ライフサイエンスコーパス: knockout

1 ressed by targeted cell ablation and/or gene knockout.

2 ts were phenocopied with a KDM3B CRISPR/Cas9 knockout.

3 amined in 16HBE14o- single colonies with DSP knockout.

4 lus trains are unaffected by Synaptotagmin-1 knockout.

5 ese deficits were prevented by global IL-1R1 knockout.

6 either increased bicoid (bcd) dosage or bcd knockout.

7 of Hippo/YAP and c-MYC signaling upon FRMD6 knockout.

8 ed changes in an overlapping fashion between knockouts.

9 tion overuse headache in Dlx-DOR conditional knockouts.

10 mpetent 24-hour molecular pacemaker in Bmal1 knockouts.

11 and these effects are nonadditive in double knockouts.

12 Interestingly, the Gli1 knockout abrogated SULF2-mediated induction of several S

13 on independently of antiviral RNAi, and VINR-knockout adult flies exhibit enhanced disease susceptibi

14 Liver-specific AMPK knockout aggravated liver damage in mouse NASH models.

15 male mice, pigs, goats, and cattle harboring knockout alleles of the NANOS2 gene generated by CRISPR-

16 ion to the conditional alleles, constitutive knockout alleles were also obtained as byproducts of the

17 sequencing on FUS mutants in parallel to FUS knockout, allowing us to compare mutation-induced change

18 GluA1 subunit knockout also reduced mortality, severity, and duration

19 Both RBX2 knockout and Cullin 5 knockdown cause hippocampal pyrami

20 Knockout and overexpression of NPC6 decreased and increa

21 Live-cell imaging coupled with targeted gene knockouts and a high-throughput RNAi assay enabled the f

22 Using knockdown, knockout, and ectopic expression systems, we demonstrate

23 further validated it through overexpression, knockout, and inhibition of NCAM1 in Vero cells and huma

24 ice were bred to generate Lrat-CrePdgfra-/- (knockout) animals, which were subjected to chronic liver

25 lar fenestration defects were created in Ank knockout (Ank KO), Enpp1 mutant (Enpp1(asj/asj)), and do

26 We previously showed that aged adiponectin knockout (APN(-/-)) mice developed Alzheimer's like path

27 criptional and metabolic adaptations to 4CL1-knockout appear to have enabled 4CL5 catalysis at a leve

28 aP-95 cells in which CRISPR-Cas9 was used to knockout AR-FL or AR-V7 alone or in combination were eva

29 rized GEC from wild type (WT) and col4alpha5 knockout AS mice, a hereditary disorder characterized by

30 s, 4 mouse lines: wild-type, KO (CaMKIIdelta-knockout), CaMKIIdeltaC transgenic in wild-type (TG), or

31 d with accumulation of lipid vacuoles within knockout cardiomyocytes; (3) Hypoxia-inducible factor 1a

32 ptome sequencing (RNA-seq) analysis of IRAK4 knockout cell lines (IRAK4 KOs) showed that the IRAK pat

33 Knockout cells had a normal complement of TRPM1 at their

34 F711 reduced cell growth and that the double knockout cells have major defects in proliferation.

35 Add-back of MAML1 variants in knockout cells identifies residues 151 to 350 of MAML1 a

36 Selectively in ATM-knockout cells, we show that combined olaparib/AZD6738 t

37 g siRNA knockdown, an inhibitor, and RPS6KB1 knockout cells.

38 3-bromotyrosine was detected in peroxidasin-knockout cells.

39 to rescue centrosome polarization in KIF21B-knockout cells.

40 In Hs3st1(-/-) (HS 3-O-sulfotransferase-1 knockout) cells, reduced 3-O-S levels of HS diminished b

41 Here, we develop human CISH-knockout (CISH(-/-)) NK cells using an induced pluripote

42 ar disease, we generated a Kif11 conditional knockout (CKO) mouse and investigated the consequences o

43 resumption, we developed a Plk1 conditional knockout (cKO) mouse to specifically mutate Plk1 in oocy

44 vior that is observed in vitro under genetic knockout conditions.

