ライフサイエンスコーパス: knock-in mouse

1 pileptic encephalopathy, the Gabrg2(+/Q390X) knock-in mouse.

2 he generation of a floxed GFP-C5aR1 reporter knock-in mouse.

3 xytamoxifen (OHT) into agonists in the AF2ER knock-in mouse.

4 hyperresponsiveness in the hGX-sPLA(2)(+/+) knock-in mouse.

5 oped a Runx1-green fluorescent protein (GFP) knock-in mouse.

6 cortical neurons derived from the PS-1 P264L knock-in mouse.

7 he circadian clock using PERIOD2 (PER2)::LUC knock-in mouse.

8 alpha loss-of-function phenotype of the C43S knock-in mouse.

9 n Erdj5 knockout mouse crossed with the P23H knock-in mouse and by adeno-associated viral (AAV) vecto

10 Here we developed a combined knock-in mouse and chemogenetic approach for cell-type-s

11 acterized a nonphosphorylatable nNOS(S1412A) knock-in mouse and evaluated its enteric neurotransmissi

12 Here, we show that the genetic knock-in mouse and human variant allele carriers exhibit

13 alization in OSNs, we generated a SLP3(eGFP) knock-in mouse and imaged the apical epithelium, includi

14 Using a lacZ/knock-in mouse and three lines of transgenic mouse harbo

15 rmed these findings in an analogous V region knock-in mouse and/or in non-Tg mice.

16 Using the Ptc-LacZ knock-in mouse as a second Gli responsive reporter, we s

17 Use of an En-1/tau-LacZ knock-in mouse as an autonomous marker for these neurons

18 y source of inherited instability in the Hdh knock-in mouse, as it is in man, but that the underlying

19 chain rearrangements in an anti-DNA H chain knock-in mouse, B6.56R.

20 ssues, we generated a Copa(E241K/+) germline knock-in mouse bearing one of the same Copa missense mut

21 ologous recombination was used to generate a knock-in mouse bearing the RyR2-V2475F mutation.

22 AT in the medial forebrain bundle (MFB) of a knock-in mouse (both sexes) were analyzed using confocal

23 s associate with mitochondria in Hdh(CAG)150 knock-in mouse brain and that this association increases

24 aptosomal fraction isolated from Hdh(CAG)150 knock-in mouse brain.

25 BDNF release and early neuropathology in HD knock-in mouse brain.

26 ted the repeat expansion in the variant SCA3 knock-in mouse by cell-type specific Cre/LoxP recombinat

27 e LxCxE domain in vivo, we have generated a "knock-in" mouse by replacing the wild-type cyclin D1 gen

28 We used gene targeting to generate a knock-in mouse carrying a null allele of enamelin (Enam)

29 We previously generated a knock-in mouse carrying the corresponding CMT2O mutation

30 We generated a knock-in mouse carrying the disease-associated mutation

31 The homozygous knock-in mouse carrying the missense P448L mutation almo

32 thways downstream of NOD2, we created a Nod2 knock-in mouse carrying the most common mutation seen in

33 cultured hippocampal neurons from a DeltaPIX knock-in mouse, CDI is absent.

34 lished in p53(QS) (Leu25Trp26 to Gln25Ser26) knock-in mouse cells after DNA damage, to determine the

35 A "redox-dead" knock-in mouse containing a C43S mutation exhibits pheno

36 Finally, using a novel knock-in mouse containing Cx43-MK4A mutation, we show in

37 An R4344Q knock-in mouse developed a cardiomyopathy-like phenotype

38 across an allelic series of heterozygous CAG knock-in mouse embryonic stem (ES) cell lines (Hdh(Q20/7

39 37Q knock-in mice, and found that homozygous knock-in mouse embryos were typically small in size and

40 In R137Q knock-in mouse embryos, the BER efficiency was severely

41 (wild-type) and Hdh(Q111) (mutant huntingtin knock-in) mouse embryos.

