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1 in precursor, an arrangement common to other knottins.
2  mice by small animal CT, and both 64Cu-DOTA-knottin 2.5F and FDG were able to differentiate lung nod
3   Collectively, these results show 64Cu-DOTA-knottin 2.5F to be a promising candidate for clinical tr
4     Ex vivo biodistribution showed 64Cu-DOTA-knottin 2.5F to have a fast renal clearance combined wit
5        Uptake and retention of the 64Cu-DOTA-knottin 2.5F tracer in the lung tumors combined with a l
6                  We thereby isolated variant knottins against cellulose (differing in sequence from t
7 ial peptides (e.g., defensins, thionins, and knottins), alkaloids, nonproteogenic amino acids, and ph
8 ulose (differing in sequence from the parent knottin) and also against alkaline phosphatase.
9                                              Knottins are a group of small, disulphide-bonded protein
10                             Similar to other knottins, cystine knot alpha-amylase inhibitors are high
11                    The best oxime-conjugated knottin dimer achieved an unprecedented 150-fold increas
12 based dimerization strategy was critical, as knottin dimers created through genetic fusion to a bival
13 cross-linkers of different lengths to create knottin dimers with varying molecular topologies.
14 o contains a region homologous to the TAXI-1 knottin domain; however, a deletion in this domain restr
15  complexity from simple to highly elaborated knottin domains, as well as double-knot toxins, that lik
16 d by dedicated genes or as a domain within a knottin-encoding PA1-albumin-like gene.
17 t the so-called "inhibitor cystine knot" or "knottin" fold stabilized by three disulfide bonds.
18  share the CCK motif with trypsin-inhibitory knottins from a plant in the Cucurbitaceae family.
19 us to natural cysteine-rich peptides such as knottins in that it is small and stable but can accommod
20                            The binding of MB-Knottin(Integrin) and MB-Knottin(Scrambled) to alpha(v)b
21  groups of tumor-bearing mice imaged with MB-Knottin(Integrin) and with MB(cRGD).
22                                           MB-Knottin(Integrin) attached significantly more to alpha(v
23 maging signal after the administration of MB-Knottin(Integrin) decreased significantly (by 64%).
24 cantly higher after the administration of MB-Knottin(Integrin) than after the administration of MB(al
25  blocking of integrins, the attachment of MB-Knottin(Integrin) to alpha(v)beta(3) integrin-positive c
26 ging contrast agent was created by attaching Knottin(Integrin) to the shell of perfluorocarbon-filled
27 aging signals after the administration of MB-Knottin(Integrin) were not significantly different in th
28 (3) integrins with a low nanomolar affinity (Knottin(Integrin)).
29 l of perfluorocarbon-filled microbubbles (MB-Knottin(Integrin)).
30 egrin-positive cells (0.15 +/- 0.12) than MB-Knottin(Integrin).
31  newly detected homologs, particularly among knottin-like domains.
32 ize dimers of integrin-binding cystine knot (knottin) miniproteins with low-picomolar binding affinit
33 s introduced at different locations within a knottin monomer and reacted with dialdehyde-containing c
34 crease in apparent binding affinity over the knottin monomer.
35 -fold) in tumor cell binding relative to the knottin monomer.
36 t forms the inhibitory cystine knot (ICK) or knottin motif.
37 e/gram (%ID/g), compared with a low-affinity knottin peptide (IC(50), approximately 0.4 mumol/L; 1.48
38        The imaging results obtained with the knottin peptide are compared with standard 18F-fluorodeo
39       Excelsatoxin A (ExTxA), a pain-causing knottin peptide from the Australian stinging tree Dendro
40 decane-N,N',N'',N'''-tetraacetic acid (DOTA)-knottin peptide that targets integrins upregulated durin
41                                            A knottin peptide with a scrambled sequence was used to cr
42                        This integrin-binding knottin peptide, denoted EETI 2.5F, was evaluated as a m
43                                  We report a knottin peptide-drug conjugate (KDC) and demonstrate tha
44 with a fluorescent, engineered cystine knot (knottin) peptide that binds with high affinity to alphav
45 a small, disulfide-constrained cystine knot (knottin) peptide that bound to alpha(v)beta(3) integrins
46 pared with other engineered integrin-binding knottin peptides and with c(RGDfK), a well-studied integ
47                             Integrin-binding knottin peptides can be conjugated to the surface of mic
48          Furthermore, (64)Cu-DOTA-conjugated knottin peptides generated lower levels of nonspecific l
49            Thus, engineered integrin-binding knottin peptides show great potential as clinical diagno
50 usly, we used directed evolution to engineer knottin peptides that bind with high affinity ( approxim
51 is work expands the therapeutic relevance of knottin peptides to include targeted drug delivery, and
52 roximately 20 nmol/L) (64)Cu-DOTA-conjugated knottin peptides was 4.47% +/- 1.21% and 4.56% +/- 0.64%
53                       (64)Cu-DOTA-conjugated knottin peptides were stable in mouse serum, and in vivo
54 y plays a strong role in the tumor uptake of knottin peptides.
55 ted for predicting recombinant expression of knottin peptides.
56        Additionally, we demonstrate that the knottin PET tracers can also detect fibrotic lung diseas
57 3.0 A) and the antifungal protein Rs-Afp1 [a knottin protein from radish (Raphanus sativus), rmsd of
58 bility to inhibit binding of a biotinylated "knottin"-RGD peptide to surface-immobilized integrins an
59 ers, such as integrin-immobilization levels, knottin-RGD concentration, buffer compositions, type of
60 near GRGDS, (ii) cyclo[RGDfK], and (iii) the knottin-RGD itself for binding to three different integr
61               We introduced the biotinylated knottin-RGD peptide instead of biotinylated cyclo[RGDfK]
62                                   Binding of knottin-RGD peptide was strongest for alphavbeta3 but al
63       The solvent-accessible surfaces of the knottin scaffold segments have distinctive shape and cha
64        Swapping analyses identified distinct knottin scaffold segments necessary for different CXC-ch
65 cysteine residues forming a disulfide-bonded knottin scaffold that creates a contiguous solvent-acces
66                                              Knottin scaffolds therefore appear to be a promising arc
67                                   Control MB-Knottin(Scrambled) adhered less to alpha(v)beta(3) integ
68   The binding of MB-Knottin(Integrin) and MB-Knottin(Scrambled) to alpha(v)beta(3) integrin-positive
69  was used to create control microbubbles (MB-Knottin(Scrambled)).
70 inistration of MB(alphavbeta3) or control MB-Knottin(Scrambled).
71 upting cell membranes; and 3) disulfide-rich knottins similar to those that dominate spider venoms.
72 h peptides, and we show that 15 of these are knottins that contribute >90% of the venom proteome.
73 nd validation of a new cystine knot peptide (knottin) that selectively recognizes human integrin alph
74 -rich peptide from Hibiscus sabdariffa, as a knottin-type neutrophil elastase inhibitor.
75                 Here, we attempted to create knottins with novel binding activities based on the cell