ライフサイエンスコーパス: knockout mouse

1 nalyzed the first, to our knowledge, ATG16L2 knockout mouse.

2 ensory cortex of a FXS mouse model, the FMR1 knockout mouse.

3 al development, we established a novel Egfl7 knockout mouse.

4 al phenotype similar to that of the Atpbv1b1 knockout mouse.

5 ment in the low-density lipoprotein receptor knockout mouse.

6 lium using a conditional epithelium-specific knockout mouse.

7 vo as shown by ex vivo analysis of a NeuroD2 knockout mouse.

8 ns of TSPO, we first developed a viable TSPO knockout mouse.

9 OB) in the brain of wild-type but not Sig-1R knockout mouse.

10 y were investigated in retinas of the Ndufs4 knockout mouse.

11 neonatal lethal argininosuccinate synthetase knockout mouse.

12 mechanisms causing XLRP, we generated an RP2 knockout mouse.

13 vo function of TRPML2, we generated a TRPML2-knockout mouse.

14 ptozotocin-induced diabetic apolipoprotein E-knockout mouse.

15 , we created a CRISPR/Cas9-mediated Snord115 knockout mouse.

16 nt was evaluated using a global microRNA-210 knockout mouse.

17 ignalling defects in the Tmem67(tm1(Dgen)/H) knockout mouse.

18 ftment and on liver repopulation in the mdr2-knockout mouse, a model for progressive familial intrahe

19 e use of a conditional, cardiac-specific G9a knockout mouse, a specific G9a inhibitor, and high-throu

20 and a conditional hepatocyte-specific AEG-1 knockout mouse (AEG-1(DeltaHEP) ).

21 ession in the urothelium of the female Foxa1 knockout mouse and an increase in the expression of a nu

22 o, we generated a pericyte-specific miR-145a-knockout mouse and determined sepsis-induced organ injur

23 Here, we generated a Katna1 knockout mouse and found that consistent with a critical

24 eration and migration were reduced in Hhipl1 knockout mouse and HHIPL1 knockdown aortic smooth muscle

25 Here, we generated a PRCD knockout mouse and observed a striking defect in disc mo

26 a novel intestinal epithelial-specific IDO1 knockout mouse and utilized established colorectal cance

27 consistent with those observed in the Nrros knockout mouse, and they overlap with those seen in the

28 e severe inflammatory response in AMPKalpha2 knockout mouse aortas, all of which were suppressed by c

29 ific inactivation of Inpp5b on a global Ocrl-knockout mouse background resulted in low molecular weig

30 ave generated a new beta-catenin conditional knockout mouse (beta-cat cKO) with targeted depletion of

31 al muscle similar to those seen in the Bmal1 knockout mouse (Bmal1(-/-) ), a model of advanced ageing

32 m relative to the nucleus is altered in Fmr1 knockout mouse brain cortex.

33 in wild-type and cholesterol 24S-hydroxylase knockout mouse brain.

34 Morphological analysis of the Svbp knockout mouse brains by anatomical magnetic resonance i

35 CHARGE patient-derived iPSCs and conditional knockout mouse brains.

36 e defect in secretory activation in the cSrc knockout mouse, but most importantly, the activity of cS

37 lly after depletion of OCT2 in a conditional knockout mouse, but their proliferation is reduced and i

38 ta(OS-/-)]), prompted us to create an ERbeta knockout mouse by deleting the ERbeta gene with the use

39 phenotype in a mouse model of LGMD R1 (CAPN3 knockout mouse-C3KO) was studied.

40 The transcobalamin receptor-knockout mouse ( Cd320(-/-)) develops cobalamin (Cbl) de

41 The immunogen was created in an ADAM10-knockout mouse cell line stably overexpressing human Tsp

42 trial-specific Na(+) /Ca(2+) exchanger (NCX) knockout mouse, cellular Ca(2+) accumulation during spon

43 The International Knockout Mouse Consortium (IKMC) has produced a genome-w

44 The International Knockout Mouse Consortium (IKMC) introduces its targeted

45 ilding upon resources from the International Knockout Mouse Consortium (IKMC), we developed a targeti

46 Our conditional Tshz3 knockout mouse constitutes a novel ASD model, opening th

47 cytes, we generated a podocyte-specific Coq6 knockout mouse (Coq6(podKO) ) model and a transient siRN

48 reduced and patchy on IL-1 receptor (IL-1R)-knockout mouse corneas (P < 0.05, ANOVA).