42 raction, we generated an EPCR point mutation knock-in mouse (EPCR(R84A/R84A)) which lacks the ability

43 ineage-specific enhancers using an enCRISPRi knock-in mouse establish in vivo evidence for lineage-re

44 By utilizing a knock-in mouse expressing a chimeric protein comprised o

45 Hence, we generated a knock-in mouse expressing a hemagglutinin (HA)-epitope-t

46 after antigenic stimulation, we generated a knock-in mouse expressing a modified form of the Cameleo

47 We subsequently generated an HAQ knock-in mouse expressing a mouse equivalent of the HAQ

48 A knock-in mouse expressing a non-cleavable GPR116 mutant

49 A new study reports a knock-in mouse expressing an identical mutation, bridgin

50 intact brain and acute brain slices from the knock-in mouse expressing epitope-tagged DAT.

51 rons in acute sagittal brain slices from the knock-in mouse expressing epitope-tagged DAT.

52 nal distribution of DAT using the transgenic knock-in mouse expressing hemagglutinin (HA) epitope-tag

53 ood pressure control in vivo, we generated a knock-in mouse expressing only a C42S 'redox-dead' versi

54 ECs isolated from a knock-in mouse expressing p27(Kip1) with a mutation of t

55 ossing Pten conditional knockout mice with a knock-in mouse expressing the Cre recombinase in the CD4

56 Cells from a "knock-in" mouse expressing a NF-kappaB p65 mutant bearin

57 armacoperone drug in a small animal model, a knock-in mouse, expressing a mutant GnRHR.

58 ent protein (GFP) in Arf(+/GFP) heterozygous knock-in mouse eyes.

59 Using a new knock-in mouse for activity-dependent genetic labeling (

60 y macrophages from a Zfp36-V5 epitope tagged knock-in mouse generated by CRISPR/Cas9-mediated genome

61 Here, using a newly generated, tagged Gli3 knock-in mouse (Gli3(TAP) ), we performed proteomic anal

62 We discovered that a knock-in mouse harboring a mutated thyroid hormone recep

63 collagen expression in vivo, we generated a knock-in mouse harboring a mutation that abolished the s

64 We generated the first patient-mimicking knock-in mouse harbouring the most common disease-causin

65 ARIalpha disulfide formation in "redox dead" knock-in mouse hearts resulted in larger infarcts (2-fol

66 d PKARIa disulfide formation in "redox dead" knock-in mouse hearts resulted in larger infarcts (2-fol

67 We generated a knock-in mouse in which a single amino acid residue, whi

68 e of these functions in vivo, we generated a knock-in mouse in which four amino acid substitutions in

69 1337-1344) describe a mutant p53 knock-in mouse in which normal tissues and some tumors h

70 We generated a knock-in mouse in which the endogenous H19/Igf2 ICR (mIC

71 nologic tolerance mechanisms, we generated a knock-in mouse in which the Ig heavy chain (HC) variable

72 In this study, using a TCR alpha knock-in mouse in which the knock-in alpha-chain can be

73 Here, we used a knock-in mouse in which the p53-Mdm2 negative feedback l

74 their importance for inhibition we created a knock-in mouse in which these residues are replaced by p

75 present study was to develop an NPC1 I1061T knock-in mouse in which to test proteostatic therapies.

76 of IL-23 in vivo, we have generated a novel "knock-in" mouse in which we have replaced the intracellu

77 se MPNs, we generated an inducible Jak2V617F knock-in mouse, in which the expression of Jak2V617F is

78 The Hdh(CAG)150 knock-in mouse is a valid model to evaluate early events

79 The early motor phenotype observed in the knock-in mouse is reminiscent of repetitive movements of

80 Using a human CTLA-4 knock-in mouse lacking FcgammaR function, antitumor effi

81 We found that a knock-in mouse lacking the CTD of GluA1 expresses normal

82 o test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1,

83 A knock-in mouse lacking the midregion, NLS, and C terminu

84 Using a PTEN knock-in mouse lacking the PDZ motif, and a cell-permeab

85 ineered a del595-612 PGHS-2 (Delta 18 COX-2) knock-in mouse lacking this 18-amino acid segment.

