ライフサイエンスコーパス: laborious

1 studying centromere genomics in biology are laborious.

2 methods is becoming increasingly complex and laborious.

3 but functional testing of identified VHHs is laborious.

4 ulture methods, which are time-consuming and laborious.

5 lysts usually involves multiple steps and is laborious.

6 DNA extraction using conventional methods is laborious.

7 ens has historically been time consuming and laborious.

8 rocesses, but studying them is difficult and laborious.

9 diagnosis in patients with PIDs complex and laborious.

10 res are available, mostly time-consuming and laborious.

11 l regulators of gene expression has remained laborious.

12 toring of molecule release are expensive and laborious.

13 which meiotic mapping is significantly more laborious.

14 f data provided makes analysis difficult and laborious.

15 zyme-linked immunosorbent assay (ELISA), are laborious.

16 r for a given application is challenging and laborious.

17 , the process of identifying markers remains laborious.

18 ide mammalian screens are both expensive and laborious.

19 Validating such reconstructions is extremely laborious.

20 biology, strain engineering remains slow and laborious.

21 s vinifera L.) genotypes is conventionally a laborious activity that must be carried out by specializ

22 The state-of-the-art methods required laborious adjustments of parameter values to achieve the

23 e without the need for sample preparation or laborious analytical methods.

24 Surgical outcome abstraction remains laborious and a barrier to the sustainment of quality im

25 gies is becoming more effective, it is still laborious and carries substantial risk of adverse events

26 dies; however, the labeling processes can be laborious and challenging for use in non-transfectable c

27 he huge amount of papers available remains a laborious and challenging work.

28 leveraged automation to ease the burden of a laborious and complicated sample pretreatment and extrac

29 me data source as prediction data is usually laborious and computationally intensive.

30 lse positives is reported, which can lead to laborious and costly attempts to provide biological vali

31 tterns of TF binding, but typically requires laborious and costly experiments for each TF-cell-type (

32 directed hPSC differentiation protocols are laborious and costly.

33 ccording to regulatory testing guidelines is laborious and costly.

34 x matched to prediction samples which can be laborious and costly.

35 y putative reagents is often time-intensive, laborious and costly.

36 Genotyping mice by DNA based methods is both laborious and costly.

37 rimetric assays for HIV detection tend to be laborious and costly.

38 greatly reducing time spent on an otherwise laborious and demanding task.

39 etween a plant and its aerial environment is laborious and destructive with current techniques, makin

40 ing phenotypic measurements of resistance is laborious and error-prone.

41 good agreement with those determined by more laborious and expensive conventional methods.

42 This process is laborious and expensive for both the computational and l

43 tal or ex vivo imaging approaches, which are laborious and expensive in vertebrate models.

44 olecules, but the standard catalysts require laborious and expensive preparations.

45 ll molecule on the expansion of HSC/HPC is a laborious and expensive process.

46 fraction of phospholipids, normally involves laborious and expensive protocols.

47 ts, offering an efficient alternative to the laborious and expensive traditional methods.

48 Conventional serotyping methods are laborious and expensive.

49 with many disulfide bridges has proven to be laborious and general methods are lacking.

50 ods to measure its activity are indirect and laborious and have low sensitivity.

51 ophila, this powerful technique has remained laborious and hence seldom implemented.

52 ion mapping of CGRs has traditionally been a laborious and highly skilled process.

53 Yet, producing these substrates remains laborious and inefficient, particularly when using the t

54 has largely relied on methods that were both laborious and inefficient.

55 tical transparency have been key advantages, laborious and invasive procedures are required for elect

56 he identification of these regulators can be laborious and is usually carried out one factor at a tim

57 phospholipase C treatment, thereby avoiding laborious and long-lasting sample purification.

58 However, the laborious and low-throughput methods of current yeast re

59 Yet it remains a laborious and low-throughput technique, making it largel

60 verall process of aptamer generation remains laborious and low-throughput.

61 able for adaptation; however, such review is laborious and may not always uncover useful guidelines.

62 s conventional methods for its diagnosis are laborious and not easily reproducible.

63 However, OFCs are laborious and not without risk; thus, a test that could

64 and techniques are time-consuming, manually laborious and often expensive due to the excessive consu

65 ple preparation preceding dNAAT is generally laborious and performed manually, thus creating the need

66 on from experimental micrographs thus can be laborious and presents a major practical bottleneck in c

67 Large-scale germination experiments are laborious and prone to observer errors, leading to the n

68 or removing these fluctuations, which can be laborious and prone to subjective bias.

