1 ion of Arm with GM130 Golgi marker in Klp64D
knockdown.
2 with the microtubule network upon a3-subunit
knockdown.
3 ype that was prevented by selective GSK3beta
knockdown.
4 d by urea, and unaffected by HSP70 and HSC70
knockdown.
5 d by pharmacological inhibition and PKCdelta
knockdown.
6 ase kinase (MEK) (trametinib) and with STAT3
knockdown.
7 ed sensing of FA fluxes perturbed via ALKBH5
knockdown.
8 of bamA, tolB, and lptD and found that these
knockdowns activated T6SS activity.
9 either BFA treatment nor siRNA-mediated ARF1
knockdown affecting HAZV gene expression.
10 HDAC inhibitors synergize with BPTF
knockdown against HGG growth.
11 FACT
knockdown also increases epigenetic marking by dCas9-bas
12 Myeloid-specific Wnt5A
knockdown also led to decreased lung metastasis.
13 KLF7
knockdown also results in the down-regulation of Discs L
14 type specific GSK3B knockdown, but not GSK3A
knockdown,
also reversed abnormal gamma oscillations and
15 Mechanistically, MAARS
knockdown alters HuR cytosolic shuttling, regulating HuR
16 ole of RPS6KB1 in regulating MuV using siRNA
knockdown,
an inhibitor, and RPS6KB1 knockout cells.
17 In human tumor cell lines, ABCC4
knockdown and inhibition reduced full-length GLI3 levels
18 Using a combination of
knockdown and inhibitor-based approaches, our work chara
19 ssessing the role of PLK1 have relied on RNA
knockdown and kinase inhibition approaches, as Plk1 null
20 In this study, we use both
knockdown and knockout of IQGAP1 to investigate its role
21 Moreover,
knockdown and knockout of prokr1b altered the correct de
22 Both Rab10
knockdown and LRRK2 kinase inhibition potently suppress
23 We find that PTBP1
knockdown and MSI1 and PCBP2 overexpression are sufficie
24 In a NF2-mutant sRCC model, YAP1
knockdown and NF2 reconstitution suppressed cell prolife
25 SNORD26 and SNORD96A
knockdown and overexpression were undertaken using antis
26 Lentiviral shRNA
knockdown and reconstitution experiments revealed that b
27 hat POU3F2 regulates 42 SCZ-related genes in
knockdown and RNA-sequencing experiments of human neural
28 A therapeutic meaningful effect of MT2A
knockdown and subsequent cisplatin treatment could be ob
29 Analysis of genes regulated by PJA1
knockdown and TGFbeta1 signaling revealed 1,584 co-upreg
30 Intriguingly, Tim-3
knockdown and Tim-3 blockade increased HIV-1 replication
31 Here, using gene
knockdowns and clonogenic survival and cell viability as
32 Isoform-specific small interfering RNA
knockdowns and isoform-selective PI3K inhibitors identif
33 retrograde tracing, gene overexpression and
knockdown,
and axonal quantification to compare the func
34 Finally, quantitative imaging, conditional
knockdown,
and optical highlighting indicate that papili
35 ic labeling assays, FADS3 overexpression and
knockdown approaches, and plasma LCB profiling in FADS3-
36 regulatory proteins, using overexpression or
knockdown approaches, did not establish causal roles for
37 Knockdown assays found that seven candidate genes signif
38 Cell-type specific GSK3B
knockdown,
but not GSK3A knockdown, also reversed abnorm
39 MEK5
knockdown by RNA interference sensitizes prostate cancer
40 Here, Abi1
knockdown by shRNA reduced human airway smooth muscle ce
41 Specifically attenuating CRL4(CDT2) by CDT2
knockdown can be more potent in killing cSCC cells than
42 Both RBX2 knockout and Cullin 5
knockdown cause hippocampal pyramidal neuron mislocaliza
43 ds of the more aggressive phenotype, ERalpha
knockdown caused a phenotypic change to that of the less
44 SAR1B
knockdown caused loss of lipoprotein secretion, overexpr
45 Lastly, MYT
knockdown caused stress-gene overactivation and death in
46 SERBP1
knockdown causes delay in tumor growth and impacts cance
47 However, Rab27a
knockdown cells had an unexpected advantage at initial s
48 ZEB1-
knockdown cells had increased sensitivity to gemcitabine
49 Treating PTPRF
knockdown cells with GSK3 inhibitor rescued the expressi
50 MUC1-expressing cells as compared with MUC1
knockdown cells.