86 Here, we use a knock-in mouse line (mice expressing Angpt2(443)), a gen

87 We further created an SHOX/Shox2 knock-in mouse line (replacement of Shox2 with SHOX, ref

88 f this study was to characterize a Krt12-Cre knock-in mouse line for corneal epithelium-specific gene

89 Here, we generated a knock-in mouse line in which CB1-expressing neurons expr

90 ithin the DR in the current study, we used a knock-in mouse line in which expression of green fluores

91 c inducible fate mapping using a Gbx2(CreER) knock-in mouse line that descendants of Gbx2(+) cells as

92 We report a knock-in mouse line that expresses the isogenetic mutati

93 or Exclusively Activated by a Designer Drug) knock-in mouse line to manipulate intracellular Ca(2+) l

94 We generated a knock-in mouse line with an MS2 binding site (MBS) casse

95 hypothesis directly in vivo, we generated a knock-in mouse line with targeted mutation of the Ca(v)b

96 Here we characterized a Sox2-CreER knock-in mouse line with two independent reporter mouse

97 essing neurons, we generated a HS3ST-2-hPLAP knock-in mouse line, in which HS3ST-2-expressing neurons

98 ng a gene targeting approach, we generated a knock-in mouse line, in which N-terminal hemagglutinin e

99 Using a Grp-Cre knock-in mouse line, we show that the upper epidermis of

100 rs and defects in spindle orientation in our knock-in mouse line, which are absent in knockout animal

101 To study T cells in vivo, we developed a new knock-in mouse line, which expresses a fusion protein of

102 ating tissues, we engineered a Smarca4(FLAG) knock-in mouse line.

103 Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependen

104 ic changes in other organs, we generated two knock-in mouse lines on the C57BL/6N background harborin

105 such phenotypes, we have generated Hdh(Q111) knock-in mouse lines that are congenic for C57BL/6, FVB/

106 Two knock-in mouse lines that differ in the integration site

107 ddress these issues, we studied three Mrgprd knock-in mouse lines using an ex vivo somatosensory prep

108 Using a knock in mouse model with a Ser312 to Ala mutation, we s

109 imensional RNA-seq and proteomic data from a knock-in mouse model (Hdh mice) of Huntington's disease

110 in the brain and peripheral tissues of a HD knock-in mouse model (HttQ111).

111 By generating a knock-in mouse model (Nfkb2(ki/ki)) with three mutated r

112 sed an alpha9 cholinergic nicotinic receptor knock-in mouse model (of either sex) with enhanced media

113 associations were replicated in the Q175 Htt knock-in mouse model (p = 6.0 x 10(-8)) and in the trans

114 units in the homozygous calsequestrin 2-R33Q knock-in mouse model (R33Q) R33Q knock-in mouse model.

115 Furthermore, we created a FIP200-4A mutant knock-in mouse model and found that specifically blockin

116 ncy and mutation frequency, we established a knock-in mouse model by inserting a core Sgamma1 region

117 lopment of leukemia, we generated a FLT3/ITD knock-in mouse model by inserting an ITD mutation into t

118 A knock-in mouse model carrying the homologous p.Tyr97Cys

119 e the roots of this phenomenon, we created a knock-in mouse model carrying the mutation associated wi

120 A knock-in mouse model carrying the patient mutation p.Asn

121 We created a knock-in mouse model containing a potent dominant negati

122 mplications of PTMs on SRC-3, we developed a knock-in mouse model containing mutations at four conser

123 This knock-in mouse model enabled the use of a highly potent

124 yR2 in living cardiomyocytes, we generated a knock-in mouse model expressing a GFP-tagged RyR2 (GFP-R

125 Here, we generated a knock-in mouse model expressing a mutation that abolishe

126 p53 was further validated in vivo by using a knock-in mouse model expressing an acetylation-mimicking

127 We used a knock-in mouse model expressing the ACTA1 His40Tyr actin

128 Here we introduce a knock-in mouse model expressing the Atg16L1 T300A varian

129 We have characterized a knock-in mouse model expressing this dominant gain-of-fu

130 To our knowledge this is the first knock-in mouse model for a crystallin mutation causing h

131 n this study, we report the development of a knock-in mouse model for breast cancer where the endogen

