ライフサイエンスコーパス: lability

1 gest this may explain the membrane potential lability.

2 markedly suppresses ribosome conformational lability.

3 ty to sensory stimuli, and greater emotional lability.

4 l structural changes associated with cluster lability.

5 polarity, structural diversity, and sulfate lability.

6 cleotides was probed using phosphodiesterase lability.

7 novel explanation of "high-energy" N-P bond lability.

8 copper toxicity could be explained by copper lability.

9 ult to prepare by other methods due to their lability.

10 to change and by emotional and interpersonal lability.

11 aling during retrieval would increase memory lability.

12 f exacerbations, asthma severity, and airway lability.

13 GT and widen the range of considered complex labilities.

14 nt rated oppositional behavior and emotional lability (-0.175, p = <.0001 and -0.178, p = <.0001).

15 Affect lability (11%) and sedation (9%) were the most common ad

16 vity (16.0 vs 3.0 days, P = .001), emotional lability (15.0 vs 3.5 days, P = .002), noise sensitivity

17 Because of the ligand lability, 2 also undergoes hydrogenolysis and rapid exch

18 person-level risk score in OBP and with mood lability (a predictor of BD) across the sample.

19 common symptoms are hyperactivity, emotional lability, a below average intelligence quotient, and sho

20 We also assessed whether affective lability, aggressive or impulsive traits explain childho

21 ntially toxic Cu(I) ion, while their kinetic lability allows facile metal transfer.

22 between sex of the fetus and maternal airway lability among pregnant women with asthma.

23 scussed in the context of predictions of the labilities and bioavailabilities of the metal species.

24 provided complementary evidence about OSCs's lability and "artifacts" formation during the analytical

25 The N-linker region has high mechanical lability and acts as the primary stretch-sensor in twitc

26 While affective lability and anxiety/depression were elevated throughout

27 g particle size and mineral composition with lability and bioaccessibility in mine tailings subjected

28 ar, we include the competition between viral lability and Brownian motion.

29 The simultaneous evolutionary lability and conservation of the network underlying wing

30 viour and discuss it in the context of metal lability and coordination changes.

31 Gd kinetic lability and cytotoxicity studies further confirm stabil

32 over, the SAR domain confers both functional lability and DegP-mediated proteolytic instability on th

33 tiffening that can exacerbate blood pressure lability and diastolic dysfunction under stress.

34 The simultaneous evolutionary lability and genetic complexity of host plant use in the

35 en limited by several factors, including the lability and high cost of miRNA mimics.

36 Acid lability and improved ligation efficiency were introduce

37 alcatakely reveals a degree of developmental lability and increased morphological disparity that was

38 nsolidated aversive memories triggers memory lability and induces a plasticity-dependent reconsolidat

39 Anion lability and influence on the iron affinity and reductio

40 The mean scores for lability and intensity for each affective domain for pat

41 ning T251I and P587L induces extreme thermal lability and leads to synergistic nucleotide and DNA bin

42 to the fine-tuning of emotional stability or lability and may play a role in bipolar disorder.

43 tion, oromotor/oculomotor apraxia, emotional lability and mutism in patients after infratentorial inj

44 coordination equilibria, (iii) substitution lability and operative mechanisms for water exchange, (i

45 We conclude that oxygen lability and poor repair of Por and Oor are major contri

46 help reveal evolutionary pattern within this lability and potentially identify the changes that have

47 dala, two established markers of fear memory lability and reconsolidation.

48 ction of the pathways that regulate synaptic lability and stabilization, and suggest potential approa

49 H2), are consistent with a high substituent lability and the accessibility of both 1,1- and 1,2-subs

50 eved to have the greatest effect on C-O bond lability and therefore the photochromic properties.

