ライフサイエンスコーパス: knock-out

1 ith real scRNA-seq data upon CRISPR-mediated knock-out.

2 was validated by a CRISPR/Cas9 mediated ZnT8 knock-out.

3 hen the endogenous TCR of CD8pos T cells was knocked out.

4 ct was greatest when PspA and PspC were both knocked out.

5 site was knocked in and the N356-glycan site knocked out.

6 which endogenous PS1, PS2, or both have been knocked out.

7 were observed when the processing domain was knocked out.

8 ent haematopoietic progenitors (Hoxb8-FL) to knock out 39 transcription factors (TFs) followed by RNA

9 Furthermore, we show that knocking out a single miRNA, miR-673, restores the antiv

10 al bacterial community of adenylyl cyclase 5 knock-out (AC5KO, n = 7) mice or their wild-type (WT, n

11 We find that knocking out AGO1, AGO2 and AGO3 together are necessary

12 By CRISPR/Cas9 genome editing, we knocked out AH1 and saw that only necroptotic CT26 cells

13 s down-regulated without RORbeta, and Thsd7a knock-out alone disrupts TCA organization in adult barre

14 Knock out also reduces MYC and IRF4 expression.

15 hesis of any metabolite can be interactively knocked-out, analyzed and visualized as a spanning tree,

16 zes next-generation sequencing data for both knock-out and multiple user-specified knock-in modificat

17 Using betaCA3 knock-out and over-expression plants, we demonstrate tha

18 TD) as well as in the wild-type mice and tau knock-out and P301L tau mouse models.

19 s reduced when secondary class B PpCESAs are knocked out and vice versa, as expected for genes encodi

20 hPXR in HepaRG cell lines even when hCAR is knocked out; and 7) activates hPXR in primary human hepa

21 Importantly, the Otx2 conditional knock-out animals used in this study might represent a n

22 In contrast to RanBP9 constitutive knock-out animals, RanBP9-TT mice are viable, fertile an

23 oson in MYB10 that truncates the protein and knocks out anthocyanin biosynthesis in a white-fruited F

24 his modified technology should be useful for knocking out any viral genes from a genome to dissect fu

25 hagy in the retina using a mouse conditional knock-out approach disturbs retino-collicular map format

26 ervations suggest a model wherein TYROBP-KO-(knock-out)-associated reduction in C1q is associated wit

27 Replaying OC43 evolution, we knocked out BCoV HE lectin function and performed forced

28 Knocking out beta6 (beta6 KO) resulted in improved survi

29 In SIRT3 knock-out bone marrow-derived macrophages, NLRP3 activat

30 obvious effect on plant embryo development, knocking out both resulted in severe defects in embryo p

31 ting receptor HRH1 and inhibitory SSTR1 were knocked out by CRISPR, HRH1 knockout (KO) significantly

32 activate transcription from Zp when p53 was knocked out by CRISPR-Cas9.

33 hawytscha) cell line, GS2, with a stat2 gene knocked out by CRISPR/Cas9 genome editing.

34 FLG and DST were knocked out by CRISPR/Cas9 in human DM93 and murine B16-

35 te knockout lines each with a single IR-gene knocked out by lentivirus-mediated CRISPR (clustered reg

36 Dusp1 gene knock-out caused premature progressive hearing loss, as

37 Using CRISPR to knock out CD21, we demonstrated that CD21 is necessary f

38 Finally, using a TMEM106B HeLa knock-out cell line and primary cultured oligodendrocyte

39 HA2 for staphylococcal infection in an EPHA2-knock-out cell line.

40 ady state levels of mRNA in wild-type versus knock out cells, including the strongest cluster within

41 ting in 4-fold lower PPARgamma expression in knock-out cells than in wild-type cells.

42 vation induced differentiation capability of knock-out cells was impaired, owing to the inability to

43 y reduced markers of Warburg effect in ADPGK knock-out cells, finally leading to apoptosis.

