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1 tained in a specialized structure termed the kinetoplast.
2 volved in replication and segregation of the kinetoplast.
3 tion and segregation of basal bodies and the kinetoplast.
4 ontaining a single enlarged nucleus plus one kinetoplast.
5 selective localization of acriflavin in the kinetoplast.
6 a decrease in the average amount of DNA per kinetoplast.
7 and localization of the protein only in the kinetoplast.
8 the mitochondrion, with a preference for the kinetoplast.
9 l cycle by inflicting specific damage on the kinetoplast.
10 duced population accumulated cells lacking a kinetoplast.
11 clusively for maintenance of the trypanosome kinetoplast.
12 complex mitochondrial genomes in nature, the kinetoplast.
13 organized in a complex structure called the kinetoplast.
14 es of proteins involved in the biogenesis of kinetoplasts.
15 the number of nuclei exceeding the number of kinetoplasts.
16 ning aggregated multiple nuclei and multiple kinetoplasts.
17 entification of the polypeptide synthesis in kinetoplasts.
18 e for a functional translation system in the kinetoplasts.
19 ase H activity, that is enriched in isolated kinetoplasts.
20 ssion of PNT1 led to cells having mislocated kinetoplasts.
21 he typical pattern is two EGJ in G1 phase (1 kinetoplast/1 nucleus, 1K1N) through S-phase (2K1N), dup
23 response of a complex DNA structure called a kinetoplast, a 2D network of thousands of linked rings a
24 werful trypanocides that act directly on the kinetoplast, a structure unique to the order Kinetoplast
25 croscopy revealed that PNT1 localizes to the kinetoplast, an organelle containing the mitochondrial g
26 -of-function phenotypes on repositioning the kinetoplast, an organelle that contains the mitochondria
27 ellular level, 23a blocks duplication of the kinetoplast and arrests cytokinesis, making it a new che
28 longer unattached flagellum and repositioned kinetoplast and basal body, reminiscent of epimastigote-
29 of basal body and its associated organelles kinetoplast and Golgi, as well as its role in cytokinesi
30 omatid mitochondrial DNA is contained in the kinetoplast and is composed of thousands of interlocked
31 codes a 70-kDa protein that localizes to the kinetoplast and is essential for both cell growth and ki
32 e phases and rates of morphological changes; kinetoplast and nucleus S phase, division and position,
35 ervation indicates an uncoupling between the kinetoplast and the nuclear cycle, resulting in cell div
37 yclic-form T. brucei enriched cells with two kinetoplasts and an enlarged nucleus possessing short me
40 tream form, however, enriched cells with two kinetoplasts and two nuclei connected through a microtub
42 and segregation of (a) the nucleus, (b) the kinetoplast, and (c) a set of cytoskeletal structures.
43 ment complex linking the basal bodies to the kinetoplast, and a segment of microtubule quartet linkin
45 tion of organelles, including the flagellum, kinetoplast, and nucleus, but were incapable of completi
46 cell showing an extended posterior end, two kinetoplasts, and an enlarged nucleus, apparently the re
48 vents, occurring in the flagellar pocket and kinetoplast, are critical for host-parasite interactions
50 l-size networks, we predicted sets of mutant kinetoplasts associated with defects in each of the five
52 nce of histone-like proteins, known as KAPs (kinetoplast-associated proteins), that neutralize the ne
54 uorescence staining showed a single nucleus, kinetoplast, basal body, and flagellum in the anterior p
55 their organelles, such as the mitochondria, kinetoplasts, basal bodies, and flagella, present as sin
56 ures in the trypanosome--the nucleus and the kinetoplast--begin to fluoresce within 1 min of introduc
57 by RNA interference had profound effects on kinetoplast biogenesis in Trypanosoma brucei procyclic c
60 ng anterior flagellum, and either one or two kinetoplasts, but only the anterior kinetoplast was asso
61 investigations of its polymer-like behavior, kinetoplasts can serve that role for 2D and catenated po
62 ative timing and duration of the nuclear and kinetoplast cell cycle that differs from the current mod
