ライフサイエンスコーパス: labeled compound

1 asurable metabolites derived from a specific labeled compound.

2 r) based on NMR coupling in the (15)N, (6)Li labeled compound.

3 straightforward access to complex deuterium-labeled compounds.

4 PAR probes including biotin and fluorophore-labeled compounds.

5 nly by convenient synthetic accessibility to labeled compounds.

6 logue groups that correspond to isotopically labeled compounds.

7 ning the pharmacological properties of (18)F-labeled compounds.

8 ing the mass isotopomer distribution for all labeled compounds.

9 olute flux was quantified with fluorescently labeled compounds.

10 ile preparation of isotopically enriched 15N-labeled compounds.

11 e catalytic site in the presence of the spin-labeled compounds.

12 advantageously explored noninvasively using labeled compounds.

13 inetic behavior of the corresponding (211)At-labeled compounds.

14 of FAPI-46 better than the (177)Lu- or (90)Y-labeled compounds.

15 3)CO(2) as a cost-effective source for (13)C-labeled compounds.

16 tion and nanoscale tracing of stable isotope-labeled compounds.

17 methods to synthesize deuterium- and tritium-labeled compounds.

18 ents and nonhuman primates (NHPs) with (11)C-labeled compounds.

19 evated liver uptake observed for both (64)Cu-labeled compounds.

20 tical techniques that enable tracking of the labeled compounds.

21 thyl terephthalate and zearalenone), a (13)C-labeled compound ((13)C(6)-ochratoxin A), and an octapep

22 The F-18-labeled compounds, 16 and 18a-c, were prepared via a two

23 Seven F-18 labeled compounds [(18)F]18a-e, [(18)F]18g, and [(18)F]2

24 Spin-labeled compounds, 5-doxylstearic acid (5-DSA), 7-doxyls

25 roven medical applications using its isotope-labeled compound (67)Ga-citrate.

26 diography of veins following uptake of (14)C-labeled compounds, analysis of leaf solute composition a

27 ical shift degeneracy that occurs in the non-labeled compound and allows the unique identification of

28 Idioblasts were supplied with various (14)C-labeled compounds and examined by micro-autoradiography

29 analysis and that assessment of purities of labeled compounds and metabolic labeling patterns requir

30 T) enzymatic assays, which typically rely on labeled compounds and plate readers, are important for d

31 ond scalar coupling is investigated in (15)N labeled compounds and the stability of the IMHBs is corr

32 this review the applications of isotopically labeled compounds are discussed and put into the context

33 ively expensive and time-consuming, and many labeled compounds are not available in pure form.

34 Stable isotopically labeled compounds are regularly used as internal standar

35 Isotopically labeled compounds are utilized to confirm the assignment

36 By giving a stable isotopically labeled compound as a substrate, the biological system w

37 that utilizes positron-emitting radioisotope-labeled compounds as PET radiotracers that are commonly

38 magnitude and orientation information using labeled compounds, as well as the structure elucidation

39 The use of isotopically labeled compounds assisted in correcting analyte losses

40 Increased cell uptake of these two labeled compounds at stimulated iNOS levels, as well as

41 We prepared seven (99m)Tc/Re-labeled compounds by attaching known Tc/Re chelating age

42 is no study evaluating the incorporation of labeled compounds by bacteria at single-cell levels usin

43 t that the cellular uptake of stable isotope-labeled compounds by bacteria can be probed at the singl

44 es of Ir-catalyzed C-H borylations, uniquely labeled compounds can be prepared.

45 elf-supported on an aqueous solution of C2F5-labeled compounds causes the recruitment and immobilizat

46 Dual-labeled compounds containing nuclear and near-infrared f

47 Use of the labeled compound Cp(2)Ta((13)CH(2))(H) shows that the po

48 database for the analysis of uniformly (13)C-labeled compounds, currently contains 455 metabolites, a

49 specific activities, and the pattern of 13C-labeled compounds detected by NMR spectroscopy cumulativ

50 gradation tests with radio or stable isotope labeled compounds enable the detection of the formation

51 the MS/MS spectra of the native and U-(13)C-labeled compound enabled the assignment of the number of

52 MS/MS) have circumvented the requirement for labeled compounds, enabling assessment of a substantiall

53 the use of very low doses of a radionuclide-labeled compound for imaging studies or for assessing pl

54 The use of positron emitter-labeled compounds for somatostatin receptor imaging (SRI

55 tate the development and comparison of (90)Y-labeled compounds for targeted radiotherapy.