49 phenotype of estrogen receptor beta (ERbeta) knockout mouse, created by removing the DNA-binding doma

50 ceptor homeostasis in vivo by using an Erdj5 knockout mouse crossed with the P23H knock-in mouse and

51 an disease data sets and 121 samples from 11 knockout mouse data sets.

52 e developed a new endothelium-specific DDAH1 knockout mouse (DDAH1(En-/-)) to investigate the signifi

53 A rod-specific Kif3/Kif17 double knockout mouse demonstrated that KIF17 and KIF3 do not a

54 ed in monocytes from WAS patients and in WAS-knockout mouse dendritic cells.

55 g a Chrnb4-cre; Dicer(flox/flox) conditional knockout mouse (Dicer CKO) to delete Dicer1 from cone ce

56 is corroborated by the existence of a Tenm4 knockout mouse displaying an ET phenotype, implicates TE

57 hat PB2 associates with mitochondria in MAVS knockout mouse embryo fibroblasts.

58 ian period in a Cry1 (-/-) Cry2 (-/-) double knockout mouse embryonic fibroblast cell line.

59 om histone H3 K36 trimethyltransferase SETD2 knockout mouse embryonic fibroblasts (MEF) cells.

60 d RNA sequencing on wild-type and beta-actin knockout mouse embryonic fibroblasts (MEFs) after reprog

61 derived from affected individuals and Cdk10-knockout mouse embryonic fibroblasts (MEFs) proliferated

62 titers of infectious EBOV derived from SOCS3 knockout mouse embryonic fibroblasts (MEFs) were signifi

63 Using knockout mouse embryonic fibroblasts (MEFs), we demonstr

64 Using knockout mouse embryonic fibroblasts we show that Miro1

65 ed into BAX/BCL2 agonist killer (BAK) double-knockout mouse embryonic fibroblasts, its location was s

66 Additionally, we show that in kindlin-2 knockout mouse embryonic fibroblasts, overactivation of

67 the genomic key feature of Tet1/Tet2 double-knockout mouse embryonic fibroblasts.

68 e DNA repair and checkpoint defects in Palb2 knockout mouse embryonic stem (mES) cells, we identify v

69 rentiation assays reveal that Dppa2/4 double knockout mouse embryonic stem cells fail to exit pluripo

70 Rescue experiments in Dnmt3a/3b double knockout mouse embryonic stem cells show that the corres

71 uced into otherwise microRNA-deficient Dgcr8 knockout mouse embryonic stem cells.

72 Moreover, we found that Fkbp8 knockout mouse embryos have abnormal expression of Wnt3a

73 tions in MO-mediated gene knockdown frog and knockout mouse embryos unearthed PCP/CE-related phenotyp

74 In VDR knockout mouse epithelial cells (KO), 1,25(OH)2D3 increa

75 A proximal tubule-specific TFEB-knockout mouse exhibited progression of kidney injury in

76 Unlike the original knockout mouse, expression of Ki67, androgen receptor, a

77 ss this question by generating a conditional knockout mouse for Dpy30, which is a common core subunit

78 in dominance behavior by using a conditional knockout mouse for G protein subunit Galphai2, which is

79 ion and remyelination, we used a conditional knockout mouse for VGCCs in OPCs.

80 alysis, Roxadustat rescued the hepatic HIF-1 knockout mouse from retinal oxygen toxicity, whereas DMO

81 ed with loss of REEP6 function using a Reep6 knockout mouse generated by CRISPR/Cas9 gene editing.

