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1  and plasticity and synaptic vesicle release kinetics.
2  from low n to high n species with different kinetics.
3 ntial adsorption of oxygen atoms with facile kinetics.
4 rphology, viral RNA profile, and replication kinetics.
5 ve substitution, which together enable rapid kinetics.
6 ct the polymer with pH-dependent degradation kinetics.
7 ssive decrease in all nerves, with different kinetics.
8        These lead to 'U-shaped' DPO4 folding kinetics.
9 capacity, reversibility, thermodynamics, and kinetics.
10 ions lead to an order-of-magnitude change in kinetics.
11 h could not be resolved by bulk luminescence kinetics.
12  of value for the estimation of fermentation kinetics.
13 on of reaction mechanisms and measurement of kinetics.
14 ns that, when combined, correlate to disease kinetics.
15 s, electro-catalysis, and transient reaction kinetics.
16 distinct mechanisms drive autoimmune disease kinetics.
17 nal transitions and asymmetric proliferation kinetics.
18 uires atomic-level understanding of reaction kinetics.
19 ing, slower digestion and leucine absorption kinetics.
20 d to more accurately describe DO consumption kinetics.
21 NA sites have a significant effect on search kinetics.
22 no-1,2,4-triazol-5-one following first-order kinetics.
23 tem can be applied to evaluate the enzymatic kinetics.
24 alysis framework to quantify the recruitment kinetics.
25 ication among parasites and influence growth kinetics.
26 hput analysis of grafted-from polymerization kinetics, accelerating reaction discovery, and optimizat
27                    By mapping visual pigment kinetics across the central retina, high fidelity IRD pr
28          Variation in translation-elongation kinetics along a transcript's coding sequence plays an i
29 ette Na(+) had no effect on the selectivity, kinetics, amplitude, rectification or reversal potential
30 ) are reabsorbed by 'high' efficiency uptake kinetics and 50-fold higher fractional urinary excretion
31 or binding taking into account the different kinetics and abundance of D1 and D2 receptors in the str
32 ition defect is due to altered nsDNA binding kinetics and affinity for the bacterial chromosome.
33 rter enables whole-brain imaging with faster kinetics and brighter fluorescence than commonly used nu
34 ing immiscible phases with tunable formation kinetics and can be further exploited to trigger the con
35 led electron transfer result in sluggish OER kinetics and catalysts are required.
36 ined catalytic activity, albeit with altered kinetics and cooperativity.
37  each cell division modulates nuclear growth kinetics and dictates size scaling throughout early deve
38 e presence and absence of protons reveals ET kinetics and diffusion behavior similar to other small c
39 both sides of the lesion within 1 h; but the kinetics and distribution of modification around the DSB
40 at respond to ligand with varying activation kinetics and dynamics.
41                The results revealed that the kinetics and electron flux of the cyclic redox reaction
42 ary alcohol follows clean pseudo-first-order kinetics and exhibits a sizable kinetic isotope effect.
43 n state theory fails to capture the reaction kinetics and explain the observed stereochemical distrib
44 nal cysteines (NCys) that proceeds with fast kinetics and exquisite selectivity, thereby enabling fac
45 -state chemical quench methods show that the kinetics and fidelity of DNA replication catalyzed by th
46 eabsorbed with 'very high' efficiency uptake kinetics and fractional urinary excretion of 0.025%, whe
47 gh seeded growth can accelerate the assembly kinetics and increase the optimal temperature by circa 4
48 nd quality control are produced with delayed kinetics and induce suboptimal CD8(+) T cell responses.
49 aproline, features rapid amide isomerization kinetics and isoenergetic amide bond geometries influenc
50  viral interferon antagonists in shaping the kinetics and magnitude of the host response during virus
51 uel generation can control reaction/assembly kinetics and materials' properties in life-like non-equi
52 g the molecules of DOM for understanding the kinetics and mechanisms through which DOM interacts with
53 stantially smaller and showed delayed growth kinetics and more distinct margins than tumors derived f
54 ence, with subcellular resolution, subsecond kinetics and nanomolar-to-submicromolar affinity.