45 By expressing mutant forms of IQGAP1 in a knockout context, we also determine that IQGAP1's pro-me

46 However, tau knockout could modestly promote the formation of alpha-s

47 Conversely, GATA3 knockout delays differentiation and prevents fast commit

48 riven by K-Ras G12D and p53 deficiency, G6PD knockout did not block formation or proliferation of pri

49 Utilizing Dock3 global knockout (Dock3 KO) mice, we found that the haploinsuffi

50 ower glycolytic enzyme expression, rendering knockout-engineered heart tissue sensitive to metabolic

51 cNAc signaling by O-GlcNAc transferase (OGT) knockout enhances macrophage proinflammatory polarizatio

52 itises resistant cells to cisplatin, and A3B knockout enhances sensitivity to chemotherapy drugs.

53 ed post-MI neovascularization, whereas IL-10 knockout EPC-derived exosome treatment showed diminished

54 ssion of Sig-1Rs rescues, whereas the Sig-1R knockout exacerbates, the (G4C2)-RNA repeats-induced abe

55 ontrast, hepatocyte-specific YAP and YAP/TAZ knockouts exhibit limited myofibroblast expansion, less

56 by which reduced Na(v) availability in Fhf2 knockout (Fhf2(KO)) mice predisposes to abnormal excitab

57 Knockouts for CTI exhibit higher rates of FAS and marked

58 pe (WT), alpha1,3-galactosyltransferase gene-knockout (GTKO), and TKO pigs by flow cytometry.

59 cer and activator of transcription 2 (STAT2) knockout hamster model to expand the repertoire of anima

60 Furthermore, we demonstrate that RAG2 knockout hamsters develop severe/fatal disease when expo

61 ced levels of cell-surface Gb3, and both AHR knockout HeLa cells and tissues from Ahr knockout mice d

62 AHR knockout HeLa cells exhibited significantly reduced leve

63 Here we report that MAFB knockout hPSCs have normal pancreatic differentiation ca

64 e DNA methylation landscape using a panel of knockout human embryonic stem cell (ESC) lines.

65 sessed in human engineered heart tissue from knockout human induced pluripotent stem cell-derived car

66 and cerebral organoids generated from PITRM1-knockout human induced pluripotent stem cells (iPSCs).

67 el CRISPR-Cas9 screens in wild-type and TP53 knockout human retinal pigment epithelial cells using a

68 However, Scnn1a knockout in a degeneration-causing mutant background acc

69 Mice with Kbtbd2 knockout in adipocytes, liver, and muscle all showed nor

70 CRISPR/Cas9-based gene knockout in animal cells, particularly in teleosts, has

71 e phosphatase activity in lesions in the Ahr knockout in comparison with wild-type mice.

72 Strikingly, GPX8 knockout in mesenchymal-like cells (MDA-MB-231) resulted

73 IRE1alpha knockout in TNBC cells markedly reversed substantial ult

74 s revealed the suppressive effect of PIERCE1 knockout in urethane- and KRAS(G12D)-induced lung tumori

75 Moreover, calpain-1 knockout in YAC84Q mice alleviated excessive fragmentati

76 Unlike in rodents, where the grin1 knockout is embryonic lethal, grin1 double-mutant fish (

77 tially expressed genes (DEGs) in Pkd2 single-knockout kidneys, which were used to identify candidate

78 s for human mRNAs and mouse mRNAs from LARP4 knockout (KO) and control cells.

79 ameters of skeletal muscle from global Zip14 knockout (KO) and wild-type mice (WT).