51 s, however, were altered in Sin3A+Sam-S dual
knockdown cells.
52 Wild-type and MUC2-
knockdown colonoids infected with EAEC strains exposed a
53 d CCPs to quantify CME progression in 11 EAP
knockdown conditions.
54 Kinome-
knockdown confirmed dependency on ERBB-signalling and G2
55 Ube2v1
knockdown decreased aggregate accumulation caused by Cry
56 In several cell lines, GLS2
knockdown decreased cell proliferation and glutamine-lin
57 nd immunoblotting analyses showed that MEOX1
knockdown decreased expression of tyrosine kinase 2 (TYK
58 Moreover, shRNA-induced Gadd45b
knockdown decreases expression of genes involved in psyc
59 Intriguingly, although ATF6alpha
knockdown did not alter Xbp1 splicing dynamics or intens
60 ss measurable TRPM7 currents; however, siRNA
knockdown did not directly affect action potential morph
61 l migration as effectively as ST3GALIII-gene
knockdown did.
62 Furthermore, shRNA COASY
knockdown disrupted downstream PI3K pathway activation a
63 Conversely, furin
knockdown downregulated IGF1R-beta and p-STAT3 (Tyr705)
64 We were able to achieve over 90%
knockdown efficacy and maintain it for 2 weeks effective
65 Knockdown efficacy is driven by gRNA-specific features a
66 er two or three dOs by one VMO yielded > 85%
knockdown efficiency.
67 ed by Infection (IBIN) was diminished in osa
knockdown flies.
68 piggyback knockdown method that was used to
knockdown genes in adult zebrafish.
69 eria Micrococcus luteus In this setting, osa
knockdown had a particularly strong effect on immune eff
70 Cells with LKB1
knockdown had a reduced rate of oxygen consumption, whic
71 of USP7 and USP10 by chemical inhibitors or
knockdown had an additive effect on NHE3.
72 nd cisplatin, whereas AsPC-1 cells with ZIP4
knockdown had increased sensitivity to these drugs.
73 RNA sequence analysis of pn-csERRalpha/gamma
knockdown hearts at 5 weeks of age combined with chromat
74 in 3D gels reversed the effect of HIF-2alpha
knockdown;
HIF-2alpha siRNA increasing osteoclast format
75 esistance and HR repair efficiency after TTK
knockdown;
however, reintroduction of kinase-dead TTK di
76 gene networks affected by TEADi and YAP1/TAZ
knockdown identifies KLF4 as a central transcriptional n
77 s was disproportionately affected by RPLP1/2
knockdown,
implying a role for RPLP1/2 in multi-pass tra
78 oreover, we demonstrated that IPO4 and CEBPD
knockdown improved CDDP-induced cytotoxicity in vitro an
79 Ube2v1
knockdown improved ubiquitin proteasome system performan
80 TET2
knockdown in BRCA2-deficient cells protected stalled rep
81 A-KO mice and short hairpin RNA-mediated DRA
knockdown in Caco-2 cells.
82 ts induced miR-375 expression, whereas ATOH1
knockdown in classical MCC cell lines reduced miR-375 ex
83 AAV-mediated, conditional Rit2
knockdown in DAergic neurons impacted baseline DAT surfa
84 his effect was partly attenuated through ILK
knockdown in exosomes.