55  is the first to measure mGlu(5) NAM binding kinetics and negative allosteric modulation of mGlu(5) r
56 c crowding nontrivially alters transcription kinetics and presents dynamic crowding within the bulk n
57 d with secondary organic aerosols (SOA), the kinetics and reaction mechanisms of superoxide (O(2)(*-)
58 chromatin remodeling was found to define the kinetics and selectivity of gene activation in response
59 sequential infections and correlate antibody kinetics and sequence of infections with disease outcome
60 articularly the ionic strength, dictates the kinetics and structures of the amphiphiles in the organi
61 ipid compositions and quantified interaction kinetics and the affinity of HuNoV virus-like particles
62               PFA decay followed first-order kinetics and the inactivation of MNV was governed by the
63 yzed the effect of those antibodies on serum kinetics and their in vitro and in vivo impact on anaphy
64  as well as their formation and dissociation kinetics and then reviews the fast-growing literature re
65   Elevated pCO(2) was reported to affect the kinetics and thermodynamics of biochemical conversions b
66 aterial imparts significant influence on the kinetics and thermodynamics of electron transfer, and fr
67                                 However, the kinetics and thermodynamics of nucleic acid interactions
68  information regarding the electron transfer kinetics and thermodynamics of redox-active species enca
69  residues reveals its contribution to enzyme kinetics and thermostability.
70 vide a foundational description of the virus kinetics and thus a deeper understanding of their clinic
71 parallel platform that measures the cleavage kinetics and time-resolved cleavage products for over 10
72  applied to characterize substrate transport kinetics and to test 294 top-marketed drugs for OATP2B1
73 w) induced water gelation on crystallization kinetics and water and fat proton relaxation were studie
74 plet-triplet annihilation pathway, where the kinetics and yield depend sensitively on the energies of
75                              EGFR activation kinetics, and consequently ERK signaling dynamics, were
76 , electrochemical redox, reaction mechanism, kinetics, and degradation.
77 lize, and be explained by simple mass action kinetics, and more likely to contain proteins with intri
78 ations of alpha-dicarbonyls, their formation kinetics, and presence of stabilizing residues in close
79 he complex, the association and dissociation kinetics, and the microviscosity, which governs translat
80 orphologies, drug loadings, and drug release kinetics, and thus, to control them.
81 centration measurements, steady-state enzyme kinetics, and X-ray crystallography, we show that the P1
82  same cell revealed that PPP2R5A degradation kinetics are comparable to those of APOBEC3G with a half
83 is and RNA velocity, we find that activation kinetics are delayed in aged MuSCs, suggesting that chan
84  transconductance and a 100-fold increase in kinetics are demonstrated.
85 edure requires that lipid-detergent exchange kinetics are in the fast exchange regime in order to fol
86 s obfuscated by labels, however, as reaction kinetics are inevitably perturbed.
87 and persistent mark of nucleus rupture whose kinetics are partially dictated by membrane resealing.
88 ion occurs in uls1Delta cells with wild-type kinetics, arguing that global histone depletion rather t
89 consequence of accelerated substrate binding kinetics as shown by saturation transfer difference NMR
90   Genetic complementation studies and enzyme kinetics assays indicate that B. fragilis UroS is functi
91 RFA) on Cu(II) reduction and Cu(I) oxidation kinetics at pH 8.2.
92 egime to the supply-limited regime of growth kinetics based on the optimized BNNT synthesis condition
93 n by enabling simulation of protein shedding kinetics based on tumor tissue-specific characteristics.
94                                      Binding kinetics between immobilized GCSF-R and all three differ
95 activation and KSHV replication with diverse kinetics between individual cells.
96 eronuclear single-quantum coherence spectra, kinetics, biochemical assays, and MS analyses, we show t
97 study, we show that Ag potency regulates the kinetics but not the magnitude of NFAT1 activation in si
98 ere we quantified Mediator-controlled Pol II kinetics by coupling rapid subunit degradation with orth
99 e because of expeditious synthesis/secretion kinetics (CCL3/4/5) and low activation thresholds (CCL1/
100 other bacterial systems, and yields bursting kinetics characteristic of eukaryotic systems.
