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1 nal control (apicomplexa) or in its absence (kinetoplastids).
2 ainst neglected parasitic diseases caused by kinetoplastids.
3  a novel N-terminal sequence motif unique to kinetoplastids.
4   Three proteins have no similarities beyond kinetoplastids.
5 gulation of mitochondrial gene expression in kinetoplastids.
6 t ubiquitin-independent H3K76 methylation in kinetoplastids.
7 (modified peroxisomes) in diplonemids versus kinetoplastids.
8 thymine and created for CBE primer design in kinetoplastids.
9 he rewiring of the thiol-redox metabolism of kinetoplastids.
10 at creates functional mitochondrial mRNAs in Kinetoplastids.
11 ning of a pharma compound collection against kinetoplastids.
12 mitochondria, a situation thus far unique to kinetoplastids.
13 e, whereas the enzyme is active in all other kinetoplastids.
14  Intriguingly, Aurora B is conserved even in kinetoplastids, a group of early-branching eukaryotes wh
15                                  However, in kinetoplastids, a group of organisms that include medica
16 trifluralin, and GB-II-5 on apicomplexan and kinetoplastid alpha-tubulin is proposed.
17 n RNA editing in the single mitochondrion of kinetoplastids, an ancient lineage of eukaryotes, is a u
18  their localization pattern are conserved in kinetoplastids, an evolutionarily divergent group of euk
19                Bodo saltans is a free-living kinetoplastid and among the closest relatives of the try
20 hromosome conformation capture techniques to kinetoplastid and Plasmodium parasites has revealed fasc
21 lore J function in RNAP II termination among kinetoplastids and avoid indirect effects associated wit
22                                              Kinetoplastids and diplonemids prefer tropical regions a
23 ophic protistan lineages in marine plankton, kinetoplastids and diplonemids.
24                              However, in the kinetoplastids and euglenoids, the cytochrome c(1) prote
25 egulating Pol II transcription initiation in kinetoplastids and provides the first biological role of
26 mer formation, which is conserved across all kinetoplastids, and describe a chaperone function of the
27              Editing was first discovered in kinetoplastids, and recent work has resulted in the char
28 th ongoing drug discovery efforts in related kinetoplastids, and the exceptional models for rapid dru
29                                              Kinetoplastids are a group of flagellated protozoans tha
30                                              Kinetoplastids are a highly divergent lineage of eukaryo
31 ggest that kinetochores in organisms such as kinetoplastids are built from a divergent, but not ances
32                                              Kinetoplastids are eukaryotic microbes that display a wi
33                               The genomes of kinetoplastids are organized into polycistronic gene clu
34                                              Kinetoplastids are protists defined by one of the most c
35                                              Kinetoplastids are unicellular eukaryotic parasites resp
36 ns (RBPs) are the primary gene regulators in kinetoplastids as transcriptional control is nearly abse
37 g glycosyltransferases of bacteriophages and kinetoplastids, as the first inducible and the only othe
38 helped facilitating successful adaptation of kinetoplastids, at multiple occasions during evolution,
39                          We propose that the kinetoplastid AUR1 functional orthologue encodes an enzy
40              July 2005 marked a milestone in kinetoplastid biology research.
41 a flagellum but retains hallmark features of kinetoplastid biology, including polycistronic transcrip
42  thus are informative about the evolution of kinetoplastid biology.
43                              We propose that kinetoplastids build kinetochores using a distinct set o
44              The majority is conserved among kinetoplastids, but none of them has detectable homology
45  domain but is specifically related to other kinetoplastid calpain-related proteins by a highly conse
46 lated a functional orthologue of AUR1 in the kinetoplastids, causative agents of a range of important
47 able information about sterol composition of kinetoplastid cells suggest that the substrate preferenc
48                     Consequently, three anti-kinetoplastid chemical boxes of ~200 compounds each were
49  members of the large-pore channel family in kinetoplastids, consisting of proteins called unnexins,
50                 It is not understood how the kinetoplastid CPC assembles nor how it is targeted to it
51 ctedly possessed notable utility against the kinetoplastid disease visceral leishmaniasis (VL).