51 ss suggest that fauna prefer PHY, due to its lability and/or toxins associated with ASB; this may acc

52 y tested whether childhood trauma, affective lability, and aggressive and impulsive traits predicted

53 A) that utilizes the simultaneous stability, lability, and directionality of metal-ligand bonds to dr

54 iastolic function, augmenting blood pressure lability, and elevating cardiac metabolic demand under s

55 vels of hyperactivity/impulsivity, emotional lability, and impairment in males and females with ADHD,

56 youths without anxiety/depression, affective lability, and mania (and with a parent with older age at

57 al measures of anxiety/depression, affective lability, and mania are important predictors of new-onse

58 developmental experimentation and structural lability, and may provide evidence of a critical link to

59 uding chorea, hyperactivity, tics, emotional lability, and obsessive-compulsive symptoms, can occur i

60 e EIIIA segment, evidence for conformational lability, and peptide sequences for probing EIIIA functi

61 /depression, baseline and proximal affective lability, and proximal subsyndromal manic symptoms (p<0.

62 s gas exchange, decreases pulmonary vascular lability, and reduces pulmonary inflammation.

63 surfactants, such as CMCs, solubility, acid lability, and stability were studied.

64 s of Ag were linked to higher DGT-determined lability, and this varied as a function of aging and rel

65 bon was related to its original quantity and lability, and was enhanced by changes in microbial physi

66 is responsible for the production of the low-lability AP.

67 erienced by women using HC (irritability and lability) are not captured by a screening tool for clini

68 buse predicted both aggression and affective lability as well as SI variability, but not impulsivity.

69 However, its lability at 37 degrees C has limited its therapeutic pot

70 ysis supported the hypothesis that affective lability at baseline predicts a new-onset bipolar spectr

71 domain plays a key role in regulating Nrdp1 lability by promoting its assembly into an oligomeric co

72 s associated with ventricular repolarization lability by using the QT variability index (QTVI), defin

73 karst-associated increases in organic matter lability cause shifts in biogeochemical processes toward

74 Across groups, mood lability correlated negatively with rsFC between IFG and

75 rored the trends seen in the toxicity tests; lability decreased with increasing DOC concentration and

76 Peak expiratory flow lability, defined as percent daily maximum minus the min

77 enever the time is replaced with the product lability degree times t.

78 substrate, the variably increased rate of NH lability dictates a significant loss of dynamic stabilit

79 to it as GNARLE (Global Nanos Associated RNA Lability Element).

80 However, owing to their lability elimination of sulfate groups upon desorption/i

81 associated with bipolar disorder: emotional lability, emotional dysregulation, and heightened reward

82 imilar to our studies on BaTiO3-xHx, hydride lability enables a low temperature direct ammonolysis of

83 doethanol necessitated by the high degree of lability endowed by the aryl azide moiety.

84 Future affective lability factor scores were predicted in both samples by

85 eline, were used to predict future affective lability factor scores, using regularized regression.

86 ural predictors of future-specific affective lability factors is a step toward identifying objective

87 y, pain, cognition, depression and emotional lability, fatigue, sleep disturbance, head drop, prevent

88 alnexin displayed significant conformational lability for a chaperone and that heat treatment and cal

89 s, the present study determines whether this lability has consequences for the passive stabilization

90 Such patients had higher glycemic lability, hemoglobin A1C levels, and Acute Physiology an

91 tes of enantiomers and common conformational lability, high fidelity homochiral or heterochiral self-

92 inherent robustness with a highly regulated lability, how it adapts to both rapidly and slowly chang

93 Curcumin is known from its lability, however, the structural curcumin transformatio

94 of transpeptidation and favoring the kinetic lability hypothesis.

95 inattention, memory problems, and emotional lability/impulsivity were significantly improved with 50

96 dings provide a substrate for increased mood lability in adolescents, and provide a substrate by whic

97 studies provide evidence for conformational lability in and around the alpha-subunit 3-10 helix at r

98 Directed investigation revealed surprising lability in CDX2 occupancy of the genome, with redistrib

99 of membrane proteins is complicated by their lability in detergent micelles and by their association

100 M7 instead of TM2) results in conformational lability in detergent solution and more rapid cell-surfa

101 d hypomania in bipolar disorders; trait mood lability in major depressive disorder.

102 esults in increased emotional reactivity and lability in mice.

