ライフサイエンスコーパス: label

1 after experimental intervention (e.g., pulse labeling).

2 s, i.e. immobilization matrix, catalyst, and label.

3 is better suited to learn from heterogeneous labels.

4 ite-directed modifications or bio-orthogonal labels.

5 can introduce bias into the final clustering labels.

6 at carry two spectrally distinct fluorescent labels.

7 porated BrdU, whereas 88% of neck cells were labeled.

8 is, posttranslational modifications, and DNA labeling.

9 ctron microscopies as well as stable isotope labeling.

10 laborious steps of protein purification and labeling.

11 d substrate in the first step for subsequent labeling.

12 ponential protein barcoding system which can label 128 clones using seven antibodies.

13 sing (14)C-radiolabeled ((14)C-AA) and (13)C-labeled ((13)C(3)-AA) materials.

14 In AUGUSTUS (Open-Label, 2x2 Factorial, Randomized, Controlled Clinical Tr

15 MrgprC11(CreERT2) transgenic mouse line, we labeled a small subset of itch-sensing neurons that expr

16 and in vivo, we find that RFX6 specifically labels a subset of PDX1-expressing pancreatic endoderm.

17 e labeling cells and 1-2 weeks to test their labeling ability.

18 el skeletal muscle actin in 1981, the pyrene-labeled actin has become the most widely employed tool t

19 agents surrounded by a threshold of equally labeled agents increases.

20 o the multiobjective model, a multi-criteria labeling algorithm is then proposed.

21 hese cells to form labeled plasmalogens from labeled alkylglycerols.

22 pulse labeling approach using stable isotope-labeled amino acids in cells (pSILAC), phosphoproteomics

23 milarities and differences in the pattern of labeling among the human, rat, and mouse in these brain

24 The fluorescently labeled analogs of GalNAc-conjugated PNAs were internali

25 been impeded by the inability to selectively label and manipulate them.

26 Here, we describe how to use this method to label and/or genetically manipulate cells in the neonata

27 Projection-specific labeling and calcium imaging showed that the great major

28 Using genetic labeling and calcium imaging, we show that npvf-expressi

29 f cardiomyocytes by combining stable isotope labeling and click chemistry with subsequent mass spectr

30 ble reaction for site-selective biomolecular labeling and imaging.

31 18)F-rhPSMA-7 offers the advantages of (18)F labeling and low urinary excretion compared with (68)Ga-

32 ant analysis, metabolic engineering, isotope labeling and metabolic profiling to capture PFCs and dem

33 Using metabolic labeling and pulse-chase analysis of HIV-1 Gag proteins,

34 yrosyl-tRNA mimic that blocks translation by labeling and releasing elongating polypeptide chains fro

35 Using domain-specific BioID proximity labeling and super-resolution imaging, we identify CEP11

36 al implementation of the Chilean Law of Food Labelling and Advertising, there was a significant decre

37 s applications such as site-specific protein labelling and in vivo cancer imaging.

38 the number and depth of hierarchical lineage labels and by flagging and delabelling virus lineages th

39 Biomolecules were fluorescently labeled, and fluorescence microscopy was employed to ass

40 x3.1 reduces proliferation, enhances DNA end-labeling, and protects from DNA damage, ultimately block

41 rized by tandem mass spectrometry, deuterium labeling, and UV/Vis action spectroscopy.

42 ic abstracts without a large training set of labeled annotations.

43 by approximately 40 MBq of one of the (89)Zr-labeled antibodies injected intravenously in a periphera

44 sible antigen-mAb complex and the free (15)N-labeled antigen whose (1)H-(15)N correlations are detect

45 the sensory domain, we used a genetic sparse labeling approach to track SGNs and found no differences

46 ible mass spectrometry-based method, a pulse labeling approach using stable isotope-labeled amino aci

47 All of these covalent labeling approaches combine to constitute a problem-solv

48 ose from unsupervised clustering in which no labels are assigned to the data.

49 ionally, thoracic aortic aneurysms have been labeled as a degenerative disease, characterized by alte

50 ns, osteomyelitis, and septic arthritis were labeled as IDRIs if discharge codes included opioid and/

51 ing a small-molecule additive during the TMT labeling as a decoy reagent to deplete the excess amount

52 Arterial spin labeling (ASL) is a neuroimaging technique used to measu

53 Arterial spin labeling (ASL), as a non-invasive and non-contrast enhan

54 mediated deoxyuridine triphosphate nick end labeling assay.

