ライフサイエンスコーパス: knock-out mouse

1 educed in a phospholipase C beta1 (PLCbeta1) knock-out mouse.

2 ha into injured nerves in the TNF-alpha gene knock-out mouse.

3 lls, we established a T-cell-specific S1P(1) knock-out mouse.

4 bly of receptor subunits, we studied a GluR2 knock-out mouse.

5 ons in locomotion and pain perception in the knock-out mouse.

6 zure protection was maintained in the Asic1a knock-out mouse.

7 pecific manner in an inducible, EC-specific, knock-out mouse.

8 d by the unique phenotypes for each TGF-beta knock-out mouse.

9 tibody against MT1-MMP, raised in an MT1-MMP knock-out mouse.

10 ophrenia, the forebrain-specific calcineurin knock-out mouse.

11 is occluded in neurons generated from PICK1 knock-out mouse.

12 ly spliced CFTR mRNA is produced in this CF 'knock-out' mouse.

13 The Fmr1 knock-out mouse, a model of fragile X syndrome, exhibits

14 address this question, we generated an AEG-1 knock-out mouse (AEG-1KO) and characterized it.

15 In addition, the mu-opioid receptor knock-out mouse also shows increases in striatal zinc pa

16 In the ephrinB3 knock-out mouse, although spine synapses are normal, sha

17 We created an ErbB4-JMa specific knock out mouse and demonstrate that RIP-dependent, non-

18 erated an intestinal epithelium-specific Raf knock-out mouse and identified Raf kinase as a key regul

19 ology, we used Sp1 siRNA, a heterozygous Sp1 knock-out mouse, and mithramycin A, a DNA-intercalating

20 ion in DHA-deprived retinas using the Mfsd2a knock-out mouse as animal model.

21 % loss of [Ca(2+)]i responsiveness in betaAR knock-out mouse ASM.

22 s their expression in other brain regions of knock-out mouse brain was the same as wild type.

23 CaR was increased in lysates from GABA-B-R1 knock-out mouse brains and in cultured hippocampal neuro

24 c-8b in vivo, we generated a tissue specific knock-out mouse by crossing OMP-Cre transgenic mice to R

25 The TLR11 knock-out mouse can serve as a good animal model to stud

26 nthesis was markedly attenuated in the LOX-1 knock-out mouse cardiac fibroblasts as well as in WT mou

27 as overexpressed in wild-type (WT) and LOX-1 knock-out mouse cardiac fibroblasts by transfection with

28 ossed the BACHD mouse model with a caspase-6 knock-out mouse (Casp6(-/-)).

29 In CNP-Cre;Cdk5(fl/fl) conditional knock-out mouse (Cdk5 cKO), myelin repair was delayed si

30 More importantly, E6AP knock-out mouse cells and small interfering RNA techniqu

31 Adiponectin knock-out mouse colons had markedly reduced proliferatio

32 vents that were attenuated in the caveolin-1 knock-out mouse confirming a role for CEMs in ROS genera

33 ong-term depression occurred in the mGluR(4) knock-out mouse, consistent with its postsynaptic origin

34 2AX was markedly suppressed in the Plk3(-/-) knock-out mouse corneal epithelial layer in response to

35 have generated a T cell-specific Coronin 1a knock-out mouse (Coro1a(fl/fl) x Cd4[Cre]).

36 and the visual blind cone-rod homeobox gene knock out mouse (Crx(-/-) ) with degeneration of the ret

37 Here, we describe a knock-out mouse deficient in selenoprotein MsrB1, the ma

38 ioenergetics are blunted in insulin receptor knock-out mouse-derived skeletal myoblasts.

39 The ARC knock-out mouse developed larger infarct in response to

40 The hepatocyte-specific Hnf4a knock-out mouse develops severe hepatomegaly and steatos

41 However, only in the total receptor knock-out mouse do we see the decreases in serum ferriti

42 inhibited proliferation in both LKB and LKB knock-out mouse embryo fibroblasts to similar extent and

43 ted apoptosis in TNF-alpha-treated caspase-9 knock-out mouse embryo fibroblasts.

