ライフサイエンスコーパス: knockout mice

1 rtate receptor hypofunction (Ppp1r2cre/Grin1 knockout mice).

2 e cerebellum of control and conditional SnoN knockout mice.

3 and atherosclerosis phenotypes seen in Apoe knockout mice.

4 re mice bred muscle-specific NO66 (MCK-NO66) knockout mice.

5 attenuating chlamydial pathogenicity in CD8 knockout mice.

6 s, and villin-TLR4 mice backcrossed to DUOXA-knockout mice.

7 had more F4/80(+) macrophages compared with knockout mice.

8 rimary macrophages derived from WT and Lrrk2 knockout mice.

9 ant functions, as demonstrated by studies of knockout mice.

10 phosphorylation in strips isolated from JNK2 knockout mice.

11 scin accumulation in brains of young TAX1BP1 knockout mice.

12 at was eliminated in MT(1)- but not in MT(2)-knockout mice.

13 ype mice, and by phenotyping bones of Rhbdf2 knockout mice.

14 repetitive self-grooming phenotype in Shank3 knockout mice.

15 mTOR, or Rheb, rescues HSC defects in Sel1L knockout mice.

16 d in the plasma of one or the other of these knockout mice.

17 were absent in endothelial cells from TRPV1-knockout mice.

18 wild type C57BL/6jRj (B6) compared with TLR3 knockout mice.

19 or-negative intercalated cells from the same knockout mice.

20 and characterized a cohort of 20 lncRNA loci knockout mice.

21 the impact of a high-fat diet (HFD) on Abcc8 knockout mice.

22 calcitol-treated, vitamin D deficient or VDR knockout mice.

23 different tissue-specific Wnt10a conditional knockout mice.

24 hippocampal long-term potentiation in Sumo2 knockout mice.

25 ear factor erythroid 2-related factor (Nrf2) knockout mice.

26 r in the double-knockout mice than in Kir4.1 knockout mice.

27 e infectious to interferon-gamma (IFN-gamma) knockout mice.

28 impairment in conditional alpha2-Na/K ATPase knockout mice.

29 gnificantly attenuated in conditional Nav1.6 knockout mice.

30 owing intranasal instillation of H1N1 in Rag knockout mice.

31 ogical evidence of PAH in hematopoietic Tet2-knockout mice.

32 mineralocorticoid receptor expression in the knockout mice.

33 stration of carbon tetrachloride), and CPEB4-knockout mice.

34 is observed on brain slices taken from CLC-2 knockout mice.

35 ulated in intestinal stem cell-specific Tsc1 knockout mice.

36 ession model of migraine aura in conditional knockout mice.

37 ribution to itch by analysing Na(V)-specific knockout mice.

38 olished in hepatocyte-specific IL-6 receptor knockout mice.

39 ted cell-specific mineralocorticoid receptor knockout mice.

40 observed in liver- or muscle-specific Kbtbd2 knockout mice.

41 al system synaptic refinement deficits of C4 knockout mice.

42 in the glial cells or vasculature of Jedi-1 knockout mice.

43 he sedative effects of alcohol in male NBCn1 knockout mice.

44 nsgenic reconstitution of SULT1E1 in Sult1e1 knockout mice abolished the protection in male mice but

45 revious study reported that adiponectin gene knockout mice (Adipoq (-/-) ) develop GDM due to insulin

46 roliferation is less prominent in galectin-8-knockout mice after intradermal IL-23 treatment than in

47 ney fibrosis in normal mice but not in OASIS knockout mice after UUO, signifying Bst2 functions downs

48 emonstrate that antibody 13G8 protects STAT1-knockout mice against heterologous CCHFV challenge using

49 As expected, AIM2 knockout mice also demonstrated significant resistance t

50 ses in NEX-Cre lineage in double conditional knockout mice also generates similar tumours, which are