101 his study analyzed transcriptional induction kinetics, chromosome looping, and enhancer RNA productio
102  translate networks comprised of mass-action kinetics, classic enzyme kinetics (Michaelis-Menten, Bri
103                                     PL decay kinetics corroborated by DFT calculations reveal a compl
104 d the system parameters of the model to cell kinetics data without treatment and then validated the m
105 ial [O(2) ], QO2 ) dependency that slows VO2 kinetics, decreasing CP and VO2max , increasing the O(2)
106           Prospective monitoring of mutation kinetics demonstrated that TKI-resistant low-level mutat
107  1) the dynamic complexity of the relaxation kinetics depends on the number of permeable species; 2)
108               Results obtained from in vitro kinetics drug release at human body temperature (37 degr
109                                       A fast-kinetics dual-ion-intercalation energy storage device is
110  the delays of fluorescence relative to P(+) kinetics during induction and relaxation, and in structu
111 ptoRaf and optoAKT differ in their signaling kinetics during regeneration, showing a gated versus gra
112 l reflection (TIR)-we elucidate the freezing kinetics during the solidification of a droplet while it
113 y based on Dynamic FBA (DFBA), called Linear Kinetics-Dynamic Flux Balance Analysis (LK-DFBA), to sat
114 mpounds followed slow-binding and reversible kinetics, e.g., methyl beta-(3,4-dihydroxyphenyl)-beta-p
115                However, the sluggish S redox kinetics, especially under high S loading and lean elect
116  species, useful in larger-scale modeling of kinetics, FCS, and FRAP.
117         Most reactions followed second-order kinetics, first order in amine and first order in electr
118                                 PFOA removal kinetics followed using high-performance liquid chromato
119  ), critical power (CP) and speed of the VO2 kinetics following exercise onset.
120  acute pathophysiology and biomarker release kinetics following mTBI, providing previously underappre
121 ld by (i) showing accelerated passive dosing kinetics for 68 cracked gas oil constituents with typica
122                     Quantifying the exchange kinetics for analytes relative to the exchange kinetics
123 energetic barriers and accelerating reaction kinetics for catalyzing the oxygen evolution.
124 r-IAB22M2C imaging is safe and has favorable kinetics for early imaging.
125                        The observed reaction kinetics for loss of THC on glass and cotton surfaces ar
126  diagnostic performance and favorable tracer kinetics for potential therapeutic applications.
127  The real-time data sets revealed extraction kinetics for VOCs present in these samples.
128 gh tumor uptake, sufficiently fast clearance kinetics from blood, low hepatobiliary excretion, fast r
129 mability from TMP and the high ion-transport kinetics from the carbonate systems, this facile strateg
130                       They have rapid twitch kinetics (full width at half-maximal stress: 11 +/- 1 ms
131 n of oxidizing lipid systems in terms of the kinetics governing both initiation and propagation phase
132 ts with ECG and EGC, but not in line with FQ kinetics, highlighted possible interferences of starch-f
133 VT and HVT-DeltavNr-13 showed similar growth kinetics; however, at early time points, HVT-DeltavNr-13
134 mance losses due to restricted ion-transport kinetics in a large thickness.
135 o promote the transgene expression level and kinetics in both adherent and suspension cells.
136 ation enables the characterization of enzyme kinetics in difficult cases.
137  ratio correlated with different contraction kinetics in knockout versus wild-type; (2) Aberrant acti
138 is pilot study demonstrated DPSMA uptake and kinetics in localized renal masses.
139                       However, the metabolic kinetics in most regions in the acute group were signifi
140         The decay of Fe(VI) had second-order kinetics in PB while Fe(VI) underwent an initial demand
141 initial demand followed by first-order decay kinetics in SEW.
142 lting in heterogeneous and delayed induction kinetics in single cells.
143 ms to monitor bacterial concentration, decay kinetics in the presence of various antibiotics (ciprofl
144                                 Inactivation kinetics in TLF and on dry SS followed the Weibull model
145 namics are crucial to quantitatively capture kinetics in V(D)J recombination.
146 sure H2B ubiquitylation and deubiquitination kinetics in vivo, we used a rapid and reversible optogen
147 pigallocatechin (EGC) exhibited slow binding kinetics (in the order of minutes), epicatechin gallate
148 n its intracellular concentration and dosing kinetics, including cell death.
149 urfactant formation as well as autocatalytic kinetics; indeed, no selection is observed when all reac
150  antibacterial potential and the degradation kinetics indicated first-order reactions.
151                                       Enzyme kinetics indicated that this RdRp efficiently incorporat
152 this has shown that RdRp nucleotide addition kinetics is stochastically interrupted by rare pauses of
153  sulfide crosslink structures on degradation kinetics is used.