52 screening of representative examples against kinetoplastid diseases unexpectedly led to the identific
53 r parasitic infections, focusing on malaria, kinetoplastid diseases, and cryptosporidiosis.
54 ucturally complex circular mtDNA networks in kinetoplastids, divided into maxicircles and minicircles
55                                              Kinetoplastids encode a single nuclear tryptophanyl tRNA
56   Subsequently, it has become clear that the kinetoplastid endosomal system has an active and vital r
57 g of mitochondrial messenger RNAs (mRNAs) in kinetoplastids entails the coordinated action of three c
58                                           In kinetoplastids, every nuclear-derived mRNA contains an i
59 ed base at Pol II PTUs within members of the kinetoplastid family.
60  successful transfection of, the free-living kinetoplastid flagellate Parabodo caudatus with three pl
61     Paratrypanosoma confusum is a monoxenous kinetoplastid flagellate that constitutes the most basal
62                                              Kinetoplastid flagellates are known for several unusual
63                                              Kinetoplastid flagellates attach a 39-nucleotide spliced
64                                    Parasitic kinetoplastid flagellates represent a rare example of or
65                                           In kinetoplastid flagellates trans-splicing of spliced lead
66 ntial biological function of J in regulating kinetoplastid gene expression is discussed.
67            In Trypanosoma brucei and related kinetoplastids, gene expression regulation occurs mostly
68  clade that includes the previously reported kinetoplastid genes, all of which are homologs of TbTOP2
69 tid genomes, but it will also identify those kinetoplastid genome features lost during the evolution
70 chore components have been identified in any kinetoplastid genome, thus challenging this assumption o
71    To complement the sequencing of the three kinetoplastid genomes reported in this issue, we have un
72 stly expand the functional annotation of the kinetoplastid genomes, which in turn are critical for id
73                     Evolutionarily divergent kinetoplastids have an unconventional set of kinetochore
74 sively but cooperatively, and suggesting why kinetoplastids have evolved two DOT1 enzymes.
75 nd the interaction these parasites and other kinetoplastids have with their insect hosts.
76     Diplonemids are also the sister taxon of kinetoplastids, home to trypanosomatid parasites of glob
77 dicate that African trypanosomes and related kinetoplastid human pathogens are unusual in having inde
78 ondrial mRNAs is a characteristic feature of kinetoplastids, including Trypanosoma brucei.
79 romising therapeutic target for treatment of kinetoplastid infections, and underscore the possibility
80 AZ in adhesion and its relationship with the kinetoplastid-insect adhesion proteins (KIAPs) and the f
81                        Here, we discover the kinetoplastid-insect adhesion proteins (KIAPs), which lo
82           RNA editing in the mitochondria of kinetoplastids involves the addition and deletion of uri
83 a Unlike most eukaryotes, gene expression in kinetoplastids is predominately regulated posttranscript
84                               RNA editing in kinetoplastids is the post-transcriptional insertion and
85 toplast DNA (kDNA), the mitochondrial DNA in kinetoplastids, is a network containing several thousand
86 previously unidentified enzymes, such as the kinetoplastid J-base generating glycosyltransferase (and
87 e array of potential modes of action against kinetoplastid kinases, proteases and cytochromes as well
88                         The family member in kinetoplastids, KKT-interacting protein 1 (KKIP1), assoc
89 cture reveals the five cleavage sites of the kinetoplastid large ribosomal subunit (LSU) rRNA chain,
90            The near-intronless genome of the kinetoplastid Leishmania exhibits polycistronic transcri
91 NA gene locus has now been isolated from the kinetoplastids Leishmania tarentolae and Trypanosoma cru
92 g, this result contrasts the findings in the kinetoplastid Leptomonas, where mutations that restored
93 RNA binding and specificity are revealed for kinetoplastid ligases and the broader nucleotidyltransfe
94 onal dynamics and catalytic mechanism of the kinetoplastid ligation reaction.
