ライフサイエンスコーパス: labor-intensive

1 in pathology, despite being highly time and labor intensive.

2 l validation of such phenotypes becomes very labor intensive.

3 oculture assay is however time-consuming and labor intensive.

4 making alloy development time consuming and labor intensive.

5 numbers of samples are still highly cost and labor intensive.

6 reas classical ASO-PCR is time-consuming and labor intensive.

7 e post-screen validation process is time and labor intensive.

8 es such as surgeries both time consuming and labor intensive.

9 cell counts and differentials of sputum are labor intensive.

10 Surveillance for VAP is subjective and labor intensive.

11 d mass spectrometry, which are expensive and labor intensive.

12 lieved to be highly accurate; however, it is labor intensive.

13 ome sequencing is still costly, lengthy, and labor intensive.

14 but, for the most part, they are costly and labor intensive.

15 most of these methods are time consuming and labor intensive.

16 tected compound; however, data mining can be labor intensive.

17 n-based single-copy assays are sensitive but labor intensive.

18 of structural labels is both computation and labor intensive.

19 dures, which are time consuming, costly, and labor intensive.

20 onitoring requires multiple samplings and is labor intensive.

21 This approach is simple and reproducible but labor intensive.

22 of IFA slides, which was both subjective and labor-intensive.

23 rting tether which can be time-consuming and labor-intensive.

24 n sequestration and that briquette making is labor-intensive.

25 ; however, their production is expensive and labor-intensive.

26 n are annotated manually, which is time- and labor-intensive.

27 ermining hVISA, but it is time-consuming and labor-intensive.

28 methods require purified proteins and/or are labor-intensive.

29 ther culturing combinations and is the least labor-intensive.

30 cing approaches are prohibitively costly and labor-intensive.

31 oylation sites is usually time-consuming and labor-intensive.

32 gas analysis in water is both expensive and labor-intensive.

33 ndard," although prohibitively resource- and labor-intensive.

34 ires specialized skills and equipment and is labor-intensive.

35 cal testing, which can be time-consuming and labor-intensive.

36 ession of marker genes can be subjective and labor-intensive.

37 ever, previous methods are both indirect and labor-intensive.

38 ng bacterial cultures are time-consuming and labor-intensive.

39 ng of processed tissue is time, resource and labor intensive(2,3).

40 scale due to several limitations, including labor-intensive agar plating and colony selection method

41 an entirely automatic fashion, thus avoiding labor-intensive analyses and potential intra- or interob

42 and liquid-liquid extraction (LLE) steps are labor intensive and are thus not practical for high-thro

43 for cell types of interest, but are costly, labor intensive and can limit investigation of important

44 tional methods, this technology is much less labor intensive and can provide accurate and reliable re

45 modulate these phenotypes in human cells is labor intensive and challenging to scale.

46 Performing sequential food challenges was labor intensive and could result in severe allergic reac

47 ng embryogenesis have been developed but are labor intensive and do not naturally integrate morphogen

48 nal CD8 T cell epitope discovery methods are labor intensive and do not scale well.

49 he need for radioactive isotopes and is less labor intensive and faster than the alternative PAGE wit

50 itional methods for measuring aerosol OP are labor intensive and have poor time resolution, with sign

51 nce of such cells often proves to be costly, labor intensive and ineffective.

52 he axonal projections of selected neurons is labor intensive and inherently limited by currently avai

53 t allow remote control of neurons are either labor intensive and invasive or indirectly coupled to ne

54 The method is less labor intensive and label-free with ease of monitoring t

55 ecording sleep behavior in these systems are labor intensive and low in throughput.

56 r regulatory motifs within a promoter can be labor intensive and may miss redundant, unprecedented or

57 entation and has the advantage of being less labor intensive and more repeatable.

58 Current approaches are labor intensive and mostly limited to elucidating high-a

59 anually collect relevant materials is rather labor intensive and often incomplete due to resource con

60 relations between IR and NMR signals and are labor intensive and possibly ambiguous.

