ライフサイエンスコーパス: known

1 lar basis for this increased activity is not known.

2 signaling in the CL of water buffalo is not known.

3 experimentally measured lambdamax values are known.

4 nal implications of such alterations are not known.

5 fill these physiological requirements is not known.

6 mations that this circuit implements are not known.

7 e associated with breast cancer are not well known.

8 functional role of the myocytes is less well known.

9 ng duct from the inner stripe (OMCDi) is not known.

10 FC for memory transfer/consolidation, is not known.

11 effects of vagus nerve stimulation are well known.

12 n variant status and 129 with variant status known (59 carriers/70 non-carriers).

13 formed in outpatient settings, yet little is known about facility-level variation in short-term safet

14 However, little is known about homeostatic mechanisms in the intact central

15 However, little is known about how excitatory-inhibitory balance is defined

16 However, little is known about how HIV-1 latency affects their function.

17 However, little was known about how leptin acts in the NTS neurons to inhibi

18 for climate change mitigation, yet little is known about how reactive Fe and Al minerals affect C cyc

19 Little is known about how spectral cues contribute to the neural e

20 e to the extracellular matrix, but little is known about integrin's regulators in the glia.

21 wasting is also common in COPD, but less is known about its contribution to LV size.

22 Little is known about its evolutionary history.

23 nt to many conventional therapies, little is known about its influence on VDA activity.

24 een studied more extensively, very little is known about mechanisms of regulation or signaling of the

25 However, much less is known about the ability of postingestive signals to modu

26 Little is known about the age-related physiological and morphologi

27 However, little is known about the cellular dynamics that mediate postnatal

28 Little is known about the changes in symptom classification over t

29 However, little is known about the circuits that integrate these time cues

30 ing peptides (CPPs); however, very little is known about the design of CPPs for efficient transcellul

31 However, little is known about the detailed electrical activity inside the

32 Little is known about the development of aggression regulation fol

33 Little is known about the effects of eradication of HCV on bone mi

34 However, little is known about the exact mode of action of the serotonin me

35 However, whilst much is known about the existence of T-R conflicts, our understa

36 directly or indirectly, virtually nothing is known about the extent to which CodY exerts its effect t

37 Importantly, little is known about the factors that cause protein misfolding an

38 nt of the animal's microbiome, but little is known about the host's actual role and if it benefits fr

39 ared with conventional T cells, much less is known about the immune functions of unconventional T cel

40 h microbes influence plant growth, little is known about the impact of microbial diversity on plant f

41 However, extremely little is known about the importance of social relationships betwe

42 In comparison, much less is known about the importance of these two arms of the defe

43 to the viral infection cycle, very little is known about the location and folding stability of functi

44 dration, and pathogen invasion-but little is known about the mechanisms by which this occurs.

45 age and Ca(2+) activations interact, less is known about the mechanisms involved.

46 d into multiprotein complexes, but little is known about the mechanisms required for assembly membran

47 PCs during kidney development, but little is known about the molecule(s) regulating FGF signaling dur

48 Escherichia coli or Salmonella, yet, less is known about the packaging motor of Pseudomonas-phages th

49 profound changes in behavior, but little is known about the precise molecular mechanisms that underl

50 However, little is known about the processes and factors mediating LILRB1 t

51 tate are reasonably well understood, less is known about the requirements for its establishment.

52 However, little is known about the role of calcineurin in promyelinating SC

53 Yet little is known about the spatial content of saccade transients.

54 antigen (TAg), and malignancy, yet little is known about the specific integration mechanisms and the

55 However, little is known about the specificity of extracellular peptidases

56 e that in about 1960 practically nothing was known about the thymus and some of its products, T cells

57 Much less is known about the trends affecting most invertebrates and

58 As yet, little is known about the underlying mechanism.

59 to extracellular stimuli, although little is known about the underlying mechanisms that govern such h

60 However, little is known about their evolutionary adaptations to these high

61 expressed in the brain, little is currently known about their function in the nervous system.

