ライフサイエンスコーパス: laboratory mice

1 osed to BD and its potent carcinogenicity in laboratory mice.

2 VP establishes acute and latent infection in laboratory mice.

3 n minimize a widespread source of anxiety in laboratory mice.

4 pects of severe COVID-19 disease in standard laboratory mice.

5 pansions found in old specific pathogen-free laboratory mice.

6 to establish virus latency in the spleens of laboratory mice.

7 ructure of genetic variation among classical laboratory mice.

8 ng-term protective immunity in a majority of laboratory mice.

9 erences in the general learning abilities of laboratory mice.

10 igen of the HGE agent and was infectious for laboratory mice.

11 havior-->gene) approaches in both humans and laboratory mice.

12 responsible for the xenotropism of X-MLVs in laboratory mice.

13 d strain]), were studied in cell culture and laboratory mice.

14 ose previously identified using conventional laboratory mice.

15 activity, as well as the ability to colonize laboratory mice.

16 well as xenotropic MLV, which do not infect laboratory mice.

17 es between control of sleep in humans and in laboratory mice.

18 RNA virus is thus maintained indefinitely in laboratory mice.

19 al inoculation of the spleen homogenate into laboratory mice.

20 gulatory effect of TNF on T cells in healthy laboratory mice.

21 etween M. castaneus and MCF MuLV-susceptible laboratory mice.

22 a challenge in modeling human diseases using laboratory mice.

23 cking in standard preclinical models such as laboratory mice.

24 patocytes across nine widely used strains of laboratory mice.

25 ence and potential triggers of aggression in laboratory mice.

26 changes in muscle force generation in active laboratory mice.

27 r natural rodent pathogens-are cohoused with laboratory mice.

28 e modulated by locomotion in male and female laboratory mice.

29 and 10 mg/kg) alter sleep in wild-type male laboratory mice.

30 of neuronal activity in the visual system of laboratory mice.

31 responses is difficult to model in standard laboratory mice.

32 wo mA3 alleles found among inbred strains of laboratory mice.

33 ate its detailed function, principally using laboratory mice.

34 greater stability than the gut microbiota of laboratory mice.

35 es observed in the colonic mucus of wild and laboratory mice.

36 ously adapted NrHV to prolonged infection in laboratory mice.

37 g natural gut microbiota from wildlings into laboratory mice.

38 of female social aggression and dominance in laboratory mice.

39 V has been adapted to infect immunocompetent laboratory mice.

40 t physiological parameter in many studies of laboratory mice.

41 ighly activated myeloid cells not present in laboratory mice.

42 al inflammation were not observed in Jackson Laboratory mice.

43 populations (i.e., the aged) using standard laboratory mice.

44 aced mating paradigm, in female but not male laboratory mice.

45 at establishes acute and latent infection in laboratory mice.

46 els after acute injury in several strains of laboratory mice.

47 els is widely used to initiate thrombosis in laboratory mice.

48 vation compared with artificially maintained laboratory mice.

49 (-) mice, which include commonly used inbred laboratory mice.

50 mals except most of the classical strains of laboratory mice.

51 at establishes acute and latent infection in laboratory mice.

52 ria parasite Plasmodium chabaudi evolving in laboratory mice.

53 t a mean r(2) value of 0.98 in 2,073 outbred laboratory mice (0.15x sequencing coverage).

54 ne the rodent malaria Plasmodium chabaudi in laboratory mice, a parasite-host system in which virulen

55 re acquired by the wild mouse progenitors of laboratory mice about 1 million years ago.

56 ns that are inherited as Mendelian traits in laboratory mice affect susceptibility to spontaneous TGC

57 quenced erp loci of bacteria reisolated from laboratory mice after 1 year of infection and found them

58 se microbial experience, and were induced in laboratory mice after co-housing with pet store mice, su

59 f the range of germline mutations induced in laboratory mice after parental exposure to ionizing radi

60 Laboratory mice and 2 species of bats were exposed, thro

61 ects both cutaneous and mucosal epithelia of laboratory mice and can be used to model high-risk human

62 he growing evidence, obtained primarily from laboratory mice and humans, that the ability to sense li

63 ygenic models in multiple species, including laboratory mice and humans.