61 side-chain resonance assignment, however, is labor intensive and prone to error.

62 ulting cell types are typically annotated is labor intensive and rate-limiting.

63 ved less attention as these screens are more labor intensive and require extensive resources.

64 ional single-cell data are often subjective, labor intensive and require prior knowledge of the biolo

65 ods are highly sensitive but time consuming, labor intensive and require sophisticated expensive inst

66 However, it is labor intensive and requires large volumes of human milk

67 easurement of colony-forming units, which is labor intensive and takes at least 24 h to perform but i

68 uctural information, data processing is very labor intensive and the results are often limited by the

69 ield of senescence/immortalization, but were labor intensive and the results were somewhat limited.

70 the current Sanger method is too expensive, labor intensive and time consuming to accomplish medical

71 er, the existing technologies are expensive, labor intensive and time consuming, posing significant l

72 Drawbacks are that the labeling process is labor intensive and time consuming.

73 ression screening; however, this approach is labor intensive and time consuming.

74 ts a logistical challenge, as the process is labor intensive and time consuming.

75 Those standard techniques are labor intensive and time-consuming.

76 edical records review; however, this is very labor intensive and vulnerable to misclassification.

77 ia luciferase reporter is significantly less labor-intensive and allows earlier detection of reactiva

78 TFs makes genome-wide profiling for them all labor-intensive and costly.

79 ance method, this technique is prohibitively labor-intensive and expensive, requiring repeated measur

80 '-is based on imaging methods that are slow, labor-intensive and expensive.

81 However, they are usually time-consuming, labor-intensive and expensive.

82 Current methods of estimating IFTA are slow, labor-intensive and fraught with variability and samplin

83 rometry-based proteomics remains subjective, labor-intensive and inconsistent between laboratories.

84 olation of EVs, it is highly time-consuming, labor-intensive and instrument-dependent for both resear

85 tion has been developed, but it is typically labor-intensive and low-throughput.

86 he needs of continual monitoring as they are labor-intensive and not easily integrable with low-volum

87 ions of these factors make immunoassays more labor-intensive and often challenging to validate in sup

88 rent batch cultivation methods are time- and labor-intensive and often fail to consider sophisticated

89 s for intraoperative histology are time- and labor-intensive and often introduce artifact that limit

90 cificity and multiplexing capability, can be labor-intensive and prone to human error, making them un

91 carry out this analysis are time-consuming, labor-intensive and require a high amount of solvents.

92 However, these techniques are relatively labor-intensive and require a significant amount of trai

93 The current SA detection methods are costly, labor-intensive and require bulky instruments.

94 n structure elucidation remain expensive and labor-intensive and require highly purified starting mat

95 Microscopy is, however, labor-intensive and requires a skilled technologist.

96 ed to automate this task which at present is labor-intensive and requires considerable informatics an

97 s, demanding peptide enrichment which can be labor-intensive and requires large amount of material.

98 One drawback of these screens is the labor-intensive and sometimes inconclusive process of ma

99 Hence, labor-intensive and thus costly experimental studies cou

100 ction (PCR), and gene microarrays, which are labor-intensive and time-consuming approaches.

101 same order of magnitude for that of the more labor-intensive and time-consuming cell-assay technique,

102 rentiation of Cryptosporidium species, it is labor-intensive and time-consuming compared with methods

103 vides a cost-effective solution to eliminate labor-intensive and time-consuming fluidic handling step

104 vides a cost-effective solution to eliminate labor-intensive and time-consuming fluidic handling step

105 e regulation of NPQ have relied primarily on labor-intensive and time-consuming generation of stable

106 was produced in 24 hours, compared with more labor-intensive and time-consuming hybridoma or recombin

107 ands by exponential enrichment (SELEX) was a labor-intensive and time-consuming process, but recent a

108 Large-scale sample collection is a labor-intensive and time-consuming process; the informat

109 haracteristics of individual EVs via FS is a labor-intensive and time-consuming task, usually limitin

110 nd individual strain identification, it is a labor-intensive and time-consuming technique.