44 accumulated mutations in translocated MYC in knock-out cells, signifying a successful targeting of th

45 oyed a tamoxifen inducible BACE1 conditional Knock-out (cKO) mouse model to achieve a controlled part

46 neered a mouse wherein Smc5 is conditionally knocked out (cKO) in the developing neocortex.

47 Further, DYRK1A knock out conferred resistance to ionizing radiation in

48 t in sulfatide (cerebroside sulfotransferase knock-out, CST (-/-)) or complex gangliosides (beta-1,4-

49 We used a cyclin D2-knock-out (cyclin D2(-/-)) mouse model of endogenously d

50 ish to create a diagnostic-compatible triple knock-out DeltaBCG TK strain.

51 in RNA (shRNA) or in which the gene had been knocked out (DeltaGADD45gamma) yielded significantly les

52 n which the gene encoding hnRNPA2B1 has been knocked out (DeltahnRNPA2B1 cells) was reduced 3-fold.

53 le Depdc5 knockout mouse, hypothesizing that knocking out Depdc5 in muscle would make mTORC1 constitu

54 Using a flagellin knock-out derivative and purified recombinant protein, M

55 In this way, empirical knock-out distributions are extracted and both the shake

56 ons are extracted and both the shake-off and knock-out distributions are parametrized.

57 5-HT in vesicle-like structures, and ERICH3 knock-out dramatically decreased 5-HT staining in SK-N-S

58 with Thap1 (C54Y/+) knock-in and Gnal (+/-) knock-out dystonia models and to determine the impact of

59 during elongation, whereas knocking down or knocking out eEF2K increases their frequency.

60 brain functional connectivity in Engrailed-2 knock-out (En2 (-/-)) adult mice, which show a lower exp

61 Mouse Phenotyping Consortium (IMPC) aims to knock out every gene in the mouse and comprehensively ph

62 We began by generating mice that were knocked out for Srsf6, and demonstrated that reduction o

63 Knocking out Fth produced the most severe phenotype, fol

64 beta-1,4-N-acetylegalactosaminyltransferase1 knock-out, GalNAc-T (-/-)) display prominent disorganiza

65 ned these into a single cohesive strategy to knock out gene function.

66 Here, we use CRISPR base editors to knock out genes by changing single nucleotides to create

67 ommensal organism Clostridium sporogenes, we knocked out genes for 10 C. sporogenes-derived molecules

68 dic protein (GFAP) promoter-driven aromatase knock-out (GFAP-ARO-KO) mouse model to deplete astrocyte

69 dic protein (GFAP) promoter-driven aromatase knock-out (GFAP-ARO-KO) mouse to deplete astrocyte-deriv

70 very of Cas9 mRNA and sgRNA using BAMEA-O16B knocks out green fluorescent protein (GFP) expression of

71 In mice, knocking out Gsdme in GSDME-expressing tumours enhances,

72 Our goal was to knock out Gys1 in laforin (Epm2a)-deficient LD mice afte

73 The STAT2 knock-out hamster model of CCHFV infection may provide s

74 In this study, we show how knocking out HB-EGF expression in CD4 T cells in vivo at

75 Knocking out HB-EGF in CD4 T cells resulted in increased

76 essed by creating a heterozygous conditional knock out (het CKO) murine model with central nervous sy

77 d heterozygous ACTL6B mutations on an ACTL6B knock-out human background demonstrated that bi-allelic

78 CRISPR/Cas9 was used for beta2M knock out in JE6-1(REP-iNKT) cells to abrogate CD1d expr

79 one-mediated demyelination, showed that PAR1 knock-out in male mice improves replenishment of myelina

80 ostacyclin levels were reduced when COX1 was knocked out in ECs but not in smooth muscle cells.

81 lls retain HR activity, the UBE2T genes were knocked out in HeLa cells and U2OS cells.

82 ssed in human fetal cardiac tissue, and when knocked out in human induced pluripotent stem cell deriv

83 DNMT3A was knocked out in human induced pluripotent stem cells by C

84 To test these hypotheses, Cyp26a1 was knocked out in juvenile and adult male and female Cyp26a

85 Mice with Vegf-A conditionally knocked out in macrophages (Vegf-A(fl/fl); LysM(Cre) mic

86 Fan1 knock-out increased somatic expansion of Htt CAG repeats

87 he Htt knock-in CAG repeat, blocked the Fan1 knock-out-induced acceleration of somatic CAG expansion.