63 m has an increased number of one nucleus-two kinetoplast cells (1N2K) and a small population containi
67 leate cells (zoids), apparently derived from kinetoplast-dictated cytokinesis and cell division of th
72 asizes the role of basal body segregation in kinetoplast division and suggests a possible mechanism f
73 gella in these cells suggested the defect in kinetoplast division arose because of an inhibition of b
74 TbSAS6 at newly forming basal bodies; and 3) kinetoplast division is observed in G2 after completion
75 hesis was relatively unaffected and cell and kinetoplast division proceeded normally for several gene
76 In addition, we identified their role in kinetoplast division which may be also linked to overall
77 NAi in bloodstream trypanosomes also delayed kinetoplast division, and was further observed to inhibi
80 heritance appears uniparental for maxicircle kinetoplast DNA (kDNA) but biparental for minicircle kDN
81 rth: their mitochondrial genome, also called kinetoplast DNA (kDNA) forms an Olympic-ring-like networ
85 ically amplified whole linearized minicircle kinetoplast DNA (kDNA) of the Leishmania subgenus Vianni
86 sitivity of OligoC-TesT with those of nested kinetoplast DNA (kDNA) PCR, nested internal transcribed
88 mitochondrial genome of trypanosomes, termed kinetoplast DNA (kDNA), contains thousands of minicircle
93 otype upon induction of RNAi was the loss of kinetoplast DNA (kDNA), the cell's catenated mitochondri
106 We evaluated the serum levels of T. cruzi kinetoplast DNA (TckDNA), T. cruzi 18S ribosomal DNA (Tc
108 terference (RNAi) of p38 resulted in loss of kinetoplast DNA and accumulation of a novel free minicir
109 than wild type topo II alpha in decatenating kinetoplast DNA and also exhibits a 2-4-fold decrease in
110 approximately equal distribution of parental kinetoplast DNA between daughter kinetoplasts resulted i
113 ocalized in the antipodal sites flanking the kinetoplast DNA disk, as previously shown in C. fascicul
115 ctivity as judged by an inability to convert kinetoplast DNA from the catenated to the decatenated fo
119 fit the working hypothesis that the loss of kinetoplast DNA leads to a respiratory defect which then
123 mania parasite contains approximately 10,000 kinetoplast DNA minicircles, which are unequally distrib
124 ing the 75 C-terminal amino acids can rescue kinetoplast DNA missegregation but not the lack of ATOM
125 ultimately led to shrinkage and loss of the kinetoplast DNA network and cessation of growth of the c
126 ity found associated with the mitochondrial, kinetoplast DNA network in trypanosomatid protozoa.
127 ed guide RNAs upon segregation of the single kinetoplast DNA network into daughter cells at cell divi
128 tions with respect to the mitochondrial DNA (kinetoplast DNA network) in this organism are strikingly
130 The final disappearance of the stainable kinetoplast DNA occurred at a cell division in which all
131 ween the complex restriction patterns of the kinetoplast DNA of any of the parasites from Timargara c
133 these results suggest a point of control for kinetoplast DNA replication through the regulation of th
134 tor with genes involved in processes such as kinetoplast DNA replication, mitochondrial mRNA synthesi
145 ed by proteolysis of a helicase; the complex kinetoplast DNA system yields a clear view of how mitoch
147 g region of the TOP2 gene, which encodes the kinetoplast DNA topoisomerase, and have carried out dele
148 two kinetoplast ribosomal proteins with the kinetoplast DNA was observed by immunofluorescence, sugg
150 division in which all the remaining visible kinetoplast DNA was retained by one of the daughter cell
153 A time-course of DNA synthesis (nuclear and kinetoplast DNA), duplication of organelles (basal body,
154 ondrial genome of Trypanosoma brucei, called kinetoplast DNA, is a network of topologically interlock
155 have an unusual mitochondrial genome, called kinetoplast DNA, that is a giant network containing thou
159 parasitic heterocyclic dications can have on kinetoplast DNA, we have constructed ligation ladders, w
167 eplication, we now report that the T. brucei kinetoplast does move relative to the antipodal sites.
