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1 mediated assembly to form a depot inside the lacrimal gland.
2 e formation of secretory acinar lobes in the lacrimal gland.
3 on were determined at the ocular surface and lacrimal gland.
4 nic inflammation in the underlying stroma or lacrimal gland.
5 ptors P2X(1-4) and P2X(6) are present in the lacrimal gland.
6 olycystin-2L2) were expressed in adult mouse lacrimal gland.
7 that P2X(7)receptors were functional in the lacrimal gland.
8 een oxidative stress and inflammation in the lacrimal gland.
9 ion of interleukin (IL)-1 into the exorbital lacrimal gland.
10 es (Hs2st, Hs6st1, and Hs6st2) in developing lacrimal gland.
11 esenchymal transition (EMT) in repair of the lacrimal gland.
12 thelium, but not in the CN epithelium or the lacrimal gland.
13 in AL2 mRNA was detected only in male rabbit lacrimal gland.
14 2, BL, CL, and CL2 were detected only in the lacrimal gland.
15 veral lipophilins were expressed only in the lacrimal gland.
16 f Tregs and CD4(+) IFN-gamma(+) cells in the lacrimal gland.
17 gher uptake in kidneys, urinary bladder, and lacrimal gland.
18 of unipotent KRT5(+) epithelial cells in the lacrimal gland.
19 uclear cell infiltration in the salivary and lacrimal glands.
20 mpare the findings with those in five normal lacrimal glands.
21 utoimmune disease affecting the salivary and lacrimal glands.
22 from IL-1-injected, but not saline-injected, lacrimal glands.
23 autoimmune diseases of ovary, prostate, and lacrimal glands.
24 surface epithelia and on fluid secretion by lacrimal glands.
25 so known as lipophilins, are found in rabbit lacrimal glands.
26 njunctiva, cornea, and tears produced by the lacrimal glands.
27 lymphocyte infiltrations in the extraorbital lacrimal glands.
28 e exocrine glands including the salivary and lacrimal glands.
29 ning cells in both dacryoadenotic and normal lacrimal glands.
30 4 h but did not reduce uptake in kidneys and lacrimal glands.
31 alpha1, collagen type IIIalpha1 and NF-kB in lacrimal glands.
32 ltration of inflammatory/immune cells in the lacrimal glands.
33 y excessive inflammation and fibrosis in the lacrimal glands.
34 immune disease mainly affecting salivary and lacrimal glands.
36 nificant decreases were also observed in the lacrimal glands (49% +/- 13%, P < 0.001), liver (15% +/-
52 (typically the lateral) and, less often, the lacrimal gland and is often mild when it arises during o
53 but not Pax6(PE/PE) mice, developed stunted lacrimal gland and lens hypoplasia which was significant
55 as to investigate an enlarged dacryoadenotic lacrimal gland and normal lacrimal glands for the presen
56 regulator (aire)-deficient mice, we assessed lacrimal gland and ocular surface immunopathology by qua
60 hanism, and gene fusion detection methods in lacrimal gland and primary orbital and ocular adnexal so
64 y localized gp340 to the acinar cells of the lacrimal gland and the deeper layers of the conjunctival
65 vated by adenosine triphosphate (ATP) in rat lacrimal gland and to determine their role in protein se
66 X(7) purinergic receptors are present in rat lacrimal gland and when stimulated increase [Ca(2+)](i),
68 lands of Wolfring is similar to that of main lacrimal glands and are consistent with secretion electr
71 oimmune disease starting in the salivary and lacrimal glands and continuing to involve the lungs and
72 sialin, a known nitrate transporter, in the lacrimal glands and other eye components, and also xanth
73 sing the frequency of CD45(+)CD4(+) cells in lacrimal glands and significantly increasing conjunctiva
74 ation of primarily CD4(+) T cells within the lacrimal glands and with increased expression of IL-4.