132 Here we describe a knock-in mouse model for Cre-loxP-based conditional expr

133 nts performed in our laboratory using a DnaK knock-in mouse model generated by our group demonstrated

134 ment and progression, we took advantage of a knock-in mouse model harboring a mutation in the Thrb ge

135 We have developed a novel knock-in mouse model harboring heterozygous (Tubb4a(D249

136 We generated a knock-in mouse model harboring the c.365 G>C Fhl1 mutati

137 erspaced short palindromic repeats)-mediated knock-in mouse model hosting the Prdm16(Q187X) allele wa

138 s, we took advantage of a recently generated knock-in mouse model in which an axonal tracer, farnesyl

139 gic dysplasia and BM hyper-cellularity, in a knock-in mouse model in which cyclin E mutations were in

140 Here we demonstrate, using a knock-in mouse model in which GFRalpha1 is no longer loc

141 We have generated an FLT3/ITD knock-in mouse model in which mice with an FLT3/ITD muta

142 Here we describe a novel knock-in mouse model in which the prerearranged IgH locu

143 To address this, we generated a Brca2 knock-in mouse model lacking exons 4-7 and demonstrated

144 In a knock-in mouse model of a loss of function human variant

145 A novel Epg5 knock-in mouse model of a recurrent EPG5 missense varian

146 senilin-1 (APP/PS-1) human transgenic double-knock-in mouse model of AD.

147 (>=18-mo-old) Asxl1tm/+ mice, a heterozygous knock-in mouse model of CH, display genome-wide decrease

148 To address this, we generated a germline knock-in mouse model of cytoplasm-predominant Pten and c

149 study used a transgenic Col8a2(Q455K/Q455K) knock-in mouse model of early-onset FECD to identify the

150 nt these issues, we have studied a JAK2V617F knock-in mouse model of ET in which all megakaryocytes a

151 To our knowledge, this is the first knock-in mouse model of HD to show increased glial fibri

152 We have developed a new knock-in mouse model of HD with a chimeric mouse/human e

153 d the synaptic connectivity in a full-length knock-in mouse model of HD, the zQ175 mouse.

154 ies CAG length-dependent phenotypes in a Htt-knock-in mouse model of HD.

155 in cerebellar cell lines derived from a CLN3 knock-in mouse model of human Batten disease and control

156 We developed a CaV1.1-R528H knock-in mouse model of hypokalaemic periodic paralysis

157 these limitations, we generated an inducible knock-in mouse model of iRFP713.

158 ter understand these defects, we generated a knock-in mouse model of l-DOPA-responsive dystonia (DRD)

159 and early cone degeneration in the mutation knock-in mouse model of LCA.

160 We aimed to generate a knock-in mouse model of odontohypophosphatasia with a pr

161 We have developed a knock-in mouse model of OPMD (Pabpn1+/A17) that contains

162 strate that in the preclinical LRRK2(G2019S) knock-in mouse model of PD, subtype organization and pro

163 ore, EndMT is an early event in a JAK2-V617F knock-in mouse model of primary myelofibrosis.

164 Using a knock-in mouse model of SCA1 that recapitulates the sele

165 rived embryonic stem (ES) cells from a novel knock-in mouse model of SCD and tested a protocol for co

166 glutamine AR formed in cell culture and in a knock-in mouse model of spinal and bulbar muscular atrop

167 d the pattern of CAG repeat instability in a knock-in mouse model of spinocerebellar ataxia type 1 (S

168 Using a knock-in mouse model of the FAAH polymorphism that contr

169 investigate this question, we utilized a CGG knock-in mouse model of the Fragile X premutation with 1

170 of adult-born neurons, we developed a novel knock-in mouse model that allowed us to specifically and