111 g emerging CTL epitope mutations rely on the labor-intensive and time-consuming techniques of virus p

112 screening process can reduce the burden of a labor-intensive and time-consuming traditional literatur

113 izes presents a major challenge as it can be labor-intensive and time-consuming.

114 nalysis of the resulting fractions, which is labor-intensive and time-consuming.

115 unoassays for IFN-gamma, this assay is still labor-intensive and time-consuming.

116 However, it is labor-intensive and time-consuming.

117 by exponential enrichment (SELEX)) are often labor-intensive and time-consuming.

118 face cleaning and functionalization, remains labor-intensive and time-consuming.

119 nd the experimental determination of DDIs is labor-intensive and time-consuming.

120 arge amounts of material for analysis and is labor-intensive and time-consuming.

121 andard histologic methods is time consuming, labor intensive, and dependent upon investigators' exper

122 a small blood volume; (iii) is faster, less labor intensive, and less expensive; and (iv) can be rea

123 e probes and as a result are low throughput, labor intensive, and limited by probe placement.

124 However expert labeling is time and labor intensive, and the costs remain prohibitive for sc

125 tional saturation mutagenesis approaches are labor intensive, and the resulting TCRs may be cross-rea

126 ants by flanking sequence analysis is highly labor intensive, and therefore, libraries that do exist

127 personalized DC immunization is too costly, labor intensive, and time-consuming for large-scale vacc

128 chromatography, are complicated, costly, and labor-intensive, and alternative techniques that simplif

129 al issues; notably, they are time-consuming, labor-intensive, and are characterized by relatively low

130 , microinjection is a technically demanding, labor-intensive, and costly procedure with poor embryo v

131 f the UHPLC-HRAM-MS data is a very daunting, labor-intensive, and expertise-dependent process.

132 assays usually involves manual counting, is labor-intensive, and is subject to bias.

133 (NA) purification remains time-consuming and labor-intensive, and it takes extensive efforts to optim

134 taining; however, these approaches are slow, labor-intensive, and often fail to enable further geneti

135 onal promoter-repressor sets is complicated, labor-intensive, and often results in unanticipated cros

136 ols for the diagnosis of OSA in children are labor-intensive, and onerous, and remain unvalidated.

137 Conventional serological methods are costly, labor-intensive, and prone to misidentification, while c

138 ns, such processes are relatively expensive, labor-intensive, and require bulky and costly equipment.

139 d-standard" viral outgrowth assay is costly, labor-intensive, and requires large numbers of cells.

140 tect Mycobacterium tuberculosis are complex, labor-intensive, and technically challenging.

141 e of bronchoalveolar lavage fluids (BALF) is labor-intensive, and the delay involved in performing cu

142 ng BAC clones, generated by an expensive and labor-intensive approach.

143 ly automated, performs similarly to previous labor intensive approaches, provides consistent results

144 These labor-intensive approaches have struggled to keep pace w

145 field-conditions is hindered by traditional labor-intensive approaches that are prone to taxonomic a

146 ring demographics may effectively complement labor-intensive approaches, with the potential to measur

147 t present, these conversions remain time and labor-intensive as they require embryos to be injected w

148 s expensive, specialized instrumentation and labor-intensive assay and image processing procedures, w

149 with the ability to automate a historically labor-intensive assay is an appealing attribute for syph

150 ide triphosphates (dNTPs) employ reagent and labor-intensive assays utilizing radioisotopes in DNA po

151 uperinfection have involved a combination of labor-intensive assays with various rates of success.

152 o date, mAb quantification requires time and labor-intensive assays.

153 Previously, expensive and labor-intensive BAC-based techniques were used to sequen

154 hway, experimental studies generally require labor-intensive biochemical techniques.

155 mendous task of automating the important yet labor-intensive biocuration effort.