62 their epidemiological importance, little is known about their infection phenotypes.

63 is maintained in the adult brain, little is known about their role in mature neurons.

64 nterfacial proteins, comparatively little is known about their structure.

65 However, less was known about whether mindfulness meditation might alter p

66 ox proportional hazards models to adjust for known adverse prognostic factors.

67 y in Korea appears to be more similar to the known African viruses than to any other Asian viruses.

68 preading depolarizations (SDs) and seizures, known agents of clinical worsening after TBI.

69 In addition, by spiking in known amounts of HCPs to purified antibody drug substanc

70 ion in which all molecular polymorphisms are known and for which molecular endophenotypes and complex

71 pennellii revealed that expression levels of known and novel candidate genes (putatively encoding bet

72 al traits, may be more common than currently known, and may play a fundamental role in age-dependent

73 s involved in synaptic transmission are well known, and their features, as their abundance or spatial

74 vice integration was used to attach the well-known anthracene-boronic acid (An-BA) probe to a biomime

75 expected to cause hearing problems in noise, known as "hidden hearing loss," but existing studies are

76 browning, and sterility, a stress condition known as "tassel blasting." We identified a mutant, necr

77 luoro-analog of UCB-J ((18)F-SynVesT-1, also known as (18)F-SDM-8), which displayed favorable propert

78 le (MT) plus-end tracking proteins (commonly known as +TIPs) to induce the formation of stable microt

79 genases consume the metabolite alphaKG (also known as 2-oxoglutarate) as an obligate cosubstrate and

80 gen through a Darwinian evolutionary process known as affinity maturation.

81 Patients with the neurological syndrome known as body integrity dysphoria express a desire to am

82 ss uncontrolled off-the-person type database known as CYBHi.

83 thelial cells spontaneously form acini (also known as cysts or spheroids) with a single, fluid-filled

84 ed the role of protein diaphanous homolog 1 (known as Diaph1 or mDia1) for the myofibroblastic activa

85 sis was identified in a rare form of leprosy known as diffuse lepromatous leprosy (DLL).

86 s, termed colonic diverticular disease (also known as diverticular disease).

87 al egg surface during a gastrulation process known as epiboly.

88 An ARF GEF known as General receptor for 3-phosphoinositides 1 (Grp

89 In horses, the autosomal recessive condition known as Glycogen Branching Enzyme Deficiency (GBED) is

90 butions of greenhouse gas (GHG) fluxes, also known as hot spots and hot moments.

91 n which the cause cannot be identified (also known as idiopathic intracranial hypertension), and seco

92 LSD1 (lysine specific demethylase; also known as KDM1A), the first histone demethylase discovere

93 on loss of the histone demethylase UTX (also known as KDM6A) and activation of the RTK FGFR3, two eve

94 Acyl protein thioesterase 2 (APT2, also known as LYPLA2) depalmitoylates phosphorylated STAT3 (p

95 ervous system hosts parenchymal macrophages, known as microglia, and non-parenchymal macrophages, col

96 d in substoichiometric quantities, a process known as organocatalysis.

97 The latter compounds, better known as plasmalogens, harbor a vinyl ether double bond

98 HPV) infection, the cellular protein complex known as retromer binds to the L2 capsid protein and sor

99 Enzymes specialised for this task are known as ring nucleases, but are limited in their distri

100 Ulva lactuca, commonly known as sea lettuce, is a fast growing seaweed in the N

101 d has been reported to form amyloid fibrils, known as semen-derived enhancer of viral infection (SEVI

102 bubbles oscillating in a stable motion, also known as stable cavitation.

103 a specific type of structural equation model known as the Actor-Partner Interdependence Model.

104 egans produces a broad family of pheromones, known as the ascarosides, that are modified with a varie

105 is cleaved at its base by an enzyme complex known as the Microprocessor (Drosha/DGCR8).

