ライフサイエンスコーパス: labile

1 2+) cluster bound at the C-terminal motif is labile.

2 ger time periods, palindromes are remarkably labile.

3 ortion of the CaP dissolved in each soil was labile.

4 pH 3.8, of which approximately only 33% was labile.

5 period of reconsolidation during which it is labile.

6 ed with signal perception are evolutionarily labile.

7 irculating glucose and lysine is also stress labile.

8 to obtain the chiral amides, aldehydes, and labile 1,2-diketones.

9 The C-telopeptide aldol dimers formed labile addition products with glucosylgalactosyl hydroxy

10 med that the imine bond is rather chemically labile allowing a self-correction mechanism until thermo

11 these memories can "destabilize" and become labile, allowing a transient "reconsolidation" window du

12 gands in the present An(IV) complexes proved labile, allowing for the electronic features of these co

13 tivity depends on the stabilization of their labile alpha subunit.

14 metabolically stable bioisosteres to replace labile amide bonds of the peptide.

15 urea-linking group without decomposition of labile amino acids such as Asn, Gln, Trp, Cit, and thean

16 The extinction of fear, however, is labile and a number of factors, including stress, cause

17 nally inert, while the two acetonitriles are labile and allow asymmetric transition metal catalysis.

18 d by a biphasic model with approximately 61% labile and approximately 39% stable fractions at tempera

19 The zwitterion is highly labile and by visible or IR irradiation rearranges via a

20 havior of 1-4 reveals that these adducts are labile and can reversibly dissociate to free carbenes an

21 By completely eliminating the labile and expensive components in traditional PSCs, the

22 esting that this conserved enzyme is folding-labile and may be a useful endogenous model for investig

23 rieval of the drug-cue memory, which becomes labile and must be reconsolidated into long-term storage

24 ntal data characterizing the behavior of the labile and naturally occurring Ni fraction by implementi

25 ation transfer interplays between the water, labile and non-labile protons, and the experimental resu

26 adequate quantification is the separation of labile and permanently bound heme and its high aggregati

27 ignificantly increased stocks of soil total, labile and recalcitrant organic C and N (SLOC, SLON, SRO

28 e find that the PGL-3 phase is intrinsically labile and requires a second phase for stabilization in

29 pool model, we then explored changes in soil labile and stable C decomposition along the thaw sequenc

30 e and the location of O-acetylation which is labile and susceptible to migration.

31 process by which reactivated memories become labile and susceptible to modifications.

32 n because NCU(IV) species are expected to be labile and susceptible to oxidation.

33 nalyses suggested that this 12-mer is highly labile and that apparent on-MHC trimming rates are alway

34 2+) concentrations and agreement between DGT-labile and the maximum dynamic concentration ( c(max)(dy

35 Newly learned motor skills are initially labile and then consolidated to permit retention.

36 In contrast, when particles were labile and turnover rates were high, aggregation promote

37 The phosphorus labile pool (P(labile)) and its desorption kinetics were simultaneously

38 (1-240 h), which allowed the estimation of P(labile), and the system response time ( T(c)).

39 When memories are retrieved they become labile, and subject to alteration by a process known as

40 -H bonds in the presence of more oxidatively labile aromatic functionalities remains a major unsolved

41 Covalent capture of these labile assemblies provides access to unprecedented archi

42 The number of labile atoms (those from -OH, -NH, =O, and -COOH groups)

43 a pH 7.0 soil inoculated with C. violaceum, labile Au concentration increased from 0 to 15%.

44 In the same soil adjusted to pH 7.5, labile Au concentration increased up to 29% over the sam

45 auxin can be compromised by the breakdown of labile auxin-related compounds during sample preparation

46 a second segment, 15-25 WT, forms non-toxic labile beta-sheets.

47 rovesicle particles by which a metabolically labile bioactive lipid can travel from cells in response

48 ts that do not result in damage of thermally labile biological samples.

49 drolysis of NB moieties containing different labile bonds (i.e., ester, amide, carbonate, or carbamat

50 n stored in individual neurons is relatively labile, but it can be reliably stored in networks of syn

51 y are often described as acidic or thermally labile, but no evidence is available from direct measure

52 sitivity of Rsoil was strongly influenced by labile C additions.