85 AHR
knockdown in glioblastoma cells also reduced the express
86 We used a mouse model with Tbx5 conditional
knockdown in Hh-receiving cells (marked by Gli1+) during
87 SHIP-1
knockdown in HUVEC cells resulted in enhanced EndoMT ind
88 NFLP was also shown to phenocopy the PYCR1
knockdown in MCF10A H-RAS(V12) breast cancer cells by in
89 Consequently, tau
knockdown in mouse islet beta-cells facilitates microtub
90 Intriguingly, in vivo circHomer1a
knockdown in mouse OFC resulted in specific deficits in
91 MUC1
knockdown in pancreatic cancer cells enhanced unfolded p
92 umbens enhanced alcohol consumption, whereas
knockdown in the basolateral amygdala (BLA) decreased al
93 Furthermore, D1R-MSN-specific CRY-
knockdown in the NAc reduced susceptibility to stress-in
94 Importantly, profilin 2
knockdown in the ventral tegmental area did not affect a
95 -mediated, conditional and inducible DAergic
knockdown in vivo.
96 -CRISPR/Cas9-targeted mutation or morpholino
knockdown in zebrafish, results in Sox2 downregulation a
97 irpin RNAs (shRNAs) can induce gene-specific
knockdowns in two cnidarian species.
98 ated in X. tropicalis larvae with morpholino
knockdowns,
in which expression of truncated ZMYM2 prote
99 Conversely, hepatic LGR4
knockdown increased hepatic cholesterol synthesis and de
100 We further demonstrated that SOX9
knockdown increases cellular sensitivity to cisplatin, w
101 epatocyte and HCC cells found that cyclin D1
knockdown induced the expression of a large network of H
102 o other known spindle-regulating genes, Shot
knockdown induces apoptosis in the absence of Jun kinase
103 Furthermore, both VEGF and NRP-1
knockdown inhibit the growth of patient-derived GBM xeno
104 on) in the dorsal hippocampus and that SETD6
knockdown interferes with memory consolidation, alters g
105 the single cell biosensor and transient gene
knockdown into the system revealed the formation of inva
106 Our study shows that Gys1
knockdown is a powerful means to prevent LD progression,
107 The elevated memory produced by Ras
knockdown is a result of increased ARM.
108 Importantly, the Plk1
knockdown is specific and does not affect other Plk memb
109 ge to the proteome and ubiquitinome in USP11-
knockdown (
KD) cells in the presence of estradiol.
110 g-chain FAs (LCFAs) into skeletal muscle and
knockdown (
Kd) of a subset of RabGAP substrates, Rab8, R
111 we show that mice with inducible conditional
knockdown (
KD) of Dsc2 in IEC (Villin-Cre(ERT2); Dsc2 (f
112 Using
knockdown,
knockout, and ectopic expression systems, we
113 In macrophages, GPR101
knockdown limited the ability of RvD5n-3 DPA to upregula
114 Transgenic
knockdown lines of DGK2 and DGK4 confirmed the gametophy
115 We recently developed a piggyback
knockdown method that was used to knockdown genes in adu
116 igh levels of knockdown, pn-csERRalpha/gamma
knockdown mice exhibited cardiomyopathy with an arrest i
117 lotho heterozygous pups originated from gcKL
knockdown mice than would be expected by mendelian inher
118 activation in hearts of pn-csERRalpha/gamma
knockdown mice.
119 In response to VDR-
knockdown mitochondrial function and related gene-set ex
120 FN), which could be limited by CGAS or STING
knockdown,
mitochondrial DNA depletion or mitochondrial
121 mice, a tamoxifen (TAM)-inducible IL-4Ralpha
knockdown model to investigate the role of IL-4/IL-13 si
122 bule-branched network interface, whereas APC
knockdown nearly eliminates branched actin in growth con
123 Fam20C
knockdown not only confirmed the role of Fam20C itself i
124 Additionally, NTAL-
knockdown (
NTAL-KD) in APL cell lines led to activation
125 ecapitulate lung developmental defects after
knockdown of a critical regulatory gene, and permit mode
126 Knockdown of ABCC4 expression markedly blunted the const
127 Of note, results from siRNA-mediated
knockdown of activating transcription factor 4 (ATF4) an
128 In TNBC cells,
knockdown of ADAR1 attenuates proliferation and tumorige
129 2, and daf-16) and animals subjected to RNAi
knockdown of age-related genes (age-1 and daf-16).
