ライフサイエンスコーパス: lack of

1 sortment process has been constrained by the lack of a coherent, model-based inference framework.

2 s remains a significant challenge due to the lack of a comprehensive computational tool that can faci

3 lineate, owing to its lineage complexity and lack of a concise genetic definition.

4 cation of this technique to zebrafish is the lack of a cost-effective method by which to identify mut

5 ts actual range is not well known due to the lack of a formal description until recent times (2006) a

6 grades of arrested retinal development with lack of a foveal pit and no cone photoreceptor outer seg

7 with half EREs could not compensate for the lack of a full ERE site within the cluster.

8 y has not been reported, likely owing to the lack of a mechanism to retain the injected substrate in

9 The lack of a paternal ancestry effect suggests underlying m

10 rains associated with Washington state, with lack of a predominant lineage and limited transmission a

11 resistant pathogens can be attributed to the lack of a rapid pathogen identification (ID) or antimicr

12 t favor efficient excision is limited by the lack of a rapid, accurate measurement of DNA excision ou

13 Following the injection, despite the lack of a redox counter-reaction or conventional electro

14 hy drug regimens, antibiotic resistance, and lack of a robustly efficacious vaccine.

15 F response between HBV genotypes B and C and lack of a single pattern of mutations among intra-host v

16 ce, and aid to the growing evidence that the lack of a specific cortical architecture does not hinder

17 ese genes has not been undertaken due to the lack of a stable transformation system.

18 Because of the lack of a standard definition for HFrecEF, and the pauci

19 However, the lack of a unified framework so far prevents a systematic

20 based strategies due to low activity and the lack of a well-validated pooled screening toolkit.

21 A lack of AAK6 reduces cell production in the aak6 root ap

22 associated with mortality and might reflect lack of access to post-discharge care and prescribing of

23 Lack of access to testing and concern regarding suboptim

24 Delayed or lack of action on implementation would push back the tim

25 nce similarity, low agonist selectivity, and lack of activation and G protein-coupling knowledge have

26 economy but is currently constrained by the lack of active and robust electrocatalysts from earth-ab

27 in glioblastoma therapy, owing in part to a lack of adequate preclinical in vivo models to study thi

28 Lack of adherence (nonadherence) or undertreatment (nonp

29 tention due to its potential specificity and lack of adverse side effects when compared to more tradi

30 Ultimately, the lack of AMPKbeta1 impairs, whereas deficiency of AMPKbet

31 olecular details remain unclear owing to the lack of an analytical method for global detection of pro

32 rch has been greatly hindered because of the lack of an animal model.

33 lly on this class of proteins because of the lack of an appropriate benchmark set.

34 However, to date, there is still the lack of an easy-to-manipulate system that enables the hi

35 The lack of an effect of ligands, the formation of carbon-ce

36 ized deep networks predict well, despite the lack of an explicit complexity control during training,

37 ic understanding of NCs has been hampered by lack of an in vitro assay that can track NC or NCLP asse

38 Unfortunately, the lack of analytic techniques has hindered researchers' ab

39 Until now, there has been a lack of analytical methods that can reliably verify the

40 the cause and consequences of vaping is the lack of animal models of nicotine vapor self-administrat

41 and underrepresented in research due to the lack of animal models.

42 was admitted to our hospital for high fever, lack of appetite related to nausea and vomiting, headach

43 the rarity of the disorder, with a resultant lack of appreciation of the diagnosis as a potential cau

44 A lack of approaches for antigen discovery has limited the

45 However, the lack of appropriate probes to bridge both microscopic re

46 of noncompositionally robust measures, and a lack of attention to social factors as confounders or ef

47 Due to a lack of authentic standards, however, commercial terpeno

48 n patients older than 3.8 years included the lack of availability of outpatient ultra-widefield FA (U

49 ropical deforestation affects climate is the lack of baseline conditions (i.e., prior to human distur

50 Therefore, the lack of BBSome function negatively impacts retinal synap

51 Lack of Bim1-binding by Cik1-Kar3 delays cells in mitosi

52 Lack of blood perfusion can cause irreversible cell dama

53 ropathogenesis remain elusive, mainly due to lack of brain-representative experimental systems to stu

54 laceae, Ruminococcaceae), but no significant lack of butyrogenic bacteria.