53 In contrast, a single-input of labile C causes positive apparent priming effects in mor

54 Abundances of functional genes involved in labile C degradation decreased while those for stable C

55 implying a microbial preference for the more labile C fraction in the peat matrix.

56 utrient cycling, if not countered by greater labile C inputs.

57 t persistently warm winter soils can lead to labile C starvation and reduced microbial respiration, d

58 Changes in labile carbon (LC) pools and microbial communities are t

59 s community to directly introduce a pulse of labile carbon into sediment, we traced a priming effect

60 Additionally, the labile carboxylate group allows water to bind early in t

61 e nanometer-sized, biodegradable, and rather labile carriers (nanoobjects) consisting of a lipid bila

62 their high oxidation states and the general labile character of their metal-ligand bonds pose import

63 In a periodic environment, a labile character with a single component of plasticity i

64 To detect labile complexes of 40S subunits with RNA by DEER/PELDOR

65 The features of previously unexplored labile complexes of human 40S ribosomal subunits with RN

66 on Mn(II) ion are rare, as it usually forms labile complexes with polyaminocarboxylate-type ligands.

67 in situ extraction of metabolites including labile compounds from biological matrices in a biocompat

68 s MALDI afforded better detection of larger, labile compounds including nucleotides.

69 In addition, low concentrations of partly labile compounds pose a special challenge, supplemented

70 rine, a sample largely devoid of higher-mass labile compounds, 88 compounds were uniquely detected by

71 the formulation of microcapsules loaded with labile compounds.

72 The P(labile) concentration was then compared to that obtained

73 The incorporation of DGT-labile concentrations to reference toxicity mixture mode

74 uted largely to the effect of evolutionarily labile, convergent host associations that have resulted

75 thermodynamically stable whilst kinetically labile coordination complex to address this conundrum.

76 copper-binding tracker, results showed that labile copper is preferentially localized to the spore b

77 Labile copper mirrored the trends seen in the toxicity t

78 levels as well as to probe the depth of the labile copper pool in conjunction with DTDP provides a p

79 ntracellular environment, the nature of this labile copper pool remains elusive.

80 Mitochondria of eukaryotic cells contain a labile copper(I) pool localized in the matrix where also

81 tes that GdL(1) can detect basal, endogenous labile copper(II) ions in living mice.

82 neutralize beta-lactams via a hydrolytically labile covalent acyl-enzyme intermediate.

83 The low-complexity (LC) domain of Pbp1 forms labile, cross-beta polymers that facilitate phase transi

84 ide, carbonate, or carbamate) that served as labile crosslinks within step-growth hydrogels.

85 bolism, where lower GSH/GSSG ratios decrease labile Cu(I) availability without affecting total copper

86 FCP-1 imaging reveals a labile Cu(I) deficiency induced by oncogene-driven cellu

87 FCP-1 enables imaging of dynamic changes in labile Cu(I) pools in live cells in response to copper s

88 probe, FCP-1, for activity-based sensing of labile Cu(I) pools in live cells.

89 peratures to allow the analysis of thermally labile DBPs.

90 Whereas cationic PHODIPY is labile, decomposing to a phosphine over time, GADIPY is

91 oral organ number in early formed flowers is labile, demonstrating that floral meristem maturation in

92 ven efficacious in alleviating the burden of labile diabetes and preventing complications related to

93 re large quantities of sample are recovered, labile dissolved organic compounds may not be detected d

94 -litter can serve as an additional source of labile dissolved organic matter (DOM), which can promote

95 range of unique organic compounds, including labile dissolved organic sulfur compounds, were detected

96 analysis of SRDOM and other proteinaceous or labile DOM (Alg, PA, and Glu) revealed that DOM with hig

97 ion of fidgetin results in elongation of the labile domains of microtubules and faster axonal growth.

98 otubule-severing protein that pares back the labile domains of microtubules in the axon.

99 her enables axonal microtubules to have long labile domains, in part by outcompeting genuine stabiliz

100 ally through the integration of biologically labile domains, remain of great interest.

101 y surfaces for these transformations combine labile, dynamically formed cationic species with deeply

102 maintain robust decoding, but display highly labile dynamics, when synaptic connectivity is continuou

103 onments of iron and nickel were particularly labile (e.g., by simple vacuum drying) is an important s

104 somer present in an equilibrating mixture of labile enamines.