51 CD137 knockout mice also showed enhanced cold resistance.

52 Similarly, Prkch Treg-specific conditional knockout mice also showed improved viral clearance and d

53 Using conditional CDK5 knockout mice and a mouse model of highly metastatic mel

54 To address this, we generated Siglec-15 knockout mice and analyzed them in a mouse arthritis mod

55 in vivo or in vitro, as assessed with alpha7-knockout mice and by performing alpha-bungarotoxin (alph

56 Organoids from colon cells of CRT-knockout mice and control mice were analyzed by qRT-PCR,

57 s, glomeruli from podocyte-specific beta-PIX knockout mice and cultured mouse podocytes with beta-PIX

58 Using VSMC-selective Tfeb knockout mice and different mouse AAA models, we determi

59 We used endothelium-specific knockout mice and high-fat diet-fed mice to assess the r

60 odilatation in endothelial cell-specific CSE knockout mice and in a small collective of patients with

61 y electroencephalogram and behavior in GluA1 knockout mice and in transgenic mice with selective knoc

62 al mouse cochlea and compared SGNs in Pou3f4 knockout mice and littermate controls.

63 /+);LSL-Trp53(R172H/+) (KPC) mice with CDH11-knockout mice and measured survival times of offspring.

64 otonin and histamine was attenuated in Trpc4-knockout mice and ML204-treated mice.

65 ponses to live Mycoplasma pneumoniae in SP-A knockout mice and RAW 264.7 cells.

66 induced extensive atherosclerosis in miR-144 knockout mice and was accompanied by severe fatty liver

67 kout mice (NOX4betaKO) (though not from NOX2 knockout mice) and from NOX4-silenced or catalase-overex

68 ee similar to that of kidney-specific Kir4.1 knockout mice), and depolarization of the DCT membrane.

69 formed small-RNA sequencing on liver of Tsc1-knockout mice, and found that miRNAs of the delta-like h

70 f the male phenotype in Usp9x brain-specific knockout mice, and further resolve loss of hippocampal-d

71 nd in pancreatic cells from KPC and KPC-ZEB1-knockout mice, and pancreatic spheroids were established

72 subcellular distribution in wild-type mice, knockout mice, and receptor-positive and receptor-negati

73 We subjected wild-type mice, Sult1e1 knockout mice, and Sult1e1 knockout mice with liver-spec

74 Utilizing AnxA6 knockout mice (AnxA6(-/-) ), we challenged liver functio

75 Furthermore, our data suggest that AANAT knockout mice are a model of accelerated aging.

76 and energy metabolism, we show that PHOSPHO1 knockout mice are cold-tolerant, with higher expression

77 UNC80 knockout mice are neonatal lethal.

78 Furthermore, Vcpip1 knockout mice are prone to genomic instability and prema

79 The phenotypes of GSK3alpha and PP2B knockout mice are similar, prompting us to examine the i

80 entified candidate miRNAs derived from FKBP5 knockout mice as a potential diagnostic biomarker of PTS

81 th muscle-specific acid ceramidase (Ac) gene knockout mice (Asah1(fl/fl)/SM(Cre)) were used to demons

82 sure was similar between wild-type and CXCR6 knockout mice at baseline and after treatment with DOCA/

83 s by in vivo delivery of sevelamer to WD-fed knockout mice attenuated colonic mucosal inflammation an

84 In collecting ducts in CFTR knockout mice, baseline pendrin activity was significant

85 usion from Apom transgenic mice but not Apom knockout mice blocked fibrosis in the lung.

86 Unexpectedly, in Bmal1 knockout mice, both tissues exhibited 24-hour oscillatio

87 and Cortical layer V of the Epm2a or Nhlrc1 knockout mice brain.

88 ory cell infiltration was initially lower in knockout mice but later increased, leading to an accumul

89 pecific ARHGEF7 (commonly known as beta-PIX) knockout mice by crossing beta-PIX floxed mice with Podo

90 Here, we generated conditional SMAD7 knockout mice by crossing insulin1(Cre) mice with SMAD7(

91 Atherosclerosis was induced in miR-144 knockout mice by high fat diet and vascular lesions were

92 were induced in wild-type and P2y(2)r (-/-) knockout mice by intraperitoneal diethylnitrosamine (DEN

93 IL-10 or IL-10 receptor alpha (IL-10Ralpha) knockout mice by means of repeated intranasal administra

94 ability and phenotyping screens performed on knockout mice by the International Mouse Phenotyping Con

95 We generated cardiomyocyte-specific CITED4 knockout mice (C4KO) and subjected them to an intensive

96 tion, we generated CD11c-specific E-cadherin knockout mice (CD11c-Ecad(del)).