55 There is lack of Cameroonian adult norms for assessing SIP or mot

56 Conversely, lack of CD137L on T cells enhanced their diabetogenic ac

57 However, lack of cell type-specific tools have limited our abilit

58 ensors has, however, been limited due to the lack of cell-specific targeting methods in brain tissue

59 storage and microglial activation despite a lack of cerebrocortical atrophy in the oldest animals st

60 The very low energy combined with lack of charge gives the technique great potential for s

61 matched the warming pattern in Europe, but a lack of chilling and adaptation in farming may have reve

62 ase osteoarthritis (OA) is unclear, and this lack of clarity is detrimental to efforts to identify th

63 There remains a lack of clarity regarding the influence of sequencing of

64 wn to be implicated in MNDs, there remains a lack of clarity regarding the key functional pathways in

65 y studies were limited by their sample size, lack of clearly documented clinical staging, and lack of

66 ethods, inconsistent assessment metrics, and lack of clinical validation.

67 The phylogenetic analysis demonstrated the lack of clonal evolution for African strains which concl

68 A lack of common definitions and applications of REA acros

69 al-legal nature, as well as arising from the lack of confidence in the results of transplants from uD

70 acing cancer immunotherapy, which range from lack of confidence in translating pre-clinical findings

71 A lack of consensus on the management of bleeding complica

72 However, there is a lack of consensus regarding the presence, as well as the

73 areas are most commonly used, but there is a lack of consistency regarding the position of the measur

74 failure to state conflicts of interest, and lack of consultation with families of affected children.

75 g cells, but has proven difficult due to the lack of control over defined topological transformation

76 atalytic conditions demonstrate a surprising lack of correlation evident between V(on) and equivalent

77 A lack of cost-effective, reproducible models for the stud

78 Despite the lack of crosslinking observed, rheological and textural

79 ility of the crypt progenitor cells in vivo, lack of crypt base columnar stem cell markers, and a fai

80 o the asymptomatic nature of the disease and lack of curative treatment modalities, the 5-y survival

81 c and that environmental variability and the lack of data are a major source of uncertainty related t

82 Study limitations include lack of data on access to antiretroviral therapy (ART) c

83 A limitation of the study is lack of data on population prevalence of eye disease.

84 There is a lack of data on the use of direct-acting antivirals (DAA

85 few plant foods as healthy and less-healthy, lack of data on vegetable oil intake, and possibility of

86 biotic factors and biotic interactions, as a lack of data to evaluate the hypothesis, or be an artifa

87 in inferring gene regulatory networks is the lack of data.

88 ebaine could not be finally evaluated due to lack of data.

89 individuals and HD patients, supporting the lack of deficit in mitochondrial protein import.

90 for these procedures, has been limited by a lack of definitional clarity and their overly broad scop

91 istency and ambiguity in instructions show a lack of definitive knowledge on best spray use technique

92 ence to date is limited by self-report and a lack of detail regarding clinical revenue and gender dif

93 s include underrepresentation of women and a lack of detailed information on social determinants of h

94 In contrast, there is still a lack of diagnostic biomarkers of functional dystonia and

95 ren in these settings is difficult given the lack of diagnostic testing.

96 Considering lack of difference in BTMs between PIM/PIMP and cluster

97 these cells for almost two decades despite a lack of direct evidence.

98 onses in the early visual cortex despite the lack of direct receptive field activation.

99 of health in the African diaspora drive the lack of disease testing, increased prevalence of comorbi

100 e and the challenges that arise from the (1) lack of diversity in current reference populations and a

101 Lack of DOCK8 in Tregs resulted in their acquisition of

102 improve long-term cardiac function despite a lack of durable engraftment.