105 istered with or without a double-mutant heat-labile enterotoxin (dmLT) as an adjuvant, in Bangladeshi

106 era toxin (CT) from Vibrio cholerae and heat-labile enterotoxin (LT) from enterotoxigenic Escherichia

107 e toxin (with or without genes encoding heat-labile enterotoxin), and Shigella spp.

108 Due to the labile ester containing link, this prodrug is converted

109 at least a fraction is incorporated through labile ether bonds.

110 ironment in solid tumors, but exploiting the labile extracellular pH differences between cancer and n

111 enhancing recruitment of Integrator or Heat Labile Factor to snRNA or RDH genes, respectively.

112 ion in iron homeostasis via sequestration of labile Fe(2+) into vacuolar compartments.

113 We found that the intracellular, labile Fe(2+) pool was higher under anaerobic conditions

114 ed by a prompt increase of the intracellular labile Fe(II) pool (LIP).

115 increasing number of examples of inherently labile Fe-S clusters whose compositional instability may

116 ent to empower enzyme function, and also how labile ferrous iron contributes to iron-dependent cell d

117 , we review recent insights into the role of labile ferrous iron in biology and disease, and describe

118 s of increased oxidative stress and elevated labile ferrous iron levels.

119 Recent insights into the structural basis of labile fibrils and potential mechanisms by which these r

120 more stable assemblies, including so-called labile fibrils, hydrogels, and pathological amyloids.

121 ronmental niches are highly phylogenetically labile for both seedlings and adult trees, with closely

122 The predominance of a relatively labile form of U((IV)) also provides an opportunity for

123 that this is avoided by precisely balancing labile forms of synaptic plasticity with more stable for

124 sruption of its homeostasis, particularly in labile forms that can contribute to oxidative stress, is

125 When present in excess and in nonphysiologic labile forms, iron is toxic to the kidneys and multiple

126 .5kJ/mol respectively for the stable and the labile fractions.

127 zeolites reveals a surprisingly dynamic and labile framework, where rapid and reversible bond breaki

128 with low-density silica layers connected by labile Ge-rich units into material with new topology.

129 blanks suggesting significant loss (36%) of labile GOMTK from the denuder or inlet.

130 specific manner (e.g., fluorophores or photo-labile groups).

131 conditions, which even includes highly acid-labile groups, results from a hitherto unexploited shift

132 A more acid-labile HA also conferred a small reduction in sensitivit

133 t, which has a high demand for haem, reduced labile haem in the nucleus and increased stability of th

134 hese unprecedented functions of exchangeable/labile heme and heme proteins should be of interest to b

135 scribe new, additional roles of exchangeable/labile heme as functional inhibitors and activators.

136 are emergent, critical roles of exchangeable/labile heme in signal transduction.

137 eme levels, here we investigated the role of labile heme in the regulation of mitochondrial biogenesi

138 ge, we show for the first time that cellular labile heme is critical for the post-translational regul

139 ing the blood stage of Plasmodium infection, labile heme is detoxified in RPTEC by HO-1 and FTH, prev

140 Quantitative analysis of labile heme is of fundamental importance to understandin

141 ium falciparum, we have quantified cytosolic labile heme levels in intact, blood-stage parasites.

142 bled controlled modulation and monitoring of labile heme levels, here we investigated the role of lab

143 Our findings indicate that a labile heme pool ( approximately 1.6 microM) is stably m

144 Consequently, we found that labile heme regulates mitochondrial biogenesis and cell

145 s, it enters a biologically available state (labile heme), in which it is loosely associated with pro

146 to be an important regulatory molecule (as "labile" heme) for diverse processes such as translation,

147 Here, NPSs containing labile heteroatom hydrogens were evaluated for HDX react

148 the compound LQZ-7, contains an undesirable labile hydrazone linker and a potentially nonfunctional

149 tide conjugated with doxorubicin via an acid-labile hydrazone linker as a function of local pH and ti

150 aracterization of compounds by the number of labile hydrogen and oxygen atoms in the molecule, which

151 The number of labile hydrogens (those from -OH and -NH groups) serves

152 gmentation spectra but also by the number of labile hydrogens that can be measured using the hydrogen

153 e saturation transfer (CEST) property of the labile hydroxyl group protons on maltitol (malCEST).

