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1 del of aqueous-deficient dry eye produced by lacrimal ablation, topical administration of 0.1 nmol CF
2 basal tear protein secretion in cultured rat lacrimal acinar cells and proliferation of subconfluent
6 (IP(3)Rs), and ryanodine receptors (RyRs) in lacrimal acinar cells, however, little is known regardin
8 Sox9 is required for the development of the lacrimal and harderian glands and contributes to the for
10 Lubricin messenger RNA is also present in lacrimal and meibomian glands, as well as in a number of
11 lopment of new strategies to maintain normal lacrimal and salivary gland function in patients with SS
14 me is a chronic autoimmune disease affecting lacrimal and salivary glands that often is accompanied b
18 l injuries (eyelid lacerations and damage to lacrimal apparatus) were recorded in 1265 of 5719 patien
20 patients (group 2) who had an absence of the lacrimal artery or deviated from the treatment protocol
22 that optimal surgical management of chronic lacrimal canaliculitis allows for both accurate microbio
23 st documented case of A. aphrophilus chronic lacrimal canaliculitis illustrates that optimal surgical
24 ral chronic epiphora associated with chronic lacrimal canaliculitis resistant to prolonged topical an
25 The "wedge sign" frequency is assessed in lacrimal carcinoma, lacrimal lymphoma, or dacryoadenitis
26 point of a vertical line passing through the lacrimal caruncle and an oblique line joining the latera
27 point of a vertical line passing through the lacrimal caruncle and an oblique line joining the latera
30 The lateral canthus, subnasal point, and lacrimal caruncle were used as anatomic reference points
34 ting a hereditary component in patients with lacrimal disorders is helpful in determining the underly
36 mpletion of chemotherapy, patients underwent lacrimal drainage evaluation by computed tomographic dac
37 Tear film impairment (aqueous and lipid) and lacrimal drainage obstruction should be considered in su
40 P2 was washed off after 2 min, (representing lacrimal drainage) 0.071% penetrated porcine cornea by 6
42 er blood flow changes around the ipsilateral lacrimal duct, superior salivatory nucleus stimulation e
43 unction (11% prevalence) was associated with lacrimal dysfunction (P = 0.010) and xerostomia with xer
44 ent (erythema and sclerosis, skin symptoms), lacrimal dysfunction (Schirmer's tear test, xerophthalmi
46 eaction when cocultured with purified rabbit lacrimal epithelial cells, induce a Sjogren's-like autoi
48 ear volume and tear composition (osmolarity, lacrimal factors, inflammatory mediators, growth and dif
49 al role of the proteins in the regulation of lacrimal fluid secretion under physiological and disease
50 n produce a significant deterioration of the lacrimal function unit in female SS dry eye patients.
53 athology of DED involves inflammation of the lacrimal functional unit (LFU), comprising the cornea, c
63 us, and evaluate its effects on the inflamed lacrimal gland (LG) of non-obese diabetic mouse (NOD), a
65 ia receptor-mediated transcytosis across the lacrimal gland (LG), which produces the bulk of human te
67 the eyelids (n = 53 [82%]), followed by the lacrimal gland (n = 5), conjunctiva (n = 4), and eyebrow
68 ed a rare case of pleomorphic adenoma of the lacrimal gland (PALG) causing hyperopic shift and CFs wi
79 (typically the lateral) and, less often, the lacrimal gland and is often mild when it arises during o
80 but not Pax6(PE/PE) mice, developed stunted lacrimal gland and lens hypoplasia which was significant
82 as to investigate an enlarged dacryoadenotic lacrimal gland and normal lacrimal glands for the presen
86 hanism, and gene fusion detection methods in lacrimal gland and primary orbital and ocular adnexal so