82 rotein 1 (UCP1), the development of the UCP1 knockout mouse has enabled the study of possible UCP1-in

83 The phenotype of the Dazl knockout mouse has extensive germ cell loss because of i

84 issue in a previously uncharacterised Hdac11 knockout mouse (Hdac11 (KO/KO)).

85 pression of catalase, in vivo, restored ATF6 knockout mouse heart function to wild-type levels in a m

86 wild-type and S-nitrosoglutathione reductase knockout mouse hearts (S-nitrosoglutathione reductase is

87 Conversely, Snrk knockout mouse hearts have increased glucose and palmita

88 r nonstressed conditions, wild-type and ATF6 knockout mouse hearts were similar.

89 generated a muscle-specific inducible Depdc5 knockout mouse, hypothesizing that knocking out Depdc5 i

90 and development by generating a conditional knockout mouse in which the protein is depleted from mus

91 of generic Wnt/beta-catenin targets in Rab8a knockout mouse intestinal crypts indicate reduced signal

92 here the gene of interest is essential and a knockout mouse is not available.

93 phenotype is replicated in the jam2 complete knockout mouse (jam2 KO).

94 s a protective genetic modifier in the Kcna1 knockout mouse (Kcna1-/-) model of SUDEP, while searchin

95 eoxyguanosine levels increased in both Aldh2-knockout mouse keratinocytes and ALDH2-knockdown human k

96 showed in cultured mammalian cells and Pkd1 knockout mouse kidney epithelial cells that PC1 and its

97 Triple-knockout mouse lacking expression of eNOS, Cav1, and Ldl

98 ion of new discs, we generated a conditional knockout mouse lacking its essential ArpC3 subunit in ro

99 both intact wildtype and M2 or M1/3-receptor knockout mouse Langendorff hearts, atropine led to incre

100 A knockout mouse line (BC(-/-)) was generated and demonstr

101 ral analysis of the resulting Nestin-Cre-Lpd knockout mouse line revealed a specific behavioural phen

102 We generated a Gstm1 knockout mouse line to study its role in a CKD model (in

103 Using an inducible, EC-specific Panx1 knockout mouse line, we report a previously unidentified

104 Using a conditional knockout mouse line, we report that loss of pericytic la

105 Here, by utilizing a conditional knockout mouse line, we report that PDGFRbeta(+) cell-de

106 SUMO2 and generated a new conditional Sumo2 knockout mouse line.

107 re carried out in a podocyte-specific Gprc5b knockout mouse line.

108 d the R6/2 HD model with the long-lived S6k1 knockout mouse line.

109 A DKO (dual knockout) mouse line with deficiencies in CrAT (carnitin

110 g the newly developed tissue-specific Nell-1 knockout mouse lines in addition to the existing transge

111 Sod1(G86R) and Fezf2 knockout mouse lines were crossed to generate a model th

112 , a conditional Ctgf myofiber and fibroblast-knockout mouse lines were generated and crossed to a dys

113 nerate and phenotypically characterize 5,000 knockout mouse lines, here we identify 410 lethal genes

114 we generated and analyzed three conditional knockout mouse lines, in which the essential PRC2 subuni

115 present evidence, in two different CK2alpha knockout mouse lines, that this regulation is region-spe

116 ng a series of Cre-transgenic, reporter, and knockout mouse lines, we demonstrate that BCL6 deficienc

117 SUMOylation-deficient-Sf1(2KR/2KR) and Dax1 knockout mouse lines, with FAdE expression/activity reta

118 umulation and reduces tumorigenesis in Brca1-knockout mouse mammary epithelium.

119 the structural remodeling of the DCT in the knockout mouse may not be a direct consequence of aberra

120 tegy to generate the whole body dematin gene knockout mouse model (FLKO).

121 validate our discovery, we generated a Kdm5a knockout mouse model (Kdm5a(-/-)) and confirmed that ina

122 egated structures in the cerebellum of Mecp2 knockout mouse model (Mecp2 (-/y) ) during transition fr

123 Using a PSD-95 knockout mouse model (PSD-95(-/-)), we examined how PSD-

124 and Myrcludex B binding in the first Slc10a1-knockout mouse model (Slc10a1 encodes NTCP).