154 50% within 24 h, which indicates that CoA is labile in solution; however, degassing the sample with h

155 We analysed both the labile inorganic P (PILAB ), a proxy of the pool involve

156 Adding 'labile INR' to ATRIA, ORBIT and HEMORR2HAGES improved th

157 ve electrospray ionization (ESI) can disrupt labile interactions.

158 stroke, bleeding history or predisposition, labile international normalized ratio, elderly, drugs/al

159 stroke, bleeding history or predisposition, Labile international normalized ratio, elderly, drugs/al

160 eductase (RNR) activities and/or reduces the labile intracellular zinc ion pool.

161 been demonstrated so far due to their highly labile ionic structure and low phase stability.

162 CBP1-deleted hepatocytes exhibited increased labile iron and production of reactive oxygen species (R

163 The acid-labile iron and sulfide content analyses in conjunction

164 oietin receptor agonist reported to decrease labile iron in leukemia cells.

165 om C57BL/6 mice not only decreases total and labile iron levels but also leads to changes in the expr

166 tically, by targeting the expanded cytosolic labile iron pool (LIP) of the cancer cell.

167 suggest a putative role of HFE in regulating labile iron status in the brain, and mutation in H67D pe

168 revealed that Ent can chelate intracellular labile iron that is required for neutrophil oxidative re

169 mbocytosis, we observed a Mk bias, decreased labile iron, and decreased proliferation relative to wil

170 ogenic lead makes up a substantial amount of labile lead in today's environments.

171 Mechanically labile ligands dampen platelet activation, and the onset

172 However, short half-lives of such labile ligands due to nuclease attack and limited cellul

173 We found that hydrolysis of the acid-labile linker is incomplete because the pH range of 4-7

174 oporous MOFs with robust metal nodes and pro-labile linkers were initially synthesized.

175 that encode the heat-stable (ST) and/or heat-labile (LT) enterotoxins, as well as surface structures,

176 al processes selectively remove or transform labile material, effectively altering the composition of

177 ion of conformation-specific binders against labile membrane proteins or protein complexes and allows

178 ew gentle approach for the reconstitution of labile membrane-protein complexes, and used it to recons

179 The labile memory could then be weakened by an extinction pr

180 n which transient neural activities of early labile memory in the MB are consolidated into stable LTM

181 e olfactory learning forms several phases of labile memory to associate an odor with coincident punis

182 ly isolating melanosomes and profiling their labile metabolite contents.

183 hic biofilm presents a non-negligible highly labile metal pool with important potential for contrasti

184 wn to reliably determine the fraction of the labile metals species.

185 Nutrient enrichment increased production of labile microphytobenthos carbon, which stimulated degrad

186 his approach, but sufficient to increase the labile microtubule mass of the axon, thereby increasing

187 stabilize the microtubules, but to increase labile microtubule mass to levels more conducive to axon

188 y provides information about the presence of labile modifications via neutral loss fragments in addit

189 varying the connectivity of multiple stimuli-labile moieties within these customizable linkers, YES/O

190 rm its indirect role in installing an alkali-labile moiety as the imprint.

191 ology to include ultrastructural details and labile molecular components of the once-living animal.

192 odology is suited to other configurationally labile molecules (for instance, hydrazones and imines),

193 nt, identified as the nonhumic, biologically labile, "N-peak", which may be responsible for stimulati

194 ester and substitution of the metabolically labile naphthalene with a haloaryl substituent.

195 of sialic acids is challenging due to their labile nature during sample preparation and ionization.

196 Moreover, their labile nature has proven to pave a way to nuclear polari

197 s limitation is often attributed to the heat-labile nature of Rca.

198 n active systems with gain. Furthermore, the labile nature of soap films leads to a regime in which t

199 ciation not previously observed owing to the labile nature of the interactions.