130 In Drosophila, RNAi mediated
knockdown of Alk led to decreased triglyceride levels.
131 Our finding shows that the dsi-RNA
knockdown of all three candidate genes suppressed glycog
132 pharmacological inhibition or viral-mediated
knockdown of alpha2delta-1, prevents cocaine-induced gen
133 We also performed
knockdown of argonautes and rnaseh separately along with
134 Moreover, conditional
knockdown of ARID1 in the generative cell causes reduced
135 Knockdown of Ash1l, Ezh2, Kdm5b, and Kdm6b by specific s
136 Knockdown of ASPP2 upregulated DeltaNp63alpha and revers
137 Knockdown of ATG5 in HCT-116 cells increased numbers of
138 Knockdown of AtPAM16L caused reduction in mitochondrial
139 ince protein kinase A inhibition by H-89 and
knockdown of beta-arrestin 1 or beta-arrestin 2 did not
140 influenced invasion in culture, simultaneous
knockdown of both isoforms strongly reduced the invasive
141 n specifically in the atria, atrial-specific
knockdown of calcitonin promotes atrial fibrosis and inc
142 C cell growth that was rescued by concurrent
knockdown of CD44v Silencing p53 phenocopied the loss of
143 Additionally, neuronal RNAi-mediated
knockdown of Cdk8 in flies results in semi-lethality.
144 calizing to the pericentriolar material, and
knockdown of Cep85l causes a neuronal migration defect i
145 ted genes linked to known neuronal pathways,
knockdown of circZNF827 deregulates expression of numero
146 Knockout or
knockdown of CK5 ablated beta-catenin transcriptional ac
147 Stable
knockdown of CLEC16A in EBV-positive Raji B cells result
148 Knockdown of CPEB4 in LX2 HSCs prevented PFKFB3 overexpr
149 Inhibition or
knockdown of CPEB4 or PFKFB3 prevents HSC activation and
150 Knockdown of CPSF6 significantly decreased the expressio
151 Knockdown of CTCF in K562 cells caused loss of CTCF bind
152 We found that
knockdown of CYP2J2 elicits widespread alterations in ge
153 Loss or
knockdown of delta-catenin uncoupled this coordination,
154 ties of astrocyte DISC1, we assessed whether
knockdown of Disc1 (Disc1-KD) in mature mouse astrocytes
155 While
knockdown of either LIMK1 or LIMK2 only minimally influe
156 While TET3 overexpression augments HGP,
knockdown of either TET3 or the P2 isoform alone in the
157 Small interfering RNA (siRNA)
knockdown of endogenous BK channels had similar effects.
158 y a mast cell stabilizer, COX2 inhibitor, or
knockdown of EP2.
159 Finally,
knockdown of EPHB2 prevented ethanol inhibition of L1 ad
160 tion or upon genetic manipulation, including
knockdown of escargot, or overactivation of mTor or Toll
161 LC cell lines H1975, HCC827, and YLR086, and
knockdown of FGFR1 attenuated hypoxia-induced EGFR TKI r
162 rrent, but not individual, short hairpin RNA
knockdown of FLOT1/2 and AP2A1/2 reduced IGF1R associati
163 Conversely,
knockdown of for in pr1 cells phenocopies the for null m
164 Knockdown of FZD7 improved sensitivity to platinum, decr
165 In vitro
knockdown of GalR1 in cholangiocytes reduced alpha-smoot
166 The
knockdown of GATA6-AS1 did not affect undifferentiated c
167 Knockdown of GDH1 significantly reduced the cell prolife
168 Knockdown of GDPGP1 in mouse neurons leads to widespread
169 Knockdown of GM-CSF in tumor cells also delays tumor pro
170 blocked the effects of LPI, and the in vivo
knockdown of GPR55 was sufficient to improve liver damag
171 In vitro,
knockdown of GPRC5B in human aortic SMCs resulted in inc
172 Mechanistically, we show that
knockdown of GPRC5B increased the membrane localization
173 Knockdown of GULP1 in UCB cells promoted tumor cell prol
174 Furthermore,
knockdown of HB-EGF in rat islets blocks beta-cell proli
175 inical utility and safety of pharmacological
knockdown of HDAC8 in diseased cells.