80 In mice, Ecm29 knockout (KO) in neurons increases the density of NKCC1

81 tered innate immune gene expression in Lrrk2 knockout (KO) macrophages is driven by a combination of

82 We generated Rab39b knockout (KO) mice and found that they exhibited cortica

83 For that, AnxA1, Fpr2/3 knockout (KO) mice and wild-type (WT) controls were infe

84 Ghrelin knockout (KO) mice and wild-type (WT) littermates underw

85 Lung tumor suppressor gene Gprc5a-knockout (ko) mice are susceptible to lung inflammation,

86 Cerebellum of Jdp2-knockout (KO) mice contains lower number of Atoh-1 posit

87 In contrast, STAT6 knockout (KO) mice exhibited worse outcomes than WT mice

88 Platelet count was normal in Chk knockout (KO) mice, reduced by 92% in Chk;Csk double KO

89 rvations, we suppressed beta-catenin in Mdr2 knockout (KO) mice, which develop sclerosing cholangitis

90 conducted with MAOIs in wild-type and TAAR1-knockout (KO) mice.

91 n FAO using a pan-brain-specific conditional knockout (KO) mouse incapable of FAO due to the loss of

92 ensation by Kv3.2 or Kv3.4 in the respective knockout (KO) mouse.

93 CRISPR-based knockout (KO) of ATP2C1 decreases transduction by differ

94 Kidney-specific knockout (KO) of Gpr116 caused a significant reduction i

95 Mice with a Purkinje-cell-specific knockout (KO) of the calcium-activated K+ channel SK2 (L

96 Mice with liver-specific knockout (KO) of the insulin receptor (IR) have a 50% re

97 ubjected mice with EC-AGO1 deletion (EC-AGO1-knockout [KO]) and their wild-type littermates to a fast

98 HFD feeding of CysC-deficient (CysC knockout [KO]) mice worsened obesity-associated adipose

99 Conversely, Nek2 knockout led to incomplete dissociation of DAs and cilia

100 ranslational repressor binding site in a CAO knockout line it was possible to continuously alter chlo

101 Simpson-Golabi-Behmel syndrome preadipocyte knockout lines each with a single IR-gene knocked out by

102 ClVST1(97) knockout lines show decreased sugar content and total bi

103 Simpson-Golabi-Behmel syndrome preadipocyte knockout lines.

104 ound reductions in WNT1 expressions in RAD6B knockout M14 cells compared with control.

105 esolution of the type I IFN response, Trim14 knockout macrophages have more phospho-Ser754 STAT3 rela

106 Remarkably, Trim14 knockout macrophages hyperinduce expression of antimicro

107 Cdkl5 knockout male mice treated with isoform 1 via intrajugul

108 h-fat (HF)-fed SkM-specific AMPKalpha1alpha2 knockout (mdKO) mice and AMPKalpha1alpha2lox/lox litterm

109 ATAC-Seq in knockout MEFs revealed that actin-dependent reduction of

110 ests the feasibility of drug design based on knockout metabolomics of drug transporters.

111 We generated cardiomyocyte-specific CITED4 knockout mice (C4KO) and subjected them to an intensive

112 tion, we generated CD11c-specific E-cadherin knockout mice (CD11c-Ecad(del)).

113 valent PCB congener in human tissues, on SXR knockout mice (SXRKO) and to elucidate the role of SXR i

114 disease, deficient in innate lymphoid (Il2rg knockout mice [Il2rg (KO)]), adaptive immune (Rag1 knock

115 ut mice [Il2rg (KO)]), adaptive immune (Rag1 knockout mice [Rag1 (KO)]), or both systems (Il2rg (KO)/

116 ney fibrosis in normal mice but not in OASIS knockout mice after UUO, signifying Bst2 functions downs

117 ses in NEX-Cre lineage in double conditional knockout mice also generates similar tumours, which are

118 in vivo or in vitro, as assessed with alpha7-knockout mice and by performing alpha-bungarotoxin (alph

119 We used endothelium-specific knockout mice and high-fat diet-fed mice to assess the r

120 al mouse cochlea and compared SGNs in Pou3f4 knockout mice and littermate controls.