44 ChIP-seq and ATAC-seq analyses using KAP1 knock out mouse embryonic stem cells expressing wild typ

45 apoptosis induction in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells (MEF-Akt1,2-D

46 VDAC3 knock-out but not VDAC1 and -3 double knock-out mouse embryonic fibroblast cells, confirming t

47 hat when compared with wild-type cells, PTEN knock-out mouse embryonic fibroblasts (PTEN KO MEF) have

48 Triple knock-out mouse embryonic fibroblasts (TKO MEFs) had a s

49 r77 transfection into RXRalpha wild-type and knock-out mouse embryonic fibroblasts and subsequent tre

50 Using both top2beta knock-out mouse embryonic fibroblasts and Top2beta small

51 Correspondingly, Nelf-b knock-out mouse embryonic fibroblasts exhibited slower p

52 LOX knock-out mouse embryonic fibroblasts mirrored the effec

53 ctional connections, we found by using STAT3 knock-out mouse embryonic fibroblasts that RhoA, Rac1, a

54 We now generated kazrin knock-out mouse embryonic fibroblasts to investigate its

55 l responses are enhanced in Spry1,2,4 triple knock-out mouse embryonic fibroblasts, consistent with n

56 solution microscopy were performed in prkar1 knock-out mouse embryonic fibroblasts, neonatal myocytes

57 solution microscopy were performed in prkar1 knock-out mouse embryonic fibroblasts, neonatal myocytes

58 ased using small interfering RNA and in Msk1 knock-out mouse embryonic fibroblasts, suggesting that t

59 In wild type and FAK knock-out mouse embryonic fibroblasts, we found by immun

60 In G(s) knock-out mouse embryonic fibroblasts, wild-type beta2AR

61 is readily internalized in beta-arrestin1/2 knock-out mouse embryonic fibroblasts.

62 cardiomyocytes cultured from homozygous jmj knock-out mouse embryos (jmj mutants) show increased cel

63 Slice preparations from D1 or D2 receptor knock-out mouse embryos confirm the findings.

64 n the cerebral wall of the dopamine receptor knock-out mouse embryos further confirmed the effects of

65 MEFs derived from LCMT-1 knock-out mouse embryos have reduced levels of PP2A B re

66 Previous studies of knock-out mouse embryos have shown that the Wilms' tumor

67 ectroporated with FMRP small hairpin RNA and knock-out mouse embryos lacking FMRP reveals that specif

68 Characterization using PS-1 knock-out mouse embryos revealed 50 and 80% reductions o

69 Using gene knock-out mouse ESCs, we studied the roles of MKK4 and M

70 Furthermore, we generated a conditional knock-out mouse for ERp57 in the nervous system and dete

71 ation and myelination, we used a conditional knock-out mouse for voltage-operated Ca(2+) channels in

72 hermore, since production of a transgenic or knock-out mouse frequently requires cross-breeding, care

73 By using a galectin-3 knock-out mouse (Gal-3KO), we demonstrated that targeted

74 al in the Esm1 wild-type but not in the Esm1 knock-out mouse GBM model.

75 We analyzed nearly 3900 individually knocked out mouse genes and discovered that the proporti

76 her characterize this region, we generated a knock-out mouse (GREKO(-/-)) with a deletion of the mGnR

77 The FXS animal model, the Fmr1 knock-out mouse, has demonstrated an increased mGluR5-me

78 receptor number and synapse function in xCT knock-out mouse hippocampal CA3-CA1 synapses.

79 These changes are observed in Kv4.2 knock-out mouse hippocampal neurons, which are also sens

80 amined its processing in PC2, 7B2, and PC1/3 knock-out mouse hypothalamic extracts and demonstrated t

81 onal activation in the wild-type (WT) and OT knock-out mouse in olfactory bulbs, piriform cortex, cor

82 ls in the forebrains of the Dlx1/Dlx2 double knock-out mouse in vivo Identification of Gad genes as d

83 n, we took advantage of a unique conditional knock-out mouse in which Lmx1b is genetically deleted in

84 ation, we generated an inducible conditional knock-out mouse in which the Cav1.2 alpha subunit was de

85 ation, we generated an inducible conditional knock-out mouse in which the L-VGCC isoform Cav1.2 was d

86 pment, we generated an inducible conditional knock-out mouse in which the L-VOCC isoform Cav1.2 was p

87 dies, using a novel Casr intestinal-specific knock-out mouse, indicate that the genetic ablation of t

88 In a conditional knock-out mouse, induced LIS1 deficiency in adulthood al

89 The Kir4.1 knock-out mouse is one of the few CNS dysmyelinating or

90 oss of collecting duct P2Y2 receptors in the knock-out mouse is the primary defect leading to increas

91 The knock-out mouse is virtually devoid of AChE activity and

92 nced by interacting proteins, we generated a knock-out mouse lacking the HCN channel auxiliary subuni