64 Immune responses differ between laboratory mice and humans.

65 hin populations of wild and laboratory fish, laboratory mice and humans.

66 ort genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more varia

67 s) are found in the common inbred strains of laboratory mice and in the house mouse subspecies ofMus

68 However, studies on laboratory mice and nonhuman primates revealed ambiguous

69 onstrate that the low recombination rates in laboratory mice and rats reflect a more general reductio

70 esembles WS2 than comparable Mitf alleles in laboratory mice and rats, which are expressed as purely

71 y the onset of age-associated pathologies in laboratory mice and rats.

72 lived species, from unicellular organisms to laboratory mice and rats.

73 bits parental behaviors and social memory in laboratory mice and rats.

74 We utilize laboratory mice and their innate inter-individual differ

75 te the study of complex genetic traits using laboratory mice and, if implemented as a "gene drive," t

76 ly shown to contribute to Fv1 restriction in laboratory mice, and 3 codons in a 10-codon segment over

77 e seen in blood from pet store-raised versus laboratory mice, and adult versus cord blood in humans.

78 N) virus causes fatal meningoencephalitis in laboratory mice, and gammadelta T cells are involved in

79 an ACE2 (hACE2), two strains of conventional laboratory mice, and Syrian hamsters.

80 1 resistance alleles have been identified in laboratory mice, and they target virus capsid genes to p

81 ites are common in humans, but are absent in laboratory mice, and thus represent potential contributo

82 eri and the spirochetemia of B. hispanica in laboratory mice, apolipoprotein E (apoE)-deficient and l

83 veral methods to model human Ph+ leukemia in laboratory mice are available, including propagation of

84 Together, our results demonstrate that laboratory mice are capable of exhibiting dynamic and ac

85 Dogs and laboratory mice are commonly trained to perform complex

86 t female- and male-directed mounting in male laboratory mice are distinguishable by the presence or a

87 The alpha1-protease inhibitor proteins of laboratory mice are homologous in sequence and function

88 indicate that diverse learning abilities of laboratory mice are influenced by a common source of var

89 e data suggest that the cold stress to which laboratory mice are ubiquitously subjected profoundly af

90 nt research that calls into question the way laboratory mice are used to address questions in basic s

91 Although laboratory mice are usually highly susceptible to Yersin

92 Laboratory mice are valuable models of HGE agent infecti

93 Using rodent malaria in laboratory mice as a model system and the statistical fr

94 comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological m

95 family are not as numerous in the genomes of laboratory mice as are members of the older A and F subf

96 of mammalian physiology have been made using laboratory mice as research models.

97 ed analysis of risk factors for barbering in laboratory mice based on point prevalence of hair loss i

98 Laboratory mice bearing inactivating mutations in the ge

99 ne leukemia viruses cannot infect cells from laboratory mice because of the lack of a functional cell

100 row phenotypes not normally observed in aged laboratory mice but commonly seen in elderly humans.

101 Numerous studies in laboratory mice, but very few in natural influenza A vir

102 signal transduction and for colonization of laboratory mice by C. rodentium.