106 channel in the inner mitochondrial membrane known as the PTP (permeability transition pore) and that

107 We confirmed and extended known associations and reported several novel causal ass

108 al tissues, as well as genes associated with known autosomal dominant OFC syndromes.

109 implementation based on the consideration of known barriers and facilitators.

110 sis of DGAT2's acyl-donor specificity is not known because of the inherent challenges of predicting s

111 of ARL13B (V358A) and showed it retains all known biochemical function.

112 The learned factors reflect tissues with known biological similarity and identify transcription f

113 dly applicable to various diseases with well-known biomarkers in diagnostics and monitoring, especial

114 CNAs affect genomic regions containing well-known breast-cancer genes.

115 The pathogenesis of ASD is not known, but it involves activation of microglia.

116 ed in malignant brain tumors 1 (DMBT1) (also known by the aliases GP340 and SALSA), a large glycoprot

117 s and to obtain a deeper characterization of known cancer genes.

118 We find hundreds of variants within known cancer-related genes detectable only through long-

119 and ynfE), as well as recovering previously known cases (in sigK, spsM, comK, mlrA and hlb genes).

120 /K(+)-conducting channel and, in contrast to known cation channelrhodopsins, it is impermeable to Ca(

121 precise mapping of core fragility regions in known CFSs and identification of novel fragile sites.

122 dral cages, some of which are reminiscent of known clathrate types while others are unique to this st

123 Cox proportional hazards model adjusted for known clinical predictors showed that serum-PC EPA at th

124 While there are known clinical risk factors for severe RSV infection, th

125 Since the advent of additive manufacturing, known commonly as 3D printing, this technology has revol

126 This is the first known community transmission case of the novel coronavir

127 ractionation mass spectrometry, we recovered known complexes, confirmed complexes predicted to occur

128 In addition to known components of the interferon signaling pathway, we

129 We suggest applying a well-known concept in computer science-committee machines-in

130 Despite its known connection with heparanase, a recently identified

131 on the paternal chromosome make the largest known contribution to autism risk, and correlate with pa

132 chromatin remodeling BAF complex, which has known contributions to developmental processes.

133 t stroke or transient ischemic attack and no known coronary heart disease.

134 es that efficiently and selectively captured known CS-E-binding proteins in vitro and in cells.

135 Rhombencephalosynapsis has no previously known definitive genetic or environmental causes.

136 These QC measures reflect known differences in sequencing protocol and provide a g

137 isproportionation with formation of the well-known dinuclear complex [(tBuO)(3)Mo=Mo(OtBu)(3)] and a

138 anked candidate genes by their similarity to known disease genes in protein-protein interaction netwo

139 tal disease, and Porphyromonas gingivalis, a known driver of periodontitis, has been proposed as the

140 However, its actual range is not well known due to the lack of a formal description until rece

141 Known duration of HIV diagnosis does not seem to be a cr

142 a-lysophosphatidylinositol (LPI) is its only known endogenous ligand.

143 Our approach leverages the known equivalence between the driving forces for single-

144 olecular organic semiconductors (OSCs), with known excitonic up- and down-conversion properties, are

145 th no evidence of TB infection by TST and no known exposure to TB were used as controls to establish

146 , and so, it may not detect relevant, lesser known, exposures.

147 Although this high risk of CVD has been known for decades, patients with RA receive poorer prima

148 Collagen VI (COL6) is known for its role in a spectrum of congenital muscular

149 tegy for free sulfhydryl groups in tissue is known for MALDI MSI.

150 lastomas are aggressive primary brain tumors known for their inter- and intratumor heterogeneity.

151 Best known for their role in fission at the late stages of CM

152 Yet the most ancient stem-salamanders, known from mid-Jurassic rocks, shed little light on the

153 strategy against predation, previously only known from trilobites preserved in open-marine deposits.

154 tural stability (C253) and (4) those with no known function (C28 and C75).