176 Knockdown of HIF-1alpha did not affect osteoclast differ
177 Knockdown of IFIT1 restored parainfluenza virus 5 infect
178 cell lines (YT and SNK-6 cells) showed that
knockdown of IL18RAP inhibited cell proliferation by cel
179 Small interfering RNA
knockdown of KAT2A or H3K9ac inhibition prevented the TG
180 Knockdown of LASP1 in cultured rat hippocampal neurons r
181 Knockdown of LINC00346 inhibited expression of activated
182 shRNA-mediated
knockdown of Lmo4 in the nucleus accumbens enhanced alco
183 Knockdown of LRP1 significantly reduced tau uptake in H4
184 Stable
knockdown of LYCAT in NSCLC cell lines not only reduced
185 ibitors of MET or c-Src or by siRNA-mediated
knockdown of MET.
186 results in 87-92% phenotypic males, whereas
knockdown of miR-1-3p by an inhibitor results in 67-77%
187 Knockdown of MT2A expression levels resulted in signific
188 beta, syncytin 1, syncytin 2, and GCM1; and
knockdown of NPFFR2 abolished these effects.
189 Knockdown of NRF2 inhibited spheroid formation by drivin
190 Moreover, soma-specific
knockdown of nsun-1 reduced body size and impaired fecun
191 Furthermore,
knockdown of NTN4 in breast cells increased cell prolife
192 Chemical inhibition and morpholino
knockdown of nuclear estrogen receptor 2b (esr2b) increa
193 Similarly, following siRNA-mediated
knockdown of ODC1, UC cells undergo double-strand DNA br
194 In vivo, the
knockdown of osa and brahma was shown to enhance the exp
195 Through an unbiased RNAi screen,
knockdown of OTUD5 is shown to significantly accelerate
196 RNAi-mediated
knockdown of PERK or eIF2alpha abrogated the endorepelli
197 Knockdown of PI4KIIalpha-but not the related PI4KIIbeta-
198 SOCs were reduced by PKCdelta inhibitors and
knockdown of PKCdelta expression.
199 Knockdown of PTPN2 in either macrophages and/or IECs inc
200 ses proliferation and tumorigenesis and that
knockdown of Rab13 blocks these effects.
201 We show that
knockdown of Rab18 reduces the size of focal adhesions (
202 Knockdown of Rab5A, Rab5C, or USP15 interferes with EL t
203 Conversely,
knockdown of RAD51AP1 (RADP51AP1 KD) in breast cancer ce
204 Similar to Ras,
knockdown of Raf enhanced ARM consolidation and impaired
205 Knockdown of RGS12 in OSCC cells significantly increased
206 rties of cellular transformation, while RNAi
knockdown of SEMA4C promotes adhesion and reduces cellul
207 he effects of short interfering RNA-mediated
knockdown of Setd6 in the rat dorsal hippocampus during
208 Knockdown of sigma3 does not impact reovirus RNA synthes
209 Knockdown of Smad7 alleviated deficient ECM production i
210 oth in vitro and in vivo Here, we found that
knockdown of SNAP23 inhibited the association of the aut
211 Conversely,
knockdown of SPARC up-regulated RGS4 in Min6 cells.