121 and energy metabolism, we show that PHOSPHO1 knockout mice are cold-tolerant, with higher expression

122 ory cell infiltration was initially lower in knockout mice but later increased, leading to an accumul

123 nued alleviation of hepatocellular injury in knockout mice despite ongoing carbon tetrachloride insul

124 Podocyte-specific beta-PIX knockout mice developed progressive proteinuria and kidn

125 Although analyses of Fgf8 conditional knockout mice did not reveal developmental phenotypes, t

126 m DC patients and late generation telomerase knockout mice display lower nicotinamide adenine dinucle

127 Consequently, conditional D2R knockout mice displayed a significant reduction in diggi

128 al kidney tubule-specific ENaC gamma-subunit knockout mice displayed decreased claudin-8 expression,

129 AHR knockout HeLa cells and tissues from Ahr knockout mice displayed decreased sphingolipid content a

130 ration of NSCs and neurogenesis seen in Ccn1 knockout mice eventually returned to normal, the expande

131 tion of CB1, CB2, or GPR55 receptors in gene-knockout mice failed to alter BCP's action against cocai

132 Knockout mice for the kisspeptin receptor, Kiss1r (Kiss1

133 TNC knockout mice had an altered eosinophil recruitment prof

134 scopic analysis showed that podocytes of the knockout mice had distinctive foot process effacement an

135 Tumors formed in WNT5A knockout mice had elevated cytotoxic T cells, increased

136 We have previously reported that Glrx knockout mice had increased protein S-glutathionylation

137 Intestinal tissues from neonatal S100-knockout mice had reduced levels of CX3CR1 protein, and

138 We generated conditional knockout mice in which brain AMPKalpha isoforms are sele

139 because of perinatal lethality exhibited by knockout mice lacking all three APP family members.

140 In C57BL/6 gene knockout mice lacking either functional TCRs or MHC clas

141 bule-specific overexpression of periostin or knockout mice lacking periostin expression in the renal

142 to induce diabetes in wild-type C57BL/6 and knockout mice lacking the genes encoding G protein-coupl

143 nterstitial lung macrophages was observed in knockout mice of WT-knockout pairs.

144 uscle or adventitia, miR-210 was observed in knockout mice of WT-knockout pairs.

145 or by 5/6 nephrectomy; we also used AhR(-/-) knockout mice overloaded with indoxyl sulfate in drinkin

146 l miRNAs showing altered expression in FKBP5 knockout mice play a potential role as epigenetic marker

147 ndocardial Kruppel-like factor 2 in Adamts19 knockout mice precedes hemodynamic perturbation, showing

148 gulator of atherosclerotic burden in miR-144 knockout mice receiving a high fat diet.

149 In loss of righting reflex assessment, knockout mice revealed increased sensitivity to alcohol-

150 Applying our approach to knockout mice revealed that Piezo2 differentially tunes

151 re, we generated inducible, EC-specific Pkd2 knockout mice to examine vascular functions of PKD2.

152 We also used knockout mice to investigate the role of TNF receptors 1

153 Exacerbated viral pathogenesis in Ly6e knockout mice was accompanied by loss of hepatic immune

154 specific 35% nephron deficit in microRNA-210 knockout mice was observed.

155 S100-knockout mice weighed 21% more than wild-type mice at ag

156 TMIGD1 knockout mice were developed, and the loss of TMIGD1 in

157 Furthermore, IRAK1 knockout mice were protected from LPS-induced PTB, which

158 f Lsh in hematopoiesis using conditional Lsh knockout mice with expression of Mx1 or Vav Cre-recombin

159 y showing that the genetic deficiency of AR (knockout mice) prevented alcohol-induced increase in har

160 formed small-RNA sequencing on liver of Tsc1-knockout mice, and found that miRNAs of the delta-like h

161 subcellular distribution in wild-type mice, knockout mice, and receptor-positive and receptor-negati

162 nes but was inactive in membranes from GPR88 knockout mice, even at a concentration of 100 muM.

163 ier function, junctional adhesion molecule A knockout mice, F11r(-/-) .