155 PID found that disease-causing mutations in known genes that are implicated in monogenic PID occurre

156 ation in the C9orf72 gene is the most common known genetic cause for amyotrophic lateral sclerosis (A

157 erved between neuroanatomical phenotypes and known genetic risk factors for schizophrenia.

158 constructed weighted polygenic scores using known genome-wide significant associations for T2D, fast

159 ives of a patient with ovarian cancer with a known germline pathogenic cancer susceptibility gene var

160 illate placoderms are the most plesiomorphic known gnathostomes, and the shared cranial architecture

161 quality of a set of markers when there is no known ground truth.

162 We used the well known hierarchical structure of the visual motion pathwa

163 Our findings show that the known high-risk CNVs are not only associated with schizo

164 opulation-based data from ~22,000 persons of known HIV status to characterize migratory patterns and

165 It is not known how activating ESR1 mutations may alter the predic

166 It is not known if use of colloid solutions containing hydroxyethy

167 All of the 41 patients with known implant information had implants with textured sur

168 Leber's congenital amaurosis (LCA) is a known inherited retinal disease (IRD) associated with se

169 dimentation profiles to all RNAs, confirming known interactions and predicting new associations.

170 We describe the well-known interactions with RNA polymerase as well as a broa

171 control group comprised individuals without known intestinal disease who were referred for colorecta

172 rus disease 2019 patients are not completely known, it is clear that hyperinflammation and coagulopat

173 ars, several hierarchical extensions of well-known learning algorithms have been proposed.

174 nalyses of 47 teeth from 15 individuals with known life history events and were able to detect reprod

175 ogether with many "orphan" receptors without known ligands.

176 Background Despite known limitations, the decision to operate on abdominal

177 Here, we highlight known loss-of-function mechanisms underlying ALS, potent

178 A collection of known luminescent COF systems will be featured.

179 sal interactions and becomes associated with known lysosomal trafficking and proteolytic proteins lik

180 Our eventual focus is on predictors with known mechanisms of reactions involved in drug resistanc

181 gic targets for miR-17 and miR-548b that are known mediators of lung injury.

182 e optimal growth temperature (OGT) for every known microbial species, organisms adapted to different

183 It is a known mitotic regulator, and it is well-described that K

184 at the airborne fungal ecology of homes with known mold growth ("moldy") differs from the normal airb

185 a framework that will distill the currently known multiple models of collaboration.

186 We also provide an update on known mutations and sulfonylurea therapy in neonatal dia

187 Genetic analysis of known nanophthalmos genes MFRP and TMEM98 were negative,

188 as likely catalytically inactive, similar to known negative regulators of RNA editing.

189 Finally, we summarize what is known of the mechanisms underlying opioid exposure and s

190 Focusing on C-MYC, a well-known oncoprotein overexpressed in most human cancers, w

191 ecommended for asymptomatic individuals with known or suspected contact with a COVID-19 case.

192 rein, we describe bacterial metabolites with known or suspected neuromodulatory activity, define mech

193 y effect of RUNX3 in beta-catenin is already known, our results suggest the possibility of a feedback

194 or a high suspicion of malignancy because of known pre-existing systemic malignancy or the presence o

195 ter intracerebral hemorrhage, independent of known predictors of outcome.

196 pecifically, resulting in the formation of a known product, confirmed to be the Vi monomer both de-O-

197 developed a risk stratification system from known prognostic factors and assessed it in the context

198 cortical inhibition can account well for the known properties of direction selectivity in carnivores

199 Gene-based rare variant tests implicated a known prostate cancer gene (HOXB13), as well as a novel

200 reens successfully identified genes encoding known receptors for previously characterized viruses of

201 igh or low IQ and after removing de novo and known recurrent neuropsychiatric CNVs.