103 Lack of dynamic plasticity is a significant limitation f

104 as been often overlooked, largely due to the lack of easily accessible tool for reliable and natural

105 One possible explanation of this lack of effect is that well-practiced decisions are codi

106 egative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this dis

107 However, due to the lack of effective tools for rapid and noninvasive analys

108 rug categories in the past 10 years owing to lack of efficacy or tolerability, or both.

109 t have reached clinical trials failed due to lack of efficacy.

110 ed diagnosis and treatment of AKI due to the lack of efficient early diagnosis is an important cause

111 knowledge on the available diversity due to lack of efficient germplasm characterization and structu

112 oms is an extraordinary challenge due to the lack of electronic or steric bias between the two positi

113 The lack of empirical evidence for swift forest relocation a

114 but we anticipate that mothers exhibiting a lack of energy compensation are less likely to rear offs

115 perhaps sparingly, primarily because of the lack of enough training data and computational power.

116 Lack of ERalpha in GHRH neurons disrupts growth in both

117 However, minute size and lack of essential biomolecules (e.g. omega-3 polyunsatur

118 high prevalence, long incubation period and lack of established treatments or vaccines.

119 h educational attainment, survival bias, and lack of ethnic and socioeconomic diversity in this cohor

120 depressant prescriptions persisted despite a lack of evidence for their efficacy in bipolar disorder

121 severe obesity is increasing and there is a lack of evidence how these patients should be treated.

122 Unhealthy diet, lack of exercise, psychosocial stress, and insufficient

123 ing of cis-clustering has been hindered by a lack of experimental approaches capable of detecting and

124 dent adaptive evolution steps to address the lack of experimental methods to systematically identify

125 t such calibrations are precluded because of lack of experimental relative permeability data.

126 elf-assembly remain largely obscure due to a lack of experimental tools for probing these pathways at

127 Unfortunately lack of expertise can lead to improper diagnosis of woun

128 nts containing Y187 were sterile, indicating lack of fertility restoration.

129 However, the lack of firm age estimates for older Pleistocene termina

130 The first clinical report showed that a lack of FKBP22 protein due to mutations causing nonsense

131 models have poor fits to empirical data and lack of flexibility in capturing variation in growth rat

132 Lack of focused conservation and connectivity among bear

133 these large datasets are hindered due to the lack of formalization methods and tools able to unambigu

134 our previous model of SZ and can explain the lack of full efficacy of conventional antipsychotic medi

135 This lack of full-length genomes hampers our ability to under

136 tructural organization of neural cells and a lack of functional glia and vasculature.

137 mited clinical efficacy, possibly due to the lack of functional relevance of biomarker genes to cance

138 generating antibody-based inhibitors is the lack of fundamental information relating sequences of an

139 However, the lack of fundamental understanding on charge transport (C

140 At 1 week post-MI, lack of Gal-3 markedly attenuated F4/80+ macrophage infi

141 pleiotropic effects of genetic variants, and lack of generalizability of individual-level findings to

142 national attention for conservation, but the lack of genomic resources for Dalbergia hinders evolutio

143 tion-induced cell death is driven not by the lack of glucose, but rather by l-cystine import.

144 erogeneous or undetected causal antigens and lack of gold-standard biomarkers.

145 Background There is lack of guidance on specific CT protocols for imaging pa

146 cause of restricted insurance coverage and a lack of guidelines addressing the use of targeted panels

147 er, the risks of unwarranted antibiotics and lack of guidelines for procedures involving bone grafts

148 m oxide filters, selection of blue laser and lack of H(2)O(2) treatment.

149 sparse and empirical, presumably due to the lack of high-resolution instruments that can probe struc

150 gical implementation will be hampered by the lack of high-throughput techniques for exfoliating singl

151 cal properties, their low abundance, and the lack of highly specific antibodies, GPCRs are still chal

152 This lack of homogeneity could suggest that the deleterious e

153 ith increasing latency duration suggesting a lack of host or bacterial derived mutational stress.