171 MW-151 was tested in an APP/PS1 knock-in mouse model that exhibits increases in AD-relev

172 Here, we characterized a novel knock-in mouse model that expresses mouse HD gene homolo

173 bellar ataxia 17, we generated a conditional knock-in mouse model that expresses one copy of the muta

174 Here, we generated a double homozygous knock-in mouse model that incorporates the Swedish famil

175 Using a knock-in mouse model that recapitulates the clinical fea

176 Here, we describe a knock-in mouse model that reproduces the testicular atro

177 This knock-in mouse model thus links the ability of E2F1 to d

178 inal DNA-binding domain and also generated a knock-in mouse model to analyze the physiological signif

179 In this study we generated a Cbfb-GFP knock-in mouse model to characterize the normal expressi

180 n this study, we used the gp130(F/F) (Il6st) knock-in mouse model to examine the pathogenic contribut

181 ze et al use a tetracycline-inducible Dnmt3b knock-in mouse model to investigate how DNMT3B-mediated

182 a Neurog3-enhanced green fluorescent protein knock-in mouse model to isolate endocrine progenitor cel

183 We used an isogenic germline knock-in mouse model to study the effects of RIT1 mutati

184 A LGMD2I knock-in mouse model was generated to express the most f

185 f this E2F1 phosphorylation event in vivo, a knock-in mouse model was generated, in which serine 29 w

186 progression of breast cancer, we generated a knock-in mouse model where binding of Pygo2 to H3K4me(2/

187 Using a knock-in mouse model where the sequence for the enhanced

188 independent effects of SSRIs, we developed a knock-in mouse model whereby high-affinity interactions

189 s prognostic difference, we have generated a knock-in mouse model with a D838Y point mutation in FLT3

190 We have generated a knock-in mouse model with a homozygous Lig4 R278H mutati

191 We created a knock-in mouse model with an RNase H2 AGS mutation in a

192 role in disease pathogenesis, we generated a knock-in mouse model with NB disruption mediated by 2 po

193 We generated a knock-in mouse model with the 5-bp deletion in the Elovl

194 thogenesis of this condition, we generated a knock-in mouse model with this mutation.

195 We generated a novel Shank3 conditional knock-in mouse model, and show that re-expression of the

196 sis on these biochemical changes utilizing a knock-in mouse model, RMOR, in which MORs undergo morphi

197 sorders and profound deafness, and studied a knock-in mouse model, Ush1c c.216G>A, for Usher syndrome

198 In a phosphorylation-competent p300(G442S) knock-in mouse model, we demonstrate that HGP is now exq

199 Using a transgenic Gpr54-null IRES-LacZ knock-in mouse model, we demonstrate that neurons contai

200 Using a Hras knock-in mouse model, we demonstrate that specificity fo

201 h TYK2 kinase domain mutants and a TYK2 980I knock-in mouse model, we demonstrate that this single am

202 Using a conditional knock-in mouse model, we show that endogenous expression

203 Finally, using a knock-in mouse model, we validate that a specific varian

204 dy focuses on the MH susceptible G2435R-RYR1 knock-in mouse model, which is the murine equivalent of

205 veral adult tissues using a novel Tcf3-CreER knock-in mouse model.

206 in vivo using a novel Ncc T58M (human T60M) knock-in mouse model.

207 trin 2-R33Q knock-in mouse model (R33Q) R33Q knock-in mouse model.

208 filin-2 with the human disease, we created a knock-in mouse model.

209 in vivo properties of this mutant in a gene knock-in mouse model.

210 eta-SMMHC was further confirmed in vivo in a knock-in mouse model.

211 thylation levels in a tetracycline-inducible knock-in mouse model.

212 vector to express IVS-AAA in the brain of a knock-in mouse model.

