa
166 Kinetic analyses of wild-type and chimeric E2s were perf
167 Kinetic analyses of wild-type and mutant Mcm2-7 reveal a
168 mixing experiments together with independent
kinetic analyses of ZPI-PZ and factor Xa-PZ-membrane com
169 Structural and folding
kinetics analyses of family members suggest that distort
170 Kinetics analyses of the oxidation by CcTET under neutra
171 Growth
kinetics analyses of various xenograft models showed the
172 Kinetic analyses offer informative insights about reacti
173 Second, Ala scanning and
kinetic analyses on residues in the SH2-catalytic domain
174 In this study, we performed
kinetic analyses on splenocytes of BALB/c mice that were
175 he distal end of the guide RNA, we performed
kinetic analyses on the high-fidelity (Cas9-HF1) and hyp
176 Viral and cellular
kinetic analyses performed in HIV-infected adults have y
177 Structural and
kinetic analyses place PRL-1 in the family of dual speci
178 Variable-temperature
kinetic analyses point towards a mechanism in which the
179 olding transition state structures and the 2
kinetic analyses presented can be used to assess the nuc
180 tructure of a lumiracoxib-COX-2 complex, the
kinetic analyses presented herein of the inhibition of m
181 V and TBR correlated with those derived from
kinetic analyses (
r(2) = 0.83-0.97, P < 0.001, slope = 0
182 Kinetic analyses reveal a distributive mechanism involvi
183 Structural and
kinetic analyses reveal a novel-peptide clamping mechani
184 Our
kinetic analyses reveal a reaction order of 1 in iodine,
185 Structural and
kinetic analyses reveal that 7j occupies the typical lig
186 Kinetic analyses reveal that BDPA-2Me rapidly reacts wit
187 In vitro
kinetic analyses reveal that CocE-L169K/G173Q displays a
188 Kinetic analyses reveal that inhibition is competitive w
189 Kinetic analyses reveal that modified nucleotides such a
190 Indeed, global
kinetic analyses reveal that NTE-Abeta42s form fibrils v
191 Kinetic analyses reveal that SSA impedes the A to B comp
192 Kinetic analyses reveal that the growing polymer chain a
193 Ligand complex structures and
kinetic analyses reveal that the N terminus governs the
194 In vitro
kinetic analyses reveal that WT GluRS2 selectively acyla
195 Strikingly, pre-steady-state
kinetic analyses reveal that, although human DNA polymer
196 ermal titration calorimetry and stopped-flow
kinetic analyses reveal uncoupled nucleotide affinity an
197 Furthermore,
kinetic analyses reveal uniformity in the rates of subst
198 logical complex (piccolo NuA4), steady-state
kinetic analyses revealed a kinetic mechanism that requi
199 Kinetic analyses revealed a two-step, ping-pong, zinc-hy
200 Enzyme
kinetic analyses revealed that a number of these product
201 Results of steady-state
kinetic analyses revealed that AsFMO exhibited negligibl
202 Kinetic analyses revealed that both lipids increase the
203 Detailed
kinetic analyses revealed that chloroquine and quinine c
204 Enzymatic
kinetic analyses revealed that EAEP generated uncompetit
205 Subsequent detailed
kinetic analyses revealed that loss of WRKY33 function r
206 ded with a decrease in manganese uptake, and
kinetic analyses revealed that manganese uptake depends
207 Transient
kinetic analyses revealed that mavacamten modulates mult
208 Kinetic analyses revealed that Mg dissolution to Mg(2+)
209 Steady-state
kinetic analyses revealed that Mn(2+) increases the cata
210 Pre-steady-state
kinetic analyses revealed that PMEO-DAPym-pp is a good s
211 Kinetic analyses revealed that prelatent antithrombin is
212 Comparative enzyme
kinetic analyses revealed that single substitutions are
213 Steady state
kinetic analyses revealed that successive truncation of
214 Single-channel
kinetic analyses revealed that the mean burst and interb
215 Single channel
kinetic analyses revealed that the mean open time of the
216 Kinetic analyses revealed that the mechanism responsible
217 Kinetic analyses revealed that the mutations in tRNA(Pyl
218 Kinetic analyses revealed that the specific activity, k(
219 Detailed
kinetic analyses revealed that tryptophan substitution a
220 Kinetic analyses revealed these mutations minimally affe
221 Site-specific mutagenesis and steady-state
kinetic analyses revealed two critical catalytic residue
222 Motility data, as well as
kinetic analyses,
revealed impairment of the force-gener
223 ovel activator, we conducted biochemical and
kinetic analyses revealing that SIRT6 is activated via a
224 Detailed
kinetic analyses (
RPKA, VTNA) suggest that (a) the catal
225 Kinetic analyses show a pH dependence of ligand binding
226 sociation rate for O2 by both nmHO and paHO,
kinetic analyses show an increase in dissociation rate f
227 iferase activity, real-time quantitative and
kinetic analyses show that donor-derived muscle stem cel
228 Kinematic and
kinetic analyses show that even on hard surfaces, barefo
229 Kinetic analyses show that Gun4 dramatically increases t
230 Kinetic analyses show that in the absence of IL-12 there
231 Kinetic analyses show that KPC-2 hydrolyzes cefotaxime m
232 Kinetic analyses show that the apparent first-order rate
233 Steady-state
kinetic analyses show that the turnover rates of His-257
234 Kinetic analyses show that Treg expansion is not a conse
235 Kinetic analyses showed that CoA is a strong feedback in
236 Enzymatic
kinetic analyses showed that cryptotanshinone was a mixe
237 Rapid-reaction
kinetic analyses showed that NADPH binds tightly (K(D) o