164 In Cyp26b1 conditional knockout mice, formation of striolar/central zones is co

165 In ST2 knockout mice, IL-33 and OVA induced airway hyperrespons

166 In Gal-3 knockout mice, scar thinning ratio, expansion, and cardi

167 urons (iMSNs) in the ventral striatum of D2R knockout mice, this mutant restored basal locomotor acti

168 EC cell lines and colonoids derived from CRT-knockout mice, we found that CRT regulates energy balanc

169 Using miR-210 replete (wild-type [WT]) and knockout mice, we tracked blood-borne miR-210 using bone

170 and behavioral deficits in Mecp2 conditional knockout mice, whereas about 12-fold decrease in Wnt6 mR

171 mTOR, or Rheb, rescues HSC defects in Sel1L knockout mice.

172 or-negative intercalated cells from the same knockout mice.

173 ear factor erythroid 2-related factor (Nrf2) knockout mice.

174 owing intranasal instillation of H1N1 in Rag knockout mice.

175 ogical evidence of PAH in hematopoietic Tet2-knockout mice.

176 mineralocorticoid receptor expression in the knockout mice.

177 stration of carbon tetrachloride), and CPEB4-knockout mice.

178 is observed on brain slices taken from CLC-2 knockout mice.

179 ulated in intestinal stem cell-specific Tsc1 knockout mice.

180 ession model of migraine aura in conditional knockout mice.

181 ribution to itch by analysing Na(V)-specific knockout mice.

182 re mice bred muscle-specific NO66 (MCK-NO66) knockout mice.

183 nerated Langerin-specific and CD11c-specific knockout ((-/-)) mice lacking AhR, respectively, in LC a

184 Individual gene knockouts mirrored many of the observed changes in an ov

185 g the angiomyolipoma cell line 621-101, MITF knockout (MITF.KO) and MITF-A overexpressing (MITF.OE) c

186 Here, we show with a reversible knockout model that re-expression of Brg1, in conjunctio

187 ism underpinning ataxia in this global Asic5 knockout model was elaborated using brain slice electrop

188 CHARGE patient-derived iPSCs and conditional knockout mouse brains.

189 ceptor homeostasis in vivo by using an Erdj5 knockout mouse crossed with the P23H knock-in mouse and

190 rentiation assays reveal that Dppa2/4 double knockout mouse embryonic stem cells fail to exit pluripo

191 in dominance behavior by using a conditional knockout mouse for G protein subunit Galphai2, which is

192 Sod1(G86R) and Fezf2 knockout mouse lines were crossed to generate a model th

193 A knockout mouse model allows dissociation of the coordina

194 We created a Ewsr1 conditional knockout mouse model to deplete EWSR1 before the onset o

195 In this study, using a knockout mouse model, we show that the transcription fac

196 ction on the mammalian brain, we generated a knockout mouse model.

197 cess in the hepatic conditional beta-catenin knockout mouse model.

198 ed the photoreceptors of a heterozygous Opa1 knockout mouse model.

199 With the development of knockout mouse models and molecular inhibitors unique to

200 The combination of conditional knockout mouse models and viral vector-mediated autophag

201 VHL complex coupled with conditional genetic knockout mouse models, we further discovered that the E3

202 of IRE1alpha and Xbp1 mRNA splicing in TLR2 knockout mouse retina.

203 by impaired glutathione synthesis, the Gclm knockout mouse, oxidative stress activated MMP9 (matrix

204 phenotype in a mouse model of LGMD R1 (CAPN3 knockout mouse-C3KO) was studied.

205 s of CpRbp1 were performed by constructing a knockout mutant and analyzing the resulting heterokaryon

206 Finally, knockout mutants for 41 genes belonging to the different

207 arization, while CRISPR-Cas9-mediated single knockout mutants showed precocious endosperm cellulariza

208 cluded novel results on associations between knockout-mutations and all AraPheno traits.

209 gen 2 (Bst2) expression was reduced in OASIS knockout myofibroblasts.

210 uorescent chimeras were expressed in triadin knockout myotubes, and their mobility was compared with

211 CRISPR-mediated CD47 and HER2 dual knockouts not only inhibit clonogenicity but also enhanc

212 In Ybx1-knockout NPCs, H3K27me3 reduction by PRC2 enzymatic inhi

213 in cell lines with the CRISPR/Cas9-mediated knockout of 4E-BP1.