154 titutions showed varied effects on transport kinetics (K(m) and V(max)) and substrate specificity.
155 tentiometry (OCP) to measure enzyme turnover kinetics, k(turn).
156 uitoes to characterize landing behaviors and kinetics, limitations, and the passive physiological mec
157 behavior of breast cancer cells via reaction kinetics may help unravel the mechanisms that underlie m
158 N-oxide (CNO) has been widely used, sluggish kinetics, metabolic liabilities and potential off-target
159 ised of mass-action kinetics, classic enzyme kinetics (Michaelis-Menten, Briggs-Haldane, and Botts-Mo
160 rting cell numbers with growth and reduction kinetics monitored using live cell imaging.
161  results derived from transient-state enzyme kinetics, Mossbauer spectroscopy, reaction product analy
162 the most widely employed tool to measure the kinetics of actin polymerization and the interaction bet
163 nal Ba(2+) than in Ca(2+); voltage-dependent kinetics of activation, inactivation, and deactivation;
164 flow (19)F NMR spectroscopic analysis of the kinetics of alkene difluorocyclopropanation and competin
165 imaging flow cytometry (iFCM) to explore the kinetics of allograft sEV release and the extent to whic
166                                    The rapid kinetics of AML1-ETO removal, when combined with analysi
167                                          The kinetics of antibody-antigen association are enhanced wh
168 on on the chemically-controlled dissociation kinetics of antibody-antigen pairs by the use of water-m
169 studied the effect of glycans on the binding kinetics of antiviral drugs to the influenza neuraminida
170 trength is more important parameter than the kinetics of binding.
171                                          The kinetics of bleb formation, its dependence on POM121, an
172 cking either phot2 or chup1 and analyzed the kinetics of both the onset and recovery of NPQ under equ
173 r in three of the four strains, the size and kinetics of Ca(2+) -dependent exocytosis, as well as the
174 rapies, cancer stage specific prognosis, the kinetics of cancer recurrence, as well as the limited da
175 strategies for improving the specificity and kinetics of Cas9 as a genome engineering tool and may in
176 at connect thermodynamic parameters with the kinetics of catalysis can provide new understanding and
177 cell tracking could be used to determine the kinetics of cell trafficking and arrest during the earli
178 r diffusion, rebinding, or slow deactivation kinetics of channels are candidates.
179 nimal models that recapitulate the long-term kinetics of clinical disease, which would provide insigh
180 and pramlintide better mimics the endogenous kinetics of co-secreted insulin and amylin, and holds pr
181 eptide 1 (CSP1) failed to modulate the onset kinetics of competence development in vivo The competenc
182  our porcine model of VCA tolerance, and the kinetics of cutaneous chimerism in both of these populat
183                         Small changes in the kinetics of dendritic excitatory currents amplify when r
184  in natural environments, thermodynamics and kinetics of divalent mercury Hg(II) chemical speciation
185 anslocating DNA can be exploited to tune the kinetics of DNA translocation.
186 drug on the antibody was found to affect the kinetics of drug release.
187 nd the effect of the imposed DeltaPsi on the kinetics of efflux was also studied in right-side-out me
188  liquid crystalline electrolyte modifies the kinetics of electrodeposition by introducing additional
189 cient approaches to boost the charge-storage kinetics of electrodes are still needed.
190  that GluA3 largely determines the ultrafast kinetics of endbulb synapses glutamatergic currents by p
191 ging rates are typically limited by the slow kinetics of Faradaic reactions and sluggish ion diffusio
192 d postnatal GBS acquisition, we assessed the kinetics of GBS GI colonization, progression to invasive
193  experimental observation and transformation kinetics of GBs in an elemental metal have remained elus
194 y enhancement and rapid transgene expression kinetics of GFP plasmids at no compromise of cell viabil
195                                          The kinetics of glucocorticoid-induced eosinopenia and bone
196 species-specific differences in the rate and kinetics of glucose consumption and glycolysis throughou
197  to investigate the salt-induced aggregation kinetics of gold (Au) and silver (Ag) nanoparticles (NPs
198 o the SAR1 GTP-binding pocket and alters the kinetics of GTP exchange.