174 ubunit requirement; this subunit is the only kinetoplast-encoded product ultimately required for viab
178 se H activity gel analysis of whole cell and kinetoplast extracts shows that the enzyme is enriched i
180 , growth arrested cells accumulated multiple kinetoplasts, flagella and nucleoli, similar to the effe
181 setse flies and survive without a functional kinetoplast for reasons that have remained unclear.
185 nied by repositioning of the basal body, the kinetoplast, Golgi, and flagellar pocket, reflecting an
190 itance of the single mitochondrial nucleoid (kinetoplast) in the trypanosome requires numerous protei
192 ccumulation of cells with two nuclei and two kinetoplasts, indicating that cytokinesis was specifical
193 ng sickness parasite Trypanosoma brucei, the kinetoplast is a chain mail-like network of two types of
197 their complex mitochondrial genome, known as kinetoplast (k) DNA, composed of mutually catenated maxi
198 their single mitochondrion a highly complex kinetoplast (k)DNA, which is composed of interlocked cir
199 depends on maintenance and expression of its kinetoplast (kDNA), the mitochondrial genome of this par
203 re-positioned to a location posterior to the kinetoplast, leading to defects in cytokinesis and the g
204 in a kDNA independent cell line resulted in kinetoplast loss but was viable, indicating that PNT1 is
205 TPase subunit depletion, acriflavine-induced kinetoplast loss was specifically tolerated in these cel
206 ll division, including mispositioning of the kinetoplast, loss of flagellar connection, and preventio
210 ides were identified by fractionation of the kinetoplast membranes, labeled with [(35)S]methionine an
213 eloped to amplify the variable region of the kinetoplast minicircles of all Leishmania species which
214 rome c oxidase (respiratory complex IV) from kinetoplast mitochondria of the trypanosomatid protozoan
218 i, the first trans-acting factor involved in kinetoplast mitochondrial transcription to be identified
220 A editing systems have been described in the kinetoplast-mitochondrion of trypanosomatid protists.
225 These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of tw
226 plication of organelles (basal body, bilobe, kinetoplast, nucleus), and cytokinesis was obtained.
227 be repaired, suggesting that the kDNA in the kinetoplast of trypanosomatids has unique repair mechani
228 ells with abnormal complements of nuclei and kinetoplasts, often with the number of nuclei exceeding
229 a topologically intricate mitochondrial DNA (kinetoplast or kDNA) in the form of a network of thousan
230 e topologically intricate mitochondrial DNA (kinetoplast or kDNA) of Trypanosoma brucei brucei and re
233 muM), inducing a typical multiple nuclei and kinetoplast phenotype without being generally cytotoxic.
234 ese studies highlight how analysis of mutant kinetoplast phenotypes may be used to predict functional
235 ptide repeat-containing RNA binding protein, kinetoplast polyadenylation factor 3 (KPAF3), and demons
237 ide repeat-containing (PPR) proteins, termed kinetoplast polyadenylation/uridylation factors (KPAFs)
238 han 30 years, and although a large number of kinetoplast replication genes and proteins have been ide
239 rent triple function in coupling mitosis and kinetoplast replication with cytokinesis in T. brucei.
240 tified protein that couples both mitosis and kinetoplast replication with cytokinesis in the trypanos
243 of parental kinetoplast DNA between daughter kinetoplasts resulted in a decrease in the average amoun
244 and a colocalization of REH1, REL1, and two kinetoplast ribosomal proteins with the kinetoplast DNA
248 cycle, resulting in cell division driven by kinetoplast segregation with neither a priori S phase no
249 driven into cytokinesis and cell division by kinetoplast segregation without a completed mitosis, the
252 s encoded by both the nuclear genome and the kinetoplast, the unusual mitochondrial genome of these p
254 selective localization of acriflavin in the kinetoplast to photooxidize selectively the kinetoplast
255 nit of nuclear replication protein A and the kinetoplast topoisomerase II, accumulate periodically du
256 ence, thus indicating that the corresponding kinetoplast unedited mRNA is translated into a functiona
258 ei, while in cells overexpressing PLKty, the kinetoplast was mainly found at the posterior end of the
262 ar genome enclosed in a structure called the kinetoplast, which contains circular genomes known as ma
263 an African Trypanosomiasis, HAT), contains a kinetoplast with the mitochondrial DNA (kDNA), comprisin