103 The isolate was pathogenic for laboratory mice by the intracerebral and intramuscular r

104 1 hybrid EpiSCs derived from crosses between laboratory mice (C57BL/6J) and four wild-derived inbred

105 ice (genus Peromyscus) and compare them with laboratory mice (C57BL6/J strain) and free-living, wild

106 Laboratory mice carry mouse leukemia viruses (MLVs) of t

107 ypic analysis of immunological parameters in laboratory mice carrying susceptibility genes implicated

108 fferentiation are derived from pathogen-free laboratory mice challenged with a single pathogen or vac

109 sters identified in humans, chimpanzees, and laboratory mice, characterized by differences in Bactero

110 Laboratory mice cohoused for 2 weeks had impaired ILC2 r

111 Laboratory mice comprise an expeditious model for precli

112 estoring physiological microbial exposure in laboratory mice could provide a relevant tool for modell

113 Laboratory mice develop populations of circulating memor

114 The laboratory mice developed clinical signs and splenomegal

115 In the laboratory, mice dig vigorously in deep bedding such as

116 t may reside in the challenges, which normal laboratory mice do not encounter.

117 However, there is growing concern that laboratory mice do not reflect relevant aspects of the h

118 of the hypothalamus of adult male and female laboratory mice does not merely trigger awakening from s

119 MA10) with the potential to infect wild-type laboratory mice, driving high levels of viral replicatio

120 ion define three MLV host range subgroups in laboratory mice: ecotropic, polytropic, and xenotropic M

121 ing the genetics underlying domestication in laboratory mice, especially in the widely used classical

122 e report that the retinas of some strains of laboratory mice exhibit robust circadian rhythms of mela

123 oxyadenosine (1,N(6)-HMHP-dA), in tissues of laboratory mice exposed to 6.25-625 ppm BD.

124 arameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune

125 odentium espB mutant also failed to colonize laboratory mice following experimental inoculation.

126 The standard method used to pick up laboratory mice for general husbandry and experimental p

127 e experiment using 579 genetically identical laboratory mice from a single animal facility, designed

128 In recent years in silico analysis of common laboratory mice has been introduced and subsequently app

129 iota from wild mice to genetically tractable laboratory mice has been shown to enhance modeling of hu

130 Research using laboratory mice has led to fundamental insights into the

131 s analysis of the recombination landscape in laboratory mice has revealed that the different subspeci

132 c choriomeningitis virus (LCMV) infection of laboratory mice has served as a powerful model to unders

133 Laboratory mice have been the stalwart of therapeutic an

134 Studies on laboratory mice have demonstrated that host genetics can

135 Laboratory mice have longer telomeres relative to humans

136 Genetic crosses of laboratory mice have provided extensive information abou

137 Laboratory mice have provided invaluable insight into ma

138 Here, we show that laboratory mice have retained gut bacterial lineages tha

139 lity and inconsistent fungal colonization of laboratory mice hinders the study of the evolutionary an

140 Conventional laboratory mice housed under specific pathogen-free (SPF

141 Laboratory mice housed under specific pathogen-free (SPF

142 Standard housing temperature for laboratory mice in research facilities is mandated to be

143 -thermoneutral housing temperatures used for laboratory mice in research institutes is sufficient to

144 s, including domesticated animals and inbred laboratory mice (in SeSAMe version 1.16.0+).

145 permissive Xpr1(sxv) allele in 7 strains of laboratory mice, including a Bxv1-positive strain, F/St,

146 p. nov., which was isolated from colonies of laboratory mice independently by two laboratories.

147 artially attributed to microbial exposure as laboratory mice infected with pathogens exhibit immune p

148 se results suggest that unlike pathogen-free laboratory mice, infection or immunization of latently i

149 Laboratory mice initially show alternating approach and

150 immune system maturation by releasing inbred laboratory mice into an outdoor enclosure.

151 rewilding, the controlled release of inbred laboratory mice into an outdoor enclosure.

152 Aggression in group-housed laboratory mice is a serious animal welfare concern.

153 virus 68 (MHV68, MuHV-4, yHV68) infection of laboratory mice is a well-established pathogenesis syste

154 ptor for entry, and the unique resistance of laboratory mice is due to two mutations in different put

155 in both radiation safety and the handling of laboratory mice is required for the successful execution

156 y is based on secretions derived from inbred laboratory mice, it remains uncertain whether such stimu

157 Standard Mus musculus laboratory mice lack a functional XPR1 receptor for XMRV

158 Laboratory mice--like newborn, but not adult, humans--la

159 Laboratory mice live in abnormally hygienic specific pat

160 In humans and certain strains of laboratory mice, male tissue is recognized as nonself an

161 , if not most, TCE in specific pathogen-free laboratory mice may be Ag-independent.