202 re established targets of cisplatin, less is known regarding the afferent synapse, which is an essent

203 ent in the virgin mammary gland, but less is known regarding the effects of macrophages on the adipos

204 However, little information is known regarding the molecular mechanisms associated with

205 c1 promotes the expression of twist1b-a well-known regulator of epithelial-to-mesenchymal transition.

206 While PKA is a well-known regulator of physiological and oncogenic events, t

207 discovering ab initio the binding motifs for known regulators and some unknown ones.

208 ression, likely due to activation of E2F1, a known repressor of miR-223 transcription.

209 Known resistance mutations to targeted therapies were nu

210 Finally, we provide evidence that the well-known right lateralization of face processing arises fro

211 Further, known risk factors accounted for substantially less of t

212 e sample of MSM despite a high prevalence of known risk factors, reflecting either the need for a thr

213 ubarb for the first time in addition to well-known secondary metabolites including emodin, aloe-emodi

214 The most complete known skull of this species is DNH 7 from Drimolen Main

215 d ratios of the MS ion responses against the known spiked-in ratios (CVs < 8% for calibration standar

216 In silico tests using known stability data, and in vitro tests using three mem

217 undamped stiffness 100 times larger than the known static stiffness.

218 By comparison with known structures, we deconvolute structural changes gove

219 To date, however, no known study has examined whether social environmental fa

220 Beyond these known subsets, we identify CD4(-)CD8(-)TCRalphabeta(+),

221 turally heterogeneous peri-infarct zone is a known substrate, but the functional role of the myocytes

222 Primo to examine the molecular mechanisms of known susceptibility loci and to detect and interpret pl

223 87.9%) children, and 3638 were tested with a known test outcome, giving an overall testing uptake amo

224 It is well known that activation of the kappa opioid receptor syste

225 It is well known that alcohol consumption is associated with type 2

226 While it is known that BK channels are activated by voltage and Ca(2

227 It is widely known that cigarette smoke damages host defenses and inc

228 It is known that growth factors such as insulin, IGF-1 and HGF

229 Although it is known that the expression of BMI1 is increased in many c

230 It is well known that the integration among different data-sources

231 the structure of the desmosomal cadherins is known, the desmosome architecture-which is essential for

232 owing number of environmental pollutants are known to adversely affect the thyroid hormone system, an

233 on mechanosensitive channel nanopockets are known to affect mechanical gating and may be linked to l

234 The local lipid environment is known to affect the structure, stability and intercellul

235 d interactions with the human host have been known to attribute detrimental and beneficial effects on

236 with the risk of CAD within genomic regions known to be associated with CAD.

237 Holdase chaperones are known to be central to suppressing aggregation, but how

238 er noble-metal-based delafossites, which are known to be challenging due to the difficulty in initial

239 s contain conserved sequence motifs that are known to be important in helix packing.

240 Here, we describe diseases known to be influenced by iCP activity and the current s

241 ene in the antimicrobial peptide pathway and known to be involved in antimicrobial and anti-inflammat

242 2)- and O(4)-alkylated thymidine lesions are known to be poorly repaired and persist in mammalian tis

243 of the genes with increased expression were known to be regulated by peroxisome proliferator-activat

244 mPDAT, GmPLDalpha1 and GmDAGAT1) are already known to be related to oil synthesis.

245 were identified near RA target genes already known to be required for body axis and limb formation, t

246 tion, a minor fatty acid degradation pathway known to be stimulated by C(12) accumulation, was increa

247 hesis, is the most abundant regulatory motif known to biology.

248 (PAHs) are common atmospheric pollutants and known to cause adverse health effects.

249 nd more than 40 tandem repeat expansions are known to cause neurological disease.

250 Although LF is known to cleave mitogen-activated protein kinase kinases

251 role of Asc in NPQ in green algae, which are known to contain low amounts of Asc, we searched for an

252 microalgal species, diurnal cycles are well known to control the metabolism, growth, and cell divisi

253 present the most potent V-ATPase inhibitors known to date.