125 A knockout mouse model allows dissociation of the coordina

126 adult HSCs, we generated a novel conditional knockout mouse model and deleted Prdm16 in adult mouse h

127 F1 mutations, we investigated a heterozygous knockout mouse model and found that this model recapitul

128 specific for Rem2 was validated using a Rem2 knockout mouse model and used to show abundant expressio

129 fen-inducible and endothelial-specific Stat3 knockout mouse model by crossbreeding Stat3(floxed/KO) a

130 iction in an angiotensin-converting enzyme 2 knockout mouse model characterized by placental hypoxia.

131 re, we generate a brain specific conditional knockout mouse model deficient for Pogz, an ASD risk gen

132 An endothelium-specific Tfeb-knockout mouse model displays defects in fetal and newbo

133 Here, we explored the role of Olfml3 in a knockout mouse model engineered to suppress this protein

134 e-colony stimulating factor (G-CSF) receptor knockout mouse model in combination with bone marrow cel

135 The knockout mouse model in combination with sophisticated m

136 We generated a conditional Psip1 knockout mouse model in the hematopoietic compartment an

137 Thus, the Ezh2 conditional knockout mouse model may be useful to explore mechanisms

138 In a knockout mouse model of Alix, we identified overt struct

139 Here, we generated a knockout mouse model of Anks6 and show that ANKS6 functi

140 scope in an SMC-specific lineage-tracing Ahr knockout mouse model of atherosclerosis to better unders

141 than CDME, and 1b was effective in vivo in a knockout mouse model of cystinuria.

142 pose that our intestine-specific ferroportin knockout mouse model of end-stage IDA could be used in f

143 In the Fmr1 knockout mouse model of FXS, the maturation of synapses

144 iorate disease pathology in a laminin-alpha2 knockout mouse model of muscular dystrophy, acting as a

145 1 is elevated in the cortex in the Nrg1(+/-) knockout mouse model of schizophrenia (SZ).

146 -mPFC projection is hyperactive in the Mecp2 knockout mouse model of the autism spectrum disorder Ret

147 Here, we describe a complete knockout mouse model of the autism-associated Shank3 gen

148 stric monocyte infiltration using the Cx3cr1 knockout mouse model prevented SPEM development.

149 We report here that the Ptrh2 knockout mouse model recapitulates the progressive conge

150 Study of an available knockout mouse model showed that the mutant mice display

151 The Slc10a1-knockout mouse model supports the central role of NTCP i

152 Our recently generated Vgat endothelial cell knockout mouse model that blocks GABA release from endot

153 In this study, we generated an AFAP1 knockout mouse model that establishes a novel physiologi

154 ng inflammaging, we used a Foxn1 conditional knockout mouse model that induces accelerated thymic inv

155 andidate gene was identified, we generated a knockout mouse model that manifested the phenotype and s

156 viously generated an Ikbkap/Elp1 conditional-knockout mouse model that recapitulates the selective de

157 e used a pan-DC, CD11c-specific cre-lox gene knockout mouse model to assess the role of KLF2 in DC ac

158 Methods: Here, we used a GLP-1R knockout mouse model to demonstrate that exocrine bindin

159 We created a Ewsr1 conditional knockout mouse model to deplete EWSR1 before the onset o

160 nhibitor [Formula: see text] kinase 2 (IKK2) knockout mouse model to determine the role of pulmonary

161 We used a knockout mouse model to functionally validate MMP10's ro

162 transducer and activator of transcription 3 knockout mouse model to investigate the effect of abroga

163 uman tissue and generated a cardiac-specific knockout mouse model to investigate the functional impac

164 In this study, we used a conditional knockout mouse model to investigate the role of Smarca5,

165 his problem, we have used a WASH conditional knockout mouse model to investigate the role of WASH in