88 lian cellular phosphate homeostasis, here we knocked out inositol hexakisphosphate kinase (IP6K) 1 an

89 Knocking out integrin beta6 in obese mice favorably alte

90 nergic agonists reacidify lysosomes in PSEN1 Knock out (KO) cells and fibroblasts from PSEN1 familial

91 o C57BL/6 or high alloantibody-producing CD8 knock out (KO) hepatocyte transplant recipients.

92 invasion were delayed in only the PVPV-Akt1 knock out (KO) mice in association with increased apopto

93 te intensive preclinical research using Fmr1 knock out (KO) mice, an effective treatment for FXS has

94 RC1 in haemopoietic lineage commitment using knock out (KO) mouse and cell line models.

95 We used CRISPR-Cas9 targeted mutagenesis to knock out (KO) the MsexOrco gene to test the consequence

96 of the AtNBR1 gene (OX lines) and the AtNBR1 Knock-Out (KO lines).

97 ne-specific antibodies revealed that FAM173A knock-out (KO) abrogates lysine methylation of a single

98 Here we report that male mice knock-out (KO) for Ophn1 display hippocampal epileptifor

99 Here we show that FLCN Knock-out (KO) hESCs maintain the naive pluripotent stat

100 Ptchd1 knock-out (KO) male mice exhibit cognitive alterations,

101 beta4 knock-out (KO) male mice show increased novelty-induced

102 To address this issue, we used Ca(V)3.3 knock-out (KO) mice and a panselective T-channel blocker

103 rtical neurons from wild-type (WT) and HCAR1 knock-out (KO) mice from both sexes.

104 Schwann cells and nerves from PMP22 knock-out (KO) mice show deranged cholesterol distributi

105 However, recent evidence from PKMzeta-knock-out (KO) mice suggests that ZIP may function throu

106 ild-type and amyloid precursor protein (APP) knock-out (KO) mice to assess the effects of Abetaos on

107 We therefore expect Cirbp knock-out (KO) mice to exhibit attenuated sleep-deprivat

108 male constitutive and conditional Arc/Arg3.1 knock-out (KO) mice to investigate the causal relationsh

109 12- to 14-week-old TLR2, TLR4, TLR2/4 double knock-out (KO) mice using a MiSeq platform targeting the

110 rioles from wild type (WT) and SMTNL1 global knock-out (KO) mice were examined with pressure myograph

111 aging data from somatosensory cortex of Fmr1 knock-out (KO) mice, a model of Fragile-X Syndrome, to t

112 In aralar-knock-out (KO) mice, betaOHB recovers from the drastic d

113 Using both sexes of H1a knock-out (KO) mice, we found that there is basal reduct

114 function in a mouse model of autism, Shank3b knock-out (KO) mice.

115 xcitability of CA3 pyramidal neurons in Fmr1 knock-out (KO) mice.

116 ynaptic function in male and female Cacna2d2 knock-out (KO) mice.

117 servation of deleterious phenotypes in BACE1 Knock-out (KO) mouse models (germline and conditional) r

118 al phenotype in the FXS mouse model-the Fmr1 knock-out (KO) mouse.

119 The resulting At2OGO knock-out (KO) mutants display enhanced resistance to Fg

120 enic diet (KD), is neuroprotective in aralar-knock-out (KO) neurons and mice.

121 ogies have enabled production of target-gene knock-out (KO) NHP models.

122 ulations involved, we demonstrated here that knock-out (KO) of mGluR5 in cholinergic, but not glutama

123 validation of EGR 1 gene was accomplished by knocking out (KO) of EGR 1 in cultured luteal cells by C

124 e expression, RNA interference, knock-in and knock-out, lack sufficient spatiotemporal accuracy, whil

125 Knocking out Larp4 in mice destabilized Nfkappab1 mRNAs

126 ppears to be indispensable, given that Atad5 knock-out leads to embryonic lethality.