162 Laboratory mice (Mus musculus domesticus) harbor gut bac

163 In laboratory mice (Mus musculus domesticus), alpha(1)-PI o

164 Laboratory mice (Mus musculus) are typically housed in s

165 Laboratory mice (Mus musculus) communicate a variety of

166 Systems genetics in laboratory mice (Mus musculus) enables data-driven disco

167 Laboratory mice (Mus musculus) have long telomeres, alth

168 The papillomavirus, MmuPV1, which infects laboratory mice (Mus musculus), can cause infections in

169 rrier from deer (Odocoileus spp) to standard laboratory mice (Mus musculus).

170 are day-active murid rodents, and nocturnal laboratory mice (Mus musculus).

171 in Western Europe, which is unable to infect laboratory mice (Mus sp.) without the aid of powerful im

172 ated wound-induced hair neogenesis (WIHN) in laboratory mice (Mus), the regeneration is limited to th

173 -type Mx1 gene (Mx1+/+) differ from standard laboratory mice (Mx1-/-) in being highly resistant to in

174 Here, we show that genetically similar laboratory mice obtained from four different commercial

175 We therefore tracked behavior of rewilded laboratory mice of three inbred strains in outdoor enclo

176 ety of cell lines and is also able to infect laboratory mice, offering an ideal model with which to s

177 ablish acute and persistent infection within laboratory mice offers a unique opportunity to investiga

178 MOLF/EiJ mice, which diverged from classical laboratory mice over a million years ago.

179 art and was transferred to and maintained in laboratory mice over several generations.

180 SARS-CoV-2 cannot infect wild-type laboratory mice owing to inefficient interactions betwee

181 tanding of immunology was largely defined in laboratory mice, partly because they are inbred and gene

182 Wildlings, but not conventional laboratory mice, phenocopied human immune responses in t

183 Laboratory mice provide a ready source of diverse, high-

184 Its adaptation to robust infection also in laboratory mice provides access to a broader set of mous

185 es have acquired novel mutational burdens in laboratory mice, providing an evolutionary rationale for

186 Laboratory mice reconstituted with natural microbiota ex

187 e function, but how well immune responses of laboratory mice reflect those of free-living animals is

188 ckcrossing of wild mice with knockout mutant laboratory mice retrieves behavioural traits exhibited e

189 metaanalysis of data from 54 experiments on laboratory mice reveals that basic ecological rules gove

190 Male laboratory mice show a mating-induced suppression of inf

191 , our study shows that the strain and sex of laboratory mice significantly affect the different indic

192 All inbred strains and outbred stocks of laboratory mice studied to date have been found to be su

193 ur data from wild mice and experiments using laboratory mice suggest estrogen signalling associates w

194 in hamsters and the conventional strains of laboratory mice tested, increases in lung infection were

195 In laboratory mice, TGCTs arise from primordial germ cells

196 We further find that selection is weaker in laboratory mice than in humans and it does not affect th

197 of superficial secondary lymphoid organs in laboratory mice that are earlier than expected and are c

198 cular, our work focuses on images of wounded laboratory mice that are used widely for translationally

199 imulated a search for IRG alleles unknown in laboratory mice that might confer resistance to virulent

200 of intense study of coat color mutations in laboratory mice, thereby creating an impressive list of

201 N) virus causes fatal meningoencephalitis in laboratory mice, thereby partially mimicking human disea

202 The 12 X-MLV ERVs predate the origins of laboratory mice; they were all traced to Japanese wild m

203 tion, reconstituting microbial experience in laboratory mice through co-housing may better inform pre

204 Our findings indicate that exposing laboratory mice to a more natural environment enhances B

205 g et al. (2020) and Lin et al. (2020) expose laboratory mice to a natural environment and use immune

206 Exposure of laboratory mice to carbon nanotubes mimics exposure to a

207 generated using specific pathogen-free (SPF) laboratory mice to humans.