154 Despite the lack of human-like TERRA promoters, we clearly detected

155 Lack of hypoalveolarization in Keap1(f/f) pups was accom

156 The reasons for this lack of improvement are currently unknown and require fu

157 However, due to lack of in vivo studies, the molecular mechanisms that g

158 These results suggest that the lack of increase in brain Asp and NAA is possibly becaus

159 as increased surface GLT-1 expression and a lack of increase in glutamate efflux during reinstatemen

160 Limitations of the study included lack of individual-level information on health status an

161 ertainties in C stock estimates as well as a lack of information about depth, bulk density and carbon

162 However, there has been a lack of information about Gdf15 activity and effects in

163 utations have been characterized, there is a lack of information about many recently identified clini

164 This lack of information may result from its complex and quan

165 nuclein (alpha-syn) fibrils, in part, due to lack of information of the structural properties of path

166 tendon therapeutics has been hindered by the lack of informative adult mammalian models of regenerati

167 This lack of institutional diversity, unless addressed, will

168 te-induced allergic airway inflammation, the lack of IRF4 expression in the DC compartment alleviates

169 t of their terminal differentiation owing to lack of KCTD1 leads to a severe salt-losing tubulopathy.

170 environment is well-established, there is a lack of knowledge about how species compromise camouflag

171 Tumor heterogeneity and lack of knowledge about resistant cell states remain a b

172 Currently, there is a lack of knowledge about the factors that influence disea

173 Cited barriers include lack of knowledge about the potential donor pool, lack o

174 However, the lack of knowledge about the transmission pathways limits

175 he development of curative strategies is the lack of knowledge regarding mechanisms that allow HIV-in

176 However, there is a lack of knowledge regarding their structural architectur

177 to reach the large intestine, explaining the lack of live pGP3-deficient Chlamydia sp. in rectal swab

178 Finding a lack of local connectivity, we used optogenetic circuit

179 marrow, resulting in hyporesponsiveness and lack of long-term persistence of Vi-specific IgG in seru

180 ibility remains unexplored on account of the lack of long-term prospective studies from infancy to th

181 heir ability to undergo apoptosis due to the lack of LTB(4) -mediated down-regulation of cAMP, subseq

182 he embryos potentially fail to thrive due to lack of luteal support.

183 system is thought to be limited owing to the lack of lymphatic drainage.

184 Together with lack of markers, the need for novel markers for the dete

185 nificant advances have been precluded by the lack of mechanistic explanations for the variety of its

186 despite ongoing questions of efficacy and a lack of mechanistic understanding of the underlying biol

187 In this study, the lack of methodology to access both syn and anti diastere

188 sment of their impact has been hampered by a lack of methodology to measure the amount of, and variab

189 rtant biological and chemical relevance, the lack of methods for their production has hampered access

190 s organization has remained elusive due to a lack of methods to directly probe nanoscopic membrane fe

191 The challenge lies in lack of methods to precisely modulate relative molecular

192 by trial and error efforts due to a critical lack of methods to probe their atomic-level microstructu

193 by the pathogen's slow doubling time and the lack of methods to quickly quantify the pathogen's respo

194 on, are very difficult to realize due to the lack of mirrors.

195 These failures were largely due to a lack of MMP-selective agents; accordingly, it has become

196 for industrial-scale applications, including lack of mono-selectivity, use of expensive oxidants and

197 IT logistical reasons and lack of motivation are barriers to uptake and compliance

198 ormation technology (IT) logistical reasons, lack of motivation, or competing life demands.