127 showing large accuracy when compared with a knock-out library and Bar-seq data; and (iv) allowed map

128 e construct the smallest whole-genome CRISPR knock-out library, Mini-human, for the human genome (n =

129 by pigment presence or absence (wild-type or knock-out lineages, respectively) followed a strict oral

130 s in pools of mutants compared to homogenous knock-out lines of the key virulence factor MYR1.

131 induced cardiac remodeling, we subjected LUM knock-out (LUMKO) mice to aortic banding (AB) and treate

132 , both WT and Ca(v)3.1(-/-); 3.2(-/-) double knock-out lymphatic vessels responded similarly to mibef

133 We found that PRMT1 knock-out macrophages failed to up-regulate PPARgamma ex

134 Lastly, knocking out MCPIP1 attenuated the anti-HBV effect of IL

135 We evaluated the importance of knocking-out mGluR5 in three different cell types in two

136 selective inhibitor TP-10, and global PDE10A knock out mice were used.

137 idea in a more definitive way using genetic knock out mice.

138 for the PON1 human transgene [PON1Tg], PON1 knock-out mice [PON1KO], and wild type littermate contro

139 Fmr1 knock-out mice also show reduced functional connectivity

140 ng of ryanodine receptors using synaptopodin-knock-out mice ameliorates AD symptoms at the behavioral

141 This project identified Fam151b homozygous knock-out mice as having retinal degeneration.

142 LTD was absent in CB1 knock-out mice but preserved in heterozygous littermates

143 ysis of the retinal microvasculature in ORP2 knock-out mice generated during this study demonstrates

144 Improvements in myelin regeneration in PAR1 knock-out mice occurred in tandem with a skewing of reac

145 rom compound-transgenic wild-type and Chrna5 knock-out mice of both sexes.

146 ongly suggest that the hearing loss of BACE1 knock-out mice represents a developmental phenotype.SIGN

147 in the corneal surface of Piezo2 conditional knock-out mice revealed a reduced number of mechano-sens

148 Similarly, alpha-synuclein knock-out mice show increased neuronal DSBs that can be

149 Conversely, cochleae from Sema5b knock-out mice showed type I SGNs with more numerous, bu

150 yte-specific furin, PC5/6, or complete PACE4 knock-out mice suggested that the cleavage of overexpres

151 ene is unknown, embryonic lethality in Mrpl3 knock-out mice suggests it is critical for early develop

152 In astrocyte-specific Cx43 knock-out mice the magnitude of heart rate responses to

153 in the corpus callosum and cortex of Cav1.2 knock-out mice through demyelination.

154 Adiponectin knock-out mice were orally administered dextran sulfate

155 Immunodeficient RAG2 knock-out mice were unable to control infection with TDP

156 We have generated Thap1 knock-out mice with a view to understanding its transcri

157 Daily treatment of adult male fmr1 C57Bl6 knock-out mice with BPN14770 for 14 days reduced hyperar

158 Finally, we crossed EP3R conditional knock-out mice with either VGluT2-IRES-cre or Vgat-IRES-

159 Knock-out mice without functional mGluR5 exhibit severe

160 Using these vectors, we vaccinated STAT-1 knock-out mice, an animal model for CCHFV.

161 Using a combination of PAR1 knock-out mice, oligodendrocyte monocultures and oligode

162 rrel cortex activity in young and adult Fmr1 knock-out mice, the mouse model of fragile X syndrome (F

163 By using Piezo2 conditional knock-out mice, we show that Piezo2 channels, present in

164 AR potentials in slices from serine racemase knock-out mice, which are devoid of D-serine, indicating

165 on of YAP rescues cardiac defects in Xinbeta knock-out mice-indicating a functional and genetic inter

166 ced direct propriospinal excitation in EphA4 knock-out mice.

167 igomerization-deficient mutant in arrestin-1 knock-out mice.