208 ed to be a major cause for the resistance of laboratory mice to JUNV infection.

209 te the prospects for using dense SNP maps in laboratory mice to refine previous QTL regions and ident

210 s measured in 1812 genetically heterogeneous laboratory mice to study IGE arising between same-sex, a

211 at captures 90% of the known variation among laboratory mice, to identify the genetic loci controllin

212 alize the environmental experience of inbred laboratory mice-to take them where the wild things are (

213 ed because robust colitis is not observed in laboratory mice treated with checkpoint inhibitors.

214 ise quantitation of bis-N7G-BD in tissues of laboratory mice treated with low ppm and subppm concentr

215 In laboratory mice, unmated males and females display infan

216 LCMV-MN), which was naturally transmitted to laboratory mice upon cohousing with pet shop mice and sh

217 grade fetal calf serum as well as serum from laboratory mice using HPLC and MS identified the presenc

218 Because laboratory mice vary widely in their proviral contents a

219 r, B, and T cells, which was transferable to laboratory mice via co-housing.

220 A yeast causing widespread infection of laboratory mice was identified from 26S rRNA gene sequen

221 ty of Bb(DeltaA66)-infected nymphs to infect laboratory mice was significantly impaired compared to t

222 However, laboratory mice we use for most biomedical studies are b

223 Using laboratory mice, we artificially selected for high maxim

224 span 90% of the common genetic diversity of laboratory mice, we found that high host mortality was a

225 tivation of the ribosomal protein S6 gene in laboratory mice, we found that reduced ribosomal protein

226 Applying EDGE to laboratory mice, we show that a loss-of-function mutatio

227 dy, we used a "dirty" mouse model, where SPF laboratory mice were cohoused (CoH) with pet store mice

228 Transmission studies in laboratory mice were negative.

229 Barbering is a common abnormal behavior in laboratory mice, where mice pluck their own fur and/or t

230 types are found in the classical strains of laboratory mice, which are genetic mosaics of 3 wild mou

231 single nucleotide polymorphisms (SNPs) from laboratory mice, which are largely genetic hybrids betwe

232 This effect was not observed in Jackson Laboratory mice, which are not colonized with SFB.

233 elf-limiting hepatitis in typical strains of laboratory mice, which resolves in 2 weeks.

234 Laboratory mice, while paramount for understanding basic

235 tis virus (VEEV) is highly virulent in adult laboratory mice, while Sindbis virus (SINV) is avirulent

236 Hence, compared with laboratory mice, wild-derived mutant mice constitute an

237 Infection of laboratory mice with C. rodentium provides a useful in-v

238 Mutant laboratory mice with distinctive hair phenotypes are use

239 Therefore, exposing laboratory mice with genetic mutations to a natural envi

240 To test this, we sequentially infected laboratory mice with herpesviruses, influenza, and an in

241 ablish high-titer hepatotropic infections in laboratory mice with immunological features resembling t

242 the feasibility studies and actual tests on laboratory mice with inoculated hepatocellular carcinoma

243 Laboratory mice with over half a megabase of DNA upstrea

244 We co-housed laboratory mice with pet-store mice, which have varied m

245 Infection of laboratory mice with purified LCMV-MN resulted in viral

246 Infection of different strains of laboratory mice with the agent of Lyme disease, Borrelia

247 Finally, by cohousing our laboratory mice with the bedding of pet store rats, we i

248 Given the difficulty of infecting laboratory mice with these diarrhea-causing pathogens, a

249 ding an evolutionary rationale for restoring laboratory mice with wild gut bacterial strain diversity