97 d adiposity, and glucose intolerance in male knockout mice, characterized by decreased energy expendi

98 In blood from both knockout mice, collagen-dependent thrombus and fibrin fo

99 inuria were found in these podocyte-specific knockout mice compared with control genotype littermates

100 sence of [(3)H]soticlestat staining in CH24H-knockout mice compared with wild-type mice, indicating a

101 die at a very early embryonic stage, POLR3GL knockout mice complete embryonic development without not

102 ues vascular abnormalities observed in Lztr1 knockout mice Conclusions: Lztr1 deletion phenotypically

103 In a two-bottle free choice procedure, knockout mice consumed more alcohol than controls and co

104 out mice (Dot1l(AC) ), Dot1l and Edn1 double-knockout mice (DE(AC) ), and Edn1 connecting tubule/coll

105 in myeloid recruitment) or miR-210 WT; Rag1 knockout mice (deficient in lymphocytes).

106 kout mice parabiosed with miR-210 WT; Cx3cr1 knockout mice (deficient in myeloid recruitment) or miR-

107 Similar to UTX, KMT2D NCC knockout mice demonstrate hypoplasia with reductions in

108 EC Hif-2alpha-knockout mice demonstrated lower levels of HGF.

109 nued alleviation of hepatocellular injury in knockout mice despite ongoing carbon tetrachloride insul

110 ty, and further tumorigenesis so that LRPPRC knockout mice develop more and larger hepatocellular car

111 Mbnl1 129S1 knockout mice develop postnatal thymic hyperplasia with

112 After SU5416 exposure, EC Hif-2alpha-knockout mice developed more severe emphysema, whereas E

113 Podocyte-specific beta-PIX knockout mice developed progressive proteinuria and kidn

114 WD-fed knockout mice developed severe NASH, which was associate

115 dney tubule-specific beta-ENaC or alpha-ENaC knockout mice did not alter claudin-8 abundance.

116 Although analyses of Fgf8 conditional knockout mice did not reveal developmental phenotypes, t

117 Moreover, whereas POLR3G knockout mice die at a very early embryonic stage, POLR3

118 m DC patients and late generation telomerase knockout mice display lower nicotinamide adenine dinucle

119 Consequently, conditional D2R knockout mice displayed a significant reduction in diggi

120 ), Deptor(-/-)) and myeloid-specific Slc40a1 knockout mice displayed abnormal bone phenotypes.

121 al kidney tubule-specific ENaC gamma-subunit knockout mice displayed decreased claudin-8 expression,

122 AHR knockout HeLa cells and tissues from Ahr knockout mice displayed decreased sphingolipid content a

123 Gstm1 knockout mice displayed increased oxidative stress, kidn

124 Compared with wild-type mice, the double-knockout mice displayed inhibited expression of phosphor

125 efined that IL-4Ralpha(-/-)/IL-5(-/-) double-knockout mice displayed significant eosinophil deficienc

126 e/collecting duct-specific Dot1l conditional knockout mice (Dot1l(AC) ), Dot1l and Edn1 double-knocko

127 conditional Insr,Igf1r, and double receptor knockout mice driven by Pgr-Cre.

128 nase-2 protein levels were increased in Pkd1 knockout mice during high salt intake; administration of

129 integrity of forebrain mitochondria in Fmr1 knockout mice during the peak of synaptogenesis.

130 tubule/collecting duct-specific conditional knockout mice (Edn1(AC) ), under three experimental cond

131 e with a neocassette (Oliver Smithies ERbeta knockout mice [ERbeta(OS-/-)]), prompted us to create an

132 nes but was inactive in membranes from GPR88 knockout mice, even at a concentration of 100 muM.