166 muscle function, we developed a conditional knockout mouse model to specifically delete Rbfox1 in ad

167 Here, we have used an Hhex inducible knockout mouse model to study the role of Hhex in adult

168 We developed an Mrkn2 knockout mouse model to study the role of this gene, and

169 We used an inducible beta-cell knockout mouse model to test the hypothesis that Sox4 is

170 We generated a miR-193b knockout mouse model to unravel the physiological functi

171 ss EAC development, we created a conditional knockout mouse model using progesterone receptor-Cre-rec

172 We used skeletal muscle-specific Cpt1b knockout mouse model where the inhibition of mitochondri

173 The existence of a conditional-Mylk-knockout mouse model with severe gut dysmotility and abn

174 using a newly developed paxillin conditional knockout mouse model with targeted ablation in the mamma

175 ethality of the only published global Slc7a7 knockout mouse model, a viable animal model to investiga

176 r findings suggest that in a tissue-specific knockout mouse model, an IKK2-dependent pulmonary inflam

177 rally controlled neuron-specific conditional knockout mouse model, recapitulated cellular and cogniti

178 nd skeletal anomalies in a heterozygous Bmp2-knockout mouse model, suggesting that haploinsufficiency

179 Using an inducible knockout mouse model, we characterise an essential role

180 Furthermore, through the use of a knockout mouse model, we demonstrate for the first time

181 Using a knockout mouse model, we demonstrate that loss of microR

182 Using a gene-knockout mouse model, we demonstrate that the administra

183 scle-specific ring finger protein-1 (MuRF-1) knockout mouse model, we evaluated the role of the ubiqu

184 rthermore, by generating a TC10/Cdc42 double knockout mouse model, we found that TC10 can compensate

185 Thus, using a new knockout mouse model, we have identified Hic-5 expressio

186 ystems, CRISPR-Cas9-mediated knockout, and a knockout mouse model, we investigated the antiviral capa

187 In this study, using a knockout mouse model, we show that the transcription fac

188 We have developed a double knockout mouse model, which also shows reduced muscle st

189 A conditional Neb knockout mouse model, which recapitulates thin filament

190 the pathogenesis of KIN, we generated a Fan1 knockout mouse model, with abrogation of Fan1 expression

191 Using an in vivo Ifnar1(-/-) knockout mouse model, ZIKV infection was found to reduce

192 rst existence and characterization of a Mct6 knockout mouse model.

193 in gastric tumors from the trefoil factor 1-knockout mouse model.

194 by utilizing a photoreceptor-specific, PKM2 knockout mouse model.

195 cess in the hepatic conditional beta-catenin knockout mouse model.

196 cell development by generating a conditional knockout mouse model.

197 sive dystrophic epidermolysis bullosa (RDEB) knockout mouse model.

198 ent, we studied a previously generated Abcd3 knockout mouse model.

199 y was significantly upregulated in the Olfm4-knockout mouse model.

200 generated and analyzed a conditional C9orf72 knockout mouse model.

201 our affected Kelpies has been observed in a knockout mouse model.

202 screen on an inducible podocyte-specific WT1 knockout mouse model.

203 een shown to cause a severe hepatopathy in a knockout mouse model.

204 ed the photoreceptors of a heterozygous Opa1 knockout mouse model.

205 ction on the mammalian brain, we generated a knockout mouse model.

206 in a conditional and adipocyte-specific p53 knockout mouse model.

207 homeostasis using a hepatocyte-specific p53 knockout mouse model.

208 inst heterologous CCHFV challenge in a STAT1-knockout mouse model.

209 RF for CRPC growth in Pten/Trp53 conditional knockout mouse model.

210 d an inducible, cardiomyocyte-specific SRSF3 knockout mouse model.