156 residue positions for probe incorporation in labor-intensive biophysical experiments such as chemical

157 SNPs, and the "curves" method, which is more labor intensive but also slightly more accurate.

158 h complexity immunoassays that are time- and labor-intensive but provide semi-quantitative results.

159 Only inaccurate and labor-intensive cell-free biochemical assays are current

160 ethod can be time-consuming because multiple labor-intensive centrifugations and washes with organic

161 ss monitoring method and can replace several labor-intensive chromatographic and colorimetric methods

162 The time-consuming and labor intensive compound separation and purification pro

163 nalysis of HIV diversity, but this method is labor-intensive, costly, and requires complex protocols

164 d for product identification can be time and labor intensive, creating a need for quick, inexpensive

165 olayer model has several drawbacks including labor-intensive culture process, unphysiological growth

166 GPCR target of interest has necessitated the labor-intensive development of cell lines stably express

167 ar on the American Community Survey (ACS), a labor-intensive door-to-door study that measures statist

168 agnification near-field (HN) images that are labor intensive due to a requirement for manual image se

169 hese compounds can progress to expensive and labor-intensive efficacy studies in mice, creating a 'bo

170 e use of the ViBE Bioanalyzer eliminates the labor-intensive effort of Western blot analysis and is d

171 in in human serum while also eliminating the labor-intensive efforts of Western blot analysis and is

172 rted in cis The current undertaking involves labor-intensive embryonic stem (ES) cell-based gene targ

173 f pairing antibodies is often cumbersome and labor-intensive even with the use of designed peptide-sp

174 r tubulin polymerization are low throughput, labor intensive, expensive, or make their assessment in

175 y, the techniques for ZIKV diagnosis require labor-intensive, expensive and lengthy tests using sophi

176 te to quantify 5-HT(2C) receptor editing are labor-intensive, expensive and provide limited informati

177 ancer development, these models are much too labor-intensive, expensive, and slow to perform the exte

178 ssay can be a viable alternative to the more labor-intensive filtration and centrifugation methods.

179 t methods of detection are too expensive and labor-intensive for routine detection of these organisms

180 Although the measurements are labor intensive, FRET in liposomes can be measured accur

181 tissue surface coverage than destructive and labor-intensive frozen section analysis techniques.

182 easurements are necessary but also extremely labor intensive if manual flux chamber based methods are

183 These tasks may be labor intensive if performed manually.

184 arsing problems that have made such analyses labor-intensive in the past.

185 This approach bypasses labor-intensive in vitro mutagenesis and samples a large

186 ncerns related to integration included being labor intensive, inadequate staff to implement, inadequa

187 However, these methods are labor intensive, incompatible with most other histochemi

188 However, SELEX is a lengthy, labor-intensive, iterative process requiring multiple ro

189 and abiotic stresses are time-consuming and labor-intensive limiting the ability to dissect the gene

190 The surveillance of SSIs is labor-intensive limiting the generalizability and scalab

191 roach for functional studies but it is often labor intensive, limiting systematic gene surveys to the

192 ges or hemilineages unambiguously other than labor-intensive lineage-tracing methods.

193 phenotypic screening using rodent models is labor intensive, low-throughput, and very expensive.

194 l cultivation approaches in microbiology are labor-intensive, low-throughput, and yield biased sampli

195 id, accurate and reproducible alternative to labor intensive manual gating strategies.

196 elated diseases, which extremely reduces the labor-intensive manual annotation.

197 luating cardiomyocyte function that requires labor-intensive manual effort.

198 s for surgery to overcome time-consuming and labor-intensive manual processes.

199 testing can often be performed only by using labor-intensive, manual dilution methods and lies outsid

200 isotherm linearity, thereby enabling a less labor intensive means to generate the extensive data set

201 is as accurate and effective as traditional labor-intensive measures of flowering time, height, biom

202 onditional knockout mice are generated using labor-intensive methods of homologous recombination in e

203 Other methods of detection rely on labor-intensive, microscopy-based techniques.

204 ironmental isolates prior to conducting more labor-intensive molecular typing methods.