133 ration of NSCs and neurogenesis seen in Ccn1 knockout mice eventually returned to normal, the expande

134 Here we show that Top3beta knockout mice exhibit behavioural phenotypes related to

135 In addition, Grip1 knockout mice exhibit impaired hippocampal LTP, as well

136 Lastly, beta-cell-selective D2R knockout mice exhibit marked postprandial hyperinsulinem

137 C3(-/-);SRPX2(-/Y) double-knockout mice exhibit phenotypes associated with C3(-/-)

138 The sciatic nerve of Ahr knockout mice exhibited both reduced ceramide content an

139 Compared with control mice, Pkd1 knockout mice exhibited reduced arterial pressure during

140 Macrophages from knockout mice exhibited reduced phagocytosis and enhance

141 Gpr27 knockout mice exhibited slightly worsened glucose tolera

142 s after ischemia-reperfusion injury, whereas knockout mice exhibited the opposite.

143 ier function, junctional adhesion molecule A knockout mice, F11r(-/-) .

144 tion of CB1, CB2, or GPR55 receptors in gene-knockout mice failed to alter BCP's action against cocai

145 (NKCC2) levels were greatly reduced in Pkd1 knockout mice fed a high salt diet compared with control

146 shed the improved tubular repair in GSK3beta knockout mice following AKI.

147 colonization in gamma interferon (IFN-gamma) knockout mice following intracolon inoculation.

148 Homozygous knockout mice for Adamts19 show aortic valve dysfunction

149 Knockout mice for the kisspeptin receptor, Kiss1r (Kiss1

150 In Cyp26b1 conditional knockout mice, formation of striolar/central zones is co

151 ) knockout were protected similarly to TRPV1-knockout mice from type 1 diabetes-induced endothelial d

152 43213, and were absent in MT(2) and 5-HT(2C) knockout mice, fully recapitulating previous in vitro da

153 Adipose-selective Tet1 knockout mice generated by using Fabp4-Cre improves cold

154 Neurons from knockout mice had a higher action potential threshold an

155 S100-knockout mice had alterations in their fecal microbiomes

156 TNC knockout mice had an altered eosinophil recruitment prof

157 scopic analysis showed that podocytes of the knockout mice had distinctive foot process effacement an

158 Tumors formed in WNT5A knockout mice had elevated cytotoxic T cells, increased

159 Knockout mice had increased hepatic inflammation, and IL

160 We have previously reported that Glrx knockout mice had increased protein S-glutathionylation

161 Functionally, lack of SerpinB2 in aged knockout mice had no effect on the magnitude of senescen

162 Intestinal tissues from neonatal S100-knockout mice had reduced levels of CX3CR1 protein, and

163 Curiously, B. pertussis-infected IFNAR1 knockout mice had wild-type levels of lung inflammatory

164 Double knockout mice have impaired oocyte development and ovula

165 Here, we show that CD157 knockout mice have low levels of circulating OT in cereb

166 In ST2 knockout mice, IL-33 and OVA induced airway hyperrespons

167 disease, deficient in innate lymphoid (Il2rg knockout mice [Il2rg (KO)]), adaptive immune (Rag1 knock

168 tary effects of the drug were lost in Parkin knockout mice, implicating Parkin-mediated mitophagy as

169 cle hypertrophy were lost in beta-arrestin 1 knockout mice, implying that arrestins, multifunctional

170 Using AQP3 knockout mice in a model of liver injury and fibrosis pr

171 Here, we use Rad51ap1-knockout mice in genetically engineered mouse models of

172 xis (KELIg) was administered to wild-type or knockout mice in the presence or absence of polyinosinic

173 minergic cells in vitro and infection of Rag knockout mice in vivo.

174 Transgenic knockout mice in which beta-cell D2R or D3R expression i

175 We generated conditional knockout mice in which brain AMPKalpha isoforms are sele

176 olished in acute brain slices of conditional knockout mice in which Synaptotagmin-1 is removed from d

177 To test this model, we studied conditional knockout mice in which the vast majority of dentate gran

178 ockout pairs were protected from PH, whereas knockout mice in WT-knockout pairs developed PH.