199                                          The kinetics of heat-induced denaturation of alpha-lactalbum
200 nuclear pore complex blockade to monitor the kinetics of HIV-1 nuclear import and define the biochemi
201            We show that the strength and the kinetics of hybridization at large probe density can be
202                                          The kinetics of IgG avidity maturation during SARS-CoV-2 inf
203          Circular dichroism measurements and kinetics of inhibition indicated that the most active C-
204                              The aggregation kinetics of insulin were not significantly affected in t
205 plenishment of vitamin B-12 stores, from the kinetics of its plasma appearance in a 2-compartment mod
206 xchanges, they were found to control (1) the kinetics of ligand exchange, with bulkier thiolates caus
207 ch is attributed to genomic position and the kinetics of lineage commitment.
208                                   We use the kinetics of loop closure involving closely spaced (131-1
209                                     The fast kinetics of membrane fusion on the order of millisecond
210          Thus, understanding the fundamental kinetics of MOF-based molecular catalysis of electrochem
211              In this study, the inactivation kinetics of murine norovirus (MNV) by PFA, in phosphate
212 dulate the potency, selectivity, and binding kinetics of Na(V) channel ligands.
213              Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by S
214 and conventional SC-CO(2) dynamic extraction kinetics of oridonin from R. rubescens were well describ
215 g peanut protein, although variations in the kinetics of passage were observed between individuals an
216 on in diversifying both antigenicity and the kinetics of peptide display.
217 pulp and its perishability, the inactivation kinetics of peroxidase (POD) and polyphenol oxidase (PPO
218         In this work we directly compare the kinetics of photoreduction of six different heme protein
219 o explore the proton- and electron-gyroscale kinetics of plasma turbulence where the bulk of particle
220 ipants receiving modern ART to determine the kinetics of plasma viral rebound following ATI.
221  effector functions, which should affect the kinetics of plasma-virus decline.
222               In this study, we examined the kinetics of PRF and GrB mRNA and protein expression afte
223 neurogenesis but with deficits in cell cycle kinetics of proliferating progenitors in the hippocampus
224  the nanoscale can significantly enhance the kinetics of radical-mediated oxidation reactions-polluta
225 radiation, the block can be released and the kinetics of re-equilibration to the native conformationa
226 e subtle control over the thermodynamics and kinetics of reactions.
227 inetic approaches to determine the transient kinetics of recognition and repair of alkylated DNA by A
228 ificity may be increased by slowing down the kinetics of regulation: by increasing the energy for dis
229                            The force-coupled kinetics of ring-opening are probed by single molecule f
230 form, DropMap, to measure simultaneously the kinetics of secretion and other cellular characteristics
231                            Participation and kinetics of spectrally shifted far-red pigments are dire
232                             By measuring the kinetics of spread at early time points, we were able to
233 brium potential landscape topography and the kinetics of state switching.
234                                          The kinetics of symptom expression under natural pollen expo
235                     The binding affinity and kinetics of target engagement are fundamental to establi
236                        Here we show that the kinetics of tethered kinases follow a Michaelis-Menten-l
237 we investigated the urease-bound aggregation kinetics of the Au and Ag NPs which has not been explore
238                              We evaluate the kinetics of the bundling process by considering the ener
239                                 However, the kinetics of the channelrhodopsin-2 (ChR2) used for cell-
240                                          The kinetics of the first emission phase was mainly correlat
241                          Our analyses of the kinetics of the forward and reverse reactions of photool
242 tions, including how modulating the stepwise kinetics of the Hsp90 cycle-for example, by various coch
243  accurate determination of the mechanics and kinetics of the myosin working stroke with a smaller set
244  an effective way to improve selectivity and kinetics of the oxygen reduction reaction (ORR).
245 netics for analytes relative to the exchange kinetics of the standards results in greater accuracy an
246 ew new methods for future elucidation of the kinetics of their turnover in humans.
247 entions because of the specific transmission kinetics of this virus.
248 fy the nucleation, assembly, and disassembly kinetics of Tpm1.8 on single filaments and at the single
249                                          The kinetics of transport showed that exchange of S-componen
250 ineered to recruit either LCK to enhance the kinetics of tumor killing of 4-1BB CAR-T cells or SHP1 t
251                   We measure the association kinetics of unlabeled L-Tym by detecting its influence o
252 he reaction mechanisms and simulate reaction kinetics of UV/PAA process.