168 er, most studies were performed using single knock-out mice.

169 nd memory, in contrast with heterozygous NGF knock-out mice.

170 erebellum internal feedback pathway in EphA4 knock-out mice.

171 wild-type and Ca(v)3.1(-/-); 3.2(-/-) double knock-out mice.

172 Here, we tested this hypothesis using triple-knock-out mice.

173 -immunity, we generated T-cell-specific Atg5 knock-out mice.

174 F-NB1 was validated in wild-type and sigma1R knock-out mice.

175 By using SCF conditionally knocked out mice, we demonstrated that keratinocytes' au

176 We found that EphA4 knock-out (-/-) mice displayed impaired goal-directed re

177 alpha, unanticipated based on alpha-neurexin knock-out models, in controlling presynaptic morphology

178 ion in DHA-deprived retinas using the Mfsd2a knock-out mouse as animal model.

179 solution microscopy were performed in prkar1 knock-out mouse embryonic fibroblasts, neonatal myocytes

180 ation, we generated an inducible conditional knock-out mouse in which the Cav1.2 alpha subunit was de

181 hed and a number of animal models, including knock-out mouse lines, have been developed that mirror d

182 We developed a new Formin-like-1 (FMNL1) knock-out mouse model and determined that the cytoskelet

183 analyzed brain structure in a maternal Ube3a knock-out mouse model of AS.

184 e animal models such as the apolipoprotein E knock-out mouse model of atherosclerosis, suggest greate

185 te in a newly generated Tmem106b CRISPR/cas9 knock-out mouse model.

186 igration whereas subsequent work with double knock-out mouse models for both Kiaa0319 and its paralog

187 This astrocytic Cav1.2 knock-out mouse was tested in the cuprizone model of mye

188 c allele compared to a new loss-of-function (knock-out) mouse model.

189 he abundance of 307 proteins between a deg1c knock-out mutant and the wild type under nonstress condi

190 The triple nmt1 nmt2 nmt3 knock-out mutant cannot synthesize PC from PEA and is le

191 However, the double nmt1 nmt3 knock-out mutant is viable.

192 A nuclear localization signal (NLS) knock-out mutant N did not activate NF-kappaB, and this

193 of them were further studied by phenotyping knock-out mutant plants.

194 /-) is a genetically engineered centrin gene knock-out mutant strain that is antibiotic resistant mar

195 d local lesions in genomes, of a tomato cry2 knock-out mutant, its introgression in the indeterminate

196 DRT111 knock-out mutants are defective in ABA-induced stomatal

197 ims using Arabidopsis (Arabidopsis thaliana) knock-out mutants lacking either phot2 or chup1 and anal

198 A splicing of flowering-related genes in the knock-out mutants of AtU2AF65b.

199 Knock-out mutants of DAD1 or DAD2 exhibited the opposite

200 BbThm1 gene knock-out mutants showed severely impaired growth/resist

201 We found that knocking out MyD88 in the donor T cells protected agains

202 wild-type (n = 23) and myeloperoxidase (MPO) knock-out (n = 5) mice were infected with the Plasmodium

203 as knocking down the MIA40 oxidoreductase or knocking out NDUFA11 protein.

204 ostasis in Arc knock-out neurons, as well as knock-out neurons lacking the activity-regulated transcr

205 EPSCs in wild-type neurons, but not in Nlgn1 knock-out neurons or when endogenous Nlgn1 was replaced

206 Overexpression of Doc2b variants in triple-knock-out neurons reduced spontaneous release but did no

207 cing wild-type and mutant proteins in triple-knock-out neurons, and conclude that the sensors are hig

208 , we observed firing rate homeostasis in Arc knock-out neurons, as well as knock-out neurons lacking

209 Knocking out NO66 increased the enrichment of H3K4me3 an

210 Knocking out Nox4 in skeletal muscles or pharmacological

211 Genetic knock out of Bmal1 and over-expression or activation of

212 CRISPR knock out of MEF2C and IRF4 significantly reduces MYC an

213 h iNs, we demonstrated that the heterozygous knock out of SCN2A, whose loss-of-function mutation is s