200 Due to the labile nature of this linkage, chemoenzymatic methods ha

201 an in situ K(d) value of ~80 L kg(-1) and a labile Ni amount of ~5 mg kg(-1), that is, ~13% of the N

202 Wetlands, however, also became a source of labile Ni to littoral zones, which was linked to reduced

203 This effect was smaller for AAs with less labile nitrogen atoms (i.e. 'source' AA).

204 Over half of AAs that have labile nitrogen atoms (i.e. 'trophic' AA) had higher del

205 n-conducting membranes(9), or generated from labile nitrogen-containing compounds (for example, nitra

206 ces of contamination, and show how to remove labile nitrogen-containing compounds from the nitrogen g

207 BMS-806 strengthened the labile, noncovalent interaction of gp120 with the Env tr

208 onent 2 (PGRMC2) is required for delivery of labile, or signalling haem, to the nucleus.

209 Labile organic carbon (LOC) fractions and related enzyme

210 els of soil moisture, nitrate, chloride, and labile organic carbon, influenced chlorination of SOM fr

211 hed by pristine carbonaceous preservation of labile organic features, a very high proportion of new t

212 g insights into interactions of bacteria and labile organic matter in marine environments.

213 n podsol soil-with consistent stimulation by labile organic matter that did overrule the negative eff

214 nfirm that anaerobic respiration, sparked by labile organic matter, mobilizes P in this seemingly wel

215 n nitrate and water were added together with labile organic matter.

216 ments increased labile organic P, moderately labile organic P, and highly stable organic P in the 0-2

217 , while NPK and NPK + S treatments increased labile organic P, moderately labile organic P, and highl

218 ical procedures can be used to represent the labile P across different soils.

219 Increases in labile P generally coincided with decreased stability an

220 ommonly used as a representation of the soil labile P pool, overestimated the desorbable P concentrat

221 lated to antigen processing, could trim this labile peptide from preformed MHCI complexes as efficien

222 nanocrystals that form in situ in the water labile phase of the biphasic glass ceramic.

223 et of LPS chemotypes harboring spontaneously labile phosphoethanolamine (PEtN) modifications connecte

224 fluoridated CKI1RD (a stable analogue of the labile phosphorylated form) were identical and similar t

225 The plant flavonoid dogma proposes that labile plant flavonoid carbocations (PFCs) play vital ro

226 ted history of systemic allergic reaction to labile plant food allergens and on age-matched controls

227 The heat-labile plasma protein, fibronectin, inhibited PF4 bindin

228 Labile plasticity in a complex quantitative character is

229 s ability to contract by folding, becoming a labile polymer.

230 rvations explain how reversible formation of labile polymers by the Pbp1 LC domain enables the protei

231 The phosphorus labile pool (P(labile)) and its desorption kinetics were

232 oils and evaluating the availability of this labile pool is critical to understanding the underlying

233 rrect functioning of cells requires that the labile pool of chelatable "free" iron be tightly regulat

234 Manure impacts labile pools of soil organic carbon (SOC) and nitrogen (

235 suggest that cellular copper also exists in labile pools, defined as loosely bound to low-molecular-

236 2(NTD) induces unfolding by TonB1 of a force-labile portion of the plug domain that normally occludes

237 utively process arachidonic acid into highly labile prostaglandin E(2) (PGE(2)).

238 the sulfonyl moiety, which serves as a base-labile protecting group and confers crystallinity to the

239 valent interactions and efficiently transmit labile protein complexes.

240 astasis-promoting transcription factor, is a labile protein that is degraded through the ubiquitin pr

241 Here, we demonstrate that MAF1 is a labile protein whose levels are regulated through the ub

242 interplays between the water, labile and non-labile protons, and the experimental results are rationa

243 by pai-pai stacking interactions between the labile pyridine ligands of the nanosheets.

244 etin knockdown adds microtubule mass that is labile (rather than stable), thereby better recapitulati

245 of the second; however, only 40 and 28% were labile, respectively.

246 veral advantages compared with standard heat-labile reverse transcription methods.

247 subunit models showed that a likely site for labile RNA binding is a cluster of positively charged am

248 Instead, a labile salt bridge acts as an incessantly active "agitat

249 n lysosomes by competitively displacing this labile sialidase from PPCA.

250 This strategy was not as effective with labile sialylated structures; instead, it was observed t

251 from hyperpolarized "structural" waters and labile side-chain protons; and the possibility that fast

252 ion studies in which potential metabolically labile sites on compound 1b were removed or modified, re

253 f these methods, particularly when targeting labile sites.