69 entify novel vaccine candidates are commonly laborious and protracted.

70 However, they are laborious and require skilled personnel.

71 lated tuber-bearing potato relatives, but is laborious and slow.

72 Using current methods, however, it is laborious and sometimes difficult to generate antibodies

73 insects in the laboratory but this can be a laborious and sometimes fruitless process.

74 while effective for sighted animals, can be laborious and stressful in animals with impaired vision,

75 stoStitcher is still manual and hence can be laborious and subjective, especially when doing large co

76 an be hand-coded, such a process tends to be laborious and subjective.

77 ature engineering is usually time consuming, laborious and subjective.

78 ll culture systems; however, these tests are laborious and suffer decreased sensitivity for advanced-

79 hod is highly discriminatory; however, it is laborious and technically demanding, and data exchange r

80 o measure cooperativity parameters have been laborious and therefore limited to studying only a few s

81 uring WUE(i) by gas exchange measurements is laborious and time consuming and may not reflect an inte

82 This is a laborious and time consuming process.

83 folded subproteome and, moreover, are rather laborious and time consuming.

84 It can substitute the laborious and time-consuming analytical evaluation.

85 yme-linked immunosorbent assays (ELISA), are laborious and time-consuming and lack sensitivity.

86 tools for this purpose, these protocols are laborious and time-consuming and typically require the a

87 eria in food products as alternatives to the laborious and time-consuming culture procedures.

88 gnificant because, in contrast to the common laborious and time-consuming heterogeneous binding appro

89 l performed in multiwell plates and requires laborious and time-consuming manual manipulation of spec

90 Laborious and time-consuming manual tracing of kidneys a

91 the field still needs to rely on a 50-y-old laborious and time-consuming method to assess the lifesp

92 of key genes for mycotoxin biosynthesis is a laborious and time-consuming procedure.

93 operational costs, low throughput screening, laborious and time-consuming procedures, and ethical con

94 However, this is a laborious and time-consuming process, and mass spectrome

95 ostructures and functional devices remains a laborious and time-consuming process.

96 ernative to established methods that require laborious and time-consuming sample treatments and expen

97 Raman spectroscopy) is only possible through laborious and time-consuming statistical analysis, which

98 However, these methods are associated with laborious and time-consuming steps, such as the generati

99 ors, because these adducts currently require laborious and time-consuming syntheses and purification.

100 Conventional UDS and RRS assays are laborious and time-consuming, as they measure the incorp

101 repetitive wash steps with a pipet that are laborious and time-consuming, making the procedure ineff

102 lation/density, procedure that is considered laborious and time-consuming, methods based on chromatog

103 electrophoresis-based detection procedure is laborious and time-consuming, often requiring visual ins

104 This approach was successful but highly laborious and time-consuming, precluding general applica

105 ess, the establishment of mutant ES cells is laborious and time-consuming, restricting the study of t

106 s, such as patch-clamp electrophysiology, is laborious and time-consuming.

107 sition frequently use toxic solvents and are laborious and time-consuming.

108 ion and/or other molecular tests are usually laborious and time-consuming.

109 with restriction enzyme digestions, which is laborious and time-consuming.

110 ic Ab should be detected separately which is laborious and time-consuming.

111 Many methods employed are laborious and time-consuming; recent advances, translate

112 ucts, and conventional PCR-based methods are laborious and time-intensive.

113 yet current detection techniques tend to be laborious and/or expensive.

114 protocols for genome-wide TSS profiling are laborious and/or expensive.

115 husbandry records is both time intensive and laborious, and a standardized way to manage and track th

116 Since immunoblots are time-consuming, laborious, and challenging to interpret, MTTT provides a

117 across these large datasets can be nuanced, laborious, and difficult for new practitioners.

118 tively deuterated PUFAs require rather long, laborious, and expensive syntheses.

119 Serology is cross-reactive, laborious, and frequently difficult to interpret, and se

120 However, these genetic methods are laborious, and limited for quantitative study.

121 emains extremely slow because of the manual, laborious, and time-consuming histological procedures.

122 f animals with phosphopeptides is expensive, laborious, and time-consuming.

123 ore may aid the replacement of expensive and laborious animal models.

124 raphy prefractionation, a time-consuming and laborious approach.

125 These studies often involve laborious assays of multiple individual variants that ar

126 egulators is challenging and often relies on laborious assays or indirect reporter read-outs.