88 vated by adenosine triphosphate (ATP) in rat lacrimal gland and to determine their role in protein se
89 es were reviewed and microscopic sections of lacrimal gland biopsy samples were critically re-evaluat
91 ) and P2X(6)receptors were identified in the lacrimal gland by RT-PCR, Western blot, and immunofluore
92 ession in sarcoidosis involving the orbit or lacrimal gland can be distinguished from gene expression
95 aging for 116 patients was reviewed: 39 with lacrimal gland carcinoma, 37 with lymphoma, and 40 with
97 mposed of rabbit conjunctival epithelium and lacrimal gland cell spheroids, and recapitulates the aqu
99 ioma (n = 4; 10%), melanocytoma (n = 3; 8%), lacrimal gland choristoma (n = 2; 5%), gliosis (n = 1; 3
100 genetic rescue experiments in which the Ugdh lacrimal gland defect is ameliorated by constitutive Ras
101 tive FGF receptor only partially rescued the lacrimal gland defects in Sox9 heterozygotes, suggesting
103 Therefore, Fgf10-Fgfr2b signaling during lacrimal gland development is sensitive to the content o
105 ogether, our data reveal crucial features of lacrimal gland development that have broad implications
106 st;Hs6st double mutants completely abolished lacrimal gland development, suggesting that both 2-O and
111 infective debris (1 case) from the affected lacrimal gland ductule--typically the most inferolateral
113 disease, (2) salivary gland dysfunction and lacrimal gland dysfunction, and (3) limited mouth-openin
115 the co-receptors for Fgf10 signaling in the lacrimal gland epithelium, but their function in the Fgf
121 fibroblasts were elevated in cGVHD-affected lacrimal gland fibroblasts and (2) that they could be re
122 absence of recent upper respiratory illness, lacrimal gland focus, multiple orbital abscesses, and la
127 molecular signalling processes that control lacrimal gland function will give insight into correctiv
129 The Hs6st mutants exhibited significant lacrimal gland hypoplasia and a strong genetic interacti
131 te complex on the cell surface and prevented lacrimal gland induction by Fgf10 in explant cultures.
132 ts demonstrate that mesenchymal GAG controls lacrimal gland induction by restricting the diffusion of
133 se occurs in the setting of conjunctival and lacrimal gland inflammation, potentially mediated by the
134 R(-/-)) had the same submandibular gland and lacrimal gland injury as did the IL14alphaTG mice, but t
135 by Jin et al that studied the regulation of lacrimal gland innervation by sympathetic and parasympat
136 It was recently reported that repair of the lacrimal gland involved the mobilization of mesenchymal
138 inical and imaging features of patients with lacrimal gland involvement secondary to GPA and to compa
139 nd to have orbital inflammatory disease with lacrimal gland involvement, of whom 7 had a final diagno
141 Ongoing studies demonstrate that the murine lacrimal gland is capable of repair after experimentally
142 , and secretion from the acinar cells of the lacrimal gland is regulated by both cholinergic and adre
146 confirms that a subset of isolated epibulbar lacrimal gland lesions differs morphologically and immun
147 to overt, suggesting that isolated epibulbar lacrimal gland lesions may have originated from precurso
148 d complex choristoma, all isolated epibulbar lacrimal gland lesions were composed predominantly of va
154 egenerative potential in a rabbit model with lacrimal gland main excretory duct ligation-induced inju
155 erwent debulking surgery of the inflammatory lacrimal gland mass for diagnostic and therapeutic reaso
157 ot attenuate lymphocytic infiltration of the lacrimal gland or eye, it significantly reduced ocular s
158 A total of 36 tumors from 32 patients with lacrimal gland PA or Ca-ex-PA were included in the study
160 oma and generally indicates life-threatening lacrimal gland pathology that requires urgent biopsy.