55 Metabolic labeling assays, FADS3 overexpression and knockdown appr

56 mors on the basis of training data that were labeled automatically from simulated clinical image inte

57 Imaging the depletion of fluorescently labeled bacteria provides information on both the distri

58 Here, we extend a modular method for labeling base modifications in DNA to recognize all four

59 antiCD81 modified magnetic particles and the labeling based on CD24 and CD340 as cancer-related bioma

60 protein that was validated by photoaffinity labelling-based target mapping.

61 Adoptive transfer of labeled bone marrow-derived cells validated the results

62 ly, we constructed a library of isotopically labeled bottlebrush molecules and measured the bottlebru

63 in CGRP(+), TH(+), and Iba1(+) (macrophage) labeling, but no increase in ATF3(+) cells.

64 quencing in which fixed cells are chemically labeled by attaching identifying DNA oligonucleotides to

65 tients, yielding over 3000 swallows manually labeled by experienced speech language pathologists.

66 nd microRNA-128 (miR-128) binding sites, and labeled CaMKIIalpha(+) cells with naturally low expressi

67 his protocol takes 2-3 weeks to generate the labeling cells and 1-2 weeks to test their labeling abil

68 The metformin label change to an eGFR-based contraindication may have

69 racteristics of postapproval, safety-related label changes.

70 but also quantitative information for every labeling channel and avoid the issue of ratio distortion

71 that uses metal ion-loaded and fluorescently labeled chelator heads to detect His-tagged proteins in

72 We compared the number of WMNsST with labeled claustral and cortical neurons and also estimate

73 In an open label clinical trials, participants with ASD were admini

74 r different models: (a) 375 neuroradiologist-labeled clinical DW positive stroke cases (CDB); (b) 200

75 culties in supplying a suitably isotopically-labelled cofactor ([4-(2)H]-NADH).

76 d synthesis of 20 tritiated and 10 carbon-11-labelled complex pharmaceuticals and PET radioligands, i

77 50% decrease in wheat germ agglutinin (WGA)-labeled components of the GCX under DF conditions, vs UF

78 the design and synthesis of a small-molecule label comprising both fluorogenic and self-blinking feat

79 tes, as was visualized using a fluorescently labeled conjugated bile salt.

80 This open-label, consecutive-panel, phase 1b trial was done at Cha

81 ion, we conducted a 6-week, randomized, open-label crossover trial comparing amiloride/hydrochlorothi

82 ained on our proprietary, large and expertly labeled dataset consisting of 12-lead ECGs from 40,258 p

83 We asked curators to assign labels describing SV type (deletion or insertion), size

84 small proportion of women included, the open label design, and its short duration.

85 We developed a new tracer, an (18)F-labeled difluoro-analog of UCB-J ((18)F-SynVesT-1, also

86 Unlabeled and deuterium-labeled dimeric lignin model compounds with beta-O-4 lin

87 9 to compassionate use of remdesivir, or off-label drug use of hydroxychloroquine or other therapies.

88 i-BLESS labels DSBs with single-nucleotide resolution, allows de

89 mFRET) to measure the conformation of a FRET labelled E2~Ub conjugate, which distinguishes between cl

90 We performed pretraining using 494,364 labeled endoscopic images collected from all intestinal

91 reesei using the colocation of a fluorescent label (enhanced yellow fluorescence protein, EYFP) with

92 Site directed spin labeling EPR and DEER (double electron-electron resonanc

93 parcellated the entire brain directly in 3D, labeling every voxel with a brain structure spanning 43

94 We showed, for the first time, the videos of labeled EVs uptake by living lung cancer cells.

95 Image analysis of fluorescent labeled exosomes derived from three cell lines injected

96 Deuterium labeling experiments and a comprehensive computational s

97 tructural insights and guided stable-isotope labeling experiments, which led to the assignment of the

98 echanism was studied by performing deuterium-labelling experiments, which indicated that the gamma-C(

99 2 weeks (part A), followed by a 40-week open-label extension (part B), during which time all particip

100 were isolated, incubated with fluorescently labeled fatty acids or glucose analog, and analyzed by c