127 e NMR experiments and easier to compile than laborious assignments of non-solvent-exchangeable proton

128 A-origami structure through AGE is typically laborious because of the post-electrophoresis extraction

129 red for new or altered function, however, is laborious because the engineering must be replicated for

130 overy of common light chains, or complex and laborious biochemical processing.

131 ovement pattern, serial training is not only laborious but can also be ineffective.

132 ocesses that are not only time-consuming and laborious but can also result in significant sample loss

133 apped bead, without the need of embarking on laborious calculations.

134 rgeting large-insert clones using costly and laborious capillary-based sequencing approaches.

135 ially induced genetic variations and require laborious characterization of the progenies of multiple

136 abels, which involves rather complicated and laborious chemical synthesis.

137 e previously required, but the procedure was laborious, complex, and technically challenging.

138 essential proteins are usually expensive and laborious, computational methods, which utilize biologic

139 ts undergoing potent gene silencing requires laborious design, visual screening, and physical separat

140 cal interpretation of novel findings without laborious downstream analyses.

141 Using this feature, the conventional and laborious dry-down step prior to reaction is circumvente

142 ntly, mRNA-based reprogramming is relatively laborious due to the need to transfect daily for ~2 week

143 ent (IRE) without the need for polishing and laborious edge preparation.

144 As a result, no laborious enrichment techniques are needed.

145 CP, also called "microperimetry") constitute laborious examinations.

146 Laboratory methods can be laborious, expensive and require specific technical expe

147 ilable tools to measure these parameters are laborious, expensive, and inefficient for handling multi

148 Current methods for diagnosing DMD are often laborious, expensive, invasive, and typically diagnose t

149 , which allows estimating the feasibility of laborious experimental assays and aids in their design.

150 limited by a dependence on haplotyping from laborious experiments or extra genome/family trio data.

151 of the sensor without need of extensive and laborious extraction processes are demonstrated in water

152 nables cell-specific transcriptomics without laborious FACS-based cell sorting or biochemical isolati

153 th minimum input data requirements, removing laborious feature extraction and data preprocessing step

154 This approach is laborious for certain applications, such as protein puri

155 a trans-blocking strategy, which requires a laborious gel separation and extraction step.

156 lian system in vivo, we sought to bypass the laborious generation of a transgenic animal by exploitin

157 y metabolic disease models still depend upon laborious germline targeting, and are further complicate

158 Although laborious hand scrubbing of reefs also reduced algal cov

159 and engineer stable, active enzymes without laborious high-throughput activity screens.

160 g immunization and 2) to minimize subsequent laborious hybridoma efforts by positive selection of Ag-

161 d robust system has the potential to replace laborious identification schemes in field environments.

162 ic craniofacial procedures mainly due to the laborious implantation requirements.

163 uch data sets can be large and data analyses laborious, improved tools are needed for data analyses a

164 nial (SSG) susceptibility of Leishmania is a laborious in vitro assay of which the result has little

165 ounding each genome edit, which necessitates laborious in vitro DNA splicing.

166 cues eliciting their activity is hindered by laborious in vitro experiments, especially when there ar

167 novo genome assemblies without the need for laborious in vivo cloning steps.

168 ods for detecting DNA rearrangements require laborious indirect assays.

169 icability in standard quality control due to laborious isolation and purification steps.

170 ntly available research tools, which involve laborious isolation, separation and characterization ste

171 tivity with metal ion binding, necessitating laborious iterative substrate optimization.

172 As such, it offers important advantages over laborious layer-by-layer methods for solar cells and pho

173 ut constructing conditional alleles is often laborious, limited by target gene structure, and at time

174 A protocol-by-protocol approach, though laborious, makes sense for both investigators and IRBs a

175 and it has been carried out in a similar and laborious manner over many decades.

176 Compared to laborious manual analysis of the MS/MS spectra, the pres

177 s generated by CIU experiments, resulting in laborious manual analysis remaining commonplace.

178 which would otherwise require extensive and laborious manual assessment.

179 with coral embryos and larvae often requires laborious manual counting and sorting of individual spec

180 of junctions of mammalian epithelia requires laborious manual measurements that are a major roadblock

181 tinuously separated from their progeny via a laborious manual microdissection procedure.