253             These profiles reveal extraction kinetics of various VOCs present in the extracted sample
254 at a mineralized surface zone influences the kinetics of water evaporation and the surface temperatur
255 troscopy (EIS) showed fast electron transfer kinetics of ZnO-rGO/ITO electrode.
256                    Further, the differential kinetics on this dimerization mechanism underlie an intr
257       We model the effect of U(VI) reduction kinetics on U isotopic fractionation during U(VI) reduct
258 ill coefficients describing the steady-state kinetics or substrate binding.
259 NRA over denitrification is not explained by kinetics or thermodynamics.
260 he ACh sensor retains the subsecond response kinetics, physiologically relevant affinity and precise
261                        Analysis of biomarker kinetics (PSP, routine markers) was performed on 90 pati
262 M/Fe(3)O(4)-40 following pseudo-second-order kinetics (R(2) > 0.97) and equilibrium isotherm data fit
263  is to describe and explain the seed tannins kinetics release in wine but also the impact of grape ma
264 rk unveils a genome-scale map of methylation kinetics, revealing highly variable and context-specific
265  ratio (DVR) was estimated using full tracer kinetics (reversible 2-tissue-compartment [2TC] model an
266                           The polymerization kinetics show a second order rate law, first order in bo
267 st intriguingly, depending on the initiation kinetics, stochastic elongation can either enhance or su
268 hereby enabling us to probe fast interaction kinetics such as those underlying formation of prenuclea
269 ing crystallographic, spectroscopic and fast kinetics techniques.
270 uman primates, both tracers exhibited faster kinetics than (11)C-GR103545 and comparable binding para
271 rametric variations of protein densities and kinetics than biological systems whose excitability is a
272 re found to be better predictors of reaction kinetics than calculated electrostatic potentials, sugge
273 exagonal-basket type; larger and with faster kinetics than in other models.
274 dent switch with 70-fold faster dissociation kinetics than streptavidin.
275 can have a pronounced effect on the observed kinetics that can manifest in significant run-to-run var
276 etween fluid instability and crystallization kinetics that determines the achievable feature sizes.
277 -lived charge separation with bias dependent kinetics that provide insights into the reorganization e
278 ence between folding in NDs and SUVs was the kinetics; the rate of folding was two- to threefold slow
279 s-Morales formalisms), and genetic repressor kinetics, thereby allowing a large class of models to be
280           Effective application of signaling kinetics to developing new therapeutics requires reliabl
281  platform for measuring arrestin recruitment kinetics to GPCRs using a high quantum yield, geneticall
282 rticoids induce KLF9 expression with similar kinetics to primary HBE cells in submersion culture.
283  we use a general model based on biochemical kinetics to quantify the combined effects of water conte
284 ar FX activation and antithrombin inhibition kinetics to the FVIIa.sTF complex.
285 t operates with ATP and GTP exhibits unusual kinetics toward F6P, as it appears to have an extremely
286 hybrid containing DHTKD1 displaying improved kinetics towards 2-oxoadipic acid.
287 e reactions evolve with profoundly different kinetics, undergoing autoinhibition (TBAT) or quasi-stoc
288 ignificant role in mediating the association kinetics, undergoing conformational rearrangement upon i
289 stable and exhibits unprecedented adsorption kinetics, up to 50 times faster than state-of-the-art ma
290              The extent to which interaction kinetics vary for the same RNA element across the transc
291 r surface photovoltages to be created, which kinetics vary with the composite architecture and last b
292              Informed by studies of reaction kinetics, we show that divergent sequence selectivity fo
293                           The brain nicotine kinetics were compared with those from smoking combustib
294                                 More complex kinetics were observed for the reactions of imidazolidin
295                                  Contractile kinetics were slowed in HF, with dramatically slowed rel
296 ts small changes in budding yeast initiation kinetics, which could not be resolved by bulk luminescen
297   Although using hydrogen-deuterium exchange kinetics with MS (HDX-MS) to interrogate the high-order
298  on the ribosome to regulate its interaction kinetics with SR, thereby reducing the nonspecific targe
299 ET-MS to the study of heterogeneous chemical kinetics with the reaction of gas phase O(3) and aqueous
300 ipate that future studies of viral infection kinetics with this reporter system will enable basic inv

 
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