103 phenotype strongly contributes to affective lability in patients with BD.

104 Despite its lability in solution, this compound forms homochiral sin

105 Greater lability in terms of anger and anxiety and oscillation b

106 ar mechanisms of stability at the expense of lability in the amygdala of rats.

107 lysis due to their isobaric nature and their lability in the gas phase, as both types of peptides dis

108 ults identify loci of genetic and epigenetic lability in the mammalian genome but argue against a dir

109 d confounding effects when measuring element lability in the presence of nanoparticles.

110 This local-context-driven lability in the representation of complex sounds-a modul

111 dition, they suggest surprising evolutionary lability in traits previously interpreted to be conserva

112 imed to identify markers of future affective lability in youth at bipolar disorder risk from the Pitt

113 study was to map the determinant conferring lability in Zn(II) binding by using finger pair chimeras

114 Kinetic lability in Zn(II) binding was mapped to the alpha-helix

115 brain glucose correlated positively with the lability index (r = 0.67, P = 0.006).

116 s a significant interaction between glycemic lability index and average glucose level, and the odds o

117 to measure glucose variability, the glycemic lability index had the best discrimination for mortality

118 Higher glycemic lability index was not independently associated with mor

119 However, subjects with increased glycemic lability index, but lower average glucose values had alm

120 8.7) compared with those with lower glycemic lability index.

121 ude of glycemic excursions, and the glycemic lability index.

122 lly, as the serine residue promoting thermal lability is conserved among Mus musculus, Danio rerio, D

123 epigenetic metastability which confers this lability is due to the A(vy) transposable element.

124 triction to patients with critical metabolic lability is justified by the long-term need for immunosu

125 We conclude that apo A-I lability is required for HDL opacification, LF apo A-I d

126 d QT variability, a marker of repolarization lability, is associated with an increased risk for VT/VF

127 This lability may explain the absence of the [2Fe-2S]2+ clust

128 ylidene catalysts is hence due to low ligand lability, not inherently slow cycloaddition at the Ru=CR

129 interval: -19.4, -0.4) difference in airway lability observed between women carrying female fetuses

130 anxiety (odds ratio=0.43), and irritability/lability (odds ratio=0.38).

131 y switch the binding site affinities and the labilities of barriers on the track, creating an energy

132 The labilities of these dynamic ion pairs in solution are th

133 Thus, studies relying on the lability of 2-LTR circles are open to reinterpretation.

134 The increased lability of 6 is probably because, unlike the 2,6-dinitr

135 The acid lability of aliphatic ketals, which often serve as prote

136 We exploited differences in the acid lability of amide bonds within high-molecular-weight (HM

137 cidification increased the retrieval-induced lability of an aversive memory.

138 ns that were fundamental to the evolutionary lability of angiosperm reproduction, and hence to their

139 tenuates arterial baroreflexes, and leads to lability of arterial blood pressure, damage to cardiac m

140 cardiovascular reflexes while also producing lability of arterial pressure, damage to cardiac myocyte

141 n which Cfd1-Nbp35 interaction increases the lability of assembled FeS on the Nbp35 scaffold for tran

142 The lability of B=B, B-P, and B-halide bonds is combined in

143 during redox transformation and implies the lability of biogenic noncrystalline U(IV) species in the

144 he studies shows remarkable diversity in the lability of boutons depending on the cell type from whic

145 in particular lineages pointed to a striking lability of centromeric regions that distinguishes the e

146 to be lower as a consequence of the enhanced lability of clusters in the derivative proteins.

147 ent can effectively change the speciation or lability of contaminant metals (copper, zinc and cadmium

148 ion and were of limited use for reducing the lability of contaminant metals in good quality biosolids

149 ibody-targeted imaging, but the high in vivo lability of conventional chelates has limited its clinic

150 ociative ligand exchange mechanism where the lability of coordinated water dominates the reactivity w

151 This work compares the intrinsic lability of different sulfonate esters, identifying new

152 s in field settings to assess the source and lability of dissolved organic matter in situ.