95 ng probably originated in an ancestor of the kinetoplastid lineage and appears to have evolved in som
96  for tRNA processing in the deeply divergent kinetoplastid lineage and eukaryotes in general.
97 al, physiological, and molecular features of kinetoplastids, microsporidians, and sporozoans, as well
98    Uridine insertion/deletion RNA editing in kinetoplastid mitochondria corrects encoded frameshifts
99                               RNA editing in kinetoplastid mitochondria inserts and deletes uridylate
100             Regulation of gene expression in kinetoplastid mitochondria is largely post-transcription
101                               RNA editing in kinetoplastid mitochondria occurs by a series of enzymat
102                                           In kinetoplastid mitochondria, most of the molecular machin
103 nsertion/ deletion RNA editing, as occurs in kinetoplastid mitochondria, to be functional, and no sho
104 odel for U insertion/deletion RNA editing in kinetoplastid mitochondria.
105                                           In kinetoplastid mitochondrial mRNA editing, post-transcrip
106 ting inserts and deletes uridylates (U's) in kinetoplastid mitochondrial pre-mRNAs by a series of enz
107                                              Kinetoplastid mitochondrial RNA editing, the insertion a
108 ion compounds was screened against the three kinetoplastids most relevant to human disease, i.e. Leis
109  onto each protein-coding transcript, mature kinetoplastid mRNA acquire a hypermethylated 5'-cap stru
110                                The 5' end of kinetoplastid mRNA possesses a hypermethylated cap 4 str
111                                        Every kinetoplastid mRNA receives a common, conserved leader s
112 g sites in ND7 mRNA, the other characterized kinetoplastid mRNA supporting guide RNA-independent U-in
113                                              Kinetoplastid mRNAs possess a unique hypermethylated cap
114 t that the earliest acting components of the kinetoplastid nuclear DNA replication machinery - the fa
115 a highly diverse group of diseases caused by kinetoplastid of the genus Leishmania.
116 nt discovery in a lineage of protozoa called kinetoplastids of unconventional kinetochores with no ap
117                                              Kinetoplastid organisms, however, possess two highly div
118 mino acid sequences are conserved only among kinetoplastid organisms.
119 xt, including syntenic alignments with other kinetoplastid organisms.
120                    Thus, during evolution of kinetoplastids, Pam18 has been replaced by TbPam27.
121 m yielded the publication of three prominent kinetoplastid parasite genome sequences: Trypanosoma bru
122 n vitro than the parent compound against the kinetoplastid parasite Leishmania donovani.
123 selectively targeted to the flagellum of the kinetoplastid parasite Leishmania mexicana, but the mech
124 e we compared Erv homologues from yeast, the kinetoplastid parasite Leishmania tarentolae, and the no
125 environment is essential for survival of the kinetoplastid parasite Leishmania Unlike most eukaryotes
126                      Trypanosoma brucei is a kinetoplastid parasite of medical and veterinary importa
127 fide CPC proteins in Trypanosoma brucei, the kinetoplastid parasite that causes African sleeping sick
128                      Trypanosoma brucei is a kinetoplastid parasite that causes African trypanosomias
129 hosphoarginine/arginine kinase system of the kinetoplastid parasite Trypanosoma brucei, consisting of
130  Individual eukaryotic microbes, such as the kinetoplastid parasite Trypanosoma brucei, have a define
131   Here, we characterize KKT2 and KKT3 in the kinetoplastid parasite Trypanosoma brucei.
132                        Trypanosoma brucei, a kinetoplastid parasite, cycles between a tsetse fly vect
133                                          The kinetoplastid parasite, Trypanosoma brucei, undergoes a
134 terisation of the orthologue of SSNA1 in the kinetoplastid parasite, Trypanosoma brucei.
135 rms, which is another important aetiological kinetoplastid parasite.