211 es from PKP2 heterozygous and DP conditional knockout mouse models also exhibit elevated TGF-beta1/p3

212 te of TA proteins in two tissue-specific WRB knockout mouse models and found that their dependence on

213 With the development of knockout mouse models and molecular inhibitors unique to

214 Here, we used knockout mouse models and time-lapse microscopy to eluci

215 The combination of conditional knockout mouse models and viral vector-mediated autophag

216 as9-based genome editing can easily generate knockout mouse models by disrupting the gene sequence, b

217 In knockout mouse models for estrogen receptor or aromatase

218 Knockout mouse models for HDACs 1-9 have been important

219 The recent use of Ifit knockout mouse models has revealed novel antiviral funct

220 Knockout mouse models have been extensively used to stud

221 Amtn overexpression and Amtn knockout mouse models have defective enamel with no othe

222 function of S1P, we generated brain-specific knockout mouse models in which S1P-lyase (SPL), the enzy

223 Furthermore, neonatal and interferon gamma knockout mouse models of C. parvum infection identified

224 was tested by generating tamoxifen-inducible knockout mouse models of Cyp26b1 alone or with Cyp26a1.

225 and human APOBEC3 proteins in transgenic and knockout mouse models of viral infection suggest that th

226 Our study using knockout mouse models provides convincing genetic eviden

227 However, studies of Mst1/2 knockout mouse models revealed that the identity of the

228 Knockout mouse models suggest that OSR1 mainly activates

229 We use conditional Numb- and Numbl-knockout mouse models to demonstrate that loss of Numb/N

230 ant overlap with several conditional uterine knockout mouse models, including Foxa2, Wnt4, and Sox17.

231 T1 knockdown in breast cancer cell lines and knockout mouse models, suggest the potential involvement

232 Using different Smad4 conditional knockout mouse models, we disrupted canonical TGFbeta/BM

233 Using transgenic and transplantable Rgnef knockout mouse models, we find that Rgnef is essential f

234 VHL complex coupled with conditional genetic knockout mouse models, we further discovered that the E3

235 By using conditional knockout mouse models, we investigated the specific role

236 zygous BRD7 knockout and liver-specific BRD7 knockout mouse models, we report that reduced BRD7 level

237 Using miR-26a knockin and knockout mouse models, we showed that miR-26a in beta ce

238 t5a(-/-) and Nestin-Cre mediated conditional knockout mouse models.

239 both early- and later-stage Pkd1 conditional knockout mouse models.

240 were required as inferred from studies using knockout mouse models.

241 SRSF2 in hematopoiesis by using conditional knockout mouse models.

242 This effect persisted in FFAR2/3-knockout mouse monocytes and was not reproduced by synth

243 iased computational modeling of B56alpha KO (knockout) mouse myocyte action potentials revealed an un

244 sing an N-cadherin lens-specific conditional knockout mouse, N-cad(Deltalens), show that loss of this

245 ng a conditional nociceptor-specific NaV 1.7 knockout mouse (NaV 1.7(Nav1.8) ) and selective small-mo

246 pecific inositol 3-phosphate receptor type-2 knockout mouse, near-infrared light-induced Ca(2+) micro

247 JIP3 knockout mouse neuron primary cultures accumulate lysoso

248 lecular substitution of human PTEN into Pten knockout mouse neurons and assessed neuronal morphology

249 The Sec63-Xbp1 double knockout mouse offers a novel genetic model of chronic t

250 We bred an Adamts7 whole-body knockout mouse onto both the Ldlr and Apoe knockout hype

251 We generated an M-opsin knockout mouse (Opn1mw (-/-)) expressing only S-opsin as

252 by impaired glutathione synthesis, the Gclm knockout mouse, oxidative stress activated MMP9 (matrix

253 ated an inducible type II cell-specific p120-knockout mouse (p120EKO).

254 Interrogation of knockout mouse phenotype resources provides a further av

255 orter gene (lacZ) in the vector used for the Knockout Mouse Project (KOMP) is driven by the endogenou

256 92 lacZ reporter lines available through the Knockout Mouse Project.

257 EAF2 knockout mouse prostate was also sensitized to gamma-irr

258 ound that a proximal tubules-specific DsbA-L knockout mouse (PT-DsbA-L-KO) attenuated UUO-induced TIF

259 neered a myocardial-restricted inducible RAD-knockout mouse (RAD(Delta/Delta)).