153 verned by a combination of the abundance and lability of DOC exported from land to water and produced

154 The lability of DOM is thought to vary with age, with younge

155 in controlled experiments may depend on the lability of fewer key traits.

156 In contrast, the evolutionary lability of genetic sex determination in other groups re

157 To define the lability of genomic imprints during this dynamic period

158 The lability of H(-) in BaTiO3-xHx (x </= 0.6) allows H(-)/N

159 We discuss the evolutionary lability of histone methylation profiles and draw a dist

160 nique mode of cell migration elicited by the lability of integrin ligands.

161 gistic anion plays a role in controlling the lability of iron bound to FbpA in the transport process.

162 ire cluster in solution despite the relative lability of its constituents.

163 etained as the primary aconitase because the lability of its exposed cluster allows E. coli to sense

164 Experimentally, the lability of metal-bound acetates is greatest for Mn(III)

165 may potentially be useful surrogates for the lability of metals for all exposure routes.

166 Based on the heat-lability of MMS-induced base damage, an assay was develo

167 The adolescent age is associated with lability of mood and emotion.

168 Studies of the alkaline lability of oligodeoxynucleotides containing formamidopy

169 the effect of pathway length on evolutionary lability of pathway structure, we examined amino acid bi

170 ms (SNP) based on kinetic differences in the lability of perfectly matched (PM) and mismatched (MM) D

171 its biological relevance, the intrinsic acid lability of phosphoarginine (pArg) has impaired studies

172 erations, including antibody specificity and lability of phosphoepitopes, are covered, along with pot

173 ave temperature sensitivity varying with the lability of plant inputs.

174 terogeneous composition, ubiquitous isomers, lability of post-translational glycan modifications, and

175 , to enable a direct structural gauge of the lability of protons in a given material, which is correl

176 SEA-0400 stabilized dofetilide-induced lability of repolarization and suppressed early afterdep

177 in vivo, but added RRF does not increase the lability of ribosome-bound EF-G.

178 These findings highlight the lability of risk attitudes in macaques and support the h

179 Our study highlights the lability of RNAi pathways, even within well-studied grou

180 Long-term speciation and lability of silver (Ag-), silver chloride (AgCl-), and s

181 The lability of skeletal composition among octocorals sugges

182 Discrepancies were explicable by the heat lability of some mutants.

183 ous composition, large molecular structures, lability of sulfate attachments, and a lack of highly se

184 he matrix upon laser irradiation, reflecting lability of sulfo groups.

185 To identify the molecular basis for lability of T3D/T1L L3S2, we screened for hyperstable mu

186 itive to alteration of both the quantity and lability of terrigenous dissolved organic matter (DOM) d

187 stereoelectronic factors contributing to the lability of the "high-energy" N-P bond.

188 d (7)Li{(1)H} NMR spectroscopy, owing to the lability of the [Li(14)(O(t)Bu)(12)Cl](+) cation.

189 The acid-lability of the acetal groups allows the release of ther

190 erface influences the stability and pressure lability of the cage, despite its location being discret

191 was shown to be involved in the observed pH lability of the cluster, indicating that loss of this li

192 3 over the course of 12 h, demonstrating the lability of the Cr0-H2 bond.

193 the siRNA linked to the nanoparticle and the lability of the cross-linker are critical for efficient

194 The lability of the equatorial (eq) CH3CN groups in these co

195 The flexibility and lability of the Fe-BPh interactions in these complexes e

196 The lability of the formamide group required that nucleoside

197 an HO-1 (hHO-1) protein; however, due to the lability of the full-length form, a rapid purification p

198 Due to the lability of the glycosidic bond, 8-nitrodG cannot be inc

199 his lesion are quite indirect because of the lability of the glycosidic bond.

200 immunogens have been frustrated by both the lability of the gp120-gp41 interaction and the weak asso

201 nct figure-eight retains the configurational lability of the helicene precursor.