182 MS (LC-MS/MS) runs remains a challenging and laborious manual process.

183 To eliminate laborious manual processing of samples, and to minimize

184 equent verification of iPSC pluripotency are laborious, manual processes limiting the scale and repro

185 Gold standard approaches require laborious measurements of total microbial load, or absol

186 have evolved during the past few years from laborious measurements on discrete samples to continuous

187 This simple and non-laborious method can be used for elicitation of herbal p

188 tabolic products is hindered by the slow and laborious methods available for evaluating product conce

189 ization of polymer brush formation relies on laborious methods that use a quartz crystal microbalance

190 They require complex and laborious methods to locate, and many still lack methods

191 nanotechnology, over other more invasive and laborious methods, for identifying potential diagnostic

192 by sophisticated and expensive equipment and laborious methods.

193 is of similar sensitivity to existing, more laborious methods.

194 an replace, in routine analysis, complex and laborious MS methods in the study of lignin composition.

195 r heterogenous spatial distribution, and the laborious nature and low sensitivity of the current meth

196 ple size, as they were when mapping required laborious on-ground survey.

197 lent labeling of the enzyme to the antibody, laborious operating procedures, and extensive washing st

198 metals require expensive instrumentation and laborious operation, which can only be accomplished in c

199 roaches require bisulfite treatments and are laborious or costly to perform.

200 xistence of reference datasets, which may be laborious or expensive to collect.

201 f the four polymorphisms are either slow and laborious or extremely expensive.

202 can HILIC analyses have however tended to be laborious or require compromises in sensitivity.

203 lonies by PCR, due to being too lengthy, too laborious or yielding poor quality DNA and inconsistent

204 o replace the reliance on more expensive and laborious PCR assays.

205 It will make laborious PCR based technique less obligatory as it allo

206 ongation complexes using EcoRIE111Q requires laborious PCR using many different oligonucleotides for

207 recruit altered reading circuits and rely on laborious phonology-based "sounding out" strategies into

208 samples, (ii) circumventing the traditional laborious picking and functional testing of individual p

209 circuits control which behaviors has been a laborious piecemeal process, usually for one observer-de

210 Many recent techniques still involve laborious pipetting steps for spheroid manipulation such

211 rain amyloid burden in small animals require laborious post-mortem histological analysis or resource-

212 ed in real water samples without the need of laborious pre-treatment steps.

213 of phosmet in olive oil samples without any laborious pre-treatment.

214 A lengthy and laborious procedure is an additional challenge of protei

215 tions and the solid-state, circumventing the laborious procedure of identifying the experimental cond

216 Currently, analysis of HDX-MS data remains a laborious procedure, mainly due to the lack of streamlin

217 itu humanization), but such efforts involved laborious procedures and were limited in size and precis

218 ic ion channels is contrasted with existing, laborious procedures that require membrane protein extra

219 or performing AST without trained personnel, laborious procedures, or bulky instruments, thereby dece

220 ng it for subsequent analysis is currently a laborious process involving experienced health-care prof

221 s of AT are limited, however, because of the laborious process of collecting and analyzing samples.

222 way ligation followed by gel purification, a laborious process that often leads to low yield both in

223 affairs and to cut labor costs and expedite laborious processes in mining, tunneling, construction,

224 nerships, bring about revision of costly and laborious processes of licensing and regulation of new a

225 strategy we employ bypasses the traditional laborious processes to elicit gene cluster expression an

226 sue culture, involving complicated, long and laborious processes.

227 because of difficult material synthesis and laborious processing.

228 Ziehl-Neelsen is laborious, prone to human error and infection risk, with

229 it mapping using electron microscopy demands laborious proofreading or reconciliation of multiple ind

230 ving as compared to conventional LC-MS where laborious protein precipitation or other sample pretreat

231 ies require specialised bacterial strains or laborious protocols.

232 rs is usually based on libraries produced by laborious protocols.

233 roved techniques for humanizing mice without laborious purification of HSC.

234 low-yielding, requiring long reaction times, laborious purification steps and often extreme condition

235 for use of next-gen VOA as proxies for more laborious QVOA, while providing greater sensitivities an

236 The method generally involves laborious radioactive gel electrophoresis and is not con

237 However, this approach requires laborious reagent generation procedures and entails unpr

238 for HHT patients is impeded by the need for laborious, repeated phenotyping and gaps in knowledge re

239 their use in medical research is hampered by laborious reprogramming procedures that yield low number

240 reference methods of SPC in orange juice are laborious, requiring several extractions with successive

241 Traditional methods utilize harsh and laborious sample dehydration procedures, often leading t

242 ional death/viability assays usually involve laborious sample preparation and expensive equipment or

243 es) often require multiple dilution steps or laborious sample preparation prior to spectroscopic anal

244 activated dissociation, without the need for laborious sample preparation procedures.