101 (MACA) induced self-quenching of acyl chain-labeled fluorescent PIP2 in liposomes, implying clusteri

102 learning tasks for the scRNA-seq data, where labels for cell types are costly and often impossible to

103 SCI-determined sub-compartments are used as labels for training.

104 It has also been used "off-label" for Enterococcal infections.

105 failing regimen for 8 days, followed by open-label fostemsavir plus optimized background therapy (ran

106 In the method, sequence labeling framework is extended by multiple specified fea

107 Label-free affinity electrochemical biosensors construct

108 The label-free and sensitive detection of synthesis products

109 We report a multiplex label-free antigen microarray on the Arrayed Imaging Ref

110 de that ICIRD spectroscopy is a noninvasive, label-free approach for assessing conformational changes

111 in expression in single MCF10A cells using a label-free approach.

112 In the present study, a sensitive label-free electrochemical aptasensor is introduced to m

113 his research demonstrates that the developed label-free electrochemical C-MEMS based PDGF-BB aptasens

114 y to use electrophysiological properties for label-free enrichment of human astrocyte-biased cells.

115 ce (SPR) technique is utilized for measuring label-free GPCR signal profiles.

116 Label-free high-throughput screening using mass spectrom

117 Here we demonstrate the use of label-free imaging flow cytometry and deep learning to c

118 sparent microfluidic channels and implements label-free imaging method for counting the separated cel

119 Here, we investigate label-free immunosensing, using a quartz crystal microba

120 hil phenotyping and infection diagnosis in a label-free manner.

121 We describe a label-free method based on spectral small-angle X-ray sc

122 anisms for its antimicrobial effect, using a label-free proteomic approach (LC/MS/MS) analysis to com

123 We developed FLEXIQuant-LF using label-free quantification of unmodified peptides and rob

124 ressing fluorescent proteins and demonstrate label-free readout on unlabeled Gram-negative and Gram-p

125 High- and ultrahigh-throughput label-free sample analysis is required by many applicati

126 ionalized field-effect transistor (FET) as a label-free sensor for AIV detection in chicken serum.

127 Label-free shotgun proteomics was applied to comprehensi

128 arge training datasets that hold the key for label-free single-cell analysis and, consequently, for d

129 s proof-of-principle study, we have utilized label-free spontaneous Raman spectroscopy to understand

130 on electrospray ionization (DESI) MS for the label-free study of enzymatic reactions directly from th

131 Real-time label-free techniques are used to profile G protein-coup

132 Currently available label-free technologies, e.g., thermal shift assays, cir

133 In this work, a facile, label-free, and ultrasensitive electrochemical DNA biose

134 ased identification of PG is noninvasive and label-free, the popularity of this approach has consider

135 Axotomized motoneurons were retrogradely-labeled from muscle before nerve injuries.

136 neuraminidase induced the degradation of WGA-labeled GCX under UF cell culture conditions or in Balb/

137 Feeding males with stable-isotope-labelled glucose revealed that the males produced these

138 of high quality, selectively stable isotope-labeled GPCR for studies by nuclear magnetic resonance.

139 The use of fluorescence labels has enabled new cell-sorting strategies and given

140 t the popularization of CBD-fortified or CBD-labeled health products and CBD-associated health claims

141 IVIS imaging of rhodamine labeled homopolymer depots showed that degradation and r

142 -kDa reactants and products is obfuscated by labels, however, as reaction kinetics are inevitably per

143 We report that the percentage of BONCAT-labeled (i.e. active) bacterial cells varies substantial

144 rase, "bump-and-hole" (BH)-GalNAc-T2, boosts labeling in a programmable fashion by increasing incorpo

145 Pulsed Stable Isotope Labeling in Cell culture (SILAC) approaches allow measur

146 taneously preserve potent and specific NCEH1 labeling in live cells and animals, while permitting fac

147 rms PLS-DA, which is made aware of the class labels in its input.

148 create an alternative method for estimating label incorporation.

149 ring in all H2B-FP transgenes independent of label induction, accumulated with age in HSCs with high

150 sting methods can be used to confirm whether labelled ingredients are present in the product.