199 Due to lack of moving parts, the novel multi-analyte format is

200 endent prodrug, raising the possibility that lack of neuronal NQO1 activity has contributed to the li

201 rease of antimicrobial resistance (AMR), and lack of new classes of licensed antimicrobials, have mad

202 With a lack of noninvasive biomarkers to identify the presence

203 CR-based RNA-Seq library preparation and the lack of normal RNA-Seq data, presenting analytical chall

204 ogenic defects observed in Gli3 mutants from lack of olfactory ensheathing cells in the nasal mucosa,

205 Lack of OTR expression correlates with reduced dendritic

206 This lack of overall increase or decline was consistent acros

207 Given the lack of overarching validated framework and the generall

208 Lack of overlap likely stems from biological rather than

209 Lack of P2X7 promoted a transcriptional signature that c

210 Lack of pain identifies patients at low risk of metastas

211 d long-term oral tolerance, characterized by lack of parvalbumin-specific antibody and cellular respo

212 A lack of photoreduced Fe(2+) was measured in sediments wi

213 r immunobiology, but they are limited by the lack of physiological complexity.

214 of Tmem189-deficient mice may be caused by a lack of plasmalogens.

215 This lack of positive results in turn prompted questions on w

216 source, relating to its availability and the lack of possibility for standardization and to variation

217 rement on only the youngest children and the lack of power to detect small effect sizes with this rar

218 s in outcome measures and their definitions, lack of pre-specified protocols and/or trial registratio

219 F changes are sensed and signaled due to the lack of precise spatiotemporal control in vivo.

220 Lack of precision in both neuroanatomical and clinical b

221 s might be of overall higher quality but the lack of predation pressure and resource restrictions mas

222 Taken together with the lack of progression-free survival benefit, these finding

223 drugs to the infection site, as well as the lack of prolonged release.

224 Interestingly, we found that despite the lack of protein, CLASP transcript levels were higher in

225 oncept remains controversial due to presumed lack of public support.

226 crystal formation remains elusive due to the lack of quantitative experimental evidence.

227 nd fate of T cells in tumour immunity is the lack of quantitative information on the distribution of

228 However, there is lack of quantitative understanding of the interrelations

229 nts being evaluated for tuberculosis (TB), a lack of rapid diagnostic tests which can fully describe

230 hanical metamaterials remain hindered by the lack of rapid-prototyping ferroelectric metamaterial str

231 rotein structure alignment/comparison due to lack of real applications associated with GPSC.

232 urs, have been largely unexplored due to the lack of real-space imaging at single particle resolution

233 Lack of regular exercise was the most powerful factor to

234 However, the lack of reliable data on antimicrobial pharmacokinetics

235 these differences are unable to explain the lack of replication in Markel, 2020.

236 Here we examined the consequences due to the lack of representation by genotyping in a large number o

237 ticity, and memory in adulthood, despite the lack of requirement for neuronal survival.

238 A lack of research into the experiences of midwives meant

239 Nevertheless, the daily workload and the lack of resources sometimes limit the advance of radiolo

240 Es for innate immune studies is the relative lack of responsiveness to factors that stimulate epithel

241 for participants with a missing viral load, lack of retention in care in the on-site ART programme)

242 acial aluminosilicate mineral weathering and lack of retention of these species in sediments.

243 of knowledge about the potential donor pool, lack of robust outcomes data, lack of standard donor eli

244 182 Ma) are well understood but a lack of robust palaeotemperature data severely limits re

245 iction of outcome after LT is limited by the lack of robust predictors of graft failure.

246 However, the lack of robustness assessment poses problems for their a

247 ations suffer from severe angle sensitivity, lack of saturated color, and absence of black/gray state

248 a full-pulse analysis and may suffer from a lack of sensitivity and poor reaction time.

249 lantation has, however, been hampered by the lack of sensitivity of conventional instruments and assa

250 ic arms suffer from poor controllability and lack of sensory feedback.