56 Using a d(5)-labeled compound free of isobaric interferences in DOM,

57 amylcysteinylglycine) and the stable-isotope labeled compound (GSX, gamma-glutamylcysteinylglycine-(1

58 tamyl-cystein-glycin] and the stable-isotope labeled compound [GSX, gamma-glutamyl-cystein-glycin-(13

59 r allografts demonstrated that all four F-18-labeled compounds had a high tumor uptake (2.5-3.7% ID/g

60 Studies of isotopically labeled compounds have been fundamental to understanding

61 Hydrogen isotopically labeled compounds have extensive utility across diverse

62 PET and appropriately labeled compounds have the ability to provide informatio

63 i) the use of (13)CO(2) for the synthesis of labeled compounds; (iii) isocyanates as alternative elec

64 Tumor targeting of the lead (227)Th-labeled compound in vivo was performed in CD20-expressin

65 erformance liquid chromatography analysis of labeled compounds in arterial plasma, had no significant

66 Biodistribution studies of the iodine-125-labeled compounds in MDA-MB-231 mouse xenografts exhibit

67 udies were done after the injection of 99mTc-labeled compounds in nude mice bearing tumors.

68 valuable tool for the synthesis of deuterium-labeled compounds in pharmaceutical and mechanistic stud

69 s requires careful analysis of recoveries of labeled compounds in the appropriate eluate fraction.

70 and output fluxes; only the fractions of the labeled compounds in the input and output fluxes are var

71 Other (13)C-labeled compounds included glutamate, aspartate, glutami

72 Multiple (13)C-labeled compounds, including (13)C-bicarbonate, (13)C-gl

73 ing, the sensitive detection of isotopically labeled compounds incorporated into proteins of individu

74 Here, we show that (18)O-isotopically labeled compounds indicate that microbially produced DOM

75 The incorporation of radioactivity from 14C-labeled compounds into metabolic intermediates and total

76 ytical mass spectrometry, the use of tritium-labeled compounds is a key technique all along drug disc

77 topomers in a labeled compound or mixture of labeled compounds is an example of this problem that is

78 tion studies in rats indicated that the F-18-labeled compounds localized in brain regions with high c

79 measure individual radiation doses of (90)Y-labeled compounds noninvasively.

80 he second method employed two stable isotope-labeled compounds: one for calibration and the other for

81 ment of the distribution of isotopomers in a labeled compound or mixture of labeled compounds is an e

82 ul starting point for the synthesis of (18)F-labeled compounds prepared by the coupling of N-succinim

83 periments using (17)O and (18)O isotopically labeled compounds prove that this compound is a key inte

84 The analysis of the J(HN) couplings in (15)N-labeled compounds provides a simple and efficient method

85 absorbed dose to the renal cortex for (90)Y-labeled compounds retained within that subregion is appr

86 In vitro, the (18)F- and (68)Ga-labeled compounds showed rapid internalization in LS174T

87 synthesis and evaluation of an indazole-spin-labeled compound that was designed as an effective chemi

88 the pathway was followed by using deuterium-labeled compounds that could be identified by using GCMS

89 f various lengths, giving a mixture of (13)C-labeled compounds that remain virtually unchanged in the

90 In comparison to ions, noble gases, and labeled compounds, three aspects stand out.

91 rk describes the first application of (37)Cl-labeled compounds to isotope dilution mass spectrometry

92 on of beta-radiation associated with [(14)C]-labeled compounds to monitor the development of the conc

93 and DMSO-d(6) solvents in selectively (13)C-labeled compounds, to model the C1-C2-N2-C1' torsion ang

94 benzene and several easily synthesized (13)C-labeled compounds using (13)C-labeled iodomethane as the

95 Lung uptake of the (99m)Tc-labeled compound was markedly reduced in rats with pulmo

96 This labeled compound was taken up and metabolized by a cultu

97 Notably, <1 dpm (0.45 pCi) of (14)C-labeled compound was used in each assay, which is well b

98 A series of (13)C-labeled compounds was employed to investigate this biosy

99 In vivo localization of the respective (18)F-labeled compounds was evaluated by biodistribution studi

100 Methods: A small series of (125)I-labeled compounds was synthesized from tin precursors to

101 As a part of these studies, C(19)F3-labeled compounds were characterized and calibrated for

102 The (99m)Tc(CO)(3)-labeled compounds were injected into SCID mice bearing D

103 radiochromatograms simultaneously when (14)C-labeled compounds were injected into the gas chromatogra

104 d, and the corresponding tritiated and (11)C-labeled compounds were synthesized.

105 The corresponding 18F labeled compounds, which can be prepared readily, showed

106 of weanling rats to the stable isotopically labeled compound will be necessary to conclusively deter

107 as determined using a reference set of (14)C-labeled compounds with a range of potential environmenta

108 It provides facile and rapid access to (11)C-labeled compounds with carbon-11 attached at various hyb

109 To this end, four (14)C-labeled compounds with different biodegradation and sorp

110 However, synthesis of the labeled compounds with exclusive site selectivity and/or