151 assium on this response, we measured pendrin label intensity and subcellular distribution in wild-typ

152 The choice of appropriate stable isotope-labelled internal standard is crucial, given the diversi

153 We conducted an open-label, international, randomized, phase 3 trial involvin

154 Operationalizing penicillin allergy de-labeling into a new arm of antimicrobial stewardship pro

155 ydrogen bonding, whereas one drawback is the labeling is reversible.

156 ilisation of NADH-dependent enzymes for (2)H-labelling is not straightforward, owing to difficulties

157 monstrate accurate 21-plex quantification of labeled K562 human cell line protein digests via single-

158 that reported results of the phase III, open-label KATHERINE trial.

159 trate that the mammalian Expi293F amino acid labelling kit is suitable for preparation of multi-milli

160 e liquid chromatography of the fluorescently labeled library, allows the relative affinities of glyca

161 Here, we used a deuterium-labeled lipoprotein substrate with reconstituted Lit to

162 s and were thus subject to the law's warning label, marketing restriction, and school sales ban polic

163 participants in the MDMA group had one open-label MDMA session and placebo participants crossed over

164 ticipants crossed over to receive three open-label MDMA sessions.

165 The release rate of (177)Lu (or labeled metabolites) from tumor cells had the strongest

166 Sequence labeling method can be successfully used to extract docu

167 A very low subsequent transfer of this labeled methyl group to D3-PC indicated that liver PEMT

168 Genetically labeled mice established that L1 neurons are propriocept

169 We proposed a new normalization method, labeled MIXnorm, for FFPE RNA-seq data.

170 In this open-label, multicenter, noninferiority trial, we recruited p

171 SIRIUS was an open-label, multicentre, phase 2 study done in Canada, Spain,

172 This open-label, multicentre, single-arm, phase 2 trial was done a

173 itope residues, followed by infection of the labeled mutant virions in mammalian cells in the presenc

174 ly and temporarily accumulate the target and label nanoparticles on top of the test line (TL).

175 purportedly inhibit the release of puromycin-labeled nascent peptides from ribosomes.

176 TB injections restricted to TeO retrogradely labeled neurons confined to the visual AI.

177 been proposed to address the problem: sparse label-noise-robust logistic regression (Rlogreg), robust

178 The prospective, randomised, open-label, non-inferiority NOBLE trial was done at 36 hospit

179 This multi-center, prospective, open-label, observational, single-arm trial of 1200 patients

180 of the Ac-AG tag was demonstrated by triplex labeling of a yeast proteome spiked with bovine serum al

181 ed acyl imidazole chemistry enables covalent labeling of AMPA-type glutamate receptors in the same br

182 Here, we used direct labeling of B cells reactive with the N-acetyl-D-glucosa

183 odification of lysines or more site-specific labeling of cysteines, each with attendant challenges.

184 and the most reactive one was applied to the labeling of endogenous MAGL in live cells.

185 to its rapid internalization and subsequent labeling of internal membranes, we redesigned it by intr

186 labeling of PBPs with Bocillin FL, a fluorescent penicil

187 bases during DNA synthesis, which allows for labeling of replicating or repaired DNA.

188 finity DNA aptamer generation, site-specific labeling of RNAs, semi-synthetic organism creation, and

189 glycoprotein on the viral surface, covalent labeling of the Cys residues using a Cys-reactive label

190 We used genetic labeling of two of these proteins (PSD95 and SAP102), an

191 d Click chemistry with pulsed stable isotope labelling of amino acids in cell culture to quantify the

192 r rationally designed to enable preferential labelling of cancer cells, or specifically delivered to

193 Here, the effect of PKH labelling on the size of EVs was systematically evaluate

194 le particle formation was not due to the ICL labeling or complement attack and was observed after inj

195 We found that retrogradely labeled output neurons occupy discrete and likely strate

196 This was an open-label, parallel-group, randomized, controlled trial.

197 iple immune cell populations contain lineage-labeled particles, suggesting a phagocytic role in the c

198 gestion of target protein and employ isotope-labeled peptide internal standards to quantify chosen su

199 reporter ions following HCD fragmentation of labeled peptides acquired on Orbitrap platforms at a min

200 The isobarically labeled peptides are fragmented into sets of b- and y-io

201 d identification/quantification of partially labeled peptides.