179 ally decreased in podocyte-specific beta-PIX knockout mice, indicating podocyte loss.

180 f IL-1R1 expression in nociceptors of IL-1R1-knockout mice induced pain behavior but did not affect j

181 MG53 knockout mice infected with influenza virus show compara

182 ly, mouse CMV (MCMV) replication in vimentin knockout mice is significantly reduced compared with con

183 , which also occurs in hepatocytes from AMPK knockout mice, is best explained by allosteric regulatio

184 nder basal conditions, myeloid-specific KLF2 knockout mice (K2KO) exhibit increased feeding and weigh

185 ts elimination in myeloid cell-specific L13a knockout mice (L13a KO) increased atherosclerosis suscep

186 Finally, BARP-knockout, but not NACHO-knockout mice lacked nicotine-induced antiallodynia, hig

187 nerated Langerin-specific and CD11c-specific knockout ((-/-)) mice lacking AhR, respectively, in LC a

188 because of perinatal lethality exhibited by knockout mice lacking all three APP family members.

189 Double-knockout mice lacking both Kir4.1/Kir5.1 and Nedd4-2 in

190 ective CB(2) agonist JWH133 in wild-type and knockout mice lacking CB(2) in neurons, monocytes or con

191 In C57BL/6 gene knockout mice lacking either functional TCRs or MHC clas

192 hancement was lost almost completely in gene knockout mice lacking either TCRs or MHC class II molecu

193 also used conditional kidney tubule-specific knockout mice lacking ENaC subunits to assess the ENaC's

194 Homozygous knockout mice lacking one of two KRAB-ZFP gene clusters

195 estions we generated a series of conditional knockout mice lacking one or both house-keeping Pi trans

196 bule-specific overexpression of periostin or knockout mice lacking periostin expression in the renal

197 to induce diabetes in wild-type C57BL/6 and knockout mice lacking the genes encoding G protein-coupl

198 The different phenotypes of the knockout mice likely reflect differential expression lev

199 Methods and Results: Using IL-10 knockout mice mimicking systemic inflammation condition,

200 In Gpr88 knockout mice, morphine-induced locomotor sensitization,

201 from PIs from NOX4-null, beta-cell-specific knockout mice (NOX4betaKO) (though not from NOX2 knockou

202 A6 in the progression of NPC disease, double-knockout mice (Npc1(-/-)/Anxa6(-/-)) were generated and

203 as examination of metabolomics data from Oat-knockout mice (Oat1 and Oat3KO) revealed considerable ov

204 Using epithelium-specific knockout mice of AC6, we demonstrated that AC6 knockout

205 nterstitial lung macrophages was observed in knockout mice of WT-knockout pairs.

206 uscle or adventitia, miR-210 was observed in knockout mice of WT-knockout pairs.

207 Fah(-/-) , Rag2(-/-) , and Il2rg(-/-) knockout mice on the nonobese diabetic (FRGN) background

208 Genetic deletion (ICAM-1 knockout mice) or siRNA-mediated knockdown of ICAM-1 in

209 Moreover, apolipoprotein E (Apoe)-knockout mice overexpressing VSMC-specific Aadac showed

210 or by 5/6 nephrectomy; we also used AhR(-/-) knockout mice overloaded with indoxyl sulfate in drinkin

211 and PH, miR-210 was undetectable in knockout-knockout mice pairs.

212 racrine miR-210 delivery, we studied miR-210 knockout mice parabiosed with miR-210 WT; Cx3cr1 knockou

213 l miRNAs showing altered expression in FKBP5 knockout mice play a potential role as epigenetic marker

214 In contrast to null knockout mice (Podxl(-/-)), which die shortly after birt

215 ndocardial Kruppel-like factor 2 in Adamts19 knockout mice precedes hemodynamic perturbation, showing

216 y showing that the genetic deficiency of AR (knockout mice) prevented alcohol-induced increase in har

217 Knockout mice provided new genetic tools to study inflam

218 ut mice [Il2rg (KO)]), adaptive immune (Rag1 knockout mice [Rag1 (KO)]), or both systems (Il2rg (KO)/

219 gulator of atherosclerotic burden in miR-144 knockout mice receiving a high fat diet.