202 This change in redox status increases the lability of the heme cofactor leading to further suppres

203 CAAC, C1) and a bridging chloride donor: the lability of the latter elevates the reactivity of Ru-1 t

204 hree dirhodium compounds correlates with the lability of the leaving groups and corresponds to the ex

205 tion at vacant sites, enabled by the overall lability of the ligand sphere and the absence of ligand

206 transverse the cellular membrane but to the lability of the ligands on the dirhodium core.

207 signature of the coordinating cysteines and lability of the metal cofactor.

208 with the ion migration rate depending on the lability of the metal-ligand interactions [Pb(II) faster

209 We hypothesize that the cause of the lability of the N-glycosidic bond is due to the combined

210 ase within the MutY active site modulate the lability of the N-glycosidic bond.

211 The lability of the N-P bond is central to the physiological

212 However, conformational lability of the native serpin fold renders them suscepti

213 The lability of the NH(4+)-containing cage was also indicate

214 s the solvent polarity increased, so did the lability of the nitrosoamides.

215 The acid lability of the oxabicyclic structure was exploited to e

216 e synthesis (SPPS) due to the intrinsic acid lability of the P( horizontal lineO)-N phosphoramidate b

217 The results have implications on the lability of the peptide conformation in biological membr

218 The lability of the peroxidase results from oxidation of the

219 the lack of pHis-specific antibodies and the lability of the phosphoramidate (P-N) bond.

220 on the sulfur atom, we were able to tune the lability of the platinum-sulfur interaction of platinum(

221 The increased lability of the polysome-associated mutant HEXA mRNA sho

222 uced changes in HIF-1alpha is limited by the lability of the protein in normoxia.

223 ally and favor respectively the stability or lability of the receptor beta-arrestin complex, thus reg

224 as long been a challenge due to the inherent lability of the reduced cofactors.

225 vertex sites of the Au(140) core, where the lability of the slightly more ionic Au[bond]S bonds ther

226 We discuss how the lability of the species that make up the MOFs can affect

227 harides presents major challenges due to the lability of the sulfate modifications, as well as diffic

228 chemical transformation, confirming that the lability of the supported clusters appears to be a criti

229 Since the acid-lability of the thioamide prohibits on-resin thioester s

230 glycosaminoglycans is challenging due to the lability of their sulfate groups, the high heterogeneity

231 nal modeling at the DFT level shows that the lability of these bonds can be controlled by steric pres

232 We show that evolutionary lability of these colors is associated with both morphol

233 Both the hydrophobicity and hydrolytic lability of these silicates can be (independently) contr

234 The variability and lability of these virus-host complexes on fractionation

235 The lability of this family of proteins relative to [2Fe-2S]

236 The lability of this gold-thiol linkage upon exposure to oxi

237 he 0.6 state results from the conformational lability of unlocked ribosomes formed during translocati

238 o 8.8:1 in the summer months, reflecting the lability of viral-culture specimens transported during w

239 Our results highlight the evolutionary lability of xylem traits with climate, and the leading r

240 These results indicate that the kinetic lability of ZF1/2 in vivo is a key component of Zap1 zin

241 ome reference), Xi; (3) the flexibility, or "lability", of the molecule at equilibrium, Lambda; and (

242 mpaired hypoglycaemia awareness or glycaemic lability, or who already receive immunosuppressive drugs

243 han others, conferring a layer of phenotypic lability over a core of genotypic stability; this core d

244 chemically stable and have profoundly low Ag lability over extended periods.

245 ded that this more likely reflects increased lability over that of the alpha-subunit, and not the abs

246 Emotional lability, personality changes, psychosis, and mania are

247 ures of mania, depression, anxiety, and mood lability; psychosocial functioning; and parental age at

248 le glycosidic cleavage introduces a point of lability (pyranosyl-1-ene) that upon collisional activat

249 tanding of its biological targets due to the lability, reactivity, and "spectroscopic silence" that a

250 ountering acute heart failure or hemodynamic lability refractory to conventional therapy.