260 racellular ionic permeabilities in the Ildr1 knockout mouse renal tubules are not affected.

261 of cystinosis are limited, with only a Ctns knockout mouse reported, showing cystine accumulation an

262 how that loss of Caspr2 in the Cntnap2 (-/-) knockout mouse results in impaired Purkinje cell dendrit

263 of IRE1alpha and Xbp1 mRNA splicing in TLR2 knockout mouse retina.

264 Rbfox1 gene to autism, and a brain-specific knockout mouse revealed a critical role for this splicin

265 ucer and activator of transcription (STAT)-1 knockout mouse showed that IFN-gamma signaling in kerati

266 ted at the transcriptional level in loricrin knockout mouse skin and confirm that late cornified enve

267 In the present study, we generated a knockout mouse strain (Asah1(fl/fl)/Podo(Cre)) with a po

268 By generating a beta-cell-specific Mcl-1 knockout mouse strain (betaMcl-1KO), we observed that, s

269 We generated a conditional triple-H1-knockout mouse strain and depleted H1 in haematopoietic

270 in EH in vivo we developed a new functional knockout mouse strain by deleting the pore domain of TRP

271 grown in a NOD/SCID IL2 receptor gamma (NOG) knockout mouse strain transgenic for human IL2.

272 GC B cells by crossing the Gna13 conditional knockout mouse strain with the GC-specific AID-Cre trans

273 Using two conditional knockout mouse strains and derived cells, we demonstrate

274 scriptomes and targeted metabolomics of five knockout mouse strains deficient in essential factors re

275 hose goal is to produce and phenotype 20,000 knockout mouse strains in a reproducible manner across t

276 In this study, we generated 2 knockout mouse strains that lacked pKal and HK and deter

277 talog of gene function by characterizing new knockout-mouse strains across diverse biological systems

278 Knockout mouse studies revealed that stromal, not neopla

279 Although FOXC1 knockout mouse studies showed that it is not required fo

280 the elaborate conditional and cell-specific knockout mouse studies that brought the role of this pat

281 und to limit early inflammatory pathology in knockout mouse studies.

282 sly, we generated and characterized a Trim32 knockout mouse (T32KO) that displays both neurogenic and

283 e original experiments in the beta-arrestin2-knockout mouse that led to this proposal, and alternativ

284 omyocyte-specific, tamoxifen-activated, PKP2 knockout mouse to demonstrate that in addition to its ro

285 an inducible, skeletal muscle-specific Dicer knockout mouse to deplete microRNAs in adult skeletal mu

286 We have produced the first H2A.B knockout mouse using the TALEN approach.

287 ntiation and function, an Ikaros conditional knockout mouse was developed such that Ikaros expression

288 Here, a CR-C knockout mouse was established to determine its role on

289 A conditional TSPO knockout mouse was generated by utilizing the Cre-Lox sy

290 For the first time, an EC-specific MIF knockout mouse was used to investigate the effects of se

291 Using a new conditional Cic knockout mouse, we demonstrate that forebrain-specific C

292 single-cell transcriptomics of a conditional knockout mouse, we demonstrate that Kat2a contributes to

293 last lines derived from an Arpc2 conditional knockout mouse, we established matched-pair cells with a

294 Here, making use of a newly generated Pdgfd knockout mouse, we reveal a functionally important malig

295 Using an isoform-specific knockout mouse, we show that hair cells expressing only

296 us infection, memory CD8 T cells in the CR-C knockout mouse were formed in greater numbers, were more

297 In contrast to the reported phenotype of the knockout mouse, which was developed on a primarily C57BL

298 ering to develop a SPAR-polypeptide-specific knockout mouse while maintaining expression of the host

299 his study, we used a subfield-specific GluN1 knockout mouse with a disease-like molecular perturbatio

300 bining a conditional GABA(A) alpha2 receptor knockout mouse with optogenetics.