220 in global adipose triglyceride lipase (ATGL) knockout mice reduced free PAHSA levels and uncovered a

221 However, treatment with SOD3 in SOD3 knockout mice rescued KLK-5-induced inflammatory cascade

222 In loss of righting reflex assessment, knockout mice revealed increased sensitivity to alcohol-

223 cross of the Sulf2-overexpressing with Gli1-knockout mice revealed that Gli1 inactivation impairs SU

224 Applying our approach to knockout mice revealed that Piezo2 differentially tunes

225 y blocked the formation of SCLC in Rb1/Trp53-knockout mice (RP mice).

226 duced leukemia, we crossed conditional Runx1 knockout mice (Runx1f/f) with conditional Cbfb-MYH11 kno

227 its associated basal lamina in Six1 and Six4 knockout mice (s1s4KO) at E18.

228 (SJ1(RQ)KI) exhibit PD features, while Sac2 knockout mice (Sac2KO) do not have obvious neurologic de

229 In Gal-3 knockout mice, scar thinning ratio, expansion, and cardi

230 A-sequencing studies of the SMC-specific Ahr knockout mice showed a significant increase in the propo

231 CH24H-knockout mice showed a substantially lower level of soti

232 Finally, Irs2 knockout mice showed an aberrant response to amphetamine

233 Endothelial-specific JunB knockout mice showed diminished expression of neurovascu

234 Knockout mice showed increased propensity for alcohol-in

235 renal injury compared with controls, whereas knockout mice showed increased tubular injury and deteri

236 Interestingly, whole body P2Y(6)R knockout mice showed metabolic improvements similar to t

237 Kidneys from the Pkd1 knockout mice showed no apparent renal cysts, tubule dil

238 Nck1-knockout mice showed reduced endothelial activation and

239 Importantly, the observation that knockout mice showed significant amelioration of disease

240 nsfer of CD8(+) T cells from OT1 mice to CD8 knockout mice significantly reduced chlamydial induction

241 a reduction of prepulse inhibition in A(2A)R knockout mice, similar to that observed in the PCP anima

242 ase Sirt5 in MCT metabolism by feeding Sirt5 knockout mice (Sirt5KO) high-fat diets containing either

243 mechanisms involved were investigated using knockout mice, small molecule inhibitors/agonists, and g

244 Tet2-knockout mice spontaneously developed PAH, adverse pulmo

245 In both pairs, miR-210 knockout mice still displayed miR-210 delivery and PH, t

246 valent PCB congener in human tissues, on SXR knockout mice (SXRKO) and to elucidate the role of SXR i

247 expression/activity was higher in the double-knockout mice than in Kir4.1 knockout mice.

248 Wild-type and Pkd2/Ift88 double-knockout mice that are protected from cyst growth served

249 We generated Capn15 knockout mice that exhibited similar severe developmenta

250 ns in L-DOPA induced dyskinesia, we used D5R knockout mice that were rendered parkinsonian by unilate

251 In IL-33 knockout mice, the IL-33- and OVA-induced airway hyperre

252 Using conditional knockout mice, they demonstrate that talin1 promotes the

253 urons (iMSNs) in the ventral striatum of D2R knockout mice, this mutant restored basal locomotor acti

254 re, we generated inducible, EC-specific Pkd2 knockout mice to examine vascular functions of PKD2.