170 The results provide further insights into lacrimal gland stem/progenitor cell physiology and their
172 iple pustules/abscesses in the region of the lacrimal gland that were expressing purulent fluid into
173 ically and immunohistochemically from normal lacrimal gland tissue and the lacrimal gland in a comple
177 fforts, the molecular and cellular events in lacrimal gland tissues initiating inflammatory responses
178 und that EMT is induced during repair of the lacrimal gland to generate MSCs to initiate repair, and
186 idosis (7 in adipose tissue; 5 affecting the lacrimal gland) as well as comparable tissue from 6 heal
190 Human fibroblasts were isolated from the lacrimal gland, cornea, and Tenon's capsule and treated
191 eyelid, conjunctiva, choroid, ciliary body, lacrimal gland, or orbit (OA-uveal lymphoma) were includ
192 Secretory function also increased in the lacrimal gland, suggesting this local therapy could trea
193 rkers between the developing mouse and human lacrimal gland, supporting the use of mice to understand
194 voked macrophage infiltration to the eye and lacrimal gland, where they played a functional role in d
210 nificant decreases were also observed in the lacrimal glands (49% +/- 13%, P < 0.001), liver (15% +/-
211 yndrome (SS) patients tears and in tears and lacrimal glands (LG) of male non-obese diabetic (NOD) mi
214 lands of Wolfring is similar to that of main lacrimal glands and are consistent with secretion electr
217 oimmune disease starting in the salivary and lacrimal glands and continuing to involve the lungs and
218 sialin, a known nitrate transporter, in the lacrimal glands and other eye components, and also xanth
219 sing the frequency of CD45(+)CD4(+) cells in lacrimal glands and significantly increasing conjunctiva
222 ounds localize to the parotid, salivary, and lacrimal glands as well as to the kidney, leading to dos
223 expression profiles of C57BL/6.NOD-Aec1Aec2 lacrimal glands before, or concomitant with, the first a
224 st that nitrate ions are concentrated in the lacrimal glands by sialin and can be secreted into eye c
230 multifactorial chronic disorder in which the lacrimal glands fail to produce enough tears to maintain
231 ged dacryoadenotic lacrimal gland and normal lacrimal glands for the presence of goblet cells (mucocy
235 cant difference (p = 0.03) in the ADC of the lacrimal glands in patients with active (n = 24) and ina
238 hat occur in myoepithelial cells (MECs) from lacrimal glands of a mouse model of Sjogren syndrome.
239 gene expression profiles were generated for lacrimal glands of C57BL/6.NOD-Aec1Aec2 mice 4 to 20 wee
243 ioration of the autonomic innervation of the lacrimal glands rather than an impaired corneal innervat
248 cterize the role of Orai1 in the function of lacrimal glands using a mouse model in which the gene fo
249 : 1) initial injury to the submandibular and lacrimal glands via an environmental insult and LTalpha;
250 nt diffusion coefficient (ADC) values of the lacrimal glands were calculated and correlated with the
253 tissue PMN population in the corneal limbus, lacrimal glands, and cervical lymph nodes of healthy mal
257 usly, in single lacrimal cells isolated from lacrimal glands, we demonstrated that muscarinic recepto
267 conjunctival epithelium, eyelids and ocular [lacrimal, harderian (HG), and meibomian (MG)] glands and
269 Exclusion criteria included evidence of lacrimal hypersecretion, eyelid malposition, and punctal
271 of orbital GPA, especially in patients with lacrimal involvement as the initial presentation, can be
273 y affects exocrine glands--mainly labial and lacrimal--leading to complaints of dry mouth and eyes.
275 pendages: skin, teeth, and nails--as well as lacrimal, mammary, salivary, sebaceous and sweat glands.
277 cluded that the modified preserved nasal and lacrimal mucosal flap technique in EES-DCR for treating
279 e we describe a modified preserved nasal and lacrimal mucosal flap technique in endonasal endoscopic
280 e analyzed by placing regions of interest on lacrimal, parotid, and submandibular glands; left ventri
281 (OCT) and to identify characteristics of the lacrimal punctum in patients who benefit from punctoplas
283 mine the application of imaging the stenotic lacrimal punctum with infrared photographs and optical c
284 tion of exocrine glands, mainly salivary and lacrimal, resulting in oral and ocular dryness, although
285 n to receive either percutaneous drainage of lacrimal sac abscess followed by EN-DCR after the acute
288 le participants had acute dacryocystitis and lacrimal sac abscess presenting within 2 weeks of onset,
289 Primary EN-DCR in acute dacryocystitis with lacrimal sac abscess results in faster resolution compar
290 obstruction to include DCR revisions, acute lacrimal sac abscesses, nasolacrimal duct obstructions i
295 al applications, and an increasing number of lacrimal surgeons have focused on laser-assisted approac
299 reports of inherited disorders affecting the lacrimal system that have not been elucidated molecularl