245 pathogenic microorganism detection without a laborious sample preparation process and without the use

246 commercial formulations without the need for laborious sample preparation steps.

247 on, significant input proteome requirements, laborious sample preparation, and expensive equipment.

248 ailable but can suffer from low selectivity, laborious sample preparation, and/or the need for comple

249 paration, requiring metabolism quenching and laborious sample preparation, the objective of the study

250 ure facility emissions, without conventional laborious sample pretreatment.

251 or laboratory science, but a drawback is the laborious sample processing required before MS analysis.

252 wever, the assay's low sample throughput and laborious sample workup procedure are limiting factors t

253 scribed because their discovery required the laborious screening of patient tumour-infiltrating lymph

254 This method, however, requires the laborious selection of aptamers with high target specifi

255 ts in quantitative traits that often rely on laborious selection of rare naturally occurring mutation

256 egy for the four porphyrin species without a laborious separation process.

257 data using sequencing by synthesis remains a laborious, slow and expensive process.

258 ction of cell surface antigens obviating the laborious steps of protein purification and labeling.

259 itectured electrodes often involves multiple laborious steps that are not directly scalable to curren

260 informative of underlying pathology as more laborious subtype diagnoses.

261 ic coupling via reactive esters requiring no laborious surface pretreatment.

262 parable results, use of the cheaper and less laborious swab technique is acceptable and may be prefer

263 mplex equipment, multiple chemical reagents, laborious system calibration and procedures, and highly

264 onventional genotoxicity testing methods are laborious, take time and are expensive.

265 arallelizable approach that does not require laborious target-specific purification to generate dual-

266 partial least squares (PLS) regression, is a laborious task because (1) the number of measurements re

267 inspection of raw EEG recordings, which is a laborious task prone to inter-individual variability.

268 d literature and models is an essential, yet laborious task.

269 ficulty validating their predictions without laborious testing in 'wet' labs.

270 etabolic engineering in plants relied on the laborious testing of ad hoc modifications to achieve des

271 t was then analysed by RPLC-GC, avoiding the laborious thin layer chromatography step used in the Off

272 sent, data aggregation and visualization are laborious, time consuming, and subject to human error.

273 of identifying activated CD8(+) T cells are laborious, time-consuming and expensive due to the exten

274 apeutic drugs in biofluids typically require laborious, time-consuming, and expensive analytical work

275 n in separate production processes, which is laborious, time-consuming, and prone to variability betw

276 for disease diagnosis, involves lengthy and laborious tissue preparation.

277 lity and automation compared with common but laborious titration approaches, and greatly improves scr

278 typing techniques are too time-consuming and laborious to be carried out within the limited time cons

279 etry (MS) due to the high salt levels, it is laborious to identify the constituents of HIC peaks.

280 ut as most primers are genus-specific, it is laborious to identify unknown samples.

281 light propagation in tissue, but is somewhat laborious to implement and does not incorporate the reje

282 is a valuable protein characteristic but is laborious to improve experimentally.

283 domains or motifs, which are challenging and laborious to map by using standard biochemical approache

284 d yields liquid ternary nano-alloys that are laborious to obtain via wet-chemistry synthesis.

285 ore potent therapeutically and they are more laborious to prepare, future studies should focus on uns

286 cell antigens, which are both dangerous and laborious to produce.

287 onal Ab formats (IgG, IgM) are expensive and laborious to produce; however, the introduction of new r

288 l and pathological processes; however, it is laborious to study sialylated glycoproteins due to the l

289 tablishing epigenetic landscape without more laborious transcriptional regulations.

290 t-wide significance, triggering a process of laborious triaging of genomic-association-study results.

291 nd commonly employed, but generally requires laborious trial-and-error approaches.

292 lly materials discovery has been driven by a laborious trial-and-error process, knowledge-driven mate

293 milar to those for the conventional but more laborious tube-based extraction.

294 Could (or should) this be the laborious, uncertain, and high-risk trajectory of disrup

295 nt of the property of interest, oftentimes a laborious undertaking.

296 enomic loci in living cells has proven to be laborious until the recent development of CRISPR-Cas9-ba

297 but still can be prohibitively expensive and laborious when community samples of thousands of specime

298 vs intercellular CO2 concentration, Ci ) is laborious, which limits availability of Vcmax data.

299 ructures are technologically challenging and laborious, which makes the development of computational

300 er's curse biases, which are reduced only by laborious winner's curse adjustments (WCAs).