254 But the decomposition of labile SOC was similar in warmed plots compared to the c

255 ganisms, act as major agents for decomposing labile soil organic carbon (e.g., cellulose).

256 Accordingly, the size of labile solid phase-bound phosphorus pool and the rate at

257 sis for the molecular level interrogation of labile SOM and C-cycling processes in soils.

258 tly been used to study the transformation of labile SOM, however these are still too complex to exami

259 ass Spectrometry (FT-ICR-MS), as a proxy for labile SOM.

260 he contributions of the fraction of the ASCP-labile species varied from 43 to 63% (Cu), from 32 to 42

261 eration and synthetic exploitation of such a labile species.

262 consolidated memories can enter a temporary labile state and require restabilisation, known as recon

263 core of three beta-strands and shorter more labile strands at the termini.

264 e scaffolds were designed to be rotationally labile such that they produced light only when paired wi

265 , the heterogeneity of modifications and the labile sulfate group present major challenges for liquid

266 molecules, including the characterization of labile sulfated functional groups.

267 high mobility resolution and preservation of labile sulfo modifications afforded by gated-TIMS MS ana

268 ial for cells to maintain adhesion on ligand-labile surfaces, and might also play a role in the migra

269 = Cl, Br) owing to their highly dynamic and labile surfaces.

270 dioxygenation of alkynes to highly demanding labile synthons, 1,2-diketones, and/or acids.

271 However, the small sizes of AIPs and labile thiolactone bond have hindered vaccine developmen

272 -pinene-derived hydroperoxides are thermally labile; thus, analysis of particle-phase (hydro)peroxide

273 that heterometals such as bismuth stabilize labile Ti-oxo sulfate clusters in aqueous solution.[Ti22

274 at caused amino acid substitutions from ClO2-labile to ClO2-stable residues in the viral proteins, wh

275 a. Taxol) that is stable in cell culture and labile to Pd catalysts.

276 l microbial transformation of organic C from labile to persistent anabolic forms.

277 with the Escherichia coli double mutant heat-labile toxin (dmLT) adjuvant afforded modest (10-30%) pr

278 It has long been known that ETEC heat-labile toxin (LT) activates production of cAMP in the ce

279 d adjuvants including cholera toxin and heat-labile toxin (LT) are powerful manipulators of mucosal i

280 h delivery system (PDS) with or without heat-labile toxin (LT) from Escherichia coli or subcutaneousl

281 LTB) chimera admixed with double mutant heat-labile toxin (LT) LT-R192G/L211A (dmLT).

282 rised of a pentameric B subunit of ETEC heat-labile toxin (LTB) in lieu of the CTB pentamer and a don

283 either cholera toxin B-subunit (CTB) or heat-labile toxin (LTB), or phosphate-buffered saline (PBS) a

284 ization with chimera plus single-mutant heat-labile toxin [LT(R192G)] elicited strong serum anti-CfaE

285 al antigens, including CfaEB and a CfaE-heat-labile toxin B subunit (LTB) chimera admixed with double

286 Sociality is probably an evolutionarily labile trait that has arisen numerous times during mamma

287 llowed by the controlled installation of the labile transannular hemiacetal.

288 During sulfidation, labile U(VI) is known to reduce to relatively immobile U

289 Our identification of a new, labile U(VI)-persulfide species under environmentally re

290 while amyloplast-localized PGD3 activity is labile under heat stress conditions.

291 The COD complex proved substitutionally labile undergoing diene substitution with tetrahydrofura

292 hat the P-cluster can become compositionally labile upon oxidation and reversibly lose one or two Fe

293 ation - where stored memories become briefly labile upon retrieval - may offer a means to disrupt MRM

294 Retention of labile vitamins such as thiamine (vitamin B1) in NASA sp

295 The total U released exceeds labile water-soluble and exchangeable fractions in unrea

296 ent bonds in the zeolite chabazite (CHA) are labile when in contact with neutral liquid water, which

297 Here we demonstrate that the holoenzyme is labile, with the R1 subunit dissociating at low pH.

298 e the photostationary state of the thermally labile Z isomers through computational means to provide

299 Labile zinc ions can be difficult to detect with probes

300 es the determination of when, where, and how labile zinc pools are concentrated into or released from