76 cells in the inflammatory infiltrates of the lacrimal gland, and the presence of anti-Sjogren's syndr
77 tissue PMN population in the corneal limbus, lacrimal glands, and cervical lymph nodes of healthy mal
80 ch as marked lymphocytic infiltration of the lacrimal glands, antinuclear antibodies in the serum, an
83 ounds localize to the parotid, salivary, and lacrimal glands as well as to the kidney, leading to dos
84 idosis (7 in adipose tissue; 5 affecting the lacrimal gland) as well as comparable tissue from 6 heal
85 inflammatory CD4(+) T cells detected in the lacrimal gland, as well as those in the periphery of old
86 to mononuclear infiltration of salivary and lacrimal glands, as well as to expansion of bronchial ly
87 increased apoptosis and deterioration in the lacrimal gland, associated dysfunction, and development
88 pproach, however, we have identified a novel lacrimal gland autoantigen, odorant binding protein 1a,
89 to investigate the pathogenic mechanisms in lacrimal gland autoimmunity and associated ocular surfac
90 expression profiles of C57BL/6.NOD-Aec1Aec2 lacrimal glands before, or concomitant with, the first a
91 es were reviewed and microscopic sections of lacrimal gland biopsy samples were critically re-evaluat
95 Consistent with this, Fgf10-induced ectopic lacrimal gland budding in explant cultures is dependent
96 , and epithelial deletion of Fgfr2 abolishes lacrimal gland budding, its specific modification of hep
97 on, we demonstrate that Shp2 is required for lacrimal gland budding, lens cell proliferation, surviva
101 ) and P2X(6)receptors were identified in the lacrimal gland by RT-PCR, Western blot, and immunofluore
102 st that nitrate ions are concentrated in the lacrimal glands by sialin and can be secreted into eye c
103 ession in sarcoidosis involving the orbit or lacrimal gland can be distinguished from gene expression
106 aging for 116 patients was reviewed: 39 with lacrimal gland carcinoma, 37 with lymphoma, and 40 with
109 mposed of rabbit conjunctival epithelium and lacrimal gland cell spheroids, and recapitulates the aqu
112 ioma (n = 4; 10%), melanocytoma (n = 3; 8%), lacrimal gland choristoma (n = 2; 5%), gliosis (n = 1; 3
113 eased infiltration of mononuclear cells into lacrimal glands compared with 4-1BB intact lpr mice.
117 Human fibroblasts were isolated from the lacrimal gland, cornea, and Tenon's capsule and treated
120 genetic rescue experiments in which the Ugdh lacrimal gland defect is ameliorated by constitutive Ras
121 tive FGF receptor only partially rescued the lacrimal gland defects in Sox9 heterozygotes, suggesting
123 Therefore, Fgf10-Fgfr2b signaling during lacrimal gland development is sensitive to the content o
126 ogether, our data reveal crucial features of lacrimal gland development that have broad implications
127 nly for modulating Ras signaling in lens and lacrimal gland development, but also for RTK signaling i
128 st;Hs6st double mutants completely abolished lacrimal gland development, suggesting that both 2-O and
132 hy in NOD/LtJ mice an in-depth evaluation of lacrimal gland disease in the NOD/LtJ mouse has remained
135 provides an excellent approach for studying lacrimal gland duct cells about which relatively little
137 infective debris (1 case) from the affected lacrimal gland ductule--typically the most inferolateral
139 disease manifested primarily by salivary and lacrimal gland dysfunction resulting in dry mouth/dry ey
140 disease, (2) salivary gland dysfunction and lacrimal gland dysfunction, and (3) limited mouth-openin
143 ecific requirement of Ndst1 and Ndst2 in the lacrimal gland epithelial, but not mesenchymal, cells, a
144 the co-receptors for Fgf10 signaling in the lacrimal gland epithelium, but their function in the Fgf
151 multifactorial chronic disorder in which the lacrimal glands fail to produce enough tears to maintain
153 fibroblasts were elevated in cGVHD-affected lacrimal gland fibroblasts and (2) that they could be re
154 absence of recent upper respiratory illness, lacrimal gland focus, multiple orbital abscesses, and la
156 ged dacryoadenotic lacrimal gland and normal lacrimal glands for the presence of goblet cells (mucocy
163 molecular signalling processes that control lacrimal gland function will give insight into correctiv
166 The Hs6st mutants exhibited significant lacrimal gland hypoplasia and a strong genetic interacti
169 cant difference (p = 0.03) in the ADC of the lacrimal glands in patients with active (n = 24) and ina
171 te complex on the cell surface and prevented lacrimal gland induction by Fgf10 in explant cultures.