136 sidues that are divergent between humans and kinetoplastid parasites and is consistent with all of ou
137 wn about topoisomerase genes and proteins of kinetoplastid parasites and the roles of these enzymes a
138                                              Kinetoplastid parasites are "living bridges" in the evol
139                                      As both kinetoplastid parasites are incapable of de novo purine
140 mportance for Trypanosoma brucei and related kinetoplastid parasites because these protozoa are not a
141                                              Kinetoplastid parasites cause lethal diseases in humans
142                      The endocytic system of kinetoplastid parasites is a highly polarized membrane n
143               A key morphological feature of kinetoplastid parasites is the position and length of fl
144 is (HAT) is a vector-borne disease caused by kinetoplastid parasites of the Trypanosoma genus.
145             African trypanosomes and related kinetoplastid parasites selectively traffic specific mem
146 e only Tim component so far characterized in kinetoplastid parasites such as Trypanosoma brucei is Ti
147                                              Kinetoplastid parasites such as trypanosomes and Leishma
148                               Leishmania are kinetoplastid parasites that cause the sandfly-transmitt
149                   Leishmania are flagellated kinetoplastid parasites that parasitize phagocytic cells
150 he diseases are caused by infection with the kinetoplastid parasites Trypanosoma cruzi, Leishmania sp
151 biologic functions in Leishmania and related kinetoplastid parasites underscores the potential signif
152 etion RNA editing is an essential process in kinetoplastid parasites whereby mitochondrial mRNAs are
153 roviding access to genome-scale datasets for kinetoplastid parasites, and supporting a variety of com
154           Leishmania species, members of the kinetoplastid parasites, cause leishmaniasis, a neglecte
155              This adhesion, conserved across kinetoplastid parasites, is implicated in having an impo
156 The editing complex, which is present in all kinetoplastid parasites, may thus be a chemotherapeutic
157 ite genome changes found in two well-studied kinetoplastid parasites, Trypanosoma brucei and Leishman
158 nsider the functional role of lipid rafts in kinetoplastid parasites, which are particularly rich in
159 ion of thymine residues within the genome of kinetoplastid parasites.
160 coding for calpain-related proteins in three kinetoplastid parasites.
161  potent, selective antimitotic agent against kinetoplastid parasites.
162 quence patterns following DNA replication in kinetoplastid parasites.
163 ponsible for most malaria cases, and of four kinetoplastid parasites.
164 cularization of the mitochondrial genomes of Kinetoplastid parasites.
165  interaction networks for the most prominent kinetoplastid pathogens.
166  on molecular phylogeny, we suggest that the kinetoplastids pathways evolved via gene duplication and
167  reports the enzymatic properties of various kinetoplastid PDECs and the crystal structures of the un
168 ome annotation suggested that early-diverged kinetoplastids possess a reduced set of basal transcript
169          Together these results suggest that kinetoplastids possess an unusual, conserved and essenti
170 ere we describe a selective inhibitor of the kinetoplastid proteasome (GNF6702) with unprecedented in
171                         GNF6702 inhibits the kinetoplastid proteasome through a non-competitive mecha
172 ery of GNF6702, a selective inhibitor of the kinetoplastid proteasome, which cleared parasites in mur
173 ing of this novel class of inhibitors of the kinetoplastid proteasome.
174 -terminal extensions are a common feature of kinetoplastid protein kinases.
175         The TbPTP1 structure, the first of a kinetoplastid protein-tyrosine phosphatase (PTP), emphas
176 ) editing takes place in the mitochondria of kinetoplastid protists and creates translatable mRNAs by
177                   All mitochondrial tRNAs in kinetoplastid protists are encoded in the nucleus and im
178 prominent role in RNA processing pathways of kinetoplastid protists typified by the causative agent o
179 f uridine insertion/deletion mRNA editing in kinetoplastid protists typified by Trypanosoma brucei.