251 architecture and phosphate binding motif, a lack of sequence identity and some fundamental structura

252 annotated sgl, mainly due to the small size, lack of sequence similarity, and embedded nature of thes

253 Moreover, a lack of serine results in the initiation of biofilm form

254 Penaeus stylirostris densovirus, despite the lack of significant capsid viral protein (VP) sequence s

255 The toxicity of baboon oligomers and lack of significantly detectable toxicity with exogenous

256 erapy technologies is limited in part by the lack of small genetic switches with wide dynamic ranges

257 Lack of SMGs and mucus strands disrupted mucociliary tra

258 We also determined that lack of social activities and physical exercise can enab

259 often remains incompletely analyzed due to a lack of sophisticated bioinformatic tools and field-spec

260 f N-glycans in rodent brains, but there is a lack of spatial resolution as either the tissue samples

261 omic datasets remains a challenge due to the lack of specific tools for doing so.

262 er, the study of RaF has been impeded by the lack of stable isotopes of radium.

263 al donor pool, lack of robust outcomes data, lack of standard donor eligibility criteria and preserva

264 remains highly controversial, likely due to lack of standardization of participants' energy balance.

265 However, the lack of standardized definitions and validated reference

266 urrent pregnancy loss has been hampered by a lack of standardized definitions, the uncertainties surr

267 es the origins of stereoselectivities or the lack of stereoselectivity, and evaluates why selectivity

268 on, elevated glucose, and an almost complete lack of stored triglycerides.

269 om adolescence to middle adulthood, and by a lack of substantial decline from middle to old adulthood

270 potential for aerosol spread and the current lack of sufficient countermeasures.

271 In particular, the lack of sufficient steric and electronic differences bet

272 However, progress is hindered by the lack of suitable analytical methods for rapid, routine,

273 ng is still challenging primarily due to the lack of suitable bioinks with high printability, biocomp

274 decay (NMD) degrades EJC-bound mRNA, but the lack of suitable methodology has prevented the identific

275 However, lack of suitable methodology, absence of consensus sequo

276 induced stress or cyclic strain demonstrates lack of support from the matrix in MFS CMs.

277 oV-2 infection and ameliorate disease is the lack of susceptible small animals in large numbers.

278 0.88; GLMM aRR 0.85, 95% CI 0.83 - 0.87 and lack of sustained VS (N=2,499; LR aRR 0.75, 95% CI 0.68

279 ized by developmental delay, seizures, and a lack of sweat and tears.

280 comings in a number of guidelines, including lack of systematic processes in formulating guidelines,

281 mmune responses is currently hampered by the lack of systems enabling quantitative and dynamic phenot

282 typically an incurable malignancy due to the lack of targetable surface targets for development of ef

283 This is partly due to a lack of targetable, organ-specific markers for in vivo s

284 in nanopores(1-5) have been hampered by the lack of techniques with sufficient sensitivity to discer

285 odegenerative diseases, and we show that the lack of the Caenorhabditis elegans Msp1 homologue trigge

286 ISPR-Cas-based nucleic acid biosensing has a lack of the quantitative detection ability and typically

287 Given the current lack of third-line treatment options, this approach warr

288 The lack of tissue substitutes with mechanical and biologica

289 The lack of tools to reliably detect RanBP9 in vivo has sign

290 Hepatology providers report lack of training to deliver PC along with no clear progn

291 The lack of transferability is often met with a largely empi

292 mal models, strategy for drug selection, and lack of translational endpoints between animals and huma

293 Potential lack of tropospheric relevance associated with these che

294 oach to cancer therapy but is limited by the lack of tumor-homing capability of the current antiangio

295 We previously showed that the lack of Ube3a-mediated ubiquitination of the Ca(2+)-acti

296 usion in atmospheric models is hindered by a lack of understanding of the first steps of the photoche

297 Chagas drug discovery has been hampered by a lack of validated assays to establish treatment efficacy

298 Lack of vector-neutralizing Ab responses should facilita

299 of clearly documented clinical staging, and lack of well-defined gold standards.

300 Finally, the lack of well-validated methodology for choosing the rank