254 minimising accumulation of lipid metabolites known to disrupt skeletal muscle insulin signalling in s

255 The intracellular protein SOCS1 is known to downregulate cytokine signaling by inhibiting t

256 galaxy(9-12), and just one of these four is known to emit repeating FRBs(9).

257 Alkoxy radicals have long been known to enable remote C-H functionalization via 1,5-hyd

258 cur from the supersaturated calcifying fluid known to exist in corals, or from a dense liquid precurs

259 variations of total arsenic and all species known to exist in PM.

260 Both full-length TDP-43 and its CTD are also known to form stress granules by coacervating with RNA i

261 rylating these sites, including 7 previously known to function in the clock.

262 whether spatial maps in sensorimotor regions known to guide overt and covert spatial selection are in

263 Nanosized materials are known to have the ability to withstand ultralarge elasti

264 drug laninamivir in AIVs with substitutions known to impart resistance to other NAIs.

265 Compounds known to induce MT release like progesterone, ZnSO(4), q

266 utyl-phthalate (DBP, a plasticising chemical known to induce testicular dysgenesis in vivo in rats).

267 lpha band activity, a prominent brain rhythm known to influence perceptual reports in general.

268 operties of extracellular vesicles (EVs) are known to influence their biological function, in terms o

269 In the Friend virus (FV) model, Tregs are known to inhibit effector CD8+ T-cell responses and cont

270 Viral IRFs 1, 3, and 4 are known to interact with ubiquitin-specific protease 7 (US

271 of beta oscillations in the motor cortex are known to lead to muscle responses of greater amplitude.

272 Many non-ant parasites of ant colonies are known to mimic the morphology of their host species, oft

273 (dengue virus and Zika virus) particles are known to near-atomic resolution and show detailed struct

274 n that rate-limiting steps of metastasis are known to occur while tumor cells enter, travel through,

275 ydroxylase (TH), a compartment where PPGL is known to originate.

276 creted protein of region of difference 1, is known to play a crucial role in virulence and pathogenes

277 nmental factors, and in particular diet, are known to play a key role in the development of Coronary

278 ession of opsins and phototransduction genes known to play a role in light detection in most animals.

279 ProQ is an RNA-binding protein that has been known to play a role in osmoregulation in proteobacteria

280 The thalamus is known to process information from various brain regions

281 and insulin-like growth factor-1 (IGF-1) are known to promote fibrosis; however, myofibroblast specif

282 Host relatedness and traits known to promote vector exposure neither predicted infec

283 r eubiotic conditions commensal microbes are known to provide a competitive barrier against invading

284 ties of multiple signaling pathways that are known to regulate HF stem cells.

285 Although many genes are known to regulate those processes, the molecular mechani

286 These myeloid cells are known to secrete several proangiogenic factors in tumors

287 Shedding of gp120, known to severely complicate structural studies, can be

288 asmic vesicles in vascular endothelial cells known to stain for NADPH diaphorase were rich in S-nitro

289 t or positions of HCs since daughter HCs are known to switch positions with each other.

290 expression of PAX9, MSX1, AXIN2, and RUNX2 (known tooth development genes) was perturbed in mutant c

291 ombinatorial binding patterns that show well-known TRMs and related TF co-binding events.

292 Systemic application of NS8593, a known TRPM7 inhibitor, prevents kidney atrophy in UUO ki

293 vity of 34 inteins (both uncharacterized and known) using a rapid split fluorescent reporter characte

294 These frequencies correspond to known vibrational modes of chlorophyll, suggesting that

295 ve to the structural landscape of other well-known viral RNAs.

296 the complete reference protein sequences of known viruses with human tropism.

297 ide a causal, mechanistic account for a long-known visual illusion.

298 However, it is not known when succinoglycan intervenes in the symbiotic pro

299 It is not known whether such neuroadaptations are affected by numb

300 enes in the symbiotic process, and it is not known whether the plant lysin-motif receptor-like kinase