205 to assessing digitized images but remains a labor-intensive, monotonous, and time-consuming procedur

206 apping procedure requires time-consuming and labor-intensive offline sample preparation steps.

207 ing DNA repair capacity (DRC) are relatively labor intensive, often indirect, and usually limited to

208 for the detection of IGH translocations are labor intensive, often require viable cells, and are bia

209 y complex and often inefficient devices, and labor-intensive operation.

210 mpatibility for automated data analysis, and labor-intensive operations.

211 ngle sample are typically time-consuming and labor intensive or require large sample sizes to split f

212 rus per cell culture dish than the much more labor-intensive organotypic culture.

213 e determination typically involves time- and labor-intensive PCR-based amplification and cloning meth

214 physical genome maps obviating the need for labor-intensive physical genome mapping.

215 Such a delayed and labor-intensive procedure creates a barrier to automatio

216 This is a labor-intensive procedure, prone to human error and subj

217 sitivity, complexity, and time-consuming and labor-intensive procedure.

218 e free of tumor cells-a costly and time- and labor-intensive procedure.

219 ologID, a Web application that automates the labor-intensive procedures of gene orthology determinati

220 o mention easy-to-use detection to eliminate labor-intensive procedures.

221 in mass spectrometry data analysis and is a labor intensive process for many proteomics laboratories

222 This labor-intensive process could be made easier by automati

223 -specific labeling of nonnative cysteines, a labor-intensive process occasionally resulting in dimini

224 neers face significant challenges during the labor-intensive process of designing microfluidic device

225 knowledge bases manually compiled through a labor-intensive process or automatically derived using s

226 t useful for the desired analysis; this is a labor-intensive process that is often impossible or unfe

227 These high-throughput but labor-intensive projects serve as an ideal way to introd

228 athology and immunohistochemistry, which are labor-intensive, prone to sampling bias and technical va

229 omprehensive assessment of methylated sites, labor-intensive protocols, and/or the need for expensive

230 ained by limitations of techniques that were labor-intensive, provided coarse levels of resolution, o

231 directly in the flask without dangerous and labor-intensive purification operations or exposure of t

232 ghput assays instead of using the costly and labor-intensive radioactive ligands.

233 mazonian land use, which did not necessitate labor-intensive rainforest clearance for earthwork const

234 Pathologic diagnosis requires labor-intensive reading of a large number of tissue slid

235 measuring regional pollen concentrations are labor-intensive, requiring special equipment and manual

236 sequences, but it currently is hampered by a labor-intensive sample preparation process designed to i

237 of large populations of nematodes, requiring labor-intensive sample preparation that considerably lim

238 or most of the genes previously obtained by labor-intensive screening for pattern-defective mutants.

239 We conclude that, despite the labor-intensive search for existing guidelines, a de nov

240 Highly labor-intensive serial sectioning studies have demonstra

241 agreement with population sequencing and the labor-intensive single-genome sequencing method.

242 n reported due to the requirement for highly labor intensive, slow, and low efficiency laboratory exp

243 ent to manual analysis, as being subjective, labor-intensive, slow, and often incapable of showing th

244 n invented to eliminate a time-consuming and labor-intensive step in preparation of in vivo study sam

245 ormed on cell lysates, which circumvents the labor-intensive step of DNA extraction, and rely on the

246 a liquid handling platform, to automate this labor-intensive step.

247 and infectivity can circumvent the time and labor-intensive steps associated with viral antigen-base

248 transduction, is one of the most costly and labor-intensive steps in the production of cellular ther

249 enome assembly--which are time-consuming and labor-intensive steps.

250 e and limited by multiple time-consuming and labor-intensive steps.

251 uptake and depuration rate constants require labor intensive studies with large numbers of organisms.