251 The conformational lability required for loop insertion must therefore be t

252 l, in which the base of SL1 has an optimized lability required to mediate a physical interaction betw

253 stricted to patients with critical metabolic lability resulting from the need for immunosuppression a

254 s) completed the Center for Neurologic Study-Lability Scale (CNS-LS) and an 11-point scale measuring

255 and depression (Center for Neurologic Study-Lability Scale (CNS-LS) and Patient Health Questionnaire

256 e >/=13 on the Center for Neurologic Studies-Lability Scale [CNS-LS]) were maintained, twice daily, o

257 er reductions in Center for Neurologic Study-Lability Scale scores than those receiving placebo (p <

258 th the validated Center for Neurologic Study-Lability Scale.

259 ession in forebrain causes higher "emotional lability" secondary to a unique pattern of molecular reg

260 Zn2+ alone to apo-AP produces only the high-lability species with no subsequent structural change, s

261 Density characterization and heat lability studies indicated that the increased erythroid

262 comparatively little effect on quadricyclane lability, substitution at a bridgehead position with a m

263 rnalizing, subsyndromal manic, and affective lability symptoms.

264 the scores for the agitation/aggression and lability/tension factors.

265 ternal asthma, as assessed by greater airway lability, than is carrying a male fetus.

266 rom the 2-thio- and the 6-carboxyl groups, a lability that could, in turn, be useful for further chem

267 the wild-type enzyme and an increase in cold lability that is attributed to destabilization of the ac

268 rdination of mNT's [2Fe-2S] leads to cluster lability that is strongly dependent on the presence of t

269 However, because of its lability, the structure and properties of this larger co

270 tribution to tumor progression, and elevated lability through autoubiquitination contributes to the o

271 ge method in which we take advantage of this lability to controllably synthesize PbSe/CdSe core/shell

272 , and greater understanding of metal species lability to DGTs is needed before assuming equivalence b

273 dments that range along a gradient of carbon lability to four newly restored wetlands in western New

274 The range of DOC lability to microbes seems to depend on prior light expo

275 Permafrost and organic mat DOM had similar lability to photomineralization despite substantial diff

276 w that although the mutation confers thermal lability to the enzyme, the effect is relatively minor.

277 ProTides showing diminished carboxypeptidase lability translated to poor anti-HIV agents and vice ver

278 her SOC decomposition is driven by substrate lability under warming.

279 d upon mutation to stabilize the deamidation lability via a generally applicable orthogonal engineeri

280 dynamics, yet the underlying causes of niche lability vs. stasis are poorly understood.

281 This lability was apparently compensated by co-localization o

282 Ag lability was characteristically low in soils containing

283 The importance of cross-link lability was investigated by NaBH(4) reduction of the ra

284 The BgaS heat lability was investigated by ultracentrifugation, where

285 The generality of reversible lability was tested by applying the in situ esterificati

286 y (HPLC) resolution or, when configurational lability was too high, through VT-HPLC analysis on the c

287 To probe the origins of this conformational lability, we have performed hydrogen exchange measuremen

288 rlying Nrdp1 protein self-regulation through lability, we investigated the structural determinants re

289 mperatures of duplex DNA, and their cleavage labilities were determined.

290 monitored throughout and the speciation and lability were determined in both fresh and 3-month aged

291 ction time variability, timing and emotional lability) which can be examined in the HCP data and in f

292 een considered impossible due to their photo-lability, which actually makes aryl iodides popular star

293 her QTVI suggests ventricular repolarization lability, which can increase susceptibility to arrhythmi

294 unterintuitively, despite its substitutional lability, which is mechanistically required for coordina

295 spiratory-like rhythmic network activity and lability, which may play an important role in generating

296 These findings lead to the hypothesis that lability with respect to conformations separated by an o

297 idine and our observations on its unexpected lability with respect to its N-glycosidic bond when comp

298 e is characterized by extreme blood pressure lability with severe hypertensive crises, hypotensive ep

299 m Mn(3)MO(4) cubanes is controlled by ligand lability, with the Mn(IV)(3)CaO(4) OEC model being unrea

300 Together, these data reveal unexpected lability within the adipocyte PPARgamma cistrome and sho