214 grative analysis of the epigenome map, and a knockout of a predicted upstream regulator disrupts norm

215 ing greening in the presence of ABA, whereas knockout of ABT has the opposite effect.

216 -fat-diet (HFD)-fed mice with liver-specific knockout of both AMPK catalytic alpha1 and alpha2 subuni

217 ncentrations in the skin while the postnatal knockout of both Cyp26a1 and Cyp26b1 resulted in increas

218 Knockout of C/EBPbeta in AD mouse models diminishes ApoE

219 inflammation seen in animals with a complete knockout of C9orf72.

220 nabinoid signaling, we induced MSDB-specific knockout of CB1 or MAGL via injection of virally-deliver

221 However, knockout of cellular 5' tyrosyl-DNA phosphodiesterase 2

222 Postnatal knockout of Cyp26b1 resulted in increased atRA concentra

223 Knockout of DNMT3A in human cardiomyocytes had three mai

224 Knockout of DSP in 16HBE14o- cells decreased transepithe

225 was an inhibitor of IAV replication because knockout of eEF1D resulted in a significant increase in

226 Mosaic knockout of either PKS or GCM revealed spatial lineage c

227 Knockout of FAM122A results in activation of PP2A-B55alp

228 Furthermore, CRISPR-mediated knockout of FN3K in human liver cancer cells altered the

229 Knockout of Gdf6 in a mouse model resulted in cochlear a

230 We found that conditional knockout of Grp in sensory neurons results in attenuated

231 Furthermore, knockout of IFITM3 reduces gamma-secretase activity and

232 IL37 receptor (IL37R) by antibody or CRISPR knockout of IL37 in lung cancer cell lines repolarized T

233 In this study, we use both knockdown and knockout of IQGAP1 to investigate its role in the metast

234 rtilage-specific expression of nls-YAP5SA or knockout of Lats1/2 do not increase cartilage growth, bu

235 CRISPR knockout of LIN28B-an oncofetal RNA-binding protein exer

236 ISCs with knockout of LKB1 increased the expression of PDK4 and ha

237 Knockout of Mastermind-like 1 (MAML1) eliminates Notch-r

238 ale-determining factor (M factor) as somatic knockout of Nix led to feminized males (M/m) while trans

239 ues the lam1 mutant, both overexpression and knockout of NsWOX9 in N. sylvestris resulted in a range

240 Genetic knockout of one allele of Eprs globally (Eprs(+/-)) usin

241 fer endogenous peptide activity, and genetic knockout of opioid peptide precursors.

242 Knockout of pcdr-1, slo-1, or homt-1 (a gene required fo

243 Moreover, knockdown and knockout of prokr1b altered the correct development of G

244 quiescent and inactive HSCs, and conditional knockout of Sel1L in hematopoietic tissues drives HSCs t

245 ), we achieved near population-level genetic knockout of single and multiple targets in a range of ce

246 Functionally, knockout of SNORD42A reduced colony formation capability

247 Genetic knockout of Sting was sufficient to completely prevent n

248 Conditional knockout of TAK1 in microglial/infiltrated macrophages a

249 In this work, we show that knockout of the m(6)A writer Mettl3 or the nuclear reade

250 n genetic background yields viable pups, and knockout of the MCU in adult heart does not cause lethal

251 We utilized a mouse model carrying a knockout of the mitochondrial fusion-fission-related gen

252 Moreover, perturbation of OSN function via knockout of the odorant receptor (OR) co-receptor, Orco,

253 A global knockout of the receptor for monocyte chemoattractant pr

254 Knockout of USP10 or G3BP1 family proteins increased lys

255 We observe that knockout of vinculin attenuates, but does not completely

256 CRISPR-Cas9 knockout of VINR in Drosophila cells enhances DCV replic

257 molars, Wnt4 was increased after epithelial knockout of Wnt10a.