180                                           In kinetoplastid protists, maturation of mitochondrial pre-
181 NA processing that occurs in mitochondria of kinetoplastid protists.
182                In common with the fungi, the kinetoplastid protozoa (and higher plants) synthesize IP
183  Sets of aligned nuclear rRNA sequences from kinetoplastid protozoa are also provided, which were use
184                                          The kinetoplastid Protozoa are responsible for devastating d
185  The screen expolits the observation that in kinetoplastid protozoa differentially expressed genes ar
186           Several mitochondrial mRNAs of the kinetoplastid protozoa do not encode a functional open r
187 quence of several mitochondrial mRNAs of the kinetoplastid protozoa is created only after the additio
188 quence of several mitochondrial mRNAs of the kinetoplastid protozoa is created through the insertion
189 , the genomes of trypanosomatids, a group of kinetoplastid protozoa of significant medical importance
190                                              Kinetoplastid protozoa such as trypanosomes and Leishman
191 ype of editing found in the mitochondrion of kinetoplastid protozoa, (b) the C-insertion editing foun
192 , and many unicellular eukaryotes, including kinetoplastid protozoa, are thought to synthesize exclus
193 ituation in the mitochondrion of the related kinetoplastid protozoa, in which TGA codes for tryptopha
194                       In the mitochondria of kinetoplastid protozoa, including Trypanosoma brucei, RN
195  is a complex process in the mitochondria of kinetoplastid protozoa, including Trypanosoma brucei, th
196 es that cause malaria, Toxoplasma gondii and kinetoplastid protozoa, including Trypanosoma cruzi and
197 shmania genus and does not recognize related kinetoplastid protozoa, such as Trypanosoma cruzi, Trypa
198 n has evolved within the mitochondria of the kinetoplastid protozoa.
199 ous organisms but it has not been studied in kinetoplastid protozoa.
200 riophage Rnl2 and the RNA-editing ligases of kinetoplastid protozoa.
201 odification occurring in the mitochondria of kinetoplastid protozoa.
202 n/deletion editing of mitochondrial mRNAs in kinetoplastid protozoa.
203 d serious debilitating illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi.
204 NA) of Trypanosoma brucei brucei and related kinetoplastid protozoan parasites has led to many report
205 the 80S ribosome from Trypanosoma cruzi, the kinetoplastid protozoan pathogen that causes Chagas dise
206 iced leader and U1 small nuclear RNAs in the kinetoplastid protozoan Trypanosoma brucei.
207 we document t-loops in Trypanosoma brucei, a kinetoplastid protozoan with abundant telomeres due to t
208                  Trypanosomatids, a group of kinetoplastid protozoans, possess a distinctive feature
209 s been used as a marker for the diversity of kinetoplastid protozoans.
210 f the KKT2 central domain from two divergent kinetoplastids reveal a unique zinc-binding domain (term
211                                              Kinetoplastid RNA (k-RNA) editing is a complex process i
212                                              Kinetoplastid RNA (kRNA) editing is a process that creat
213                                              Kinetoplastid RNA (kRNA) editing takes place in the mito
214 tic understanding and molecular inventory of kinetoplastid RNA editing and the editosome machinery.
215  RNAs, possible functions of RBP16 may be in kinetoplastid RNA editing and/or translation.
216                                              Kinetoplastid RNA editing consists of the addition or de
217 tion sites and is accordingly renamed KREN2 (kinetoplastid RNA editing endonuclease 2).
218              Our results suggest a model for kinetoplastid RNA editing in which chimeric molecules ar
219                                              Kinetoplastid RNA editing involves an exclusive class of
220                                              Kinetoplastid RNA editing is a posttranscriptional inser
221                   T4 RNA ligase 2 (Rnl2) and kinetoplastid RNA editing ligases exemplify a family of
222  Here we investigate the similarities in the kinetoplastid RNA editing process between human- and liz
223                                              Kinetoplastid RNA editing protein B3 (KREPB3, formerly T
224 form a heteromeric complex that functions in kinetoplastid RNA editing.
225                       Thus, p45 is the first kinetoplastid RNA-editing-associated protein (REAP-1) th
226 terization of LXE408, a structurally related kinetoplastid-selective proteasome inhibitor currently i
227                                              Kinetoplastid SepSecS enzymes are phylogenetically close
228  tract, which is common to the 3' end of all kinetoplastid SL RNA genes, and that more than six T's a
229 extracts from insect form cells of all three kinetoplastid species by using a modification of the one
230                         Across the different kinetoplastid species, each only has a single FLA/FLABP
231 RNAs of orthologous transporters in multiple kinetoplastid species, putative stem-loops from L. donov
232 tochondrial genes and edited mRNAs from five kinetoplastid species.