238 Kinetic analyses showed that RNA unwinding, not cleavage
239 Kinetic analyses showed that SIKE not only inhibits IRF3
240 Kinetic analyses showed that TgPhyA has similar properti
241 Rapid
kinetic analyses showed that the reaction proceeded by t
242 n epicatechin was used as a model inhibitor,
kinetic analyses showed that this catechol-containing di
243 ased sensitivity to the drugs, and transient
kinetic analyses showed that this hypersusceptibility wa
244 Kinetic analyses showed time-dependent inhibition, a hal
245 drug block of Kv11.1 gained though detailed
kinetic analyses such as this have a potential role in d
246 Spectroscopic data and
kinetic analyses suggest a model in which a molecule of
247 These
kinetic analyses suggest that copolymerizing a macromono
248 Kinetic analyses suggest that tyrosine nitration facilit
249 ced AR spreads over 30 min in the mouse, and
kinetic analyses suggest the presence of different sperm
250 Kinetic analyses suggested an AKR1A1 substrate preferenc
251 Kinetic analyses suggested that ifenprodil prevents the
252 Both the phylogenetic and
kinetic analyses support the conclusion that all TGTs ha
253 al feasibility of this approach to transient
kinetic analyses supporting further development towards
254 ifugation, X-ray crystallography, and enzyme
kinetic analyses that DAP epimerase from Escherichia col
255 ervations, when considered with accompanying
kinetic analyses that demonstrate cooperativity between
256 stinct activity profiles are correlated with
kinetic analyses that reveal that the ebvIL-10 dimer is
257 Here we report through
kinetic analyses that, in binding VWF, the ADAMTS13 cyst
258 Here we describe a novel
kinetics analyses that maps out the nonlinear dependence
259 esults confirmed previous thermodynamics and
kinetics analyses that suggested that the disruption of
260 tion with light-scattering, fluorescence and
kinetic analyses,
that the SH3 domain facilitates the bi
261 w using crystal structure, thermodynamic and
kinetic analyses,
that this natural antibiotic employs a
262 in addition to their use in transient state
kinetic analyses,
the computational approaches applied h
263 We have extended our
kinetic analyses to a high-fidelity polymerase, Klenow f
264 Here we used mutagenesis and enzyme
kinetic analyses to address these gaps in knowledge.
265 tance of the application of in vivo cellular
kinetic analyses to characterize clinical efficacy and C
266 We combine structural and
kinetic analyses to identify mechanisms that contribute
267 ere we used steady-state and presteady-state
kinetic analyses to investigate the mechanism of action
268 ith surface plasmon resonance imaging to add
kinetic analyses to measured binding interactions.
269 sed double mutant cycles and presteady-state
kinetic analyses to probe the putative interaction betwe
270 n shown by NMR spectroscopy and quantitative
kinetic analyses to undergo quantitative conversion to t
271 The steady-state
kinetic analyses under aerobic and anaerobic conditions
272 Kinetic analyses under single-turnover conditions reveal
273 Reaction
kinetic analyses using (19)F NMR and density functional
274 troscopic studies ((29)Si and (31)P NMR) and
kinetic analyses using a rapid-injection NMR apparatus (
275 Additional
kinetic analyses using both the natural and unnatural su
276 Kinetic analyses using purified 40S subunits revealed a
277 Kinetic analyses using R- and S-HPC as substrates reveal
278 Using quantitative
kinetic analyses,
we demonstrate that each component of
279 Through
kinetic analyses,
we demonstrate that the presence of th
280 g droplet-microfluidic technology and growth
kinetic analyses,
we demonstrate the presence of ibrutin
281 Using single-turnover and multiple-turnover
kinetic analyses,
we found that eG in its natural eG.C c
282 Using molecular modeling and binding
kinetic analyses,
we found that the strict spatial confi
283 Using site-directed mutagenesis and
kinetic analyses,
we show here that Ala657 and five cons
284 Combining structural and
kinetic analyses,
we show that (p)ppGpp binds the GMK ac
285 Using metabolomics and
kinetic analyses,
we show that GOR functions in parallel
286 Using NMR spectroscopy and
kinetic analyses,
we show that yeast Dcp2 resolves inter
287 ) simulations, and ligand-binding and enzyme-
kinetic analyses,
we studied the functional roles of the
288 In this study, using enzyme
kinetics analyses,
we demonstrate that ovothiols, 5(Npai
289 Kinetic analyses were completed using in vitro assays wi
290 Enzyme
kinetic analyses were conducted to determine the Km and
291 Viral and cellular
kinetic analyses were performed using a nonlinear mixed-
292 he mechanism of activation, biochemical, and
kinetic analyses were performed with Lys-290 variants of
293 Confocal fluorescence microscopy and uptake
kinetic analyses were used here to characterize cells tr
294 Structural and
kinetic analyses were used to investigate the role of fl
295 yll fluorescence induction and Q(A)(-) decay
kinetics analyses were performed.
296 been investigated by using spectroscopic and
kinetic analyses with betaine aldehyde and its isosteric
297 rs were determined by combining isotopic and
kinetic analyses with density functional theory estimate
298 Here, we combine
kinetic analyses with quantitative binding measurements
299 Kinetic analyses with several fatty acid hydroperoxides
300 Steady-state
kinetic analyses with the alternate disulfide substrates