252 tability in dust before designing costly and labor-intensive studies of allergen exposure and health

253 trast to traditional methods which are often labor-intensive, subjective to bias and do not allow fur

254 of outbreaks and nosocomial transmission are labor-intensive, subjective, or insufficiently discrimin

255 are requires multidisciplinary coordination, labor-intensive support for critically ill patients, and

256 these ecosystem-level changes often requires labor-intensive surveys that are unable to detect rapid

257 es, but their preparation can be hampered by labor-intensive synthesis of required starting materials

258 However, culture is labor-intensive, takes several days to weeks for growth,

259 nsequences of individual mutations remains a labor-intensive task.

260 f alpha-amino acids as an alternative to the labor-intensive technique of chromatography.

261 Unfortunately, IP is a labor-intensive technique, is difficult to perform in pa

262 sported to a central laboratory for slow and labor intensive tests.

263 This approach is rapid and less labor intensive than are traditional methods, without di

264 or platform is significantly faster and less labor intensive than commonly available technologies, ma

265 the DiversiLab system was considerably less labor intensive than PFGE and provided results in less t

266 ventilator-associated pneumonia, it is more labor intensive than the calibrated loop technique.

267 fold transplantation is more complicated and labor-intensive than cell suspensions, it affords de nov

268 d is accurate, cheaper, more rapid, and less labor-intensive than DNA sequencing.

269 It is less labor-intensive than previously described assays and is

270 This method is less labor-intensive than those that require isolation and am

271 hydrolysis protocol which is cumbersome and labor intensive, this new protocol is ideal for high-thr

272 ay is sensitive and accurate, it is slow and labor-intensive; thus, it precludes the simultaneous scr

273 such screens, the current procedure remains labor intensive, time consuming, and costly.

274 the detection of bed bugs often necessitates labor-intensive, time-consuming and invasive visual insp

275 ridization (FISH) and have consequently been labor-intensive, time-consuming and restricted to the lo

276 However, it is a labor-intensive, time-consuming hybridization process an

277 Surgery is a labor-intensive, time-consuming profession.

278 The process is labor-intensive, time-consuming, and expensive.

279 ing test because it is widely perceived as a labor-intensive, time-consuming, and technically demandi

280 g such pairs of mammalian cells, however, is labor-intensive, time-consuming, and, in some cell types

281 However, existing techniques are often labor-intensive, time-consuming, irreproducible, require

282 use high-magnification DFM images, which are labor intensive to acquire and subject to operator bias.

283 been impeded by methods that are either too labor intensive to allow large-scale studies or not suff

284 It can be quite labor intensive to curate, import, and analyze the data

285 echnology is too costly, time consuming, and labor intensive to meet this ongoing demand.

286 sis (FSA), are destructive and too time- and labor-intensive to be practical or economical.

287 ption to BC because it is time-consuming and labor-intensive to obtain isotherms on soot and other BC

288 throughput assays, they can be inconsistent, labor-intensive to obtain, and can miss in vivo effects.

289 niques that are much more time-consuming and labor-intensive to perform.

290 in vivo have typically relied on costly and labor-intensive transgenic strategies in mice.

291 to detect these modifications are expensive, labor-intensive, unfeasible in some contexts and leave a

292 Such analyses are time-consuming and labor-intensive using conventional means.

293 es in the cell culture is time-consuming and labor-intensive, usually involving a purification step t

294 site-year combinations mimicking common, but labor-intensive, water-sampling regimes (e.g., time-inte

295 These methods are labor-intensive when measuring methane emissions from a

296 l VI assessments are often time-, cost-, and labor-intensive; whereas traditional subsurface methods

297 diagnostic method can be time consuming and labor intensive, which is not practical for on-site diag

298 ional methods determining TPC are costly and labor-intensive, which are not practical for wheat breed

299 op molecular diagnosis is time-consuming and labor-intensive, which limits the treatment efficiency e

300 Some of these tests are labor-intensive, while others require little labor, and