212 Knockdown of Spata18 suppresses mitophagy, disturbs mito
213 KRAS increases SREBP1 expression and genetic
knockdown of SREBP1 significantly inhibited the cell pro
214 Knockdown of the 3-HIB-forming enzyme 3-hydroxyisobutyry
215 and structured illumination microscopy that
knockdown of the a3-subunit altered the diameter and den
216 Knockdown of the dominant ALDH isoform in high AVS HNSCC
217 eting ubiquitin E3 ligases and observed that
knockdown of the E3 ligase Kelch-like protein 42 (KLHL42
218 Knockdown of the gene ttpa encoding for the VitE regulat
219 Pharmacological blockade and
knockdown of the melanocortin-4 receptor gene in the DMV
220 clustering from cytochrome c release, while
knockdown of the Rab5 exchange factor Rabex-5 impairs bo
221 transporter inhibition assays and transient
knockdown of the SLC47A1 gene, in conjunction with quant
222 Knockdown of these factors in cuSCC cell lines suppresse
223 containing hnRNP-K/L proteins and show that
knockdown of these factors strongly augments NGFR regula
224 siRNA-induced
knockdown of these receptors antagonized TOPflash report
225 Knockdown of TiPARP reduced viral replication and increa
226 At the molecular level,
knockdown of TMPRSS13 in breast cancer cells led to incr
227 Similarly, RNAi-mediated
knockdown of Tom70 in the developing eye causes rougheni
228 the recruitment of NEIL3 but not FANCD2, and
knockdown of TRAIP promotes FA/BRCA pathway activation.
229 We observed that siRNA-mediated
knockdown of TRIM28 and TRIM27 inhibited platelet-derive
230 Knockdown of USP7 or USP10 resulted in increased NHE3 ub
231 Fs with acrylamide and small interfering RNA
knockdown of vimentin significantly decreased PGCC migra
232 factors ID1 and ID3 in ILC ULA culture, the
knockdown of which diminished the anchorage-independent
233 In cultured lymphoblastic cells,
knockdown of XIST specifically altered allelic imbalance
234 shRNA
knockdown of XPB confirmed XPB degradation as the mechan
235 We demonstrated that
knockdown of XPR1, a phosphate transporter present in MI
236 ssion of maize PTPN (ZmPTPN) promoted, while
knockdown of ZmPTPN inhibited plant drought tolerance, i
237 ced macrophage migration, and siRNA-mediated
knockdowns of GR and DPP4 blocked dexamethasone-induced
238 proline cycle and proline biosynthesis, and
knockdowns of PYCR1 lead to decreased cell proliferation
239 sgenic Populus trichocarpa based on targeted
knockdowns of specific monolignol genes.
240 r of BK channels, which causes a "functional
knockdown"
of these currents and may contribute to the t
241 mTOR activator, rescued the effect of Slc7a5
knockdown on mTOR pathway activity and dendrite arbors.
242 reduced the accumulation of securin in Cdc23
knockdown oocytes.
243 onditional mutation to produce cell-specific
knockdown or deletion of a key NMDAR subunit, GluN2B, im
244 Knockdown or deletion of both ESYT1 and ESYT2 reduced st
245 sociated ubiquitin is reduced following E6AP
knockdown or displacement from proteasomes, suggesting t
246 This cell death was attenuated by
knockdown or inhibition of adenine nucleotide translocas
247 Knockdown or inhibition of DYRK1A increased HIV-1 replic
248 Knockdown or knockout of the key antiphagocytic molecule
249 1 overexpression, but reduced following Gfi1
knockdown or knockout, which was associated with a decli
250 Knockdown or overexpression of SNORD26 or SNORD96A resul
251 siRNA
knockdown or pharmacologic inhibition [GKT137831 (Setana
252 Endogenous Yap activation by lats1/2
knockdown or Rho-GTPase stimulation mimicked Yap overexp
253 The
knockdown or upregulation of different cellular componen
254 so performed RNA-sequencing analysis in JAB1-
knockdown OS cells and identified 4110 genes that are si
255 RUSC2
knockdown phenocopied the EHD1 depletion effects.
256 , each has a unique localization pattern and
knockdown phenotype, demonstrating centralspindlin-indep
257 With high levels of
knockdown,
pn-csERRalpha/gamma knockdown mice exhibited
258 d filopodia formation in shRNA-induced DAAM2-
knockdown podocytes.