93 hannels in the corpus cavernosum utilizing a knock-out mouse lacking the Slo gene (Slo-/-) responsibl

94 Further, we used a conditional knock-out mouse lacking vesicular glutamate transporter

95 ential roles of PMP22, we engineered a novel knock-out (-/-) mouse line by replacing the first two co

96 rated an inducible, cell type-specific Ift88 knock-out mouse line (K5rtTA;tetOCre;Ift88(fl/fl)) to di

97 cultures, a postsynaptic density-95 (PSD-95) knock-out mouse line and electrophysiological analysis,

98 this study, we generated a conditional gene knock-out mouse line to specifically nullify Ggamma13 ex

99 We previously generated a conditional Pten knock-out mouse line with Pten loss in limited postmitot

100 c and excitatory neuron-specific conditional knock-out mouse line, and demonstrated that Dab1 is a cr

101 erated a forebrain-specific conditional TrkA knock-out mouse line.

102 hed and a number of animal models, including knock-out mouse lines, have been developed that mirror d

103 Utilizing knock-out mouse lines, we identified BDNF and tyrosine r

104 protein expression was near normal in PDZK1 knock-out mouse liver.

105 at Fgf21 expression is up-regulated in E4bp4 knock-out mouse liver.

106 unction of TET2 in vivo, we generated a Tet2 knock out mouse model.

107 ddress this, we use a biliverdin reductase-A knock-out mouse model (Blvra(-/-)), which elevates endog

108 se of a conditional, hepatocyte-targeted AHR knock-out mouse model (Cre(Alb)Ahr(Fx/Fx)).

109 Here, we developed a new Cx30 knock-out mouse model (Cx30(Delta/Delta)) in which half

110 Using a myeloid-specific HuR knock-out mouse model (Elavl1Mo KO), we show that HuR ex

111 s, we conducted experiments using an IP(3)R2 knock-out mouse model (IP(3)R2 KO).

112 athology, we generated a heterozygous Pabpn1 knock-out mouse model (Pabpn1+/Delta).

113 sing a progesterone receptor-cre conditional knock-out mouse model (Tgfbr2(flox/flox);Pgr(cre/+); "Tg

114 We developed a new Formin-like-1 (FMNL1) knock-out mouse model and determined that the cytoskelet

115 We developed and characterized a conditional knock-out mouse model and found that GSKIP deficiency ca

116 We generated a conditional SNX4 knock-out mouse model and report that SNX4 cKO synapses

117 own to ameliorate mitochondrial disease in a knock-out mouse model lacking a nuclear-encoded gene spe

118 analyzed brain structure in a maternal Ube3a knock-out mouse model of AS.

119 e animal models such as the apolipoprotein E knock-out mouse model of atherosclerosis, suggest greate

120 The Fmr1 knock-out mouse model of fragile X syndrome (Fmr1(-/y))

121 We explored retinal function in the Fmr1 knock-out mouse model of FXS.

122 To address in vivo function, we generated a knock-out mouse model of G2E3 deficiency that incorporat

123 romotes "off-target" tumorigenesis in a MDR2 knock-out mouse model of hepatocellular carcinoma (HCC)

124 Here, using the Mlc1 knock-out mouse model of MLC, we demonstrated that MLC1

125 Whereas the current gene knock-out mouse model of MLII lacks some of the characte

126 u, delta and kappa) and a mu-opioid receptor knock-out mouse model of RLS show circadian motor change

127 function of the NuRD complex, we generated a knock-out mouse model of the Mta2 (metastasis-associated

128 To overcome these issues, an acute Hnf4a knock-out mouse model was generated through use of the t

129 To extend this study in vivo, a Galphaz knock-out mouse model was utilized to determine whether

130 A knock-out mouse model with an Ndp gene disruption was st

131 ell as in a neuron-specific Tsc1 conditional knock-out mouse model, and show differential responses t

132 rage in an in vivo constitutive adipose FIT2 knock-out mouse model, but the physiological effects of

133 JB6 deletion as well as in the previous Cx30 knock-out mouse model, defective Cx26 expression is the

134 Here, we utilized a p47(phox) knock-out mouse model, in which an essential cytosolic c

135 Using an Lzts2 knock-out mouse model, we characterized the biological r

136 By using a knock-out mouse model, we here demonstrate that p140Cap

137 Using a conditional knock-out mouse model, we show that Notch3 receptor acti

138 ses in vivo, we created a cell type-specific knock-out mouse model.