213 activity were normal in the whole lung of a "knock-in" mouse model carrying an S32T mutation in the P

214 We have generated an R98C 'knock-in' mouse model of Charcot-Marie-Tooth type 1B, wh

215 gene-knock-in (A2BAR-knockout/reporter gene-knock-in) mouse model and showed receptor gene expressio

216 esis, we created a site-directed transgenic (knock-in) mouse model carrying a conditional MN1-TEL tra

217 ocampal neurons from a premutation (Fmr1 CGG knock-in) mouse model revealed impaired development of e

218 CGG-repeat length in a congenic (CGG-repeat knock-in) mouse model using 57 wild-type and 97 expanded

219 al neurogenesis in Huntington's disease (HD) knock-in mouse models and associated embryonic stem cell

220 ECD) using two alpha2 collagen VIII (Col8a2) knock-in mouse models and human FECD tissues.

221 Transgenic, knock-out, and knock-in mouse models and their intercrosses are more re

222 phosphorylation, we generated phosphomimetic knock-in mouse models by replacing conserved serines 171

223 Therefore, we generated cTnI knock-in mouse models carrying an R21C mutation to evalu

224 e pre-B cell lines and later demonstrated in knock-in mouse models carrying immunoglobulin heavy chai

225 Additionally, we generated and analyzed knock-in mouse models in which the FLNC-actin interactio

226 evelopment in vivo, we generated conditional knock-in mouse models in which the granulosa cells expre

227 ts cellular sources, we generated human apoE knock-in mouse models in which the human APOE gene is co

228 Here we show, using homozygous knock-in mouse models in which we replace murine Mc3r wi

229 enetic studies, Fam83h knockout and mutation-knock-in mouse models indicated that FAM83H does not ser

230 to different backgrounds and/or new knockout/knock-in mouse models is often time-consuming (6 months

231 e STN was studied in BAC transgenic and Q175 knock-in mouse models of HD.

232 l to CAG repeat length and is present in all knock-in mouse models of Huntington's disease (HD) with

233 Knock-in mouse models of PM revealed defects in embryoni

234 r phenotypes in the striatum of six distinct knock-in mouse models of the HD mutation.

235 r in both the inducible podocin knockout and knock-in mouse models resulted in successful amelioratio

236 sq2 derived from gene-targeted knock-out and knock-in mouse models that have recently become availabl

237 We have created two knock-in mouse models to study the mechanisms that regul

238 etermine the in vivo role of Ser571, 2 Scn5a knock-in mouse models were generated expressing either:

239 tant ras transgenes, conditionally expressed knock-in mouse models, and somatic cell knockout of muta

240 h Tbx18(LacZ), Tbx18(H2BGFP), and Tbx18(Cre) knock-in mouse models, we demonstrate LacZ and H2BGFP (n

241 Using two Igh knock-in mouse models, we found that RNA polymerase II a

242 Using humanized p53-mutant knock-in mouse models, we have identified a gain of onco

243 ion sites in IDH1 and IDH2 using conditional knock-in mouse models.

244 We include two SCA3 knock-in mouse models: our previously published model th

245 Using "knock-in" mouse models expressing mutant EpoRs, we found

246 evidence of metabolic defects in G2435R-RYR1 knock-in mouse muscle under basal conditions.

247 By using primary CTLs derived from a knock-in mouse of the CG membrane protein Synaptobrevin2

248 uman signal regulatory protein alpha (SIRPA) knock-in mouse on a Rag2(-/-) Il2rg(-/-) background (SRG

249 phorylation of the RyR at serine 2808 with a knock-in mouse prevented the decrease in spark-to-spark

250 phorylation of the RyR at serine 2808 with a knock-in mouse prevented the decrease in spark-to-spark

251 We believe that the G37S knock-in mouse provides an excellent animal model for st

252 the generation of a conditional ST-Cal-Light knock-in mouse provides an opportunity to tag active neu

253 eckstrin homology (PH) domain point mutation knock-in mouse (R302, 303A), in which ARAP3 is uncoupled

254 a novel mouse model of CDD, the Cdkl5(R59X) knock-in mouse (R59X), to investigate changes in synapti

255 oylated at residue cysteine 75 (Cys75) and a knock-in mouse representing mutated Cys75 to serine (AEG

256 The knock-in mouse represents an excellent mammalian model f

257 To address this question, we used a knock-in mouse, RMOR (for recycling MOR), in which genet

258 ion-dependent proteasomal degradation in the knock-in mouse RPE due to misfolding.