202 double-blind treatment, but during the open-label period, more rapid progression was noted among pat

203 In this open-label phase 2 study (ClinicalTrials.gov identifier: NCT0

204 of MG infection in MSM enrolled in the open-label phase of the ANRS IPERGAY trial with on demand TDF

205 In this single-arm, open-label, phase 2 basket trial, we recruited patients from

206 CLL14 is a multicentre, randomised, open-label, phase 3 trial done at 196 sites in 21 countries.

207 Here, we report the first open-label, phase Ib clinical trial of a personalized neoanti

208 In an update of the randomized, open-label, phase III European Mantle Cell Lymphoma (MCL) Eld

209 cs, partially hydrolysed with hypoallergenic label [pHF-HA], extensively hydrolysed [eHF], soya) and

210 ulted in an inability of these cells to form labeled plasmalogens from labeled alkylglycerols.

211 e function with natural, unnatural and CF(2)-labelled post-translationally modified protein substrate

212 We did an open-label, pragmatic, adaptive, randomised controlled trial

213 Second, using the class label probabilities output by our DNN approach, we ident

214 o image the signal from distinct fluorophore-labeled probe types in a biplexed NAAT in a glass fiber

215 concatemer, an artificial and stable isotope-labelled protein composed of several concatenated signat

216 The use of terminal residues for labeling provides a universally applicable and easily sc

217 Conclusion: The (64)Cu-labeled PSMA ligands are promising agents to target PSMA

218 e demonstrate that autoSTOMP can efficiently label, purify, and identify proteins belonging to 1-2 mu

219 ucleotide analog incorporation that does not label quiescent cells, a property of most PCs.

220 We did an open-label, randomised clinical trial at 57 centres in Brazil

221 In this open-label, randomised controlled trial, adults (aged 16-55 y

222 In a multicentre, parallel-group, open-label, randomised study, children (aged 0-17 years) atte

223 DESIGN, SETTING, AND PARTICIPANTS: Open-label, randomized clinical trial conducted at 17 UK hosp

224 ted States into 2 identically designed, open-label, randomized clinical trials.

225 In an open-label, randomized controlled trial (RCT), consecutive pa

226 This phase 4, multicenter, open-label, randomized, control trial enrolled 360 children w

227 We designed an open-label, randomized, multicenter, two-arm phase II trial t

228 Similar patterns of retrograde labeling result from tracer injections into different NT

229 pite their functional heterogeneity, dormant label-retaining (LR) and non-LR hematopoietic stem and p

230 a GPCR) and Delta-like ligand 1 (DLL1), is a label-retaining cell that undergoes predominant asymmetr

231 Open-label retransplantation was offered after the trial.

232 Pulses of FDAA labeling revealed an arrangement of separate regularly s

233 se Rep-X sequentially releases fluorescently labeled riboswitch RNA from a heteroduplex in a 5'-to-3'

234 e been routinely assessed in oriented (15) N-labeled samples.

235 By exploiting a number of different labeling schemes, the two halves of the molecule can be

236 Site-directed spin labeling (SDSL) ESR is a valuable tool to probe protein

237 ctive hybridization with complementary, mass-labeled sequences.

238 sent study, by juxtacellularly recording and labeling single CA2/CA3 neurons in freely-moving mice, w

239 cal trials are lacking, we conducted an open-label, single-arm study to determine the impact of the b

240 In this multicentre, open-label, single-arm, multicohort, phase 2 study (FIGHT-202

241 In this multicentre, open-label, single-arm, phase 2 study (L-MIND), patients olde

242 In this open-label, single-arm, phase 3 trial, participants were recr

243 This open-label, single-arm, prospective cohort trial is the first

244 unctional groups into the reagent structure, labeling sites can be more easily identified by MS and M

245 N-(1-pyrene)iodoacetamide was first used to label skeletal muscle actin in 1981, the pyrene-labeled

246 hetic glutamate-based photoswitch via a self-labelling SNAP tag.

247 tor radionuclide therapy (PRRT) with (177)Lu-labeled somatostatin analogs in patients with somatostat

248 Labeled SP cells give rise to terminally differentiated

249 oach is by reactions with fast, irreversible labeling species that are highly reactive and footprint

250 of super-resolution imaging depends on high label specificity, making removal of excess dye essentia

251 small molecule fluorescent turn-on probe for labeling sphingosine in living cells.