139 Thus, we generated a Slc25a46 knock-out mouse model.

140 e generated a cardiac-specific and inducible knock-out mouse model.

141 nt lymphocytes generated using a conditional knock-out mouse model.

142 by studying an inducible SC-specific Gpr126 knock-out mouse model.

143 te in a newly generated Tmem106b CRISPR/cas9 knock-out mouse model.

144 c allele compared to a new loss-of-function (knock-out) mouse model.

145 es released from proteins of three different knock-out mouse models associated with O-mannosylation (

146 igration whereas subsequent work with double knock-out mouse models for both Kiaa0319 and its paralog

147 mmals by generating and using a range of new knock-out mouse models for the hypusine-modifying enzyme

148 Using conditional knock-out mouse models to delete Ikaros at different loc

149 : Due to the development of numerous genetic knock-out mouse models, the identification of specific r

150 Using complementation assays in knock-out mouse models, we established the contributions

151 fication of key enzymes, as revealed by gene knock-out mouse models.

152 dies and to limitations of existing p75(NTR)-knock-out mouse models.

153 h other ADAMTS proteoglycanase combinatorial knock-out mouse models.

154 Ankyrin-G conditional knock-out mouse myocytes display decreased Nav1.5 expres

155 that genetic inactivation of the 5-HTT in a knock-out mouse not only failed to prevent ethanol-induc

156 cific for ANGPTL4, recapitulated the Angptl4 knock-out (-/-) mouse phenotype of reduced serum TG leve

157 PKG I knock-out mouse platelets and PKG inhibitor-treated huma

158 The AP-2alpha transcription factor knock-out mouse provides an exceptional tool to understa

159 -dominant neural retina leucine zipper (Nrl) knock-out mouse retinas compared with wild type rod-domi

160 der excitotoxic condition, cell loss in Cx45 knock-out mouse retinas was similar to that seen in wild

161 ring by low pHo were maintained in an Asic1a knock-out mouse ruling out this acid-sensing channel as

162 Fibroblasts from Optn knock-out mouse showed reduced LC3-II formation and a lo

163 The Gclm(-/-) knock-out mouse shows tissue levels of GSH that are betw

164 We produced an LRAT gene knock-out mouse strain and assessed whether LRAT-/- mice

165 d in control (C57BL/6) mice and two congenic knock-out mouse strains with deletions of either TRPV1 o

166 eurons in behavior, we generated conditional knock-out mouse strains with the primary protein compone

167 s effect was differentially impaired in both knock-out mouse strains.

168 Pharmacological inhibition and conditional knock-out mouse studies showed that Presenilin 1 and Not

169 Knock-out mouse studies, in combination with pharmacolog

170 Studies in the AFABP/aP2 knock-out mouse suggest that the protein may have roles

171 and in a brain-restricted alpha-dystroglycan knock-out mouse that is similar to that seen in patients

172 In cells from the specific STAT knock-out mouse, the signature cytokine locus is unable

173 AMPA receptors, we have used the GluR2(-/-) knock out mouse to determine whether the expression of m

174 For this purpose, we generated a conditional knock-out mouse to address the functions of the NMDA-R i

175 We generated a knock-out mouse to characterize calsyntenin-1 function i

176 We generated a conditional GLT-1 knock-out mouse to uncover cell-type-specific functional

177 We generated a Casz1 knock-out mouse using Casz1-trapped embryonic stem cells

178 A knock-out mouse was generated for GP2 to study the impac

179 This astrocytic Cav1.2 knock-out mouse was tested in the cuprizone model of mye

180 The olfactory epithelium of the knock-out mouse was thinner and showed lower expression

181 c-selective ankyrin-G(-/-) mice (conditional knock-out mouse), we report that ankyrin-G targets Nav1.

182 Using a knock-out mouse, we found that c-rel, one of the transcr

183 ld(s)) mouse and the chemokine receptor CCR2 knock-out mouse, we report that macrophage accumulation

184 Using a new alphaII spectrin conditional knock-out mouse, we show that alphaII spectrin is requir

185 lasts derived from the NF-kappaB1 (p105/p50) knock-out mouse were used to demonstrate that p50 expres

186 rther examined the role of COX2 using a COX2-knock-out mouse where pFUS was unable to increase MSC tr

187 only, with a nitric oxide synthase 2 (NOS2) knock-out mouse, which develops no AD-like pathology.

188 man mutation, we generated a new conditional knock-out mouse with a brain-specific deletion of Adk (A