214 Moreover, we found that knock out of the endonuclease METHYL METHANESULFONATE AN

215 Engineered knock-out of ACTL6B in wild-type human neurons resulted

216 Finally, conditional knock-out of Cav1.2 in dopamine D1 receptor (D1R)-expres

217 dress this question, we crossed mice-bearing knock-out of Klf9, an ubiquitous transcriptional regulat

218 , we find that the selective and conditional knock-out of mGluR5 signaling from astrocytes during epi

219 Knock-out of microRNA was achieved by CRISPR-CAS9 in CCL

220 Simultaneous knock-out of Mlh1, the ortholog of a third HD age-at-ons

221 Knock-out of omega1 and the diminished levels of these c

222 nile- and the adult-onset HD ranges, whereas knock-out of Rrm2b did not greatly alter somatic Htt CAG

223 using both sexes of mouse that acute genetic knock-out of the obligatory subunit of NMDAR or acute ph

224 We recently discovered that global knock-out of the thrombin receptor, also known as Protea

225 Through time-dependent conditional knock-out of Unc-4, we found that its function is requir

226 dgehog pathway either by CRISPR mediated SHH knock out or GANT61 altered regulation of EMT markers in

227 egies are presented that make it possible to knock out or modulate through activation and repression.

228 f coagulation factor XII (FXII), because its knock-out or inhibition in animals reduced thrombosis wi

229 uring M. oryzae infection or when Bsr-d1 was knocked out or downregulated, as occurs in bsr-d1 plants

230 phenotypes could be reproduced or rescued by knocking out or restoring BMAL1 exclusively in skeletal

231 HeLa cells in which both variants were knocked out (ORP1-null) were used to determine the funct

232 Here we demonstrate that knocking out PAR1 also promotes myelin regeneration.

233 veals a potential trans-rescue of individual knock-out parasites in pools of mutants compared to homo

234 factors and we confirm results using cloned knock-out parasites.

235 distributions representing the shake-off and knock-out parts by simulating the sharing distribution c

236 photoreceptor-specific inducible conditional knock-out (Pde6g-Cre(ERT2)) of ARL13B using murine model

237 Intriguingly, knocking out peptidylarginine deiminase 4 (PAD4, a key e

238 naling among paralogous receptors and common knock-out phenotypes of ligand-receptor pairs, relations

239 old sensitivity and ribosome assembly defect knock-out phenotypes.

240 ous LPAT activity to relieve competition and knocked out phosphatidylcholine:diacylglycerol cholineph

241 M3K triple knock-out plants show reduced ABA sensitivity and strong

242 roaches of overexpressing, knocking down, or knocking out PP2A regulatory subunits have yielded only

243 However, KP mice harboring conditional knock out Prkci alleles (KPI mice) develop LADC tumors t

244 ry human TM cells and human, bovine, and PrP-knock-out (PrP(-/-)) mouse models, we demonstrate that P

245 We knocked out Rag1, Rag2, and Il2rg in Sprague Dawley (SD)

246 We now report ADPGK knock-out Ramos BL cells display abated in vitro and in

247 reased MAOA expression while CRISPR-mediated knock out resulted in elevated MAOA expression.

248 to visualize SWEET protein accumulation and knock-out rice lines to identify virulence mechanisms in

249 function relevant to OCD, we used the Sapap3 knock-out (Sapap3-KO) mouse model of compulsive behavior

250 ects caused by the depletion of globulins in knock-out seeds.

251 r knock-out zebrafish in either wild-type or knock-out shoals and tested different components of soci

252 Here, we show, by systematically knocking out single and multiple non-core subunits of th

253 then opened holes elsewhere on the trimer by knocking out single N-linked glycans at residues 197, 23

254 ed photoreceptors, we generated a pan-retina knock-out (Six3-Cre) and a rod photoreceptor-specific in

255 tial clock genes such as Bmal1 and Per1 were knocked out so efficiently that functional assays could

256 ate locomotion through a genetic approach by knocking out somatostatin 1.1 (sst1.1) in zebrafish.