252 homogeneously applied, stable, isotopically labeled standard for normalization and a matrix on top o

253 By incorporating stable isotope-labeled standards, these workflows allow the determinati

254 Deuterium labeling studies established homolytic H(2) (or D(2)) ac

255 netic isotope effect experiments, deuterated labeling studies, variable-temperature (1)H NMR spectros

256 omparative, active-control, randomized, open-label study in HIV-1-infected antiretroviral therapy-nai

257 This was a 24-week, single-arm, open-label study in treatment-experienced adults living with

258 In this open-label study, we assessed the histological efficacy of NG

259 conjugate clearly outperformed conventional labels such as enzymes or fluorescent dyes.

260 es between groups were indifferent, the mean labeled surface in the HA/TCP group was significantly gr

261 gh uptake and prolonged retention of an 89Zr-labeled surrogate of PEG~TLZ in the MX-1 BRCA1-deficient

262 ing of the Cys residues using a Cys-reactive label that masks epitope residues, followed by infection

263 ein, we use a peptide ligase, butelase 1, to label the human transferrin receptor 1 (TfR1) in establi

264 ular membranes without the need to purify or label the investigated membrane protein.

265 In addition to labeling the monoclonal antibody trastuzumab with excell

266 es cells expressing a fluorescent protein to label their surrounding cells, facilitating their specif

267 In an open-label titration phase, increasing doses of apomorphine s

268 ration types, microbial lineages and isotope labels to determine its consistency and therefore potent

269 horseradish peroxidase (poly-HRP, 400 HRPs) labels to provide large signal amplification and limits

270 be easily adapted to track the flux of other labeled tracers (such as (15)N-tracers) in any metabolit

271 Off-label treatment with tocilizumab restored the cytotoxic

272 location was fixed; this was denoted an open-label trial (OLT).

273 nical Trials Group A5312 is a Phase 2A, open-label trial in which individuals with smear-positive pul

274 In this randomised, open-label trial, DolPHIN-2, we recruited pregnant women in S

275 There was no masking in this open-label trial.

276 l deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay and immunohistochemistry for acti

277 This was an open-label, two-arm, non-inferiority, multi-center, randomize

278 lycosyltransferase C1GalT1 with isotopically labeled UDP-Gal((13)C(6)), to tag and convert Tn to Gal(

279 s concerning ranked genealogies without leaf labels unlock opportunities in the analysis of evolution

280 of these preliminary findings, temporary off-label use of Tpo-RAs for severe and/or refractory ITP du

281 l approach that applies several isotopically labeled versions, each at a different concentration, to

282 The superiority of the proposed approach for labeling vertebrae on three datasets was investigated: a

283 ree-dimensional approaches was achieved when labeling vertebrae on two-dimensional MIPs.

284 Newly synthesized proteins were then labeled via 'click chemistry'.

285 Overall, the FDA found that the model label was adequate for use in the development of a nalox

286 ured interferometrically, and no fluorophore labeling was required.

287 Using anterograde and retrograde labeling, we found that a sparse and relatively evenly d

288 lectron microscopy with glutamate immunogold labeling, we identified decreased intracellular glutamat

289 We addressed this by injecting labeled wild-type embryonic stem cells into blastocysts

290 ex cell rolling (FMCR) assay, each sample is labeled with a different signature of emission wavelengt

291 These neurons were most effectively labeled with an antiserum raised against tyrosine hydrox

292 ted regulatory networks with nodes and edges labeled with chromatin states in human cell lines.

293 ein was sandwiched with a secondary antibody labeled with horseradish peroxidase (HRP-DAb).

294 e lesions, using the GLP-1 agonist exendin-4 labeled with IRDye 800CW, was examined in vitro and in v

295 Neurons labeled with NeuroPAL do not exhibit fluorescence in the

296 However, it is labeled with the short half-life isotope (11)C.

297 Baskets were characterized further by triple labeling with CGRP, nitric oxide synthase (NOS) and calr

298 Here, we demonstrate that RNA labeling with the modified, nontoxic uridine analog 5-et

299 oligomer bearing a single m6A enzymatically labelled with a commercial conjugate of streptavidin-per

300 (EPR) spectroscopy of oligonucleotides spin-labelled with triazole-appended nitroxides at the 2' pos