233  in extracts of three evolutionarily diverse kinetoplastid species: Trypanosoma brucei, Leishmania ma
234 any new eukaryotic parasite (apicomplexan or kinetoplastid) species or strains.
235  They possess several proteins thought of as kinetoplastid specific, as well as an extensive set of p
236 tial step towards finding effective and safe kinetoplastid-specific drugs.
237                              Absence of both kinetoplastid-specific enzymes in TbMTr2-/-/TbMTr3-/- li
238                      On the opposite side, a kinetoplastid-specific kinesin facilitates attachment of
239                                 pATOM36 is a kinetoplastid-specific OM protein that has previously be
240 t as a targeting signal for the glycosome, a kinetoplastid-specific organelle.
241  conserved core proteins of H/ACA snoRNPs, a kinetoplastid-specific protein designated methyltransfer
242 s the Polo-like kinase homolog TbPLK and the kinetoplastid-specific protein phosphatase KPP1, althoug
243  contain evolutionarily conserved as well as kinetoplastid-specific proteins, and component assembly
244 ng of an Aurora-like kinase, TbAUK1, and two kinetoplastid-specific proteins, TbCPC1 and TbCPC2.
245 rstanding the functional importance of these kinetoplastid-specific ribosomal features in protein-tra
246 % of these being potentially Leishmania- (or kinetoplastid-) specific.
247 vised six-transmembrane domain model for the kinetoplastid sphingolipid synthases consistent with the
248 DNA elements have been identified in several kinetoplastids such as Leishmania and Trypanosoma cruzi,
249                Control of gene expression in kinetoplastids such as trypanosomes depends heavily on R
250 om cryptogene encoded RNAs and is unique for kinetoplastids, such as Trypanosoma brucei.
251  is mechanistically distinct from editing in kinetoplastid systems.
252 nosomes are flagellated protozoan parasites (kinetoplastids) that have a unique redox metabolism base
253 reas fucosylated glycoconjugates are rare in kinetoplastids, the biosynthesis of the nucleotide sugar
254 er with freshwater euglenids and free-living kinetoplastids, the closest known nonparasitic relatives
255 n contrast to drug-induced episomes in other kinetoplastids, the T. brucei extrachromosomal NR-elemen
256                                   Like other kinetoplastids, they possess large transcriptional start
257 genome is 9.5 Mbp in size, the smallest of a kinetoplastid thus far discovered.
258 cessing; revealing a Conserved Regulators of Kinetoplastid Transcription (CRKT) Complex.
259 ne H2B mono-ubiquitin interaction, while the kinetoplastid Trypanosoma brucei di-methyltransferase DO
260 -specific phospholipase C (GPI-PLC) from the kinetoplastid Trypanosoma brucei.
261 urveyed 65 putative chromatin factors in the kinetoplastid Trypanosoma brucei.
262                                          The kinetoplastid Trypanosoma cruzi and the eukaryote crown
263  of cellular morphologies found in parasitic kinetoplastids (trypanosomatids).
264 otency and selectivity of this agent against kinetoplastid tubulin, GB-II-5 emerges as an exciting ne
265 Transcripts from many mitochondrial genes in kinetoplastids undergo RNA editing, a posttranscriptiona
266              Such differences are extreme in kinetoplastids, unicellular eukaryotic parasites often i
267  understanding of nuclear DNA replication in kinetoplastids was limited until a clutch of studies eme
268 in RNA-splicing and in RNAi systems (e.g. in kinetoplastids) which combine a distinct family of RNA-a
269 ochondrial genomes of E. gracilis and of the kinetoplastids, which is consistent with the phylogeneti
270 homology predictions to identify proteins in kinetoplastids with similarity to canonical outer kineto

 
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