255 chemistry in brains of wild-type and Drebrin knockout mice to in vitro analyses of impaired synapse f

256 We also used knockout mice to investigate the role of TNF receptors 1

257 We subjected SerpinB2 knockout mice to ischemia-reperfusion injury or unilater

258 DNA into wild-type and CCR6-deficient (CCR6-knockout) mice to induce overexpression of IL-23 systemi

259 In endothelial cell-specific Bmpr2-knockout mice unable to stabilize p53 in endothelial cel

260 Gprc5b-KO (tamoxifen-inducible, SMC-specific knockout) mice under conditions of arterial hypertension

261 ates hepatic ER stress response, whereas VDR knockout mice undergo persistent UPR activation and apop

262 PNLIP-knockout mice, unlike ATGL knockouts, were protected fro

263 During pancreatitis, obese PNLIP-knockout mice, unlike obese adipocyte-specific ATGL knoc

264 In forebrain-specific Usp9X knockout mice (Usp9X(-/Y)), ankyrin-G as well as multipl

265 Exacerbated viral pathogenesis in Ly6e knockout mice was accompanied by loss of hepatic immune

266 , the natural evolution of fibrosis in Gal-3 knockout mice was also affected.

267 specific 35% nephron deficit in microRNA-210 knockout mice was observed.

268 e cerebellar structural abnormality in Cdkl5 knockout mice, was found in regions of high transgene ex

269 d after birth, similar to Nppa-Nppb compound knockout mice we generated.

270 Moreover, in AIM2 knockout mice we observed attenuated inflammasome-mediat

271 single-cell analysis of Sox13, Maf, and Rorc knockout mice, we demonstrate sequential activation of t

272 By examining Fat4 and Dchs1 knockout mice, we demonstrate their critical roles in vi

273 EC cell lines and colonoids derived from CRT-knockout mice, we found that CRT regulates energy balanc

274 Studying NPY-knockout mice, we found that NPY deficiency in vivo surp

275 l type-conditional TGFbeta receptor I (ALK5) knockout mice, we interrogate this mechanism.

276 , siRNA-mediated gene silencing, RT-PCR, and knockout mice, we investigated whether IQGAP1 modulates

277 By studying knockout mice, we provide evidence that CD8(+) T cells a

278 Using miR-210 replete (wild-type [WT]) and knockout mice, we tracked blood-borne miR-210 using bone

279 wild-type and cardiomyocyte-restricted FoxO1 knockout mice, we unveil an essential role for the FoxO1

280 S100-knockout mice weighed 21% more than wild-type mice at ag

281 natriuresis during high salt loading in Pkd1 knockout mice were associated with lower urinary nitrite

282 Gpr27 knockout mice were born at expected Mendelian ratios and

283 TMIGD1 knockout mice were developed, and the loss of TMIGD1 in

284 Wild-type, IL-33 knockout, ST2 knockout mice were either intratracheally administrated

285 Moreover, PKCe-knockout mice were found to be less susceptible to lung

286 In addition, non-CKD AhR(-/-) knockout mice were protected against indoxyl sulfate-ind

287 Furthermore, IRAK1 knockout mice were protected from LPS-induced PTB, which

288 CCR6-knockout mice were resistant to IL-23-induced skin infla

289 within the medial prefrontal cortex of FKBP5 knockout mice were selected.

290 ollowing uninephrectomy, wild-type and CXCR6 knockout mice were treated with DOCA/salt for 3 weeks.

291 encyclidine (PCP) mouse model and the A(2A)R knockout mice, were used to establish correlations betwe

292 and behavioral deficits in Mecp2 conditional knockout mice, whereas about 12-fold decrease in Wnt6 mR

293 intestinal tissues from wild-type and Atoh1-knockout mice, which have expansion of tuft cells, to st

294 Incubation of organoids derived from double-knockout mice with acetate or dichloroacetate restored s

295 erbated lung inflammatory pathology, whereas knockout mice with defects in type I IFN signaling had l

296 To test this hypothesis, we used conditional knockout mice with DORs deleted from forebrain GABAergic

297 f Lsh in hematopoiesis using conditional Lsh knockout mice with expression of Mx1 or Vav Cre-recombin

298 ype mice, Sult1e1 knockout mice, and Sult1e1 knockout mice with liver-specific reconstitution of SULT

299 In VDR knockout mice with renal injury, paricalcitol prevented

300 dismutase mimetic, rescued kidney injury in knockout mice without lowering BP.