258 Knockout of Yap1 in the adult mouse RPE caused cell depo

259 larly interspaced short palindromic repeats) knockouts of individual 15q13.3 microdeletion genes.

260 In parallel, we generated multiple CRISPR knockouts of the fly rrp4 gene.

261 Cep55-knockout offspring show microcephaly and primary neural

262 Of note, the effect of the PPHD knockout on antibiotic resistance was phenocopied in bac

263 e effects of G protein subunit beta 5 (Gnb5) knockout on insulin secretion.

264 In this study, we found that Opn3-knockout (Opn3-KO) mice were prone to diet-induced obesi

265 CRT-knockout organoids also had diminished barrier formation

266 LSH knockout pachytene oocytes exhibit reduced HDAC2 and DNM

267 rophages was observed in knockout mice of WT-knockout pairs.

268 miR-210 was observed in knockout mice of WT-knockout pairs.

269 LRP growth was restored in ore1-2 knockout plants by genetically inducing cell elimination

270 14 degradation by HPV16 E7 and PTPN14 CRISPR knockout repress keratinocyte differentiation-related ge

271 Ventralization in Ankmy2 knockout requires both cilia and Gli2 activation.

272 ting E7 binding to PTPN14 and using a PTPN14 knockout rescue experiment, we demonstrate that the degr

273 Using a CRISPR-mediated knockout screen, we identify SLC35B2 and myosin-7B (MYO7

274 onse in ES cells, we performed a CRISPR-Cas9-knockout screen.

275 Pooled library CRISPR/Cas9 knockout screening across hundreds of cell lines has ide

276 nesis, here we employed a genome-wide CRISPR knockout screening approach to systemically identify the

277 Using pooled CRISPR-Cas9 knockout screens, we showed that teratomas can enable si

278 We performed a CRISPR-Cas9-knockout selection designed to identify host factors req

279 Further, Shank3 knockout severely compromised the in vivo ability of vis

280 s has ever been described, and murine Nmnat1 knockouts show embryonic lethality, indicating that comp

281 evidence that SMC-specific Klf4- versus Oct4-knockout showed virtually opposite genomic signatures, a

282 In addition, GPX8 knockout significantly delayed tumor initiation and decr

283 We also analyze variation in 2329 knockout strains and establish a reference for the magni

284 Photoreceptor-specific Stx3 knockouts [Stx3 (f/f(iCre75)) and Stx3 (f/f(CRX-Cre)) ]

285 Triadin knockout syndrome (TKOS) is a potentially lethal arrhyth

286 Using CRISPR-Cas9 knockout technology, we show that these two lipid recept

287 Triple-knockout (TKO) pigs (with added protective human transge

288 ically screened for loss- and gain-of-memory knockouts to identify memory regulators in thousands of

289 nt wild-type mouse backgrounds as well as in knockout, transgenic, and other types of genetically eng

290 Nephron-specific TrkC knockout (TrkC-KO) and nephron-specific TrkC-overexpress

291 C57Bl/6 or TSP-1 knockout (TSP-1(-/-)) mice were injected with azoxymetha

292 reduce activity of caspases 3 and 7 in TTC7A-knockout (TTC7A-KO) HAP1 (human haploid) cells and reduc

293 SerpinB2 knockout tubular cells showed significantly reduced expr

294 as integrated with gene expression from E2F2 knockout tumors in an MMTV-Neu background.

295 We generated Paneth cell-specific VDR knockout (VDR(DeltaPC)) mice to investigate the molecula

296 lated with different contraction kinetics in knockout versus wild-type; (2) Aberrant activation of th

297 RNA-Seq analysis of ASH1L knockout versus WT ATC cell lines revealed that ASH1L is

298 ion, but reduced following Gfi1 knockdown or knockout, which was associated with a decline in the exp

299 ylation complexes I and V increased in CLPP2 knockouts, without accumulation of mitochondrial-encoded

300 metabolism, we generated a whole body gpr27 knockout zebrafish line.