257 We conclude that knocking out SR-B1 in prostate cancer tumors reduces HDL

258 n this study, we report that female stathmin knock-out (STM KO) mice are unable to nurse their litter

259 aining different levels of CfrA, including a knock-out strain (DeltacfrA), and two strains overexpres

260 ing a panel of recombinant TbD1-knock-in and knock-out strains and comparison with clinical isolates,

261 ts in Caenorhabditis elegans osm-9 and tax-4 knock-out strains.

262 Here, we used cell-type-specific conditional knock-out strategies to alter mTORC1 function selectivel

263 Knocking out Ta7ANPR1 enhanced resistance to stem rust.

264 Knocking out TDO in squid embryos efficiently eliminated

265 Here, we used gene editing by CRISPR-Cas9 to knock out the oncogene p53 in dog oviductal epithelia cu

266 hat CRISPR/Cas9 technology can be applied to knock out the ORF57 gene from all ~100 copies of the KSH

267 We knocked out the Fndc5 gene to generate irisin-lacking mi

268 Thus, we knocked out the main de novo DNA methyltransferase in ca

269 We knocked out the transcription factor Satb2 in PNs to ind

270 genes in the mouse cochlea and the impact of knocking out the Bhmt gene in the auditory receptor.

271 cted EBV-LMP2-specific TCRs was optimized by knocking out the endogenous TCR of primary T cells (Delt

272 cally inhibiting actin polymerization and by knocking out the forked gene in the mosquito (Ae-Forked;

273 By knocking out the Lhcx1 and Lhcx2 genes individually in P

274 crease in intracellular cAMP persisted after knocking out the NMDA receptor indicating an NMDA recept

275 ious effect on in vivo tumor growth, whereas knocking out the nonpreferred pathway has a lesser effec

276 CRISPR/Cas9 technology was very efficient in knocking out the ORF57 gene in iSLK/Bac16 and HEK293/Bac

277 Knocking out the preferred nucleotide pathway in each su

278 By knocking out the secreted WNT inhibitors active in our s

279 ill pathogens with specific DNA sequences or knock out their antibiotic resistance genes using CRISPR

280 Knocking out these genes in mammalian airway epithelial

281 By knocking out these genes, the engineered CHO cells exhib

282 Here we report that knocking out these three factors markedly extends surviv

283 Here we knocked out three different genes thought to be involved

284 essential role in differentiation, a triple knock-out (tKO) of the three genes has not been done to

285 Knocking out TREM2 in 5xFAD mice exacerbated Abeta patho

286 spaced short palindromic repeats (CRISPR) to knock out two key genes (feminizer and doublesex) that g

287 Knocking out Ube2v1 exclusively in cardiomyocytes by usi

288 The BMPR-IB gene was knocked out using CRISPR-Cas technology in granulosa cel

289 osarcoma cells in which the MT1-MMP gene was knocked out using CRISPR/Cas9.

290 that leverages the transgenic, knock-in, and knock-out variants of mouse models of human disease requ

291 -like (dal) mouse, in which the prolidase is knocked-out, was used to investigate whether the deficie

292 To investigate this in vivo, we knocked out WAVE1 and WAVE2 genes, individually and toge

293 tion of branched short-chain fatty acids was knocked out, we discovered that these microbial products

294 Male mice in which Nell2 had been knocked out were infertile.

295 ISPR) screen that a total of 273 genes, when knocked out, will lead to sustained NRF2 activation.

296 TFG depletion with siRNA, or knock-out with CRISPR/Cas9, significantly reduced Wnt/be

297 dA DNA levels in embryos developed from MTH1 knock-out zebrafish eggs microinjected with N6-methyl-dA

298 or this purpose, we have raised wild-type or knock-out zebrafish in either wild-type or knock-out sho

299 animal model for partial MYLPF impairment by knocking out zebrafish mylpfa.

300 We previously demonstrated that knocking out ZNF274, a Kruppel-associated box-A-domain z