172 ts demonstrate that mesenchymal GAG controls lacrimal gland induction by restricting the diffusion of
174 se occurs in the setting of conjunctival and lacrimal gland inflammation, potentially mediated by the
179 R(-/-)) had the same submandibular gland and lacrimal gland injury as did the IL14alphaTG mice, but t
181 by Jin et al that studied the regulation of lacrimal gland innervation by sympathetic and parasympat
182 It was recently reported that repair of the lacrimal gland involved the mobilization of mesenchymal
184 inical and imaging features of patients with lacrimal gland involvement secondary to GPA and to compa
185 nd to have orbital inflammatory disease with lacrimal gland involvement, of whom 7 had a final diagno
187 Ongoing studies demonstrate that the murine lacrimal gland is capable of repair after experimentally
188 Previously, it was reported that the murine lacrimal gland is capable of repair after experimentally
190 , and secretion from the acinar cells of the lacrimal gland is regulated by both cholinergic and adre
193 disease affecting primarily the salivary and lacrimal glands leading to xerostomia (dry mouth) and xe
196 confirms that a subset of isolated epibulbar lacrimal gland lesions differs morphologically and immun
197 to overt, suggesting that isolated epibulbar lacrimal gland lesions may have originated from precurso
198 Deletion of 4-1BB in lpr mice accelerates lacrimal gland lesions through increased CD4(+) T-cell i
199 d complex choristoma, all isolated epibulbar lacrimal gland lesions were composed predominantly of va
207 us, and evaluate its effects on the inflamed lacrimal gland (LG) of non-obese diabetic mouse (NOD), a
210 ia receptor-mediated transcytosis across the lacrimal gland (LG), which produces the bulk of human te
213 yndrome (SS) patients tears and in tears and lacrimal glands (LG) of male non-obese diabetic (NOD) mi
214 me-related immunopathological changes in the lacrimal glands (LGs) of CD25KO mice, we examined LGs of
218 xual dimorphic expression patterns of rabbit lacrimal gland lipophilins AL, AL2, BL, CL, and CL2 were
219 N) preferentially suppress AOD and Treg from lacrimal gland LN preferentially suppress dacryoadenitis
223 ents of alpha-fodrin were found in tears and lacrimal gland lysates, respectively, of lpr/4-1BB(-/-)
224 egenerative potential in a rabbit model with lacrimal gland main excretory duct ligation-induced inju
225 erwent debulking surgery of the inflammatory lacrimal gland mass for diagnostic and therapeutic reaso
227 t therapy, and bioartificial devices such as lacrimal gland microdevices and keratoprostheses, or tis
228 the eyelids (n = 53 [82%]), followed by the lacrimal gland (n = 5), conjunctiva (n = 4), and eyebrow
229 hat occur in myoepithelial cells (MECs) from lacrimal glands of a mouse model of Sjogren syndrome.
230 ha, 1 microg in 2 microL) into the exorbital lacrimal glands of anesthetized female BALB/c mice.
231 gene expression profiles were generated for lacrimal glands of C57BL/6.NOD-Aec1Aec2 mice 4 to 20 wee
234 amma than IL-13 mRNA relative transcripts in lacrimal glands of MRL/lpr/IL-4(tm) mice (mean differenc
236 ot attenuate lymphocytic infiltration of the lacrimal gland or eye, it significantly reduced ocular s
237 eyelid, conjunctiva, choroid, ciliary body, lacrimal gland, or orbit (OA-uveal lymphoma) were includ
238 A total of 36 tumors from 32 patients with lacrimal gland PA or Ca-ex-PA were included in the study
239 ed a rare case of pleomorphic adenoma of the lacrimal gland (PALG) causing hyperopic shift and CFs wi
241 oma and generally indicates life-threatening lacrimal gland pathology that requires urgent biopsy.
249 L-1beta activates the ERK pathway to inhibit lacrimal gland protein secretion and aqueous tear produc
253 ioration of the autonomic innervation of the lacrimal glands rather than an impaired corneal innervat
257 Lacritin protein is highly expressed in the lacrimal gland, secreted into tear fluid, and detected o
262 ants (e.g., urinary pheromones, extraorbital lacrimal gland secretions, major histocompatibility comp
263 ferential display analysis, and a new rabbit lacrimal gland secretoglobin, lipophilin AL2, was identi
265 ut ((-/-)) mice have impaired ocular surface-lacrimal gland signaling, rendering them susceptible to
267 The results provide further insights into lacrimal gland stem/progenitor cell physiology and their
269 Secretory function also increased in the lacrimal gland, suggesting this local therapy could trea
270 rkers between the developing mouse and human lacrimal gland, supporting the use of mice to understand
272 iple pustules/abscesses in the region of the lacrimal gland that were expressing purulent fluid into
273 ically and immunohistochemically from normal lacrimal gland tissue and the lacrimal gland in a comple
277 fforts, the molecular and cellular events in lacrimal gland tissues initiating inflammatory responses
278 und that EMT is induced during repair of the lacrimal gland to generate MSCs to initiate repair, and
282 cterize the role of Orai1 in the function of lacrimal glands using a mouse model in which the gene fo
283 : 1) initial injury to the submandibular and lacrimal glands via an environmental insult and LTalpha;
287 usly, in single lacrimal cells isolated from lacrimal glands, we demonstrated that muscarinic recepto
288 e were noted to have significantly increased lacrimal gland weight, with enlarged, carbohydrate-rich,
293 nt diffusion coefficient (ADC) values of the lacrimal glands were calculated and correlated with the
296 ted acinar epithelial monolayers from rabbit lacrimal glands were exposed to varying concentrations o
300 voked macrophage infiltration to the eye and lacrimal gland, where they played a functional role in d