259 (by autocamtide-2-related peptide) or IP(3)R-
knockdown prevented the CaMKII-hyperphosphorylation and
260 PHIP
knockdown produced substantial suppression of tumor grow
261 Epigen
knockdown profoundly reduces metastatic outgrowth and sw
262 Further, we find that A3B
knockdown re-sensitises resistant cells to cisplatin, an
263 KLHL42
knockdown reduced fibrotic tissue production and decreas
264 EGFRvIII-specific
knockdown reduced MMR protein expression thereby increas
265 tified several drosophila CYPs (dCYPs) whose
knockdown reduced PCB 28-derived OH-metabolites and supp
266 siRNA-mediated STAT3 or GLI1
knockdown reduced promoter binding of GLI1 and STAT3, re
267 lncRNA-MAP3K4
knockdown reduced the expression of key inflammatory fac
268 Abi1
knockdown reduced the recruitment of Pfn-1 to the leadin
269 BRD4S
knockdown reduces BRD4S condensation, and ectopic expres
270 GADD45alpha
knockdown rescued reduction in DeltaNp63alpha by FIH-1 d
271 KRAS
knockdown resulted in unique methylation changes with li
272 We find that MG53
knockdown results in activation of NFkappaB signalling,
273 Furthermore, miR-21/221
knockdown significantly attenuated RV but not LV fibrobl
274 Ce-lamin (lmn-1)
knockdown softened the nucleus, whereas nematode aging s
275 The PrimPol-
knockdown strain was hypersensitive to tenofovir treatme
276 Knockdown studies in cultured human MCs of RHOJ, the upm
277 Besides, a previous
knockdown study indicated that PRDM14 might be dispensab
278 Comparing knockout and inducible
knockdown systems, we find that acute depletion of DPPA2
279 tochondrial phenotype, we utilized Taz-shRNA
knockdown (
Taz(KD) ) mice, which exhibit defective cardi
280 trap to simultaneously report and reversibly
knockdown the tagged genes.
281 Tumors derived from LIMK1/2
knockdown TICs were substantially smaller and showed del
282 onents led to an enhanced overgrowth of Tsc1
knockdown tissue.
283 Single mismatches generally reduce
knockdown to a modest degree, but spacer nucleotides 15-
284 eriments with leaves from wild-type and SOT1
knockdown trees suggest that sulfated salicinoids do not
285 nnel-1 (VDAC1) in mitochondria and that INSR
knockdown triggers robust mitochondrial fragmentation, a
286 Immunoblots showed that the
knockdown tumors had potentially compensating increases
287 ha in target induction was assessed by acute
knockdown using islet cells from Atf6alpha (flox/flox) m
288 COP1
knockdown using siRNA prevents degradation of c-Jun, ETV
289 r extent, likely due to suboptimal PTEN mRNA
knockdown using this approach.
290 ess in Tsc1 loss-of-function cells upon foxo
knockdown was also confirmed by elevated expression leve
291 hotopic tumors in athymic nude mice and PAF1
knockdown was induced by administration of doxycycline i
292 A growth arrest caused by the TbCAE
knockdown was rescued by the expression of the cytosolic
293 Using siRNA- or shRNA-mediated
knockdown,
we demonstrate that, in contrast to the const
294 Using specific inhibitors and gene
knockdowns,
we show that activation of DNA-PKcs and ATM
295 l vein endothelial cells (HUVEC) with SHIP-1
knockdown were analyzed in TGF-beta1 or BLM, respectivel
296 Moreover, cells with 4E-BP
knockdown were resistant to BBR-induced cell death and w
297 m a selection of genes most affected by TET1
knockdown with a median cross-validated survival concord
298 The
knockdown with piggybacking either two or three dOs by o
299 ytes; these changes were prevented by IP(3)R
knockdown with short-interfering RNA directed against IP
300 ersprouting phenotype in Delta-like 4 (Dll4)
knockdown zebrafish embryos.