259 ing HDAC3 improves the phenotype of the SCA1 knock-in mouse (SCA1(154Q/2Q)), the most physiologically

260 Analysis of the Ter349Glu rhodopsin knock-in mouse showed a rapid, early onset degeneration

261 function in vivo in several tissues, using a knock-in mouse strain expressing a p53 mutant compromise

262 An inbred genetic knock-in mouse strain expressing the variant BDNF recapi

263 We recently described a knock-in mouse strain in which the substitution of 2 ami

264 In addition, the Runx1-IRES-GFP knock-in mouse strain should prove valuable for investig

265 oped a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mas

266 A FMF-knock-in mouse strain that expresses chimeric pyrin prot

267 st this hypothesis, we used an Id2-CreER(T2) knock-in mouse strain to lineage trace the distal epithe

268 ciated mutation induces skin inflammation, a knock-in mouse strain was generated that allows tamoxife

269 ar composition of these nAChRs, we studied a knock-in mouse strain with a leucine-to-alanine mutation

270 ed Flag- and haemagglutinin-tagged cyclin D1 knock-in mouse strains that allowed a high-throughput ma

271 models of HD, the R6/2 transgenic and CAG140 knock-in mouse strains, we demonstrate that adipose tiss

272 onventional hFcRn transgenic mice and in new knock-in mouse strains.

273 de, which predate overt pathology in Hdh CAG knock-in mouse striatum, implicate enhanced N-methyl-D-a

274 For example, recent knock-in mouse studies have shown that MDM2 heterooligom

275 of the likely pathogenic FOXI3 variants, and knock-in mouse studies strongly support the involvement

276 However, the knock-in mouse survives and develops a wide range of str

277 curate model of disease, we have generated a knock-in mouse (T32KI) carrying the c.1465G > A (p.D489N

278 We developed a knock-in mouse that biologically recapitulates a common

279 lation in vivo, we used a Cys42Ser PKG1alpha knock-in mouse that cannot transduce oxidant signals bec

280 nt CK2 activation in T cells, we generated a knock-in mouse that expresses a CD5 protein containing a

281 e of NF-kappaB in inflammation, we created a knock-in mouse that expresses a constitutively active fo

282 To do this, a knock-in mouse that expresses an RGS-insensitive (RGSi)

283 To address this issue, we generated a double knock-in mouse that expresses V regions of a somatically

284 nerated a floxed tandem dye (td)Tomato-C5aR2 knock-in mouse that we used to track C5aR2 expression in

285 aches, including a nonphosphorylatable STIM1 knock-in mouse, that STIM1 phosphorylation is not requir

286 By developing a knock-in mouse to fluorescently tag Arc alleles, we stud

287 A novel CRISPR-based CaMKIIdelta knock-in mouse was created in which kinase activation by

288 A knock-in mouse was produced that replaced GFRalpha1 with

289 This redox-dead knock-in mouse was substantively deficient in hypotensiv

290 We previously characterised a TDP-43(Q331K) knock-in mouse, which demonstrated behavioural phenotype

291 d tandem-dye Tomato (tdTomato)-C3aR reporter knock-in mouse, which we used to monitor C3aR expression

292 The C5aR2 knock-in mouse will help to reliably track and condition

293 The floxed C3aR knock-in mouse will help to reliably track and condition

294 The novel floxed C5aR1 reporter knock-in mouse will prove useful to track C5aR1 expressi

295 us in development and leukemia, we created a knock-in mouse with a C-terminal truncation by introduci

296 Using a knock-in mouse with a mutated ERalpha eliminating bindin

297 ycan in the aetiology of DMD, we generated a knock-in mouse with a phenylalanine substitution at a ke

298 Herein, we generated a knock-in mouse with a targeted mutation in the immunorec

299 in IL-7-mediated B cell development using a knock-in mouse with a Tyr to Phe mutation (IL-7Ralpha(44

300 We have generated a novel MeCP2 mutant knock-in mouse with the mutation R168X, one of the most